moving touch therapy|
5812179|NCT00065182|Drug|Topotecan/Docetaxel combination|
5812180|NCT00065182|Drug|Docetaxel|
5812181|NCT00065169|Drug|Celecoxib|
5812182|NCT00065156|Drug|lenalidomide|10 mg orally once daily for 21 days out of a 28-day cycle (syncopated); subsequently amended (Amendment 1, dated 27 August 2003) to employ a continuous dosage regimen in which 10 mg was taken once daily for 28 day cycles (continuous). Subjects who initially began a syncopated regimen and who did not experience a dose-limiting adverse event were allowed to switch to the continuous regimen.
5812183|NCT00065143|Drug|clofarabine|
5812184|NCT00065143|Drug|Ara-C|
5812185|NCT00065130|Drug|human insulin|
5812186|NCT00065130|Drug|insulin NPH|
5812187|NCT00065130|Drug|insulin aspart|
5812188|NCT00065117|Drug|ZD6126|
5812189|NCT00065117|Drug|Placebo|
5812190|NCT00065117|Drug|5-fluorouracil|
5812191|NCT00065117|Drug|leucovorin|
5812192|NCT00065117|Drug|oxaliplatin|
5812193|NCT00065104|Drug|DHEA|
5812194|NCT00065078|Procedure|Home dispensing of contraception|
5812195|NCT00065065|Drug|Rosiglitazone|4mg orally twice daily for 12 weeks
5812196|NCT00065065|Drug|Placebo|pill that looks identical to rosiglitazone
5812197|NCT00065052|Behavioral|Behavior modification|
5812198|NCT00065039|Behavioral|Promotion of a healthy diet and physical activity|
5812199|NCT00065039|Behavioral|Avoidance of Alcohol, Drugs, and Tobacco|
5812200|NCT00065026|Behavioral|Physical activity opportunities for low-income women|
5812201|NCT00065013|Behavioral|strength training|
5812202|NCT00065000|Behavioral|Water, Cafeteria and Staff Health Promotion|
5812203|NCT00004204|Drug|temozolomide|
5812204|NCT00004006|Biological|filgrastim|
5812205|NCT00004006|Drug|carboplatin|
5812206|NCT00004006|Drug|cyclophosphamide|
5812207|NCT00004006|Drug|doxorubicin hydrochloride|
5812208|NCT00004006|Drug|etoposide|
5812209|NCT00004006|Drug|topotecan hydrochloride|
5812210|NCT00004006|Procedure|autologous bone marrow transplantation|
5812211|NCT00004006|Radiation|radiation therapy|
5812212|NCT00003895|Biological|HPV 16 E7:12-20|Given SC
5812213|NCT00003895|Biological|gp100:209-217(210M)|Given SC
5812214|NCT00003895|Other|laboratory biomarker analysis|Correlative studies
5812215|NCT00003795|Procedure|quality-of-life assessment|
5812216|NCT00003759|Biological|BCG vaccine|
5812217|NCT00003759|Drug|valrubicin|
5812218|NCT00003759|Procedure|conventional surgery|
5812219|NCT00064987|Procedure|Testicular biopsy|Outpatient surgical procedure.
5812220|NCT00064987|Drug|gonadotropin releasing hormone (GnRH)|Pulsatile GnRH (25 ng/kg per bolus every two hours via microinfusion pump titrated to reach normal serum testosterone levels)
5812221|NCT00064987|Drug|follicle stimulating hormone (FSH)|75 IU subcutaneous injection daily for four months.
5812222|NCT00064974|Drug|CC-5013|CC-5013 10 mg (two 5 mg capsules) daily on days 1-28 every 28 days (28 day cycles)
5812223|NCT00064961|Behavioral|Individualized dietary-control and exercise program|
5812224|NCT00064961|Behavioral|Weight-management and smoking cessation maintenance|
5812225|NCT00064961|Behavioral|Smoking Cessation program|
5812226|NCT00064935|Procedure|Endometrial biopsy|
5812227|NCT00064922|Behavioral|Behavior Therapy|
5812228|NCT00064857|Drug|Pycnogenol|
5812229|NCT00064896|Procedure|MRI|
5812230|NCT00064844|Behavioral|Cognitive Behavior Therapy for alcohol and smoking cessation|Individual 60-minute treatment sessions were scheduled weekly for the first 3 months, then monthly for the next 3 months for a total of 16 sessions. Alcohol treatment was based on the cognitive behavioral therapy manual developed for Project MATCH, with approximately 40-45 minutes of each session devoted to alcohol treatment. Components of this intervention included identifying alcohol antecedents, coping with alcohol urges, managing thoughts about alcohol, problem solving, drink refusal skills, planning for emergencies, communication and assertiveness training and enhancing social support networks for alcohol abstinence. The smoking cessation intervention was delivered in the same sessions as the alcohol treatment, with approximately 15-20 minutes of each session devoted to smoking cessation. Treatment employed behavioral elements that have been supported empirically according to the USDHHS smoking cessation practice guideline.
5812231|NCT00064831|Drug|Black Cohosh Extract (BCE)|
5812232|NCT00064805|Behavioral|Cognitive Therapy to Improve Reading|
5812233|NCT00064779|Drug|IL13-PE38QQR|
5812234|NCT00064779|Procedure|targeted fusion protein therapy|
5812237|NCT00064753|Drug|High Dose Multivitamin|Vitamin B6 (Pyridoxine HCl): 50 mg Folic acid: 5.0 mg Vitamin B12: 1.0 mg Vitamin B1 (Thiamine HNO3): 1.5 mg Vitamin B2 (Riboflavin): 1.5 mg Vitamin C (Ascorbic Acid): 60 mg d-Biotin: 300 mcg Niacinamide: 20 mg Pantothenic Acid Calcium Pantothenate): 10 mg
5812238|NCT00064753|Device|Low Dose Multivitamin|Vitamin B6 (Pyridoxine HCl): 1.4 mg Folic acid: 0.0 mg Vitamin B12: 2.0 mcg Vitamin B1 (Thiamine HNO3): 1.5 mg Vitamin B2 (Riboflavin): 1.5 mg Vitamin C (Ascorbic Acid): 60 mg d-Biotin: 300 mcg Niacinamide: 20 mg Pantothenic Acid Calcium Pantothenate): 10 mg
5812239|NCT00003712|Drug|temsirolimus|"•Part I: Patients receive CCI-779 IV over 30 minutes on days 1-5, followed by a 9 day rest period. Treatment courses repeat every 2 weeks in the absence of disease progression or unacceptable toxicity.~The maximum tolerated dose for part I is defined as the dose level at which 33% of patients experience dose limiting toxicity.~•Part II: Patients receive the same treatment schedule as part I. Three patients with CNS tumors are entered at the dose of CCI-779 determined to be the MTD in Part I. At least 3 patients are entered at each dose level in part II."
5812240|NCT00003707|Drug|gemcitabine hydrochloride|
5812241|NCT00003707|Drug|tipifarnib|
5812242|NCT00003645|Drug|Flutamide|10.8 mg intramuscularly once every 3 months for 12 months
5812243|NCT00003645|Drug|Leuprolide Acetate|50 mg tablet orally daily for 12 months
5812244|NCT00003571|Genetic|mutation analysis|
5812245|NCT00003571|Genetic|tumor replication error analysis|
5812246|NCT00003382|Biological|filgrastim|
5812247|NCT00003382|Drug|gemcitabine hydrochloride|
5812248|NCT00003382|Drug|topotecan hydrochloride|
5812249|NCT00064792|Drug|Simvastatin Susp.|During the simvastatin phase of the trial, therapy will be initiated at 0.5 mg/kg/day for six weeks and then increased to 1.0 mg/kg/day if adverse side effects are minimal or absent.
5812250|NCT00064792|Drug|OraPlus|During this trial and for two months prior, patients will be maintained on 150 mg/kg/day of dietary cholesterol (150 mg/ml in OraPlus) for the duration of the trial
5812251|NCT00064740|Behavioral|relaxation response|
5812252|NCT00064701|Drug|Tacrolimus Modified Release (MR)|The target range for whole blood tacrolimus trough concentrations was 7 to 16 ng/mL for days 0 through 90, and 5 to 15 ng/mL thereafter.
5812253|NCT00064701|Drug|Tacrolimus|The target range for whole blood tacrolimus trough concentrations was the recommended trough concentration range for Prograf: 7 to 16 ng/mL for days 0 through 90 and 5 to 15 ng/mL thereafter.
5812254|NCT00064701|Drug|cyclosporine microemulsion|The target range for whole blood cyclosporine trough concentrations was 125 to 400 ng/mL for days 0 through 90, and 100 to 300 ng/mL thereafter.
5812255|NCT00064701|Drug|mycophenolate mofetil|Oral
5812256|NCT00064727|Drug|Avandia (Rosiglitazone)|
5812257|NCT00064727|Drug|Avanclia (Rosiqlitazone)|
5812258|NCT00064714|Drug|AC2993 (exenatide)|Dose-escalation beginning with 2.5 μg administered subcutaneously twice per day (BID); then to 2.5 μg four times a day (QID); then to 5 μg four times a day; then to 10 μg four times a day.
5812259|NCT00064714|Drug|daclizumab (immunosuppressive)|2 mg/kg intravenously infused over 30 minutes every month for 12 months
5812260|NCT00064662|Procedure|Burch Modified Tanagho|The Burch colposuspension is a well-established procedure for surgically treating women with stress urinary incontinence. The Burch modified colposuspension suspends the anterior vaginal wall (at the level of the bladder neck) with permanent sutures tied to the iliopectineal ligament.
5812261|NCT00064662|Procedure|Autologous Fascia Sling|The fascial sling is also a well-established procedure for surgically treating women with stress urinary incontinence. The autologous sling procedure places a harvested strip of rectus fascia transvaginally at the level of the proximal urethra. The fascial strip is secured superiorly to the rectus fascia with permanent sutures
5812262|NCT00064649|Device|Transurethral Microwave Thermotherapy (TUMT)|type of minimally invasive surgical therapy for BPH
5812263|NCT00064649|Device|Transurethral Needle Ablation (TUNA) Therapy|type of minimally invasive surgical therapy for BPH
5812264|NCT00064649|Drug|Finasteride and Alfuzosin|finasteride in a daily dose of 5 mg and alfuzosin in a daily dose of 10 mg
5812265|NCT00064636|Drug|VELCADE TM (bortezomib) for Injection, or PS-341|
5812266|NCT00064623|Drug|Capsaicin Dermal Patch|
5812267|NCT00064610|Drug|VELCADE TM (bortezomib) for Injection|
5812268|NCT00063726|Drug|bortezomib|
5812269|NCT00003350|Drug|paclitaxel|Given IV
5812270|NCT00003350|Drug|pegylated liposomal doxorubicin hydrochloride|Given IV
5812271|NCT00003350|Other|laboratory biomarker analysis|Correlative studies
5812272|NCT00003350|Procedure|quality-of-life assessment|Ancillary studies
5812273|NCT00003184|Biological|BCG vaccine|
5812274|NCT00003184|Biological|CD80 breast cancer vaccine|
5812275|NCT00003184|Biological|sargramostim|
5812276|NCT00003045|Device|Hyperthermia|Hyperthermia is delivered by the transrectal ultrasound applicator just prior to XRT, at least one week apart, during the first 4 weeks of XRT. The goal of hyperthermia is CEM T 90 43 greater than or equal to 10 minutes. The maximum applied power duration will be 120 minutes per treatment session
5812277|NCT00003045|Radiation|XRT|external beam radiation to a dose of 4500 cGy to a small pelvic field, followed by a boost to a reduced volume for an additional 2160 cGy. XRT is given daily, 5 days a week for 180 cGy per day. Total radiation dose=6660cGy
5812278|NCT00003008|Drug|indinavir sulfate|
5812279|NCT00003008|Drug|nelfinavir mesylate|
5812280|NCT00003008|Drug|paclitaxel|
5812281|NCT00003008|Drug|ritonavir|
5812282|NCT00003008|Drug|saquinavir mesylate|
5812283|NCT00002965|Biological|Recombinant Interferon Alfa (INF alpha)|Subcutaneous injection Monday through Friday for 8 weeks.
5812284|NCT00064584|Drug|CT53518|
5812285|NCT00064571|Procedure|vocal fold medialization|
5812286|NCT00064571|Procedure|vocal fold reinnervation|
5812287|NCT00064467|Drug|Extended-release bupropion (HCl)|
5812288|NCT00064454|Drug|OPC-6535 Tablets (drug)|
5812289|NCT00064441|Drug|OPC-6535 Tablets (drug)|
5812290|NCT00064415|Drug|arformoterol|Arformoterol inhalation solution, 50 mcg QD
5812291|NCT00064415|Drug|Salmeterol|Salmeterol MDI, 42 mcg BID
5812292|NCT00064402|Drug|arformoterol tartrate inhalation solution|arformoterol 50 mcg QD
5812293|NCT00064402|Drug|arformoterol tartrate inhalation solution|arformoterol 25 mcg BID
5812294|NCT00064402|Drug|arformoterol tartrate inhalation solution|arformoterol 15 mcg BID
5812295|NCT00064402|Drug|Salmeterol|Salmeterol MDI 42 mcg BID
5812296|NCT00064402|Drug|Placebo|Placebo BID
5812297|NCT00064389|Drug|levalbuterol tartrate HFA MDI|levalbuterol MDI 90 mcg QID
5812298|NCT00064389|Drug|racemic albuterol|racemic albuterol HFA MDI 180 mcg QID
5812299|NCT00064376|Drug|paricalcitol|
5812300|NCT00064363|Drug|talampanel|
5812301|NCT00064350|Drug|Sorafenib|"Step 1 (induction): Sorafenib was giventwice daily for two cycles to all patients. Patients with progression (PD) discontinued treatment. Those who responded after two cycles continued treatment up to 1 year or until PD. With response after 1 year, patients were given the option to continue treatment until PD. Patients who were stable after the end of induction were then randomized onto Step 2 to either continue sorafenib or receive placebo.~Step 2 (randomization): Patients with stable disease after induction will be randomized in a double-blinded manner to placebo or sorafenib. If a patient has progressed, the arm will be unblinded. Patients on placebo with PD can then crossover to receive sorafenib; patients with PD on the sorafenib arm will be removed from the study.~Step 3 (crossover): If patients on placebo progressed within 1 year from randomization, they crossed over to the treatment arm and receive sorafenib for up to 1 year or until PD, unacceptable toxicity, or death."
5812302|NCT00064350|Drug|Placebo|Patients randomized to the placebo arm in step 2 continued receiving placebo until disease progression or one year from randomization. Placebo was given orally twice a day (BID).
5812303|NCT00064337|Biological|filgrastim|
5812304|NCT00064337|Drug|cyclophosphamide|
5812305|NCT00064337|Drug|dexamethasone|
5812306|NCT00064337|Drug|melphalan|
5812307|NCT00064337|Drug|thalidomide|
5812308|NCT00064337|Procedure|peripheral blood stem cell transplantation|
5812309|NCT00064324|Drug|perifosine|Given orally
5812310|NCT00064324|Other|laboratory biomarker analysis|Correlative studies
5812311|NCT00064324|Other|pharmacological study|Correlative studies
5812312|NCT00064311|Drug|ravuconazole|
5812313|NCT00064298|Dietary Supplement|fruit and vegetable extracts|Given orally
5812314|NCT00064298|Dietary Supplement|placebo|Given orally
5812315|NCT00064285|Drug|alvocidib|
5812316|NCT00064285|Drug|imatinib mesylate|
5812317|NCT00064272|Drug|ginger extract|Given orally
5812318|NCT00064272|Other|placebo|Given orally
5812319|NCT00064259|Biological|oblimersen sodium|Given IV
5812320|NCT00064259|Drug|cisplatin|Given IV
5812321|NCT00064259|Drug|fluorouracil|Given IV
5812322|NCT00064246|Biological|rituximab|Given IV
5812323|NCT00064246|Radiation|indium In 111 ibritumomab tiuxetan|Given IV
5812324|NCT00064246|Radiation|yttrium Y 90 ibritumomab tiuxetan|Given IV
5812325|NCT00064233|Drug|dasatinib|
5812326|NCT00064220|Drug|soblidotin|
5812327|NCT00064207|Drug|gemcitabine hydrochloride|
5812328|NCT00064207|Procedure|adjuvant therapy|
5812329|NCT00064207|Radiation|radiation therapy|
5812330|NCT00064194|Dietary Supplement|selenium|
5812331|NCT00064194|Dietary Supplement|soy protein isolate|
5812332|NCT00064194|Dietary Supplement|vitamin E|
5812333|NCT00064181|Drug|FOLFIRI regimen|
5812334|NCT00064181|Drug|capecitabine|
5812335|NCT00064181|Drug|celecoxib|
5812336|NCT00064181|Drug|fluorouracil|
5812337|NCT00064181|Drug|irinotecan hydrochloride|
5812338|NCT00064181|Drug|leucovorin calcium|
5812339|NCT00064142|Drug|halofuginone hydrobromide|Applied topically
5812340|NCT00064142|Other|placebo|Applied topically
5812341|NCT00064142|Other|laboratory biomarker analysis|Correlative studies
5812342|NCT00064142|Other|pharmacological study|Correlative studies
5812343|NCT00064129|Biological|Ipilimumab|Given IV
5812344|NCT00064129|Other|Laboratory Biomarker Analysis|Correlative studies
5812345|NCT00064129|Other|Pharmacological Study|Correlative studies
5812346|NCT00064129|Biological|Sargramostim|Given SC
5812347|NCT00064116|Biological|rituximab|Rituximab 375 mg/m² i.v. day 1
5812348|NCT00064116|Drug|CHOP regimen|Cyclophosphamide 750 mg/m² i.v. day 1 Doxorubicin 50 mg/m² i.v. day 1 Vincristine 2 mg (abs.) i.v. day 1 Prednisone 100 mg/d p.o. days 1 to 5 Recycle day 22 Total number of cycles: 6
5812349|NCT00064103|Biological|Ad5CMV-p53 gene|Given intramucosally or as oral rinse
5812350|NCT00064103|Other|laboratory biomarker analysis|Correlative studies
5812351|NCT00064090|Drug|cytarabine|
5812352|NCT00064090|Drug|triapine|
5812353|NCT00064077|Drug|Cisplatin|Given IV
5812354|NCT00064077|Drug|Gemcitabine Hydrochloride|
5812355|NCT00064077|Drug|Paclitaxel|Given IV
5812356|NCT00064077|Other|Quality-of-Life Assessment|Ancillary studies
5812357|NCT00064077|Drug|Topotecan Hydrochloride|Given IV
5812358|NCT00064077|Drug|Vinorelbine Tartrate|Given IV
5812359|NCT00064064|Drug|gemcitabine hydrochloride|
5812360|NCT00064064|Drug|triapine|
5812361|NCT00064051|Drug|gemcitabine hydrochloride|
5812362|NCT00064051|Drug|triapine|
5812363|NCT00064038|Drug|dexamethasone|Given orally
5812364|NCT00064038|Drug|lenalidomide|Given orally
5812365|NCT00064038|Other|placebo|Given orally
5812366|NCT00064025|Other|Laboratory Biomarker Analysis|Correlative studies
5812367|NCT00064025|Drug|Medroxyprogesterone|Given IM
5812368|NCT00064025|Procedure|Therapeutic Conventional Surgery|Undergo surgical hysterectomy
5812369|NCT00064012|Drug|bortezomib|
5812370|NCT00064012|Drug|docetaxel|
5812371|NCT00063999|Drug|Carboplatin|Given IV
5812372|NCT00063999|Drug|Cisplatin|Given IV
5812373|NCT00063999|Drug|Doxorubicin Hydrochloride|Given IV
5812374|NCT00063999|Biological|Filgrastim|Given SC
5812375|NCT00063999|Other|Laboratory Biomarker Analysis|Correlative studies
5812376|NCT00063999|Drug|Paclitaxel|Given IV
5822957|NCT00002072|Drug|Epoetin alfa|
5812377|NCT00063999|Biological|Pegfilgrastim|Given SC
5812378|NCT00063999|Other|Quality-of-Life Assessment|Ancillary studies
5812379|NCT00063986|Procedure|Minimally invasive esophagectomy (MIE)|Within 4 weeks of registration patients will undergo minimally invasive esophagectomy (MIE). However, there will be up to 5 months allowed between registration and MIE for those patients needing neoadjuvant therapy prior to undergoing MIE.
5812380|NCT00063973|Drug|cilengitide|Given IV
5812381|NCT00063973|Other|laboratory biomarker analysis|Correlative studies
5812382|NCT00063960|Drug|floxuridine|
5812383|NCT00063960|Drug|irinotecan hydrochloride|
5812384|NCT00063947|Drug|erlotinib hydrochloride|Given orally
5812385|NCT00063947|Drug|gemcitabine hydrochloride|Given IV
5812386|NCT00063947|Radiation|radiation therapy|Undergo radiotherapy
5812387|NCT00063947|Other|laboratory biomarker analysis|Correlative studies
5812388|NCT00063934|Biological|oblimersen sodium|Given IV
5812389|NCT00063934|Drug|doxorubicin hydrochloride|Given IV
5812390|NCT00063934|Drug|docetaxel|Given IV
5812391|NCT00063934|Biological|filgrastim|Given SC
5812392|NCT00063934|Biological|pegfilgrastim|Given SC
5812393|NCT00063934|Procedure|therapeutic conventional surgery|Undergo surgical resection
5812394|NCT00063934|Other|pharmacological study|Optional correlative studies
5812395|NCT00063934|Other|laboratory biomarker analysis|Optional correlative studies
5812396|NCT00063895|Drug|erlotinib hydrochloride|Given PO
5812397|NCT00063895|Other|pharmacological study|Correlative studies
5812398|NCT00063895|Other|pharmacogenomic studies|Correlative studies
5812399|NCT00063895|Other|laboratory biomarker analysis|Correlative studies
5812400|NCT00063882|Radiation|Brachytherapy (100/110)|100 Gy Palladium-103 (P-102) or 110 Gy Iodine-125 (I-125) seeds within 2-4 weeks of completion of external beam radiotherapy.
5812401|NCT00063882|Radiation|Brachytherapy (125/145)|125 Gy Palladium-103 (P-103) or 145 Gy Iodine-125 (I-125) seeds within 4 weeks of study entry.
5812402|NCT00063882|Radiation|External Beam Radiation Therapy|Total dose of 45 Gy to the prostate and seminal vesicles as a daily dose of 1.8 Gy given 5 times per week. The prescribed dose is defined at the International Commission of Radiation Units and Measurements (ICRU) reference point. Both 3D-conformal radiation therapy (3DCRT) and intensity modulated radiation therapy (IMRT) are permitted.
5812403|NCT00063869|Drug|Etanercept|
5812404|NCT00023907|Drug|paclitaxel|
5812405|NCT00005940|Radiation|iodine I 131 monoclonal antibody BC8|Given IV
5812406|NCT00005940|Drug|busulfan|Given PO
5812407|NCT00005940|Drug|cyclophosphamide|Given IV
5812408|NCT00005940|Procedure|allogeneic bone marrow transplantation|Undergo allogeneic PBSC or bone marrow transplant
5812409|NCT00005940|Procedure|allogeneic hematopoietic stem cell transplantation|Undergo allogeneic PBSC or bone marrow transplant
5812410|NCT00005940|Procedure|peripheral blood stem cell transplantation|Undergo allogeneic PBSC or bone marrow transplant
5812411|NCT00005940|Drug|cyclosporine|Given IV or PO
5812412|NCT00005940|Drug|methotrexate|Given IV
5812413|NCT00005940|Other|laboratory biomarker analysis|Correlative studies
5812414|NCT00003211|Biological|filgrastim|
5812415|NCT00003211|Drug|amifostine trihydrate|
5812416|NCT00003211|Drug|cisplatin|
5812417|NCT00003211|Drug|cyclophosphamide|
5812418|NCT00003211|Drug|vincristine sulfate|
5812419|NCT00003211|Procedure|peripheral blood stem cell transplantation|
5812420|NCT00003211|Radiation|radiation therapy|
5812421|NCT00002878|Drug|dexamethasone|
5812422|NCT00002878|Drug|doxorubicin hydrochloride|
5812423|NCT00002878|Drug|valspodar|
5812424|NCT00002878|Drug|vincristine sulfate|
5812425|NCT00063856|Biological|Wetvax (APSV)|
5812426|NCT00063843|Biological|Recombinant Protective Antigen, Anthrax Vaccine Adsorbed|
5812427|NCT00063830|Drug|Alicaforsen|
5812428|NCT00063817|Drug|Conditioning Regimen|Cyclophosphamide 60 mg per kilogram (kg) of body weight per day intravenously (IV) on days -5 and -4 with respect to transplantation; humanized anti-CD2 monoclonal antibody (MEDI-507) 0.6 mg per kg on days -1, 0, and 1 (after test dose of 0.1 mg per kg on day -2); and cyclosporine A 5 mg per kg IV and thymic irradiation (700 cGy) on day -1. Hemodialysis was performed before and 14 hours after each dose of cyclophosphamide.Kidney transplantation was followed by IV infusion of donor bone marrow. Oral cyclosporine A was administered postoperatively, 8 to 12 mg per kg per day, with target trough blood levels of 250 to 350 ng per milliliter; the dose was tapered and discontinued over a period of several months. Protocol amendment that applied to participant 4 and 5: rituximab, 375 mg per square meter of body-surface area days -7 and -2; and prednisone, 2 mg per kg per day starting on the day of transplantation with tapering over the next 10 days.
5812429|NCT00063804|Drug|Ritonavir|
5812430|NCT00063804|Drug|AMD070|
5812431|NCT00063791|Drug|Bortezomib|
5812432|NCT00063778|Biological|AVX101|Alphavirus replicon particle vaccine expressing HIV Gag antigen
5812433|NCT00063778|Other|placebo|phosphate buffered saline, pH 7.2, HSA, sodium gluconate, and sucrose
5812434|NCT00063752|Drug|PI-0824|
5812435|NCT00045357|Biological|therapeutic autologous lymphocytes|
5812436|NCT00042900|Drug|pyroxamide|
5812437|NCT00040820|Drug|oxaliplatin|
5812438|NCT00039169|Drug|ortataxel|
5812439|NCT00036660|Drug|SarCNU|
5812440|NCT00033384|Drug|CI-1040|
5812441|NCT00002752|Radiation|iodine I 131 monoclonal antibody 81C6|
5812442|NCT00002582|Drug|CMF regimen|
5812443|NCT00002582|Drug|cyclophosphamide|
5812444|NCT00002582|Drug|doxorubicin hydrochloride|
5812445|NCT00002582|Drug|fluorouracil|
5812446|NCT00002582|Drug|goserelin acetate|
5812447|NCT00002582|Drug|leuprolide acetate|
5812448|NCT00002582|Drug|methotrexate|
5812449|NCT00002582|Drug|tamoxifen citrate|
5812450|NCT00002582|Procedure|oophorectomy|
5812451|NCT00002582|Radiation|radiation therapy|
5812452|NCT00063765|Drug|Ciliary Neurotrophic Factor Implant NT-501|
5812453|NCT00063713|Drug|VELCADE TM (bortezomib) for Injection|
5812454|NCT00063700|Procedure|reducing exposure to marketing pressures|
5812455|NCT00063687|Drug|Oxypurinol|
5812456|NCT00063674|Behavioral|Nutrition Education|
5812457|NCT00063674|Behavioral|After-school dance class|
5812458|NCT00063648|Biological|EBV-specific autologous CTL|
5812459|NCT00063635|Drug|Metformin|500 mg, twice daily
5812460|NCT00063635|Dietary Supplement|Vitamin E|400 IU, twice daily
5812461|NCT00063635|Drug|Matching placebo|Twice daily
5812462|NCT00063622|Drug|Pioglitazone|30 mg daily
5812463|NCT00063622|Dietary Supplement|Vitamin E|800 IU daily
5812464|NCT00063622|Drug|Matching placebo|Daily
5812465|NCT00063609|Drug|zoledronic acid|
5812466|NCT00063596|Drug|Vitamin A supplementation|
5812467|NCT00063583|Drug|Pirfenidone|Pirfenidone will be administered orally at 1200 or 2400 mg day in divided doses
5812468|NCT00063570|Drug|Pemetrexed|500 mg/m2, intravenous (IV), every 14 days, until disease progression
5812469|NCT00063570|Drug|Gemcitabine|1500 mg/m2, intravenous (IV), every 14 days, until disease progression
5812470|NCT00063570|Drug|Gemcitabine|1000 mg/m2, intravenous (IV), on Days 1 and 8 of 21-day cycle, until disease progression
5812471|NCT00063570|Drug|Pemetrexed|500 mg/m2, intravenous (IV), every 21 days, until disease progression
5812472|NCT00063323|Drug|Bupropion|
5812473|NCT00033319|Dietary Supplement|folic acid|
5812474|NCT00033319|Drug|acetylsalicylic acid|
5812475|NCT00031954|Drug|carboplatin|
5812476|NCT00031954|Drug|gemcitabine hydrochloride|
5812477|NCT00031954|Drug|paclitaxel|
5812478|NCT00031889|Drug|Exemestane|Exemestane
5812479|NCT00031889|Drug|Exemestane+bicalutamide|Exemestane as in arm I and oral bicalutamide once daily
5812480|NCT00031668|Radiation|radiation therapy|
5812481|NCT00028938|Biological|epoetin alfa|
5812482|NCT00028938|Drug|carboplatin|
5812483|NCT00028938|Drug|paclitaxel|
5812484|NCT00028938|Radiation|radiation therapy|
5812485|NCT00063479|Drug|Zoledronic Acid|
5812486|NCT00063453|Dietary Supplement|Vitamin E|vitamin E (400 IU/day all rac-α-tocopheryl acetate)
5812487|NCT00063453|Dietary Supplement|Selenium|selenium (200 μg/d L-selenomethionine)
5812488|NCT00063453|Dietary Supplement|Vitamin E placebo|placebo
5812489|NCT00063453|Dietary Supplement|Selenium placebo|placebo
5812490|NCT00028925|Biological|filgrastim|
5812491|NCT00028925|Drug|carboplatin|
5812492|NCT00028925|Drug|topotecan hydrochloride|
5812493|NCT00028925|Radiation|WBRT|
5812494|NCT00028613|Radiation|iodine I 131 monoclonal antibody Lym-1|
5812495|NCT00063427|Drug|MAC-321|
5812496|NCT00063414|Drug|Alicaforsen|
5812497|NCT00063401|Biological|Cetuximab:|400 mg/m2 loading dose, 250 mg/m2 weekly, six 21-day cycles
5812498|NCT00063401|Drug|Paclitaxel|175 mg/m2 Day 1, six 21-day cycles
5812499|NCT00063401|Drug|Carboplatin|AUC = 6 Day1, six 21-day cycles
5812500|NCT00063388|Biological|Cetuximab|Cetuximab 400 mg/m2 intravenously (IV) (over 120 minutes) on Day 1 of Cycle 1. followed by weekly doses of 250 mg/m2 (over 60 minutes).
5812501|NCT00063375|Behavioral|Computer Based Cognitive Behavioral Therapy|
5812502|NCT00063362|Drug|Lithium|Lithium monotherapy was initiated at 450 mg once daily and titrated slowly over three weeks to a minimum blood level of 0.5 milliequivalent /L (mEq/L).
5812503|NCT00063362|Drug|Lamotrigine|Patients were assigned in a one to one ratio to adjunctive lamotrigine versus placebo after stratification for illness type (bipolar I versus bipolar II), historical response to lithium (response versus non-response), and length of current exposure to combination treatment with lithium and divalproex (< 2 months versus ≥ 2 months). During Phase 2, patients were continued on the same doses of lithium and divalproex as during the open-label treatment phase and equal capsules of double-blind lamotrigine or matching placebo were gradually added per a structured dosing schedule up to a minimum dose of 150 mg and a maximum dose of 200 mg per day.
5812504|NCT00063362|Drug|Divalproex|Divalproex was then initiated at 250 mg twice daily and increased slowly over five weeks to a minimum blood level of 50 μg/mL.
5812505|NCT00063362|Drug|Placebo|Patients were assigned in a one to one ratio to adjunctive lamotrigine versus placebo after stratification for illness type (bipolar I versus bipolar II), historical response to lithium (response versus non-response), and length of current exposure to combination treatment with lithium and divalproex (< 2 months versus ≥ 2 months). During Phase 2, patients were continued on the same doses of lithium and divalproex as during the open-label treatment phase and equal capsules of double-blind lamotrigine or matching placebo were gradually added per a structured dosing schedule up to a minimum dose of 150 mg and a maximum dose of 200 mg per day.
5812506|NCT00063336|Behavioral|Cognitive Remediation|A computerized cognitive rehabilitation treatment with day-program activities
5812507|NCT00063336|Behavioral|Computer-skills training|A computerized cognitive rehabilitation treatment with day-program activities
5812508|NCT00030446|Drug|carboplatin|
5812509|NCT00030446|Drug|erlotinib hydrochloride|
5812510|NCT00028483|Drug|cBR96-doxorubicin immunoconjugate|
5812511|NCT00028483|Drug|docetaxel|
5812512|NCT00006968|Biological|filgrastim|
5812513|NCT00006968|Drug|cyclosporine|
5812514|NCT00006968|Drug|pentostatin|
5812515|NCT00006968|Procedure|allogeneic bone marrow transplantation|
5812516|NCT00006968|Procedure|peripheral blood stem cell transplantation|
5812517|NCT00003352|Drug|cyclophosphamide|600 mg/m2, IV, every 3 weeks
5812518|NCT00003352|Drug|Taxotere|60 mg/m2, IV, every 3 weeks
5812519|NCT00003352|Drug|Adriamycin|60 mg/m2, IV, every 3 weeks
5812520|NCT00063310|Drug|Leuprolide acetate|
5812521|NCT00063297|Drug|R209130|
5812522|NCT00040729|Genetic|mutation analysis|
5812523|NCT00063284|Device|Magstim Rapid Magnetic Stimulator|
5812524|NCT00063258|Drug|Tarceva (OSI-774)|150 mg/day, starting day 1 and stopping night prior to surgery.
5812725|NCT00062322|Radiation|radiation therapy|
5812525|NCT00063258|Drug|Paclitaxel|Planned dose of 200 mg/m^2 continuous IV infusion over 3 hours on Day 1 of each 21-day cycle.
5812526|NCT00063258|Drug|Carboplatin|Dose of AUC = 6 mg/ml × min began within 60 minutes following completion of paclitaxel infusion, infused over 15-30 minutes on Day 1 of Cycle 1 of each 21-day cycle, and then on Day 1 of each subsequent cycle according to institutional standards.
5812527|NCT00063219|Drug|MAC-321|
5812528|NCT00063206|Drug|DVS-233 SR|
5812529|NCT00063193|Drug|minocycline|
5812530|NCT00063193|Drug|creatine|
5812531|NCT00063154|Drug|Pertuzumab|Pertuzumab was supplied as a single-use liquid formulation.
5812532|NCT00063141|Drug|cetuximab|Vial, IV, 400 mg/m² week 1 then 250 mg/m², weekly, until PD/Toxicity/Pt-PI Decision
5812533|NCT00063141|Drug|Irinotecan|Vial, IV, 350 mg/m², Q 3 Weeks, Until PD/Toxicity/Pt-PI Decision
5812534|NCT00063141|Drug|Irinotecan|Vial, IV, 350 mg/m², Q 3 Weeks, Until PD/Toxicity/Pt-PI Decision
5812535|NCT00063128|Drug|insulin|"Administer subcutaneous regular human insulin 30 to 60 minutes before meals, or administer insulin lispro within 15 minutes before meals.~Inject into abdomen only."
5812536|NCT00063128|Drug|human insulin inhalation powder (HIIP)|"Administer HIIP within 15 minutes before meals.~Administer doses in one-capsule increments equivalent to approximately 2 IU or 6 IU of subcutaneous insulin.~Target treatment goals during the treatment sequence are the same as for patients using preprandial injectable insulin"
5812537|NCT00030797|Drug|Irinotecan 70 mg/m2|Irinotecan i.v. 70 mg/m2, day 1, 8, 15, 22, 29
5812538|NCT00030797|Drug|Irinotecan 240 mg/m2|Irinotecan i.v. 240 mg/m2 day 1 and day 22
5812539|NCT00026520|Biological|recombinant interferon alfa|
5812540|NCT00026520|Drug|thalidomide|
5812541|NCT00026364|Drug|fluorouracil|
5812542|NCT00026364|Drug|gefitinib|
5812543|NCT00026364|Drug|irinotecan hydrochloride|
5812544|NCT00026364|Drug|leucovorin calcium|
5812545|NCT00026351|Biological|rituximab|
5812546|NCT00026351|Drug|pentostatin|
5812547|NCT00025571|Drug|HPPH|
5812548|NCT00006013|Drug|semaxanib|
5812549|NCT00004037|Drug|docetaxel|
5812550|NCT00003054|Drug|paclitaxel|
5812551|NCT00063232|Drug|Metformin|After complete medical evaluation and liver biopsy, patients who qualified for therapy were started on metformin in an initial dose of 500 mg once daily. After 2 weeks, the dose was increased to 500 mg twice daily and after 4 weeks to the full dose of 1000 mg twice daily. Subsequent dose reductions were carried out based on tolerance, with particular attention to gastrointestinal upset and abdominal bloating. Patients were seen in the out-patient clinic, had a brief medical history and examination and routine blood tests at 2 and 4 weeks after enrolment and every 4 weeks thereafter. The oral and intravenous glucose tolerance tests were repeated after 40 and 44 weeks respectively and liver biopsy and imaging tests at 48 weeks. Metformin was discontinued after 48 weeks in patients without diabetes on the pre-treatment evaluation.
5812552|NCT00063102|Drug|ABT-751|
5812553|NCT00063089|Drug|S. aureus Immune Globulin Intravenous (Human) 5%|
5812554|NCT00063076|Drug|Targretin Gel 1%|Alopecia lesions on one-half of the head including facial hair treated, and other half on head serves as control (untreated). Starting dose once every day till Week 3 then escalate to twice a day.
5812555|NCT00063050|Behavioral|Physical activity and nutrition intervention|
5812556|NCT00063037|Behavioral|Behavioral modification - nutrition education|
5812557|NCT00063024|Behavioral|Increased calcium intake|
5812558|NCT00063024|Behavioral|Weight-bearing physical activity|
5812559|NCT00063011|Behavioral|Calcium rich diet|
5812560|NCT00063011|Behavioral|Weight bearing exercise|
5812561|NCT00025545|Drug|cyclophosphamide|
5812562|NCT00025545|Drug|methotrexate|
5812563|NCT00025545|Procedure|peripheral blood stem cell transplantation|
5812564|NCT00025545|Radiation|radiation therapy|
5812565|NCT00024323|Drug|cisplatin|
5812566|NCT00024323|Drug|triapine|
5812567|NCT00024310|Dietary Supplement|folic acid|
5812568|NCT00024310|Drug|lometrexol|
5812569|NCT00024310|Drug|paclitaxel|
5812570|NCT00024141|Drug|fluorouracil|
5812571|NCT00024141|Drug|irinotecan hydrochloride|
5812572|NCT00023933|Drug|iodine I 131 monoclonal antibody CC49-deltaCH2|Given IV
5812573|NCT00062985|Behavioral|Mail-based weight loss intervention|
5812574|NCT00062985|Behavioral|Phone-based weight loss intervention|
5812575|NCT00062972|Drug|donepezil|
5812576|NCT00062972|Drug|glucose|
5812577|NCT00062959|Behavioral|Going Places: School program to prevent problem behavior|
5812578|NCT00062907|Biological|Recombinant DNA- pVAX/L523S|
5812579|NCT00062907|Biological|Recombinant adenovirus- Ad/L523S|
5812580|NCT00062894|Drug|Iodine I 131 Tositumomab|
5812581|NCT00062946|Drug|(18F)fallypride|
5812582|NCT00062933|Procedure|Laparotomy|
5812583|NCT00062881|Drug|Intrathecal Mafosfamide|
5812584|NCT00062868|Biological|LMP1/2 CTLs (ALCI - Group A)|"Each patient will receive 2 injections, 14 days apart, according to the following dosing schedules:~Dose Level One~Day 0: 2 x 10^7 cells/m2; Day 14: 2 x 10^7 cells/m2~Dose Level Two~Day 0: 2x10^7 cells/m2; Day 14: 1x10^8 cells/m2~Dose Level Three~Day 0: 1x10^8 cells/m2; Day 14: 2x10^8 cells/m2"
5812585|NCT00062868|Biological|LMP1/2 CTLs (ALCI - Group B)|"Each patient will receive 2 injections, 14 days apart, according to the following dosing schedules:~Dose Level One~Day 0: 2x10^7 cells/m2; Day 14: 2x10^7 cells/m2~Dose Level Two~Day 0: 2x10^7 cells/m2; Day 14: 1x10^8 cells/m2~Dose Level Three~Day 0: 1x10^8 cells/m2; Day 14: 2x10^8 cells/m2"
5812586|NCT00062868|Biological|LMP1/2 CTLs (ALCI - Group C)|"Each patient will receive 2 injections, 14 days apart, according to the following dosing schedules:~Dose Level One~Day 0: 2x10^7 cells/m2; Day 14: 2x10^7 cells/m2~Dose Level Two~Day 0: 2x10^7 cells/m2; Day 14: 1x10^8 cells/m2~Dose Level Three~Day 0: 1x10^8 cells/m2; Day 14: 2x10^8 cells/m2"
5812587|NCT00062868|Biological|LMP2 CTLs (ALSCER - Group A)|"Each patient will receive 2 injections, 14 days apart, according to the following dosing schedules:~Dose Level One~Day 0: 2 x 10^7 cells/m2; Day 14: 2 x 10^7 cells/m2~Dose Level Two~Day 0: 2x10^7 cells/m2; Day 14: 1x10^8 cells/m2~Dose Level Three~Day 0: 1x10^8 cells/m2; Day 14: 2x10^8 cells/m2"
5812726|NCT00062309|Radiation|radiation therapy|
5812588|NCT00062868|Biological|LMP2 CTLs (ALSCER - Group B)|"Each patient will receive 2 injections, 14 days apart, according to the following dosing schedules:~Dose Level One~Day 0: 2x10^7 cells/m2; Day 14: 2x10^7 cells/m2~Dose Level Two~Day 0: 2x10^7 cells/m2; Day 14: 1x10^8 cells/m2~Dose Level Three~Day 0: 1x10^8 cells/m2; Day 14: 2x10^8 cells/m2"
5812589|NCT00062868|Biological|LMP2 CTLs (ALSCER - Group C)|"Each patient will receive 2 injections, 14 days apart, according to the following dosing schedules:~Dose Level One~Day 0: 2x10^7 cells/m2; Day 14: 2x10^7 cells/m2~Dose Level Two~Day 0: 2x10^7 cells/m2; Day 14: 1x10^8 cells/m2~Dose Level Three~Day 0: 1x10^8 cells/m2; Day 14: 2x10^8 cells/m2"
5812590|NCT00062868|Biological|LMP1/2 CTLs (ALCI - Expansion - Group A)|"Each patient will receive 2 injections, 14 days apart, according to the following dosing schedules:~Dose Level One~Day 0: 2 x 10^7 cells/m2; Day 14: 2 x 10^7 cells/m2"
5812591|NCT00062868|Biological|LMP1/2 CTLs (ALCI - Expansion Group B)|"Each patient will receive 2 injections, 14 days apart, according to the following dosing schedules:~Dose Level One~Day 0: 2x10^7 cells/m2; Day 14: 2x10^7 cells/m2"
5812592|NCT00062868|Biological|LMP1/2 CTLs (ALCI - Expansion Group C)|"Each patient will receive 2 injections, 14 days apart, according to the following dosing schedules:~Dose Level One~Day 0: 2x10^7 cells/m2; Day 14: 2x10^7 cells/m2"
5812593|NCT00062855|Procedure|Skin Biopsy|
5812594|NCT00062855|Genetic|Gene Modified Neuroblastoma Cells|"The first two injections will be given at week 1 and week 2 (i.e., separated by one week). Patients will then have a two-week rest and the remaining two injections will be given (again separated by one week) at week 4 and week 5.~A complete evaluation for evidence of toxicity and response will be performed at week 8 (after a 3 week rest).~At the 8 week (month 2) evaluation, in the absence of progressive disease requiring therapy without excessive toxicity and if more transduced cells are available, the patient will have the option to receive four additional SC injections each separated by 1 month at the higher of the two dosage levels they originally received."
5812595|NCT00062842|Drug|Irinotecan|
5812596|NCT00062829|Behavioral|Teen Driving: Program for parents|A behavioral intervention targeting driving risks unique to young drivers, including completing a behavioral contract, was administered to the intervention group. The control group received safety information appropriate for new drivers.
5812597|NCT00062816|Drug|ISIS 14803, peginterferon alfa, ribavirin|
5812598|NCT00002643|Biological|filgrastim|
5812599|NCT00002643|Drug|amifostine trihydrate|
5812600|NCT00002643|Drug|cyclophosphamide|
5812601|NCT00002643|Drug|doxorubicin hydrochloride|
5812602|NCT00002643|Drug|etoposide|
5812603|NCT00002643|Drug|ifosfamide|
5812604|NCT00002643|Drug|topotecan hydrochloride|
5812605|NCT00002643|Drug|vincristine sulfate|
5812606|NCT00002643|Procedure|conventional surgery|
5812607|NCT00002643|Radiation|low-LET cobalt-60 gamma ray therapy|
5812608|NCT00002643|Radiation|low-LET electron therapy|
5812609|NCT00002643|Radiation|low-LET photon therapy|
5812610|NCT00062803|Drug|SR34006|
5812611|NCT00062803|Drug|(LMW)heparin|
5812612|NCT00062803|Drug|Warfarin VKA|
5812613|NCT00062803|Drug|Acenocoumarol VKA|
5812614|NCT00062790|Drug|Dutasteride|
5812615|NCT00027612|Drug|carmustine|IV
5812616|NCT00027612|Drug|irinotecan hydrochloride|IV
5812617|NCT00027612|Radiation|radiation therapy|
5812618|NCT00025376|Drug|PS-341|
5812619|NCT00025376|Procedure|Tumor Biopsy|
5812620|NCT00023868|Drug|FOLFIRI regimen|
5812621|NCT00023868|Drug|cisplatin|
5812622|NCT00023868|Drug|doxorubicin hydrochloride|
5812623|NCT00023868|Drug|fluorouracil|
5812624|NCT00023868|Drug|irinotecan hydrochloride|
5812625|NCT00023868|Drug|leucovorin calcium|
5812626|NCT00023868|Drug|mitomycin C|
5812627|NCT00022594|Drug|liposomal lurtotecan|
5812628|NCT00022529|Drug|BMS-214662|Given IV
5812629|NCT00022529|Biological|trastuzumab|Given IV
5812630|NCT00022529|Other|pharmacological study|Correlative studies
5812631|NCT00062764|Drug|Actos (Pioglitazone)|Pts receive drug in a dose of 15 mg daily for at least 1 year; the dose is escalated to 30 mg daily if serum ALT levels do not fall to normal by the 1 year pt; if pts have a biochemical response, drug is continued for 3 years,
5812632|NCT00062751|Drug|Letrozole / Temsirolimus (CCI-779)|Letrozole 2.5 mg daily + Temsirolimus (CCI-779) 10 mg daily
5812633|NCT00062751|Drug|Letrozole / Temsirolimus (CCI-779)|Letrozole 2.5 mg daily + Temsirolimus (CCI-779) intermittent 30 mg daily for five days every 2 weeks
5812634|NCT00062751|Drug|Letrozole|Letrozole 2.5 mg daily
5812635|NCT00062738|Drug|paroxetine|Paroxetine CR 12.5 - 25 mg q hs
5812636|NCT00062738|Drug|Nortriptyline|nortriptyline 25 - 75 mg q hs
5812637|NCT00062738|Other|placebo|matching placebo
5812638|NCT00062699|Drug|Zemplar (paricalcitol injection)|
5812639|NCT00062699|Drug|Calcijex|
5812640|NCT00062712|Drug|Allogeneic Bone Marrow, Anti-Thymocyte Globulin (Sangstat) & Sirolimus (Wyeth-Ay|
5812641|NCT00062686|Drug|GW572016|
5812642|NCT00062673|Drug|Duloxetine|
5812643|NCT00062673|Drug|Placebo|
5812644|NCT00062660|Drug|Tipranavir|Tipranavir 250 mg soft elastic capsules
5812645|NCT00062647|Drug|Telavancin|Telavancin 10mg/kg/day IV every 24 hrs for up to 14 days
5812646|NCT00062647|Drug|Vancomycin, nafcillin, oxacillin, or cloxacillin|Vancomycin 1 Gram every 12 hr IV (intravenously) OR nafcillin, oxacillin, or cloxacillin 2 Grams every 6 hr IV (intravenously) for up to 14 days.
5812647|NCT00062634|Behavioral|Female condom skills training|
5812648|NCT00062621|Procedure|Combined bone marrow and kidney transplant|
5812649|NCT00062608|Behavioral|Written self-disclosure|
5812650|NCT00062595|Drug|phylloquinone (K1)|
5812651|NCT00062595|Drug|menatetranone (MK4)|
5812652|NCT00062569|Behavioral|Bathing Support Intervention (BSI)|Bathing Support Intervention - Review of caregiver current practices and perceptions and care recipient behavioral symptoms associated with bathing with pattern analysis based on observation; skill building for bathing and communication techniques; coaching for implementation
5812727|NCT00062296|Biological|rituximab|
5812728|NCT00062296|Drug|epirubicin hydrochloride|
5812653|NCT00062569|Behavioral|Caregiver reminiscence with coaching|"BSI plus Reminiscence - BSI as above plus caregiver interview to ascertain pleasant long-term memories (e.g. stories, pictures, music) developed into a crib sheet for caregiver use conversationally prior to and during the bath"
5812654|NCT00062556|Drug|Niacin Extended Release and Lovastatin Tablets|
5812655|NCT00062543|Procedure|Hepatic artery infusion of CD34+ cells|Donor's cells infused directly into liver through a groin catheter (hepatic artery).
5812656|NCT00062543|Device|Cobe Spectra|Mononuclear cells (MNC) collected by continuous-flow centrifugation using a blood cell separator (Cobe Spectra).
5812657|NCT00062530|Biological|SCBaL/M9|Oral recombinant Salmonella typhi HIV-1 gp120 vaccine
5812658|NCT00062504|Drug|Talampanel|10mg, 25 mg, 35 mg, 50 mg, 75mg TID for 3 weeks
5812659|NCT00062491|Drug|Karenitecin (BNP1350)|Karenitecn (1.0 mg/m2) administered as a single daily 60-minute intravenous infusion for 5 consecutive days repeated every 21 days (1 treatment cycle). Patients who respond (CR< PR, SD) can continue treatment for 6 cycles, unless unacceptable toxicity develops. Treatment will be discontinued if progressive disease or unacceptable toxicity develops.
5812660|NCT00062478|Drug|Karenitecin (BNP1350)|Karenitecin 1.0 mg/m2 administered as a single 60-minute IV infusion daily for five consecutive days. The cycle is repeated every 21 days until occurrence of progressive disease or unacceptable toxicity.
5812661|NCT00022009|Drug|gemcitabine hydrochloride|
5812662|NCT00018954|Drug|asparaginase|
5812663|NCT00018954|Drug|cyclophosphamide|
5812664|NCT00018954|Drug|cytarabine|
5812665|NCT00018954|Drug|daunorubicin hydrochloride|
5812666|NCT00018954|Drug|doxorubicin hydrochloride|
5812667|NCT00018954|Drug|etoposide|
5812668|NCT00018954|Drug|ifosfamide|
5812669|NCT00018954|Drug|mercaptopurine|
5812670|NCT00018954|Drug|methotrexate|
5812671|NCT00018954|Drug|prednisone|
5812672|NCT00018954|Drug|vincristine sulfate|
5812673|NCT00018954|Procedure|conventional surgery|
5812674|NCT00018954|Radiation|radiation therapy|
5812675|NCT00017446|Drug|CP4071|
5812676|NCT00017394|Biological|bevacizumab|Given IV
5812677|NCT00017394|Drug|vinorelbine tartrate|Given IV
5812678|NCT00017394|Other|laboratory biomarker analysis|Correlative studies
5812679|NCT00017316|Drug|semaxanib|
5812680|NCT00017316|Drug|thalidomide|
5812681|NCT00062582|Drug|Roflumilast|
5812682|NCT00016107|Drug|estramustine phosphate sodium|Given orally
5812683|NCT00016107|Drug|docetaxel|Given IV
5812684|NCT00016107|Biological|bevacizumab|Given IV
5812685|NCT00016107|Other|laboratory biomarker analysis|Correlative studies
5812686|NCT00014664|Biological|apolizumab|
5812687|NCT00014534|Biological|filgrastim|6 mg sub Q
5812688|NCT00014534|Drug|cisplatin|60 mg/sq m IV
5812689|NCT00014534|Drug|doxorubicin hydrochloride|50 mg/ sq m IV
5812690|NCT00014534|Drug|gemcitabine hydrochloride|1000 mg/ sq m IV for Gem + cis arm and 2000 mg/sq m IV for gem + dox + peg arm
5812691|NCT00014170|Drug|gefitinib|Given orally
5812692|NCT00014170|Other|pharmacological study|Correlative studies
5812693|NCT00014170|Other|laboratory biomarker analysis|Correlative studies
5812694|NCT00014170|Other|questionnaire administration|Ancillary studies
5812695|NCT00014170|Procedure|quality-of-life assessment|Ancillary studies
5812696|NCT00012155|Biological|NV1020|
5812697|NCT00062465|Drug|TwHF|
5812698|NCT00062439|Drug|cisplatin|During induction:50 mg/m2,IV on Days 1, 8, 29 & 36. In any appropriate vehicle over 60 minutes
5812699|NCT00062439|Drug|docetaxel|During consolidation: 75 mg/m2 IV on Day 1, every 21 days for 3 cycles over 60 minutes
5812700|NCT00062439|Drug|etoposide|During induction: 50 mg/m2, IV on Days 1 - 5 Days 29 - 33. In 250 ml of NS over 60 minutes.
5812701|NCT00062439|Procedure|conventional surgery|If, based upon the evaluation in Section 7.4a, there is no evidence of progression (see Section 10.2d for definition), patients will proceed to the next appropriate step: Registration #2 and surgery followed by Registration #3 and additional chemotherapy (Sections 7.5 and 7.6). Response determinations (CR,PR, SD) will be required. If criteria for progressive measurable or nonmeasurable disease (see Section 10.0) are met, the patient will then be removed from protocol treatment and receive follow-up according to the schedule. Surgery will be performed 3 - 7 weeks after completion of chemoradiotherapy.
5812702|NCT00062439|Radiation|radiation therapy|Radiotherapy is to begin within 24 hours following the start of chemotherapy. Day 1 of radiotherapy must be a Monday, Tuesday or Wednesday, but no later in the week to insure simultaneous therapy for the majority of each chemotherapy cycle. The total dose to the prescription point will be 4,500 cGy given in 25 fractions. The patient will be treated with one fraction per day with all fields treated per day. 180 cGy will be delivered to the isocenter.
5812703|NCT00062426|Biological|bevacizumab|
5812704|NCT00062426|Drug|capecitabine|
5812705|NCT00062426|Drug|fluorouracil|
5812706|NCT00062426|Drug|leucovorin calcium|
5812707|NCT00062426|Drug|oxaliplatin|
5812708|NCT00062400|Procedure|psychosocial assessment and care|
5812709|NCT00062387|Drug|perifosine|
5812710|NCT00062374|Drug|Cisplatin|Given IV
5812711|NCT00062374|Procedure|Computed Tomography|Undergo FDG and FLT PET/CT
5812712|NCT00062374|Radiation|Fludeoxyglucose F-18|Undergo FDG-PET/CT
5812713|NCT00062374|Other|Fluorothymidine F-18|Undergo FLT-PET/CT
5812714|NCT00062374|Drug|Irinotecan Hydrochloride|Given IV
5812715|NCT00062374|Procedure|Positron Emission Tomography|Undergo FDG and FLT PET/CT
5812716|NCT00062374|Procedure|Therapeutic Conventional Surgery|Undergo radical subtotal or total gastrectomy with lymph node dissection
5812717|NCT00062348|Drug|boronophenylalanine-fructose complex|
5812718|NCT00062348|Drug|sodium borocaptate|
5812719|NCT00062348|Procedure|conventional surgery|
5812720|NCT00062335|Radiation|radiation therapy|
5812721|NCT00062322|Drug|cisplatin|
5812722|NCT00062322|Drug|irinotecan hydrochloride|
5812723|NCT00062322|Procedure|conventional surgery|
5812724|NCT00062322|Procedure|neoadjuvant therapy|
5812733|NCT00062270|Drug|gemcitabine hydrochloride|
5812734|NCT00062270|Procedure|conventional surgery|
5812735|NCT00062270|Procedure|neoadjuvant therapy|
5812736|NCT00062270|Radiation|radiation therapy|
5812737|NCT00062257|Drug|irofulven|
5812738|NCT00062244|Biological|oblimersen sodium|Given IV
5812739|NCT00062231|Drug|amoxicillin-clavulanate potassium|
5812740|NCT00062231|Drug|ciprofloxacin|
5812741|NCT00062231|Drug|moxifloxacin hydrochloride|
5812742|NCT00062231|Procedure|management of therapy complications|
5812743|NCT00062205|Drug|imatinib mesylate|
5812744|NCT00062179|Drug|carboplatin|Carboplatin: dosed at an AUC of 6 by the Calvert Formula 3 cycles of carboplatin 21 days apart
5812745|NCT00062179|Drug|celecoxib|Celecoxib: 400 mg po BID celecoxib 3-7 days before first dose of chemotherapy
5812746|NCT00062179|Drug|paclitaxel|Paclitaxel: 225 mg/m2 by 3-hour intravenous infusion 3 cycles of paclitaxel 21 days apart
5812747|NCT00062179|Other|Placebo|placebo 3-7 days before first dose of chemotherapy
5812748|NCT00062140|Drug|cyclophosphamide|
5812749|NCT00062140|Procedure|allogeneic bone marrow transplantation|
5812750|NCT00062140|Procedure|peripheral blood stem cell transplantation|
5812751|NCT00062140|Radiation|radiation therapy|
5812752|NCT00062127|Drug|irinotecan hydrochloride|Given IV
5812753|NCT00062127|Drug|thalidomide|Given orally
5812754|NCT00062127|Other|pharmacological study|Correlative studies
5812755|NCT00062114|Biological|rituximab|
5812756|NCT00062114|Radiation|yttrium Y 90 ibritumomab tiuxetan|
5812757|NCT00062101|Drug|erlotinib hydrochloride|Given orally (PO)
5812758|NCT00062101|Drug|celecoxib|Given PO
5812759|NCT00062101|Other|laboratory biomarker analysis|Correlative studies
5812760|NCT00062075|Drug|romidepsin|Given IV
5812761|NCT00062062|Drug|carboplatin|
5812762|NCT00062062|Drug|gefitinib|
5812763|NCT00062062|Drug|paclitaxel|
5812764|NCT00062049|Biological|recombinant interleukin-7|
5812765|NCT00062036|Biological|aldesleukin|
5812766|NCT00062036|Biological|filgrastim|
5812767|NCT00062036|Biological|incomplete Freund's adjuvant|
5812768|NCT00062036|Biological|interleukin-2 gene|
5812769|NCT00062036|Biological|therapeutic tumor infiltrating lymphocytes|
5812770|NCT00062036|Drug|cyclophosphamide|
5812771|NCT00062036|Drug|fludarabine phosphate|
5812772|NCT00062023|Drug|Acetylsalicylic acid (Aspirin)|Patients receive oral aspirin once daily for 12 months.
5812773|NCT00062023|Drug|Sulindac|Patients receive oral sulindac twice daily for 12 months.
5812774|NCT00062023|Drug|Ursodiol|Patients receive oral ursodiol three times daily for 12 months.
5812775|NCT00062023|Other|Sulindac Placebo|Oral sulindac placebo twice daily.
5812776|NCT00062010|Biological|interferon alpha|Interferon alpha given subcutaneously, 6 million units per square meter of body surface area on days 1 and 2 of each week for 6 weeks, followed by 2 weeks of rest. Given until disease progression or unacceptable toxicity.
5812777|NCT00062010|Drug|13-cis-retinoic acid|13-cis-retinoic acid given at 1 mg/kg of body weight by mouth on days 1 and 2 of each week for 6 weeks, followed by 2 weeks of rest. Given until disease progression or unacceptable toxicity.
5812778|NCT00062010|Drug|paclitaxel|paclitaxel administered intravenously with premedication at 75 mg/m2 of body surface area on day 2 of each week for 6 weeks, followed by 2 weeks of rest. Given until disease progression or unacceptable toxicity.
5812779|NCT00061997|Dietary Supplement|inositol|
5812780|NCT00061984|Biological|pegfilgrastim|
5812781|NCT00061984|Drug|doxorubicin hydrochloride|
5812782|NCT00061984|Drug|ifosfamide|
5812783|NCT00061984|Procedure|multimodality therapy|
5812784|NCT00061958|Drug|arsenic trioxide|Given IV
5812785|NCT00061945|Drug|allopurinol|Given PO
5812786|NCT00061945|Drug|cyclophosphamide|Given IV
5812787|NCT00061945|Drug|daunorubicin hydrochloride|Given IV
5812788|NCT00061945|Drug|vincristine sulfate|Given IV
5812789|NCT00061945|Drug|dexamethasone|Given PO and as eye drops
5812790|NCT00061945|Drug|asparaginase|Given SC
5812791|NCT00061945|Biological|filgrastim|Given SC
5812792|NCT00061945|Drug|imatinib mesylate|Given PO
5812793|NCT00061945|Drug|methotrexate|Given IT, IV, and PO
5812794|NCT00061945|Drug|cytarabine|Given IV
5812795|NCT00061945|Drug|trimethoprim-sulfamethoxazole|Given PO
5812796|NCT00061945|Drug|mercaptopurine|Given PO
5812797|NCT00061945|Drug|leucovorin calcium|Given IV and PO
5812798|NCT00061945|Biological|alemtuzumab|Given SC
5812799|NCT00061945|Drug|acyclovir|Given PO
5812800|NCT00061945|Other|laboratory biomarker analysis|Correlative studies
5812801|NCT00061945|Other|pharmacological study|Correlative studies
5812802|NCT00061932|Drug|bortezomib|Given IV
5812803|NCT00061932|Drug|irinotecan|Given IV
5812804|NCT00061919|Drug|Carboplatin, etoposide & thalidomide|Carboplatin IV on day 1 and etoposide IV on day 1 and 2 and, orally Day 3. Oral thalidomide daily beginning on day 1 for up to 24 months.
5812805|NCT00061919|Drug|Carboplatin, etoposide & placebo|Carboplatin IV on day 1 and etoposide IV on day 1 and 2 and, orally Day 3. Oral placebo daily beginning on day 1 for up to 24 months.
5812806|NCT00061906|Drug|celecoxib|Treatment will be administered on an outpatient basis. Oral celecoxib will be given at the dose of 400 mg BID for total of 12 months. Patients will be advised to take this medication with food to improve absorption.
5812807|NCT00061893|Drug|celecoxib|Given orally, Celecoxib 250 mg/m2 PO BID (500mg/m2/day) from Day 1 of Cycle 1 through Day 21 of Cycle 14. The dose should be rounded off to the nearest 100 mg. If PK studies are being done, Celecoxib should be given 24 hours prior to the other drugs for Cycle 1 only. [Celecoxib may be interrupted for up to 7 days around the time of surgical procedures.] .
5812864|NCT00061698|Behavioral|Cognitive Behavior Therapy Child Only|Participants learned and applied coping skills, problem solving, cognitive restructuring strategies and built a positive core belief.
5813112|NCT00004180|Drug|rosiglitazone maleate|
5812808|NCT00061893|Drug|cyclophosphamide|Given IV, 1200 mg/m2 IV infusion over 1 hour with MESNA uroprotection, on Day 1. For children < 1 year treat with 50% doses calculated on a m2 basis. If tolerated (no delay in administration of the next cycle due to delayed count recovery or delayed resolution of other toxicities and no serious toxicities), consider increasing to 75% and then to 100% of the calculated full dose.
5812809|NCT00061893|Drug|doxorubicin hydrochloride|Given IV, Doxorubicin 75 mg/ m2 /course continuous IV infusion over 48 hours, beginning Day 1. Note: The total doxorubicin dose per cycle is 75 mg/ m2, which will be given as 37.5 mg/m2/day x 2 days. Doxorubicin may be given as a continuous infusion or brief infusion.
5812810|NCT00061893|Drug|etoposide|Given IV, Vincristine 2 mg/m2 IV push, on Day 1. Maximum dose 2 mg. For children < 1 year treat with 50% doses calculated on a m2 basis. If tolerated (no delay in administration of the next cycle due to delayed count recovery or delayed resolution of other toxicities and no serious toxicities), consider increasing to 75% and then to 100% of the calculated full dose.
5812811|NCT00061893|Drug|ifosfamide|Given IV,Ifosfamide 1800 mg/m2 /day IV infusion over 1 hour, Days 1-5 of each cycle. (9,000 mg/m2 max total dose per cycle). Prehydrate for 6 hours, 1,000 ml/m2 total volume (165 ml/m2/hour for 6 hours). For children < 1 year treat with 50% doses calculated on a m2 basis. If tolerated (no delay in administration of the next cycle due to delayed count recovery or delayed resolution of other toxicities and no serious toxicities), consider increasing to 75% and then to 100% of the calculated full dose.
5812812|NCT00061893|Drug|vinblastine sulfate|Given IV, Vinblastine 1 mg/m2/d IV push three times per week beginning Day 1 of Cycle 1 and continuing through Day 21 of Cycle 14. In weeks during which vincristine is given, hold one dose of vinblastine and administer only 2 doses of vinblastine during that week. If vinblastine is due the same day as vincristine, hold that dose of vinblastine. [Vinblastine may be interrupted for up to 7 days around the time of surgical procedures.]
5812813|NCT00061893|Drug|vincristine sulfate|Given IV, Vincristine 2 mg/m2 IV push, on Day 1. Maximum dose 2 mg. For children < 1 year treat with 50% doses calculated on a m2 basis. If tolerated (no delay in administration of the next cycle due to delayed count recovery or delayed resolution of other toxicities and no serious toxicities), consider increasing to 75% and then to 100% of the calculated full dose.
5812814|NCT00061893|Procedure|conventional surgery|Patients who respond to induction chemotherapy undergo surgery on week 13. Patients who have inadequate margins after surgery undergo radiotherapy beginning on week 15. (see Detailed Description for frequency of administration and groups evaluated)
5812815|NCT00061893|Radiation|radiation therapy|Patients with unresectable lesions undergo radiotherapy 5 days a week for approximately 6 weeks beginning on week 13. (see Detailed Description for frequency of administration and groups evaluated)
5812816|NCT00061893|Drug|MESNA|The total daily MESNA dose is equal to at least 60% of the daily cyclophosphamide or ifosfamide dose, or by continuous infusion of the 60% dose. MESNA continuous infusion should be started at the same time as the cyclophosphamide/ifosfamide and be completed no sooner than 8 hours after the end of the cyclophosphamide or ifosfamide infusion. The oral dose of MESNA is 2x the IV dose. Patients able to tolerate oral MESNA may receive the final dose by mouth at 40% of the oxazaphosphorine (cyclophosphamide or ifosfamide) dose. The dose should be given two hours earlier than the IV dose would be given. Additionally, if the patient vomits within two hours after the oral dose, the dose should be repeated or IV MESNA given.
5812817|NCT00061893|Drug|Filgrastim|G-CSF (Filgrastim) 5 micrograms/kg/day subcutaneously beginning 24 to 48 hours after the last dose of chemotherapy, and continuing until the absolute neutrophil count is 2,000/µL or greater after nadir.
5812818|NCT00061880|Drug|forodesine hydrochloride|
5812819|NCT00061867|Drug|pegylated liposomal doxorubicin hydrochloride|
5812820|NCT00061867|Procedure|hyperthermia treatment|
5812821|NCT00061854|Drug|soblidotin|
5812822|NCT00061841|Behavioral|exercise|
5812823|NCT00061815|Biological|cetuximab|400 mg/m2 IV
5812824|NCT00061815|Drug|oxaliplatin|85 mg/m2 IV
5812825|NCT00061815|Drug|leucovorin|200 mg/m2 IV
5812826|NCT00061815|Drug|5-fluorouracil|400 mg/m2 IV
5812827|NCT00061815|Drug|5-fluorouracil|600 mg/m2 IV
5812828|NCT00061815|Biological|cetuximab|250 mg/m2 IV
5812829|NCT00033462|Drug|erlotinib hydrochloride|Given orally
5812830|NCT00033462|Other|laboratory biomarker analysis|Correlative studies
5812831|NCT00010231|Dietary Supplement|calcitriol|
5812832|NCT00010231|Drug|dexamethasone|
5812833|NCT00009932|Drug|cisplatin|
5812834|NCT00009932|Drug|fenretinide|
5812835|NCT00009932|Drug|paclitaxel|
5812836|NCT00009802|Dietary Supplement|calcitriol|
5812837|NCT00009802|Drug|paclitaxel|
5812838|NCT00061802|Drug|risperidone, quetiapine|
5812839|NCT00009789|Radiation|accelerated conformational radiotherapy|
5812840|NCT00008424|Drug|irinotecan hydrochloride|
5812841|NCT00008398|Biological|sargramostim|
5812842|NCT00008398|Procedure|quality-of-life assessment|
5812843|NCT00008398|Radiation|radiation therapy|
5812844|NCT00008203|Biological|aldesleukin|
5812845|NCT00008203|Biological|recombinant interferon gamma|
5812846|NCT00008203|Drug|carboplatin|
5812847|NCT00008203|Drug|cyclophosphamide|
5812848|NCT00008203|Drug|cyclosporine|
5812849|NCT00008203|Drug|thiotepa|
5812850|NCT00008203|Procedure|autologous bone marrow transplantation|
5812851|NCT00008203|Procedure|peripheral blood stem cell transplantation|
5812852|NCT00008112|Drug|cisplatin|
5812853|NCT00008112|Procedure|hyperthermia treatment|
5812854|NCT00008112|Radiation|brachytherapy|
5812855|NCT00008112|Radiation|radiation therapy|
5812856|NCT00061789|Drug|SPECT Imaging of Nicotinic Acetylcholine Receptors in Brain|
5812857|NCT00061776|Drug|Capsaicin Dermal Patch|
5812858|NCT00061763|Drug|Deferasirox|
5812859|NCT00061750|Drug|ICL670|
5812860|NCT00061750|Drug|deferoxamine|
5812861|NCT00061711|Drug|Hormone Replacement Therapy|
5812862|NCT00061711|Drug|Cimicifuga racemosa (Black Cohosh)|
5812863|NCT00061711|Drug|Multibotanical phytoestrogen formula|
5813110|NCT00004232|Procedure|allogeneic bone marrow transplantation|
5812865|NCT00061698|Behavioral|CBT plus Parent Training|Participants learned and applied coping skills, problem solving, cognitive restructuring strategies and built a positive core belief. Parents learned skills that helped their child to apply the strategies they learned. Parents learned how to better communicate positive information that helped their child build a positive core belief. Parents learned how to use reinforcement to support healthy behavior.
5812866|NCT00061672|Drug|ABT-510 - Thrombospondin-1 Mimetic|
5812867|NCT00061659|Drug|ABT-510 - Thrombospondin-1 mimetic|
5812868|NCT00061646|Drug|ABT-510/Thrombospondin-1 mimetic|
5812869|NCT00061646|Drug|Carboplatin/Taxol|
5812870|NCT00051714|Behavioral|Family-Based Preventive Intervention|
5812871|NCT00061633|Drug|Telavancin|Telavancin 7.5 mg/kg/day IV (intravenously) for up to 14 days
5812872|NCT00061633|Drug|Vancomycin or antistaphylococcal penicillin|Vancomycin 1 Gram IV (intravenously) every 12 hrs or nafcillin 2 Grams, oxacillin 2 Grams, or (in South Africa) cloxacillin 0.5 - 1 Gram, IV (intravenously) every 6 hrs for up to 14 days.
5812873|NCT00061620|Drug|Tezacitabine (FMdC)|7.5 mg/m2 bolus infusion daily x 5
5812874|NCT00059462|Drug|Interleukin-2 SA|HAART and Bay 50-4798
5812875|NCT00059462|Drug|HAART|HAART alone
5812876|NCT00008021|Biological|filgrastim|
5812877|NCT00008021|Biological|monoclonal antibody Lym-1|
5812878|NCT00008021|Drug|cyclosporine|
5812879|NCT00008021|Drug|paclitaxel|
5812880|NCT00008021|Procedure|peripheral blood stem cell transplantation|
5812881|NCT00008021|Radiation|indium In 111 monoclonal antibody Lym-1|
5812882|NCT00008021|Radiation|yttrium Y 90 monoclonal antibody Lym-1|
5812883|NCT00006864|Biological|aldesleukin|
5812884|NCT00006484|Drug|carboplatin|
5812885|NCT00006484|Drug|paclitaxel|
5812886|NCT00006484|Drug|tirapazamine|
5812887|NCT00061594|Drug|rhuFab V2 (ranibizumab)|
5812888|NCT00061542|Drug|BETOPTIC S (betaxolol HCl)|betaxolol HC)
5812889|NCT00061542|Drug|Timolol Gel-forming Solution (TGFS)|timolol maleate 0.25% and 0.5%
5812890|NCT00061529|Drug|Brimonidine Tartrate Ophthalmic Solution|
5812891|NCT00061516|Drug|BETAXON (levobetaxolol HCl)|levobetaxolol suspension, 0.5%
5812892|NCT00061516|Drug|AZOPT (brinzolamide)|brinzolamide suspension, 1%
5812893|NCT00061503|Drug|Travoprost|
5812894|NCT00006464|Drug|7-hydroxystaurosporine|
5812895|NCT00006464|Drug|cisplatin|
5812896|NCT00006457|Drug|oltipraz|
5812897|NCT00006383|Drug|liposomal vincristine sulfate|
5812898|NCT00006377|Drug|carboplatin|
5812899|NCT00006377|Drug|doxorubicin hydrochloride|
5812900|NCT00006377|Drug|paclitaxel|
5812901|NCT00006361|Drug|semaxanib|
5812902|NCT00061581|Device|Isolex 300i Stem Cell Selection|
5812903|NCT00061568|Procedure|Peripheral blood hematopoietic progenitor cell (PBPC) transplant|Peripheral blood hematopoietic progenitor cell (PBPC) transplant
5812904|NCT00061568|Drug|Alemtuzumab|Alemtuzumab
5812905|NCT00061568|Procedure|Peripheral blood hematopoieticprogenitor cell Apherisis|Donor-Peripheral blood hematopoietic progenitor cell (PBPC) apheresis
5812906|NCT00061568|Drug|Sirolimus|Sirolimus
5812907|NCT00061490|Behavioral|Behavioral weight control and lifestyle exercise|16 weekly educational meetings vs. waitlist control
5812908|NCT00061477|Drug|Pemetrexed|
5812909|NCT00061477|Drug|Gemcitabine|
5812910|NCT00061464|Drug|pemetrexed|
5812911|NCT00061464|Drug|gemcitabine|
5812912|NCT00061451|Drug|Pemetrexed|
5812913|NCT00061451|Drug|Gemcitabine|
5812914|NCT00006349|Dietary Supplement|vitamin E|
5812915|NCT00006349|Drug|donepezil hydrochloride|
5812916|NCT00006349|Other|placebo|
5812917|NCT00006341|Other|Implant|A total of 62 patients with early oral cancer will be recruited; in addition, 22 patients requiring a partial maxillectomy and 40 requiring a partial lateral mandibulectomy will be enrolled. The mandibular defects will be reconstructed with fibula free flap surgery. Following a healing period, implants will be placed and permitted to heal unloaded for six months. Conventional dental prostheses will be fabricated and used by patients for at least 16 weeks during Phase I healing before the implants are exposed and loaded. A few weeks after Phase II surgery, the patients will receive implant-supported dental prostheses.
5812918|NCT00061438|Drug|meropenem|
5812919|NCT00061425|Drug|radiolabeled epratuzumab|
5812920|NCT00061412|Behavioral|Comprehensive program to improve reading and writing skills|
5812921|NCT00061386|Behavioral|Nutrition and physical activity program|
5812922|NCT00061321|Drug|Nevirapine and mulitvitamins|Mothers: One dose of intrapartum nevirapine by mouth (200mg) at onset of labor Infants: One dose of liquid nevirapine by mouth within 72 hours of birth (2mg/kg) Infants: Liquid multivitamins (1ml/day) week 1 through week 6 post-partum Infants (Arm 2 Only): Liquid nevirapine (5 mg/day) by mouth, from week 1 through week 6 post-partum
5812923|NCT00061308|Drug|Topotecan|
5812924|NCT00061308|Drug|Gemcitabine|
5812925|NCT00061295|Procedure|Body weight support treadmill training|
5812926|NCT00045149|Biological|aldesleukin|
5812927|NCT00045149|Biological|therapeutic tumor infiltrating lymphocytes|
5812928|NCT00019734|Biological|aldesleukin|
5812929|NCT00019734|Biological|fowlpox virus vaccine vector|
5812930|NCT00019734|Biological|vaccinia-tyrosinase vaccine|
5812931|NCT00061373|Drug|Aspirin|A single 81 mg aspirin tablet orally (or rectal suppository equivalent dose) given as soon as possible after start of standard iv tPA and consent.
5812932|NCT00061373|Drug|tinzaparin sodium|A single weight-based dose of 80 anti-Xa International Units/kilogram (IU/kg)administered by subcutaneous (SQ) injection.
5812933|NCT00061373|Drug|eptifibatide|Eptifibatide administered iv according to dose escalation group. The five dosing groups for eptifibatide are 0, 45 µg/kg bolus, 90 µg/kg bolus, 90 µg/kg bolus plus 0.25 µg/kg/min infusion for 24 hours, and 90 µg/kg bolus plus 0.5 µg/kg/min infusion for 24 hours.
5812934|NCT00061360|Drug|ATG+Rapamune+cyclosporine|ATG+Rapamune+cyclosporine
5812935|NCT00061360|Drug|ATG+cyclosporine|ATG+cyclosporine
5813111|NCT00004232|Procedure|peripheral blood stem cell transplantation|
5812936|NCT00061347|Procedure|Fiducial marker placement|Placement of fidicual markers under MRI guidance for localization of radiaiton treatment
5812937|NCT00061282|Drug|Clotrimazole|One retention enema, administered nightly
5812938|NCT00041353|Other|cytology specimen collection procedure|
5812939|NCT00041353|Procedure|comparison of screening methods|
5812940|NCT00041353|Procedure|study of high risk factors|
5812941|NCT00019175|Biological|aldesleukin|
5812942|NCT00019175|Biological|fowlpox virus vaccine vector|
5812943|NCT00019175|Biological|gp100 antigen|
5812944|NCT00002786|Biological|aldesleukin|
5812945|NCT00002786|Biological|therapeutic tumor infiltrating lymphocytes|
5812946|NCT00061269|Procedure|Videoscopic-Assisted Retroperitoneal Debridement (VARD)|
5812947|NCT00061256|Drug|Alendronate|
5812948|NCT00061256|Drug|Calcium carbonate|
5812949|NCT00061256|Drug|Vitamin D|
5812950|NCT00061243|Biological|HIV-1 DNA vaccine with protein vaccine boost|Three doses of DNA vaccination will be administered at weeks 0, 4, and 12, and 2 doses of protein vaccination at weeks 20 and 28
5812951|NCT00061230|Behavioral|biofeedback-monitored relaxation training|
5812952|NCT00061217|Device|Unrectified prosthetic socket|
5812953|NCT00061217|Device|Rectified prosthetic socket|
5812954|NCT00061178|Drug|rhuMAb VEGF (Bevacizumab)|
5812955|NCT00061165|Behavioral|School + family changes promoting healthy eating + activity|
5812956|NCT00019084|Biological|aldesleukin|
5812957|NCT00019084|Biological|mutant p53 peptide pulsed dendritic cell vaccine|
5812958|NCT00019084|Biological|ras peptide cancer vaccine|
5812959|NCT00019084|Biological|sargramostim|
5812960|NCT00019084|Biological|therapeutic autologous lymphocytes|
5812961|NCT00019084|Biological|therapeutic tumor infiltrating lymphocytes|
5812962|NCT00015821|Drug|thalidomide|Given PO
5812963|NCT00015821|Other|laboratory biomarker analysis|Correlative studies
5812964|NCT00004868|Drug|semaxanib|
5812965|NCT00003408|Biological|aldesleukin|
5812966|NCT00003408|Biological|recombinant interferon alfa|
5812967|NCT00003408|Biological|sargramostim|
5812968|NCT00061152|Drug|Capsaicin Dermal Patch|
5812969|NCT00061139|Behavioral|Pediatric Constraint-Induced Movement therapy|
5812970|NCT00061139|Behavioral|Conventional pediatric motor rehabilitation therapy|
5812971|NCT00061126|Drug|ABX-EGF|
5812972|NCT00061113|Drug|Fluoxetine + outpatient cognitive behavioral therapy|single fixed morning dose 20 mg X 15 weeks
5812973|NCT00061113|Drug|fluoxetine|20mg, QD x 16 weeks
5812974|NCT00061113|Drug|placebo + CBT|single fixed morning dose X 16 weeks
5812975|NCT00061100|Behavioral|Behavior Therapy-RISE|manually-guided HIV intervention RISE: Reduce high risk Intravenous drug use and unsafe Sexual Encounter
5812976|NCT00061100|Behavioral|Standard prevention Education|standard psychosocial Education for HIV/hepatitis prevention
5812977|NCT00061087|Drug|Methylphenidate|Methylphenidate 80mg/day
5812978|NCT00061087|Drug|Bupropion|Bupropion 400mg/day
5812979|NCT00061087|Other|Placebo|Placebo
5812980|NCT00061074|Drug|Nicotrol|
5812981|NCT00061061|Behavioral|Behavior Therapy|
5812982|NCT00061035|Biological|Transgenic Lymphocyte Immunization Vaccine (TLI)|
5812983|NCT00006243|Biological|tyrosinase peptide|Given SC
5812984|NCT00006243|Biological|MART-1:27-35 peptide vaccine|Given SC
5812985|NCT00006243|Biological|gp100 antigen|Given SC
5812986|NCT00006243|Biological|incomplete Freund's adjuvant|Given SC
5812987|NCT00006243|Biological|sargramostim|Given SC
5812988|NCT00006243|Other|laboratory biomarker analysis|Correlative studies
5812989|NCT00006242|Drug|BMS-214662|Given IV
5812990|NCT00006242|Other|laboratory biomarker analysis|Correlative studies
5812991|NCT00006242|Other|pharmacological study|Correlative studies
5812992|NCT00006095|Drug|irinotecan hydrochloride|
5812993|NCT00006095|Drug|vincristine sulfate|
5812994|NCT00006086|Drug|BMS-188797|
5812995|NCT00006086|Drug|carboplatin|
5812996|NCT00006082|Drug|rubitecan|
5812997|NCT00061048|Biological|Alemtuzumab|Infusion of Campath-1H 3 mg on day # 1, 10 mg on day #2, and 30 mg day # 3 followed by maintenance Campath-1H 30 mg intravenously three times per week. Patients are eligible to receive a maximum of 12 weeks of maintenance Campath-1H treatment.
5812998|NCT00061022|Drug|NXY-059|
5812999|NCT00006046|Biological|monoclonal antibody Hu3S193|
5813000|NCT00005999|Drug|arsenic trioxide|
5813001|NCT00005977|Biological|filgrastim|Given IV
5813002|NCT00005977|Drug|cyclophosphamide|Given IV
5813003|NCT00005977|Drug|cytarabine|Given IV
5813004|NCT00005977|Drug|dexamethasone|Given IV
5813005|NCT00005977|Drug|doxorubicin hydrochloride|Given IV
5813006|NCT00005977|Drug|etoposide|Given IV
5813007|NCT00005977|Drug|ifosfamide|Given IV
5813008|NCT00005977|Drug|leucovorin calcium|Given IV
5813009|NCT00005977|Drug|methotrexate|Given IV
5813010|NCT00005977|Drug|vincristine sulfate|Given IV
5813011|NCT00005971|Drug|alvocidib|
5813012|NCT00005956|Biological|HER-2/neu intracellular domain protein|
5813013|NCT00005956|Biological|therapeutic autologous dendritic cells|
5813014|NCT00005868|Drug|cisplatin|
5813015|NCT00005868|Drug|docetaxel|
5813016|NCT00060996|Drug|Remodulin® (treprostinil sodium) Injection|
5813017|NCT00005813|Biological|bispecific antibody MDX447|
5813018|NCT00005813|Biological|lymphokine-activated killer cells|
5813019|NCT00005813|Procedure|conventional surgery|
5813020|NCT00060983|Procedure|Body weight supported locomotor training|
5813021|NCT00060983|Procedure|Functional electrical stimulation|
5813022|NCT00060970|Procedure|Physical Therapy|
5813023|NCT00060957|Drug|Botulinum toxin type A|
5813024|NCT00060944|Drug|Yondelis|1.5 mg/m2 administered as a 24-hour i.v. infusion on Day 1 of every 21-day treatment cycle.
5813025|NCT00060944|Drug|Yondelis|0.58 mg/m2 administered as a 3-hour i.v. infusion on Days 1, 8, and 15 of each 28-day treatment cycle.
5813026|NCT00060944|Drug|Dexamethasone|Pretreatment with 10 mg of dexamethasone i.v. 30 minutes prior to each Yondelis infusion on Days 1, 8, and 15 of each 28-day treatment cycle.
5813027|NCT00060944|Drug|Dexamethasone|Pretreatment with 20 mg of dexamethasone i.v. on Day 1 of each 21- day treatment cycle, 30 minutes prior to each Yondelis infusion.
5813028|NCT00005861|Drug|pegylated liposomal doxorubicin hydrochloride|
5813029|NCT00005588|Radiation|radiation therapy|
5813030|NCT00005587|Radiation|radiation therapy|
5813031|NCT00003203|Biological|filgrastim|Given IV
5813032|NCT00003203|Drug|carboplatin|Given IV
5813033|NCT00003203|Drug|cisplatin|Given IV
5813034|NCT00003203|Drug|cyclophosphamide|Given IV
5813035|NCT00003203|Drug|vincristine sulfate|Given IV
5813036|NCT00003203|Procedure|adjuvant therapy|
5813037|NCT00003203|Radiation|radiation therapy|1.8 Gy/fx x 20fx=36Gy Craniospinal XRT*
5813038|NCT00060931|Drug|carvedilol|
5813039|NCT00060931|Drug|metoprolol|
5813040|NCT00060918|Drug|carvedilol|
5813041|NCT00060918|Drug|metoprolol|
5813042|NCT00060905|Drug|Divalproex Sodium (Depakote ER)|
5813043|NCT00060892|Genetic|HGF plasmid|Intramuscular injections into index leg on Days 0, 14, and 28
5813044|NCT00005086|Drug|cisplatin|
5813045|NCT00005086|Drug|docetaxel|
5813046|NCT00005086|Drug|gemcitabine hydrochloride|
5813047|NCT00005086|Drug|methotrexate|
5813048|NCT00005078|Drug|carboplatin|
5813049|NCT00005078|Drug|paclitaxel|
5813050|NCT00005078|Drug|tirapazamine|
5813051|NCT00060866|Drug|Propranolol|
5813052|NCT00060840|Drug|Nitric Oxide|40 ppm of Nitric Oxide continuously administered for 48 hours
5813053|NCT00060840|Drug|Nitrogen|Nitrogen (N2) administered at 40 ppm for 48 hours
5813054|NCT00060827|Device|Head Impact Recording Technology (HIRT)|
5813055|NCT00060814|Other|Combined intervention|300 mg bupropion plus 4mg nicotine gum ad lib plus motivational interviewing counseling
5813056|NCT00060801|Drug|BIIL 283 BS (Amelubent)|
5813057|NCT00004931|Drug|leucovorin calcium|Given IV
5813058|NCT00004931|Drug|fluorouracil|Given IV
5813059|NCT00004931|Drug|oxaliplatin|Given IV
5813060|NCT00004931|Other|laboratory biomarker analysis|Correlative studies
5813061|NCT00004928|Dietary Supplement|calcitriol|
5813062|NCT00004928|Drug|zoledronic acid|
5813063|NCT00004925|Biological|trastuzumab|
5813064|NCT00004925|Drug|pegylated liposomal doxorubicin hydrochloride|
5813065|NCT00004916|Drug|ifosfamide|
5813066|NCT00004916|Drug|paclitaxel|
5813067|NCT00004916|Drug|teniposide|
5813068|NCT00004916|Procedure|peripheral blood stem cell transplantation|
5813069|NCT00004911|Procedure|bowel obstruction management|
5813070|NCT00004911|Procedure|quality-of-life assessment|
5813071|NCT00060762|Behavioral|Interpersonal Therapy|20 sessions of interpersonal therapy were provided over a 6-month period
5813072|NCT00060762|Behavioral|Behavioral Weight Loss Treatment|20 sessions of behavioral weight loss treatment were provided over a 6-month period
5813073|NCT00060762|Behavioral|Guided Self Help|10 sessions of guided self help were provided over a 6-month period
5813074|NCT00060710|Drug|CP-461|
5813075|NCT00060749|Drug|Docosahexaenoic Acid (DHA) Dietary Supplement|
5813076|NCT00060697|Behavioral|Adolescent sexual activity education for mothers|
5813077|NCT00060684|Drug|Pixantrone (BBR 2778)|
5813078|NCT00060684|Drug|fludarabine|
5813079|NCT00060684|Drug|dexamethasone|
5813080|NCT00060684|Drug|rituximab|
5813081|NCT00060671|Drug|rituximab|
5813082|NCT00060671|Drug|Pixantrone (BBR 2778)|
5813083|NCT00060645|Drug|ridaforolimus|There are sequential dosage cohorts ranging from 3 mg - 225 mg per dose. AP23573 is given intravenously over 30 minutes, administered once daily for 5 days every 2 weeks.
5813084|NCT00060632|Drug|ridaforolimus|"Administered intravenously once weekly for 4 weeks (1 cycle).~In the absence of disease progression or unacceptable toxicity, patients could continue to receive additional cycles."
5813085|NCT00060619|Behavioral|thermal biofeedback|
5813086|NCT00060619|Behavioral|relaxation training|
5813087|NCT00060619|Behavioral|cognitive coping skills|
5813088|NCT00060619|Behavioral|parent education|
5813089|NCT00060606|Procedure|Prenatal Myelomeningocele Repair Surgery|Fetal surgery to repair spina bifida defect performed prior to 26 weeks of gestation with delivery by C-section at approximately 37 weeks of gestation.
5813090|NCT00060606|Procedure|Postnatal Myelomeningocele Repair Surgery|Standard postnatal surgical closure of the spina bifida defect
5813091|NCT00060567|Drug|E7070 + irinotecan combination|Escalating doses starting from 125 mg/m2 irinotecan plus 250 mg/m2 E7070 combination.
5813092|NCT00060567|Drug|Irinotecan + E7070 combination|Escalating doses starting from 100 mg/m2 irinotecan plus 400 mg/m2 E7070 combination.
5813093|NCT00060567|Drug|Irinotecan + E7070 combination|Escalating doses starting from 100 mg/m2 irinotecan plus 400 mg/m2 E7070 combination.
5813094|NCT00004910|Procedure|bowel obstruction management|
5813095|NCT00004910|Procedure|quality-of-life assessment|
5813096|NCT00004895|Drug|octreotide acetate|
5813097|NCT00004255|Biological|anti-thymocyte globulin|
5813098|NCT00004255|Biological|filgrastim|
5813099|NCT00004255|Drug|cyclophosphamide|
5813100|NCT00004255|Drug|fludarabine phosphate|
5813101|NCT00004255|Drug|methylprednisolone|
5813102|NCT00004255|Drug|tacrolimus|
5813103|NCT00004255|Procedure|allogeneic bone marrow transplantation|
5813104|NCT00004255|Procedure|in vitro-treated bone marrow transplantation|
5813105|NCT00004255|Radiation|radiation therapy|
5813106|NCT00004232|Biological|filgrastim|
5813107|NCT00004232|Drug|cyclosporine|
5813108|NCT00004232|Drug|methylprednisolone|
5813109|NCT00004232|Drug|prednisone|
5813113|NCT00060580|Procedure|Raman scattering spectroscopy|
5813114|NCT00060554|Drug|fondaparinux sodium|
5813115|NCT00060554|Drug|heparin|
5813116|NCT00060554|Procedure|percutaneous coronary intervention (PCI)|
5813117|NCT00060515|Drug|RG2133 (2',3',5'-tri-O-acetyluridine)|
5813118|NCT00060502|Drug|Infliximab; Gemcitabine|
5813119|NCT00060489|Drug|SEROQUEL (quetiapine fumarate) Tablets|
5813120|NCT00004094|Drug|carboplatin|
5813121|NCT00004094|Drug|fluorouracil|
5813122|NCT00004094|Drug|hydroxyurea|
5813123|NCT00004094|Drug|paclitaxel|
5813124|NCT00004094|Procedure|conventional surgery|
5813125|NCT00004094|Radiation|radiation therapy|
5813126|NCT00004068|Drug|irinotecan hydrochloride|
5813127|NCT00004068|Drug|temozolomide|
5813128|NCT00004068|Procedure|conventional surgery|
5813129|NCT00004068|Radiation|radiation therapy|
5813130|NCT00004059|Drug|7-hydroxystaurosporine|
5813131|NCT00004059|Drug|fluorouracil|
5813132|NCT00004052|Biological|QS21|
5813133|NCT00004052|Biological|bcr-abl peptide vaccine|
5813134|NCT00004008|Drug|bryostatin 1|
5813135|NCT00060528|Drug|Recombinant Fowlpox-GM-CSF|
5813136|NCT00060528|Drug|Recombinant Fowlpox-PSA (L155)-TRICOM (PROSTVAC-F/TRICOM)|
5813137|NCT00060528|Drug|Recombinant Vaccinia-PSA (L155)-TRICOM (PROSTVAC-V/TRICOM)|
5813138|NCT00060528|Drug|Recombinant Human GM-CSF|
5813139|NCT00060476|Drug|rofecoxib|
5813140|NCT00060476|Drug|Comparator: placebo (unspecified)|
5813141|NCT00060463|Behavioral|Increased access to emergency contraceptive pills|
5813142|NCT00060450|Drug|nitric oxide for inhalation|Either 10 or 20 ppm of inhaled nitric oxide for 24 hour post transplant
5813143|NCT00060450|Drug|Placebo|Placebo gas will be given at 10 or 20 ppm for 24 hours post transplant
5813144|NCT00060437|Drug|perifosine|
5813145|NCT00060424|Drug|Cyclosporine|Given PO
5813146|NCT00060424|Drug|Fludarabine Phosphate|Given IV
5813147|NCT00060424|Procedure|Hematopoietic Cell Transplantation|Undergo allogeneic peripheral blood stem cell transplant
5813148|NCT00060424|Other|Laboratory Biomarker Analysis|Correlative studies
5813149|NCT00060424|Drug|Mycophenolate Mofetil|Given PO
5813150|NCT00060424|Procedure|Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|Undergo allogeneic peripheral blood stem cell transplant
5813151|NCT00060424|Radiation|Total-Body Irradiation|Undergo TBI
5813152|NCT00060411|Drug|erlotinib hydrochloride|Given IV
5813153|NCT00060411|Drug|fluorouracil|Given IV
5813154|NCT00060411|Drug|leucovorin calcium|Given IV
5813155|NCT00060411|Drug|oxaliplatin|Given IV
5813156|NCT00060411|Biological|bevacizumab|Given IV
5813157|NCT00060398|Biological|epoetin alfa|
5813158|NCT00060398|Drug|dexamethasone|
5813159|NCT00060385|Drug|CHOP regimen|
5813160|NCT00060385|Drug|EPOCH regimen|
5813161|NCT00060385|Drug|cyclophosphamide|
5813162|NCT00060385|Drug|doxorubicin hydrochloride|
5813163|NCT00060385|Drug|etoposide|
5813164|NCT00060385|Drug|prednisone|
5813165|NCT00060385|Drug|vincristine sulfate|
5813166|NCT00060385|Radiation|radiation therapy|
5813167|NCT00060372|Drug|ipilimumab|Given IV
5813168|NCT00060372|Drug|therapeutic allogeneic lymphocytes|Given IV
5813169|NCT00060359|Drug|Carboplatin|Given IV
5813170|NCT00060359|Drug|Paclitaxel Poliglumex|Given IV
5813171|NCT00060359|Other|Pharmacological Study|Correlative studies
5813172|NCT00060346|Biological|rituximab|Rituximab is given intravenously. The initial rate is 50 mg/hr for the 1st hour. If no toxicity, the rate may be escalated in 50 mg/hr increments at 30-minute intervals to a maximum of 400 mg/hr. If the first dose is well tolerated, the initial rate for subsequent dose is 100 mg/hr, increased in 100 mg/hr increments at 30-minute intervals, not to exceed 400 mg/hr. If the patient experiences fever and rigors, the antibody infusion is discontinued. The severity of the side effects should be evaluated. If the symptoms improve, the infusion is continued initially at half the previous rate. Following the antibody infusion, the intravenous line should be maintained for medications as needed. If there are no complications after one hour of observation, the intravenous line may be discontinued.
5813173|NCT00060346|Drug|cyclophosphamide|"Cyclophosphamide will be given at a dosage of 750 mg/m² intravenously on day 1 of each cycle (1 cycle =21 days) for 6 cycles. Dose is based on surface area calculated based on actual body weight.~The drug should be administered as a rapid IV infusion over 5 to 30 minutes."
5813174|NCT00060346|Drug|Doxorubicin|"Doxorubicin will be given intravenously at a dosage of 50 mg/m² on day 1 of each cycle for 6 cycles (1 cycle =21 days). Dose is based on surface area calculated based on actual body weight.~Doxorubicin should be administered as a continuous infusion into tubing of a freely flowing intravenous line for 5 -15 minutes. Avoid extravasation."
5813175|NCT00060346|Drug|Prednisone|Prednisone will be administered at 100 mg/m² orally, days 1-5 of each cycle for 6 cycles (1 cycle =21 days). Dose is based on surface area calculated based on actual body weight.
5813176|NCT00060346|Drug|Vincristine|"Vincristine will be administered 1.4 mg/m² intravenously (Maximum dose = 2.0 mg) on day 1 of each cycle for 6 cycles (1 cycle =21 days). Dose is based on surface area calculated based on actual body weight.~Given as IV push over 1 minute, using extravasation precautions."
5813177|NCT00060333|Radiation|radiation therapy|
5813178|NCT00060320|Dietary Supplement|black cohosh|
5813179|NCT00060320|Other|placebo|
5813180|NCT00060307|Drug|erlotinib hydrochloride|Given orally
5813181|NCT00060307|Other|laboratory biomarker analysis|Correlative studies
5813182|NCT00060294|Biological|rituximab|
5813183|NCT00060294|Radiation|yttrium Y 90 ibritumomab tiuxetan|
5813184|NCT00060268|Drug|HPPH|iv
5813185|NCT00060255|Drug|busulfan|iv
5813186|NCT00060255|Drug|carboplatin|iv
5813187|NCT00060255|Drug|carmustine|iv
5813188|NCT00060255|Drug|cyclophosphamide|iv
5813189|NCT00060255|Drug|etoposide|iv
5813190|NCT00060255|Drug|melphalan|oral
5813192|NCT00060255|Procedure|autologous bone marrow transplantation|iv
5813193|NCT00060255|Procedure|bone marrow ablation with stem cell support|iv
5813194|NCT00060255|Procedure|peripheral blood stem cell transplantation|iv
5813195|NCT00060255|Radiation|radiation therapy|body x-ray
5813196|NCT00060242|Drug|fosbretabulin disodium|Combretastatin A4 phosphate IV over 10 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients achieving a complete response (CR) receive 2 courses beyond documentation of the CR.
5813197|NCT00060203|Drug|brostallicin|"Patients receive brostallicin IV over 10-30 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.~Cohorts of 3-6 patients receive escalating doses of brostallicin until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which at least 2 of 6 patients experience dose-limiting toxicity."
5813198|NCT00060151|Drug|pazopanib hydrochloride|
5813199|NCT00060138|Biological|monoclonal antibody CAL|
5813200|NCT00060138|Drug|zoledronic acid|
5813201|NCT00060125|Drug|tipifarnib|Given orally
5813202|NCT00060125|Other|laboratory biomarker analysis|Correlative studies
5813203|NCT00060112|Biological|oblimersen sodium|Given IV
5813204|NCT00060112|Drug|gemcitabine hydrochloride|Given IV
5813205|NCT00060112|Other|pharmacological study|Correlative studies
5813206|NCT00060112|Other|laboratory biomarker analysis|Correlative studies
5813207|NCT00060099|Biological|HspE7|
5813208|NCT00060086|Dietary Supplement|pomegranate juice|Subjects receive oral pomegranate juice once daily. Treatment continues for 18 months in the absence of disease progression or unacceptable toxicity.
5813209|NCT00060021|Procedure|acupuncture therapy|
5813210|NCT00060021|Procedure|management of therapy complications|
5813211|NCT00060021|Procedure|pain therapy|
5813212|NCT00060008|Radiation|fludeoxyglucose F 18|
5813213|NCT00060008|Radiation|gadopentetate dimeglumine|
5813214|NCT00059995|Biological|iratumumab|
5813215|NCT00059982|Drug|perifosine|
5813216|NCT00059943|Drug|docetaxel|
5813217|NCT00059930|Drug|FOLFOX regimen|
5813218|NCT00059930|Drug|dexamethasone|
5813219|NCT00059930|Drug|floxuridine|
5813220|NCT00059930|Drug|fluorouracil|
5813221|NCT00059930|Drug|leucovorin calcium|
5813222|NCT00059930|Drug|oxaliplatin|
5813223|NCT00059930|Procedure|adjuvant therapy|
5813224|NCT00059930|Procedure|conventional surgery|
5813225|NCT00059917|Drug|polyglutamate camptothecin|
5813226|NCT00059904|Biological|aldesleukin|
5813227|NCT00059904|Biological|rituximab|
5813228|NCT00059891|Procedure|conventional surgery|
5813229|NCT00059891|Procedure|management of therapy complications|
5813230|NCT00059878|Biological|recombinant interferon gamma|
5813231|NCT00059878|Drug|voriconazole|
5813232|NCT00059865|Drug|gemcitabine hydrochloride|
5813233|NCT00059865|Drug|pemetrexed disodium|
5813234|NCT00059852|Drug|erlotinib hydrochloride|
5813235|NCT00059852|Drug|gemcitabine hydrochloride|
5813236|NCT00059839|Drug|doxorubicin hydrochloride|Given IV
5813237|NCT00059839|Drug|mercaptopurine|Given by mouth
5813238|NCT00059839|Drug|methotrexate|Given IV and intrathecally
5813239|NCT00059839|Drug|prednisone|Given by mouth
5813240|NCT00059839|Drug|vinblastine sulfate|Given IV
5813241|NCT00059839|Drug|vincristine sulfate|Given IV
5813242|NCT00059826|Biological|interferon-alfa-2b|IV
5813243|NCT00059826|Drug|cisplatin|IV
5813244|NCT00059826|Drug|5-fluorouracil|IV
5813245|NCT00059826|Radiation|radiation therapy|
5813246|NCT00059813|Biological|recombinant interferon alfa|Given SC
5813247|NCT00059813|Biological|oblimersen sodium|Given IV
5813248|NCT00059813|Other|pharmacological study|Correlative studies
5813249|NCT00059800|Radiation|boron neutron capture therapy|
5813250|NCT00059787|Drug|paclitaxel|Given IV
5813251|NCT00059787|Drug|carboplatin|Given IV
5813252|NCT00059787|Drug|erlotinib|Given PO
5813253|NCT00059761|Drug|cisplatin|
5813254|NCT00059761|Drug|irinotecan hydrochloride|
5813255|NCT00059761|Radiation|radiation therapy|
5813256|NCT00059735|Drug|E7070|
5813257|NCT00043108|Drug|carboplatin|
5813258|NCT00043108|Drug|paclitaxel|
5813259|NCT00043108|Procedure|conventional surgery|
5813260|NCT00043108|Radiation|radiation therapy|
5813261|NCT00030667|Drug|imatinib mesylate|Given orally
5813262|NCT00030667|Other|laboratory biomarker analysis|Correlative studies
5813263|NCT00030667|Other|pharmacological study|Correlative studies
5813264|NCT00030524|Drug|gefitinib|
5813265|NCT00027599|Biological|bevacizumab|
5813266|NCT00027599|Biological|prostatic acid phosphatase-sargramostim fusion protein|
5813267|NCT00027599|Biological|sipuleucel-T|
5813268|NCT00027599|Biological|therapeutic autologous dendritic cells|
5813269|NCT00027599|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5813270|NCT00017134|Drug|fenretinide|
5813271|NCT00017134|Procedure|conventional surgery|
5813272|NCT00016315|Drug|carboplatin|
5813273|NCT00016315|Drug|gemcitabine hydrochloride|
5813274|NCT00016315|Drug|paclitaxel|
5813275|NCT00016315|Radiation|radiation therapy|
5813276|NCT00006225|Biological|filgrastim|
5813277|NCT00006225|Biological|recombinant flt3 ligand|
5813278|NCT00006225|Biological|recombinant human thrombopoietin|
5813279|NCT00006225|Biological|recombinant interleukin-3|
5813280|NCT00006225|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5813281|NCT00005793|Drug|Cytarabine|
5813282|NCT00005793|Drug|Daunorubicin|
5813283|NCT00005793|Drug|Etoposide|
5813284|NCT00005793|Drug|Topotecan|
5813285|NCT00005065|Drug|paclitaxel|Given IV
5813286|NCT00005065|Drug|carboplatin|Given IV
5813287|NCT00005065|Drug|motexafin gadolinium|Given IV
5813288|NCT00005065|Procedure|conventional surgery|Undergo complete surgical resection
5813289|NCT00005065|Radiation|radiation therapy|Undergo radiation therapy
5813290|NCT00004127|Drug|FOLFOX regimen|
5813291|NCT00004127|Drug|fluorouracil|
5813292|NCT00004127|Drug|leucovorin calcium|
5813293|NCT00004127|Drug|oxaliplatin|
5813294|NCT00004095|Drug|gemcitabine hydrochloride|
5813295|NCT00004095|Drug|irinotecan hydrochloride|
5813296|NCT00019435|Biological|LMB-9 immunotoxin|
5813297|NCT00002765|Biological|LMB-2 immunotoxin|
5813298|NCT00059722|Drug|ZD6474|
5813299|NCT00059722|Drug|Placebo|
5813300|NCT00059722|Drug|ZD1839|
5813301|NCT00059709|Procedure|Mediated Negotiation Training|
5813302|NCT00059696|Procedure|Constraint-Induced Movement Therapy|
5813303|NCT00059683|Procedure|cervical cerclage|Cerclage is a circumferential stitch of non-absorbable suture placed around the cervix
5813304|NCT00018941|Biological|aldesleukin|
5813305|NCT00005837|Drug|oxaliplatin|
5813306|NCT00005818|Drug|irinotecan hydrochloride|Given IV
5813307|NCT00005818|Drug|semaxanib|Given IV
5813308|NCT00005818|Other|laboratory biomarker analysis|Correlative studies
5813309|NCT00005025|Biological|herpes simplex thymidine kinase|
5813310|NCT00005025|Drug|ganciclovir|
5813311|NCT00002971|Drug|O6-benzylguanine|
5813312|NCT00059670|Procedure|Shaker Exercise vs. Traditional Dysphagia Therapy Regime|
5813313|NCT00059657|Drug|Ecraprost in lipid emulsion|
5813314|NCT00059644|Drug|Ecraprost in lipid emulsion|
5813315|NCT00003933|Other|laboratory biomarker analysis|
5813316|NCT00003926|Drug|amifostine trihydrate|"Patients receive amifostine intravenous (IV) over 5 minutes beginning 30 minutes prior to melphalan and thiotepa administration on days -5 to -1.~Cohorts of 3-6 patients receive escalating doses of amifostine until the maximum tolerated dose is determined."
5813317|NCT00003926|Drug|busulfan|Patients receive oral busulfan every 6 hours on days -8 to -6.
5813318|NCT00003926|Drug|filgrastim|All patients receive filgrastim (G-CSF) IV for 1 week.
5813319|NCT00003926|Drug|melphalan|melphalan intravenous (IV) over 30 minutes on days -5 and -4
5813320|NCT00003926|Drug|thiotepa|thiotepa intravenous (IV) over 2 hours on days -3 and -2.
5813321|NCT00003926|Procedure|peripheral blood stem cell transplantation (PBSC)|PBSC are reinfused on day 0
5813322|NCT00003925|Drug|gemcitabine hydrochloride|
5813323|NCT00003925|Drug|leucovorin calcium|
5813324|NCT00003925|Drug|tegafur-uracil|
5813325|NCT00003802|Drug|pyrazoloacridine|
5813326|NCT00003797|Biological|trastuzumab|
5813327|NCT00003797|Drug|gemcitabine hydrochloride|
5813328|NCT00059631|Drug|Mitoxantrone (Novantrone)|Starting dose of 3 mg/m^2, four weekly intravenous injections (on Days 1, 8, 15 and 22) over eight 5 week cycles.
5813329|NCT00059631|Drug|Bortezomib (PS-341)|Starting Dose of 1.4 mg/m^2, four weekly intravenous injections (on Days 1, 8, 15, and 22) over eight 5 week cycles.
5813330|NCT00059618|Drug|PS-341 (Bortezomib)|Starting dose 0.8 mg/m^2 given by vein over 5-10 seconds Day 1, 4, 8 and 11 of 28 day cycle for 8 cycles.
5813331|NCT00059618|Drug|Carboplatin|AUC 5 by vein administered over one hour Day 1 of 28 day cycle for 8 cycles.
5813332|NCT00059605|Genetic|DOTAP:Chol-fus1|Infusion of DOTAP:Chol-fus1 by vein once every 3 weeks.
5813333|NCT00059592|Drug|Valacyclovir|
5813334|NCT00003757|Biological|rituximab|
5813335|NCT00003649|Biological|Ad5CMV-p53 gene|
5813336|NCT00003627|Drug|cisplatin|
5813337|NCT00003627|Drug|fluorouracil|
5813338|NCT00003627|Radiation|radiation therapy|
5813339|NCT00003484|Drug|carmustine|
5813340|NCT00003484|Drug|irinotecan hydrochloride|
5813341|NCT00003484|Procedure|surgical procedure|
5813342|NCT00003484|Radiation|iodine I 131 monoclonal antibody 81C6|
5813343|NCT00003436|Drug|amsacrine|
5813344|NCT00003436|Drug|asparaginase|
5813345|NCT00003436|Drug|cytarabine|
5813346|NCT00003436|Drug|daunorubicin hydrochloride|
5813347|NCT00003436|Drug|etoposide|
5813348|NCT00003436|Drug|methotrexate|
5813349|NCT00003436|Drug|mitoxantrone hydrochloride|
5813350|NCT00003436|Drug|therapeutic hydrocortisone|
5813351|NCT00003436|Procedure|allogeneic bone marrow transplantation|
5813352|NCT00059553|Behavioral|Locomotor treadmill training with body weight support|
5813353|NCT00059527|Behavioral|Healthy Youth Places: a behavior change model|
5813354|NCT00059514|Behavioral|Modified Project Toward No Tobacco Use|
5813355|NCT00005836|Drug|oxaliplatin|
5813356|NCT00059475|Drug|Glycoprotein 100 (GP100): 209-217 (210M)|
5813357|NCT00059475|Drug|Interleukin-2 (IL-2)|720,000 IU/kg as an intravenous bolus over a 15 minute period every 8 hours and continuing for up to 4 days (a maximum of 12 doses).
5813358|NCT00059475|Drug|Montanide ISA 51|
5813359|NCT00059475|Drug|Melanoma antigen recognized by T-cells (MART)-1: 27-35|
5813360|NCT00059475|Drug|27-35 (27L): melanoma antigen recognized by T-cells (MART)-1|
5813361|NCT00059475|Drug|melanoma antigen recognized by T-cells (MART)-1: 26-35(27L)|
5813362|NCT00059436|Behavioral|Mental effort in muscle strengthening|
5813363|NCT00003432|Biological|carcinoembryonic antigen RNA-pulsed DC cancer vaccine|Approximately 60-90 days after the peripheral blood stem cell transplant, patients receive CEA RNA pulsed dendritic cells IV every 3 weeks for a total of 4 doses.
5813364|NCT00003346|Drug|acetaminophen|
5813365|NCT00003346|Drug|acetylcysteine|
5813366|NCT00003346|Drug|carmustine|
5813367|NCT00003341|Biological|epoetin alfa|
5813368|NCT00003341|Procedure|quality-of-life assessment|
5813369|NCT00003324|Procedure|conventional surgery|
5813370|NCT00003324|Radiation|radiation therapy|
5813371|NCT00003311|Biological|filgrastim|
5813372|NCT00003311|Drug|cyclophosphamide|
5813375|NCT00003311|Drug|doxorubicin hydrochloride|
5813376|NCT00003311|Drug|methotrexate|
5813377|NCT00003311|Drug|vincristine sulfate|
5813378|NCT00059384|Behavioral|Concentration-controlled therapy|
5813379|NCT00059371|Procedure|male circumcision|
5813380|NCT00059358|Drug|Ribavirin plus interferon alfa-2b|Oral tablets taken daily
5813381|NCT00059358|Drug|Ribavirin|Oral tablet taken daily
5813382|NCT00059358|Drug|Peginterferon alfa-2b|Subcutaneous injection
5813383|NCT00059345|Procedure|Acupuncture|Electroacupuncture treatments provided two times per week for 6 weeks
5813384|NCT00059345|Procedure|Placebo acupuncture|Placebo acupuncture treatments provided 2 times per week for 6 weeks
5813385|NCT00059345|Other|Usual Care|Usual care for knee osteoarthritis
5813386|NCT00059332|Drug|Magnesium Sulfate|Paramedics initiate a loading dose of 4 grams magnesium sulfate IV over 15 minutes, followed after hospital arrival by a maintenance infusion of 16 grams magnesium sulfate IV over 24 hours.
5813387|NCT00059332|Drug|Normal Saline|Paramedics initiate a loading dose of placebo normal saline IV over 15 minutes, followed after hospital arrival by a maintenance infusion of placebo normal saline IV over 24 hours.
5813388|NCT00059319|Procedure|single aorta clamp with retrograde cardioplegia|
5813389|NCT00059319|Procedure|multiple aorta clamps with antegrade cardioplegia|
5813390|NCT00059306|Drug|aspirin|Participants receive aspirin + placebo, specifically: aspirin (325 mg) with placebo (an inactive substance). Participants will take 1 of each pill a day until the end of the study.
5813391|NCT00059306|Drug|clopidogrel|Participants will receive aspirin + clopidogrel, specifically: aspirin (325 mg) with clopidogrel (75 mg)-- Participants will take 1 of each pill a day until the end of the study.
5813392|NCT00059306|Other|Target of Blood Pressure|Participants will be assigned to one of 2 groups of blood pressure control. The difference between the two groups is the target level of systolic blood pressure—either 130-149 mmHg or below 130 mmHg; to do so, the scientists will use medications that are already in the market for blood pressure management.
5813393|NCT00059306|Other|placebo|an inactive substance
5813394|NCT00058981|Drug|DiaPep277|
5813395|NCT00059280|Biological|Myozyme|20 mg/kg qow or 40mg/kg qow
5813396|NCT00059267|Drug|HBIG, Epivir, Hepsera|
5813397|NCT00059254|Dietary Supplement|Oleic acid (OA)|OA-enriched (HI OA; fat, 40%; PA, 1.7%; OA, 31.4%)
5813398|NCT00059254|Dietary Supplement|Palmitic Acid (PA)|PA-enriched (HI PA; fat, 40% of energy; PA, 16.8%; OA, 16.4%)
5813399|NCT00059241|Behavioral|Parent-child communication education|
5813400|NCT00059241|Behavioral|Service learning|
5813401|NCT00059241|Behavioral|Classroom health curriculum|
5813402|NCT00059215|Drug|Prasugrel (CS-747)|Administered orally
5813403|NCT00059215|Drug|Clopidogrel|Administered orally
5813404|NCT00003290|Biological|gonadotrophin releasing hormone|
5813405|NCT00003290|Radiation|radiation therapy|
5813406|NCT00003262|Biological|bleomycin sulfate|
5813407|NCT00003262|Biological|filgrastim|
5813408|NCT00003262|Drug|Stanford V regimen|
5813409|NCT00003262|Drug|doxorubicin hydrochloride|
5813410|NCT00003262|Drug|epirubicin hydrochloride|
5813411|NCT00003262|Drug|etoposide|
5813412|NCT00003262|Drug|mechlorethamine hydrochloride|
5813413|NCT00003262|Drug|prednisone|
5813414|NCT00003262|Drug|vinblastine sulfate|
5813415|NCT00003262|Drug|vincristine sulfate|
5813416|NCT00003205|Drug|bryostatin 1|
5813417|NCT00003193|Drug|amifostine trihydrate|
5813418|NCT00003193|Drug|paclitaxel|
5813419|NCT00003193|Procedure|conventional surgery|
5813420|NCT00003193|Radiation|radiation therapy|
5813421|NCT00003173|Biological|filgrastim|
5813422|NCT00003173|Drug|thiotepa|
5813423|NCT00003173|Procedure|autologous bone marrow transplantation|
5813424|NCT00003173|Procedure|peripheral blood stem cell transplantation|
5813425|NCT00059228|Drug|17beta Estradiol|Alora 100 microgram per day by skin patch for 6 weeks.
5813426|NCT00059228|Drug|Placebos|Placebo skin patch for 6 weeks
5813427|NCT00059202|Drug|Ursodeoxycholic Acid|
5813428|NCT00059189|Device|Magstim Rapid Magnetic Stimulator|
5813429|NCT00005839|Drug|capecitabine|
5813430|NCT00005839|Drug|oxaliplatin|
5813431|NCT00004220|Drug|gemcitabine hydrochloride|
5813432|NCT00004220|Drug|oxaliplatin|
5813433|NCT00004257|Drug|fluorouracil|
5813434|NCT00004257|Drug|oxaliplatin|
5813435|NCT00004257|Procedure|conventional surgery|
5813436|NCT00004257|Radiation|radiation therapy|
5813437|NCT00004243|Drug|docetaxel|
5813438|NCT00004243|Drug|oxaliplatin|
5813439|NCT00003597|Biological|recombinant human thrombopoietin|
5813440|NCT00003597|Drug|carboplatin|
5813441|NCT00003597|Drug|etoposide|
5813442|NCT00003597|Drug|ifosfamide|
5813443|NCT00003597|Biological|G-CSF|
5813444|NCT00003163|Biological|filgrastim|
5813445|NCT00003163|Biological|sargramostim|
5813446|NCT00003163|Drug|cyclophosphamide|
5813447|NCT00003163|Drug|melphalan|
5813448|NCT00003163|Procedure|autologous bone marrow transplantation|
5813449|NCT00003163|Procedure|peripheral blood stem cell transplantation|
5813450|NCT00003163|Radiation|radiation therapy|
5813451|NCT00003162|Procedure|pain therapy|
5813452|NCT00003162|Radiation|radiation therapy|
5813453|NCT00003129|Drug|valrubicin|
5813454|NCT00003124|Drug|flutamide|
5813455|NCT00003124|Drug|leuprolide acetate|
5813456|NCT00003124|Radiation|radiation therapy|
5813457|NCT00003064|Biological|filgrastim|
5813458|NCT00003064|Drug|carboplatin|
5813459|NCT00003064|Drug|etoposide phosphate|
5813460|NCT00003064|Drug|paclitaxel|
5813461|NCT00003064|Drug|thiotepa|
5813462|NCT00003064|Drug|topotecan hydrochloride|
5822958|NCT00002071|Drug|Epoetin alfa|
5813463|NCT00003064|Procedure|peripheral blood stem cell transplantation|
5813464|NCT00002972|Drug|paclitaxel|
5813465|NCT00058994|Drug|anecortave acetate|
5813466|NCT00058968|Drug|Duloxetine hydrochloride|
5813467|NCT00058968|Drug|placebo|
5813468|NCT00058955|Drug|sodium oxybate, triazolam and pentobarbital|sodium oxybate, triazolam and pentobarbital
5813469|NCT00058942|Device|home drinking water treatment device|
5813470|NCT00058929|Drug|treprostinil sodium|
5813471|NCT00058903|Drug|sertraline|
5813472|NCT00058890|Drug|Gabapentin|Under code, the study drug was started at 100 mg by mouth 3 times a day for 3 days, to be increased, if necessary and in the absence of side effects, by 300 mg every 3 days to a maximum of 2,400 mg daily in divided doses.
5813473|NCT00058890|Drug|Placebo|
5813474|NCT00002945|Biological|aldesleukin|IV
5813475|NCT00002945|Biological|filgrastim|IV
5813476|NCT00002945|Drug|cyclophosphamide|IV
5813477|NCT00002945|Drug|cytarabine|IV
5813478|NCT00002945|Drug|etoposide|IV
5813479|NCT00002945|Drug|idarubicin|IV
5813480|NCT00002945|Drug|melphalan|IV
5813481|NCT00002945|Procedure|peripheral blood stem cell transplantation|IV
5813482|NCT00002945|Radiation|radiation therapy|delivered to the cancer cells
5813483|NCT00002934|Procedure|long-term screening|
5813484|NCT00002835|Biological|Bleomycin Sulfate (BLM)|
5813485|NCT00002835|Biological|Filgrastim (G-CSF)|Arm 1: Administered subcutaneously (SC) beginning on day 5 and continuing until blood counts recover through Course 1 then 2 courses administered before PBSC harvest and same regimen with Course 2, then daily with Day 0 of infusion.
5813486|NCT00002835|Biological|Recombinant Interferon Alfa|
5813487|NCT00002835|Drug|Carmustine|Arm 1, Course 3, IV over 1 hour on day -6.
5813488|NCT00002835|Drug|Cisplatin (CDDP)|
5813489|NCT00002835|Drug|Cyclophosphamide|
5813490|NCT00002835|Drug|Cytarabine (ARA-C)|Arm 1, Course 3, every 12 hours on days -5 to -2.
5813491|NCT00002835|Drug|Etoposide (VP-16)|Course 1, IV over 2 hours every 12 hours on days 1-3; Course 3, every 12 hours on days -5 to -2.
5813492|NCT00002835|Drug|Idarubicin|
5813493|NCT00002835|Drug|Ifosfamide|During Course 1, IV continuously; Course 2, IV continuously on days 1-3.
5813494|NCT00002835|Drug|Leucovorin Calcium|
5813495|NCT00002835|Drug|Melphalan|
5813496|NCT00002835|Drug|Methotrexate|
5813497|NCT00002835|Drug|Methylprednisolone|
5813498|NCT00002835|Drug|mitoxantrone hydrochloride (DHAD)|Arm 1, Course 2, IV on day 1.
5813499|NCT00002835|Drug|Vincristine Sulfate|
5813500|NCT00002835|Procedure|Peripheral Blood Stem Cell Transplantation|Infusion of stem cells on Day 0.
5813501|NCT00002835|Radiation|Radiation Therapy|
5813502|NCT00002822|Drug|carboplatin|
5813503|NCT00002822|Drug|cisplatin|
5813504|NCT00002822|Drug|cyclophosphamide|
5813505|NCT00002822|Drug|doxorubicin hydrochloride|
5813506|NCT00002822|Drug|etoposide|
5813507|NCT00002822|Drug|ifosfamide|
5813508|NCT00002822|Drug|mesna|
5813509|NCT00002822|Drug|vincristine sulfate|
5813510|NCT00002822|Radiation|radiation therapy|
5813511|NCT00058864|Device|Energy absorbing and distributing trochanteric pad|
5813512|NCT00058851|Procedure|Manual lymph drainage|
5813513|NCT00058851|Procedure|Combined physiotherapy|
5813514|NCT00058851|Procedure|Compression bandaging|
5813515|NCT00058838|Drug|sumanirole|
5813516|NCT00058825|Biological|Campath 1H|Day -5 to Day -2: Campath 1H dose schedule as per institutional SOP.
5813517|NCT00058825|Drug|Fludarabine|Day -5 to Day -2: Fludarabine 30 mg/m2.
5813518|NCT00058825|Procedure|Stem Cell Transplant|Day 0: Donor stem cells infused.
5813519|NCT00058825|Radiation|Total Body Irradiation (TBI)|Day -6: Total body irradiation of 600 cGy as two doses without blocks at a rate of less than or equal to 10 cGy/minute.
5813520|NCT00058825|Drug|FK506 (Tacrolimus) or Cyclosporine|Day -2: FK506 or Cyclosporine as medically indicated to prevent GvHD.
5813521|NCT00058812|Biological|EBV specific T cells|One injection of 2x10^7 cells/m2 from Day 45 post transplant. If EBV DNA levels remain elevated above 1000 copies/ug or the patient has persistent disease they will be eligible to receive up to 5 additional injections of CTLs at the original dose at monthly intervals.
5813522|NCT00058799|Biological|Dose Level 1|Leukemic Blasts 2 x 10^7; IL-2 Fibroblasts 2 x 10^7; CD40L Fibroblasts 2 x 10^5
5813523|NCT00058799|Biological|Dose Level 2|Leukemic Blasts 2 x 10^7; IL-2 Fibroblasts 2 x 10^7; CD40L Fibroblasts 2 x 10^5
5813524|NCT00058799|Biological|Dose Level 3|Leukemic Blasts 2 x 10^7; IL-2 Fibroblasts 2 x 10^7; CD40L Fibroblasts 4.2 x 10^7
5813525|NCT00058786|Biological|Injection of IL-2-secreting CD40L-expressing autologous B-CLL cells|Patients may be treated with a minimum of three up to six injections of their IL-2-secreting and CD40L-expressing autologous B-CLL cells, separated by one to two weeks in an immunological treatment window, i.e. in the absence of concurrent cytotoxic therapy. Any patient whose disease regresses after the administration of 6 injections may be offered further injections (i.e. more than 6 injections) of tumor vaccine at the dose level previously administered, if enough vaccines are available. Patients will receive a fixed dose of IL-2 secreting B-CLL cells throughout the entire treatment protocol (see Section 5.8), determined by previous studies in acute leukemia and in neuroblastoma, in which this level of IL-2 production has been safe. The dose escalation of CD40L-expressing cells is designed to reach the IL2/CD40L ratio shown to be effective in our preclinical models of neuroblastoma and lymphoma.
5813526|NCT00058773|Drug|Infusion of EBV Specific Cytotoxic T-Lymphocytes|"EBV specific cytotoxic T-lymphocytes will be given by intravenous injection over 1-10 minutes.~Each patient will receive two injections, 14 days apart."
5813527|NCT00058760|Behavioral|NIA intervention (after school health promotion didactic program)|
5813528|NCT00058747|Drug|Autologous HSP-70 Protein-Peptide Complex (AG-858) Plus Gleevec™.|
5813529|NCT00058734|Biological|Dendritic Cells Pulsed with HIV antigens|
5813530|NCT00058721|Drug|I-123-5-IA85380|
5813531|NCT00058682|Drug|Anidulafungin|
5813532|NCT00002777|Drug|exemestane|
5813541|NCT00002701|Drug|mitoxantrone hydrochloride|
5813542|NCT00002701|Drug|thioguanine|
5813543|NCT00002701|Drug|tretinoin|
5813544|NCT00002701|Procedure|allogeneic bone marrow transplantation|
5813545|NCT00002701|Procedure|autologous bone marrow transplantation|
5813546|NCT00002701|Radiation|radiation therapy|
5813547|NCT00002695|Genetic|DNA stability analysis|
5813548|NCT00002695|Genetic|microsatellite instability analysis|
5813549|NCT00002695|Genetic|mutation analysis|
5813550|NCT00002695|Other|laboratory biomarker analysis|
5813551|NCT00002693|Biological|filgrastim|
5813552|NCT00002693|Drug|carboplatin|
5813553|NCT00002693|Drug|topotecan hydrochloride|
5813554|NCT00002669|Biological|aldesleukin|
5813555|NCT00002669|Biological|recombinant interferon alfa|
5813556|NCT00002669|Drug|cisplatin|
5813557|NCT00002669|Drug|dacarbazine|
5813558|NCT00058656|Procedure|Infusion of Activated & Expanded Autologous T Cells|
5813559|NCT00002658|Biological|filgrastim|
5813560|NCT00002658|Drug|amsacrine|
5813561|NCT00002658|Drug|cyclophosphamide|
5813562|NCT00002658|Drug|cytarabine|
5813563|NCT00002658|Drug|daunorubicin hydrochloride|
5813564|NCT00002658|Drug|etoposide|
5813565|NCT00002658|Drug|idarubicin|
5813566|NCT00002658|Drug|mitoxantrone hydrochloride|
5813567|NCT00002658|Drug|thioguanine|
5813568|NCT00002658|Drug|tretinoin|
5813569|NCT00002658|Procedure|allogeneic bone marrow transplantation|
5813570|NCT00002658|Procedure|autologous bone marrow transplantation|
5813571|NCT00002658|Procedure|peripheral blood stem cell transplantation|
5813572|NCT00002658|Radiation|radiation therapy|
5813573|NCT00002653|Drug|carmustine|
5813574|NCT00002653|Drug|cyclophosphamide|
5813575|NCT00002653|Drug|doxorubicin hydrochloride|
5813576|NCT00002653|Drug|melphalan|
5813577|NCT00002653|Drug|prednisone|
5813578|NCT00002653|Radiation|radiation therapy|
5813579|NCT00002575|Procedure|conventional surgery|
5813580|NCT00002575|Procedure|laparoscopic surgery|
5813581|NCT00002550|Drug|cisplatin|
5813582|NCT00002550|Drug|etoposide|
5813583|NCT00002550|Procedure|conventional surgery|
5813584|NCT00002550|Radiation|radiation therapy|
5813585|NCT00002539|Biological|filgrastim|
5813586|NCT00002539|Drug|cisplatin|
5813587|NCT00002539|Drug|doxorubicin hydrochloride|
5813588|NCT00002539|Procedure|conventional surgery|
5813589|NCT00058617|Biological|Injection of EBV Specific CTLs|"Each patient will receive two injections, 14 days apart, according to the following dosing schedules:~Group One Day 0 2x10^7 cells/m2 Day 14 2x10^7 cells/m2~Group Two Day 0 2x10^7 cells/m2 Day 14 1x10^8 cells/m2~Group Three Day 0 1x10^8 cells/m2 Day 14 2x 10^8 cells/m2~If patients with active disease have stable disease or a partial response by the RECIST criteria at their 8 week or subsequent evaluations they are eligible to receive up to 6 additional doses of CTLs at monthly intervals-each of which will consist of the same cell number as their second injection. Patients will not be able to receive additional doses until the initial safety profile is completed at 6 weeks following the second infusion."
5813590|NCT00058604|Biological|Intravenous injection of EBV specific CTLs|Each patient will receive injections of 2x10e7 , 5x10e7 , or 10e8 CTLs/m2 via IV injection. 6 weeks = 1 course
5813591|NCT00058591|Biological|Intravenous injection of EBV specific CTLS|"The dose levels for this study are as follows:~Level Dose~2 x 107 CTLs/m2~5 x 107 CTLs/m2~1 x 108 CTLs/m2~If patients have a clinical response to the first infusion defined by an improvement in the fatigue score or resolution of clinical abnormalities such as lymphadenopathy or an improvement in laboratory parameters such as a decrease in VCA titer or reduction in free EBV DNA they will be eligible to receive up to 3 additional injections of CTLs at the original dose at 3 monthly intervals."
5813592|NCT00058578|Drug|Cyclophosphamide|
5813593|NCT00058578|Drug|Mesna|
5813594|NCT00058578|Drug|G-CSF|
5813595|NCT00058578|Procedure|Leukopheresis|
5813596|NCT00058578|Procedure|Total Body Irradiation|
5813597|NCT00058552|Drug|Pertuzumab (rhuMAb 2C4)|
5813598|NCT00058539|Drug|rhuMAb 2C4 (pertuzumab)|
5813599|NCT00058526|Biological|Immunotherapeutic SB719125 (Primary)|Intramuscular injection
5813600|NCT00058487|Drug|epirubicin hydrochloride|
5813601|NCT00058487|Drug|thalidomide|
5813602|NCT00058474|Drug|capecitabine|825 mg/m2 oral daily 5 days a week on days of planned RT
5813603|NCT00058474|Drug|fluorouracil|225 mg/m2 IV daily continuous infusion
5813604|NCT00058474|Drug|oxaliplatin|50 mg/m2 IV 5 days a week on days of planned RT
5813605|NCT00058474|Radiation|radiation therapy|Given 5 days a week for 5-6 weeks
5813606|NCT00058461|Drug|ifosfamide|Given IV
5813607|NCT00058461|Drug|etoposide|Given IV
5813608|NCT00058461|Biological|rituximab|Given IV
5813609|NCT00058461|Drug|carboplatin|Given IV
5813610|NCT00058461|Biological|filgrastim|Given SC
5813611|NCT00058461|Drug|methotrexate|Given IT
5813612|NCT00058461|Drug|cytarabine|Given IT
5813613|NCT00058461|Other|laboratory biomarker analysis|Correlative studies
5813614|NCT00058448|Drug|docetaxel|
5813615|NCT00058435|Biological|abagovomab|
5813616|NCT00058422|Biological|darbepoetin alfa|
5813617|NCT00058422|Biological|filgrastim|
5813618|NCT00058422|Biological|rituximab|
5813619|NCT00058422|Drug|cyclophosphamide|
5813620|NCT00058422|Drug|doxorubicin hydrochloride|
5813621|NCT00058422|Drug|prednisone|
5813622|NCT00058422|Drug|vincristine sulfate|
5813623|NCT00058422|Radiation|indium In 111 ibritumomab tiuxetan|
5813624|NCT00058422|Radiation|yttrium Y 90 ibritumomab tiuxetan|
5813625|NCT00058396|Biological|lumiliximab|
5813626|NCT00058370|Drug|cisplatin|
5813627|NCT00058370|Drug|lomustine|
5813628|NCT00058370|Drug|vincristine sulfate|
5813629|NCT00058370|Procedure|adjuvant therapy|
5813630|NCT00058370|Radiation|iodine I 131 monoclonal antibody 3F8|
5813631|NCT00058370|Radiation|radiation therapy|
5813632|NCT00058357|Drug|lidocaine|
5813633|NCT00058357|Other|placebo|
5813634|NCT00058331|Biological|epoetin alfa|
5813635|NCT00058318|Drug|capecitabine|Capecitabine will be given 625 mg/m^2 (1250 mg/m^2/day) by mouth twice a day on day 1-21 for every cycle (1 cycle =28 days) until disease progression
5813636|NCT00058318|Drug|gemcitabine hydrochloride|Gemcitabine will be given 900 mg/m^2 by intravenous infusion over 30 minutes on day 1, 8, and 15 for every cycle (1 cycle = 28 days) until disease progression.
5813637|NCT00058305|Drug|bryostatin 1|Given IV
5813638|NCT00058305|Drug|vincristine sulfate|Given IV
5813639|NCT00058305|Other|laboratory biomarker analysis|Correlative studies
5813640|NCT00058292|Biological|filgrastim|Given at a dose of 5 μg/kg, subcutaneously daily, beginning on Day 0 (stem cell transplant day) until white blood cells measure greater than 1500/ul.
5813641|NCT00058292|Biological|rituximab|Intravenous infusion of 250 mg/m2 on treatment days -22 and -14 (day 0 = stem cell transplant).
5813642|NCT00058292|Drug|Carmustine|Part of high dose BEAM chemotherapy given on study (a combination of carmustine, etoposide, cytarabine, and melphalan). Carmustine is given at a dose of 300 mg/m2 intravenous infusion over a 2 hour period on treatment day -6 (Day 0 = stem cell transplant).
5813643|NCT00058292|Drug|cytarabine|Part of high dose BEAM chemotherapy given on study (a combination of carmustine, etoposide, cytarabine, and melphalan). Cytarabine is given at a dose of 100 mg/m2 intravenous infusion over a 1 hour period, every 12 hours on treatment days -5, -4, -3, and -2, for a total of 8 doses (Day 0 = stem cell transplant).
5813644|NCT00058292|Drug|etoposide|Part of high dose BEAM chemotherapy given on study (a combination of carmustine, etoposide, cytarabine, and melphalan). Etoposide is given at a dose of 100 mg/m2 intravenous infusion over a 2 hour period every 12 hours on treatment days -5, -4, -3, and -2, for a total of 8 doses (Day 0 = stem cell transplant).
5813645|NCT00058292|Drug|melphalan|Part of high dose BEAM chemotherapy given on study (a combination of carmustine, etoposide, cytarabine, and melphalan). Melphalan is given at a dose of 140 mg/m2 as an intravenous infusion over a 1 hour period on treatment day -1 (Day 0 = stem cell transplant).
5813646|NCT00058292|Procedure|peripheral blood stem cell transplantation|On day 0, a minimum of 2.0 X 106 CD34+ cells/kg unselected peripheral blood progenitor cells (PBPC) will be reinfused following institutional guidelines for the reinfusion procedure.
5813647|NCT00058292|Radiation|yttrium Y 90 ibritumomab tiuxetan|Patients will receive 90Y2B8 at a variable dose on treatment day -14 (Day 0 = stell cell transplant). The initial dose calculated to deliver no more than 100 cGy to critical organs (liver, lung). Doses will be escalated based on cohort of enrollment.
5813648|NCT00058279|Biological|aldesleukin|
5813649|NCT00058279|Biological|ipilimumab|
5813650|NCT00058266|Dietary Supplement|genistein|Given orally
5813651|NCT00058266|Procedure|conventional surgery|Patients undergo surgery
5813652|NCT00058253|Drug|tanespimycin|Given IV
5813653|NCT00058253|Drug|docetaxel|Given IV
5813654|NCT00058240|Drug|alvocidib|Given IV
5813655|NCT00058227|Drug|alvocidib|Given IV
5813656|NCT00058227|Drug|fludarabine phosphate|Given IV
5813657|NCT00058227|Biological|rituximab|Given IV
5813658|NCT00058227|Other|pharmacological study|Correlative studies
5813659|NCT00058214|Drug|perifosine|Given orally
5813660|NCT00058214|Other|laboratory biomarker analysis|Correlative studies
5813661|NCT00058201|Drug|fluorouracil|Given IV
5813662|NCT00058201|Drug|gemcitabine hydrochloride|Given IV
5813663|NCT00058201|Drug|leucovorin calcium|Given IV
5813664|NCT00058201|Other|clinical observation|No intervention
5813665|NCT00058188|Dietary Supplement|cholecalciferol|Given orally
5813666|NCT00058188|Drug|calcium gluconate|Given orally
5813667|NCT00058188|Drug|zoledronic acid|Given IV
5813668|NCT00058149|Drug|gemcitabine hydrochloride|
5813669|NCT00058149|Drug|oxaliplatin|
5813670|NCT00058123|Drug|poly ICLC|
5813671|NCT00058097|Drug|tipifarnib|Given orally
5813672|NCT00058097|Radiation|radiation therapy|Undergo radiation therapy
5813673|NCT00058084|Drug|ixabepilone|Given IV
5813674|NCT00058084|Drug|mitoxantrone hydrochloride|Given IV
5813675|NCT00058084|Drug|prednisone|Given orally
5813676|NCT00058071|Drug|amifostine trihydrate|
5813677|NCT00058058|Procedure|MRI|Breast contralateral to the breast diagnosed with cancer was scanned prior to initiation of chemotherapy and within 90 days of a negative mammogram of the study breast. A recent (within 90 days) negative or benign mammogram (defined by final BI RADS category 1 or 2) and negative or benign clinical breast exam of the study breast were required for entry into the study.
5813678|NCT00058045|Biological|aldesleukin|
5813679|NCT00058045|Biological|recombinant human stem cell factor|
5813680|NCT00058032|Other|screening questionnaire administration|
5813681|NCT00058032|Procedure|annual screening|
5813682|NCT00058019|Drug|ixabepilone|Given IV
5813683|NCT00058006|Drug|celecoxib|
5813684|NCT00058006|Procedure|adjuvant therapy|
5813685|NCT00057993|Biological|trastuzumab|
5813686|NCT00057993|Drug|exemestane|
5813687|NCT00057980|Drug|celecoxib|
5813688|NCT00057980|Drug|epirubicin hydrochloride|
5813689|NCT00057967|Biological|alemtuzumab|Will be administered as a two-hour IV infusion with a target dose of 30 milligrams three times a week for a maximum of 12 weeks.
5813690|NCT00057954|Procedure|Extracorporeal Photopheresis|Day -7 to -4: Extracorporeal Photopheresis may be given as an outpatient therapy on two consecutive days any time between days -7 to -4. This must be performed on UVAR or XTS photopheresis machines (Therakos, Inc.) according to standard procedure as per manufacturer's guidelines.
5813691|NCT00057954|Drug|Pentostatin|Day -3, -2: Pentostatin 4 mg/m²/d by continuous IV infusion (Total dose = 8 mg/m²)
5813692|NCT00057954|Radiation|Total body irradiation (TBI)|Day -1: TBI 400 cGy total dose given in two 200cGy doses. Patients who have received TBI for a previous transplant or radiation as part of previous treatment for a lymphoid malignancy will receive only 200 cGy in 1 dose.
5813693|NCT00057954|Procedure|Allogeneic bone marrow transplantation|Day 0: Infusion of unmanipulated allogeneic bone marrow or stem cells. Minimum cell dose of 2 x 106 CD34 cells/kg recipient and no more than 10 x 10^6 CD34/kg
5813694|NCT00057954|Drug|Cyclosporin (CSA)|Cyclosporin A or tacrolimus will be administered according to institutional GVHD prophylaxis protocols. Therapeutic levels will be maintained and patients will be switched to oral agents when they can tolerate
5813695|NCT00057954|Drug|Mycophenolate mofetil (MMF)|At day 100 MMF will be introduced at a dose of 250 mg po BID and cyclosporine or tacrolimus will be tapered according to the discretion of the investigator. The dosage will be escalated to a maximum of 2 g/d at the discretion of the attending physician and will be tapered and discontinued at 12 months if there is no active cGVHD. Doses should be given on an empty stomach
5813696|NCT00057954|Drug|Methotrexate (MTX)|"The dose of Methotrexate is based on the corrected ideal body weight for patients with > 33% above ideal weight.~Day +1 MTX 15 mg/m² IV push; Day +3 MTX 10 mg/m² IV push (May be omitted if patient develops mouth sores.)"
5813697|NCT00057941|Drug|anastrozole|Given orally
5813698|NCT00057941|Drug|gefitinib|Given orally
5813699|NCT00057941|Drug|fulvestrant|Given intramuscularly
5813700|NCT00057941|Other|laboratory biomarker analysis|Correlative studies
5813701|NCT00057928|Drug|cisplatin|
5813702|NCT00057928|Drug|gemcitabine hydrochloride|
5813703|NCT00057928|Drug|paclitaxel|
5813704|NCT00057915|Biological|CEA peptide 1-6D|CAP-1(6D) peptide-pulsed, matured, autologous human DC produced by the AastromReplicell™ Cell Production System
5813705|NCT00057889|Biological|ipilimumab|
5813706|NCT00057876|Drug|Gemcitabine|"Induction: Patients receive the first cycle of gemcitabine 1000 mg/m^2 intravenously once per week for 6 weeks followed by 1 week rest.~Consolidation: Following the week of rest, treatment resume with gemcitabine 1000 mg/m^2 administered intravenously once per week for 3 weeks, followed by 1 week rest, for 5 (4-week) cycles."
5813707|NCT00057876|Radiation|radiation therapy|"Induction: Patients receive gemcitabine 600 mg/m^2 intravenous infusion over 30-60 minutes once a week for 6 weeks while receiving radiation therapy. The first gemcitabine dose is given on the first day of radiation therapy (prior to radiation), then weekly thereafter. All patients on Arm B receive radiation therapy Monday through Friday (no radiation on Saturday or Sunday), weeks 1-6, with once/week gemcitabine. The radiation dose per fraction is 180 cGy prescribed to the isocenter. The total dose of radiation is 5040 cGy given in 28 fractions over 5 1/2 weeks.~Consolidation: Additional cycles of gemcitabine begin approximately 4 weeks after completion of radiation therapy."
5813708|NCT00057863|Drug|Paclitaxel|Given IV
5813709|NCT00057863|Drug|Oxaliplatin|Given IV
5813710|NCT00057850|Drug|cisplatin|
5813711|NCT00057850|Drug|ixabepilone|
5813712|NCT00057837|Biological|G-CSF|G-CSF will be administered subcutaneously at a dose of 5 mcg/kg once a day starting on day 11 until WBC recovery > 10,000 dL.
5813713|NCT00057837|Drug|Cisplatin|Arm PET: 20 mg/m2 IV on days 8, 9 and 10 of each cycle following Etoposide. Arm PIE: 20 mg/m2 IV on days 1 and 8 of each cycle following Irinotecan.
5813714|NCT00057837|Drug|Etoposide|Arm PET: 70 mg/m2 IV over 60 minutes on days 8, 9 and 10 of each cycle. Arm PIE: 85 mg/m2 orally (divided into 2 doses, 12 hours apart) on day 3 and 10 of each cycle.
5813715|NCT00057837|Drug|Irinotecan|50 mg/m2 IV over 90 minutes on days 1 and 8 of each cycle (Arm PIE only).
5813716|NCT00057837|Drug|Topotecan|Topotecan 0.75 mg/m2 IV over 30 minutes on days 1,2 and 3 of each cycle (Arm PET only).
5813717|NCT00057811|Drug|doxorubicin hydrochloride|Given IV, IT, or orally
5813718|NCT00057811|Drug|cyclophosphamide|Given IV
5813719|NCT00057811|Drug|methotrexate|Given IV or IT
5813720|NCT00057811|Drug|rasburicase|Given IV
5813721|NCT00057811|Drug|leucovorin calcium|Given IV or orally
5813722|NCT00057811|Drug|prednisone|Given IV or orally
5813723|NCT00057811|Drug|methylprednisolone|Given IV or orally
5813724|NCT00057811|Biological|filgrastim|Given subcutaneously
5813725|NCT00057811|Biological|rituximab|Given IV
5813726|NCT00057811|Drug|cytarabine|Given IT
5813727|NCT00057811|Drug|etoposide|Given IV
5813728|NCT00057811|Drug|vincristine sulfate|Given IV
5813729|NCT00057811|Drug|hydrocortisone sodium succinate|Given IT
5813730|NCT00057811|Other|laboratory biomarker analysis|Correlative studies
5813731|NCT00057798|Drug|gemcitabine hydrochloride|
5813732|NCT00057798|Drug|vinorelbine ditartrate|
5813733|NCT00057798|Genetic|cytogenetic analysis|
5813734|NCT00057798|Genetic|loss of heterozygosity analysis|
5813735|NCT00057798|Genetic|microarray analysis|
5813736|NCT00057798|Procedure|conventional surgery|
5813737|NCT00057798|Procedure|neoadjuvant therapy|
5813738|NCT00057785|Drug|cisplatin|100 mg/m^2 intravenously on days 1, 22, and 43 and 80 mg/m^2 intravenously on days 71, 99, and 127
5813739|NCT00057785|Drug|fluorouracil|1000 mg/m^2/day as 96-hour continuous infusion on days 71-74, 99-102, and 127-130
5813740|NCT00057785|Radiation|Intensity modulated radiation therapy|The gross tumor and lymph node metastasis, Planning Target Volume (PTV) 70 (Clinical Target Volume [CTV] 70 with a 5 mm margin) will receive 70 Gy in 33 fractions at 2.12 Gy per fraction. Treatment will be delivered once daily, 5 fractions per week, over 6 weeks and 3 days.
5813741|NCT00057759|Drug|sildenafil citrate|
5813742|NCT00057759|Other|Placebo|Placebo
5813743|NCT00057746|Radiation|Prophylactic cranial irradiation, 2.5 Gy fx|Prophylactic cranial irradiation, 2.5 Gy once daily, M-F, in 10 fractions (fx) for a total of 25 Gy
5813744|NCT00057746|Radiation|Prophylactic cranial irradiation, 2.0 Gy fx|Prophylactic cranial irradiation, 2.0 Gy once daily, M-F, in 18 fractions (fx) for a total of 36 Gy
5813745|NCT00057746|Radiation|Prophylactic cranial irradiation, 1.5 Gy fx|Prophylactic cranial irradiation, 1.5 Gy twice daily, M-F, in 24 fractions (fx) for a total dose of 36 Gy
5813746|NCT00057733|Procedure|psychosocial assessment and care|
5813747|NCT00057733|Procedure|quality-of-life assessment|
5813748|NCT00030368|Drug|bortezomib|Given IV
5813749|NCT00030368|Drug|paclitaxel|Given IV
5813750|NCT00030368|Other|laboratory biomarker analysis|Correlative studies
5813751|NCT00023673|Drug|carboplatin|
5813753|NCT00023673|Radiation|three-dimensional conformal radiation therapy|
5813754|NCT00004079|Drug|SarCNU|Given PO
5813755|NCT00004079|Other|pharmacological study|Correlative studies
5813756|NCT00004079|Other|laboratory biomarker analysis|Correlative studies
5813757|NCT00057720|Drug|TLK286 HCl for injection|
5813758|NCT00057720|Drug|topotecan hydrochloride for injection|
5813759|NCT00057720|Drug|doxorubicin HCl liposome injection|
5813760|NCT00057681|Drug|Lithium carbonate|Titrated until blood level is 1.1 to 1.3 mEq/L
5813761|NCT00057681|Drug|Valproate|Titrated until blood level is 111 to 125 ug/mL
5813762|NCT00057681|Drug|Risperidone|Titrated by weight until dose is 2.0 mg BID to 3.0 mg BID
5813763|NCT00057668|Behavioral|Multi-Setting Early Intervention|
5813764|NCT00057668|Behavioral|Community Intervention|
5813765|NCT00057642|Drug|Sertraline|
5813766|NCT00057642|Drug|Venlafaxine Extended Release|
5813767|NCT00057629|Behavioral|Prolonged Exposure (PE)|Prolonged Exposure (PE) consists of 10 weekly 90-minute treatment sessions, which may be extended up to 20 sessions, depending on client response. Treatment procedures include education about common reactions to trauma, breathing retraining, prolonged (repeated) exposure to trauma memories, repeated in vivo exposure to situations the client is avoiding due to trauma-related fear, and discussion of thoughts and feelings related to exposure exercises as well as beliefs about self and the world.
5813768|NCT00057629|Behavioral|Treatment as usual group therapy (TUGT)|TUGT is delivered in ten weekly sessions, with 5 to 7 members and two counselors per group. There is not a formal, structured format for these groups; the counselors are sensitive to the participants' needs and follow their lead in terms of content covered in discussions and exercises. TUGT is conceptualized as supportive counseling and is based on the idea that members gain social support and information from one another.
5813769|NCT00057629|Behavioral|Supportive counseling (SC)|Supportive counseling is an individual therapy delivered in 10 weekly, 90 minute sessions. During this treatment, the therapist helps the patient identify daily stresses that may or may not be related to traumatic events and discusses them in a supportive non-directive mode with a problem-solving orientation. The therapist uses active listening, encouragement of expression of feelings, praise, and encouragement. The goal of this present-focused treatment is to provide support and to help the client to identify problems and stresses of daily living and to help her cope with these. No instructions for exposure are given.
5813770|NCT00057616|Drug|CC-5013|
5813771|NCT00057603|Procedure|Deep Brain Stimulation|Deep brain stimulation sends electrical signals to specific parts of the brain, which block the impulses that cause neurological dysfunction.
5813772|NCT00057590|Behavioral|Care manager outreach and monitoring|
5813773|NCT00057577|Behavioral|Cognitive Therapy|CT sessions occur weekly during acute treatment and monthly during continuation. Acute treatment may last up to 18 months. Remitted patients are continued on medication for up to 36 months from initial randomization until they meet criteria for recovery. At recovery, patients receiving combined treatment discontinue CT.
5813774|NCT00057577|Drug|Medications|Antidepressant medication is distributed as clinically indicated with augmentation and ancillary medications as needed. Acute treatment may last up to 18 months. Remitted patients are continued on medication for up to 36 months from the point of initial randomization until they meet criteria for recovery. All recovered patients are randomized a second time to either maintenance medication or medication withdrawal. Patients are then monitored over 36 months to ascertain risk for recurrence of depressive symptoms.
5813775|NCT00057564|Drug|A (Thalidomide + Dexamethasone)|Thalidomide 50mg/day + Dexamethasone 40mg
5813776|NCT00057564|Drug|B (Placebo + Dexamethasone)|Placebo + Dexamethasone 40mg
5813777|NCT00057707|Drug|Modafinil|Placebo 1 week-Wash out 1 week - Drug 1 week (or vice versa)
5813778|NCT00057707|Procedure|Functional MRI|
5813779|NCT00057707|Procedure|Neuropsychological Testing|
5813780|NCT00057551|Behavioral|Brief Supportive Psychotherapy|brief supportive psychotherapy
5813781|NCT00057551|Behavioral|CBASP|psychotherapy developed for chronic depression
5813782|NCT00057551|Drug|Medication Only|antidepressant medication
5813783|NCT00057538|Behavioral|Mantram Repetition|
5813784|NCT00057525|Biological|Anthrax|Doses will range from 5 _g to 100 _g rPA, and at each dose-level, rPA will either be combined with phosphate-buffered saline (PBS) or adsorbed to Alhydrogel
5813785|NCT00057525|Biological|Alhdryogel or PBS|Doses will range from 5 _g to 100 _g rPA, and at each dose-level, rPA will either be combined with phosphate-buffered saline (PBS) or adsorbed to Alhydrogel
5813786|NCT00057512|Drug|M4N|Dose escalation study of M4N administered intratumorally on days 1, 8 and 15. Dose escalated in cohorts on three weeks schedule to a target of 20 mg/cm3 tumor volume.
5813787|NCT00057499|Biological|IBC-VS01|IBC-VS01
5813788|NCT00057499|Biological|IBC-VS01 placebo|IBC-VS01 placebo
5813789|NCT00057486|Drug|IL-12|
5813790|NCT00057473|Drug|carboplatin + irinotecan|Solution, IV, Carbopaltin AUC 4 mg/ml.min every 21 days; irinotecan 12 mg/m2/day x 10 days , Minimum of two cycles of chemotherapy projected to be up to 6.
5813791|NCT00057473|Drug|irinotecan|Solution, IV, irinotecan 12 mg/m2/day x 10 days, minimum of two cycles of chemotherapy projected to be up to 6.
5813792|NCT00057447|Drug|Interferon Gamma-1b|100 or 200 mcg, SQ, 3x per week
5813793|NCT00057447|Drug|Rituximab|375 mg per square meters, IV, 1x per week
5813794|NCT00057434|Drug|multivitamin|
5813795|NCT00057421|Drug|prednisolone|
5813796|NCT00057460|Drug|Talampanel|
5813797|NCT00057408|Drug|olanzapine (Zyprexa)|Olanzapine tablets given po at a dosage of 2.5 - 20 mg per day for up to 12 weeks.
5813798|NCT00057408|Drug|Placebo|Matching Placebo
5813799|NCT00057395|Drug|Aroplatin (Liposomal NDDP, L-NDDP)|
5813800|NCT00057382|Drug|T138067 intravenous|
5813801|NCT00057382|Drug|doxorubicin intravenous|
5813802|NCT00057369|Drug|dalbavancin|
5813803|NCT00057356|Drug|conivaptan|IV
5813804|NCT00057356|Drug|placebo|IV
5813805|NCT00057343|Drug|Zevalin (ibritumomab tiuxetan)|
5813806|NCT00057343|Drug|Rituxan (rituximab)|
5814004|NCT00055757|Drug|gemcitabine hydrochloride|Given IV
5814005|NCT00055757|Other|laboratory biomarker analysis|Correlative studies
5813807|NCT00057330|Biological|HSV vaccine or SB208141, GSK Biologicals' glycoprotein D (gD)-Alum/3-deacylated form of Monophosphoryl Lipid A (MPL) candidate genital herpes vaccine|the vaccine was administered intramuscularly in the non-dominant deltoid
5813808|NCT00057330|Biological|Havrix™, GlaxoSmithKline (GSK) Biologicals' licensed Hepatitis A vaccine|the vaccine was administered intramuscularly in the non-dominant deltoid
5813809|NCT00057317|Drug|Ro 205-2349|
5813810|NCT00057304|Drug|Insulin sensitizer|
5813811|NCT00057291|Behavioral|Responsive caregiving|Responsive caregiving consisted of operational circumstances and training of caregivers.
5813812|NCT00057031|Drug|DN-101 (calcitriol)|
5813813|NCT00057278|Drug|gabapentin|
5813814|NCT00057265|Drug|telbivudine or lamivudine|
5813815|NCT00057200|Procedure|Telephone, videophone care|
5813816|NCT00057187|Behavioral|Contracting, Prompting and Reinforcing|
5813817|NCT00057239|Drug|Radafaxine|
5813818|NCT00057226|Drug|Radafaxine|
5813819|NCT00057213|Drug|Radafaxine|
5813820|NCT00057174|Drug|Disease management of gastroesophageal reflux disease|
5813821|NCT00057161|Behavioral|Coordinated Representative Payeeship with Case Management|
5813822|NCT00057148|Procedure|massage treatment|
5813823|NCT00057135|Behavioral|Unit of use medication packaging|
5813824|NCT00057135|Behavioral|Mailed reminders to patient when medication refills are due|
5813825|NCT00057135|Behavioral|Note to Mental Health Provider when refill is overdue|
5813826|NCT00057135|Procedure|Aligning all prescriptions to fall due on same date|
5813827|NCT00057122|Drug|Isoniazid|300mg
5813828|NCT00057122|Drug|Rifapentine|Rifapentine 900 mg
5813829|NCT00057122|Drug|Rifampin|Rifampin 600 mg
5813830|NCT00057096|Procedure|On-site vs. referral methods of care|
5813831|NCT00057083|Other|Telemedicine Care|
5813832|NCT00057070|Procedure|Smoking cessation information, collection, and dissemination|
5813833|NCT00057057|Behavioral|Telephone Care|
5813834|NCT00057044|Behavioral|education and reminder|
5813835|NCT00057018|Procedure|Constraint-induced movement therapy|
5813836|NCT00057005|Drug|CAMPATH-1H|Day-8 through Day-6 according to institutional SOPs
5813837|NCT00057005|Drug|Anti-CD45|Day-5 400 μg/kg
5813838|NCT00057005|Drug|Ara-C|day-7 through day-5 3000 mg/m2 q 12h
5813839|NCT00057005|Drug|Cyclophosphamide|Day-7 through Day-6 45 mg/kg
5813840|NCT00057005|Drug|Mesna|Days -7 and -6 45 mg/kg divided into 5 doses
5813841|NCT00057005|Radiation|Total Body Irradiation|150 cGy x 2 (5/6 matched related) 180 cGy x 2 (5/6 matched unrelated)
5813842|NCT00056992|Drug|ADI-PEG 20|
5813843|NCT00056979|Drug|CAMPATH-1H|
5813844|NCT00056979|Drug|Anti-CD45|
5813845|NCT00056979|Drug|FK506|
5813846|NCT00056979|Drug|Fludarabine|
5813847|NCT00056966|Drug|ANTI-CD45|400ug/kg Day-5 through Day-2
5813848|NCT00056966|Drug|CAMPATH-1H|Day -8 through Day -6 Dosed per Institutional SOP
5813849|NCT00056966|Drug|FK506|Day -2 through Day 30 dose adjusted to maintain level between 5-15 ng/ml.
5813850|NCT00056966|Drug|Fludarabine|Day-8 through Day-5 30 mg/m2
5813851|NCT00056966|Radiation|Total Body Irradiation|Day-1 single dose 450 cGy
5813852|NCT00056966|Procedure|Stem cell infusion|Patients will receive peripheral blood stem cells from a HLA matched or one antigen mismatched related or unrelated donor (target CD34+ cell count >2 x 106/kg). When peripheral stem cells are unavailable or insufficient, bone marrow (target mononuclear cell count >2 x 108/kg) will be substituted.
5813853|NCT00056953|Behavioral|Peer mentoring program|
5813854|NCT00056940|Behavioral|Stages of Change|
5813855|NCT00056940|Behavioral|Safety Check approach|
5813856|NCT00056927|Behavioral|Anti-smoking Socialization Program|
5813857|NCT00056875|Drug|recombinant human keratinocyte growth factor|
5813858|NCT00056836|Drug|rhuFab V2 (ranibizumab)|
5813859|NCT00056823|Drug|rhuFab V2 (ranibizumab)|
5813860|NCT00056862|Drug|Peginterferon alfa-2a|Peginterferon alfa-2a 90 mcg/week
5813861|NCT00056862|Drug|Peginterferon alfa-2a|180 mcg/week
5813862|NCT00056862|Drug|Ribavirin|800 mg/day
5813863|NCT00056810|Drug|4-aminopyridine (4-AP)|
5813864|NCT00056797|Biological|ALVAC HIV vaccine (vCP1452)|
5813865|NCT00056797|Drug|Interleukin-2|
5813866|NCT00056758|Biological|Autologous Dendritic Cell HIV Vaccination|
5813867|NCT00056745|Biological|TBC-3B|
5813868|NCT00056693|Drug|Sunitinib|Sunitinib 50 mg by oral capsule daily for 4 weeks in every 6 week cycle until progression or unacceptable toxicity
5813869|NCT00056680|Behavioral|Psychoeducational video|
5813870|NCT00056680|Behavioral|Infant massage|
5813871|NCT00056680|Behavioral|Brazelton Neonatal Behavioral Assessment Scale|
5813872|NCT00056667|Behavioral|Relaxation response and cognitive behavioral therapy|The cognitive behavioral therapy program wwill incorporate relaxation training, a modified version of the RA treatment program developed by Bradley et al (1987) and shown to be effective. The cognitive behavioral techniques include problem solving, relabeling, enhanced awareness of pain behaviors, and attention refocusing. The RR component includes instruction in diaphragmatic breathing along with progressive skeletal muscle relaxation. The intervention will be modified from the original program in that neither biofeedback training nor participation of family members will be included. Consequently, the number of weekly group sessions will be reduced from 14 to 12. Homework will be given at the end of each session, to be completed and brought in for review to the next session.
5813873|NCT00056667|Behavioral|Relaxation response|The relaxation response (RR) consists of a set of integrated physiological changes elicited when a participant engages in the repetitive mental action of focusing on a word, phrase, or image, while passively ignoring distracting thoughts. These changes include decreased oxygen consumption, heart rate, arterial blood pressure, respiratory rate, and arterial blood lactate, along with slight increases in skeletal muscle blood flow. The long-term physiologic changes of participants eliciting the relaxation response are consistent with reduced norepinephrine end organ responsivity. These latter changes provide a plausible psychophysiological mechanism for longer-term actions of the RR.
5814006|NCT00055731|Drug|bicalutamide|
5813874|NCT00056667|Other|RA education|RA education programs have been widely used to supplement routine medical care. They have been found to be of modest benefit, particularly in terms of knowledge about the condition and its treatment. The long-term effects on pain and level of function are less. When used as an attention control, such educational programs have been found to be as credible and as well attended as the active experimental treatment (Professor Francis Keefe, Personal Communication). In this study, patients randomized to the control condition will receive 8 weekly sessions of RA education, in groups of 6-10 patients each, using portions of the Arthritis Self-Management Program and incorporating printed and videotaped materials available from the Arthritis Foundation.
5813875|NCT00056654|Drug|Leuprolide acetate|45 mg Intramuscular injection 6 month depot formulation
5813876|NCT00056641|Drug|tipranavir|
5813877|NCT00056641|Drug|ritonavir|
5813878|NCT00056641|Drug|saquinavir|
5813879|NCT00056641|Drug|amprenavir|
5813880|NCT00056641|Drug|lopinavir|
5813881|NCT00056706|Procedure|Transient deafferentation|
5813882|NCT00056628|Device|The COGNIShunt® System|
5813883|NCT00056589|Drug|catridecacog|Single doses of rFXIII administered intravenously (IV) to two subjects in each of the five dose levels (2, 6, 20, 50 and 75 U/kg).
5813884|NCT00056576|Drug|Zonisamide|
5813885|NCT00056563|Device|Bilateral Deep Brain Stimulation|The DBS site (STN or GPi) will be assigned on a random basis at the time the patient enters the surgical phase of the trial.
5813886|NCT00056563|Other|best medical therapy|"Participants will initially be randomized to DBS or to 6 months of best medical therapy. BMT participants will then proceed into the surgical phase of the trial. Effective 08/05/05, randomization to the BMT arm has been discontinued since the study has sufficient information to compare the outcomes of DBS and BMT patients at 6 months."
5813887|NCT00056550|Biological|Recombinant Human Antithrombin (rhAT)|Biological/Vaccine: Recombinant human antithrombin(rhAT) Phase III clinical trial.
5813888|NCT00056537|Drug|ABR-217620|Starting dose: 0.5 mcg/kg; subsequent doses: individual, based on pre-treatment level of anti-SEA/E-120, body weight, and toxicities observed in prior patients on study; IV; one bolus injection each day for 5 consecutive days; up to 3 cycles
5813889|NCT00056524|Drug|AVP-923|
5813890|NCT00056511|Drug|Fresh garlic or garlic supplements|
5813891|NCT00056498|Drug|Placebo|Placebo capsule daily for 16 weeks
5813892|NCT00056498|Drug|Risperdal|Risperdal 4 mg per day for 16 weeks
5813893|NCT00056485|Behavioral|Pleasant Events-Based Behavioral Intervention|
5813894|NCT00056472|Drug|Olanzapine|10-20mg/day
5813895|NCT00056472|Drug|Sertraline|150-200mg/day
5813896|NCT00056472|Other|placebo|tablet that ressembles sertraline but contains no medication
5813897|NCT00012454|Drug|E-Selectin nasal spray|
5813898|NCT00056459|Drug|Vatalanib|
5813899|NCT00056446|Drug|Vatalanib|
5813900|NCT00056433|Drug|Hydroxyurea|
5813901|NCT00056433|Drug|L-Arginine|
5813902|NCT00056433|Drug|Sildenafil|
5813903|NCT00056407|Drug|Dutasteride|After successful completion of the placebo run-in phase, subjects who continue to meet eligibility requirements will be randomized into the double-blind phase of the study and issued a 6-month supply of study drug. Subjects will self-administer study drug once daily dosing of 0.5mg of dutasteride orally for up to 4 years.
5813904|NCT00056407|Drug|Placebo|After successful completion of the placebo run-in phase, subjects who continue to meet eligibility requirements will be randomized into the double-blind phase of the study and issued a 6-month supply of study drug. Subjects will self-administer study drug once daily orally for up to 4 years.
5813905|NCT00056394|Behavioral|Comprehensive Coping Skills Training|10 weekly, 80-minute coping skills treatment sessions, followed by a series of six biweekly follow-up telephone calls.
5813906|NCT00056394|Behavioral|Arthritis Education Sessions|10 weekly, 80-minute treatment sessions, followed by a series of six biweekly follow-up telephone calls. Participants will learn about the nature and treatment of rheumatoid arthritis as well as the benefits of exercise and joint protection.
5813907|NCT00056394|Behavioral|Standard Care|Usual care from participants' rheumatologists but no treatment sessions.
5813908|NCT00056381|Drug|Anidulafungin|
5813909|NCT00056368|Drug|Anidulafungin|
5813910|NCT00056368|Drug|Fluconazole|
5813911|NCT00056329|Drug|Vitamin E|1,000 international units twice daily for three years
5813912|NCT00056329|Drug|multivitamin|once daily for three years
5813913|NCT00056329|Drug|Placebo|Placebo twice daily for three years
5813914|NCT00056355|Drug|UVADEX and UVAR XTS Photopheresis System|
5813915|NCT00056316|Behavioral|Basic Education|Participants receive 37-page Basic Care Guide (Education Institute, 2001) and bi-weekly telephone calls by a trained staff member.
5813916|NCT00056316|Behavioral|Behavioral Skills Training: Experimental|Multicomponent behavioral intervention using 10-session video series (Steffen, et al., 2001) workbook (Steffen, et al., 2001), and weekly telephone coaching sessions.
5813917|NCT00056303|Behavioral|Attachment and Biobehavioral Catch-up|Attachment and Biobehavioral Catch-up is a 10 session in-home intervention that targets synchrony, nurturance, and calming parental behavior.
5813918|NCT00056303|Behavioral|Developmental Education for Families|Developmental Education for Families is a 10-session in home intervention that targets children's cognitive development.
5813919|NCT00056290|Biological|VEGF|3 sets of injections, at 2 week intervals
5813920|NCT00056290|Biological|VEGF|3 sets of injections, at 2 week intervals
5813921|NCT00056277|Drug|lamotrigine|
5813922|NCT00056264|Drug|Infliximab|
5813923|NCT00056251|Procedure|H&P; ECG; Blood tests; voiding diary; Cystoscopy|
5813924|NCT00056238|Drug|NC-758 (Anti amyloidotic [Aß] agent)|
5813925|NCT00056225|Drug|Folate|
5813926|NCT00056225|Drug|Vitamin B6|
5813927|NCT00056225|Drug|Vitamin B12|
5813928|NCT00056212|Behavioral|Yoga|
5813929|NCT00056212|Behavioral|Exercise|
5813930|NCT00056173|Drug|GTI-2040|
5813931|NCT00056199|Drug|EYE001|
5813932|NCT00056160|Drug|CC-5013|Subjects in the CC-5013/Dex treatment group took 25 mg of lenalidomide orally once daily on Days 1 to 21 and a matching placebo capsule once daily on Days 22 to 28 of each 28-day cycle.
5813933|NCT00056160|Drug|Dexamethasone|Subjects in the CC-5013/Dex and Placebo/Dex treatment groups took 40 mg of dexamethasone orally once daily on Days 1 to 4, 9 to 12, and 17 to 20 of each 28-day cycle for the first 4 cycles of therapy. Beginning with Cycle 5, the dose of dexamethasone was reduced to 40 mg orally once daily on Days 1 to 4 for the remaining cycles.
5813934|NCT00056147|Drug|denufosol tetrasodium (INS37217)|
5813935|NCT00056134|Biological|Dendritic cell vaccine plus denileukin difitox|
5813936|NCT00056095|Biological|therapeutic allogeneic lymphocytes|
5813937|NCT00056095|Drug|cyclophosphamide|
5813938|NCT00056095|Drug|cyclosporine|
5813939|NCT00056095|Drug|fludarabine phosphate|
5813940|NCT00056095|Procedure|allogeneic bone marrow transplantation|
5813941|NCT00056095|Procedure|peripheral blood stem cell transplantation|
5813942|NCT00056082|Drug|celecoxib|Celecoxib daily for 12 months
5813943|NCT00056069|Other|questionnaire administration|Participants complete questionnaires regarding caregiver demands and family information over 25-30 minutes within 3-4 months of the initiation of the child's treatment and at the completion of the first year of the child's treatment.
5813944|NCT00056056|Drug|bexarotene|The recommended initial dosage of Bexarotene (75 mg Bexarotene capsules to be administered according to body surface area) for patients entered in this trial is 300 mg/m2 /once a day, taken orally, till CCR, PD, unacceptable toxicity, 16 weeks of treatment, whichever comes first
5813945|NCT00056056|Drug|methoxypsoralen|The dose of methoxypsoralen, as conventional capsules or liquid-filled capsules, is based on the patient's weight. The standard dose of 0.6 mg/kg will be given to all patients three times weekly - Increasing dose of PUVA according to a set protocol after a Minimal Phototoxic Dose (MPD) testing.
5813946|NCT00056056|Procedure|UV light therapy|Initial UVA light exposure times should be based on the minimal phototoxic dose (MPD) for the specific light source being used. MPD can be determined by irradiating several skin areas 2 cm in diameter with varying light exposure times and determining the exposure time that produces erythema at 72 hours. The initial dose of UVA administered will be 70% of the MPD. The dose of UVA for the subsequent UVA sessions will be increased according to a standard protocol consisting of 20% increments with each successive treatment session depending on the presence of erythema.
5813947|NCT00056030|Biological|cetuximab|
5813948|NCT00056030|Drug|fluorouracil|
5813949|NCT00056030|Drug|leucovorin calcium|
5813950|NCT00056030|Drug|oxaliplatin|
5813951|NCT00056004|Drug|zileuton|
5813952|NCT00055991|Drug|bexarotene|This drug is a retinoid. The anti-tumor action of retinoids, as well as their potential in chemoprevention, supports the need to further identify the spectrum of responsive tumors, to identify the molecular mechanisms associated with retinoid action, and to identify and develop new retinoids that have unique properties and an improved therapeutic index.
5813953|NCT00055978|Drug|celecoxib|Given orally. 400mg twice daily for 6 months.
5813954|NCT00055978|Other|placebo|Given orally
5813955|NCT00055965|Drug|carboplatin|
5813956|NCT00055965|Drug|cisplatin|
5813957|NCT00055965|Drug|gemcitabine hydrochloride|
5813958|NCT00055952|Drug|exatecan mesylate|
5813959|NCT00055939|Drug|exatecan mesylate|
5813960|NCT00055926|Drug|CP-724,714|
5813961|NCT00055913|Biological|bevacizumab|Given IV
5813962|NCT00055913|Drug|erlotinib hydrochloride|Given orally
5813963|NCT00055913|Other|laboratory biomarker analysis|Correlative studies
5813964|NCT00055887|Drug|carboplatin|
5813965|NCT00055887|Drug|cisplatin|
5813966|NCT00055887|Drug|efaproxiral|
5813967|NCT00055887|Drug|gemcitabine hydrochloride|
5813968|NCT00055887|Drug|paclitaxel|
5813969|NCT00055887|Drug|vinorelbine ditartrate|
5813970|NCT00055887|Procedure|radiation therapy|
5813971|NCT00055874|Biological|recombinant interferon alfa|
5813972|NCT00055874|Drug|cytarabine|
5813973|NCT00055874|Drug|hydroxyurea|
5813974|NCT00055874|Drug|imatinib mesylate|
5813975|NCT00055874|Procedure|allogeneic bone marrow transplantation|
5813976|NCT00055874|Procedure|autologous bone marrow transplantation|
5813977|NCT00055874|Procedure|peripheral blood stem cell transplantation|
5813978|NCT00055861|Biological|bevacizumab|Given IV
5813979|NCT00055861|Drug|docetaxel|Given IV
5813980|NCT00055861|Other|laboratory biomarker analysis|Correlative studies
5813981|NCT00055848|Genetic|cytogenetic analysis|
5813982|NCT00055848|Genetic|gene mapping|
5813983|NCT00055848|Genetic|microarray analysis|
5813984|NCT00055835|Drug|carboplatin|*AUC=5 (by modified Calvert formula), IV, over 15 minutes; given q 21 days for a maximum of 3 cycles (1 cycle = 21 days)
5813985|NCT00055835|Drug|cisplatin|75 mg/m2 (maximum dose 150 mg), IV, rapid infusion; given q 21 days for 2 cycles (1 cycle = 21 days)
5813986|NCT00055835|Drug|gemcitabine hydrochloride|800 mg/m2, IV, over 30 minutes; given on Days 1 & 8, q 21 days, for a maximum of 3 cycles (1 cycle = 21 days)
5813987|NCT00055835|Drug|paclitaxel|200 mg/m2, IV, over 3 hours; given q 21 days for a maximum of 3 cycles (1 cycle = 21 days)
5813988|NCT00055835|Procedure|neoadjuvant therapy|Neoadjuvant chemotherapy (paclitaxel, carboplatin, and gemcitabine)
5813989|NCT00055835|Radiation|radiation therapy|Radiation treatments will be delivered once daily. Treatment will be given 5 days per week at a dose of 180 to 200 cGy per day. All fields will be treated everyday.
5813990|NCT00055822|Biological|oblimersen sodium|
5813991|NCT00055822|Drug|fluorouracil|
5813992|NCT00055822|Drug|leucovorin calcium|
5813993|NCT00055822|Drug|oxaliplatin|
5813994|NCT00055809|Biological|PEG-interferon alfa-2b|Given SC
5813995|NCT00055809|Biological|bevacizumab|Given IV
5813996|NCT00055809|Other|laboratory biomarker analysis|Optional correlative studies
5813997|NCT00055783|Biological|apolizumab|
5813998|NCT00055770|Drug|erlotinib hydrochloride|Given orally
5813999|NCT00055770|Drug|docetaxel|Given IV
5814000|NCT00055770|Other|laboratory biomarker analysis|Correlative studies
5814001|NCT00055770|Other|pharmacological study|Correlative studies
5814002|NCT00055757|Drug|tipifarnib|Given orally
5814008|NCT00055731|Drug|cyproterone acetate|
5814009|NCT00055731|Drug|docetaxel|
5814010|NCT00055731|Drug|estramustine phosphate sodium|
5814011|NCT00055731|Drug|flutamide|
5814012|NCT00055731|Drug|goserelin acetate|
5814013|NCT00055731|Drug|leuprolide acetate|
5814014|NCT00055731|Drug|nilutamide|
5814015|NCT00055731|Drug|triptorelin|
5814016|NCT00055731|Procedure|conventional surgery|
5814017|NCT00055731|Procedure|neoadjuvant therapy|
5814018|NCT00055731|Radiation|radiation therapy|
5814019|NCT00055718|Dietary Supplement|silymarin|
5814020|NCT00055705|Biological|PV701|
5814021|NCT00055692|Biological|bevacizumab|Given orally
5814022|NCT00055679|Drug|cyclophosphamide|
5814023|NCT00055679|Drug|epirubicin hydrochloride|
5814024|NCT00055679|Drug|fluorouracil|
5814025|NCT00055666|Drug|beclomethasone dipropionate|
5814026|NCT00055653|Biological|anti-thymocyte globulin|
5814027|NCT00055653|Biological|filgrastim|
5814028|NCT00055653|Drug|busulfan|
5814029|NCT00055653|Drug|cyclophosphamide|
5814030|NCT00055653|Drug|cyclosporine|
5814031|NCT00055653|Drug|fludarabine phosphate|
5814032|NCT00055653|Drug|melphalan|
5814033|NCT00055653|Drug|methylprednisolone|
5814034|NCT00055653|Procedure|umbilical cord blood transplantation|
5814035|NCT00055653|Radiation|radiation therapy|
5814036|NCT00055640|Biological|rituximab|Rituximab IV over 3-6 hours.Treatment repeats every 21 days for 3-8 courses.
5814037|NCT00055640|Drug|cyclophosphamide|Cyclophosphamide IV over 30 minutes. Treatment repeats every 21 days for 3-8 courses.
5814038|NCT00055640|Drug|doxorubicin hydrochloride|Doxorubicin IV over 5 minutes. Treatment repeats every 21 days for 3-8 courses.
5814039|NCT00055640|Drug|prednisone|Oral prednisone on days 1-5. Treatment repeats every 21 days for 3-8 courses.
5814040|NCT00055640|Drug|vincristine sulfate|Vincristine IV over 5 minutes on day 1. Treatment repeats every 21 days for 3-8 courses.
5814041|NCT00055640|Genetic|microarray analysis|genetic testing
5814042|NCT00055614|Drug|topotecan hydrochloride|
5814043|NCT00055614|Procedure|adjuvant therapy|
5814044|NCT00055601|Drug|cisplatin|Induction: 15 mg/m2 as a 60-minute infusion on days 1, 2, 3, 8, 9, 10, 15, 16, and 17; Consolidation: 15 mg/m2 as a 60-minute infusion on days 1, 2, 8, and 9; Adjuvant: 35 mg/m2 as a 60-minute infusion on days 1 and 8 of each 21-day cycle for 4 cycles.
5814045|NCT00055601|Drug|fluorouracil|Induction: 400 mg/m2 as a 24-hour infusion on days 1, 2, 3, 15, 16, and 17; Consolidation: 400 mg/m2 as a 24-hour infusion on days 1, 2, 3, 8, 9, and 10.
5814046|NCT00055601|Drug|paclitaxel|Induction: 50 mg/m2 as a 60-minute infusion on days 1, 8, and 15; Consolidation: 50 mg/m2 as a 60-minute infusion on days 1 and 8; Adjuvant: 50 mg/m2 as a 60-minute infusion on days 1 and 8 of each 21-day cycle for 4 cycles.
5814047|NCT00055601|Radiation|radiation therapy|Induction: External beam irradiation, 1.6 Gy, will be given to the pelvis in the first treatment followed by an interfraction period of at least 4-6 hours. During the second treatment, 1.5 Gy will be delivered to the whole bladder for the first five sessions (7.5 Gy) then to the tumor plus a margin for eight sessions (12. Gy). Consolidation: Consolidation therapy will start 7-14 days following a cystoscopic re-evaluation demonstrating a complete response to the induction therapy. 1.5 Gy (per fraction) will be given to the pelvis in two treatment fractions per day, with an interfraction period of at least 4-6 hours.
5814048|NCT00055601|Drug|Gemcitabine|Adjuvant: 1000 mg/m2 over 30-60 minutes on days 1 and 8 of each 21-day cycle for 4 cycles.
5814049|NCT00055601|Procedure|Radical cystectomy|Operable patients with pT1 or worse tumor response on re-evaluation following induction therapy will have radical cystectomy.
5814050|NCT00022139|Drug|carboplatin|
5814051|NCT00022139|Drug|fluorouracil|
5814052|NCT00022139|Drug|paclitaxel|
5814053|NCT00022139|Procedure|conventional surgery|
5814054|NCT00022139|Radiation|radiation therapy|
5814055|NCT00005028|Drug|bryostatin 1|
5814056|NCT00005028|Drug|paclitaxel|
5814057|NCT00055588|Procedure|Locomotor training|
5814058|NCT00055575|Drug|Transderm Scopolamine|
5814059|NCT00055562|Drug|CC 5013|
5814060|NCT00055536|Drug|natalizumab|
5814061|NCT00055523|Drug|Adalimumab (D2E7)|
5814062|NCT00055549|Drug|Dextromethorphan|
5814063|NCT00055549|Drug|Lorazepam|
5814064|NCT00055510|Drug|BO-653|
5814065|NCT00055497|Biological|Double-blind (DB) adalimumab placebo|Double-blind nonactive matching subcutaneous injection
5814066|NCT00055497|Biological|DB adalimumab 40 mg eow|Double-blind adalimumab 40 mg every other week by subcutaneous injection
5814067|NCT00055497|Biological|DB adalimumab 40 mg ew|Double-blind adalimumab 40 mg every week by subcutaneous injection
5814068|NCT00055497|Biological|OL adalimumab 40 mg|Open-label adalimumab every other week or every week by subcutaneous injection
5814069|NCT00055484|Drug|zonisamide|
5814070|NCT00055471|Drug|ZD4054 10 mg|1 x 10 mg oral tablets once daily
5814071|NCT00055471|Drug|ZD4054 15 mg|1 x 10 mg + 2 x 2.5 mg oral tablets once daily
5814072|NCT00055471|Drug|ZD4054 22.5 mg|2 x 10 mg + 2 x 2.5 mg oral tablets once daily
5814073|NCT00055445|Drug|IdB 1016|
5814074|NCT00055432|Drug|Gemzar and Alimta|
5814075|NCT00055419|Biological|Cetuximab|400 mg/m2 loading dose Week 1, followed by 250 mg/m2 weekly until disease progression
5814076|NCT00055393|Drug|Bupropion|18 subjects in this randomly controlled double blind study received bupropion.
5814077|NCT00055393|Drug|Placebo|21 subjects received Placebo.
5814078|NCT00055380|Procedure|Oral cytobrushing|
5814079|NCT00055367|Drug|natalizumab|
5814080|NCT00055354|Procedure|Acupuncture|
5814081|NCT00055354|Behavioral|Cognitive Behavioral Therapy|
5814082|NCT00055341|Drug|Peginterferon alfa-2a|
5814083|NCT00055341|Drug|Ribavirin|
5814084|NCT00055328|Behavioral|Problem-Solving Treatment for Primary Care|
5814158|NCT00054626|Drug|gemcitabine hydrochloride|
5814159|NCT00054626|Procedure|adjuvant therapy|
5814085|NCT00055315|Behavioral|Systems Training for Emotional Predictability and Problem Solving (STEPPS)|STEPPS is a 20-week, manual-based, psychoeducational group treatment that combines skills training with cognitive-behavioral techniques. It includes a systems component to train family members, friends, and significant others.
5814086|NCT00055315|Behavioral|Treatment As Usual (TAU)|
5814087|NCT00055302|Drug|Arimidex 1 mg|Arimidex (anastrozole) 1mg once daily by mouth
5814088|NCT00055263|Drug|DN-101|
5814089|NCT00055250|Drug|Gemcitabine|
5814090|NCT00055250|Drug|LY293111|
5814091|NCT00055250|Drug|placebo|
5814092|NCT00055237|Biological|Bevacizumab|15 mg/kg day intravenously on day 1, day 8, then every 3 weeks.
5814093|NCT00055224|Device|Acoustic startle|Threat condition
5814094|NCT00055224|Device|Electric Shock|Threat condition
5814095|NCT00055198|Drug|daptomycin|
5814096|NCT00055185|Drug|CD4-IgG2 (PRO 542)|
5814097|NCT00055146|Drug|ONTAK|
5814098|NCT00055133|Drug|Micellar Paclitaxel for Injection|
5814099|NCT00055159|Procedure|Pulse-sprayed injection of recombinant tissue plasminogen activator (rtPA)|
5814100|NCT00055120|Drug|Emtricitabine/tenofovir disoproxil fumarate|
5814101|NCT00055120|Drug|Lopinavir/ritonavir|
5814102|NCT00055120|Drug|Stavudine|
5814103|NCT00055107|Drug|Nitazoxanide|
5814104|NCT00055081|Behavioral|Critical Time Intervention|
5814105|NCT00055068|Behavioral|Cognitive Behavioral Therapy (CBT)|
5814106|NCT00055068|Behavioral|Relaxation Training|
5814107|NCT00055042|Drug|Vitamin E|
5814108|NCT00054977|Drug|GM-CT-01|IV infusion over 30 minutes of 6 Dosages escalated from 30 to 280 mg/m2, given for 4 consecutive days in a 28 days cycle.
5814109|NCT00054977|Drug|5-fluorouracil|IV infusion over 30 minutes at Dosage of 500 mg/m2, given in-combination with GM-CT-01, for 4 consecutive days in a 28 days cycle.
5814110|NCT00054964|Drug|Albuterol HFA-BOI|Albuterol HFA breath operated inhaler, 90 mcg/sprau
5814111|NCT00054964|Drug|Albuterol HFA-MDI|Albuterol HFA multi-dose inhaler
5814112|NCT00054951|Drug|MTC-DOX for Injection|
5814113|NCT00054938|Drug|pravastatin|
5814114|NCT00054938|Drug|aspirin|
5814115|NCT00054938|Drug|ramipril|
5814116|NCT00054938|Drug|Vitamins: B6, B12, and folate|
5814117|NCT00054938|Behavioral|heart health educational program|
5814118|NCT00054925|Behavioral|Personal contact (PC)|This arm uses brief, individual contacts on a monthly basis which emphasize core elements of weight maintenance. Monthly contacts with an interventionist occur for 30 months after the end of Phase I. Face-to-face contacts occur approximately every four months (e.g., three annually), with telephone contacts occurring every month between FTF contacts.
5814119|NCT00054925|Behavioral|Interactive technology (IT)|The website utilizes collaborative goal setting and problem-solving strategies to identify contingent action plans for perceived obstacles to success. In order to tailor the intervention to the needs of the participant, the action plan can be updated anytime and as frequently as desired by the individual. Participants are encouraged to input data on weight, food records, physical activity, and goals on a weekly basis. Participants are not restricted to logging on to the website only once a week. Rather, participants have the option of logging on to the website to enter data, communicate with other participants, or to seek other information, as frequently as they wish.
5814120|NCT00054912|Biological|EP2101|
5814121|NCT00054899|Biological|EP2101|
5814122|NCT00054886|Drug|SU-011,248|
5814123|NCT00054873|Drug|tezacitabine|
5814124|NCT00054873|Drug|5-fluorouracil|
5814125|NCT00054860|Biological|EP HIV-1090|
5814126|NCT00054847|Procedure|saphenous vein graft|Saphenous vein harvested from the arm is used as a conduit for CABG.
5814127|NCT00054847|Procedure|radial artery graft|Radial artery harvested from the arm is used as a conduit for CABG.
5814128|NCT00054834|Drug|hLL2 (epratuzumab)|
5814129|NCT00054821|Procedure|Ankle distraction permitting motion|External fixator is applied to ankle joint for 85 - 95 days; ankle motion is permitted
5814130|NCT00054821|Procedure|Ankle distraction without motion|External fixator is applied to ankel joint for 85 - 95 days; ankle motion is not permitted
5814131|NCT00054808|Drug|gallium nitrate|
5814132|NCT00054795|Drug|Motexafin Gadolinium|
5814133|NCT00054730|Drug|CX516 (Ampalex®)|
5814134|NCT00054756|Drug|TRH (Thyrotropin Releasing Hormone)|
5814135|NCT00054743|Procedure|Blood draw|
5814136|NCT00054717|Drug|Tipranavir|
5814137|NCT00054717|Drug|Ritonavir(r)|
5814138|NCT00054717|Drug|Comparator Protease Inhibitor (CPI)|
5814139|NCT00054704|Drug|Riluzole|Riluzole
5814140|NCT00054704|Drug|Placebo|Placebo
5814141|NCT00054691|Drug|Iressa|250 mg by mouth daily
5814142|NCT00054678|Drug|MyoCell™|
5814143|NCT00054678|Device|MyoCath™|
5814144|NCT00050531|Drug|Gleevec|400 mg orally twice daily.
5814145|NCT00050531|Drug|Peg-alpha interferon (Peg-Intron)|PEG-IFN 0.5 mcg/kg each week subcutaneously.
5814146|NCT00050531|Drug|Sargramostim (GM-CSF)|125 mcg/m^2 three times per week subcutaneously.
5814147|NCT00054665|Drug|PS-341|1.3 mg/m^2 intravenous injection days 1, 4, 8, 11 every 3 weeks
5814148|NCT00054665|Drug|Etoposide|50 mg/m^2 day continuous intravenous infusion (CIV) days 1-4, 96 hour infusion. Repeat cycle every 21 days.
5814149|NCT00054665|Drug|Doxorubicin|10 mg/m^2 day CIV days 1-4, 96 hour infusion. Repeat cycle every 21 days.
5814150|NCT00054665|Drug|Vincristine|0.4 mg/m^2 day CIV days 1-4, 96 hour infusion. Repeat cycle every 21 days.
5814151|NCT00054665|Drug|Cyclophosphamide|750 mg/m^2 day IV day 5 bolus. Repeat cycle every 21 days.
5814152|NCT00054665|Drug|Prednisone|60 mg/m^2 by mouth twice a day days 1-5. Repeat cycle every 21 days.
5814153|NCT00054665|Drug|Filgrastim|300 micrograms subcutaneously days 6 to absolute neutrophil count recovery greater than or equal to 5000/mm^3. Repeat cycle every 21 days.
5814154|NCT00054639|Biological|oblimersen sodium|Given IV
5814155|NCT00054639|Biological|rituximab|Given IV
5814156|NCT00054639|Other|laboratory biomarker analysis|Correlative studies
5814157|NCT00054626|Drug|cisplatin|
5814161|NCT00054613|Procedure|Extracorporeal Photopheresis|
5814162|NCT00054600|Drug|Methoxsalen|
5814163|NCT00054600|Procedure|Extracorporeal Photopheresis|
5814164|NCT00054587|Biological|Trastuzumab|8 mg/kg at month M6, followed by a maintenance dose of 6 mg/kg every 3 weeks for a 1 year (i.e. 18 injections in total)
5814165|NCT00054587|Drug|Cyclophosphamide|500 mg/m², D1 and every 3 weeks
5814166|NCT00054587|Drug|docetaxel|on day D1 of each cycle : dose: 75 mg/m², route: i.v. injection over 1 hour, every 3 weeks
5814167|NCT00054587|Drug|Epirubicin|100 mg/m², D1 and every 3 weeks
5814168|NCT00054587|Drug|Fluorouracil|500 mg/m², D1 and every 3 weeks
5814169|NCT00054574|Biological|panitumumab|
5814170|NCT00054561|Biological|recombinant interferon alfa|
5814171|NCT00054561|Dietary Supplement|vitamin E|
5814172|NCT00054561|Drug|isotretinoin|
5814173|NCT00054561|Procedure|adjuvant therapy|
5814174|NCT00054548|Biological|oblimersen sodium|Given IV
5814175|NCT00054548|Drug|paclitaxel|Given IV
5814176|NCT00054548|Other|laboratory biomarker analysis|Correlative studies
5814177|NCT00054548|Other|pharmacological study|Correlative studies
5814178|NCT00054535|Biological|aldesleukin|
5814179|NCT00054535|Biological|recombinant fowlpox-tyrosinase vaccine|
5814180|NCT00054535|Biological|vaccinia-tyrosinase vaccine|
5814181|NCT00054522|Dietary Supplement|calcitriol|
5814182|NCT00054522|Drug|dexamethasone|
5814183|NCT00054496|Drug|erlotinib hydrochloride|
5814184|NCT00054483|Drug|bortezomib|Given IV
5814185|NCT00054483|Other|laboratory biomarker analysis|Correlative studies
5814186|NCT00054483|Other|pharmacological study|Correlative studies
5814187|NCT00054470|Biological|trastuzumab|
5814188|NCT00054470|Drug|tipifarnib|
5814189|NCT00054457|Drug|capecitabine|
5814190|NCT00054457|Drug|docetaxel|
5814191|NCT00054444|Drug|Topotecan Hydrochloride Liposomes|Given IV
5814192|NCT00054444|Radiation|3-Dimensional Conformal Radiation Therapy|
5814193|NCT00054444|Drug|Cisplatin|Given IV
5814194|NCT00054431|Drug|imatinib mesylate|Given orally
5814195|NCT00054431|Drug|decitabine|Given IV
5814196|NCT00054431|Other|laboratory biomarker analysis|Correlative studies
5814197|NCT00054418|Dietary Supplement|calcium carbonate|calcium 600 mg daily administered orally for one year
5814198|NCT00054418|Dietary Supplement|vitamin D|vitamin D 400 U daily administered orally for one year
5814199|NCT00054418|Drug|risedronate sodium|risedronate 35 mg weekly administered orally
5814200|NCT00054418|Other|placebo|placebo tablet weekly administered orally for one year
5814201|NCT00054405|Biological|recombinant interleukin-12|Given IV
5814202|NCT00054405|Biological|aldesleukin|Given IV
5814203|NCT00054392|Drug|carboplatin|
5814204|NCT00054392|Drug|gemcitabine hydrochloride|
5814205|NCT00054392|Drug|paclitaxel|
5814206|NCT00054353|Drug|fludarabine phosphate|Given IV
5814207|NCT00054353|Drug|melphalan|Given IV
5814208|NCT00054353|Radiation|total-body irradiation|Undergo TBI
5814209|NCT00054353|Drug|mycophenolate mofetil|Given PO
5814210|NCT00054353|Drug|cyclosporine|Given PO
5814211|NCT00054353|Procedure|nonmyeloablative allogeneic hematopoietic stem cell transplantation|Undergo reduced-intensity allogeneic PBSCT
5814212|NCT00054353|Procedure|peripheral blood stem cell transplantation|Undergo reduced-intensity allogeneic PBSCT
5814213|NCT00054353|Other|laboratory biomarker analysis|Correlative studies
5814214|NCT00054340|Biological|anti-thymocyte globulin|
5814215|NCT00054340|Drug|busulfan|
5814216|NCT00054340|Drug|cyclophosphamide|
5814217|NCT00054340|Drug|cyclosporine|
5814218|NCT00054340|Drug|methotrexate|
5814219|NCT00054340|Procedure|allogeneic bone marrow transplantation|
5814220|NCT00054340|Procedure|peripheral blood stem cell transplantation|
5814221|NCT00054327|Drug|busulfan|Given orally 1mg/kg/dose (or 40mg/m2/dose for young children)
5814222|NCT00054327|Drug|cyclophosphamide|Given IV
5814223|NCT00054327|Drug|cytarabine|Given IV
5814224|NCT00054327|Radiation|radiation therapy|Patients undergo total body irradiation
5814225|NCT00054327|Drug|Etoposide|infusion
5814226|NCT00054327|Procedure|Stem Cell Transfusion|
5814227|NCT00054314|Drug|ortataxel|
5814228|NCT00054301|Procedure|adjuvant therapy|
5814229|NCT00054301|Procedure|conventional surgery|Patients undergo excisional biopsy or surgery.
5814230|NCT00054301|Radiation|intraoperative radiation therapy|Patients undergo excisional biopsy or surgery followed by an intraoperative dose of radiation to the tumor cavity.
5814231|NCT00054288|Drug|gemcitabine hydrochloride|
5814232|NCT00054288|Drug|irinotecan hydrochloride|
5814233|NCT00054275|Drug|docetaxel|Docetaxel IV infusion weekly for 3 weeks with a one-week break. One cycle is 4 weeks (28 days). Patients' actual weight will be used to calculate dose.
5814234|NCT00054275|Drug|erlotinib hydrochloride|OSI-774 will be taken 1 hour before or 2 hours after meals. Cycle 1 will be administered at dose level -1.If no grade 3 or 4 toxicity occurs during cycle 1, then the patient may proceed to be treated at dose level 0 for the remaining chemotherapy cycles.
5814235|NCT00054262|Drug|T900607|
5814236|NCT00054249|Drug|T900607|
5814237|NCT00054236|Biological|anti-thymocyte globulin|anti-thymocyte globulin (ATG) IV over at least 4 hours on days -2 to -1
5814238|NCT00054236|Biological|filgrastim|Patients receive filgrastim (G-CSF) subcutaneously beginning on day 7 and continuing until blood counts recover.
5814239|NCT00054236|Drug|cyclophosphamide|cyclophosphamide IV over 2 hours on days -3 to -2
5814240|NCT00054236|Drug|fludarabine phosphate|fludarabine IV over 30 minutes on days -8 to -4
5814241|NCT00054236|Procedure|umbilical cord blood transplantation|Patients undergo multiple unit umbilical cord blood transplantation on days 0-1.
5814242|NCT00054236|Drug|methylprednisolone|Patients unable to tolerate ATG may receive methylprednisolone IV over 1 hour on days -3 to -1.
5814243|NCT00054223|Procedure|psychosocial assessment and care|
5814244|NCT00054210|Drug|carboplatin|
5814245|NCT00054210|Drug|paclitaxel|
5814246|NCT00054210|Drug|paclitaxel poliglumex|
5814247|NCT00054197|Drug|gemcitabine hydrochloride|
5814248|NCT00054197|Drug|paclitaxel poliglumex|
5814249|NCT00054197|Drug|vinorelbine tartrate|
5814250|NCT00054184|Drug|docetaxel|
5814251|NCT00054184|Drug|paclitaxel poliglumex|
5814252|NCT00054171|Drug|aminolevulinic acid hydrochloride|
5814253|NCT00054158|Drug|dexamethasone|
5814254|NCT00054158|Drug|doxorubicin hydrochloride|
5814255|NCT00054158|Drug|thalidomide|
5814256|NCT00054158|Drug|vincristine sulfate|
5814257|NCT00054145|Drug|perifosine|
5814258|NCT00054132|Biological|Bevacizumab|Given IV
5814259|NCT00054132|Drug|Erlotinib Hydrochloride|Given PO
5814260|NCT00054132|Other|Laboratory Biomarker Analysis|Correlative studies
5814261|NCT00054119|Drug|Cositecan|Given IV
5814262|NCT00054119|Other|Pharmacological Study|Correlative studies
5814263|NCT00054106|Drug|buserelin|
5814264|NCT00054106|Drug|custirsen sodium|
5814265|NCT00054106|Drug|flutamide|
5814266|NCT00054106|Procedure|conventional surgery|
5814267|NCT00054106|Procedure|neoadjuvant therapy|
5814268|NCT00054067|Drug|cisplatin|
5814269|NCT00054067|Procedure|adjuvant therapy|
5814270|NCT00054067|Procedure|conventional surgery|
5814271|NCT00054067|Radiation|brachytherapy|
5814272|NCT00054067|Radiation|radiation therapy|
5814273|NCT00054054|Drug|cisplatin|
5814274|NCT00054054|Drug|docetaxel|
5814275|NCT00054054|Drug|fluorouracil|
5814276|NCT00054054|Radiation|radiation therapy|
5814277|NCT00054041|Biological|HspE7|Given subcutaneously
5814278|NCT00054041|Procedure|therapeutic conventional surgery|Undergo large loop excision
5814279|NCT00054041|Other|laboratory biomarker analysis|Correlative studies
5814280|NCT00054028|Drug|suramin|Given IV
5814281|NCT00054028|Drug|paclitaxel|Given IV
5814282|NCT00054028|Other|pharmacological study|Correlative studies
5814283|NCT00054015|Drug|triapine|
5814284|NCT00054002|Procedure|adjuvant therapy|Lung surgery
5814285|NCT00054002|Procedure|conventional surgery|Lung surgery
5814286|NCT00054002|Drug|porfimer sodium|iv
5814287|NCT00053989|Biological|anti-thymocyte globulin|iv
5814288|NCT00053989|Biological|graft-versus-tumor induction therapy|iv
5814289|NCT00053989|Biological|sargramostim|iv
5814290|NCT00053989|Biological|therapeutic allogeneic lymphocytes|iv
5814291|NCT00053989|Drug|cyclophosphamide|injection
5814292|NCT00053989|Drug|fludarabine phosphate|iv
5814293|NCT00053989|Drug|methylprednisolone|oral
5814294|NCT00053989|Drug|mycophenolate mofetil|oral
5814295|NCT00053989|Drug|tacrolimus|oral
5814296|NCT00053989|Procedure|allogeneic bone marrow transplantation|iv
5814297|NCT00053989|Procedure|peripheral blood stem cell transplantation|iv
5814298|NCT00053989|Procedure|umbilical cord blood transplantation|iv
5814299|NCT00053976|Biological|Daclizumab|
5814300|NCT00053976|Drug|methylprednisolone|
5814301|NCT00053976|Drug|Placebo|
5814302|NCT00053963|Drug|romidepsin|Given IV
5814303|NCT00053950|Drug|pyrazoloacridine|Given IV
5814304|NCT00053950|Biological|filgrastim|Given IV or SC
5814305|NCT00053950|Procedure|autologous bone marrow transplantation|Undergo autologous bone marrow transplantation
5814306|NCT00053950|Procedure|peripheral blood stem cell transplantation|Undergo peripheral blood stem cell transplantation
5814307|NCT00053950|Other|laboratory biomarker analysis|Correlative studies
5814308|NCT00053950|Other|pharmacological study|Correlative studies
5814309|NCT00053937|Drug|pirfenidone|
5814310|NCT00053924|Drug|perifosine|
5814311|NCT00053911|Drug|anastrozole|
5814312|NCT00053911|Drug|cyclophosphamide|
5814313|NCT00053911|Drug|docetaxel|
5814314|NCT00053911|Drug|epirubicin hydrochloride|
5814315|NCT00053911|Drug|fluorouracil|
5814316|NCT00053911|Drug|goserelin acetate|
5814317|NCT00053911|Drug|tamoxifen citrate|
5814318|NCT00053911|Procedure|adjuvant therapy|
5814319|NCT00053898|Drug|anastrozole|1 mg/day and placebo for 5 years
5814320|NCT00053898|Drug|tamoxifen citrate|20 mg/day and placebo for 5 years
5814321|NCT00053898|Radiation|Radiation Therapy|Adjuvant radiation therapy
5814322|NCT00053885|Drug|PTK787/ZK 222584|oral
5814323|NCT00053872|Drug|cisplatin|
5814324|NCT00053872|Drug|lomustine|
5814325|NCT00053872|Drug|vincristine sulfate|
5814326|NCT00053872|Procedure|adjuvant therapy|
5814327|NCT00053872|Radiation|radiation therapy|
5814328|NCT00053846|Drug|buspirone hydrochloride|The dose of buspirone will be 10 mg taken by mouth at bedtime for 3 days, then twice each day, in the morning and at bedtime for the remainder of the 28 day study period
5814329|NCT00053846|Drug|Placebo|Placebo
5814330|NCT00053833|Drug|irinotecan|
5814331|NCT00053820|Biological|aldesleukin|
5814332|NCT00053820|Biological|recombinant interferon alfa|
5814333|NCT00053820|Drug|fluorouracil|
5814334|NCT00053807|Biological|aldesleukin|
5814335|NCT00053807|Biological|recombinant interferon alfa|
5814336|NCT00053807|Drug|fluorouracil|
5814337|NCT00053807|Procedure|adjuvant therapy|
5814338|NCT00053794|Drug|perifosine|
5814339|NCT00053781|Drug|perifosine|
5814340|NCT00053768|Biological|filgrastim|
5814341|NCT00053768|Drug|EPOCH regimen|
5814342|NCT00053768|Drug|cyclophosphamide|
5814343|NCT00053768|Drug|doxorubicin hydrochloride|
5814344|NCT00053768|Drug|etoposide|
5814345|NCT00053768|Drug|prednisone|
5814346|NCT00053768|Drug|vincristine sulfate|
5814347|NCT00053768|Radiation|radiation therapy|
5814348|NCT00053716|Drug|Liprostin [liposomal Prostaglandin E1]|
5814349|NCT00045123|Drug|tarenflurbil|
5814350|NCT00045123|Procedure|adjuvant therapy|
5814351|NCT00028678|Drug|dalteparin|
5814352|NCT00028678|Radiation|radiation therapy|
5814353|NCT00017342|Drug|bryostatin 1|
5814354|NCT00017342|Drug|cytarabine|
5814355|NCT00053742|Drug|Modified Vaccinia Virus Ankara TBC-MVA|
5814356|NCT00053703|Drug|Risperidone|oral risperidone 0.5mg to 6mg daily for up to 52 weeks
5814357|NCT00053703|Drug|Olanzapine (enrollment closed in this treatment)|oral olanzapine 5-20mg per day for up to 52 weeks
5814358|NCT00053703|Drug|Molindone|oral molindone from 10-140mg/daily for up to 52 weeks
5814359|NCT00053690|Behavioral|Cognitive Behavior Treatment|
5814360|NCT00053677|Drug|Naltrexone|For subjects who were randomly assigned to naltrexone 50mg/day, 100mg/day, or 150mg/day.
5814361|NCT00053677|Drug|Placebo|For subjects who were randomly assigned to placebo.
5814362|NCT00053651|Behavioral|Survival Skills for Moms with New Babies|
5814363|NCT00053638|Drug|efavirenz|
5814364|NCT00053638|Drug|tenofovir|
5814365|NCT00053638|Drug|abacavir/lamivudine|
5814366|NCT00053625|Procedure|deep brain stimulation|Deep brain stimulation (DBS) is a surgical intervention used to treat movement disorders such as Parkinson's disease (PD). Target sites of stimulation may differ among patients. The Gpi and STN are two commonly targeted sites within the brain for treatment of PD, yet differences in outcomes between stimulation at the Gpi vs the STN (unilateral and bilateral) are not currently well understood.
5814367|NCT00053612|Drug|Vitamin A|
5814368|NCT00053599|Drug|Simvastatin|
5814369|NCT00053573|Biological|Myozyme|20 mg/kg to 40 mg/kg qow
5814370|NCT00053560|Drug|Prasterone (GL701)|
5814371|NCT00053547|Drug|paricalcitol injection|
5814372|NCT00053508|Biological|ACAM1000|Group 1 dose: 1.4 x 10-8th PFU/ml (350,000 PFU) Group 2 dose: 2.8 x 10-7th PFU/ml (70,000 PFU) Group 3 dose: 5.6 x 10-6th PFU/ml (14,000 PFU)
5814373|NCT00053508|Biological|vaccinia virus (calf lymph) smallpox vaccine: Dryvax|group 4 dose: 1.6 x 10-8th PFU/ml (250,000 PFU)
5814374|NCT00053495|Biological|Vaccinia virus: ACAM2000 smallpox vaccine|Group 1 dose: 1.0x10-8th PFU/ml Group 2 dose: 2.0x10-8th PFU/ml Group 3 dose: 1.0x10-7th PFU/ml Group 4 dose: 5.0x10-6th PFU/ml
5814375|NCT00053495|Biological|vaccinia virus (calf lymph): Dryvax|Group 5 dose: 1.0x10-8th PFU/ml
5814376|NCT00053482|Biological|ACAM2000 Smallpox Vaccine|Group 1 dose: 1.0x10-8th PFU/ml, Group 2 dose: 2.0x10-7th PFU/ml, Group 3 dose: 1.0x10-7th PFU/ml, Group 4 dose: 5.0x10-6th PFUL/ml
5814377|NCT00053482|Biological|Vaccinia virus (calf lymph) smallpox vaccine: Dryvax®|Group 5 dose: 1.0x10-8th PFU/ml
5814378|NCT00053443|Device|Medication Reminder System/Adherence Tracker|
5814379|NCT00053430|Drug|Thalidomide|Tablet taken orally daily
5814380|NCT00053430|Drug|Thalidomide placebo|Placebo tablet taken orally daily
5814381|NCT00053417|Drug|Placebo|Placebo for 15 weeks
5814382|NCT00053417|Drug|10 milligram (mg) fampridine-SR (4-aminopyridine, 4-AP)|"2 week up titration (10 mg)~12 weeks stable dose (10 mg)~1 week down titration (10 mg)"
5814383|NCT00053417|Drug|15 mg fampridine-SR (4-aminopyridine, 4-AP)|"10 mg twice daily for 1 week~15 mg twice daily for 14 weeks~2 week up titration (10 mg x 1 week, 15 mg x 1 week)~12 weeks stable dose (15 mg)~1 week down titration (10 mg)"
5814384|NCT00053417|Drug|20 mg fampridine-SR (4-aminopyridine, 4-AP)|"2 week up titration (10 mg x 1 week, 15 mg x 1 week)~12 weeks stable dose (20 mg)~1 week down titration (15 mg x 3 days, 10 mg x 4 days)"
5814385|NCT00053391|Biological|recombinant CD40-ligand|
5814386|NCT00053391|Biological|therapeutic autologous dendritic cells|
5814387|NCT00053378|Drug|paricalcitol injection (Zemplar)|
5814388|NCT00053378|Behavioral|Effects on calcium regulation|
5814389|NCT00053378|Behavioral|Administration of elemental Ca during hypocalcemic ICU pts.|
5814390|NCT00053365|Drug|irofulven|Given IV
5814391|NCT00053352|Procedure|conventional surgery|
5814392|NCT00053352|Drug|cisplatin|Given IV
5814393|NCT00053352|Drug|etoposide|Given IV
5814394|NCT00053352|Biological|bleomycin sulfate|Given IV
5814395|NCT00053352|Other|laboratory biomarker analysis|Correlative studies
5814396|NCT00053339|Drug|tamoxifen|
5814397|NCT00053339|Drug|trastuzumab|
5814398|NCT00053326|Drug|fenretinide|Given orally
5814399|NCT00053326|Other|pharmacological study|Optional correlative studies
5814400|NCT00053300|Drug|thalidomide|oral thalidomide daily beginning 3-4 weeks after completion of induction chemotherapy. Treatment continues for 1 year in the absence of disease progression or unacceptable toxicity
5814401|NCT00053300|Procedure|adjuvant therapy|Patients receive oral thalidomide daily beginning 3-4 weeks after completion of induction chemotherapy. Treatment continues for 1 year in the absence of disease progression or unacceptable toxicity.
5814402|NCT00053287|Drug|carboplatin|Carboplatin IV over 24 hours on days 1-5
5814403|NCT00053287|Drug|fludarabine phosphate|Fludarabine IV over 5-10 minutes on days 1-5.
5814404|NCT00053287|Drug|thalidomide|Oral thalidomide daily beginning within days 1-3 and continuing in the absence of disease progression or unacceptable toxicity.
5814405|NCT00053287|Drug|topotecan hydrochloride|Topotecan IV continuously over 72 hours.
5814406|NCT00053261|Procedure|management of therapy complications|
5814407|NCT00053248|Drug|arsenic trioxide|
5814408|NCT00053248|Drug|imatinib mesylate|
5814409|NCT00053235|Genetic|Comparative Genomic Hybridization|Correlative studies
5814410|NCT00053235|Other|Laboratory Biomarker Analysis|Correlative studies
5814411|NCT00053235|Genetic|Polymerase Chain Reaction|Correlative studies
5814412|NCT00053222|Drug|arsenic trioxide|
5814413|NCT00053209|Drug|gemcitabine hydrochloride|
5814414|NCT00053209|Drug|pemetrexed disodium|
5814415|NCT00053196|Biological|anti-thymocyte globulin|2.5mg/kg/day IV infusion over 6 hrs x 4 doses Days -4 to -1 (for MUD and 9/10 related donor transplants only)
5814416|NCT00053196|Biological|G-CSF|5 ug/kg/day subQ injection Day 7 until ANC> 1000/uL for 3 consec days
5814417|NCT00053196|Drug|busulfan|0.8mg/kg IV infusion over 2 hrs q 6 hrs x 8 doses Days -4 thru -3
5814418|NCT00053196|Drug|fludarabine phosphate|30 mg/sq m/day IVBP over 30 min Days -7 thru -3
5814419|NCT00053196|Drug|methotrexate|5 mg/sq m/day IV infusion Days 1, 3, & 6 for HLA-identical donor transplants and Days 1, 3, 6, & 11 for MUD & 9/10 related donor transplants
5814420|NCT00053196|Drug|mycophenolate mofetil|15mg/kg PO bid Day -2 to Day 60, then taper as tolerated (for MUD and 9/10 related donor transplants only)
5814421|NCT00053196|Drug|tacrolimus|target serum level is 5-10 ng/mL. Start with 0.03mg/kg PO bid Day -1 to Day 90, then taper thru Day 150 for HLA identical donor transplants and Day -1 to Day 180 then taper for MUD and 9/10 related donor transplants
5814422|NCT00053196|Procedure|allogeneic cell transplantation|2,000,000-8,000,000 CD34+ cells total via infusion Days 0 and 1
5814423|NCT00053196|Drug|allopurinol|300 mg/day PO Days -8 thru -1
5814424|NCT00053183|Procedure|conventional surgery|
5814425|NCT00053183|Radiation|brachytherapy|
5814426|NCT00053183|Radiation|radiation therapy|
5814427|NCT00053157|Biological|sargramostim|
5814428|NCT00053144|Drug|cytarabine|
5814429|NCT00053144|Drug|irinotecan hydrochloride|
5814430|NCT00053131|Biological|filgrastim|
5814431|NCT00053131|Biological|sargramostim|
5814432|NCT00053131|Drug|cytarabine|
5814433|NCT00053131|Drug|mitoxantrone hydrochloride|
5814434|NCT00053118|Biological|filgrastim|IV
5814435|NCT00053118|Drug|carboplatin|IV
5814436|NCT00053118|Drug|etoposide|IV
5814437|NCT00053118|Procedure|bone marrow ablation with stem cell support|IV
5814438|NCT00053118|Procedure|peripheral blood stem cell transplantation|IV
5814439|NCT00053105|Drug|cisplatin|
5814440|NCT00053105|Drug|cytarabine|
5814441|NCT00053105|Drug|methylprednisolone|
5814442|NCT00053105|Drug|pixantrone dimaleate|
5814443|NCT00053092|Biological|rituximab|
5814444|NCT00053092|Drug|cyclophosphamide|
5814445|NCT00053092|Drug|fludarabine phosphate|
5814446|NCT00053053|Dietary Supplement|Juven|
5814447|NCT00053053|Dietary Supplement|Non-Juven Supplement|
5814448|NCT00053040|Biological|cintredekin besudotox|IL13-PE38QQR is administered intracerebrally by continuous convection enhanced infusion at a starting concentration of 0.25 μg/mL. Infusion duration will be held constant at 96 hours (4 days). The phase I component of this study is to estimate the maximum safe total flow rate and the maximum safe infusion concentration.
5814449|NCT00053040|Procedure|conventional surgery|Conventional surgery is used for tumor resection prior to catheter placement for IL13-PE38QQR infusion.
5814450|NCT00053027|Biological|rituximab|
5814451|NCT00053027|Drug|cladribine|
5814452|NCT00053014|Biological|therapeutic allogeneic lymphocytes|
5814453|NCT00053014|Drug|cyclosporine|
5814454|NCT00053014|Drug|fludarabine|
5814455|NCT00053014|Drug|mycophenolate mofetil|
5814456|NCT00053014|Procedure|peripheral blood stem cell transplantation|
5814457|NCT00053014|Radiation|radiation therapy|
5814458|NCT00053001|Biological|epoetin alfa|
5814459|NCT00053001|Drug|thalidomide|
5814460|NCT00041275|Drug|megestrol acetate|
5814461|NCT00004078|Drug|irinotecan hydrochloride|Given IV
5814462|NCT00003830|Procedure|conventional surgery|Sentinel node resection immediately followed by axillary dissection.
5814463|NCT00003830|Procedure|Sentinel node resection followed by node examination|Sentinel node resection followed by node examination then axillary dissection if positive sentinel node. No axillary dissection for negative sentinel node.
5814464|NCT00052962|Procedure|Cytoreductive surgery|"Patients will undergo a laparotomy, surgical incision in the abdomen to assess the peritoneal cavity with cytoreductive surgery or tumor debulking, to reduce tumor size.~Drug: Post operative chemotherapy: systemic oxaliplatin 85 mg/m^2 on day 1 only, leucovorin 200 mg/M^2/day on day 1, 2, 15, and 16, and infusional 5-flurouracil (5-FU) 800 mg/m^2 on day 8, every other week of every four weeks (two weeks per month) starting 4 to 6 weeks after operation and continuing for four cycles { 16 weeks total}."
5814465|NCT00052962|Procedure|Continuous hyperthermic peritoneal perfusion (HIPEC/CHPP)|"Patients will undergo a laparotomy, surgical incision in the abdomen to assess the peritoneal cavity with cytoreductive surgery or tumor debulking, to reduce tumor size.~Followed by continuous hyperthermic peritoneal perfusion (HIPEC) with 250 mg/m^2 cisplatin. Post operative dwell chemotherapy given once between post op day 7 and 12: 5-fluororacil (5-FU) 800 mg/m^2 and paclitaxel 125 mg/m^2.~Drug: Post operative chemotherapy: systemic oxaliplatin 85 mg/m^2 on day 1 only, leucovorin 200 mg/M^2/day on day 1, 2, 15, and 16, and infusional 5-flurouracil (5-FU) 800 mg/m^2 on day 8, every other week of every four weeks (two weeks per month) starting 4 to 6 weeks after operation and continuing for four cycles { 16 weeks total}."
5814466|NCT00052949|Drug|imatinib mesylate|Given orally
5814467|NCT00052949|Other|laboratory biomarker analysis|Correlative studies
5814468|NCT00052936|Biological|filgrastim|
5814469|NCT00052936|Biological|rituximab|
5814470|NCT00052936|Drug|CHOP regimen|
5814471|NCT00052936|Drug|cyclophosphamide|
5814472|NCT00052936|Drug|doxorubicin hydrochloride|
5814473|NCT00052936|Drug|prednisone|
5814474|NCT00052936|Drug|vincristine sulfate|
5814475|NCT00052936|Radiation|radiation therapy|
5814476|NCT00052923|Biological|filgrastim|
5814477|NCT00052923|Biological|rituximab|
5814478|NCT00052923|Drug|carmustine|
5814479|NCT00052923|Drug|cyclophosphamide|
5814480|NCT00052923|Drug|etoposide|
5814481|NCT00052923|Procedure|peripheral blood stem cell transplantation|
5814482|NCT00052923|Radiation|radiation therapy|
5814483|NCT00052910|Drug|cisplatin|Given IV
5814484|NCT00052910|Drug|epirubicin hydrochloride|Given IV
5814485|NCT00052910|Drug|fluorouracil|Given IV
5814486|NCT00052910|Drug|leucovorin calcium|Given IV
5814487|NCT00052910|Radiation|radiation therapy|Given 5 days a week for 5 weeks
5814488|NCT00052897|Biological|HspE7|
5814489|NCT00052884|Biological|filgrastim|
5814490|NCT00052884|Drug|amifostine trihydrate|
5814492|NCT00052884|Procedure|bone marrow ablation with stem cell support|
5814493|NCT00052884|Procedure|peripheral blood stem cell transplantation|
5814494|NCT00052845|Drug|docetaxel|70 mg/sq m IV infusion over 1 hour Day 2 of ea cycle
5814495|NCT00052845|Drug|estramustine phosphate sodium|280 mg PO tid Days 1-5 of ea cycle
5814496|NCT00052845|Drug|exisulind|Two 125 mg capsules PO bid Days 1-21 of ea cycle
5814497|NCT00052832|Dietary Supplement|doxercalciferol|
5814498|NCT00052780|Drug|O6-benzylguanine|Given IV
5814499|NCT00052780|Drug|temozolomide|Given PO
5814500|NCT00052780|Biological|filgrastim|Given SC or IV
5814501|NCT00052780|Other|pharmacological study|Correlative studies
5814502|NCT00052780|Other|laboratory biomarker analysis|Correlative studies
5814503|NCT00052754|Drug|gefitinib|
5814504|NCT00052728|Drug|tamoxifen citrate|
5814505|NCT00052728|Drug|tipifarnib|
5814506|NCT00052715|Drug|poly ICLC|
5814507|NCT00052689|Drug|bortezomib|Given IV
5814508|NCT00052689|Drug|gemcitabine hydrochloride|Given IV
5814509|NCT00052676|Drug|patent blue V dye|
5814510|NCT00052676|Procedure|radionuclide imaging|
5814511|NCT00052676|Procedure|sentinel lymph node biopsy|
5814512|NCT00052676|Radiation|technetium Tc 99m sulfur colloid|
5814513|NCT00052637|Drug|hexaminolevulinate|
5814514|NCT00052637|Procedure|biopsy|
5814515|NCT00052637|Procedure|cystoscopy|
5814516|NCT00052624|Biological|transferrin-CRM107|
5814517|NCT00052611|Drug|Celecoxib|
5814518|NCT00052598|Biological|therapeutic allogeneic lymphocytes|Given IV
5814519|NCT00052598|Biological|aldesleukin|Given SC
5814520|NCT00052598|Other|laboratory biomarker analysis|Correlative studies
5814521|NCT00052598|Other|flow cytometry|Correlative studies
5814522|NCT00052585|Drug|irinotecan hydrochloride|Given IV
5814523|NCT00052585|Drug|gefitinib|Given orally
5814524|NCT00052585|Drug|leucovorin calcium|Given IV
5814525|NCT00052585|Drug|fluorouracil|Given IV
5814526|NCT00052572|Drug|ixabepilone|
5814527|NCT00052559|Biological|bevacizumab|Given IV
5814528|NCT00052559|Drug|fluorouracil|Given IV
5814529|NCT00052559|Radiation|external beam radiation therapy|Undergo external beam radiation therapy
5814530|NCT00052559|Procedure|therapeutic conventional surgery|Undergo surgery
5814531|NCT00052559|Other|laboratory biomarker analysis|Correlative studies
5814532|NCT00052520|Biological|therapeutic allogeneic lymphocytes|Given IV
5814533|NCT00052520|Biological|aldesleukin|Given SC
5814534|NCT00052520|Procedure|peripheral blood stem cell transplantation|Undergo transplantation
5814535|NCT00052520|Procedure|allogeneic bone marrow transplantation|Undergo transplantation
5814536|NCT00052520|Other|laboratory biomarker analysis|Correlative studies
5814537|NCT00052520|Genetic|gene expression analysis|Correlative studies
5814538|NCT00052520|Other|immunologic technique|Correlative studies
5814539|NCT00052520|Other|flow cytometry|Correlative studies
5814540|NCT00052520|Genetic|polymerase chain reaction|Correlative studies
5814541|NCT00052520|Genetic|cytogenetic analysis|Correlative studies
5814542|NCT00052520|Other|staining method|Correlative studies
5814543|NCT00052507|Drug|bortezomib|
5814544|NCT00052494|Drug|cisplatin|
5814545|NCT00052494|Drug|imatinib mesylate|
5814546|NCT00052494|Drug|irinotecan hydrochloride|
5814547|NCT00052481|Procedure|quality-of-life assessment|
5814548|NCT00052468|Drug|TCG|
5814549|NCT00052468|Drug|TC|
5814550|NCT00052455|Drug|lomustine|
5814551|NCT00052455|Drug|procarbazine hydrochloride|
5814552|NCT00052455|Drug|temozolomide|
5814553|NCT00052455|Drug|vincristine sulfate|
5814554|NCT00052442|Drug|pralatrexate|
5814555|NCT00052429|Drug|cisplatin|
5814556|NCT00052429|Drug|fluorouracil|
5814557|NCT00052429|Procedure|adjuvant therapy|
5814558|NCT00052429|Radiation|radiation therapy|
5814559|NCT00052416|Drug|thalidomide|
5814560|NCT00052403|Drug|monoclonal antibody anti-anb3 integrin|
5814561|NCT00052403|Procedure|anti-cytokine therapy|
5814562|NCT00052403|Procedure|antiangiogenesis therapy|
5814563|NCT00052403|Procedure|antibody therapy|
5814564|NCT00052403|Procedure|biological response modifier therapy|
5814565|NCT00052403|Procedure|growth factor antagonist therapy|
5814566|NCT00052403|Procedure|monoclonal antibody therapy|
5814567|NCT00052390|Biological|bevacizumab|
5814568|NCT00052390|Drug|doxorubicin hydrochloride|
5814569|NCT00052377|Biological|aldesleukin|Given SC
5814570|NCT00052377|Biological|recombinant interleukin-12|Given SC
5814571|NCT00052377|Other|laboratory biomarker analysis|Correlative studies
5814572|NCT00052364|Drug|oxaliplatin|Given IV
5814573|NCT00052364|Other|laboratory biomarker analysis|Correlative studies
5814574|NCT00052351|Biological|recombinant fowlpox-CEA(6D)/TRICOM vaccine|
5814575|NCT00052351|Biological|recombinant vaccinia-CEA(6D)-TRICOM vaccine|
5814576|NCT00052351|Biological|sargramostim|
5814577|NCT00052351|Drug|cyclophosphamide|
5814578|NCT00052351|Drug|doxorubicin hydrochloride|
5814579|NCT00052351|Drug|paclitaxel|
5814580|NCT00052351|Radiation|radiation therapy|
5814581|NCT00052338|Drug|gemcitabine hydrochloride|Given IV
5814582|NCT00052338|Drug|carboplatin|Given IV
5814583|NCT00052338|Drug|bortezomib|Given IV
5814584|NCT00052338|Other|laboratory biomarker analysis|Correlative studies
5814585|NCT00052325|Dietary Supplement|mistletoe extract|
5814586|NCT00052312|Drug|cisplatin|
5814587|NCT00052312|Drug|doxorubicin hydrochloride|
5814588|NCT00052312|Drug|paclitaxel|
5814589|NCT00052299|Drug|cytarabine|
5814590|NCT00052299|Drug|etoposide|
5814591|NCT00052299|Drug|gemtuzumab ozogamicin|
5814593|NCT00052299|Drug|mitoxantrone hydrochloride|
5814594|NCT00052286|Drug|modafinil|
5814595|NCT00052273|Drug|capecitabine|
5814596|NCT00052273|Drug|enzastaurin hydrochloride|
5814597|NCT00052221|Biological|Epoetin alfa|
5814598|NCT00052221|Other|Placebo|
5814599|NCT00052208|Drug|gefitinib|Given PO
5814600|NCT00052208|Radiation|radiation therapy|Undergo radiation therapy
5814601|NCT00052208|Other|laboratory biomarker analysis|Correlative studies
5814602|NCT00052195|Biological|SRL-172|5 doses of 0.1mL vaccine or placebo given intradermally over 12-months
5814603|NCT00052182|Biological|EP HIV-1090|
5814604|NCT00052169|Drug|ZD1839 in combination with docetaxel|Docetaxel given as 75 mg/m2 IV every 3 weeks combined with ZD1839 (IRESSA) 250 mg orally daily until disease progression or withdrawal criteria are met.
5814605|NCT00049712|Biological|etaracizumab|
5814606|NCT00049699|Drug|laromustine|
5814607|NCT00049686|Drug|laromustine|
5814608|NCT00049673|Drug|prednisone|Given orally
5814609|NCT00049673|Drug|thalidomide|Given orally
5814610|NCT00049660|Drug|capecitabine|
5814611|NCT00049660|Drug|vinorelbine tartrate|
5814612|NCT00049634|Drug|busulfan|
5814613|NCT00049634|Drug|cyclophosphamide|
5814614|NCT00049634|Drug|cyclosporine|
5814615|NCT00049634|Drug|methotrexate|
5814616|NCT00049634|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5814617|NCT00049608|Dietary Supplement|mistletoe extract|
5814618|NCT00049608|Drug|gemcitabine hydrochloride|
5814619|NCT00049595|Biological|bleomycin sulfate|
5814620|NCT00049595|Biological|filgrastim|
5814621|NCT00049595|Biological|pegfilgrastim|
5814622|NCT00049595|Drug|ABVD regimen|
5814623|NCT00049595|Drug|BEACOPP regimen|
5814624|NCT00049595|Drug|cyclophosphamide|
5814625|NCT00049595|Drug|dacarbazine|
5814626|NCT00049595|Drug|doxorubicin hydrochloride|
5814627|NCT00049595|Drug|etoposide|
5814628|NCT00049595|Drug|prednisone|
5814629|NCT00049595|Drug|procarbazine hydrochloride|
5814630|NCT00049595|Drug|vinblastine sulfate|
5814631|NCT00049595|Drug|vincristine sulfate|
5814632|NCT00049582|Drug|decitabine|Given IV
5814633|NCT00049582|Other|laboratory biomarker analysis|Correlative studies
5814634|NCT00049582|Other|pharmacological study|Correlative studies
5814635|NCT00049569|Drug|cytarabine|Given IT
5814636|NCT00049569|Drug|methotrexate|Given IT
5814637|NCT00049569|Drug|vincristine sulfate|Given IV
5814638|NCT00049569|Drug|prednisone|Given PO
5814639|NCT00049569|Drug|pegaspargase|Given IM
5814640|NCT00049569|Drug|doxorubicin hydrochloride|Given IV
5814641|NCT00049569|Drug|imatinib mesylate|Given PO
5814642|NCT00049569|Drug|cyclophosphamide|Given IV
5814643|NCT00049569|Drug|etoposide|Given IV
5814644|NCT00049569|Biological|filgrastim|Given SC
5814645|NCT00049569|Drug|leucovorin calcium|Given IV
5814646|NCT00049569|Drug|asparaginase|Given IM
5814647|NCT00049569|Drug|therapeutic hydrocortisone|Given IT
5814648|NCT00049556|Drug|gefitinib|
5814649|NCT00049556|Other|immunohistochemistry staining method|
5814650|NCT00049556|Other|surface-enhanced laser desorption/ionization-time of flight mass spectrometry|
5814651|NCT00049556|Procedure|biopsy|
5814652|NCT00049556|Procedure|sentinel lymph node biopsy|
5814653|NCT00049543|Drug|gefitinib|Given PO
5814654|NCT00049543|Other|placebo|Given PO
5814655|NCT00049543|Other|laboratory biomarker analysis|Correlative studies
5814656|NCT00049530|Biological|PEG-interferon alfa-2b|Patients receive PEG-interferon alfa-2b subcutaneously (SC) once weekly. Treatment continues until basic fibroblast growth factor level is suppressed to normal or until a maximum weekly dose is reached. If there is disease progression, patients then discontinue treatment. If there is no disease progression, patients receive PEG-interferon alfa-2b SC weekly for up to 1 year in the absence of disease progression or unacceptable toxicity.
5814657|NCT00049517|Biological|sargramostim|Given IV or as an injection
5814658|NCT00049517|Drug|busulfan|Given IV
5814659|NCT00049517|Drug|cyclophosphamide|Given IV
5814660|NCT00049517|Drug|cytarabine|Given as a continuous infusion
5814661|NCT00049517|Drug|gemtuzumab ozogamicin (GO)|Given IV
5814662|NCT00049517|Drug|Daunorubicin|Given intravenously daily for 3 days at a dose of either 45 or 90 mg/m2.
5814663|NCT00049517|Procedure|Autologous HCT|Autologous hematopoietic cell transplantation
5814664|NCT00049517|Procedure|Allogeneic HCT|Allogeneic hematopoietic cell transplantation
5814665|NCT00049504|Drug|cyclophosphamide|Given IV
5814666|NCT00049504|Drug|fludarabine phosphate|Given IV
5814667|NCT00049504|Drug|tacrolimus|Given IV or orally
5814668|NCT00049504|Drug|mycophenolate mofetil|Given orally
5814669|NCT00049504|Genetic|polymerase chain reaction|Correlative studies
5814670|NCT00049504|Genetic|fluorescence in situ hybridization|Correlative studies
5814671|NCT00049504|Genetic|polymorphism analysis|Correlative studies
5814672|NCT00049504|Genetic|gene expression analysis|Correlative studies
5814673|NCT00049504|Radiation|total-body irradiation|Undergo total-body irradiation
5814674|NCT00049504|Procedure|allogeneic bone marrow transplantation|Undergo haploidentical hematopoietic bone marrow transplantation
5814675|NCT00049504|Procedure|allogeneic hematopoietic stem cell transplantation|Undergo haploidentical hematopoietic bone marrow transplantation
5814676|NCT00049465|Procedure|fatigue assessment and management|
5814677|NCT00049465|Procedure|management of therapy complications|
5814678|NCT00049465|Procedure|psychosocial assessment and care|
5814679|NCT00049452|Drug|zoledronic acid|
5814680|NCT00049439|Biological|filgrastim|filgrastim (G-CSF) subcutaneously on days 5-21 and 28-42. Treatment repeats every 6 weeks for 2 courses in the absence of disease progression or unacceptable toxicity.
5814681|NCT00049439|Drug|cyclophosphamide|Oral cyclophosphamide on days 22-26. Treatment repeats every 6 weeks for 2 courses in the absence of disease progression or unacceptable toxicity.
5814682|NCT00049439|Drug|etoposide|Oral etoposide on days 1-3. Treatment repeats every 6 weeks for 2 courses in the absence of disease progression or unacceptable toxicity.
5814683|NCT00049439|Drug|lomustine|Oral lomustine on day 1 (course 1 only). Treatment repeats every 6 weeks for 2 courses in the absence of disease progression or unacceptable toxicity.
5814684|NCT00049439|Drug|procarbazine hydrochloride|Oral procarbazine on days 22-26. Treatment repeats every 6 weeks for 2 courses in the absence of disease progression or unacceptable toxicity.
5814685|NCT00049413|Biological|rituximab|
5814686|NCT00049413|Drug|cyclophosphamide|
5814687|NCT00049413|Drug|pentostatin|
5814688|NCT00049400|Drug|BMS-247550|BMS-247550 as a 3-hour infusion on Day 1 of a three-week cycle
5814689|NCT00049387|Drug|tipifarnib|Given PO
5814690|NCT00049387|Drug|temozolomide|Given PO
5814691|NCT00049387|Radiation|radiation therapy|Undergo partial brain radiation therapy
5814692|NCT00049374|Biological|oblimersen sodium|
5814693|NCT00049374|Drug|dexamethasone|
5814694|NCT00049374|Drug|thalidomide|
5814695|NCT00049361|Drug|temozolomide|
5814696|NCT00049361|Drug|thalidomide|
5814697|NCT00049361|Radiation|radiation therapy|
5814698|NCT00049348|Biological|epoetin alfa|
5814699|NCT00049348|Biological|filgrastim|
5814700|NCT00049348|Drug|cisplatin|
5814701|NCT00049348|Drug|fluorouracil|
5814702|NCT00049348|Drug|gemcitabine hydrochloride|
5814703|NCT00049348|Procedure|adjuvant therapy|
5814704|NCT00049348|Procedure|conventional surgery|
5814705|NCT00049348|Procedure|neoadjuvant therapy|
5814706|NCT00049348|Radiation|radiation therapy|
5814707|NCT00049335|Drug|capecitabine|1,000 mg/m^2/dose (2,000 mg/m^2/day) BID, PO, on Days 1-14 of 21 day cycle
5814708|NCT00049322|Biological|bevacizumab|"Given IV, 10mg/kg evey two weeks starting 1 week prior to the first chemoembolization.~Patients crossed over to the Bevacizumab arm will receive Bevacizumab after week 14 at the same dose."
5814709|NCT00049309|Dietary Supplement|dietary intervention|
5814710|NCT00049309|Dietary Supplement|flaxseed|
5814711|NCT00049296|Drug|docetaxel|"Patients receive docetaxel IV over 30 minutes once weekly. Courses repeat every 12 weeks in the absence of disease progression or unacceptable toxicity.~Cohorts of 3-6 patients receive escalating doses of docetaxel and thalidomide until the maximum tolerated dose (MTD) is determined."
5814712|NCT00049296|Drug|thalidomide|"Patients receive oral thalidomide twice daily. Courses repeat every 12 weeks in the absence of disease progression or unacceptable toxicity.~Cohorts of 3-6 patients receive escalating doses of docetaxel and thalidomide until the maximum tolerated dose (MTD) is determined."
5814713|NCT00049283|Drug|erlotinib hydrochloride|Given orally
5814714|NCT00049283|Drug|docetaxel|Given IV
5814715|NCT00049283|Radiation|radiation therapy|Undergo radiotherapy
5814716|NCT00049283|Procedure|therapeutic conventional surgery|Undergo neck dissection
5814717|NCT00049283|Other|laboratory biomarker analysis|Correlative studies
5814718|NCT00049283|Other|pharmacological study|Correlative studies
5814719|NCT00049257|Drug|carboplatin|Administered Day 1 of each cycle. AUC=6.
5814720|NCT00049257|Drug|paclitaxel|administered Days 1, 8, and 15 of each cycle. 100mg/m2
5814721|NCT00049244|Drug|capecitabine|
5814722|NCT00049244|Drug|ixabepilone|
5814723|NCT00049231|Drug|EF5|
5814724|NCT00049231|Other|immunohistochemistry staining method|
5814725|NCT00049231|Procedure|biopsy|
5814726|NCT00049218|Biological|Autologous dendritic cell-adenovirus p53 vaccine|
5814727|NCT00049218|Drug|Carboplatin|
5814728|NCT00049218|Drug|Etoposide|
5814729|NCT00049192|Biological|oblimersen sodium|Given IV
5814730|NCT00049192|Drug|imatinib mesylate|Given PO
5814731|NCT00049192|Other|laboratory biomarker analysis|Correlative studies
5814732|NCT00049179|Drug|cytarabine|ind and consol: 200 mg/m2/d continuous IV days 1-7
5814733|NCT00049179|Drug|gemtuzumab ozogamicin|ind and consol: 6 mg/m2 IV over 2 hrs day 1, 4mg/m2 IV over 2 hrs day 8
5814734|NCT00049166|Drug|erlotinib hydrochloride|Given orally
5814735|NCT00049166|Drug|cisplatin|Given IV
5814736|NCT00049166|Radiation|intensity-modulated radiation therapy|Undergo intensity modulated radiation therapy
5814737|NCT00049166|Other|laboratory biomarker analysis|Correlative studies
5814738|NCT00049140|Drug|EF5|
5814739|NCT00049140|Other|bioluminescence|
5814740|NCT00049140|Other|flow cytometry|
5814741|NCT00049140|Other|immunohistochemistry staining method|
5814742|NCT00049140|Procedure|biopsy|
5814743|NCT00049127|Drug|Imatinib Mesylate|Given PO
5814744|NCT00049127|Other|Laboratory Biomarker Analysis|Optional correlative studies
5814745|NCT00049127|Other|Pharmacological Study|Optional correlative studies
5814746|NCT00049114|Drug|doxorubicin hydrochloride|
5814747|NCT00049114|Drug|cyclophosphamide|Given IV
5814748|NCT00049114|Drug|tipifarnib|Given orally
5814749|NCT00049114|Biological|filgrastim|Given subcutaneously
5814750|NCT00049114|Procedure|therapeutic conventional surgery|Undergo complete resection
5814751|NCT00049114|Other|laboratory biomarker analysis|Correlative studies
5814752|NCT00049101|Drug|erlotinib hydrochloride|
5814753|NCT00049101|Drug|fluorouracil|
5814754|NCT00049101|Drug|leucovorin calcium|
5814755|NCT00049101|Drug|oxaliplatin|
5814756|NCT00049088|Drug|docetaxel|Given IV
5814757|NCT00049088|Biological|bevacizumab|Given IV
5814758|NCT00049088|Other|laboratory biomarker analysis|Correlative studies
5814759|NCT00049088|Other|pharmacological study|Correlative studies
5814760|NCT00049075|Drug|fludarabine phosphate|
5814761|NCT00049062|Drug|anastrozole|
5814762|NCT00049062|Drug|gefitinib|
5814763|NCT00049036|Biological|rituximab|Given IV
5814764|NCT00049036|Drug|etoposide|Given IV
5814765|NCT00049036|Drug|doxorubicin hydrochloride|Given IV
5814766|NCT00049036|Drug|vincristine sulfate|Given IV
5814767|NCT00049036|Drug|prednisone|Given orally
5814768|NCT00049036|Drug|cyclophosphamide|Given IV
5814769|NCT00049036|Other|laboratory biomarker analysis|Correlative studies
5814770|NCT00049023|Radiation|90Y-DOTA-tyr3-OCTREOTIDE|
5814771|NCT00049010|Genetic|comparative genomic hybridization|
5814772|NCT00049010|Genetic|cytogenetic analysis|
5814773|NCT00049010|Genetic|fluorescence in situ hybridization|
5814774|NCT00049010|Other|immunohistochemistry staining method|
5814775|NCT00048997|Radiation|Radiation therapy|PCI is given to the whole brain in a dose of 2 Gy per fraction, 5 days per week, for 3 weeks for a total dose of 30 Gy.
5814776|NCT00048997|Other|Observation|
5814777|NCT00048984|Other|laboratory biomarker analysis|Correlative studies
5814778|NCT00048971|Genetic|mutation analysis|
5814779|NCT00048971|Genetic|polymorphic microsatellite marker analysis|
5814780|NCT00048958|Genetic|cytogenetic analysis|
5814781|NCT00047385|Device|low-dose helical computed tomography|A LDCT is a computerized tomography image with low-dose technique without contrast. The scan is done from the neck to the diaphragm in one breath-hold.
5814782|NCT00047385|Device|chest radiography|The chest x-ray in this study was a single posterior-anterior film done with the participant upright.
5814783|NCT00047346|Drug|erlotinib hydrochloride|Given PO
5814784|NCT00047346|Other|pharmacological study|Correlative studies
5814785|NCT00047346|Other|laboratory biomarker analysis|Correlative studies
5814786|NCT00047333|Drug|erlotinib hydrochloride|Given PO
5814787|NCT00047333|Other|laboratory biomarker analysis|Correlative studies
5814788|NCT00047333|Other|pharmacological study|Correlative studies
5814789|NCT00047320|Drug|carboplatin|Given IV
5814790|NCT00047320|Drug|etoposide|Given IV
5814791|NCT00047320|Drug|ifosfamide|Given IV
5814792|NCT00047320|Drug|thiotepa|Given IV
5814793|NCT00047320|Procedure|adjuvant therapy|
5814794|NCT00047320|Procedure|conventional surgery|
5814795|NCT00047320|Procedure|neoadjuvant therapy|
5814796|NCT00047320|Procedure|peripheral blood stem cell transplantation|
5814797|NCT00047320|Radiation|radiation therapy|craniospinal irradiation
5814798|NCT00047307|Drug|alvocidib|Given IV
5814799|NCT00047307|Drug|gemcitabine hydrochloride|Given IV
5814800|NCT00047307|Radiation|3-dimensional conformal radiation therapy|Undergo 3-dimensional conformal radiation therapy
5814801|NCT00047307|Other|laboratory biomarker analysis|Correlative studies
5814802|NCT00047294|Drug|celecoxib|
5814803|NCT00047294|Drug|temozolomide|
5814804|NCT00047294|Drug|thalidomide|
5814805|NCT00047294|Procedure|adjuvant therapy|
5814806|NCT00047281|Drug|celecoxib|
5814807|NCT00047281|Drug|cyclophosphamide|
5814808|NCT00047281|Drug|etoposide|
5814809|NCT00047281|Drug|thalidomide|
5814810|NCT00047268|Drug|cytarabine|
5814811|NCT00047268|Drug|mercaptopurine|
5814812|NCT00047268|Other|laboratory biomarker analysis|
5814813|NCT00047268|Procedure|allogeneic bone marrow transplantation|
5814814|NCT00047268|Procedure|biopsy|
5814815|NCT00047268|Procedure|peripheral blood stem cell transplantation|
5814816|NCT00047255|Biological|trastuzumab|"Cycle 1: Day 1: Herceptin (H) 4 mg/kg loading dose admin by IV over 90 mins, Day 2: Docetaxel (T) 75 mg/m2 by IV over 1 hour followed by carboplatin (C) at target AUC=6 mg/mL/min admin by IV over 30-60 mins, Day 8: (H) 2mg/kg admin by IV over 30 mins, Day 15: 2mg/kg admin by IV over 30 mins.~Subsequent cycles: Day 1: (T) 75mg/m2 as 1 hour IV followed by (C) at target AUC=6 mg/mL/min admin by IV 30-60 mins every 3 weeks followed by (H) 2 mg/kg IV over 30 mins, Day 8: (H) 2 mg/kg admin by IV over 30 mins, Day 15: (H) 2 mg/kg admin by IV over 30 mins.~Last cycle: Day 1: (T) 75mg/m2 as 1 hour IV followed by (C) at target AUC=6 mg/mL/min admin by IV 30-60 mins every 3 weeks followed by (H) 2 mg/kg IV over 30 mins, Day 8: (H) 2 mg/kg admin by IV over 30 mins, Day 15: (H) 2 mg/kg admin by IV over 30 mins, Day 22: (H) 6 mg/kg admin by IV over 30 mins."
5814817|NCT00047255|Drug|carboplatin|"Cycle 1: Day 1: Herceptin (H) 4 mg/kg loading dose admin by IV over 90 mins, Day 2: Docetaxel (T) 75 mg/m2 by IV over 1 hour followed by carboplatin (C) at target AUC=6 mg/mL/min admin by IV over 30-60 mins, Day 8: (H) 2mg/kg admin by IV over 30 mins, Day 15: 2mg/kg admin by IV over 30 mins.~Subsequent cycles: Day 1: (T) 75mg/m2 as 1 hour IV followed by (C) at target AUC=6 mg/mL/min admin by IV 30-60 mins every 3 weeks followed by (H) 2 mg/kg IV over 30 mins, Day 8: (H) 2 mg/kg admin by IV over 30 mins, Day 15: (H) 2 mg/kg admin by IV over 30 mins.~Last cycle: Day 1: (T) 75mg/m2 as 1 hour IV followed by (C) at target AUC=6 mg/mL/min admin by IV 30-60 mins every 3 weeks followed by (H) 2 mg/kg IV over 30 mins, Day 8: (H) 2 mg/kg admin by IV over 30 mins, Day 15: (H) 2 mg/kg admin by IV over 30 mins, Day 22: (H) 6 mg/kg admin by IV over 30 mins."
5814818|NCT00047255|Drug|docetaxel|"Cycle 1: Day 1: Herceptin (H) 4 mg/kg loading dose administered by IV infusion over 90 minutes, Day 2: Docetaxel (T) 100 mg/m2 by IV infusion over 30 minutes, Day 8: (H) 2mg/kg administered by IV infusion over 30 minutes, Day 15: 2mg/kg administered by IV infusion over 30 minutes.~Subsequent cycles: Day 1: (T) 100mg/m2 as 1 hour IV infusion given every 3 weeks, followed by (H) 2 mg/kg IV infusion over 30 minutes, Day 8: (H) 2 mg/kg administered by IV infusion over 30 minutes, Day 15: (H) 2 mg/kg administered by IV infusion over 30 minutes.~Last cycle: Day 1: (T) 100mg/m2 as 1 hour IV infusion followed by (H) 2 mg/kg IV infusion over 30 minutes, Day 8: (H) 2 mg/kg administered by IV infusion over 30 minutes, Day 15: (H) 2 mg/kg administered by IV infusion over 30 minutes, Day 22: (H) 6 mg/kg administered by IV infusion over 30 minutes."
5814952|NCT00045513|Drug|fludarabine phosphate|
5814953|NCT00045500|Drug|7-hydroxystaurosporine|
5814954|NCT00045500|Drug|prednisone|
5814955|NCT00045487|Drug|OSI-774|OSI-774 is an orally active, potent, selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase.
5814956|NCT00045474|Procedure|adjuvant therapy|
5814957|NCT00045474|Radiation|iodine I 125|
5814958|NCT00045461|Drug|carboplatin|
5814959|NCT00045461|Drug|ifosfamide|
5814819|NCT00047255|Biological|trastuxumab|"Cycle 1: Day 1: Herceptin (H) 4 mg/kg loading dose administered by IV infusion over 90 minutes, Day 2: Docetaxel (T) 100 mg/m2 by IV infusion over 30 minutes, Day 8: (H) 2mg/kg administered by IV infusion over 30 minutes, Day 15: 2mg/kg administered by IV infusion over 30 minutes.~Subsequent cycles: Day 1: (T) 100mg/m2 as 1 hour IV infusion given every 3 weeks, followed by (H) 2 mg/kg IV infusion over 30 minutes, Day 8: (H) 2 mg/kg administered by IV infusion over 30 minutes, Day 15: (H) 2 mg/kg administered by IV infusion over 30 minutes.~Last cycle: Day 1: (T) 100mg/m2 as 1 hour IV infusion followed by (H) 2 mg/kg IV infusion over 30 minutes, Day 8: (H) 2 mg/kg administered by IV infusion over 30 minutes, Day 15: (H) 2 mg/kg administered by IV infusion over 30 minutes, Day 22: (H) 6 mg/kg administered by IV infusion over 30 minutes."
5814820|NCT00047255|Drug|Docetaxel|"Cycle 1: Day 1: Herceptin (H) 4 mg/kg loading dose admin by IV over 90 mins, Day 2: Docetaxel (T) 75 mg/m2 by IV over 1 hour followed by carboplatin (C) at target AUC=6 mg/mL/min admin by IV over 30-60 mins, Day 8: (H) 2mg/kg admin by IV over 30 mins, Day 15: 2mg/kg admin by IV over 30 mins.~Subsequent cycles: Day 1: (T) 75mg/m2 as 1 hour IV followed by (C) at target AUC=6 mg/mL/min admin by IV 30-60 mins every 3 weeks followed by (H) 2 mg/kg IV over 30 mins, Day 8: (H) 2 mg/kg admin by IV over 30 mins, Day 15: (H) 2 mg/kg admin by IV over 30 mins.~Last cycle: Day 1: (T) 75mg/m2 as 1 hour IV followed by (C) at target AUC=6 mg/mL/min admin by IV 30-60 mins every 3 weeks followed by (H) 2 mg/kg IV over 30 mins, Day 8: (H) 2 mg/kg admin by IV over 30 mins, Day 15: (H) 2 mg/kg admin by IV over 30 mins, Day 22: (H) 6 mg/kg admin by IV over 30 mins."
5814821|NCT00047242|Drug|7-hydroxystaurosporine|
5814822|NCT00047242|Drug|irinotecan hydrochloride|
5814823|NCT00047229|Biological|oblimersen sodium|
5814824|NCT00047229|Drug|doxorubicin hydrochloride|
5814825|NCT00047216|Drug|tipifarnib|
5814826|NCT00047203|Drug|alvocidib|Given IV
5814827|NCT00047190|Drug|tipifarnib|Given PO
5814828|NCT00047190|Other|laboratory biomarker analysis|Correlative studies
5814829|NCT00047177|Drug|Oxaliplatin|
5814830|NCT00047164|Biological|ipilimumab|
5814831|NCT00047138|Biological|dactinomycin|
5814832|NCT00047138|Drug|carboplatin|
5814833|NCT00047138|Drug|cyclophosphamide|
5814834|NCT00047138|Drug|doxorubicin hydrochloride|
5814835|NCT00047138|Drug|etoposide|
5814836|NCT00047138|Drug|vincristine sulfate|
5814837|NCT00047138|Procedure|adjuvant therapy|
5814838|NCT00047138|Procedure|conventional surgery|
5814839|NCT00047138|Procedure|neoadjuvant therapy|
5814840|NCT00047138|Radiation|radiation therapy|
5814841|NCT00047125|Radiation|radiation therapy|
5814842|NCT00047112|Drug|cisplatin|
5814843|NCT00047112|Drug|fluorouracil|
5814844|NCT00047112|Procedure|conventional surgery|
5814845|NCT00047112|Procedure|neoadjuvant therapy|
5814846|NCT00047112|Radiation|radiation therapy|
5814847|NCT00047099|Drug|cyclophosphamide|
5814848|NCT00047099|Drug|docetaxel|
5814849|NCT00047099|Drug|epirubicin hydrochloride|
5814850|NCT00047099|Drug|fluorouracil|
5814851|NCT00047099|Drug|goserelin acetate|
5814852|NCT00047099|Drug|tamoxifen citrate|
5814853|NCT00047099|Procedure|adjuvant therapy|
5814854|NCT00047099|Radiation|radiation therapy|
5814855|NCT00047073|Drug|Rapamycin|"Phase 1: Initial dose 6mg on day 1 and then 2mg each day for 5-7 days before surgery. No dosing during surgery recovery. After recorvery 6mg loading dose on day 1 then 2mg each day. Cycle is every 4 weeks.~Dose escalation: Level 2: 15mg load/5mg/day, Level 3: 30mg load/10mg/day, Level 4: 45mg load/15mg/day.~Phase 2: Will utilize dose established in phase I. Dosing schedule will remain the same."
5814856|NCT00047073|Procedure|Surgery|Surgical resection.
5814857|NCT00047073|Procedure|Supportive Care|"Corticosteroids should be used in smallest dose to control symptoms of cerebral edema and mass effect.~Anti-seizure medications should be used as indicated. Febrile neutropenia may be managed according to local institution's infectious disease guidelines.~If neurosurgical management is required for reasons not due to tumor progression, these procedures must be documented."
5814858|NCT00047060|Other|A matched peripheral donor stem cells|A matched peripheral donor stem cells
5814859|NCT00047060|Drug|cyclosporine|cyclosporine
5814860|NCT00047060|Drug|fludarabine|fludarabine
5814861|NCT00047060|Drug|Campath|Campath
5814862|NCT00047047|Drug|gemcitabine hydrochloride|Given IV
5814863|NCT00047047|Drug|tanespimycin|Given IV
5814864|NCT00047047|Drug|cisplatin|Given IV
5814865|NCT00047047|Other|laboratory biomarker analysis|Correlative studies
5814866|NCT00047034|Drug|eribulin mesylate|Given IV
5814867|NCT00047034|Other|pharmacological study|Correlative studies
5814868|NCT00047034|Other|laboratory biomarker analysis|Correlative studies
5814869|NCT00047021|Biological|sargramostim|Sargramostim (GM-CSF) subcutaneously beginning on day 14 and continuing until blood counts recover.
5814870|NCT00047021|Drug|cytarabine|high-dose cytarabine IV over 1 hour on days 1-5
5814871|NCT00047021|Drug|mitoxantrone hydrochloride|high-dose mitoxantrone IV over 15-30 minutes on day 5.
5814872|NCT00047008|Drug|cisplatin|100 mg/m^2 intravenously on days 1, 22
5814873|NCT00047008|Radiation|Standard fractionation RT|Radiation will be delivered in 2 Gy per fraction, five fractions a week. The primary tumor and clinically/radiologically involved nodes will receive 70 Gy in 7 weeks and uninvolved nodes will receive 50 Gy in 5 weeks. The anterior lower neck field will be treated with 2 Gy per fraction at 3-cm depth to a total dose of 50 Gy.
5814874|NCT00047008|Radiation|Accelerated fractionation radiation therapy|Radiation to the initial target volume encompassing the gross and subclinical disease sites will be delivered in 1.8 Gy per fraction, five fractions a week to 54 Gy in 30 fractions over 6 weeks. At 32.4 Gy/18 Fx (i.e., latter part of week 4), the boost volume covering gross tumor and clinically/radiologically involved nodes will receive boost irradiation of 1.5 Gy/Fx as second daily fraction (at least 6 h interval) for a total of 12 treatment days (18 Gy total). The primary tumor and clinically/radiologically involved nodes will receive 72 Gy in 42 fractions over 6 weeks and uninvolved nodes will receive 54 Gy in 6 weeks. Clinically/radiologically negative posterior neck should receive a minimum dose of 50.4 Gy at 3 cm. The anterior lower neck field will be treated with 1.8 Gy per fraction at 3-cm depth to a total dose of 50.4 Gy in 28 fractions in 5.6 weeks.
5814875|NCT00047008|Procedure|Conventional surgery for select patients|"Surgical removal (salvage resection) of the primary tumor should be performed if biopsy-proven cancer remains more than three months after completion of therapy. The nature of the surgical resection should be dictated by the extent of tumor at the initial evaluation. The operation should be conducted using accepted criteria for primary surgical treatment of the cancer.~A planned neck dissection for patients with multiple neck nodes or with lymph nodes exceeding 3 cm in diameter (N2a, N2b, N3) is mandatory, regardless of the clinical and/or radiographic response. A neck dissection is required for patients with N1 disease if a palpable or worrisome radiographic abnormality persists in the neck six weeks after completion of therapy. Surgery should be performed within 2 weeks once the decision for neck dissection is made."
5814876|NCT00046995|Drug|carboplatin|
5814877|NCT00046995|Drug|fluorouracil|
5814878|NCT00046995|Drug|leucovorin calcium|
5814879|NCT00046995|Procedure|adjuvant therapy|
5814880|NCT00046969|Biological|epoetin beta|
5814881|NCT00046969|Drug|cisplatin|
5814882|NCT00046969|Radiation|brachytherapy|
5814883|NCT00046969|Radiation|radiation therapy|
5814884|NCT00046943|Drug|atrasentan hydrochloride|
5814885|NCT00046930|Biological|filgrastim|250 μg/m2/day by either intravenous or subcutaneous injection starting day 12, provided marrow aplasia is achieved, through recovery of absolute neutrophil count (ANC) to > 500 cells/μl, sustained for 3 consecutive days. The dose may be rounded to the nearest vial size.
5814886|NCT00046930|Biological|sargramostim|5 μg/kg/day by either intravenous or subcutaneous injection starting day 12, provided marrow aplasia is achieved, through recovery of absolute neutrophil count (ANC) to > 500 cells/μl, sustained for 3 consecutive days. The dose may be rounded to the nearest vial size.
5814887|NCT00046930|Drug|cytarabine|100 mg/m²/day by continuous intravenous infusion for 7 days (days 1-7).
5814888|NCT00046930|Drug|daunorubicin hydrochloride|45 mg/m²/day by 10 - 15 minute intravenous infusion for 3 days (days 1, 2, and 3).
5814889|NCT00046930|Drug|zosuquidar trihydrochloride|"Zosuquidar 550 mg/day by continuous intravenous infusion through a central venous catheter over approximately 6 hours on days 1, 2, and 3.~The infusion will begin approximately one hour prior to daunorubicin on days 1, 2 and 3."
5814890|NCT00046930|Drug|Placebo|"Placebo 550 mg/day by continuous intravenous infusion through a central venous catheter over approximately 6 hours on days 1, 2, and 3.~The infusion will begin approximately one hour prior to daunorubicin on days 1, 2 and 3. Placebo consisted of a 1:1000 dilution of Infuvite, appropriately colored."
5814891|NCT00046917|Drug|alvocidib|Given IV
5814892|NCT00046917|Drug|irinotecan hydrochloride|Given IV
5814893|NCT00046917|Drug|cisplatin|Given IV
5814894|NCT00046904|Biological|etanercept|
5814895|NCT00046891|Drug|Ginkgo Biloba|Patients will take 120 mg per day (60 mg BID)
5814896|NCT00046891|Other|Placebo|Patients will take 1 tablet BID
5814897|NCT00046865|Procedure|acupressure therapy|
5814898|NCT00046865|Procedure|management of therapy complications|
5814899|NCT00046865|Procedure|nausea and vomiting therapy|
5814900|NCT00046852|Biological|filgrastim|
5814901|NCT00046852|Biological|pneumococcal polyvalent vaccine|
5814902|NCT00046852|Biological|therapeutic autologous lymphocytes|
5814903|NCT00046852|Biological|therapeutic tumor infiltrating lymphocytes|
5814904|NCT00046852|Drug|carmustine|
5814905|NCT00046852|Drug|cyclophosphamide|
5814906|NCT00046852|Drug|melphalan|
5814907|NCT00046852|Procedure|bone marrow ablation with stem cell support|
5814908|NCT00046852|Procedure|peripheral blood stem cell transplantation|
5814909|NCT00046839|Drug|celecoxib|
5814910|NCT00046839|Radiation|radiation therapy|
5814911|NCT00046826|Drug|docetaxel|
5814912|NCT00046826|Drug|estramustine phosphate sodium|
5814913|NCT00046826|Drug|thalidomide|
5814914|NCT00045747|Drug|7-hydroxystaurosporine|
5814915|NCT00045747|Drug|fluorouracil|
5814916|NCT00045734|Drug|imatinib mesylate|Given orally
5814917|NCT00045734|Other|laboratory biomarker analysis|Correlative studies
5814918|NCT00045734|Other|pharmacological study|Correlative studies
5814919|NCT00045721|Drug|O6-benzylguanine|
5814920|NCT00045721|Drug|polifeprosan 20 with carmustine implant|
5814921|NCT00045721|Procedure|adjuvant therapy|
5814922|NCT00045721|Procedure|conventional surgery|
5814923|NCT00045721|Procedure|neoadjuvant therapy|
5814924|NCT00045708|Drug|ixabepilone|Given IV
5814925|NCT00045708|Other|pharmacological study|Correlative studies
5814926|NCT00045708|Drug|Anticonvulsant|Drugs that induce hepatic Metabolic enzymes
5814927|NCT00045695|Drug|bortezomib|PS-341 bolus intravenous injection twice weekly* for 2 out of every 3 weeks
5814928|NCT00045682|Drug|Paclitaxel Poliglumex|Given IV
5814929|NCT00045669|Drug|imatinib mesylate|
5814930|NCT00045630|Drug|carboplatin|
5814931|NCT00045630|Drug|gemcitabine|
5814932|NCT00045630|Drug|paclitaxel|
5814933|NCT00045630|Procedure|surgery|
5814934|NCT00045617|Biological|monoclonal antibody 11D10 anti-idiotype vaccine|
5814935|NCT00045617|Biological|monoclonal antibody GD2 anti-idiotype vaccine|
5814936|NCT00045617|Drug|cisplatin|
5814937|NCT00045617|Drug|etoposide|
5814938|NCT00045617|Radiation|radiation therapy|
5814939|NCT00045604|Drug|cisplatin|
5814940|NCT00045604|Drug|imatinib mesylate|
5814941|NCT00045604|Drug|irinotecan hydrochloride|
5814942|NCT00045591|Drug|celecoxib|100 mg PO bid
5814943|NCT00045591|Drug|Celecoxib|400 mg PO bid
5814944|NCT00045565|Drug|arsenic trioxide|Given IV
5814945|NCT00045565|Radiation|radiation therapy|Undergo radiation therapy
5814946|NCT00045539|Drug|leucovorin calcium|
5814947|NCT00045539|Drug|methotrexate|
5814948|NCT00045539|Drug|thiotepa|
5814949|NCT00045526|Drug|erlotinib hydrochloride|Given PO
5814950|NCT00045526|Other|laboratory biomarker analysis|Correlative studies
5814951|NCT00045513|Drug|7-hydroxystaurosporine|
5814960|NCT00045461|Procedure|hyperthermia treatment|
5814961|NCT00045448|Drug|alvocidib|
5814962|NCT00045448|Drug|docetaxel|
5814963|NCT00045435|Procedure|nonmyeloablative allogeneic hematopoietic stem cell transplantation|Undergo nonmyeloablative allogeneic PBSC transplant
5814964|NCT00045435|Drug|fludarabine phosphate|Given IV
5814965|NCT00045435|Radiation|total-body irradiation|Undergo TBI
5814966|NCT00045435|Drug|cyclosporine|Given PO
5814967|NCT00045435|Drug|mycophenolate mofetil|Given PO
5814968|NCT00045435|Procedure|peripheral blood stem cell transplantation|Undergo nonmyeloablative allogeneic PBSC transplant
5814969|NCT00045422|Biological|recombinant interferon alfa|
5814970|NCT00045422|Drug|imatinib mesylate|
5814971|NCT00045396|Drug|tipifarnib|Given orally
5814972|NCT00045370|Biological|recombinant interferon alfa|
5814973|NCT00045370|Drug|temsirolimus|
5814974|NCT00045331|Genetic|proteomic profiling|
5814975|NCT00045318|Drug|exatecan mesylate|
5814976|NCT00045305|Drug|Cyclosporine|Immunosuppressant
5814977|NCT00045305|Drug|Methotrexate|Antimetabolite
5814978|NCT00045305|Drug|Photopheresis|Psoralens
5814979|NCT00045305|Drug|Mycofenolate mofetil|an antibiotic with immunosuppressamt properties isolated from Penicillium spp
5814980|NCT00045305|Drug|Pentostatin|Purine analogue
5814981|NCT00045305|Procedure|allogeneic bone marrow|Unmanipulated allogeneic bone marrow
5814982|NCT00045305|Procedure|peripheral blood stem cell|G-CSF mobilized peripheral blood stem cell
5814983|NCT00045305|Radiation|Total body irradiation|a total of 600 cGy given in 3 200 cGy fractionated doses
5814984|NCT00045292|Drug|acyclovir|
5814985|NCT00045292|Drug|acyclovir sodium|
5814986|NCT00045292|Drug|valacyclovir|
5814987|NCT00045279|Biological|PEG-interferon alfa-2b|
5814988|NCT00045266|Biological|ziv-aflibercept|
5814989|NCT00045227|Biological|recombinant fowlpox-prostate specific antigen vaccine|
5814990|NCT00045227|Biological|recombinant vaccinia prostate-specific antigen vaccine|
5814991|NCT00045227|Biological|recombinant vaccinia-B7.1 vaccine|
5814992|NCT00045227|Biological|sargramostim|
5814993|NCT00045227|Drug|docetaxel|
5814994|NCT00045201|Drug|Erlotinib Hydrochloride|Given orally
5814995|NCT00045201|Drug|Irinotecan Hydrochloride|Given IV
5814996|NCT00045188|Drug|imatinib mesylate|Given PO
5814997|NCT00045188|Other|laboratory biomarker analysis|Optional correlative studies
5814998|NCT00045175|Drug|7-hydroxystaurosporine|
5814999|NCT00045175|Drug|topotecan hydrochloride|
5815000|NCT00045162|Drug|cisplatin|"Arm 1: 60 mg/m2 IV (over 30-60 min) on Day 1, Q 4 weeks x 4 Cycles~Arm 2: 80 mg/m2 IV (over 30-60 min) on Day 1, Q 4 weeks x 4 Cycles"
5815001|NCT00045162|Drug|etoposide|100 mg/m2 IV (over 30-60 min) on Days 1 , 2 & 3. Q 3 weeks x 4 Cycles
5815002|NCT00045162|Drug|irinotecan hydrochloride|60 mg/m2 IV (over 90 min)on Days 1, 8 & 15. Q 4 weeks x 4 Cycles
5815003|NCT00045136|Drug|melphalan|
5815004|NCT00045136|Procedure|peripheral blood stem cell transplantation|
5815005|NCT00045136|Radiation|holmium Ho 166 DOTMP|
5815006|NCT00045110|Drug|erlotinib hydrochloride|given orally
5815007|NCT00045110|Other|laboratory biomarker analysis|correlative studies
5815008|NCT00045110|Other|pharmacological study|correlative studies
5815009|NCT00045097|Drug|ixabepilone|
5815010|NCT00045045|Procedure|positron emission tomography|
5815011|NCT00045045|Radiation|fludeoxyglucose F 18|
5815012|NCT00045032|Drug|Herceptin|Herceptin will be given as a loading dose of 8 milligrams per kilogram (mg/kg) via intravenous (IV) infusion on Day 1, followed by a maintenance dose of 6 mg/kg via IV infusion 3 weeks later and thereafter every 3 weeks.
5815013|NCT00045032|Drug|Herceptin|Herceptin will be given as a loading dose of 8 mg/kg via IV infusion on Day 1, followed by a maintenance dose of 6 mg/kg via IV infusion 3 weeks later and thereafter every 3 weeks.
5815014|NCT00045019|Other|quality-of-life assessment|QLQ-C30 SAT32
5815015|NCT00045006|Drug|vorinostat|
5815016|NCT00044993|Biological|Ad5CMV-p53 gene|
5815017|NCT00044993|Drug|docetaxel|
5815018|NCT00044993|Drug|doxorubicin hydrochloride|
5815019|NCT00044993|Procedure|conventional surgery|
5815020|NCT00044993|Procedure|neoadjuvant therapy|
5815021|NCT00044980|Procedure|nutritional support|
5815022|NCT00044980|Procedure|quality-of-life assessment|
5815023|NCT00044967|Genetic|microsatellite instability analysis|
5815024|NCT00044954|Biological|therapeutic allogeneic lymphocytes|
5815025|NCT00044954|Drug|cyclosporine|
5815026|NCT00044954|Drug|fludarabine phosphate|
5815027|NCT00044954|Drug|mycophenolate mofetil|
5815028|NCT00044954|Procedure|allogeneic bone marrow transplantation|
5815029|NCT00044954|Procedure|peripheral blood stem cell transplantation|
5815030|NCT00044954|Radiation|radiation therapy|
5815031|NCT00043147|Drug|beclomethasone dipropionate|
5815032|NCT00043147|Drug|methylprednisolone|
5815033|NCT00043147|Drug|prednisone|
5815034|NCT00043134|Drug|decitabine|
5815035|NCT00043121|Drug|oxaliplatin|Given IV
5815036|NCT00043121|Drug|leucovorin calcium|Given IV
5815037|NCT00043121|Drug|fluorouracil|Given IV
5815038|NCT00043121|Drug|capecitabine|Given orally
5815039|NCT00043121|Other|pharmacological study|Correlative studies
5815040|NCT00043095|Drug|gemcitabine hydrochloride|
5815041|NCT00043095|Drug|ixabepilone|
5815042|NCT00043082|Drug|carboplatin|intravenous q 4 weeks
5815043|NCT00043082|Drug|pegylated liposomal doxorubicin hydrochloride|intravenous q 4 weeks
5815044|NCT00043069|Dietary Supplement|calcium carbonate|
5815045|NCT00043069|Dietary Supplement|cholecalciferol|
5815046|NCT00043069|Drug|Estrogen Antagonists|
5815047|NCT00043069|Drug|risedronate sodium|
5815048|NCT00043069|Other|placebo|
5815049|NCT00043043|Drug|celecoxib|
5815050|NCT00043030|Procedure|psychosocial assessment and care|
5815051|NCT00043017|Procedure|MRI/MRS|Serial MRI studies evaluated for prognostic properties related to therapeutic response.
5815052|NCT00043017|Radiation|gadopentetate dimeglumine|Imaging agent used for contrast enhancement in each of the MRIs.
5815053|NCT00043004|Biological|bevacizumab|
5815054|NCT00043004|Drug|FOLFOX regimen|
5815055|NCT00043004|Drug|fluorouracil|
5815056|NCT00043004|Drug|leucovorin calcium|
5815057|NCT00043004|Drug|oxaliplatin|
5815058|NCT00043004|Procedure|conventional surgery|
5815059|NCT00043004|Procedure|radiofrequency ablation|
5815060|NCT00042991|Drug|gefitinib|Given orally
5815061|NCT00042991|Radiation|radiation therapy|Undergo standard brain irradiation
5815062|NCT00042991|Other|pharmacological study|Correlative studies
5815063|NCT00042991|Other|laboratory biomarker analysis|Correlative studies
5815064|NCT00042978|Biological|oblimersen sodium|Given IV
5815065|NCT00042978|Drug|carboplatin|Given IV
5815066|NCT00042978|Drug|etoposide|Given IV
5815067|NCT00042965|Drug|capecitabine|
5815068|NCT00042965|Drug|gemcitabine hydrochloride|
5815069|NCT00042952|Drug|imatinib mesylate|Given orally
5815070|NCT00042952|Procedure|therapeutic conventional surgery|Undergo surgical resection
5815071|NCT00042952|Other|laboratory biomarker analysis|Correlative studies
5815072|NCT00042939|Biological|cetuximab|Patients received cetuximab intravenous infusions, via infusion pump or syringe pump, once a week for 6 weeks.
5815073|NCT00042939|Drug|docetaxel|Docetaxel was administered intravenously over 60 minutes at a dose of 35 mg/m² once a week (days 1, 8, 15, 22) for 4 consecutive weeks followed by 2 weeks rest. Docetaxel was diluted in 100-150 ml of infusion solution.
5815074|NCT00042939|Drug|irinotecan hydrochloride|After the completion of the docetaxel infusion, irinotecan was administered intravenously over 30 minutes at a dose of 50 mg/m² once a week (days 1, 8, 15, 22) for 4 consecutive weeks followed by 2 weeks rest.
5815075|NCT00042926|Other|immunohistochemistry staining method|
5815076|NCT00042926|Procedure|conventional surgery|
5815077|NCT00042926|Procedure|lymphangiography|
5815078|NCT00042926|Procedure|radionuclide imaging|
5815079|NCT00042926|Procedure|sentinel lymph node biopsy|
5815080|NCT00042926|Radiation|technetium Tc 99m sulfur colloid|
5815081|NCT00042913|Biological|epratuzumab|
5815082|NCT00042887|Drug|mitomycin C|
5815083|NCT00042887|Procedure|conventional surgery|
5815084|NCT00042874|Drug|alvocidib|Given IV
5815085|NCT00042874|Drug|irinotecan hydrochloride|Given IV
5815086|NCT00042874|Drug|fluorouracil|Given IV
5815087|NCT00042874|Drug|leucovorin calcium|Given IV
5815088|NCT00042874|Other|laboratory biomarker analysis|Correlative studies
5815089|NCT00042861|Drug|7-hydroxystaurosporine|
5815090|NCT00042861|Drug|fluorouracil|
5815091|NCT00042861|Drug|leucovorin calcium|
5815092|NCT00042848|Drug|modafinil|
5815093|NCT00042835|Drug|cisplatin|Given IV
5815094|NCT00042835|Drug|etoposide|Given IV
5815095|NCT00042835|Drug|erlotinib hydrochloride|Given orally
5815096|NCT00042835|Radiation|radiation therapy|Undergo radiotherapy
5815097|NCT00042835|Drug|docetaxel|Given IV
5815098|NCT00042835|Drug|paclitaxel|Given IV
5815099|NCT00042835|Drug|carboplatin|Given IV
5815100|NCT00042835|Other|laboratory biomarker analysis|Correlative studies
5815101|NCT00042822|Drug|romidepsin|
5815102|NCT00042809|Drug|paclitaxel|Given IV
5815103|NCT00042809|Biological|trastuzumab|Given IV
5815104|NCT00042809|Drug|erlotinib hydrochloride|Given orally
5815105|NCT00042809|Other|laboratory biomarker analysis|Correlative studies
5815106|NCT00042809|Other|pharmacological study|Correlative studies
5815107|NCT00042796|Drug|decitabine|Given IV
5815108|NCT00042796|Other|pharmacological study|Correlative studies
5815109|NCT00042796|Other|laboratory biomarker analysis|Correlative studies
5815110|NCT00042783|Biological|D1/3-MAGE-3-His fusion protein|
5815111|NCT00042783|Biological|SB-AS02B adjuvant|
5815112|NCT00042770|Other|talc|Given intrapleurally
5815113|NCT00042770|Procedure|dyspnea management|No talc
5815114|NCT00042731|Dietary Supplement|Lycopene|Daily administration as outlined in treatment arm(s)
5815115|NCT00042731|Dietary Supplement|Multivitamin|Daily administration as outlined in treatment arm(s)
5815116|NCT00042731|Dietary Supplement|Soy isoflavones|Daily administration as outlined in treatment arm(s)
5815117|NCT00041379|Drug|beta alethine|
5815118|NCT00041340|Drug|imatinib mesylate|Given orally
5815119|NCT00041340|Other|laboratory biomarker analysis|Correlative studies
5815120|NCT00041327|Biological|filgrastim|5 ug/kg/d
5815121|NCT00041327|Biological|recombinant interferon alfa|9 mU subcutaneously per day for one year
5815122|NCT00041327|Drug|Etoposide|50 mg/m2/day continuous 96 hr infusion, days 1-4
5815123|NCT00041327|Drug|cyclophosphamide|750 mg/m2 IV on day 5
5815124|NCT00041327|Drug|doxorubicin hydrochloride|10 mg/m2/day as a continuous 96-hour infusion days 1-4
5815125|NCT00041327|Drug|lamivudine|150 mg bid
5815126|NCT00041327|Drug|prednisone|60 mg/m2 given orally days 1-5
5815127|NCT00041327|Drug|vincristine sulfate|0.4 mg/m2/day as a 96-hour continuous infusion days 1-4
5815128|NCT00041327|Drug|zidovudine|300 mg bid
5815129|NCT00041314|Drug|carboplatin|
5815130|NCT00041314|Drug|exisulind|
5815131|NCT00041314|Drug|gemcitabine hydrochloride|
5815132|NCT00041301|Other|QoL assessment|qol questionnaires
5815133|NCT00041288|Biological|therapeutic allogeneic lymphocytes|
5815134|NCT00041288|Drug|cyclophosphamide|
5815135|NCT00041288|Drug|cyclosporine|
5815136|NCT00041288|Drug|fludarabine phosphate|
5815137|NCT00041288|Drug|methotrexate|
5815138|NCT00041288|Drug|mycophenolate mofetil|
5815140|NCT00041288|Procedure|peripheral blood stem cell transplantation|
5815141|NCT00041288|Radiation|radiation therapy|
5815142|NCT00041262|Drug|cisplatin|
5815143|NCT00041262|Drug|epirubicin hydrochloride|
5815144|NCT00041262|Drug|fluorouracil|
5815145|NCT00041262|Procedure|conventional surgery|
5815146|NCT00041262|Procedure|neoadjuvant therapy|
5815147|NCT00041249|Drug|brostallicin|
5815148|NCT00041236|Drug|exatecan mesylate|
5815149|NCT00041223|Dietary Supplement|IH636 grape seed proanthocyanidin extract|
5815150|NCT00041210|Biological|bleomycin sulfate|
5815151|NCT00041210|Drug|ABVD regimen|
5815152|NCT00041210|Drug|Stanford V regimen|
5815153|NCT00041210|Drug|dacarbazine|
5815154|NCT00041210|Drug|doxorubicin hydrochloride|
5815155|NCT00041210|Drug|etoposide|
5815156|NCT00041210|Drug|mechlorethamine hydrochloride|
5815157|NCT00041210|Drug|prednisone|
5815158|NCT00041210|Drug|vinblastine sulfate|
5815159|NCT00041210|Drug|vincristine sulfate|
5815160|NCT00041210|Radiation|radiation therapy|
5815161|NCT00041197|Drug|imatinib mesylate|Given orally (PO)
5815162|NCT00041197|Other|placebo|Given PO
5815163|NCT00041197|Other|laboratory biomarker analysis|Correlative studies
5815164|NCT00041171|Drug|Hypericum perforatum|
5815165|NCT00041171|Drug|docetaxel|
5815166|NCT00041171|Other|placebo|
5815167|NCT00041132|Biological|filgrastim|5 ug/kg
5815168|NCT00041132|Biological|rituximab|375 mg/m^2 on day 1 of cycles 1-6
5815169|NCT00041132|Drug|cyclophosphamide|300 mg/m^2 on days 2-4 of cycles 1,3,5,7
5815170|NCT00041132|Drug|cytarabine|12 g/m^2 over days 3-4 of cycles 2,4,6,8
5815171|NCT00041132|Drug|dexamethasone|40 mg on days 2-5 and 12-15 of cycles 1,3,5,7
5815172|NCT00041132|Drug|doxorubicin|16.6 mg/m^2/day for days 5-7 of cycles 1,3,5,7
5815173|NCT00041132|Drug|leucovorin|170 mg over days 3-5 of cycles 2,4,6,8
5815174|NCT00041132|Drug|methotrexate|1000 mg/m^2 over days 2-3 of cycles 2,4,6,8
5815175|NCT00041132|Drug|vincristine|1.4 mg/m^2 on days 5 and 12 of cycles 1,3,5,7
5815176|NCT00041119|Drug|AC regimen|Given IV
5815177|NCT00041119|Drug|cyclophosphamide|Given IV
5815178|NCT00041119|Drug|doxorubicin hydrochloride|Given IV
5815179|NCT00041119|Drug|paclitaxel|Given IV
5815180|NCT00041106|Drug|gemcitabine hydrochloride|Given IV
5815181|NCT00041106|Drug|cisplatin|Given IV
5815182|NCT00041106|Drug|gefitinib|Given PO
5815183|NCT00041106|Other|laboratory biomarker analysis|Correlative studies
5815184|NCT00041093|Drug|Docetaxel|Given IV
5815185|NCT00041080|Drug|tamoxifen citrate|Given orally
5815186|NCT00041080|Drug|thalidomide|Given orally
5815187|NCT00041080|Other|laboratory biomarker analysis|Correlative studies
5815188|NCT00041067|Biological|filgrastim|
5815189|NCT00041067|Biological|trastuzumab|
5815190|NCT00041067|Drug|docetaxel|
5815191|NCT00041067|Drug|vinorelbine|
5815192|NCT00041054|Drug|carboplatin|
5815193|NCT00041054|Drug|etoposide|
5815194|NCT00041054|Drug|exisulind|
5815195|NCT00041041|Drug|imatinib mesylate|Given PO
5815196|NCT00041041|Other|laboratory biomarker analysis|Correlative studies
5815197|NCT00041028|Drug|EF5|
5815198|NCT00041028|Other|flow cytometry|
5815199|NCT00041028|Other|immunohistochemistry staining method|
5815200|NCT00041015|Drug|cisplatin|
5815201|NCT00041015|Drug|etoposide|
5815202|NCT00041015|Drug|topotecan hydrochloride|
5815203|NCT00040989|Drug|BAY 56-3722|
5815204|NCT00040989|Procedure|enzyme inhibitor therapy|
5815205|NCT00040950|Biological|rituximab|
5815206|NCT00040950|Drug|agatolimod sodium|
5815207|NCT00040937|Biological|filgrastim|PBSC collection: 10 mcg/kg SQ days 1-10
5815208|NCT00040937|Biological|sargramostim|"PBSC collection: 500 mcg/m2 SQ day 1 through last apheresis~1st and 2nd trans: 500 mcg SC or IV days 6-WBC recovery"
5815209|NCT00040937|Drug|cyclophosphamide|PBSC collection: 1 mg/m2 IV over 45-60 mins day 0
5815210|NCT00040937|Drug|dexamethasone|40 mg/d PO days 1-4, 9-12, 17-20
5815211|NCT00040937|Drug|melphalan|"st trans: 140 mg/m2 IV over 20 mins day -1~nd trans: 200mg/m2 IV over 20 mins day -1"
5815212|NCT00040937|Drug|prednisone|maint: 50 mg/d PO every other day until progression
5815213|NCT00040937|Drug|thalidomide|ind: 50 mg increased by 50 mg every week to max 400 mg PO qhs for 35 days maint: 50 mg/d increased by 50 mg every week to 200 mg PO daily until progression
5815214|NCT00040937|Procedure|peripheral blood stem cell transplantation|2-4 x 10^6/kg IV day 0
5815215|NCT00040911|Procedure|electroacupuncture therapy|
5815216|NCT00040911|Procedure|sham intervention|Undergo electroacupuncture therapy to sham points
5815217|NCT00040911|Procedure|quality-of-life assessment|Ancillary studies
5815218|NCT00040898|Dietary Supplement|Sho-saiko-to|
5815219|NCT00040885|Biological|infliximab|
5815220|NCT00040885|Drug|docetaxel|
5815221|NCT00040885|Other|placebo|
5815222|NCT00040872|Biological|filgrastim|
5815223|NCT00040872|Biological|monoclonal antibody 3F8|
5815224|NCT00040872|Biological|sargramostim|
5815225|NCT00040872|Drug|carboplatin|
5815226|NCT00040872|Drug|cisplatin|
5815227|NCT00040872|Drug|cyclophosphamide|
5815228|NCT00040872|Drug|doxorubicin hydrochloride|
5815229|NCT00040872|Drug|etoposide|
5815230|NCT00040872|Drug|isotretinoin|
5815231|NCT00040872|Drug|thiotepa|
5815232|NCT00040872|Drug|topotecan hydrochloride|
5815233|NCT00040872|Drug|vincristine sulfate|
5815234|NCT00040872|Procedure|autologous bone marrow transplantation|
5815235|NCT00040872|Procedure|bone marrow ablation with stem cell support|
5815236|NCT00040872|Procedure|conventional surgery|
5815237|NCT00040872|Procedure|drug resistance inhibition treatment|
5815238|NCT00040872|Procedure|peripheral blood stem cell transplantation|
5815239|NCT00040872|Procedure|syngeneic bone marrow transplantation|
5815240|NCT00040872|Radiation|radiation therapy|
5815241|NCT00040859|Drug|capecitabine|
5815242|NCT00040859|Drug|oxaliplatin|
5815243|NCT00040846|Biological|alemtuzumab|Given IV
5815244|NCT00040846|Drug|fludarabine phosphate|Given IV
5815245|NCT00040846|Radiation|total-body irradiation|Undergo TBI
5815246|NCT00040846|Procedure|allogeneic hematopoietic stem cell transplantation|Undergo allogeneic HSCT
5815247|NCT00040846|Procedure|peripheral blood stem cell transplantation|Undergo allogeneic peripheral blood stem cell transplantation
5815248|NCT00040846|Drug|mycophenolate mofetil|Given PO
5815249|NCT00040846|Drug|cyclosporine|Given IV or PO
5815250|NCT00040833|Procedure|complementary or alternative medicine procedure|
5815251|NCT00040833|Procedure|pain therapy|
5815252|NCT00040807|Drug|docetaxel|
5815253|NCT00040807|Drug|irinotecan hydrochloride|
5815254|NCT00040794|Drug|paclitaxel|Given IV
5815255|NCT00040794|Drug|carboplatin|Given IV
5815256|NCT00040794|Drug|gefitinib|Given PO
5815257|NCT00040794|Radiation|radiation therapy|Undergo radiotherapy
5815258|NCT00040794|Other|laboratory biomarker analysis|Optional correlative studies
5815259|NCT00040781|Drug|gefitinib|Given orally
5815260|NCT00040781|Other|pharmacological study|Correlative studies
5815261|NCT00040781|Other|laboratory biomarker analysis|Correlative studies
5815262|NCT00040768|Drug|bortezomib|Given IV
5815263|NCT00040755|Drug|rebimastat|Given orally
5815264|NCT00040755|Other|laboratory biomarker analysis|Correlative studies
5815265|NCT00040742|Dietary Supplement|ginger|Given orally
5815266|NCT00040742|Other|placebo|Given orally
5815267|NCT00040690|Biological|filgrastim|
5815268|NCT00040690|Drug|cyclophosphamide|
5815269|NCT00040690|Drug|cytarabine|
5815270|NCT00040690|Drug|doxorubicin hydrochloride|
5815271|NCT00040690|Drug|etoposide|
5815272|NCT00040690|Drug|ifosfamide|
5815273|NCT00040690|Drug|leucovorin calcium|
5815274|NCT00040690|Drug|methotrexate|
5815275|NCT00040690|Drug|vincristine sulfate|
5815276|NCT00040690|Radiation|radiation therapy|
5815277|NCT00039611|Drug|FOLFOX regimen|
5815278|NCT00039611|Drug|fluorouracil|
5815279|NCT00039611|Drug|leucovorin calcium|
5815280|NCT00039611|Drug|oxaliplatin|
5815281|NCT00039585|Drug|imatinib mesylate|
5815282|NCT00039572|Drug|boronophenylalanine-fructose complex|
5815283|NCT00039559|Other|Early detection|CA125 is measured in blood and the longitudinal results interpreted with a statistical algorithm to determine if there has been a significant increase from baseline.
5815284|NCT00039546|Drug|cyclophosphamide|
5815285|NCT00039546|Drug|epirubicin hydrochloride|
5815286|NCT00039546|Drug|gemcitabine hydrochloride|
5815287|NCT00039546|Drug|paclitaxel|
5815288|NCT00039546|Procedure|adjuvant therapy|
5815289|NCT00039520|Drug|docetaxel|
5815290|NCT00039520|Drug|sulindac|
5815291|NCT00039507|Procedure|conventional surgery|
5815292|NCT00039507|Procedure|radiofrequency ablation|
5815293|NCT00039494|Drug|erlotinib hydrochloride|Given orally
5815294|NCT00039494|Radiation|3-dimensional conformal radiation therapy|
5815295|NCT00039494|Drug|temozolomide|Given orally
5815296|NCT00039481|Biological|oblimersen sodium|Given IV
5815297|NCT00039481|Drug|dexrazoxane hydrochloride|Given IV
5815298|NCT00039481|Drug|doxorubicin hydrochloride|Given IV
5815299|NCT00039481|Drug|cyclophosphamide|Given IV
5815300|NCT00039481|Biological|filgrastim|Given SC
5815301|NCT00039481|Other|laboratory biomarker analysis|Correlative studies
5815302|NCT00039481|Other|pharmacological study|Correlative studies
5815303|NCT00039468|Drug|irinotecan hydrochloride|350 or 700 mg/m2 IV every 3 weeks
5815304|NCT00039468|Drug|thalidomide|400mg/day oral
5815305|NCT00039455|Biological|trastuzumab|Given IV
5815306|NCT00039455|Drug|alvocidib|Given IV
5815307|NCT00039455|Other|laboratory biomarker analysis|Correlative studies
5815308|NCT00039455|Other|pharmacological study|Correlative studies
5815309|NCT00039442|Drug|Capecitabine|Given orally
5815310|NCT00039442|Other|Laboratory Biomarker Analysis|Correlative studies
5815311|NCT00039429|Drug|atrasentan hydrochloride|
5815312|NCT00039416|Drug|imatinib mesylate|Given orally
5815313|NCT00039416|Other|laboratory biomarker analysis|Correlative studies
5815314|NCT00039403|Drug|7-hydroxystaurosporine|Given IV
5815315|NCT00039403|Drug|gemcitabine hydrochloride|Given IV
5815316|NCT00039403|Other|pharmacological study|Correlative studies
5815317|NCT00039403|Other|laboratory biomarker analysis|Correlative studies
5815318|NCT00039390|Drug|capecitabine|Given orally (PO)
5815319|NCT00039390|Drug|gefitinib|Given PO
5815320|NCT00039390|Other|pharmacological study|Correlative studies
5815321|NCT00039390|Other|laboratory biomarker analysis|Correlative studies
5815322|NCT00039377|Drug|imatinib mesylate|Given PO
5815323|NCT00039377|Drug|methotrexate|Given IT and IV
5815324|NCT00039377|Drug|vincristine sulfate|Given IV
5815325|NCT00039377|Drug|leucovorin calcium|Given IV and PO
5815326|NCT00039377|Procedure|peripheral blood stem cell transplantation|Undergo PBSCT
5815327|NCT00039377|Procedure|autologous hematopoietic stem cell transplantation|Undergo autologous PBSCT
5815328|NCT00039377|Procedure|allogeneic hematopoietic stem cell transplantation|Undergo allogeneic PBSCT
5815329|NCT00039377|Radiation|total-body irradiation|Undergo TBI
5815330|NCT00039377|Drug|tacrolimus|Given IV or PO
5815331|NCT00039377|Biological|filgrastim|Given SC
5815332|NCT00039377|Drug|etoposide|Given IV
5815333|NCT00039377|Drug|cyclophosphamide|Given IV
5815334|NCT00039377|Drug|cytarabine|Given IV
5815335|NCT00039377|Other|laboratory biomarker analysis|Correlative studies
5815336|NCT00039364|Drug|imatinib mesylate|
5815337|NCT00039351|Drug|cyclophosphamide|
5815338|NCT00039351|Drug|prednisone|
5815339|NCT00039351|Drug|vincristine sulfate|
5815340|NCT00039351|Radiation|radiation therapy|
5815341|NCT00039338|Procedure|conventional surgery|Radial hysterectomy
5815342|NCT00039338|Procedure|neoadjuvant chemotherapy|Experimental arm: minimal cumulative cisplatin dose of 225 mg/m2. Comparator arm: cumulative cisplatin dose of 200-240 mg/m2.
5815343|NCT00039338|Radiation|brachytherapy|Brachytherapy at the end of external radiation. Minimal total dose (external with or without external boost + brachytherapy) of 75 Gy EQD2 to point A. Overall treatment less than 50 days.
5815344|NCT00039338|Radiation|radiation therapy|Between 45-50 Gy, in fractions of 1.8 to 2 Gy.
5815345|NCT00039338|Drug|cisplatin|Minimal cumulative 225 mg/m2 (experimental arm). Cumulative 200-240 mg/m2 (comparator arm).
5815346|NCT00039325|Biological|dendritic cell-MART-1 peptide vaccine|Subjects will receive MART-1 adenovirus-transduced dendritic cells (DC)at dose of 10^6 (for arm A) or 10^7 (for arms B-E). Subjects will receive a total of three biweekly vaccinations given intradermally. If significant clinical or immunological response (to be defined later) is noted, subjects will be eligible for up to 6 additional monthly vaccine administrations.
5815347|NCT00039312|Other|Papanicolaou test|
5815348|NCT00039312|Other|cytology specimen collection procedure|
5815349|NCT00039312|Procedure|annual screening|
5815350|NCT00039312|Procedure|colposcopic biopsy|
5815351|NCT00039312|Procedure|comparison of screening methods|
5815352|NCT00039299|Biological|therapeutic autologous lymphocytes|
5815353|NCT00039286|Procedure|positron emission tomography|
5815354|NCT00039286|Procedure|radionuclide imaging|
5815355|NCT00039286|Radiation|fludeoxyglucose F 18|
5815356|NCT00039273|Biological|panitumumab|
5815357|NCT00039234|Biological|aldesleukin|
5815358|NCT00039234|Drug|histamine dihydrochloride|
5815359|NCT00039208|Drug|fluorouracil|
5815360|NCT00039208|Drug|irinotecan hydrochloride|
5815361|NCT00039208|Drug|leucovorin calcium|
5815362|NCT00039208|Drug|oxaliplatin|
5815363|NCT00039195|Biological|filgrastim|
5815364|NCT00039195|Biological|rituximab|
5815365|NCT00039195|Drug|carboplatin|
5815366|NCT00039195|Drug|cyclophosphamide|
5815367|NCT00039195|Drug|doxorubicin hydrochloride|
5815368|NCT00039195|Drug|etoposide|
5815369|NCT00039195|Drug|ifosfamide|
5815370|NCT00039195|Drug|prednisone|
5815371|NCT00039195|Drug|vincristine sulfate|
5815372|NCT00039195|Procedure|peripheral blood stem cell transplantation|
5815373|NCT00039195|Radiation|radiation therapy|
5815374|NCT00039182|Drug|erlotinib hydrochloride|Given orally
5815375|NCT00039182|Other|laboratory biomarker analysis|Correlative studies
5815376|NCT00039156|Drug|ortataxel|
5815377|NCT00039130|Biological|filgrastim|5 ug/kg/day sub Q injection day 7 until ANC>5000/ul courses II-VII
5815378|NCT00039130|Biological|rituximab|Day 8 course II 50 mg/sq m IV infusion: d 8 course IV & VI 375mg/sq m IV Day 10 course II: 325 mg/sq m IV infusion Day 12 course II: 375 mg/sq m IV infusion
5815379|NCT00039130|Drug|cyclophosphamide|200 mg/sq m/day IV infusion over 5-15 min days 1-5, courses I, III, V, VII
5815380|NCT00039130|Drug|cytarabine|1 g/sq m/day IV infusion Days 4 & 5, courses II, IV, VI
5815381|NCT00039130|Drug|dexamethasone|10mg/sq m PO or IV Days 1-5 courses II-VII
5815382|NCT00039130|Drug|doxorubicin hydrochloride|25 mg/sq m/day IV infusion Days 4 & 5 courses III,V, VII
5815383|NCT00039130|Drug|etoposide|80 mg/sq m/day IV infusion Days 4 & 5 courses II, IV, VI
5815384|NCT00039130|Drug|ifosfamide|800 mg/sq m/day IV infusion Days 1-5 courses II, IV, VI
5815385|NCT00039130|Drug|leucovorin calcium|25mg/sq m IV infusion over 15 min then 10 mg IV q 6 hrs until serum MTX <10nM, courses II-VII
5815386|NCT00039130|Drug|methotrexate|1.5 g/sq m IV infusion Day 1 courses II-VII
5815387|NCT00039130|Drug|prednisone|60 mg/sq m PO/day Days 1-7 course I
5815388|NCT00039130|Drug|vincristine sulfate|2 mg IV push Day 1 courses II-VII
5815389|NCT00039130|Drug|Allopurinol|300 mg/day PO Days 1-14, course I
5815390|NCT00039117|Biological|oblimersen sodium|Given IV
5815391|NCT00039117|Drug|cytarabine|Given IV
5815392|NCT00039117|Drug|daunorubicin hydrochloride|Given IV
5815393|NCT00039117|Other|laboratory biomarker analysis|Correlative studies
5815394|NCT00039117|Other|pharmacological study|Correlative studies
5815395|NCT00039104|Drug|rebimastat|Given PO
5815396|NCT00039104|Drug|zoledronic acid|Given IV
5815397|NCT00039104|Other|laboratory biomarker analysis|Correlative studies
5815398|NCT00039091|Biological|ipilimumab|Given IV
5815399|NCT00039078|Radiation|yttrium Y 90 glass microspheres|
5815400|NCT00039052|Biological|interleukin-4 PE38KDEL cytotoxin|
5815401|NCT00039039|Drug|carboplatin|
5815402|NCT00039039|Drug|chemotherapy|
5815403|NCT00039039|Drug|cisplatin|
5815404|NCT00039039|Drug|paclitaxel|
5815405|NCT00039039|Radiation|radiation therapy|
5815406|NCT00037037|Biological|MAGE-10.A2|
5815407|NCT00037037|Biological|MART-1 antigen|
5815408|NCT00037037|Biological|NY-ESO-1 peptide vaccine|
5815409|NCT00037037|Biological|sargramostim|
5815410|NCT00037037|Biological|tyrosinase peptide|
5815411|NCT00037024|Procedure|fatigue assessment and management|
5815412|NCT00037024|Procedure|nutritional support|
5815413|NCT00037024|Procedure|physical therapy|
5815414|NCT00037024|Procedure|psychosocial assessment and care|
5815415|NCT00037024|Procedure|quality-of-life assessment|
5815416|NCT00037011|Biological|beta-glucan|
5815417|NCT00037011|Biological|monoclonal antibody 3F8|
5815418|NCT00036998|Procedure|conventional surgery|
5815419|NCT00036998|Procedure|neoadjuvant therapy|
5815420|NCT00036998|Procedure|thermal ablation therapy|
5815421|NCT00036985|Drug|cyclophosphamide|
5815422|NCT00036985|Drug|doxorubicin hydrochloride|
5815423|NCT00036985|Procedure|conventional surgery|
5815424|NCT00036985|Procedure|neoadjuvant therapy|
5815425|NCT00036985|Procedure|thermal ablation therapy|
5815426|NCT00036972|Biological|cintredekin besudotox|
5815427|NCT00036972|Procedure|adjuvant therapy|
5815428|NCT00036972|Procedure|conventional surgery|
5815429|NCT00036972|Procedure|neoadjuvant therapy|
5815430|NCT00036959|Drug|ABT-751|
5815431|NCT00036946|Biological|ziv-aflibercept|
5815432|NCT00036933|Biological|MUC-2-Globo H-KLH conjugate vaccine|
5815433|NCT00036933|Biological|QS21|
5815434|NCT00036894|Drug|lenalidomide|
5815435|NCT00036881|Dietary Supplement|zinc sulfate|
5815436|NCT00036881|Other|placebo|
5815437|NCT00036868|Biological|trastuzumab|
5815438|NCT00036868|Drug|CMF regimen|
5815439|NCT00036868|Drug|cyclophosphamide|
5815440|NCT00036868|Drug|fluorouracil|
5815441|NCT00036868|Drug|methotrexate|
5815442|NCT00036855|Biological|rituximab|Given IV
5815443|NCT00036855|Radiation|indium In 111 ibritumomab tiuxetan|Given IV
5815444|NCT00036855|Radiation|yttrium Y 90 ibritumomab tiuxetan|Given IV
5815445|NCT00036855|Procedure|peripheral blood stem cell transplantation|Undergo PBSC transplantation
5815446|NCT00036855|Biological|filgrastim|Given subcutaneously
5815447|NCT00036855|Other|laboratory biomarker analysis|Correlative studies
5815448|NCT00036842|Drug|arsenic trioxide|
5815449|NCT00036829|Procedure|pain therapy|
5815450|NCT00036816|Biological|MART-1 antigen|
5815451|NCT00036816|Biological|NA17-A antigen|
5815452|NCT00036816|Biological|gp100 antigen|
5815453|NCT00036816|Biological|tyrosinase peptide|
5815454|NCT00036790|Drug|doxorubicin hydrochloride|
5815455|NCT00036790|Drug|motexafin gadolinium|
5815456|NCT00036777|Drug|carboplatin|Given IV
5815457|NCT00036777|Drug|7-hydroxystaurosporine|Given IV
5815458|NCT00036777|Other|pharmacological study|Correlative studies
5815459|NCT00036764|Drug|ixabepilone|Given IV
5815460|NCT00036764|Other|pharmacogenomic studies|Correlative studies
5815461|NCT00036764|Other|laboratory biomarker analysis|Correlative studies
5815462|NCT00036751|Drug|imatinib mesylate|Given orally
5815463|NCT00036751|Other|laboratory biomarker analysis|Correlative studies
5815464|NCT00036738|Drug|Cyclosporine|Given IV or PO
5815465|NCT00036738|Drug|Dasatinib|Given PO
5815466|NCT00036738|Drug|Fludarabine Phosphate|Given IV
5815467|NCT00036738|Drug|Imatinib Mesylate|Given PO
5815468|NCT00036738|Drug|Mycophenolate Mofetil|Given PO
5815469|NCT00036738|Drug|Nilotinib|Given PO
5815470|NCT00036738|Procedure|Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|Undergo nonmyeloablative allogeneic PBSC transplantation
5815471|NCT00036738|Procedure|Peripheral Blood Stem Cell Transplantation|Undergo allogeneic PBSC transplantation
5815472|NCT00036738|Biological|Therapeutic Allogeneic Lymphocytes|Given IV
5815473|NCT00036738|Radiation|Total-Body Irradiation|Undergo TBI
5815474|NCT00036712|Procedure|management of therapy complications|
5815475|NCT00036712|Procedure|pain therapy|
5815476|NCT00036686|Dietary Supplement|Soy protein isolate|Arm I: Patients receive oral soy protein isolate twice daily and oral multivitamins once daily.
5815477|NCT00036686|Other|Placebo|Arm II: Patients receive oral placebo twice daily and oral multivitamins once daily.
5815478|NCT00033748|Biological|monoclonal antibody 11D10 anti-idiotype|2 mg intradermal injection q 14 days for 4 doses, then sub Q monthly for 4 months, following a 6-12 wk rest period after curative hepatic resection
5815479|NCT00033748|Biological|monoclonal antibody 3H1 Alu Gel|2 mg intradermal injection q 14 days for 4 doses, then sub Q monthly for 4 months, following a 6-12 wk rest period after curative hepatic resection
5815480|NCT00033709|Drug|temozolomide|
5815481|NCT00033709|Drug|thalidomide|
5815482|NCT00033696|Biological|filgrastim|
5815483|NCT00033696|Drug|carboplatin|
5815484|NCT00033696|Drug|etoposide|
5815485|NCT00033696|Drug|paclitaxel|
5815486|NCT00033696|Drug|topotecan hydrochloride|
5815487|NCT00033696|Radiation|radiation therapy|
5815488|NCT00033683|Drug|CMF regimen|
5815489|NCT00033683|Drug|cyclophosphamide|
5815490|NCT00033683|Drug|docetaxel|
5815491|NCT00033683|Drug|epirubicin hydrochloride|
5815492|NCT00033683|Drug|fluorouracil|
5815493|NCT00033683|Drug|methotrexate|
5815494|NCT00033683|Drug|tamoxifen citrate|
5815495|NCT00033683|Procedure|adjuvant therapy|
5815496|NCT00033683|Radiation|radiation therapy|
5815497|NCT00033657|Drug|cisplatin|"Days 1 - 35 : Cisplatin 30 mg/m² days 1, 8, 15, 22, 29~Days 63 - 77 : cisplatin 30 mg/m² and irinotecan 65 mg/m² days 1 and 8 of three 3-week cycles"
5815498|NCT00033657|Drug|irinotecan hydrochloride|"Days 1 - 35 : Irinotecan 65 mg/m² days 1, 8, 22, 29~Days 63 - 77 : irinotecan 65 mg/m² days 1 and 8 of three 3-week cycles"
5815499|NCT00033657|Drug|paclitaxel|"Days 1 - 35 : Paclitaxel 50 mg/m² (1 hr) days 1, 8, 15, 22, 29~Days 63 - 77 : paclitaxel 175 mg/m² and cisplatin 75 mg/m² day 1 of three 3-week cycles"
5815500|NCT00033657|Procedure|conventional surgery|The type of resection (lvor-Lewis, Transhiatal, etc.) was left to the discretion of the operating surgeon. One lymph node dissection was required.
5815501|NCT00033657|Radiation|radiation therapy|The total dose to the prescription point was 4500 cGy given in 25 fractions. The patient was treated with one fraction per day with all fields treated per day. 180 cGy was delivered to the isocenter. If the dose to the supraclavicular fossa (SCF) was less than 4500 cGy, a localized photon or electron boost was allowed in order to increase the SCF dose to 4500 cGy, specified at 3 cm depth from the anterior skin surface.
5815502|NCT00033644|Biological|sargramostim|
5815503|NCT00033644|Drug|cisplatin|
5815505|NCT00033644|Drug|doxorubicin hydrochloride|
5815506|NCT00033644|Drug|mitomycin C|
5815507|NCT00033631|Radiation|70.2 Gy 3D-CRT/IMRT|Radiation will be delivered via 3D conformal radiation therapy (3D-CRT) or intensity modulated radiation therapy (IMRT) in 1.8 Gy minimum dose fractions to a total of 70.2 Gy in 39 Fractions. All fields treated once daily, five fractions per week. No more than 2% of the planning target volume and none of the clinical target volume may receive less than 70.2 Gy.
5815508|NCT00033631|Radiation|79.2 Gy 3D-CRT/IMRT|Radiation will be delivered via 3D conformal radiation therapy (3D-CRT) or intensity modulated radiation therapy (IMRT) in 1.8 Gy minimum dose fractions to a total of 79.2 Gy in 44 fractions. All fields treated once daily, five fractions per week. No more than 2% of the planning target volume and none of the clinical target volume may receive less than 79.2 Gy.
5815509|NCT00033618|Drug|ixabepilone|Given IV
5815510|NCT00033618|Other|laboratory biomarker analysis|Correlative studies
5815511|NCT00033605|Drug|octreotide acetate|
5815512|NCT00033605|Other|placebo|
5815513|NCT00033605|Radiation|radiation|
5815514|NCT00033566|Drug|S-3304|
5815515|NCT00033553|Drug|carboplatin|Arm A: AUC=6 IV over 30 min for 2 cycles then AUC=2 IV over 30 min q wk for 7 wks Arm B: AUC=5 IV over 30 min for 2 cycles
5815516|NCT00033553|Drug|gemcitabine hydrochloride|1000 mg/sq m IV over 30 min days 1 & 8 repeat q 21 days for 2 cycles; then 35 mg/sq m IV over 30 min 2X wk for 7 wks
5815517|NCT00033553|Drug|paclitaxel|225 mg/sq m IV over 3 hrs q 21 days for 2 cycles, then 45 mg/sq m IV over 1 hr q wk for 7 wks
5815518|NCT00033553|Radiation|radiation therapy|3-D XRT 7400 cGy total after induction (during cycles 3-9)
5815519|NCT00033540|Drug|capecitabine|650 mg/m^2 twice daily (BID), by mouth (PO) at 12 hour intervals, Days 1-14, every 21 days
5815520|NCT00033540|Drug|gemcitabine hydrochloride|1000 mg/m^2, intravenous (IV) over 100 minutes, Days 1,8, every 21 days
5815521|NCT00033514|Biological|trastuzumab|Day 1 4mg/kg IV 2 mg/kg IV weekly.
5815522|NCT00033514|Drug|erlotinib hydrochloride|100 mg daily on Course 1 Day 2. After three weeks patients who have not experienced specific adverse events, dose will be escalated to 150 mg daily. Patients who have experienced specific adverse events dose will remain 100 mg daily or dose reduced as necessary per protocol.
5815523|NCT00033488|Other|cytology specimen collection procedure|
5815524|NCT00033488|Procedure|annual screening|
5815525|NCT00033488|Procedure|comparison of screening methods|
5815526|NCT00033475|Biological|therapeutic allogeneic lymphocytes|
5815527|NCT00033449|Drug|gefitinib|Given orally
5815528|NCT00033449|Radiation|radiation therapy|Undergo radiation therapy
5815529|NCT00033449|Drug|cisplatin|Given IV
5815530|NCT00033449|Other|laboratory biomarker analysis|Correlative studies
5815531|NCT00033436|Dietary Supplement|niacinamide|
5815532|NCT00033436|Drug|carbogen|
5815533|NCT00033436|Radiation|radiation therapy|
5815534|NCT00033423|Biological|rituximab|
5815535|NCT00033423|Radiation|yttrium Y 90 ibritumomab tiuxetan|
5815536|NCT00033410|Drug|carboplatin|
5815537|NCT00033410|Drug|paclitaxel|
5815538|NCT00033410|Drug|tirapazamine|
5815539|NCT00033410|Radiation|radiation therapy|
5815540|NCT00033397|Procedure|biopsy|
5815541|NCT00033397|Procedure|magnetic resonance imaging|
5815542|NCT00033397|Procedure|radiomammography|
5815543|NCT00033397|Procedure|ultrasound imaging|
5815544|NCT00033397|Radiation|gadopentetate dimeglumine|
5815545|NCT00033397|Drug|chemotherapy|
5815546|NCT00033371|Drug|Celecoxib|Given 400 mg PO twice a day
5815547|NCT00033371|Other|Placebo|Given PO to match DFMO
5815548|NCT00033371|Drug|eflornithine|Given PO at 0.5 gm/m^2/day rounded down to the nearest 250 mg dose (BSA of < 1.4 = 500 mg/day; BSA of 1.5 - 2.0 = 750 mg/day; BSA of 2.1 - 2.5 = 1000 mg/day; BSA of > 2.6 = 1,250 mg/day).
5815549|NCT00033371|Other|Laboratory biomarker analysis|Correlative studies
5815550|NCT00033371|Other|Questionnaire administration|Ancillary studies
5815551|NCT00033358|Drug|medroxyprogesterone|Given intramuscularly
5815552|NCT00033358|Drug|ethinyl estradiol|Given orally
5815553|NCT00033358|Drug|norgestrel|Given orally
5815554|NCT00033358|Other|laboratory biomarker analysis|Correlative studies
5815555|NCT00033345|Drug|Indole-3-carbinol|400 mg pill taken daily
5815556|NCT00033345|Drug|Indole-3-carbinol|800 mg pill taken daily
5815557|NCT00033345|Other|Placebo|Placebo pill taken daily during run-in period
5815558|NCT00033332|Drug|dexamethasone|
5815559|NCT00033332|Drug|pamidronate disodium|
5815560|NCT00033332|Drug|thalidomide|
5815561|NCT00033332|Drug|zoledronic acid|
5815562|NCT00033293|Biological|therapeutic immune globulin|Given IV
5815563|NCT00033293|Other|clinical observation|Undergo observation
5815564|NCT00033293|Drug|cyclophosphamide|Given IV
5815565|NCT00033293|Drug|prednisone|Given orally
5815566|NCT00033293|Procedure|magnetic resonance imaging|Correlative studies
5815567|NCT00033293|Other|laboratory biomarker analysis|Correlative studies
5815568|NCT00033293|Drug|Corticotropin-Releasing Hormone|administered subcutaneously
5815569|NCT00033280|Drug|temozolomide|
5815570|NCT00033280|Procedure|neoadjuvant therapy|
5815571|NCT00033280|Radiation|radiation therapy|
5815572|NCT00033267|Drug|temsirolimus|Given IV
5815573|NCT00033254|Radiation|radiation therapy|Undergo conventional radiation therapy
5815574|NCT00033254|Drug|thalidomide|Given orally
5815575|NCT00033254|Procedure|quality-of-life assessment|Ancillary studies
5815576|NCT00033241|Drug|erlotinib hydrochloride|
5815577|NCT00033241|Drug|gemcitabine hydrochloride|
5815578|NCT00033228|Biological|MKC1106-MT|Cancer Vaccine, Immunotherapy, 500 ug
5815579|NCT00033228|Biological|MKC1106-MT|Cancer Vaccine, Immunotherapy, 1000 ug
5815580|NCT00033228|Biological|MKC1106-MT|Cancer Vaccine, Immunotherapy, 1500 ug
5815581|NCT00032188|Biological|aldesleukin|Given subcutaneously
5815582|NCT00032188|Drug|bryostatin 1|Given IV
5815583|NCT00032188|Other|laboratory biomarker analysis|Correlative studies
5815584|NCT00032175|Drug|capecitabine|
5815585|NCT00032175|Drug|gemcitabine hydrochloride|
5815586|NCT00032162|Drug|carboplatin|AUC 6 q4w
5815587|NCT00032162|Drug|pegylated liposomal doxorubicin hydrochloride|20/30/40 mg/qm q4w Dose finding study
5815588|NCT00032149|Biological|bleomycin sulfate|
5815589|NCT00032149|Biological|filgrastim|
5815590|NCT00032149|Drug|cyclophosphamide|
5815591|NCT00032149|Drug|etoposide|
5815592|NCT00032149|Drug|mitoxantrone hydrochloride|
5815593|NCT00032149|Drug|prednisolone|
5815594|NCT00032149|Drug|vincristine sulfate|
5815595|NCT00032136|Drug|exemestane|
5815596|NCT00032136|Drug|tamoxifen citrate|
5815597|NCT00032136|Procedure|adjuvant therapy|
5815598|NCT00032123|Drug|erlotinib hydrochloride|
5815599|NCT00032110|Drug|erlotinib hydrochloride|Given orally
5815600|NCT00032110|Other|pharmacological study|Correlative studies
5815601|NCT00032110|Other|laboratory biomarker analysis|Correlative studies
5815602|NCT00032097|Drug|motexafin gadolinium|
5815603|NCT00032097|Radiation|radiation therapy|
5815604|NCT00032084|Behavioral|smoking cessation intervention|Physician will deliver the smoking cessation advice, reinforce the established quit date (no sooner than seven days after starting bupropion/placebo), and will distribute patient educational materials and all pharmacotherapy
5815605|NCT00032084|Drug|bupropion hydrochloride|150 mg/day on Days 1-3, 300 mg/day on Day 4-77
5815606|NCT00032084|Drug|nicotine|21 mg patch/day for Weeks 2-7; 14 mg patch/day for Weeks 8-9; 7 mg patch/day for Weeks 10-11.
5815607|NCT00032084|Procedure|psychosocial assessment and care|The nurse/CRA will debrief the patients after the brief physician intervention and will follow-up with a series of 5 phone calls to provide booster advice. All advice will be based on the stage of change model (i.e., tailored to the patient's readiness to quit and/or stay off cigarettes).
5815608|NCT00032058|Procedure|magnetic resonance imaging|
5815609|NCT00032058|Procedure|magnetic resonance spectroscopic imaging|
5815610|NCT00032045|Biological|gp100 antigen|
5815611|NCT00032045|Biological|incomplete Freund's adjuvant|
5815612|NCT00032045|Biological|ipilimumab|
5815613|NCT00032032|Drug|carboplatin|
5815614|NCT00032032|Drug|paclitaxel|
5815615|NCT00032032|Radiation|radiation therapy|
5815616|NCT00032019|Biological|filgrastim|Cycle 1: 300 ug (BW < = 70 kg) or 480ug (BW >70 kg) sub Q injection Day 6 until ANC > 5000/uL after nadir counts Subsequent cycle dosages based on previous cycle toxicity or Day 1 Tx toxicity
5815617|NCT00032019|Biological|rituximab|375 mg/sq m IV infusion Day 1 Cycle 1 Subsequent cycle dosage based on previous cycle or day 1 of tx toxicities
5815618|NCT00032019|Drug|cyclophosphamide|750 mg/sq m IV infusion on Day 5 Cycle 1 Subsequent cycle dosage based on previous cycle or day 1 treatment toxicities
5815619|NCT00032019|Drug|doxorubicin hydrochloride|10 mg/sq m/day continuous IV infusion on Days 1-4 Cycle 1 Subsequent cycle dosages based on previous cycle and Day 1 treatment toxicities
5815620|NCT00032019|Drug|etoposide|50 mg/sq m/day continuous IV infusion Days 1-4 Cycle 1 Subsequent cycle dosages based on previous cycle and day 1 of treatment toxicities
5815621|NCT00032019|Drug|prednisone|60 mg/sq m PO bid days 1-5 of ea cycle
5815622|NCT00032019|Drug|vincristine sulfate|0.4 mg/sq m/day continuous IV infusion uncapped on Days 1-4 Cycle 1 Subsequent cycle dosages based on previous cycle and day 1 of treatment toxicities
5815623|NCT00032006|Radiation|brachytherapy|
5815624|NCT00032006|Radiation|radiation therapy|
5815625|NCT00031993|Drug|erlotinib hydrochloride|Given PO
5815626|NCT00031993|Other|laboratory biomarker analysis|Correlative studies
5815627|NCT00031980|Drug|cyclosporine|
5815628|NCT00031967|Drug|therapeutic melatonin|
5815629|NCT00031967|Radiation|radiation therapy|
5815630|NCT00031941|Drug|lenalidomide|
5815631|NCT00031928|Drug|mafosfamide|
5815632|NCT00031915|Drug|imatinib mesylate|
5815633|NCT00031902|Biological|bleomycin sulfate|
5815634|NCT00031902|Biological|rituximab|
5815635|NCT00031902|Drug|prednisolone|
5815636|NCT00031902|Drug|vincristine sulfate|
5815637|NCT00031876|Drug|capecitabine|
5815638|NCT00031876|Drug|paclitaxel|
5815639|NCT00031863|Drug|rofecoxib|
5815640|NCT00031863|Procedure|adjuvant therapy|
5815641|NCT00031850|Drug|goserelin acetate|
5815642|NCT00031850|Drug|raloxifene|
5815643|NCT00031837|Drug|dalteparin|
5815644|NCT00031837|Drug|gemcitabine hydrochloride|
5815645|NCT00031837|Procedure|quality-of-life assessment|
5815646|NCT00031824|Drug|cyclosporine|
5815647|NCT00031824|Drug|hydroxychloroquine|
5815648|NCT00031824|Drug|prednisone|
5815649|NCT00031824|Drug|tacrolimus|
5815650|NCT00031798|Drug|methylphenidate hydrochloride|
5815651|NCT00031798|Procedure|quality-of-life assessment|
5815652|NCT00031798|Radiation|radiation therapy|
5815653|NCT00031772|Procedure|psychosocial assessment and care|Questionnaire and telephone intervention
5815654|NCT00031759|Drug|imiquimod|
5815655|NCT00031759|Procedure|Ablative or excisional therapy|
5815656|NCT00031746|Dietary Supplement|soy protein isolate|25 mg daily
5815657|NCT00031746|Dietary Supplement|casein proteins|25 mg daily
5815658|NCT00031733|Biological|MART-1 antigen|
5815659|NCT00031733|Biological|gp100 antigen|
5815660|NCT00031733|Biological|incomplete Freund's adjuvant|
5815661|NCT00031733|Biological|recombinant interleukin-12|
5815662|NCT00031733|Biological|sargramostim|
5815663|NCT00031733|Biological|tyrosinase peptide|
5815664|NCT00031733|Drug|alum adjuvant|
5815665|NCT00031733|Procedure|adjuvant therapy|
5815666|NCT00031720|Dietary Supplement|soy protein|Given orally
5815667|NCT00031720|Dietary Supplement|isoflavones|Given orally
5815668|NCT00031720|Drug|Tamoxifen|
5815670|NCT00031694|Drug|paclitaxel|Given IV
5815671|NCT00031694|Drug|bryostatin 1|Given IV
5815672|NCT00031681|Drug|7-hydroxystaurosporine|Given IV
5815673|NCT00031681|Drug|irinotecan hydrochloride|Given IV
5815674|NCT00031681|Other|diagnostic laboratory biomarker analysis|Correlative studies
5815675|NCT00031655|Procedure|nonmyeloablative allogeneic hematopoietic stem cell transplantation|Undergo nonmyeloablative allogeneic PBSCT
5815676|NCT00031655|Biological|donor lymphocytes|Given IV
5815677|NCT00031655|Drug|cyclosporine|Given PO
5815678|NCT00031655|Radiation|total-body irradiation|Undergo TBI
5815679|NCT00031655|Drug|fludarabine phosphate|Given IV
5815680|NCT00031655|Drug|mycophenolate mofetil|Given PO
5815681|NCT00031655|Other|laboratory biomarker analysis|Correlative studies
5815682|NCT00031655|Procedure|peripheral blood stem cell transplantation|Undergo nonmyeloablative allogeneic PBSCT
5815683|NCT00031642|Biological|rituximab|
5815684|NCT00031642|Radiation|yttrium Y 90 ibritumomab tiuxetan|
5815685|NCT00031629|Drug|Docetaxel|Given IV
5815686|NCT00031629|Biological|Filgrastim|Given SC
5815687|NCT00031629|Drug|Gemcitabine Hydrochloride|Given IV
5815688|NCT00031629|Biological|Pegfilgrastim|Given IV
5815689|NCT00031616|Drug|brivudine phosphoramidate|
5815690|NCT00031590|Drug|Cisplatin|Given at a dose of 70mg/m2 by intravenous (IV) infusion over 8 hours on day 0 of each cycle (Regimen A only).
5815691|NCT00031590|Drug|Cyclophosphamide|Given at a dose of 1g/m2/day by IV infusion on days 0 and 1 of a 6-week cycle. Administration of cyclophosphamide will always be preceded by prehydration and Mesna (Regimen B only).
5815692|NCT00031590|Drug|Etoposide|Given at a dose of 150mg/m2/day by IV infusion on days 0 and 1 of a 6-week cycle. Given orally at a dose of 50mg/m2 as a single daily dose for 21 days beginning on day 14 of a cycle (Regimen B only).
5815693|NCT00031590|Drug|Lomustine|Given at a dose of 75mg/m2 taken orally on days 0 of each 6-week cycle with vincristine and cisplatin (Regimen A only).
5815694|NCT00031590|Drug|Vincristine|Given at a dose of 1.5mg/m2 given by IV infusion once a week for the first six weeks of treatment during radiation therapy. During maintenance therapy, it will be given as an IV push on days 0, 7 and 14 of each 6-week cycle (Regimen A only).
5815695|NCT00031590|Radiation|Craniospinal Radiation|Craniospinal radiation will begin within 28 days of surgery. Craniospinal Radiation therapy will last for 6 weeks, five days per week. Once a week during radiation, subjects will also be treated with chemotherapy (vincristine).
5815696|NCT00031577|Drug|paclitaxel|
5815697|NCT00031577|Radiation|radiation therapy|
5815698|NCT00031564|Biological|Interleukin-2|
5815699|NCT00031564|Biological|B7-1|
5815700|NCT00030914|Drug|medroxyprogesterone|
5815701|NCT00030914|Drug|venlafaxine|
5815702|NCT00030901|Drug|L-selenomethionine|Randomization between active L-selenomethionine and placebo
5815703|NCT00030901|Drug|L-selenomethionine placebo|Randomization between active L-selenomethionine and placebo
5815704|NCT00030888|Drug|7-hydroxystaurosporine|
5815705|NCT00030875|Drug|bortezomib|
5815706|NCT00030862|Drug|cisplatin|
5815707|NCT00030862|Drug|irinotecan hydrochloride|
5815708|NCT00030849|Biological|recombinant interferon alfa|
5815709|NCT00030849|Drug|bexarotene|
5815710|NCT00030823|Biological|Globo-H-GM2-Lewis-y-MUC1-32(aa)-sTn(c)-TF(c)-Tn(c)-KLH conjugate vaccine|
5815711|NCT00030823|Biological|QS21|
5815712|NCT00030810|Radiation|Hyperfractionated|Hyperfractionated radiotherapy
5815713|NCT00030810|Drug|Taxotere/Cisplatin|Taxotere/Cisplatin
5815714|NCT00030810|Procedure|conventional surgery|conventional surgery
5815715|NCT00030784|Drug|ifosfamide|
5815716|NCT00030784|Drug|pegylated liposomal doxorubicin hydrochloride|
5815717|NCT00030771|Drug|Chemotherapy|Docetaxel (Taxotere®) 85 mg/m2 1 hour iv infusion d1 Cisplatin 100 mg/m2 1 hour iv infusion d1 Schedule: 3 cycles repeated every 21 days
5815718|NCT00030771|Radiation|Radiotherapy|Radiotherapy (3 weeks after last chemotherapy administration) 44 Gy in 22 fractions concomitant boost technique in 3 weeks
5815719|NCT00030771|Procedure|Surgery|3-4 weeks after termination of radiotherapy
5815720|NCT00030758|Biological|filgrastim|
5815721|NCT00030758|Biological|pegfilgrastim|
5815722|NCT00030745|Drug|cisplatin|
5815723|NCT00030745|Drug|gemcitabine hydrochloride|
5815724|NCT00030745|Procedure|conventional surgery|
5815725|NCT00030732|Drug|Gemcitabine + Capecitabine|Gemcitabine + Capecitabine
5815726|NCT00030732|Drug|Gemcitabine alone|Gemcitabine alone
5815727|NCT00030719|Biological|filgrastim|
5815728|NCT00030719|Biological|monoclonal antibody Ch14.18|
5815729|NCT00030719|Drug|busulfan|
5815730|NCT00030719|Drug|carboplatin|
5815731|NCT00030719|Drug|cyclophosphamide|
5815732|NCT00030719|Drug|etoposide|
5815733|NCT00030719|Drug|isotretinoin|
5815734|NCT00030719|Drug|melphalan|
5815735|NCT00030719|Drug|vincristine sulfate|
5815736|NCT00030719|Procedure|bone marrow ablation with stem cell support|
5815737|NCT00030719|Procedure|conventional surgery|
5815738|NCT00030719|Procedure|peripheral blood stem cell transplantation|
5815739|NCT00030719|Radiation|radiation therapy|
5815740|NCT00030706|Drug|ixabepilone|
5815741|NCT00030693|Biological|recombinant fowlpox-B7.1 vaccine|Given intratumorally
5815742|NCT00030693|Biological|recombinant fowlpox-TRICOM vaccine|Given intratumorally
5815743|NCT00030693|Other|laboratory biomarker analysis|Correlative studies
5815744|NCT00030693|Procedure|quality-of-life assessment|Ancillary studies
5815745|NCT00030680|Radiation|radiation therapy|
5815746|NCT00030654|Drug|bicalutamide|
5815747|NCT00030654|Drug|docetaxel|
5815748|NCT00030654|Drug|doxorubicin hydrochloride|
5815749|NCT00030654|Drug|estramustine phosphate sodium|
5815750|NCT00030654|Drug|flutamide|
5815751|NCT00030654|Drug|ketoconazole|
5815752|NCT00030654|Drug|paclitaxel|
5815753|NCT00030654|Drug|releasing hormone agonist therapy|
5815754|NCT00030654|Drug|vinblastine sulfate|
5815755|NCT00030641|Biological|oblimersen sodium|
5815756|NCT00030641|Drug|docetaxel|
5815757|NCT00030628|Radiation|radiation therapy|
5815758|NCT00030628|Procedure|surgery|
5815759|NCT00030628|Radiation|WBRT|
5815760|NCT00030615|Drug|decitabine|Given IV
5815761|NCT00030615|Other|pharmacological study|Correlative studies
5815762|NCT00030615|Other|laboratory biomarker analysis|Correlative studies
5815763|NCT00030589|Drug|bexarotene|
5815764|NCT00030589|Drug|methoxsalen|
5815765|NCT00030589|Procedure|UV light therapy|
5815766|NCT00030576|Drug|cisplatin|
5815767|NCT00030576|Drug|erlotinib hydrochloride|
5815768|NCT00030563|Drug|irinotecan hydrochloride|
5815769|NCT00030563|Procedure|adjuvant therapy|
5815770|NCT00030563|Procedure|conventional surgery|
5815771|NCT00030563|Procedure|radiofrequency ablation|
5815772|NCT00030550|Drug|thalidomide|
5815773|NCT00030537|Drug|erlotinib hydrochloride|
5815774|NCT00030511|Drug|fluorouracil|
5815775|NCT00030511|Procedure|conventional surgery|
5815776|NCT00030511|Radiation|radiation therapy|
5815777|NCT00030498|Drug|erlotinib hydrochloride|Given orally
5815778|NCT00030498|Other|laboratory biomarker analysis|Correlative studies
5815779|NCT00030485|Drug|erlotinib hydrochloride|
5815780|NCT00030472|Drug|pegylated liposomal doxorubicin hydrochloride|
5815781|NCT00030459|Drug|cisplatin|
5815782|NCT00030459|Drug|mitomycin C|
5815783|NCT00030459|Drug|vinblastine sulfate|
5815784|NCT00030459|Drug|vinorelbine tartrate|
5815785|NCT00030433|Drug|gemcitabine hydrochloride|
5815786|NCT00030433|Drug|irinotecan hydrochloride|
5815787|NCT00030407|Drug|Celecoxib|On day -7 of the first cycle, patients will start, Celecoxib 400 mg po bid daily, each dose to give with meals
5815788|NCT00030407|Drug|Docetaxel|On day 1, 8, and 15 of each cycle patients will receive: Docetaxel 36mg/m2 over 60 minutes, duration of each cycle will be 28 days.
5815789|NCT00030394|Drug|imatinib mesylate|Given orally
5815790|NCT00030394|Other|laboratory biomarker analysis|Correlative studies
5815791|NCT00030394|Other|pharmacological study|Correlative studies
5815792|NCT00030355|Drug|homoharringtonine|
5815793|NCT00030355|Procedure|chemotherapy|
5815794|NCT00030342|Biological|recombinant interferon alfa|
5815795|NCT00030342|Biological|sargramostim|
5815796|NCT00030342|Biological|therapeutic autologous lymphocytes|
5815797|NCT00030342|Drug|fluorouracil|
5815798|NCT00030303|Biological|recombinant 70-kD heat-shock protein|
5815799|NCT00030290|Procedure|high-intensity focused ultrasound ablation|
5815800|NCT00030277|Procedure|high-intensity focused ultrasound ablation|
5815801|NCT00030264|Drug|Methotrexate|Methotrexate will be given at a dose of 30mg/m2/week intramuscular (IM) or intravenous (IV) for the first 26 weeks, then every 2 weeks for the next 26 weeks or until disease progression (whichever occurs first)
5815802|NCT00030264|Drug|Vinblastine|Vinblastine will be given at a dose of 6mg/m2/week intravenous (IV) for for the first 26 weeks, then every 2 weeks for the next 26 weeks or until disease progression (whichever occurs first). Maximum actual dose may not exceed 10mg.
5815803|NCT00030108|Drug|ixabepilone|
5815804|NCT00030095|Drug|2-methoxyestradiol|
5815805|NCT00030082|Drug|isolated perfusion|
5815806|NCT00030082|Drug|melphalan|
5815807|NCT00029029|Procedure|pain therapy|
5815808|NCT00029029|Procedure|radiofrequency ablation|
5815809|NCT00029003|Drug|gefitinib|Given orally
5815810|NCT00029003|Other|laboratory biomarker analysis|Correlative studies
5815811|NCT00028990|Drug|bevacizumab|10 mg/kg following paclitaxel treatment on weeks 1 and 3 of every 4-week cycle
5815812|NCT00028990|Drug|Paclitaxel|90 mg/m2 IV infusion over 1 hour every week for 3 weeks followed by 1 week rest
5815813|NCT00028977|Drug|herba scutellaria barbata|
5815814|NCT00028977|Other|herba scutellaria Barbatae (HSB)|
5815815|NCT00028964|Dietary Supplement|Chinese herbs|
5815816|NCT00028964|Drug|cyclophosphamide|
5815817|NCT00028964|Drug|doxorubicin hydrochloride|
5815818|NCT00028964|Procedure|adjuvant therapy|
5815819|NCT00028951|Drug|fibrin sealant|
5815820|NCT00028951|Procedure|surgical wound closure|
5815821|NCT00028912|Drug|bortezomib|
5815822|NCT00028912|Drug|carboplatin|
5815823|NCT00028899|Drug|asparaginase|
5815824|NCT00028899|Drug|cytarabine|
5815825|NCT00028899|Drug|gemtuzumab ozogamicin|
5815826|NCT00028899|Drug|mitoxantrone hydrochloride|
5815827|NCT00028886|Biological|filgrastim|
5815828|NCT00028886|Biological|recombinant interferon alfa|
5815829|NCT00028886|Drug|cyclophosphamide|
5815830|NCT00028886|Drug|dexamethasone|
5815831|NCT00028886|Drug|doxorubicin hydrochloride|
5815832|NCT00028886|Drug|melphalan|
5815833|NCT00028886|Drug|thalidomide|
5815834|NCT00028886|Drug|vincristine sulfate|
5815835|NCT00028886|Procedure|bone marrow ablation with stem cell support|
5815836|NCT00028886|Procedure|peripheral blood stem cell transplantation|
5815837|NCT00028873|Drug|docetaxel|
5815838|NCT00028873|Drug|laniquidar|
5815839|NCT00028873|Drug|paclitaxel|
5815840|NCT00028860|Biological|filgrastim|
5815841|NCT00028860|Drug|carboplatin|
5815842|NCT00028860|Drug|gemcitabine hydrochloride|
5815843|NCT00028860|Drug|ifosfamide|
5815844|NCT00028860|Drug|paclitaxel|
5815845|NCT00028860|Procedure|adjuvant therapy|
5815846|NCT00028847|Drug|cytarabine|
5815847|NCT00028847|Drug|imatinib mesylate|
5815848|NCT00028834|Drug|gemcitabine hydrochloride|Given IV
5815849|NCT00028834|Biological|bevacizumab|Given IV
5822959|NCT00002070|Drug|Sargramostim|
5815850|NCT00028834|Other|laboratory biomarker analysis|Correlative studies
5815851|NCT00028821|Drug|2-methoxyestradiol|Given orally
5815852|NCT00028821|Other|pharmacological study|Correlative studies
5815853|NCT00028821|Other|laboratory biomarker analysis|Correlative studies
5815854|NCT00028795|Drug|temozolomide|
5815855|NCT00028795|Procedure|adjuvant therapy|
5815856|NCT00028795|Radiation|radiation therapy|
5815857|NCT00028782|Drug|etanidazole|Given IV
5815858|NCT00028782|Procedure|therapeutic conventional surgery|Undergo surgery
5815859|NCT00028782|Other|laboratory biomarker analysis|Correlative studies
5815860|NCT00028769|Drug|bicalutamide|
5815861|NCT00028769|Drug|estramustine|
5815862|NCT00028769|Drug|etoposide|
5815863|NCT00028769|Drug|flutamide|
5815864|NCT00028769|Drug|goserelin|
5815865|NCT00028769|Drug|leuprolide|
5815866|NCT00028769|Drug|nilutamide|
5815867|NCT00028769|Drug|paclitaxel|
5815868|NCT00028756|Drug|doxorubicin hydrochloride|Given IV
5815869|NCT00028756|Drug|gemcitabine hydrochloride|Given IV
5815870|NCT00028756|Drug|vinblastine sulfate|Given IV
5815871|NCT00028756|Drug|methotrexate|Given IV
5815872|NCT00028756|Drug|cisplatin|Given IV
5815873|NCT00028756|Biological|filgrastim|Given SC
5815874|NCT00028743|Drug|carboplatin|Arm 1 = 4 cycles vs Arm 2 = 8 cycles AUC5 (30 mins) day 1 of 21 day cycle
5815875|NCT00028743|Drug|cisplatin|4 cycles 50mg/m2 (60 mins) day 1 of 21 day cycle
5815876|NCT00028743|Drug|paclitaxel|Arm 1 = 4 cycles vs Arm 2 = 8 cycles 175mg/m2 (3 hours) day 1 of 21 day cycle
5815877|NCT00028743|Drug|topotecan hydrochloride|"4 cycles~.75mg/m2 (30 mins) days 1-5 of 21 day cycle"
5815878|NCT00028730|Biological|anti-thymocyte globulin|
5815879|NCT00028730|Biological|filgrastim|
5815880|NCT00028730|Drug|cyclophosphamide|
5815881|NCT00028730|Drug|fludarabine phosphate|
5815882|NCT00028730|Drug|thiotepa|
5815883|NCT00028730|Procedure|allogeneic bone marrow transplantation|
5815884|NCT00028730|Radiation|radiation therapy|
5815885|NCT00028717|Biological|filgrastim|
5815886|NCT00028717|Biological|rituximab|
5815887|NCT00028717|Drug|cyclophosphamide|
5815888|NCT00028717|Drug|doxorubicin hydrochloride|
5815889|NCT00028717|Drug|prednisone|
5815890|NCT00028717|Drug|vincristine sulfate|
5815891|NCT00028704|Procedure|conventional surgery|
5815892|NCT00028704|Radiation|radiation therapy|
5815893|NCT00028691|Drug|chlorambucil|
5815894|NCT00028691|Radiation|radiation therapy|
5815895|NCT00028665|Biological|filgrastim|Beginning 36-48 hours after the completion of cyclophosphamide, patients receive filgrastim (G-CSF) subcutaneously (SC) daily until blood counts recover. Patients receive G-CSF SC daily beginning 4 hours after completion of PBSC infusion and continuing until neutrophil engraftment.
5815896|NCT00028665|Biological|rituximab|rituximab IV over 2-5 hours on days 1, 8, and 15
5815897|NCT00028665|Drug|carmustine|After completion of PBSC collection, patients receive high-dose chemotherapy comprising carmustine IV on days -7 to -3
5815898|NCT00028665|Drug|cisplatin|After completion of PBSC collection, cisplatin IV for 3 days during days -7 to -3.
5815899|NCT00028665|Drug|cyclophosphamide|cyclophosphamide IV over 3-6 hours on day 16.
5815900|NCT00028665|Drug|etoposide|After completion of PBSC collection, etoposide IV for 3 days during days -7 to -3.
5815901|NCT00028665|Procedure|bone marrow ablation with stem cell support|Patients then undergo peripheral blood stem cell (PBSC) collection.
5815902|NCT00028665|Procedure|peripheral blood stem cell transplantation|Arm I: Patients receive unmanipulated PBSCs on day 0. Arm II: Patients receive CD34 cell-enriched PBSC on day 0.
5815903|NCT00028665|Radiation|radiation therapy|Patients may undergo involved-field radiotherapy to active or previously bulky (more than 5 cm) tumors daily for 7-10 days.
5815904|NCT00028652|Biological|interleukin-12 gene|
5815905|NCT00028639|Drug|bortezomib|
5815906|NCT00028626|Drug|embolization therapy|
5815907|NCT00028600|Biological|filgrastim|PBSC collection: 10 ug/kg/d subQ inj D 5 until completion of collection Auto transpl: 5 ug/kg/d subQ inj D 5 until ANC >= 1500/uL for 2d or 5000/uL for 1 d Allo transpl: 5ug/kg/d subQ inj D 7 until ANC > 1000/uL for 3 days Donor pheresis: 10ug/kg/d subQ inj d -5 thru -2
5815908|NCT00028600|Biological|CD34+ cells|2-8,000,000/kg IV infusion allogeneic transplant 2,000,000/kg IV infusion autologous transplant
5815909|NCT00028600|Drug|cyclophosphamide|4g/sq m IV infusion over 1-2 hrs D 1 for auto, and 1g/sq m/d IV infusion over 1 hr on D -4 thru -3 for allo, transplant prep
5815910|NCT00028600|Drug|fludarabine phosphate|30mg/sq m/d IVPB over 30 min d -7 thru -3 allo transpl
5815911|NCT00028600|Drug|melphalan|200mg/sq m IV infusion over 15-30 min D 2 auto transpl
5815912|NCT00028600|Drug|methotrexate|5mg/sq m/d IV infusion D 1,3,& 6: allo transpl
5815913|NCT00028600|Drug|tacrolimus|0.03mg/kg PO bid starting dose, D -1 thru +90, then taper thru D +150
5815914|NCT00028587|Drug|bortezomib|Given IV
5815915|NCT00028587|Drug|paclitaxel|Given IV
5815916|NCT00028587|Drug|carboplatin|Given IV
5815917|NCT00028587|Other|laboratory biomarker analysis|Optional correlative studies
5815918|NCT00028574|Drug|gabapentin|
5815919|NCT00028574|Other|placebo|
5815920|NCT00028561|Drug|ixabepilone|Given IV
5815921|NCT00028561|Drug|carboplatin|Given IV
5815922|NCT00028561|Other|laboratory biomarker analysis|Correlative studies
5815923|NCT00028561|Other|pharmacological study|Correlative studies
5815924|NCT00028548|Drug|R(+)XK469|
5815925|NCT00028535|Biological|trastuzumab|Given IV
5815926|NCT00028535|Drug|paclitaxel|Given IV
5815927|NCT00028535|Biological|recombinant interleukin-12|Given SC
5815928|NCT00028522|Drug|R(+)XK469|Given IV
5815929|NCT00028509|Procedure|management of therapy complications|
5815930|NCT00028496|Biological|recombinant fowlpox-CEA(6D)/TRICOM vaccine|Given intradermally
5815931|NCT00028496|Biological|sargramostim|Given subcutaneously
5815932|NCT00028496|Biological|recombinant fowlpox GM-CSF vaccine adjuvant|Given intradermally
5815933|NCT00028028|Drug|temsirolimus|Given IV
5815934|NCT00028028|Other|pharmacological study|Correlative studies
5815935|NCT00028028|Other|laboratory biomarker analysis|Correlative studies
5815936|NCT00028015|Drug|SarCNU|
5815937|NCT00028002|Procedure|Conventional Surgery|Undergo surgical resection
5815938|NCT00028002|Drug|Imatinib Mesylate|Given orally
5815939|NCT00027989|Drug|gemcitabine hydrochloride|
5815940|NCT00027989|Drug|pegylated liposomal doxorubicin hydrochloride|
5815941|NCT00027976|Drug|celecoxib|
5815942|NCT00027976|Drug|Placebo|
5815943|NCT00027963|Drug|gabapentin|
5815944|NCT00027963|Other|placebo|
5815945|NCT00027937|Biological|aldesleukin|
5815946|NCT00027937|Biological|filgrastim|
5815947|NCT00027937|Biological|sargramostim|
5815948|NCT00027937|Drug|busulfan|
5815949|NCT00027937|Drug|cyclophosphamide|
5815950|NCT00027937|Drug|melphalan|
5815951|NCT00027937|Drug|paclitaxel|
5815952|NCT00027937|Drug|thiotepa|
5815953|NCT00027937|Procedure|bone marrow ablation with stem cell support|
5815954|NCT00027937|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5815955|NCT00027911|Biological|NY-ESO-1 peptide vaccine|
5815956|NCT00027911|Biological|sargramostim|
5815957|NCT00027898|Drug|bortezomib|Given IV
5815958|NCT00027898|Drug|carboplatin|Given IV
5815959|NCT00027898|Drug|etoposide|Given IV
5815960|NCT00027898|Other|laboratory biomarker analysis|Correlative studies
5815961|NCT00027898|Other|pharmacological study|Correlative studies
5815962|NCT00027885|Biological|bevacizumab|Patients receive bevacizumab IV over 60 minutes once every 2 weeks on weeks 1-8.
5815963|NCT00027885|Drug|cyclophosphamide|Approximately 4 weeks after the completion of radiotherapy, patients receive cyclophosphamide IV over 30-60 minutes on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.
5815964|NCT00027885|Drug|docetaxel|Patients receive docetaxel IV over 1 hour once weekly on weeks 1-6.
5815965|NCT00027885|Drug|doxorubicin hydrochloride|Approximately 4 weeks after the completion of radiotherapy, patients receive doxorubicin IV over 5 minutes. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity.
5815966|NCT00027885|Procedure|adjuvant therapy|"After the second course, patients with stable or responsive disease undergo modified radical mastectomy or breast-conserving surgery. Three to six weeks after surgery, patients undergo radiotherapy 5 days a week for 7 weeks.~Approximately 4 weeks after the completion of radiotherapy, patients receive doxorubicin IV over 5 minutes and cyclophosphamide IV over 30-60 minutes on day 1. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity."
5815967|NCT00027885|Procedure|conventional surgery|After the second course, patients with stable or responsive disease undergo modified radical mastectomy or breast-conserving surgery.
5815968|NCT00027885|Procedure|neoadjuvant therapy|"Arm I: Patients receive docetaxel IV over 1 hour once weekly on weeks 1-6 and bevacizumab IV over 60 minutes once every 2 weeks on weeks 1-8.~Arm II: Patients receive docetaxel as in arm I. Treatment in both arms repeats every 8 weeks for 2 courses in the absence of disease progression or unacceptable toxicity."
5815969|NCT00027885|Radiation|radiation therapy|Three to six weeks after surgery, patients undergo radiotherapy 5 days a week for 7 weeks.
5815970|NCT00027872|Drug|tipifarnib|Given orally
5815971|NCT00027872|Other|laboratory biomarker analysis|Correlative studies
5815972|NCT00027859|Drug|docetaxel|
5815973|NCT00027859|Drug|estramustine phosphate sodium|
5815974|NCT00027859|Drug|ketoconazole|
5815975|NCT00027859|Drug|therapeutic hydrocortisone|
5815976|NCT00027846|Biological|filgrastim|Given IV or SC (5mcg/kg/day) start on Day 3 and continue until ANC >1500/μl given subcutaneously or intravenously.
5815977|NCT00027846|Drug|carboplatin|Given IV (375 mg/m2/day) Day 1 given as an IV infusion over one hour. For patients with BSA <0.45m2 the dose is 12.5 mg/kg/day.
5815978|NCT00027846|Drug|cyclophosphamide|Given IV (1000mg/m2/day) Day 1 and 2 given as an IV infusion over one hour following carboplatin administration. For patients with BSA<0.45m2 the dose is 33mg/kg/day on Day 1 and 2.
5815979|NCT00027846|Drug|etoposide|Given orally (50 mg/m2/day) orally once daily on Days 1 through 21. For patients with BSA < 0.45 m2, the dosage is 1.7 mg/kg/day on Days 1 through 21.
5815980|NCT00027846|Drug|vincristine sulfate|Given IV or orally (1.5mg/m2/day) (maximum dose 2 mg) Day 1 and 8 given as IV bolus. For patients with BSA<0.45m2 the dose is 0.05mg/kg.
5815981|NCT00027846|Radiation|radiation therapy|Given once daily 5 days a week for 6-6½ weeks
5815982|NCT00027846|Drug|Mesna|Mesna (200mg/m2/dose) Day 1 and 2. For patients with BSA<0.45m2 the dose is (7mg/kg/dose). Combine mesna (200mg/m2) with cyclophosphamide and administer intravenously over one hour followed by mesna (200mg/m2) in 375 cc/m2 D5-1/2NS and run intravenously over 3 hours at 125cc/m2/hr. After 3 hour mesna, administer mesna (200 mg/m2/dose) IV over 15 minutes at hour 5.
5815983|NCT00027846|Procedure|therapeutic conventional surgery|
5815984|NCT00027833|Biological|ALVAC-CEA-B7.1 vaccine|
5815985|NCT00027833|Biological|tetanus toxoid|
5815986|NCT00027833|Drug|FOLFIRI regimen|
5815987|NCT00027833|Drug|fluorouracil|
5815988|NCT00027833|Drug|irinotecan hydrochloride|
5815989|NCT00027833|Drug|leucovorin calcium|
5815990|NCT00027820|Drug|Fludarabine Phosphate|Given IV
5815991|NCT00027820|Radiation|Total-Body Irradiation|Undergo TBI
5815992|NCT00027820|Procedure|Peripheral Blood Stem Cell Transplantation|Undergo nonmyeloablative PBSCT
5815993|NCT00027820|Procedure|Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|Undergo nonmyeloablative PBSCT
5815994|NCT00027820|Drug|Cyclosporine|Given PO
5815995|NCT00027820|Drug|Mycophenolate Mofetil|Given PO
5815996|NCT00027807|Biological|Aldesleukin|Subcutaneous injections of IL-2 (3.0 × 105 IU/m2/day) starting 3 days before the 1st armed ATC infusion and ending 7 days after the last armed ATC infusion.
5822960|NCT00002070|Drug|Ganciclovir|
5815997|NCT00027807|Biological|Sargramostim|GM-CSF Injections will be given SQ GM-CSF (250 μg/m2/twice weekly), to start 3 days before the first ATC infusion and ending 1 week after the last ATC infusion.
5815998|NCT00027807|Biological|therapeutic autologous lymphocytes|The time for armed-ATC infusions will vary from patient to patient, but the dose of armed-ATC (up to 40 billion) will be given over 30 min.
5815999|NCT00027794|Procedure|conventional surgery|
5816000|NCT00027781|Drug|sabarubicin|
5816001|NCT00027768|Procedure|adjuvant therapy|
5816002|NCT00027768|Radiation|iodine I 131 ethiodized oil|
5816003|NCT00027742|Biological|pegylated interferon alfa|
5816004|NCT00027742|Drug|temozolomide|
5816005|NCT00027729|Biological|etaracizumab|
5816006|NCT00027716|Drug|bortezomib|
5816007|NCT00027703|Drug|gemcitabine hydrochloride|Given IV
5816008|NCT00027703|Drug|cisplatin|Given IV
5816009|NCT00027703|Biological|bevacizumab|Given IV
5816010|NCT00027703|Other|placebo|Given IV
5816011|NCT00027703|Other|laboratory biomarker analysis|Correlative studies
5816012|NCT00027690|Drug|Gefitinib|Given orally
5816013|NCT00027690|Other|Laboratory Biomarker Analysis|Correlative studies
5816014|NCT00027677|Drug|halofuginone hydrobromide|
5816015|NCT00027664|Biological|recombinant interferon alfa|
5816016|NCT00027664|Drug|thalidomide|
5816017|NCT00027638|Drug|thalidomide|
5816018|NCT00027625|Drug|gefitinib|
5816019|NCT00027625|Drug|temozolomide|
5816020|NCT00027586|Drug|Imatinib mesylate (STI571)|400 mg twice a day orally
5816021|NCT00027573|Biological|filgrastim|
5816022|NCT00027573|Biological|therapeutic allogeneic lymphocytes|
5816023|NCT00027573|Drug|cyclophosphamide|
5816024|NCT00027573|Drug|fludarabine phosphate|
5816025|NCT00027573|Drug|methotrexate|
5816026|NCT00027573|Drug|tacrolimus|
5816027|NCT00027573|Procedure|peripheral blood stem cell transplantation|
5816028|NCT00027560|Biological|alemtuzumab|"Consenting individuals will receive pretransplant immunosuppressive cytoreduction, which will consist of 4 days of Campath-1H, 5 days of fludarabine, and two days of melphalan. All therapy should be completed approximately 24-36 hours before administration of the primary allograft.~Campath-1H (20mg/dose/day) will be administered for each of four days from day -8 to day -5, inclusive. Each dose will be infused intravenously over 8 hours."
5816029|NCT00027560|Drug|cyclosporine|Patients will be treated with Cyclosporine as prophylaxis against GvHD. Cyclosporine will be initiated at least 1 day prior to transplant at a dose of 1.5 mg / kg IV q12h (3 mg / kg / day = total daily dose). Dose will thereafter be adjusted to maintain a trough serum level of 200-300 ng /ml. Cyclosporine will be administered intravenously until the patient tolerates full alimentation, at which time conversion to oral dosing to sustain therapeutic levels will be initiated according to standard BMT service guidelines.
5816030|NCT00027560|Drug|fludarabine phosphate|Fludarabine, 25mg/m2/d will be administered for each of five days from day -8 to day -4, inclusive. Each dose will be infused intravenously over 30 minutes.
5816031|NCT00027560|Drug|melphalan|Melphalan will be administered intravenously over 30 minutes on each of two days from day -3 to day -2, inclusive. The dose for recipients of HLA-matched related grafts will be 50 mg/m2/day x 2. The dose for recipients of HLA-matched unrelated and HLA-single allele disparate related or unrelated marrow or PBSC transplants will be 70 mg/m2/day x 2.
5816032|NCT00027560|Procedure|allogeneic bone marrow transplantation|
5816033|NCT00027560|Procedure|peripheral blood stem cell transplantation|
5816034|NCT00027547|Biological|therapeutic allogeneic lymphocytes|
5816035|NCT00027547|Drug|cyclosporine|
5816036|NCT00027547|Drug|cytarabine|
5816037|NCT00027547|Drug|fludarabine phosphate|
5816038|NCT00027547|Drug|methotrexate|
5816039|NCT00027547|Drug|mycophenolate mofetil|
5816040|NCT00027547|Procedure|allogeneic bone marrow transplantation|
5816041|NCT00027547|Procedure|peripheral blood stem cell transplantation|
5816042|NCT00027547|Radiation|radiation therapy|
5816043|NCT00027534|Biological|TRICOM-CEA(6D)|dendritic cells loaded with TRICOM-CEA(6D)
5816044|NCT00027495|Dietary Supplement|curcumin|
5816045|NCT00026533|Drug|thalidomide|
5816046|NCT00026494|Drug|temozolomide|
5816047|NCT00026494|Drug|vinorelbine tartrate|
5816048|NCT00026468|Drug|exisulind|
5816049|NCT00026442|Drug|capecitabine|
5816050|NCT00026416|Biological|recombinant interferon alfa|
5816051|NCT00026416|Drug|thalidomide|
5816052|NCT00026416|Procedure|adjuvant therapy|
5816053|NCT00026403|Drug|cisplatin|
5816054|NCT00026403|Drug|gemcitabine hydrochloride|
5816055|NCT00026403|Radiation|radiation therapy|
5816056|NCT00026338|Drug|erlotinib hydrochloride|150 mg po daily
5816057|NCT00026338|Drug|gemcitabine hydrochloride|1000 mg/m2 IV weekly (Cycle 1 -Day 1, 8, 15, 22, 29, 36, 43 of an 8 week cycle, Cycle 2 and subsequent cycles -Day 1,8 and 15 of a 4 week cycle)
5816058|NCT00026312|Biological|Aldesleukin|Given IV
5816059|NCT00026312|Biological|Dinutuximab|Given IV
5816060|NCT00026312|Drug|Isotretinoin|Given PO
5816061|NCT00026312|Other|Laboratory Biomarker Analysis|Correlative studies
5816062|NCT00026312|Other|Pharmacological Study|Correlative studies
5816063|NCT00026312|Other|Quality-of-Life Assessment|Ancillary studies
5816064|NCT00026312|Biological|Sargramostim|Given IV or SC
5816065|NCT00026299|Drug|ZD1839|
5816066|NCT00026299|Drug|oxaliplatin|
5816067|NCT00026247|Procedure|pain therapy|
5816068|NCT00026247|Procedure|radiofrequency ablation|
5816069|NCT00026234|Drug|floxuridine|Given intra-arterially
5816070|NCT00026234|Drug|dexamethasone|Given intra-arterially
5816071|NCT00026234|Drug|oxaliplatin|Given IV
5816072|NCT00026234|Drug|capecitabine|Given orally
5816073|NCT00026221|Biological|Recombinant Interferon Alfa|Given SC
5816074|NCT00026221|Biological|Bevacizumab|Given IV
5816075|NCT00026208|Drug|Vincristine|1.4 mg/m² intravenously (IV) on week 2, 4, 6, 8
5816076|NCT00026208|Drug|Cyclophosphamide|650 mg/m², on week 1 and 5
5816077|NCT00026208|Drug|Doxorubicin|25 mg/m², on week 1, 3, 5, 7
5816078|NCT00026208|Drug|Prednisone|40 mg/m², oral, every other day. Taper-reduction 10 mg/m² every other day during last 2 weeks of chemotherapy
5816079|NCT00026208|Drug|Bleomycin|5 u/m² intravenously (IV) on week 2, 4, 6, 8
5816080|NCT00026208|Drug|Etoposide|60 mg/m² x 2 intravenously (IV) on week 3, 7 (d 15, 16, 43, 44)
5816081|NCT00026208|Radiation|Low-dose radiotherapy (RT)|20 Grey (Gy) modified involved field radiotherapy administered as consolidative irradiation will beginning between 2 and 12 weeks after the completion of Stanford V-C chemotherapy regimen.
5816082|NCT00026195|Drug|irinotecan hydrochloride|
5816083|NCT00026182|Biological|rituximab|Given IV
5816084|NCT00026182|Biological|recombinant interleukin-12|Given SC
5816085|NCT00026182|Other|laboratory biomarker analysis|Correlative studies
5816086|NCT00026182|Other|questionnaire administration|Ancillary studies
5816087|NCT00026182|Procedure|quality-of-life assessment|Ancillary studies
5816088|NCT00026169|Drug|imatinib mesylate|Given orally
5816089|NCT00026169|Other|laboratory biomarker analysis|Correlative studies
5816090|NCT00026169|Other|pharmacological study|Correlative studies
5816091|NCT00026156|Drug|docetaxel|
5816092|NCT00026156|Drug|vinorelbine tartrate|
5816093|NCT00026143|Biological|recombinant interleukin-12|Given IV
5816094|NCT00026143|Biological|recombinant interferon alfa|Given SC
5816095|NCT00026143|Other|laboratory biomarker analysis|Correlative studies
5816096|NCT00026130|Drug|fluorouracil|200mg/sq m/d CIVI 5/7 days during radiation therapy (wks 1-6)
5816097|NCT00026130|Drug|gemcitabine hydrochloride|200mg/sq m IV infusion over 30 min wkly (on d 1, 2, OR 3) during radiation tx (wks 1-6) 1000mg/sq m IV infusion over 30 min wkly for 3 weeks during ea chemotherapy cycle
5816098|NCT00026130|Radiation|radiation therapy|4500cGy total in 25 fractions M-F followed by 540cGy in 3 fractions (Total dose 5040cGy)during radiation tx (wks 1-6)
5816099|NCT00026117|Drug|BenFin|
5816100|NCT00026117|Other|placebo|
5816101|NCT00026104|Drug|gemcitabine hydrochloride|Given IV
5816102|NCT00026104|Drug|paclitaxel|Given IV
5816103|NCT00026104|Drug|tipifarnib|Given orally
5816104|NCT00026104|Radiation|radiation therapy|Undergo radiation therapy
5816105|NCT00026091|Drug|fenretinide|Given orally
5816106|NCT00026091|Other|laboratory biomarker analysis|Correlative studies
5816107|NCT00026091|Other|pharmacological study|Correlative studies
5816108|NCT00026078|Drug|docetaxel|
5816109|NCT00026078|Drug|ifosfamide|
5816110|NCT00025675|Drug|gefitinib|
5816111|NCT00025662|Drug|RFT5-SMPT-dgA|A specific anti-interleukin-2 receptor immunotoxin
5816112|NCT00025662|Drug|Isolex system|CD34 selection/ T cell depletion used this system
5816113|NCT00025649|Biological|filgrastim|
5816114|NCT00025649|Drug|busulfan|
5816115|NCT00025649|Drug|carboplatin|
5816116|NCT00025649|Drug|cyclophosphamide|
5816117|NCT00025649|Drug|doxorubicin hydrochloride|
5816118|NCT00025649|Drug|etoposide|
5816119|NCT00025649|Drug|melphalan|
5816120|NCT00025649|Drug|vincristine sulfate|
5816121|NCT00025649|Procedure|autologous bone marrow transplantation|
5816122|NCT00025649|Procedure|conventional surgery|
5816123|NCT00025649|Procedure|peripheral blood stem cell transplantation|
5816124|NCT00025636|Biological|filgrastim|
5816125|NCT00025636|Drug|carmustine|
5816126|NCT00025636|Drug|cisplatin|
5816127|NCT00025636|Drug|cyclophosphamide|
5816128|NCT00025636|Drug|cytarabine|
5816129|NCT00025636|Drug|dexamethasone|
5816130|NCT00025636|Drug|etoposide|
5816131|NCT00025636|Drug|melphalan|
5816132|NCT00025636|Drug|methotrexate|
5816133|NCT00025636|Drug|vincristine sulfate|
5816134|NCT00025636|Procedure|bone marrow ablation with stem cell support|
5816135|NCT00025636|Procedure|peripheral blood stem cell transplantation|
5816136|NCT00025623|Drug|carboplatin|
5816137|NCT00025623|Drug|cyclophosphamide|
5816138|NCT00025623|Drug|doxorubicin hydrochloride|
5816139|NCT00025623|Drug|etoposide|
5816140|NCT00025623|Drug|vincristine sulfate|
5816141|NCT00025623|Procedure|conventional surgery|
5816142|NCT00025610|Drug|carboplatin|
5816143|NCT00025610|Drug|cyclophosphamide|
5816144|NCT00025610|Drug|doxorubicin hydrochloride|
5816145|NCT00025610|Drug|etoposide|
5816146|NCT00025610|Drug|vincristine sulfate|
5816147|NCT00025597|Drug|carboplatin|
5816148|NCT00025597|Drug|cyclophosphamide|
5816149|NCT00025597|Drug|doxorubicin hydrochloride|
5816150|NCT00025597|Drug|etoposide|
5816151|NCT00025597|Drug|vincristine sulfate|
5816152|NCT00025597|Procedure|conventional surgery|
5816153|NCT00025584|Drug|bortezomib|Given IV
5816154|NCT00025584|Other|laboratory biomarker analysis|Correlative studies
5816155|NCT00025558|Biological|filgrastim|
5816156|NCT00025558|Drug|carboplatin|
5816157|NCT00025558|Drug|temozolomide|
5816158|NCT00025558|Drug|thiotepa|
5816159|NCT00025558|Procedure|autologous bone marrow transplantation|
5816160|NCT00025558|Procedure|peripheral blood stem cell transplantation|
5816161|NCT00025519|Biological|therapeutic allogeneic lymphocytes|
5816162|NCT00025519|Drug|fludarabine phosphate|
5816163|NCT00025519|Drug|mycophenolate mofetil|
5816164|NCT00025519|Drug|tacrolimus|
5816165|NCT00025519|Drug|thalidomide|
5816166|NCT00025519|Procedure|peripheral blood stem cell transplantation|
5816167|NCT00025519|Radiation|radiation therapy|
5816168|NCT00025506|Other|Laboratory Biomarker Analysis|Correlative studies
5816169|NCT00025506|Drug|Thalidomide|Given orally
5816170|NCT00025493|Drug|docetaxel|
5816171|NCT00025480|Drug|carboplatin|
5816174|NCT00025480|Radiation|radiation therapy|
5816175|NCT00025454|Drug|tipifarnib|
5816176|NCT00025441|Biological|dactinomycin|
5816177|NCT00025441|Biological|filgrastim|
5816178|NCT00025441|Drug|carboplatin|
5816179|NCT00025441|Drug|cyclophosphamide|
5816180|NCT00025441|Drug|doxorubicin hydrochloride|
5816181|NCT00025441|Drug|epirubicin hydrochloride|
5816182|NCT00025441|Drug|etoposide|
5816183|NCT00025441|Drug|ifosfamide|
5816184|NCT00025441|Drug|vincristine sulfate|
5816185|NCT00025441|Procedure|peripheral blood stem cell transplantation|
5816186|NCT00025441|Radiation|radiation therapy|
5816187|NCT00025428|Drug|carboplatin|
5816188|NCT00025428|Drug|cyclophosphamide|
5816189|NCT00025428|Drug|doxorubicin hydrochloride|
5816190|NCT00025428|Drug|etoposide|
5816191|NCT00025428|Drug|vincristine sulfate|
5816192|NCT00025428|Procedure|adjuvant therapy|
5816193|NCT00025428|Procedure|conventional surgery|
5816194|NCT00025428|Procedure|neoadjuvant therapy|
5816195|NCT00025415|Drug|imatinib mesylate|Given orally
5816196|NCT00025415|Other|pharmacological study|Correlative studies
5816197|NCT00025402|Biological|filgrastim|
5816198|NCT00025402|Biological|recombinant interferon alfa|
5816199|NCT00025402|Drug|busulfan|
5816200|NCT00025402|Drug|cyclophosphamide|
5816201|NCT00025402|Drug|cytarabine|
5816202|NCT00025402|Drug|etoposide|
5816203|NCT00025402|Drug|hydroxyurea|
5816204|NCT00025402|Drug|idarubicin|
5816205|NCT00025402|Procedure|allogeneic bone marrow transplantation|
5816206|NCT00025402|Procedure|peripheral blood stem cell transplantation|
5816207|NCT00025402|Radiation|radiation therapy|
5816208|NCT00025389|Biological|bevacizumab|
5816209|NCT00025389|Drug|carboplatin|
5816210|NCT00025389|Drug|paclitaxel|
5816211|NCT00025389|Procedure|conventional surgery|
5816212|NCT00025389|Procedure|neoadjuvant therapy|
5816213|NCT00025363|Drug|vincristine sulfate|Given IV
5816214|NCT00025363|Drug|irinotecan hydrochloride|Given IV
5816215|NCT00025363|Drug|cyclophosphamide|Given IV
5816216|NCT00025363|Drug|doxorubicin hydrochloride|Given IV
5816217|NCT00025363|Drug|ifosfamide|Given IV
5816218|NCT00025363|Drug|etoposide|Given IV
5816219|NCT00025363|Drug|tirapazamine|Given IV
5816220|NCT00025363|Biological|filgrastim|Given SC
5816221|NCT00025363|Biological|sargramostim|Given SC
5816222|NCT00025363|Other|pharmacological study|Correlative studies
5816223|NCT00025363|Other|pharmacogenomic studies|Correlative studies
5816224|NCT00025363|Other|laboratory biomarker analysis|Correlative studies
5816225|NCT00025337|Biological|bevacizumab|Given IV
5816226|NCT00025337|Drug|oxaliplatin|Given IV
5816227|NCT00025337|Drug|leucovorin calcium|Given IV
5816228|NCT00025337|Drug|fluorouracil|Given IV
5816229|NCT00025324|Biological|filgrastim|
5816230|NCT00025324|Drug|carboplatin|
5816231|NCT00025324|Drug|cyclophosphamide|
5816232|NCT00025324|Drug|etoposide|
5816233|NCT00025324|Drug|thiotepa|
5816234|NCT00025324|Procedure|autologous bone marrow transplantation|
5816235|NCT00025324|Procedure|bone marrow ablation with stem cell support|
5816236|NCT00025324|Procedure|conventional surgery|
5816237|NCT00025324|Procedure|peripheral blood stem cell transplantation|
5816238|NCT00025324|Radiation|radiation therapy|
5816239|NCT00025311|Drug|topotecan hydrochloride|
5816240|NCT00025298|Drug|amifostine trihydrate|
5816241|NCT00025298|Drug|carboplatin|
5816242|NCT00025298|Drug|cisplatin|
5816243|NCT00025298|Drug|paclitaxel|
5816244|NCT00025298|Radiation|radiation therapy|
5816245|NCT00025285|Drug|carboplatin|
5816246|NCT00025285|Drug|irinotecan hydrochloride|
5816247|NCT00025285|Drug|thalidomide|
5816248|NCT00025272|Drug|carboplatin|
5816249|NCT00025272|Drug|etoposide|
5816250|NCT00025272|Drug|topotecan hydrochloride|
5816251|NCT00025272|Radiation|radiation therapy|
5816252|NCT00025259|Biological|Bleomycin Sulfate|Given IV or SC
5816253|NCT00025259|Drug|Cisplatin|Given IV
5816254|NCT00025259|Drug|Cyclophosphamide|Given IV
5816255|NCT00025259|Drug|Cytarabine|Given IV
5816256|NCT00025259|Drug|Dexamethasone|Given IV
5816257|NCT00025259|Drug|Doxorubicin Hydrochloride|Given IV
5816258|NCT00025259|Drug|Etoposide|Given IV
5816259|NCT00025259|Biological|Filgrastim|Given SC
5816260|NCT00025259|Radiation|Involved-Field Radiation Therapy|Undergo IFRT
5816261|NCT00025259|Drug|Prednisone|Given orally
5816262|NCT00025259|Drug|Vincristine Sulfate Liposome|Given IV
5816263|NCT00025246|Drug|imatinib mesylate|Given orally
5816264|NCT00025246|Other|laboratory biomarker analysis|Correlative studies
5816265|NCT00025233|Biological|bevacizumab|Given IV
5816266|NCT00025233|Other|laboratory biomarker analysis|Correlative studies
5816267|NCT00025220|Drug|Thalidomide|Given PO
5816268|NCT00025220|Other|Laboratory Biomarker Analysis|Correlative studies
5816269|NCT00025194|Drug|estramustine phosphate sodium|
5816270|NCT00025194|Drug|ixabepilone|
5816271|NCT00025181|Biological|MART-1 antigen|
5816272|NCT00025181|Biological|gp100 antigen|
5816273|NCT00025181|Biological|incomplete Freund's adjuvant|
5816274|NCT00025181|Biological|ipilimumab|
5816275|NCT00025181|Biological|tyrosinase peptide|
5816276|NCT00025181|Procedure|adjuvant therapy|
5816277|NCT00025168|Drug|gemcitabine hydrochloride|
5816278|NCT00025168|Drug|irinotecan hydrochloride|
5816279|NCT00025168|Radiation|radiation therapy|
5816280|NCT00025155|Drug|ixabepilone|Given IV
5816290|NCT00025103|Drug|doxorubicin hydrochloride|
5816291|NCT00025103|Drug|etoposide|
5816292|NCT00025103|Drug|melphalan|
5816293|NCT00025103|Drug|vincristine sulfate|
5816294|NCT00025103|Procedure|autologous bone marrow transplantation|
5816295|NCT00025103|Procedure|conventional surgery|
5816296|NCT00025103|Procedure|peripheral blood stem cell transplantation|
5816297|NCT00025103|Radiation|radiation therapy|
5816298|NCT00025090|Drug|cisplatin|
5816299|NCT00025090|Drug|fluorouracil|
5816300|NCT00025090|Drug|mitomycin C|
5816301|NCT00025090|Radiation|radiation therapy|
5816302|NCT00025077|Biological|filgrastim|
5816303|NCT00025077|Drug|carboplatin|
5816304|NCT00025077|Drug|cyclophosphamide|
5816305|NCT00025077|Drug|thiotepa|
5816306|NCT00025077|Procedure|conventional surgery|
5816307|NCT00025077|Procedure|peripheral blood stem cell transplantation|
5816308|NCT00025077|Radiation|radiation therapy|
5816309|NCT00025064|Biological|bleomycin sulfate|
5816310|NCT00025064|Drug|chlorambucil|
5816311|NCT00025064|Drug|cisplatin|
5816312|NCT00025064|Drug|dacarbazine|
5816313|NCT00025064|Drug|doxorubicin hydrochloride|
5816314|NCT00025064|Drug|etoposide|
5816315|NCT00025064|Drug|ifosfamide|
5816316|NCT00025064|Drug|melphalan|
5816317|NCT00025064|Drug|prednisolone|
5816318|NCT00025064|Drug|procarbazine hydrochloride|
5816319|NCT00025064|Drug|vinblastine sulfate|
5816320|NCT00025064|Drug|vincristine sulfate|
5816321|NCT00025064|Procedure|peripheral blood stem cell transplantation|
5816322|NCT00025064|Radiation|radiation therapy|
5816323|NCT00025051|Drug|celecoxib|
5816324|NCT00025051|Procedure|anti-cytokine therapy|
5816325|NCT00025051|Procedure|antiangiogenesis therapy|
5816326|NCT00025051|Procedure|biological therapy|
5816327|NCT00025051|Procedure|cancer prevention intervention|
5816328|NCT00025051|Procedure|chemoprevention of cancer|
5816329|NCT00025051|Procedure|growth factor antagonist therapy|
5816330|NCT00025038|Drug|tipifarnib|Given orally
5816331|NCT00025038|Drug|isotretinoin|Given orally
5816332|NCT00025038|Drug|fludarabine phosphate|Given IV
5816333|NCT00025038|Drug|cytarabine|Given IV
5816334|NCT00025038|Radiation|radiation therapy|Undergo total body irradiation
5816335|NCT00025038|Drug|cyclophosphamide|Given IV
5816336|NCT00025038|Biological|anti-thymocyte globulin|Given IV
5816337|NCT00025038|Procedure|allogeneic bone marrow transplantation|Undergo allogeneic bone marrow transplant
5816338|NCT00025038|Procedure|double-unit umbilical cord blood transplantation|
5816339|NCT00025038|Procedure|umbilical cord blood transplantation|Undergo allogeneic cord blood transplant
5816340|NCT00025038|Other|laboratory biomarker analysis|Correlative studies
5816341|NCT00025025|Other|sample testing|
5816342|NCT00024466|Biological|GVAX|
5816343|NCT00024466|Procedure|Autologous transplant|
5816344|NCT00024453|Biological|teicoplanin|
5816345|NCT00024440|Biological|filgrastim|
5816346|NCT00024440|Biological|oblimersen sodium|
5816347|NCT00024440|Drug|cyclophosphamide|
5816348|NCT00024440|Drug|fludarabine phosphate|
5816349|NCT00024427|Drug|fluorouracil|High dose 5-FU
5816350|NCT00024427|Drug|gemcitabine hydrochloride|Normal dose to treat pancreatic cancer
5816351|NCT00024427|Drug|triacetyluridine|6 grams (12 tablets)
5816352|NCT00024414|Drug|DHA-paclitaxel|
5816353|NCT00024375|Drug|DHA-paclitaxel|
5816354|NCT00024349|Drug|fluorouracil|
5816355|NCT00024349|Drug|mitomycin C|
5816356|NCT00024349|Radiation|radiation therapy|
5816357|NCT00024336|Drug|tamoxifen citrate|
5816358|NCT00024336|Radiation|radiation therapy|
5816359|NCT00024297|Drug|warfarin|
5816360|NCT00024284|Drug|carboplatin|
5816361|NCT00024284|Drug|irinotecan hydrochloride|
5816362|NCT00024271|Biological|recombinant interferon gamma|
5816363|NCT00024271|Drug|cisplatin|
5816364|NCT00024271|Drug|doxorubicin hydrochloride|
5816365|NCT00024271|Drug|gemcitabine hydrochloride|
5816366|NCT00024271|Drug|mitomycin C|
5816367|NCT00024271|Procedure|conventional surgery|
5816368|NCT00024271|Procedure|hyperthermia treatment|
5816369|NCT00024271|Radiation|radiation therapy|
5816370|NCT00024258|Drug|arsenic trioxide|
5816371|NCT00024245|Drug|pralatrexate|
5816372|NCT00024245|Drug|probenecid|
5816373|NCT00024232|Biological|monoclonal antibody huJ591|
5816374|NCT00024193|Biological|filgrastim|
5816375|NCT00024193|Drug|busulfan|
5816376|NCT00024193|Drug|cisplatin|
5816377|NCT00024193|Drug|cyclophosphamide|
5816378|NCT00024193|Drug|doxorubicin hydrochloride|
5816379|NCT00024193|Drug|etoposide|
5816380|NCT00024193|Drug|melphalan|
5816381|NCT00024193|Drug|vincristine sulfate|
5816382|NCT00024193|Procedure|conventional surgery|
5816383|NCT00024193|Procedure|peripheral blood stem cell transplantation|
5816384|NCT00024180|Drug|romidepsin|
5816385|NCT00024167|Drug|Docetaxel|75 mg/m2 intravenous piggyback (IVPB) over 1 hour, Day 1, every 3 weeks.
5816386|NCT00024167|Drug|Doxorubicin hydrochloride|20 mg/m2 IV, day 1 on Weeks 1, 3, 5
5816387|NCT00024167|Drug|Estramustine phosphate sodium|140 mg orally 3 x day, Days 1 through 7 on Weeks 2, 4, 6
5816388|NCT00024167|Drug|Ketoconazole|400 mg orally (po) 3 x day, Days 1 through 7
5816389|NCT00024167|Drug|Prednisone|5 mg orally 2 x daily, weeks 1-14
5816390|NCT00024167|Drug|Vinblastine|4 mg/m2 IVPB, Day 1 on Weeks 2, 4, 6
5816391|NCT00024167|Radiation|Strontium chloride Sr 89|One dose (4 mCi total dose) IV
5816485|NCT00022737|Drug|methotrexate|Given IT, IV, and orally
5816392|NCT00024167|Drug|Dexamethasone|4 mg is given orally at 12 and 1 hours before and 12 hours after docetaxel.
5816393|NCT00024154|Biological|trastuzumab|Given IV
5816394|NCT00024154|Drug|gefitinib|Given orally
5816395|NCT00024154|Other|laboratory biomarker analysis|Correlative studies
5816396|NCT00024115|Drug|BL22 immunotoxin|
5816397|NCT00024115|Procedure|antibody therapy|
5816398|NCT00024115|Procedure|biological response modifier therapy|
5816399|NCT00024115|Procedure|immunotoxin therapy|
5816400|NCT00024102|Drug|Standard Treatment|Cyclophosphamide 100 mg/sq m PO d 1-14 + MTX 40 mg/sq m IV push d 1 & 8 and 5-FU 600 mg/sq m IV push d 1 & 8 q 28 days for 6 cycles OR doxorubicin 60 mg/sq m IV d 1 + cyclophosphamide 600 mg/sq m IV d 1 q 21 d for 4 cycles
5816401|NCT00024102|Drug|capecitabine|2000 mg/sq m PO d 1-14, 7 day rest then repeat for a total of 6 cycles
5816402|NCT00024089|Drug|gefitinib|
5816403|NCT00024076|Procedure|radiofrequency ablation|
5816404|NCT00024050|Drug|busulfan|
5816405|NCT00024050|Drug|cyclophosphamide|
5816406|NCT00024050|Drug|cyclosporine|
5816407|NCT00024050|Drug|methotrexate|
5816408|NCT00024050|Procedure|allogeneic bone marrow transplantation|
5816409|NCT00024050|Procedure|peripheral blood stem cell transplantation|
5816410|NCT00023998|Drug|doxorubicin hydrochloride|Given IV
5816411|NCT00023998|Drug|cisplatin|Given IV
5816412|NCT00023998|Drug|methotrexate|Given IV
5816413|NCT00023998|Drug|leucovorin calcium|Given IV or orally
5816414|NCT00023998|Biological|filgrastim|Given IV
5816415|NCT00023998|Procedure|therapeutic conventional surgery|Undergo resection
5816416|NCT00023998|Radiation|radiation therapy|Undergo radiotherapy
5816417|NCT00023998|Drug|etoposide|Given IV
5816418|NCT00023998|Drug|ifosfamide|Given IV
5816419|NCT00023998|Biological|trastuzumab|Given IV
5816420|NCT00023998|Other|laboratory biomarker analysis|Correlative studies
5816421|NCT00023985|Biological|autologous tumor cell vaccine|
5816422|NCT00023985|Biological|therapeutic autologous dendritic cells|
5816423|NCT00023985|Procedure|conventional surgery|
5816424|NCT00023972|Drug|exatecan mesylate|
5816425|NCT00023972|Drug|gemcitabine hydrochloride|
5816426|NCT00023959|Drug|hydroxyurea|Given orally
5816427|NCT00023959|Drug|fluorouracil|Given IV
5816428|NCT00023959|Biological|bevacizumab|Given IV
5816429|NCT00023959|Radiation|radiation therapy|Undergo radiotherapy
5816430|NCT00023959|Biological|filgrastim|Given subcutaneously
5816431|NCT00023959|Other|laboratory biomarker analysis|Correlative studies
5816432|NCT00023946|Drug|ixabepilone|Given IV
5816433|NCT00023946|Other|laboratory biomarker analysis|Correlative studies
5816434|NCT00023920|Biological|bevacizumab|Given IV
5816435|NCT00023920|Drug|idarubicin|Given IV
5816436|NCT00023920|Drug|cytarabine|Given SC
5816437|NCT00023894|Drug|alvocidib|
5816438|NCT00023881|Drug|bortezomib|
5816439|NCT00023855|Drug|bortezomib|
5816440|NCT00023855|Drug|doxorubicin hydrochloride|
5816441|NCT00023842|Biological|BCG vaccine|
5816442|NCT00023842|Drug|mitomycin C|
5816443|NCT00023842|Procedure|adjuvant therapy|
5816444|NCT00023842|Procedure|conventional surgery|
5816445|NCT00023829|Drug|bicalutamide|
5816446|NCT00023829|Drug|flutamide|
5816447|NCT00023829|Drug|releasing hormone agonist therapy|
5816448|NCT00023829|Procedure|adjuvant therapy|
5816449|NCT00023829|Radiation|radiation therapy|
5816450|NCT00023790|Drug|silicon phthalocyanine 4|Patients receive silicon phthalocyanine 4 (Pc 4) IV over 2 hours on day 1 followed by light therapy over 30-60 minutes on day 2. Treatment repeats in 6 weeks for a total of 2 courses in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of Pc 4.
5816451|NCT00023777|Biological|filgrastim|induction: 5 mcg/kg/d IV or SC starting apx day 15
5816452|NCT00023777|Biological|sargramostim|induction: 250 mcg/m2/d IV or SC starting apx day 1
5816453|NCT00023777|Drug|cytarabine|ind: 200 mg/m2/d continuous IV days 1-7 consol: 200 mg/m2/d continuous IV days 1-5
5816454|NCT00023777|Drug|daunorubicin hydrochloride|ind and consol: 45 mg/m2/d continuous IV days 1-3
5816455|NCT00023764|Drug|bortezomib|Given IV
5816456|NCT00023751|Drug|fluorouracil|
5816457|NCT00023751|Drug|leucovorin calcium|
5816458|NCT00023751|Procedure|conventional surgery|
5816459|NCT00023751|Radiation|radiation therapy|
5816460|NCT00023712|Drug|bortezomib|Given IV
5816461|NCT00023712|Other|laboratory biomarker analysis|Correlative studies
5816462|NCT00023712|Other|pharmacological study|Correlative studies
5816463|NCT00023686|Procedure|surgery|
5816464|NCT00023686|Radiation|radiation|
5816465|NCT00023660|Drug|celecoxib|
5816466|NCT00023660|Drug|cisplatin|
5816467|NCT00023660|Drug|fluorouracil|
5816468|NCT00023660|Radiation|brachytherapy|
5816469|NCT00023660|Radiation|radiation therapy|
5816470|NCT00023634|Biological|KLH|100 mcg w/EGFRvIII
5816471|NCT00023634|Biological|GMCSF|arm 1: 100 mcg w/EGFRvIII
5816472|NCT00023621|Drug|celecoxib|
5816473|NCT00022737|Biological|filgrastim|Given SC
5816474|NCT00022737|Drug|asparaginase|Given IM
5816475|NCT00022737|Drug|cyclophosphamide|Given IV
5816476|NCT00022737|Drug|cyclosporine|Given IV
5816477|NCT00022737|Drug|cytarabine|Given IT and IV
5816478|NCT00022737|Drug|daunorubicin hydrochloride|Given IV
5816479|NCT00022737|Drug|dexamethasone|Given orally
5816480|NCT00022737|Drug|etoposide|Given IV
5816481|NCT00022737|Drug|ifosfamide|Given IV
5816482|NCT00022737|Drug|imatinib mesylate|Given orally
5816483|NCT00022737|Drug|leucovorin calcium|Given IV or orally
5816484|NCT00022737|Drug|mercaptopurine tablet|Given orally
5816486|NCT00022737|Drug|pegaspargase|Given IM
5816487|NCT00022737|Drug|vincristine sulfate|Given IV
5816488|NCT00022737|Procedure|allogeneic bone marrow transplantation|Undergo allogeneic bone marrow, peripheral blood stem cell, or umbilical cord blood transplantation
5816489|NCT00022737|Procedure|peripheral blood stem cell transplantation|Undergo allogeneic bone marrow, peripheral blood stem cell, or umbilical cord blood transplantation
5816490|NCT00022737|Procedure|umbilical cord blood transplantation|Undergo allogeneic bone marrow, peripheral blood stem cell, or umbilical cord blood transplantation
5816491|NCT00022737|Radiation|radiation therapy|Undergo radiation therapy
5816492|NCT00022724|Drug|temsirolimus|
5816493|NCT00022711|Drug|temozolomide|150 mg/m2/day Repeat cycles every 28 days following first daily dose of each cycle until toxicity or disease progression for a maximum of six months
5816494|NCT00022698|Drug|Capecitabine|
5816495|NCT00022698|Drug|Irinotecan|
5816496|NCT00022685|Biological|epratuzumab|
5816497|NCT00022672|Drug|trastuzumab (Herceptin®)|4mg/kg iv loading dose, followed by 2mg/kg iv weekly
5816498|NCT00022672|Drug|anastrazole (Arimidex®)|1 mg tablet taken orally daily
5816499|NCT00022659|Biological|bevacizumab|Given IV
5816500|NCT00022659|Other|laboratory biomarker analysis|Correlative studies
5816501|NCT00022646|Drug|gemcitabine hydrochloride|
5816502|NCT00022646|Drug|pemetrexed disodium|
5816503|NCT00022633|Drug|gemcitabine hydrochloride|
5816504|NCT00022633|Drug|paclitaxel|
5816505|NCT00022620|Drug|paclitaxel|
5816506|NCT00022607|Biological|bevacizumab|
5816507|NCT00022607|Drug|thalidomide|
5816508|NCT00022581|Drug|thalidomide|Given orally
5816509|NCT00022581|Other|laboratory biomarker analysis|Correlative studies
5816510|NCT00022568|Biological|recombinant vaccinia-TRICOM vaccine|
5816511|NCT00022555|Drug|bryostatin 1|Given IV
5816512|NCT00022555|Drug|vincristine sulfate|Given IV
5816513|NCT00022516|Drug|Cyclophosphamide|50 mg/day orally continuously for 1 year
5816514|NCT00022516|Drug|Methotrexate|2.5 mg twice/day orally days 1 and 2 of every week for 1 year
5816515|NCT00022490|Drug|cytarabine|Once daily subcutaneous injection of Ara-C (Cytarabine) at a dose of 20 mg (10 mg or 5 mg if they have been dose reduced) per square meter of calculated body surface area, on days 15-28 of each sequential 28 day cycle
5816516|NCT00022490|Drug|imatinib mesylate|Once daily oral administration of STI571 (Imatinib Mesylate) at a dose of 400 mg for 12 months.
5816517|NCT00022464|Drug|temsirolimus|
5816518|NCT00022451|Drug|tipifarnib|
5816519|NCT00022438|Biological|aldesleukin|
5816520|NCT00022438|Biological|incomplete Freund's adjuvant|
5816521|NCT00022438|Biological|recombinant tyrosinase-related protein-2|
5816522|NCT00022425|Drug|perillyl alcohol|
5816523|NCT00022412|Dietary Supplement|doxercalciferol|Arm 1: Patients receive doxercalciferol once daily for 28 days. Patients then undergo prostatectomy.
5816524|NCT00022412|Procedure|conventional surgery|Procedure: Prostatectomy for prostate cancer
5816525|NCT00022399|Drug|celecoxib|400mg PO twice daily for 4-6 weeks up to 8 hours prior to prostatectomy.
5816526|NCT00022399|Drug|Placebos|Placebo PO twice daily for 4-6 weeks up to 8 hours prior to prostatectomy.
5816527|NCT00022334|Biological|AFP|Increasing doses of AFP will be given to groups of 3 intradermally. Subjects will receive 3 biweekly vaccinations. At least 2 patients at a given dose must have received their complete 3 vaccination schedule with a 30 day observation period after the last vaccination before a higher dose is initiated.
5816528|NCT00022295|Drug|idronoxil|
5816529|NCT00022230|Biological|aldesleukin|
5816530|NCT00022230|Biological|filgrastim|
5816531|NCT00022230|Biological|sargramostim|
5816532|NCT00022230|Biological|therapeutic autologous lymphocytes|
5816533|NCT00022230|Drug|cyclophosphamide|
5816534|NCT00022230|Drug|doxorubicin hydrochloride|
5816535|NCT00022230|Drug|paclitaxel|
5816536|NCT00022191|Drug|cisplatin|
5816537|NCT00022191|Drug|gemcitabine hydrochloride|
5816538|NCT00022191|Drug|paclitaxel|
5816539|NCT00022152|Drug|vinorelbine tartrate|
5816540|NCT00022126|Drug|asparaginase|
5816541|NCT00022126|Drug|cyclophosphamide|
5816542|NCT00022126|Drug|cyclosporine|
5816543|NCT00022126|Drug|cytarabine|
5816544|NCT00022126|Drug|daunorubicin hydrochloride|
5816545|NCT00022126|Drug|dexamethasone|
5816546|NCT00022126|Drug|doxorubicin hydrochloride|
5816547|NCT00022126|Drug|mercaptopurine|
5816548|NCT00022126|Drug|methotrexate|
5816549|NCT00022126|Drug|methylprednisolone|
5816550|NCT00022126|Drug|pegaspargase|
5816551|NCT00022126|Drug|thioguanine|
5816552|NCT00022126|Drug|vincristine sulfate|
5816553|NCT00022126|Procedure|allogeneic bone marrow transplantation|
5816554|NCT00022126|Radiation|radiation therapy|
5816555|NCT00022113|Drug|cilengitide|Given IV
5816556|NCT00022113|Other|pharmacological study|Correlative studies
5816557|NCT00022113|Other|laboratory biomarker analysis|Correlative studies
5816558|NCT00022087|Dietary Supplement|calcium salts|1000 mg PO per day
5816559|NCT00022087|Dietary Supplement|cholecalciferol|400 IU PO per day
5816560|NCT00022087|Drug|zoledronic acid|4 mg IV infusion q 3 months, months 1-24 in Zoledronic acid initial tx arm and months 13-36 in calcium + vit D initial tx arm
5816561|NCT00022074|Drug|gabapentin|
5816562|NCT00022074|Procedure|quality-of-life assessment|
5816563|NCT00022048|Biological|bevacizumab|
5816564|NCT00022035|Biological|trivalent influenza vaccine|
5816565|NCT00022022|Drug|docetaxel|
5816566|NCT00022022|Procedure|quality-of-life assessment|
5816567|NCT00021450|Drug|bicalutamide|
5816568|NCT00021450|Drug|goserelin acetate|
5816569|NCT00021450|Procedure|adjuvant therapy|
5816570|NCT00021450|Radiation|radiation therapy|
5816571|NCT00021424|Biological|recombinant fowlpox-TRICOM vaccine|
5816575|NCT00021320|Procedure|conventional surgery|
5816576|NCT00021320|Procedure|neoadjuvant therapy|
5816577|NCT00021320|Radiation|radiation therapy|
5816578|NCT00021255|Drug|Doxorubicin|
5816579|NCT00021255|Drug|Cyclophosphamide|
5816580|NCT00021255|Drug|Docetaxel|
5816581|NCT00021255|Drug|Herceptin|
5816582|NCT00021255|Drug|Carboplatin|
5816583|NCT00021242|Drug|docetaxel|Continuous IV infusion
5816584|NCT00021229|Drug|imatinib mesylate|"Phase 1 Stratum I: Starting dose level of 350 mg/m2/day every 28 days X 13 courses (dose escalation)~Phase I Stratum IIA: Starting dose level of 465 mg/m2/day every 28 days X 13 courses (dose escalation)~Phase I Stratum IIB: Starting dose level of 465 mg/m2/day every 28 days X 13 courses (dose escalation)~Phase II: Phase I Stratum I determined dose (Maximum tolerated dose) every 28 days X 13 courses."
5816585|NCT00021229|Radiation|local irradiation therapy|"Phase I Stratum I: Total dose of 5580 cGy using conventional or conformal volume-based delivery techniques once daily, 5 days/week for six weeks prior to receiving imatinib.~Phase II: Total dose of 5580 cGy using conventional or conformal volume-based delivery techniques once daily, 5 days/week for six weeks prior to receiving imatinib."
5816586|NCT00021216|Drug|bortezomib|Given IV
5816587|NCT00021216|Other|laboratory biomarker analysis|Correlative studies
5816588|NCT00021216|Other|pharmacological study|Correlative studies
5816589|NCT00021164|Biological|aldesleukin|
5816590|NCT00021164|Biological|incomplete Freund's adjuvant|
5816591|NCT00021164|Biological|telomerase: 540-548 peptide vaccine|
5816592|NCT00021125|Procedure|adjuvant therapy|
5816593|NCT00021125|Radiation|radiation therapy|
5816594|NCT00021112|Drug|cisplatin|
5816595|NCT00021112|Drug|etoposide|
5816596|NCT00021112|Procedure|conventional surgery|
5816597|NCT00021112|Radiation|radiation therapy|
5816598|NCT00021073|Drug|alvocidib|Given IV
5816599|NCT00021073|Drug|leucovorin calcium|Given IV
5816600|NCT00021073|Drug|fluorouracil|Given IV
5816601|NCT00021073|Drug|irinotecan hydrochloride|Given IV
5816602|NCT00021060|Drug|paclitaxel|Given IV
5816603|NCT00021060|Drug|carboplatin|Given IV
5816604|NCT00021060|Biological|bevacizumab|Given IV
5816605|NCT00021060|Other|laboratory biomarker analysis|Correlative studies
5816606|NCT00021047|Drug|capecitabine|
5816607|NCT00021047|Drug|carboplatin|
5816608|NCT00021047|Drug|epirubicin hydrochloride|
5816609|NCT00020995|Procedure|therapeutic dietary intervention|
5816610|NCT00020969|Drug|arsenic trioxide|
5816611|NCT00020943|Biological|filgrastim|5 ug/kg subQ daily day 4 until ANC >10,000 (or ANC> 5000 2X)Tx 1, 2, 4 10 ug/kg subQ daily day 14 until completion of PBSC collection Tx 3
5816612|NCT00020943|Biological|rituximab|375 mg/sq m IV infusion at , or = 400 mg/hr day 1 Tx 1, 2, days 5 & 12 Tx 3, and weekly for 2 doses Tx 5
5816613|NCT00020943|Drug|carmustine|15 mg/kg IV infusion over 2 hours Day 6, Tx 4
5816614|NCT00020943|Drug|cyclophosphamide|2000 mg/sq m IV infusion over 2 hours Day 3, Tx 1 & 2 100 mg/kg IV infusion over 2 hours Day 2, Tx 4
5816615|NCT00020943|Drug|cytarabine|2000 mg/sq m IV infusion BID over 2 hours x 8 doses Days 1-4, Tx 3
5816616|NCT00020943|Drug|doxorubicin hydrochloride|50 mg/sq m IVP Day 3, Tx 1& 2
5816617|NCT00020943|Drug|etoposide|40 mg/kg total dose continuous IV infusion over 96 hours Days 1-4, Tx 3
5816618|NCT00020943|Drug|leucovorin calcium|50 mg/sq m IV infusion q 6 hours x 3 doses after MTX, then 10 mg/sq m IV/PO q 6 hrs until MTX levels <0.05 uM, Tx 1 & 2
5816619|NCT00020943|Drug|methotrexate|300 mg/sq m IV infusion over 4 hrs Day 2 Tx 1 & 2
5816620|NCT00020943|Drug|prednisone|100 mg/sq m PO Days 3-7, Tx 1 & 2
5816621|NCT00020943|Drug|vincristine sulfate|1.4 mg/sq m IVP Day 3, Tx 1 & 2
5816622|NCT00020943|Procedure|peripheral blood stem cell transplantation|Stem cells collected during Tx 3 will be transfused follwing chemotx in Tx 4
5816623|NCT00020891|Procedure|computed tomography|
5816624|NCT00020891|Radiation|radiation therapy|
5816625|NCT00020878|Drug|celecoxib|Dosing will occur for a total of 6 months. 400 mg by mouth twice daily.
5816626|NCT00020852|Procedure|conventional surgery|
5816627|NCT00020852|Procedure|cryosurgery|
5816628|NCT00020839|Drug|temozolomide|
5816629|NCT00020839|Radiation|radiation therapy|
5816630|NCT00020826|Other|quality-of-life assessment|QLQ-C30 questionnaire administered. STO22 questionnaire administered.
5816631|NCT00020800|Biological|rituximab|
5816632|NCT00020800|Drug|fludarabine phosphate|
5816633|NCT00020761|Drug|irinotecan hydrochloride|"The course length is 3 weeks. Treatment will continue until one or more of criteria listed in the protocol are met.~Irinotecan 225 mg/m2 will be infused over 90 minutes every three weeks."
5816634|NCT00020761|Drug|paclitaxel|"The course length is 3 weeks. Treatment will continue until one or more of criteria listed in the protocol are met.~Paclitaxel 100 mg/m2 will be infused over three hours following irinotecan infusion every three weeks."
5816635|NCT00020748|Drug|epirubicin hydrochloride|
5816636|NCT00020748|Drug|irinotecan hydrochloride|
5816637|NCT00020735|Drug|toremifene|
5816638|NCT00020735|Procedure|conventional surgery|
5816639|NCT00020735|Procedure|neoadjuvant therapy|
5816640|NCT00020722|Biological|therapeutic autologous lymphocytes|"Immediately after pheresis, the lymphocytes will be activated with soluble monoclonal anti-CD3 antibody (OKT3) which cross-links the CD3 receptors on T cells and activates T cells.~The time for ATC infusions will vary from patient to patient, but the infusion rate will be based on the rate calculated from the endotoxin level in the cell product. All patients will be observed for at least 1 hr after an infusion."
5816722|NCT00019994|Biological|MART-1 antigen|
5816723|NCT00019994|Biological|aldesleukin|
5816724|NCT00019994|Biological|gp100 antigen|
5816725|NCT00019994|Biological|incomplete Freund's adjuvant|
5816726|NCT00019955|Procedure|laparoscopic surgery|
5816727|NCT00019955|Procedure|radiofrequency ablation|
5816728|NCT00019955|Procedure|thermal ablation therapy|
5816729|NCT00019929|Biological|mutant p53 peptide pulsed dendritic cell vaccine|
5816641|NCT00020722|Drug|Ifosfamide, carboplatin, and etoposide (ICE) regimen|"Ifosfamide 2,500 mg/m2 given IV daily on day -8, -7, -6, -5, -4, and -3 prior to PBSCT. Ifosfamide 2,500 mg/m2 infused IV over 1 hour (hour 0-1) on days -8 to -3 for a total dose of 15,000 mg/m2.~Mesna will be administered per BMT Standard of Care Guideline at a dose of 25% of the total Ifosfamide dose 30 minutes prior to and then 3, 6, and 9 hours after ifosfamide daily on days -8, -7, -6, -5, -4, and -3 prior to PBSCT for a total dose of 2500 mg/m2.~Carboplatin at a dose of 250 mg/m2 will be given daily on days -8, -7, -6, -5, -4, and -3 prior to PBSCT for a total dose of 1500 mg/m2.~VP-16 (etoposide) at a dose of 200 mg/m2 will be given IV on days -8, -7, -6, -5, -4 and -3. The total dose of VP-16 given prior to PBSCT will be 2,400 mg/m2. VP-16 will be given 200 mg/m2"
5816642|NCT00020722|Drug|Cyclophosphamide, Thiotepa, Carboplatin (CTC) or STAMP V (CTC)|"Cyclophosphamide will be given at a dose of 2000 mg/m2 in NS IV over one hour daily on days -4, -3, and -2 (total = 6000 mg/m2).~Thiotepa will be given at a dose of 167 mg/m2 in NS IV over one hour daily on days -4, -3, -2 (total = 500 mg/m2) as the preparative regimen followed by PBSCT on day 0.~Carboplatin will be given at a dose of 267 mg/m2 in D5W IV over one hour daily on days -4, -3, and -2.~Mesna will be administered per BMT Standard of Care Guidelines at a dose of 25% of the total cyclophosphamide dose 30 minutes prior to and then 3, 6, and 9 hours after cyclophosphamide daily on days -4, -3, and -2 prior to PBSCT for a total of 2000mg/m2."
5816643|NCT00020722|Procedure|Leukapheresis|Peripheral blood mononuclear cells (PBMC) will be collected by leukapheresis (for generation of ATC) prior to or post G-CSF (16 ug/kg/day) priming for collecting stem cells.
5816644|NCT00020722|Procedure|peripheral blood stem cell transplantation (PBSCT)|Will be collected either before or after peripheral blood stem cell collection for stem cell transplant.
5816645|NCT00020709|Drug|cisplatin|Given IV
5816646|NCT00020709|Drug|docetaxel|Given IV
5816647|NCT00020709|Drug|etoposide|Given IV
5816648|NCT00020709|Drug|gefitinib|Given orally
5816649|NCT00020709|Radiation|radiation therapy|Undergo radiation therapy
5816650|NCT00020709|Other|placebo|Given orally
5816651|NCT00020683|Drug|incyclinide|High dose given orally
5816652|NCT00020683|Drug|incyclinide|Low dose given orally
5816653|NCT00020683|Other|laboratory biomarker analysis|Correlative studies
5816654|NCT00020670|Biological|CD 40|
5816655|NCT00020657|Drug|dolasetron mesylate|
5816656|NCT00020657|Drug|granisetron hydrochloride|
5816657|NCT00020657|Drug|ondansetron|
5816658|NCT00020657|Drug|prochlorperazine|
5816659|NCT00020657|Procedure|quality-of-life assessment|
5816660|NCT00020644|Drug|gemcitabine hydrochloride|
5816661|NCT00020631|Drug|pirfenidone|
5816662|NCT00020579|Drug|entinostat|
5816663|NCT00020566|Biological|dactinomycin|Given IV
5816664|NCT00020566|Drug|busulfan|Given orally and IV
5816665|NCT00020566|Drug|doxorubicin hydrochloride|Given IV
5816666|NCT00020566|Drug|etoposide|Given IV
5816667|NCT00020566|Drug|ifosfamide|Given IV
5816668|NCT00020566|Drug|melphalan|Given orally and IV
5816669|NCT00020566|Drug|vincristine sulfate|Given IV
5816670|NCT00020566|Procedure|autologous hematopoietic stem cell transplantation|Given IV
5816671|NCT00020566|Procedure|conventional surgery|Given to patients deemed to require it
5816672|NCT00020566|Radiation|radiation therapy|Given to patients deemed to require it
5816673|NCT00020527|Drug|caspofungin acetate|
5816674|NCT00020501|Drug|FOLFIRI regimen|
5816675|NCT00020501|Drug|floxuridine|
5816676|NCT00020501|Drug|fluorouracil|
5816677|NCT00020501|Drug|irinotecan hydrochloride|
5816678|NCT00020501|Drug|leucovorin calcium|
5816679|NCT00020501|Drug|melphalan|
5816680|NCT00020501|Procedure|hyperthermia treatment|
5816681|NCT00020488|Drug|FOLFIRI regimen|
5816682|NCT00020488|Drug|fluorouracil|
5816683|NCT00020488|Drug|irinotecan hydrochloride|
5816684|NCT00020488|Drug|leucovorin calcium|
5816685|NCT00020449|Biological|recombinant interleukin-12|
5816686|NCT00020449|Drug|paclitaxel|
5816687|NCT00020449|Drug|pegylated liposomal doxorubicin hydrochloride|
5816688|NCT00020410|Biological|filgrastim|
5816689|NCT00020410|Procedure|peripheral blood stem cell transplantation|
5816690|NCT00020410|Radiation|yttrium Y 90 monoclonal antibody B3|
5816691|NCT00020397|Biological|NY-ESO-1 peptide vaccine|
5816692|NCT00020397|Biological|aldesleukin|
5816693|NCT00020358|Biological|aldesleukin|
5816694|NCT00020358|Biological|gp100 antigen|
5816695|NCT00020358|Biological|incomplete Freund's adjuvant|
5816696|NCT00020358|Biological|tyrosinase peptide|
5816697|NCT00020332|Drug|alvocidib|
5816698|NCT00020332|Drug|docetaxel|
5816699|NCT00020254|Biological|aldesleukin|
5816700|NCT00020254|Biological|recombinant fowlpox-prostate specific antigen vaccine|
5816701|NCT00020254|Biological|recombinant vaccinia prostate-specific antigen vaccine|
5816702|NCT00020254|Biological|recombinant vaccinia-B7.1 vaccine|
5816703|NCT00020254|Biological|sargramostim|
5816704|NCT00020254|Drug|nilutamide|
5816705|NCT00020189|Drug|acetylsalicylic acid|
5816706|NCT00020189|Drug|alvocidib|
5816707|NCT00020189|Drug|clopidogrel bisulfate|
5816708|NCT00020176|Biological|filgrastim|
5816709|NCT00020176|Biological|therapeutic allogeneic lymphocytes|
5816710|NCT00020176|Drug|cyclophosphamide|
5816711|NCT00020176|Drug|cyclosporine|
5816712|NCT00020176|Drug|fludarabine phosphate|
5816713|NCT00020176|Procedure|peripheral blood stem cell transplantation|
5816714|NCT00020150|Drug|O6-benzylguanine|
5816715|NCT00020150|Drug|temozolomide|
5816716|NCT00020124|Drug|doxorubicin hydrochloride|
5816717|NCT00020111|Drug|arsenic trioxide|
5816718|NCT00020072|Other|laboratory biomarker analysis|
5816719|NCT00020007|Drug|isolated perfusion|
5816720|NCT00020007|Drug|paclitaxel|
5816721|NCT00020007|Procedure|hyperthermia treatment|
5816730|NCT00019929|Procedure|adjuvant therapy|
5816731|NCT00019916|Biological|aldesleukin|
5816732|NCT00019916|Biological|p53 peptide vaccine|
5816733|NCT00019916|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5816734|NCT00019864|Biological|filgrastim|
5816735|NCT00019864|Drug|cisplatin|
5816736|NCT00019864|Drug|dexrazoxane hydrochloride|
5816737|NCT00019864|Drug|doxorubicin hydrochloride|
5816738|NCT00019864|Drug|leucovorin calcium|
5816739|NCT00019864|Drug|methotrexate|
5816740|NCT00019864|Procedure|adjuvant therapy|
5816741|NCT00019864|Procedure|conventional surgery|
5816742|NCT00019864|Procedure|neoadjuvant therapy|
5816743|NCT00019838|Drug|7-hydroxystaurosporine|
5816744|NCT00019838|Drug|fludarabine phosphate|
5816745|NCT00019825|Drug|decitabine|
5816746|NCT00019812|Biological|trastuzumab|
5816747|NCT00019812|Drug|paclitaxel|
5816748|NCT00019786|Drug|isolated perfusion|
5816749|NCT00019786|Drug|melphalan|
5816750|NCT00019786|Procedure|conventional surgery|
5816751|NCT00019773|Drug|capecitabine|
5816752|NCT00019773|Drug|oxaliplatin|
5816753|NCT00019747|Drug|thalidomide|oral thalidomide 100 mg at bedtime once daily for 4 weeks, then progresses to 200 mg at bedtime for 4 weeks, then progresses to 300 mg at bedtime (maintenance dose).
5816754|NCT00019747|Procedure|adjuvant therapy|Initial dose: 100 mg by mouth (po) every bedtime ( Q hs) for four weeks, then progress to 200 mg po Q hs for four weeks, then progress to maintenance dose: 300 mg po Q hs.
5816755|NCT00019747|Other|Placebo|oral placebo once daily
5816756|NCT00019708|Drug|tanespimycin|Given IV
5816757|NCT00019682|Biological|Aldesleukin|Given IV
5816758|NCT00019682|Biological|gp100 Antigen|Given SC
5816759|NCT00019682|Drug|Montanide ISA 51 VG|Given SC
5816760|NCT00019682|Other|Quality-of-Life Assessment|Ancillary studies
5816761|NCT00019682|Other|Questionnaire Administration|Ancillary studies
5816762|NCT00019682|Other|Laboratory Biomarker Analysis|Correlative studies
5816763|NCT00019669|Biological|aldesleukin|
5816764|NCT00019669|Biological|fowlpox virus vaccine vector|
5816765|NCT00019669|Biological|gp100 antigen|
5816766|NCT00019656|Drug|perifosine|
5816767|NCT00019604|Procedure|computed tomography|Scan to assess the effects of ablation.
5816768|NCT00019604|Procedure|magnetic resonance imaging|Imaging used to assess the effects of this ablative therapy on tumor vascular density.
5816769|NCT00019604|Procedure|positron emission tomography|Physiology based method of imaging disease based on uptake and metabolism of radiopharmaceutical by the tissues.
5816770|NCT00019604|Procedure|radiofrequency ablation|Radiofrequency ablation uses saline infusion into and out of needle/electrode through a closed system. More energy may be deposited without tissue-charring or gas vaporization.
5816771|NCT00019604|Procedure|radionuclide imaging|Imaging following injection of a radioactive material.
5816772|NCT00019604|Procedure|ultrasound imaging|An ultrasound (e.g. sound waves) is used to identify the lesion and needle placement.
5816773|NCT00019604|Radiation|fludeoxyglucose F 18 (FDG-PET)|FDG PET scans rely on metabolic changes to evaluate response to therapy.
5816774|NCT00019604|Radiation|gadopentetate dimeglumine|Food and Drug Administration approved contrast agent.
5816775|NCT00019591|Biological|aldesleukin|
5816776|NCT00019591|Biological|ras peptide cancer vaccine|
5816777|NCT00019591|Procedure|adjuvant therapy|
5816778|NCT00019565|Procedure|magnetic resonance imaging|
5816779|NCT00019565|Procedure|positron emission tomography|
5816780|NCT00019565|Radiation|fludeoxyglucose F 18|
5816781|NCT00019513|Drug|fluorouracil|
5816782|NCT00019513|Drug|gemcitabine hydrochloride|
5816783|NCT00019513|Drug|leucovorin calcium|
5816784|NCT00019487|Biological|aldesleukin|
5816785|NCT00019487|Biological|gp209-2M antigen|
5816786|NCT00019487|Biological|incomplete Freund's adjuvant|
5816787|NCT00019461|Drug|carboxyamidotriazole|
5816788|NCT00019461|Drug|chemotherapy|
5816789|NCT00019422|Drug|carboplatin|
5816790|NCT00019422|Drug|lobradimil|
5816791|NCT00019331|Biological|aldesleukin|
5816792|NCT00019331|Biological|ras peptide cancer vaccine|
5816793|NCT00019331|Biological|sargramostim|
5816794|NCT00019331|Drug|DetoxPC|
5816795|NCT00019227|Drug|pentetic acid calcium|
5816796|NCT00019227|Radiation|yttrium Y 90 daclizumab|
5816797|NCT00019214|Biological|MART-1 antigen|
5816798|NCT00019214|Biological|aldesleukin|
5816799|NCT00019214|Biological|gp100 antigen|
5816800|NCT00019201|Other|cytology specimen collection procedure|
5816801|NCT00019201|Other|immunohistochemistry staining method|
5816802|NCT00019201|Other|sputum cytology|
5816803|NCT00019201|Procedure|bronchoscopic and lung imaging studies|
5816804|NCT00019201|Procedure|bronchoscopy|
5816805|NCT00019201|Procedure|comparison of screening methods|
5816806|NCT00019201|Procedure|endoscopic biopsy|
5816807|NCT00019136|Biological|MOv-gamma chimeric receptor gene|
5816808|NCT00019136|Biological|aldesleukin|
5816809|NCT00019136|Biological|therapeutic allogeneic lymphocytes|
5816810|NCT00019110|Biological|human papillomavirus 16 E7 peptide|
5816811|NCT00019110|Biological|synthetic human papillomavirus 16 E6 peptide|
5816812|NCT00019032|Biological|monoclonal antibody Mik-beta-1|
5816813|NCT00019019|Drug|carboxyamidotriazole|
5816814|NCT00019019|Drug|paclitaxel|
5816815|NCT00018967|Drug|glucarpidase|
5816816|NCT00017602|Biological|oblimersen sodium|
5816817|NCT00017602|Drug|dexamethasone|
5816818|NCT00017589|Biological|oblimersen sodium|
5816819|NCT00017589|Drug|gemtuzumab ozogamicin|
5816820|NCT00017563|Drug|docetaxel|35 mg/m2 i.v. over 15 - 30 minutes will be administered immediately after the mitoxantrone on the same schedule.
5816821|NCT00017563|Drug|mitoxantrone hydrochloride|Initial dose will be 2 mg/m2 weekly for 3 of every 4 weeks. The dose will then be escalated as described in the dose escalation section up to a maximum dose of 6 mg/m2 weekly for 3 of every 4 weeks.
5816822|NCT00017563|Procedure|conventional surgery|Prostatectomy will be scheduled 2 - 4 weeks after the last dose of chemotherapy.
5816823|NCT00017550|Biological|anti-thymocyte globulin|
5816824|NCT00017524|Drug|pelitrexol|
5816825|NCT00017511|Drug|cevimeline hydrochloride|
5816826|NCT00017498|Drug|gemcitabine hydrochloride|
5816827|NCT00017485|Drug|HPPH|
5816828|NCT00017472|Biological|apolizumab|Given IV
5816829|NCT00017472|Other|laboratory biomarker analysis|Correlative studies
5816830|NCT00017472|Other|pharmacological study|Correlative studies
5816831|NCT00017381|Biological|rituximab|Given IV
5816832|NCT00017381|Drug|cyclophosphamide|Given IV
5816833|NCT00017381|Biological|filgrastim|Given SC
5816834|NCT00017381|Radiation|yttrium Y 90 ibritumomab tiuxetan|Given IV
5816835|NCT00017381|Procedure|peripheral blood stem cell transplantation|Undergo PBSCT
5816836|NCT00017355|Biological|filgrastim|
5816837|NCT00017355|Biological|therapeutic autologous dendritic cells|
5816838|NCT00017329|Drug|bortezomib|
5816839|NCT00017290|Biological|autologous immunoglobulin idiotype-KLH conjugate vaccine|
5816840|NCT00017290|Biological|keyhole limpet hemocyanin|
5816841|NCT00017290|Biological|sargramostim|
5816842|NCT00017290|Drug|cyclophosphamide|
5816843|NCT00017290|Drug|prednisone|
5816844|NCT00017290|Drug|vincristine sulfate|
5816845|NCT00017277|Biological|epoetin alfa|
5816846|NCT00017277|Radiation|radiation therapy|
5816847|NCT00017264|Drug|atrasentan hydrochloride|
5816848|NCT00017251|Biological|oblimersen sodium|Given IV
5816849|NCT00017251|Drug|carboplatin|Given IV
5816850|NCT00017251|Drug|etoposide|Given IV
5816851|NCT00017251|Other|pharmacological study|Correlative studies
5816852|NCT00017251|Other|laboratory biomarker analysis|Correlative studies
5816853|NCT00017238|Drug|KRN5500|Given IV
5816854|NCT00017238|Other|pharmacological study|Correlative studies
5816855|NCT00017225|Biological|filgrastim|
5816856|NCT00017225|Drug|carboplatin|
5816857|NCT00017225|Drug|cisplatin|
5816858|NCT00017225|Drug|cyclophosphamide|
5816859|NCT00017225|Drug|dacarbazine|
5816860|NCT00017225|Drug|doxorubicin hydrochloride|
5816861|NCT00017225|Drug|etoposide|
5816862|NCT00017225|Drug|ifosfamide|
5816863|NCT00017225|Drug|melphalan|
5816864|NCT00017225|Drug|tretinoin|
5816865|NCT00017225|Drug|vincristine sulfate|
5816866|NCT00017225|Drug|vindesine|
5816867|NCT00017225|Procedure|autologous bone marrow transplantation|
5816868|NCT00017225|Procedure|conventional surgery|
5816869|NCT00017225|Procedure|peripheral blood stem cell transplantation|
5816870|NCT00017225|Radiation|radiation therapy|
5816871|NCT00017212|Drug|exatecan mesylate|
5816872|NCT00017186|Drug|epirubicin hydrochloride|
5816873|NCT00017186|Drug|gemcitabine hydrochloride|
5816874|NCT00017173|Biological|Ad5CMV-p53 gene|2 intraoperative and one post-operative injection of Ad5CMV-p53.
5816875|NCT00017173|Drug|cisplatin|100 mg/m2 IV Day 1 every 21 days for 3 cycles
5816876|NCT00017173|Procedure|conventional surgery|conventional surgery
5816877|NCT00017173|Radiation|radiation therapy|200 cGy per day Days 105 every week for 6 weeks
5816878|NCT00017160|Drug|doxorubicin|
5816879|NCT00017160|Drug|filgrastim|
5816880|NCT00017160|Drug|ifosfamide|
5816881|NCT00017160|Procedure|biological response modifier therapy|
5816882|NCT00017160|Procedure|brachytherapy|
5816883|NCT00017160|Procedure|chemotherapy|
5816884|NCT00017160|Procedure|colony-stimulating factor therapy|
5816885|NCT00017160|Procedure|conventional surgery|
5816886|NCT00017160|Procedure|cytokine therapy|
5816887|NCT00017160|Procedure|intraoperative radiotherapy|
5816888|NCT00017160|Procedure|radiation therapy|
5816889|NCT00017160|Procedure|surgery|
5816890|NCT00017147|Drug|carmustine|"40 mg/m^2 IV over 1 hour on day 1 of each cycle 6 hours after O6-BG dose for experimental arm with O6=BG.~200 mg/m^2 IV over 1 hour on day 2 of each cycle for the active comparator arm."
5816891|NCT00017147|Radiation|radiation therapy|5 days/week using one fraction per day and a dose of 180 cGy per fraction. Initial target volume is dose of 5040 cGy in 28 fractions with boost target volume of 1080 cGy in 6 fractions.
5816892|NCT00017147|Drug|O6-Benzylguanine|120 mg/m^2 IV over 1 hour on day 1 of each cycle
5816893|NCT00017121|Biological|sargramostim|
5816894|NCT00017108|Drug|chlorambucil|
5816895|NCT00017108|Drug|cyclophosphamide|
5816896|NCT00017108|Drug|fludarabine phosphate|
5816897|NCT00017095|Biological|filgrastim|
5816898|NCT00017095|Drug|cyclophosphamide|
5816899|NCT00017095|Drug|docetaxel|
5816900|NCT00017095|Drug|epirubicin hydrochloride|
5816901|NCT00017095|Drug|fluorouracil|
5816902|NCT00017095|Genetic|microarray analysis|
5816903|NCT00017095|Other|immunohistochemistry staining method|
5816904|NCT00017095|Other|laboratory biomarker analysis|
5816905|NCT00017095|Procedure|biopsy|
5816906|NCT00017095|Procedure|conventional surgery|
5816907|NCT00017095|Procedure|neoadjuvant therapy|
5816908|NCT00017095|Radiation|radiation therapy|
5816909|NCT00017069|Drug|arsenic trioxide|
5816910|NCT00017069|Drug|dexamethasone|
5816911|NCT00017004|Radiation|External Beam Radiation Therapy|Undergo radiation
5816912|NCT00017004|Drug|Cisplatin|Given IV
5816913|NCT00017004|Radiation|Internal Radiation Therapy|Undergo radiation
5816914|NCT00017004|Biological|Epoetin Alfa|Given SC
5816915|NCT00016991|Drug|gefitinib|
5816916|NCT00016965|Drug|ixabepilone|
5816918|NCT00016952|Drug|irinotecan hydrochloride|
5816919|NCT00016952|Drug|leucovorin calcium|
5816920|NCT00016926|Drug|capecitabine|
5816921|NCT00016913|Drug|carboplatin|AUC=6 week one of each 4 week cycle
5816922|NCT00016913|Drug|estramustine|2 tablets tid PO 5 of 7 days per week each 4 week cycle
5816923|NCT00016913|Drug|paclitaxel|80 mg/sq m IV infusion over 1 hour weekly for ea 4 week cycle
5816924|NCT00016913|Radiation|radiation therapy|77.4 Gy in 1.8 Gy fractions
5816925|NCT00016913|Drug|leuprolide or goserelin acetate|7.5 mg IM injection once every 4 weeks for 6 months
5816926|NCT00016887|Biological|filgrastim|
5816927|NCT00016887|Biological|recombinant interferon alfa|
5816928|NCT00016887|Drug|carmustine|
5816929|NCT00016887|Drug|cyclophosphamide|
5816930|NCT00016887|Drug|cytarabine|
5816931|NCT00016887|Drug|dexamethasone|
5816932|NCT00016887|Drug|etoposide|
5816933|NCT00016887|Drug|melphalan|
5816934|NCT00016887|Procedure|bone marrow ablation with stem cell support|
5816935|NCT00016887|Procedure|peripheral blood stem cell transplantation|
5816936|NCT00016887|Radiation|radiation therapy|
5816937|NCT00016861|Drug|irinotecan hydrochloride|
5816938|NCT00016432|Drug|exemestane|25 mg for 5 years
5816939|NCT00016432|Drug|Placebo|Placebo
5816940|NCT00016419|Biological|anti-thymocyte globulin|3.5 mg/kg/d IV over 12 hrs day 1
5816941|NCT00016419|Drug|cyclosporine|3 mg/kg bid days 5-94 then taper to 0 at day 124 PO
5816942|NCT00016406|Biological|filgrastim|
5816943|NCT00016406|Drug|cyclophosphamide|
5816944|NCT00016406|Drug|doxorubicin|
5816945|NCT00016406|Drug|paclitaxel|
5816946|NCT00016406|Procedure|surgery|
5816947|NCT00016393|Drug|ixabepilone|
5816948|NCT00016380|Drug|dexamethasone|
5816949|NCT00016380|Drug|ondansetron|
5816950|NCT00016380|Procedure|quality-of-life assessment|
5816951|NCT00016354|Drug|benzoylphenylurea|
5816952|NCT00016328|Drug|temsirolimus|Given IV
5816953|NCT00016328|Other|laboratory biomarker analysis|Correlative studies
5816954|NCT00016328|Other|pharmacological study|Correlative studies
5816955|NCT00016302|Drug|prednisone|Given orally
5816956|NCT00016302|Drug|vincristine sulfate|Given IV
5816957|NCT00016302|Drug|daunorubicin hydrochloride|Given IV
5816958|NCT00016302|Drug|asparaginase|Given IM
5816959|NCT00016302|Drug|methotrexate|Given IT and orally
5816960|NCT00016302|Drug|cyclophosphamide|Given IV
5816961|NCT00016302|Drug|cytarabine|Given IV or SC
5816962|NCT00016302|Drug|mercaptopurine|Given orally
5816963|NCT00016302|Drug|leucovorin calcium|Given IV or orally
5816964|NCT00016302|Drug|dexamethasone|Given orally
5816965|NCT00016302|Drug|doxorubicin hydrochloride|Given IV
5816966|NCT00016302|Drug|thioguanine|Given orally
5816967|NCT00016302|Radiation|radiation therapy|Undergo cranial irradiation
5816968|NCT00016302|Drug|nelarabine|Given IV
5816969|NCT00016302|Drug|pegaspargase|Given IM
5816970|NCT00016302|Radiation|radiation therapy|Undergo craniocervical radiotherapy
5816971|NCT00016302|Other|pharmacological study|Correlative studies
5816972|NCT00016302|Other|laboratory biomarker analysis|Correlative studies
5816973|NCT00016289|Biological|recombinant interleukin-12|Given intraperitoneally
5816974|NCT00016263|Biological|oblimersen sodium|
5816975|NCT00016263|Drug|dacarbazine|
5816976|NCT00016224|Drug|thalidomide|
5816977|NCT00016211|Radiation|radiation therapy|
5816978|NCT00016185|Drug|alvocidib|
5816979|NCT00016185|Drug|docetaxel|
5816980|NCT00016159|Biological|filgrastim|
5816981|NCT00016159|Biological|lintuzumab|
5816982|NCT00016159|Drug|arsenic trioxide|
5816983|NCT00016159|Drug|idarubicin|
5816984|NCT00016159|Drug|tretinoin|
5816985|NCT00016146|Biological|GPI-0100|
5816986|NCT00016146|Biological|MUC-2-Globo H-KLH conjugate vaccine|
5816987|NCT00016133|Biological|BCG vaccine|
5816988|NCT00016133|Biological|autologous tumor cell vaccine|
5816989|NCT00016133|Drug|fluorouracil|
5816990|NCT00016133|Drug|leucovorin calcium|
5816991|NCT00016133|Procedure|adjuvant therapy|
5816992|NCT00016094|Biological|bevacizumab|Given IV
5816993|NCT00016094|Other|laboratory biomarker analysis|Correlative studies
5816994|NCT00016081|Drug|ribavirin|
5816995|NCT00016068|Drug|ganciclovir|
5816996|NCT00016068|Drug|valganciclovir|
5816997|NCT00016055|Biological|lymphokine-activated killer cells|
5816998|NCT00016055|Drug|temozolomide|
5816999|NCT00016029|Other|screening questionnaire administration|
5817000|NCT00016029|Procedure|barium enema injection|
5817001|NCT00016029|Procedure|computed tomography|
5817002|NCT00016029|Procedure|computed tomography colonography|
5817003|NCT00016029|Procedure|diagnostic colonoscopy|
5817004|NCT00016029|Procedure|screening colonoscopy|
5817005|NCT00016016|Drug|cytarabine|Given IV
5817006|NCT00016016|Drug|mitoxantrone hydrochloride|Given IV
5817007|NCT00016016|Drug|alvocidib|Given IV
5817008|NCT00016016|Other|pharmacological study|Correlative studies
5817009|NCT00016016|Other|laboratory procedure|Correlative studies
5817010|NCT00015977|Biological|PSA prostate cancer vaccine|
5817011|NCT00015977|Biological|recombinant interleukin-12|
5817012|NCT00015951|Biological|bevacizumab|
5817013|NCT00015951|Drug|cytarabine|
5817014|NCT00015951|Drug|mitoxantrone hydrochloride|
5817015|NCT00015938|Biological|filgrastim|
5817016|NCT00015938|Drug|docetaxel|
5817017|NCT00015938|Drug|vinorelbine|
5817018|NCT00015925|Drug|entinostat|
5817019|NCT00015899|Drug|lonafarnib|
5817020|NCT00015873|Drug|asparaginase|
5817025|NCT00015873|Drug|vincristine sulfate|
5817026|NCT00015860|Drug|daunorubicin hydrochloride|
5817027|NCT00015860|Drug|imatinib mesylate|
5817028|NCT00015860|Drug|prednisone|
5817029|NCT00015860|Drug|vincristine sulfate|
5817030|NCT00015847|Biological|recombinant interferon alfa|IFN-α will be given at a dose ranging up to 5 MIU daily via subcutaneous injection.
5817031|NCT00015847|Drug|imatinib mesylate|Once daily oral administration of STI571 (imatinib mesylate) at a dose of 400 mg or 600mg for 12 months.
5817032|NCT00015834|Drug|imatinib mesylate|Given PO
5817033|NCT00015834|Drug|cytarabine|Given IV
5817034|NCT00014612|Procedure|axillary lymph node dissection|
5817035|NCT00014612|Procedure|lymphoscintigraphy|
5817036|NCT00014612|Procedure|therapeutic conventional surgery|
5817037|NCT00014612|Radiation|radiation therapy|
5817038|NCT00014599|Drug|paclitaxel|
5817039|NCT00014586|Drug|bicalutamide|
5817040|NCT00014586|Drug|goserelin acetate|
5817041|NCT00014586|Procedure|orchiectomy|
5817042|NCT00014521|Drug|karenitecin|
5817043|NCT00014508|Biological|sargramostim|
5817044|NCT00014508|Drug|cyclophosphamide|
5817045|NCT00014508|Drug|cyclosporine|
5817046|NCT00014508|Drug|fludarabine phosphate|
5817047|NCT00014508|Drug|melphalan|
5817048|NCT00014508|Procedure|peripheral blood stem cell transplantation|
5817049|NCT00014495|Biological|filgrastim|
5817050|NCT00014495|Drug|cytarabine|
5817051|NCT00014495|Radiation|bismuth Bi213 monoclonal antibody M195|
5817052|NCT00014482|Procedure|pain therapy|
5817053|NCT00014482|Procedure|psychosocial assessment and care|
5817054|NCT00014469|Drug|busulfan|
5817055|NCT00014469|Drug|melphalan|
5817056|NCT00014469|Drug|methotrexate|
5817057|NCT00014469|Drug|tacrolimus|
5817058|NCT00014469|Procedure|allogeneic bone marrow transplantation|
5817059|NCT00014456|Biological|filgrastim|
5817060|NCT00014456|Drug|docetaxel|
5817061|NCT00014456|Drug|gemcitabine hydrochloride|
5817062|NCT00014443|Drug|thalidomide|
5817063|NCT00014443|Drug|topotecan hydrochloride|
5817064|NCT00014378|Drug|Chinese Herb Huanglian (Coptis chinesis)|Patients will receive capsules of the powdered extract of the huanglian root, which will take by mouth 4 times a day (qid).
5817065|NCT00014326|Radiation|radiation therapy|
5817066|NCT00014313|Drug|cisplatin|
5817067|NCT00014313|Drug|etoposide|
5817068|NCT00014274|Drug|carboplatin|
5817069|NCT00014274|Drug|gemcitabine hydrochloride|
5817070|NCT00014274|Drug|methotrexate|
5817071|NCT00014274|Drug|vinblastine sulfate|
5817072|NCT00014235|Drug|fludarabine phosphate|Given IV
5817073|NCT00014235|Radiation|total-body irradiation|Undergo TBI
5817074|NCT00014235|Procedure|peripheral blood stem cell transplantation|Undergo PBSCT
5817075|NCT00014235|Procedure|allogeneic hematopoietic stem cell transplantation|Undergo PBSCT
5817076|NCT00014235|Drug|cyclosporine|Given PO or IV
5817077|NCT00014235|Drug|mycophenolate mofetil|Given IV or PO
5817078|NCT00014235|Other|laboratory biomarker analysis|Correlative studies
5817079|NCT00014222|Biological|epoetin alfa|40,000 IU
5817080|NCT00014222|Biological|filgrastim|5 mg/kg/d - days 2-13
5817081|NCT00014222|Drug|cyclophosphamide|75, 600 and 830 mg/m2
5817082|NCT00014222|Drug|doxorubicin hydrochloride|60 mg/m2
5817083|NCT00014222|Drug|epirubicin hydrochloride|60 mg/m2
5817084|NCT00014222|Drug|fluorouracil|500mg/m2
5817085|NCT00014222|Drug|paclitaxel|175 mg/m2
5817086|NCT00014196|Drug|cisplatin|
5817087|NCT00014196|Drug|docetaxel|
5817088|NCT00014196|Radiation|radiation therapy|
5817089|NCT00014131|Biological|Biological/Vaccine: therapeutic autologous dendritic cells.|Biological/Vaccine: therapeutic autologous dendritic cells. Apheresis procedure collects peripheral blood mononuclear cells (PBMC) for the production of dendritic cell, which are admixed with irradiated tumor cells from autologous tumor cell line for vaccine product.
5817090|NCT00014118|Drug|carboplatin|
5817091|NCT00014118|Drug|paclitaxel|
5817092|NCT00014118|Procedure|conventional surgery|
5817093|NCT00014118|Radiation|radiation therapy|
5817094|NCT00014092|Biological|aldesleukin|
5817095|NCT00014092|Biological|recombinant interferon alfa|
5817096|NCT00014092|Biological|sargramostim|
5817097|NCT00014092|Drug|temozolomide|
5817098|NCT00014079|Genetic|DNA stability analysis|
5817099|NCT00014079|Genetic|loss of heterozygosity analysis|
5817100|NCT00014079|Genetic|microsatellite instability analysis|
5817101|NCT00012389|Drug|irinotecan hydrochloride|
5817102|NCT00012389|Drug|oxaliplatin|
5817103|NCT00012376|Drug|bryostatin 1|Given IV
5817104|NCT00012376|Biological|sargramostim|Given subcutaneously
5817105|NCT00012376|Other|laboratory biomarker analysis|Correlative studies
5817106|NCT00012376|Other|pharmacological study|Correlative studies
5817107|NCT00012363|Drug|gemcitabine hydrochloride|1,000mg/m2, IV over 30 min, days 1 & 8, q 21 days
5817108|NCT00012363|Drug|irinotecan hydrochloride|100 mg/m2, IV over 90 min, days 1 & 8, q 21days
5817109|NCT00012324|Drug|doxorubicin hydrochloride|
5817110|NCT00012324|Drug|nolatrexed dihydrochloride|
5817111|NCT00012298|Biological|rituximab|Given IV
5817112|NCT00012298|Biological|yttrium Y 90 ibritumomab tiuxetan|Given IV
5817113|NCT00012298|Biological|indium In 111 ibritumomab tiuxetan|Given IV
5817114|NCT00012298|Biological|oprelvekin|Given subcutaneously
5817115|NCT00012298|Biological|filgrastim|Given subcutaneously
5817116|NCT00012246|Biological|carcinoembryonic antigen peptide 1-6D|
5817117|NCT00012246|Biological|incomplete Freund's adjuvant|
5817118|NCT00012246|Biological|sargramostim|
5817200|NCT00010192|Biological|aldesleukin|Given SC
5817119|NCT00012220|Drug|cisplatin|50 mg/sq m IV infusion over 30 min on Days 1 & 15 of ea cycle
5817120|NCT00012220|Drug|docetaxel|40 mg/sq m IV infusion over 60 min on Days 1 & 8 of ea treatment cycle
5817121|NCT00012220|Drug|gemcitabine hydrochloride|"Gemcitabine only arm: 1500 mg/sq m in 250 mL NS IV infusion over 150 min Days 1, 8, & 15 of ea cycle~cisplastin arm: 1000 mg/sq m 250 mL NS IV infusion over 30 min Days 1, 8, 15 of ea cycle~docetaxel and + irinotecan arms: 1000 mg/sq m in 250 mL NS IV infusion over 30 min Days 1 & 8 of ea cycle"
5817122|NCT00012220|Drug|irinotecan hydrochloride|100 mg/q m in 500 mL D5W or D5NS IV infusion over 90 min Days 1 & 8 of ea cycle
5817123|NCT00012207|Biological|aldesleukin|
5817124|NCT00012207|Biological|therapeutic autologous lymphocytes|
5817125|NCT00012207|Drug|cyclophosphamide|
5817126|NCT00012207|Drug|prednisone|
5817127|NCT00012207|Drug|vincristine sulfate|
5817128|NCT00012207|Procedure|adjuvant therapy|
5817129|NCT00012194|Drug|7-hydroxystaurosporine|Given IV
5817130|NCT00012194|Drug|cisplatin|Given IV
5817131|NCT00012194|Other|laboratory biomarker analysis|Correlative studies
5817132|NCT00012181|Drug|alvocidib|Given IV
5817133|NCT00012181|Other|pharmacological study|Correlative studies
5817134|NCT00012168|Drug|isosulfan blue|
5817135|NCT00012168|Genetic|polymerase chain reaction|
5817136|NCT00012168|Other|immunohistochemistry staining method|
5817137|NCT00012168|Procedure|lymphangiography|
5817138|NCT00012168|Procedure|radionuclide imaging|
5817139|NCT00012168|Procedure|sentinel lymph node biopsy|
5817140|NCT00012168|Radiation|technetium Tc 99m sulfur colloid|
5817141|NCT00012103|Other|bronchoalveolar lavage|
5817142|NCT00012103|Other|screening questionnaire administration|
5817143|NCT00012103|Other|sputum cytology|
5817144|NCT00012103|Procedure|bronchoscopic and lung imaging studies|
5817145|NCT00012103|Procedure|bronchoscopy|
5817146|NCT00012103|Procedure|computed tomography|
5817147|NCT00012103|Procedure|study of high risk factors|
5817148|NCT00012064|Biological|therapeutic autologous dendritic cells|Apheresis procedure collects peripheral blood mononuclear cells (PBMC) for the production of dendritic cell, which are admixed with irradiated tumor cells from autologous tumor cell line for vaccine product.
5817149|NCT00012051|Biological|filgrastim|
5817150|NCT00012051|Biological|rituximab|
5817151|NCT00012051|Drug|carmustine|
5817152|NCT00012051|Drug|cisplatin|
5817153|NCT00012051|Drug|cytarabine|
5817154|NCT00012051|Drug|dexamethasone|
5817155|NCT00012051|Drug|etoposide|
5817156|NCT00012051|Drug|ifosfamide|
5817157|NCT00012051|Drug|melphalan|
5817158|NCT00012051|Drug|methotrexate|
5817159|NCT00012051|Procedure|bone marrow ablation with stem cell support|
5817160|NCT00012051|Procedure|peripheral blood stem cell transplantation|
5817161|NCT00012051|Radiation|radiation therapy|
5817162|NCT00012038|Drug|irofulven|
5817163|NCT00012025|Drug|fulvestrant|
5817164|NCT00012012|Drug|Amifostine trihydrate|Amifostine will be delivered before each radiation treatment. Amifostine (500 mg) will be given as two equally-divided subcutaneous injections.
5817165|NCT00012012|Drug|Cisplatin|Cisplatin will be given weekly with external beam radiation therapy and once with brachytherapy for a total of six doses. Patients receive 40 mg/m^2 by IV over 30-60 minutes on days 1, 8, 15, 22, 29, and 36.
5817166|NCT00012012|Radiation|Intracavitary brachytherapy|For low dose rate (LDR) brachytherapy, cesium will be given in one to two intracavitary applications, within two weeks of completion of external radiation. The interval between the two applications will be one to three weeks. It is recommended that the total course of treatment be completed in less than eight weeks. High dose rate (HDR) brachytherapy may start as early as week two of external radiation. The minimum cumulative external and intracavitary dose should be 85 Gy.
5817167|NCT00012012|Radiation|External beam radiation therapy|Patients will receive 1.8 Gy daily for five weeks for a total dose of 45 Gy; involved lateral parametrium and/or pelvic nodes should be boosted for a total dose (including intracavitary treatment) of 60 Gy ± 5%.
5817168|NCT00011999|Drug|cisplatin|
5817169|NCT00011999|Drug|paclitaxel|
5817170|NCT00011999|Procedure|conventional surgery|
5817171|NCT00011999|Radiation|radiation therapy|
5817172|NCT00011986|Drug|Paclitaxel|Given IV
5817173|NCT00011986|Drug|Carboplatin|Given IV
5817174|NCT00011986|Drug|Gemcitabine Hydrochloride|Given IV
5817175|NCT00011986|Drug|Pegylated Liposomal Doxorubicin Hydrochloride|
5817176|NCT00011986|Drug|Topotecan Hydrochloride|Given IV
5817177|NCT00011986|Procedure|Therapeutic Conventional Surgery|Undergo surgery
5817178|NCT00011960|Drug|cisplatin|
5817179|NCT00011960|Drug|paclitaxel|
5817180|NCT00011960|Procedure|adjuvant therapy|
5817181|NCT00011960|Radiation|radiation therapy|
5817182|NCT00011921|Biological|filgrastim|
5817183|NCT00011921|Drug|carboplatin|
5817184|NCT00011921|Drug|epirubicin hydrochloride|
5817185|NCT00011921|Drug|etoposide|
5817186|NCT00011921|Drug|etoposide phosphate|
5817187|NCT00011921|Drug|ifosfamide|
5817188|NCT00011921|Drug|paclitaxel|
5817189|NCT00011921|Procedure|autologous bone marrow transplantation|
5817190|NCT00011921|Procedure|bone marrow ablation with stem cell support|
5817191|NCT00011921|Procedure|peripheral blood stem cell transplantation|
5817192|NCT00011921|Radiation|radiation therapy|
5817193|NCT00010270|Biological|LMB-9 immunotoxin|
5817194|NCT00010257|Drug|carboplatin|Dosed to AUC of 6.0, given IV over 30 minutes day 1 of a 21-day cycle, for up to 6 cycles
5817195|NCT00010257|Drug|paclitaxel|225 mg/m2 given by intravenous (IV) infusion over 3 hours on day 1 of a 21-day cycle, for up to 6 cycles
5817196|NCT00010218|Drug|karenitecin|
5817197|NCT00010205|Drug|benzoylphenylurea|Given orally
5817198|NCT00010205|Other|pharmacological study|Correlative studies
5817199|NCT00010192|Biological|rituximab|Given IV
5817201|NCT00010192|Other|laboratory biomarker analysis|Correlative studies
5817202|NCT00010192|Other|pharmacological study|Correlative studies
5817203|NCT00010166|Drug|gemcitabine hydrochloride|
5817204|NCT00010166|Procedure|adjuvant therapy|
5817205|NCT00010166|Radiation|radiation therapy|
5817206|NCT00010153|Drug|fulvestrant|
5817207|NCT00010153|Procedure|conventional surgery|
5817208|NCT00010140|Drug|docetaxel|
5817209|NCT00010140|Drug|epirubicin hydrochloride|
5817210|NCT00010140|Drug|tamoxifen citrate|
5817211|NCT00010140|Procedure|adjuvant therapy|
5817212|NCT00010075|Drug|fluorouracil|
5817213|NCT00010075|Drug|leucovorin calcium|
5817214|NCT00010075|Drug|mitoxantrone hydrochloride|
5817215|NCT00010062|Drug|fluorouracil|
5817216|NCT00010062|Radiation|radiation therapy|
5817217|NCT00010049|Drug|imatinib mesylate|
5817218|NCT00010023|Drug|capecitabine|
5817219|NCT00010023|Drug|cisplatin|
5817220|NCT00009984|Drug|fludarabine phosphate|Given IV
5817221|NCT00009984|Drug|thalidomide|Given orally
5817222|NCT00009971|Drug|fenretinide|
5817223|NCT00009945|Drug|clodronate|1600 mg PO daily
5817224|NCT00009945|Drug|placebo|2 pills PO daily
5817225|NCT00009880|Biological|filgrastim|
5817226|NCT00009880|Drug|cisplatin|
5817227|NCT00009880|Drug|fluorouracil|
5817228|NCT00009880|Drug|paclitaxel|
5817229|NCT00009880|Radiation|radiation therapy|
5817230|NCT00009854|Drug|carmustine in ethanol|
5817231|NCT00009854|Procedure|conventional surgery|
5817232|NCT00009776|Biological|monoclonal antibody Lym-1|
5817233|NCT00009776|Drug|cyclosporine|
5817234|NCT00009776|Drug|paclitaxel|
5817235|NCT00009776|Radiation|indium In 111 monoclonal antibody Lym-1|
5817236|NCT00009776|Radiation|yttrium Y 90 monoclonal antibody Lym-1|
5817237|NCT00009763|Biological|filgrastim|
5817238|NCT00009763|Biological|monoclonal antibody m170|
5817239|NCT00009763|Drug|cyclosporine|
5817240|NCT00009763|Drug|paclitaxel|
5817241|NCT00009763|Procedure|peripheral blood stem cell transplantation|
5817242|NCT00009763|Radiation|yttrium Y 90 monoclonal antibody m170|
5817243|NCT00009750|Biological|filgrastim|
5817244|NCT00009750|Biological|monoclonal antibody m170|
5817245|NCT00009750|Drug|cyclosporine|
5817246|NCT00009750|Drug|paclitaxel|
5817247|NCT00009750|Procedure|peripheral blood stem cell transplantation|
5817248|NCT00009750|Radiation|indium In 111 monoclonal antibody m170|
5817249|NCT00009750|Radiation|yttrium Y 90 monoclonal antibody m170|
5817250|NCT00009711|Procedure|management of therapy complications|
5817251|NCT00008697|Drug|arsenic trioxide|
5817252|NCT00008437|Device|high-intensity focused ultrasound ablation|
5817253|NCT00008411|Drug|Docetaxel|Every 3 weeks at a starting dose of 75 mg/m2 IV over 1 hour on day 1, repeated every 21 days.
5817254|NCT00008411|Drug|Docetaxel|35 mg/m2 IV over 30 minutes on days 1, 8, and 15, for 3 weeks followed by one week of rest repeated every 28 days.
5817255|NCT00008385|Other|placebo|Given orally
5817256|NCT00008385|Drug|selenium|Given orally
5817257|NCT00008346|Diagnostic Test|Full Field Digital Mammography|Radiologic test to screen women for Breast cancer using digital detectors
5817258|NCT00008346|Diagnostic Test|Screen Film Mammography|Radiologic test to screen women for Breast cancer using plain film detectors a resolution screen
5817259|NCT00008307|Biological|anti-thymocyte globulin|
5817260|NCT00008307|Drug|cyclosporine|
5817261|NCT00008307|Drug|fludarabine phosphate|
5817262|NCT00008307|Drug|melphalan|
5817263|NCT00008307|Drug|methylprednisolone|
5817264|NCT00008307|Drug|mycophenolate mofetil|
5817265|NCT00008307|Procedure|allogeneic bone marrow transplantation|
5817266|NCT00008307|Procedure|peripheral blood stem cell transplantation|
5817267|NCT00008307|Procedure|syngeneic bone marrow transplantation|
5817268|NCT00008294|Drug|FOLFOX regimen|
5817269|NCT00008294|Drug|dexamethasone|
5817270|NCT00008294|Drug|floxuridine|
5817271|NCT00008294|Drug|fluorouracil|
5817272|NCT00008294|Drug|leucovorin calcium|
5817273|NCT00008294|Drug|oxaliplatin|
5817274|NCT00008268|Biological|filgrastim|
5817275|NCT00008268|Drug|melphalan|
5817276|NCT00008216|Procedure|Peripheral Blood Stem Cell Transplantation|
5817277|NCT00008190|Biological|aldesleukin|
5817278|NCT00008190|Biological|filgrastim|
5817279|NCT00008190|Drug|busulfan|
5817280|NCT00008190|Drug|cyclophosphamide|
5817281|NCT00008190|Drug|etoposide|
5817282|NCT00008190|Drug|melphalan|
5817283|NCT00008190|Procedure|peripheral blood stem cell transplantation|
5817284|NCT00008164|Procedure|umbilical cord blood transplantation|
5817285|NCT00008138|Drug|carboplatin|pre-surgery - target AUC=6, Day 1 IV, q 21 days X 3 cycles post-surgery - target AUC=5, Day 1 IP, q 28 days X 6 cycles
5817286|NCT00008138|Drug|paclitaxel|pre-surgery - 175 mg/m2 IV Day 1, q 21 days X 3 cycles post-surgery - 175 mg/m2 IV Day 1, q 28 days X 6 cycles AND 60 mg/m2 IP Day 8, q 28 days X 6 cycles
5817287|NCT00008138|Procedure|debulking surgery|exploratory laparotomy, interval cytoreduction (to < 1 cm residual)
5817288|NCT00008060|Drug|FOLFIRI regimen|
5817289|NCT00008060|Drug|FOLFOX regimen|
5817290|NCT00008060|Drug|fluorouracil|
5817291|NCT00008060|Drug|irinotecan hydrochloride|
5817292|NCT00008060|Drug|leucovorin calcium|
5817293|NCT00008060|Drug|oxaliplatin|
5817294|NCT00008047|Drug|fluorouracil|
5817295|NCT00008047|Drug|hydroxyurea|
5817296|NCT00008047|Drug|paclitaxel|
5817297|NCT00008047|Procedure|conventional surgery|
5817298|NCT00008047|Radiation|radiation therapy|
5817299|NCT00008008|Biological|filgrastim|
5817303|NCT00008008|Procedure|autologous bone marrow transplantation|
5817304|NCT00008008|Procedure|bone marrow ablation with stem cell support|
5817305|NCT00008008|Procedure|peripheral blood stem cell transplantation|
5817306|NCT00007995|Biological|filgrastim|
5817307|NCT00007995|Biological|recombinant interferon alfa|
5817308|NCT00007995|Biological|sargramostim|
5817309|NCT00007995|Drug|busulfan|
5817310|NCT00007995|Drug|cyclophosphamide|
5817311|NCT00007995|Drug|melphalan|
5817312|NCT00007995|Procedure|autologous bone marrow transplantation|
5817313|NCT00007995|Procedure|bone marrow ablation with stem cell support|
5817314|NCT00007995|Procedure|peripheral blood stem cell transplantation|
5817315|NCT00007982|Biological|filgrastim|
5817316|NCT00007982|Drug|carmustine|
5817317|NCT00007982|Drug|cisplatin|
5817318|NCT00007982|Drug|cyclophosphamide|
5817319|NCT00007982|Drug|etoposide|
5817320|NCT00007982|Drug|thiotepa|
5817321|NCT00007982|Procedure|adjuvant therapy|
5817322|NCT00007982|Procedure|autologous bone marrow transplantation|
5817323|NCT00007982|Procedure|bone marrow ablation with stem cell support|
5817324|NCT00007982|Procedure|peripheral blood stem cell transplantation|
5817325|NCT00007956|Biological|monoclonal antibody mono-dgA-RFB4|
5817326|NCT00007930|Procedure|conventional surgery|
5817327|NCT00007930|Procedure|laparoscopic surgery|
5817328|NCT00007904|Biological|filgrastim|Neupogen (G-CSF) given at a dose of 10 ugm/kg subcutaneously starting on day 5 and continuing until ANC > 10,000/uL x1 day after the nadir cycles 1-3.
5817329|NCT00007904|Drug|cyclophosphamide|cyclophosphamide 700 mg/m2 daily for 3 day every 3 weeks cycles 1-3
5817330|NCT00007904|Drug|doxorubicin hydrochloride|Patients then receive doxorubicin IV on day 1.
5817331|NCT00007904|Drug|paclitaxel|Paclitaxel 160 mg/m2 given over 72 hours by continuous infusion days 1-3
5817332|NCT00007904|Drug|tamoxifen citrate|tamoxifen at a dose of 20 mg daily for 5 years after chemotherapy is completed
5817333|NCT00007904|Procedure|adjuvant therapy|Patients receive paclitaxel IV continuously and cyclophosphamide IV over 2 hours on days 1-3. Patients also receive filgrastim (G-CSF) subcutaneously (SC) beginning on day 5 and continuing until day 14 or until blood counts recover. Treatment repeats every 21 days for 3 courses. Patients then receive doxorubicin IV on day 1 and G-CSF SC on days 2-11 every 21 days for 4 courses.
5817334|NCT00007904|Radiation|radiation therapy|Beginning 3-6 weeks after the completion of chemotherapy, patients receive radiotherapy 5 days a week for 6-7 weeks.
5817335|NCT00007891|Biological|filgrastim|
5817336|NCT00007891|Procedure|autologous bone marrow transplantation|
5817337|NCT00007891|Procedure|peripheral blood stem cell transplantation|
5817338|NCT00007891|Radiation|indium In 111 monoclonal antibody BrE-3|
5817339|NCT00007891|Radiation|yttrium Y 90 monoclonal antibody BrE-3|
5817340|NCT00007865|Biological|rituximab|
5817341|NCT00007865|Drug|carboplatin|
5817342|NCT00007865|Drug|etoposide|
5817343|NCT00007865|Drug|ifosfamide|
5817344|NCT00007826|Biological|BCG vaccine|
5817345|NCT00007826|Biological|monoclonal antibody 105AD7 anti-idiotype vaccine|
5817346|NCT00007826|Drug|alum adjuvant|
5817347|NCT00006994|Dietary Supplement|glutamine|20 cc three times daily for 60 days
5817348|NCT00006994|Radiation|radiation therapy|Per institutional standard; minimum of 6,000 cGy with a daily dose of 180-200 cGy.
5817349|NCT00006994|Drug|l-glutamine placebo|20 cc three times daily for 60 days
5817350|NCT00006981|Biological|SS1(dsFv)-PE38 immunotoxin|
5817351|NCT00006942|Drug|bryostatin 1|Given IV
5817352|NCT00006942|Drug|cisplatin|Given IV
5817353|NCT00006942|Other|laboratory biomarker analysis|Correlative studies
5817354|NCT00006929|Drug|suramin|Given IV
5817355|NCT00006929|Drug|carboplatin|Given IV
5817356|NCT00006929|Drug|paclitaxel|Given IV
5817357|NCT00006929|Other|pharmacological study|Correlative studies
5817358|NCT00006929|Other|laboratory biomarker analysis|Correlative studies
5817359|NCT00006916|Biological|bleomycin|
5817360|NCT00006916|Device|Ommaya reservoir|
5817361|NCT00006916|Radiation|radiation therapy|60.0 Gy/30 fractions x 2.0 Gy. For the first 46 Gy/23 fractions the treatment volume should include the volume of contrast-enhancing lesion and surrounding edema on pre-operative CT/MRI scan plus a 2 centimeter margin. If no edema is present, the margin should be 2.5 cm. After 46.0 Gy, the tumor volume should include the contrast-enhancing lesion (without edema) on the pre-surgery MRI/CT scan plus a 2.5 centimeter margin.
5817362|NCT00006903|Drug|Fulvestrant|Given intramuscularly
5817363|NCT00006825|Biological|trastuzumab|
5817364|NCT00006825|Drug|pegylated liposomal doxorubicin hydrochloride|
5817365|NCT00006773|Drug|bortezomib|Given IV
5817366|NCT00006760|Biological|filgrastim|subcutaneously or IV over 15-30 minutes beginning 24-36 hours after completion of vinorelbine and continuing daily until blood counts recover.
5817367|NCT00006760|Drug|ifosfamide|V over 24 hours on days 1-4
5817368|NCT00006760|Drug|vinorelbine tartrate|IV over 6-10 minutes on days 1 and 5.
5817369|NCT00006747|Drug|carmustine|IV
5817370|NCT00006747|Drug|melphalan|IV
5817371|NCT00006747|Drug|etoposide|IV
5817372|NCT00006747|Drug|cytarabine|IV
5817373|NCT00006747|Drug|tacrolimus|IV
5817374|NCT00006747|Drug|methotrexate|IV
5817375|NCT00006747|Drug|sargramostim|IV
5817376|NCT00006747|Procedure|transplant|
5817377|NCT00006734|Biological|filgrastim|Given IV
5817378|NCT00006734|Drug|cyclophosphamide|Given IV
5817379|NCT00006734|Drug|doxorubicin hydrochloride|Given IV
5817380|NCT00006734|Drug|etoposide|Given IV
5817381|NCT00006734|Drug|ifosfamide|Given IV
5817382|NCT00006734|Drug|vincristine sulfate|Given IV
5817383|NCT00006734|Procedure|adjuvant therapy|
5817384|NCT00006734|Procedure|conventional surgery|
5817385|NCT00006734|Procedure|neoadjuvant therapy|
5817387|NCT00006734|Radiation|radiation therapy|
5817388|NCT00006721|Biological|rituximab|Given IV
5817389|NCT00006721|Drug|cyclophosphamide|Given IV
5817390|NCT00006721|Drug|doxorubicin|Given IV
5817391|NCT00006721|Drug|prednisone|Given orally
5817392|NCT00006721|Drug|vincristine|Given IV
5817393|NCT00006721|Radiation|tositumomab|Given IV
5817394|NCT00006695|Drug|carmustine|300 mg/m2 IV on Day -6
5817395|NCT00006695|Drug|cytarabine|100 mg/m2 BID on Days -5 through -2
5817396|NCT00006695|Drug|etoposide|100 mg/m2 BID on Days -5 through -2
5817397|NCT00006695|Drug|melphalan|140 mg/m2 IV on Day -1
5817398|NCT00006695|Procedure|peripheral blood stem cell transplantation|Following the chemotherapy, on Day 0 of treatment, the previously stored hematopoietic stem cells will be administered to the patient intravenously through a central line to the patient.
5817399|NCT00006695|Radiation|tositumomab and iodine I 131 tositumomab|"Patients will receive two administrations of Iodine-131 Anti-B1 Antibody; the dosimetric dose and the therapeutic dose. The dosimetric dose will consist of an infusion of unlabeled Anti-B1 Antibody (450 mg) immediately followed by an infusion of Anti-B1 Antibody (35 mg) which has been trace labeled with 5 mCi of Iodine-131 Anti-B1 Antibody. Using whole body anterior and posterior gamma camera scans and serial imaging studies over approximately one week, the clearance of the whole body dosimetric dose will be used to calculate the subsequent therapeutic dose of Iodine-131 Anti-B1 Antibody which delivers a total body dose of 75 cGy to the subject"
5817400|NCT00006656|Drug|carmustine in ethanol|
5817401|NCT00006656|Procedure|conventional surgery|
5817402|NCT00006485|Drug|alvocidib|
5817403|NCT00006485|Drug|irinotecan hydrochloride|
5817404|NCT00006479|Drug|FOLFOX regimen|
5817405|NCT00006479|Drug|fluorouracil|
5817406|NCT00006479|Drug|leucovorin calcium|
5817407|NCT00006479|Drug|oxaliplatin|
5817408|NCT00006479|Procedure|adjuvant therapy|
5817409|NCT00006479|Procedure|conventional surgery|
5817410|NCT00006479|Procedure|neoadjuvant therapy|
5817411|NCT00006478|Biological|autologous tumor cell vaccine|
5817412|NCT00006478|Biological|keyhole limpet hemocyanin|
5817413|NCT00006478|Biological|sargramostim|
5817414|NCT00006478|Procedure|adjuvant therapy|
5817415|NCT00006477|Dietary Supplement|mistletoe extract|
5817416|NCT00006476|Drug|suramin|
5817417|NCT00006476|Procedure|conventional surgery|
5817418|NCT00006474|Drug|O6-benzylguanine|
5817419|NCT00006474|Drug|temozolomide|
5817420|NCT00006474|Procedure|conventional surgery|
5817421|NCT00006473|Drug|oxaliplatin|Given IV
5817422|NCT00006471|Drug|Fenretinide|1800 mg/m2 per day for seven consecutive days, in two divided doses of 900 mg/m2 12 hours apart, repeated every 3 weeks.
5817423|NCT00006470|Biological|monoclonal antibody 11D10 anti-idiotype vaccine|
5817424|NCT00006470|Biological|monoclonal antibody 3H1 anti-idiotype vaccine|
5817425|NCT00006470|Radiation|radiation therapy|
5817426|NCT00006469|Drug|carboplatin|
5817427|NCT00006469|Drug|paclitaxel|
5817428|NCT00006469|Procedure|conventional surgery|
5817429|NCT00006469|Procedure|neoadjuvant therapy|
5817430|NCT00006469|Radiation|radiation therapy|
5817431|NCT00006468|Drug|FOLFOX regimen|
5817432|NCT00006468|Drug|fluorouracil|
5817433|NCT00006468|Drug|leucovorin calcium|
5817434|NCT00006468|Drug|oxaliplatin|
5817435|NCT00006465|Drug|capecitabine|Patients receive oral capecitabine twice daily on days 1-5 weekly for 4 weeks. Treatment repeats every 6 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of irinotecan and capecitabine until the maximum tolerated dose(MTD).
5817436|NCT00006465|Drug|irinotecan hydrochloride|Patients receive irinotecan IV over 30 minutes once weekly for 4 weeks (one hour after oxaliplatin). Treatment repeats every 6 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of irinotecan and capecitabine until the maximum tolerated dose(MTD).
5817437|NCT00006465|Drug|oxaliplatin|Patients receive oxaliplatin IV over 2 hours. Treatment repeats every 6 weeks in the absence of disease progression or unacceptable toxicity.
5817438|NCT00006462|Drug|gemcitabine hydrochloride|
5817439|NCT00006461|Drug|cisplatin|Given IV
5817440|NCT00006461|Drug|cyclophosphamide|Given IV
5817441|NCT00006461|Drug|vincristine sulfate|Given IV
5817442|NCT00006461|Drug|etoposide|Given PO
5817443|NCT00006461|Procedure|therapeutic conventional surgery|Undergo surgery
5817444|NCT00006461|Radiation|3-dimensional conformal radiation therapy|Undergo 3-dimensional conformal radiation therapy
5817445|NCT00006456|Radiation|stereotactic radiosurgery|
5817446|NCT00006455|Drug|cyclophosphamide|
5817447|NCT00006455|Drug|cytarabine|
5817448|NCT00006455|Drug|dexamethasone|
5817449|NCT00006455|Drug|doxorubicin hydrochloride|
5817450|NCT00006455|Drug|etoposide|
5817451|NCT00006455|Drug|ifosfamide|
5817452|NCT00006455|Drug|leucovorin calcium|
5817453|NCT00006455|Drug|methotrexate|
5817454|NCT00006455|Drug|therapeutic hydrocortisone|
5817455|NCT00006455|Drug|vinblastine sulfate|
5817456|NCT00006392|Drug|Vitamin E|400 IU daily by mouth for 7-12 years
5817457|NCT00006392|Drug|Selenium|200 mcg daily for 7-12 years
5817458|NCT00006392|Other|Vitamin E placebo|daily for 7-12 years
5817459|NCT00006392|Other|selenium placebo|daily for 7-12 years
5817460|NCT00006391|Drug|oxaliplatin|
5817461|NCT00006391|Drug|topotecan hydrochloride|
5817462|NCT00006390|Biological|alemtuzumab|
5817463|NCT00006390|Biological|filgrastim|
5817464|NCT00006390|Drug|cyclophosphamide|
5817465|NCT00006390|Procedure|peripheral blood stem cell transplantation|
5817466|NCT00006390|Radiation|radiation therapy|
5817467|NCT00006389|Drug|bryostatin 1|Given IV
5817468|NCT00006389|Drug|cisplatin|Given IV
5822961|NCT00002069|Drug|Ditiocarb sodium|
5817469|NCT00006389|Other|laboratory biomarker analysis|Correlative studies
5817470|NCT00006386|Drug|carmustine|
5817471|NCT00006386|Radiation|radiation therapy|
5817472|NCT00006386|Radiation|stereotactic radiosurgery|
5817473|NCT00006385|Biological|MART-1 antigen|
5817474|NCT00006385|Biological|gp100 antigen|
5817475|NCT00006385|Biological|incomplete Freund's adjuvant|
5817476|NCT00006385|Biological|recombinant interferon alfa|
5817477|NCT00006385|Biological|sargramostim|
5817478|NCT00006385|Biological|tyrosinase peptide|
5817479|NCT00006381|Biological|trastuzumab|
5817480|NCT00006381|Drug|celecoxib|
5817481|NCT00006379|Biological|anti-thymocyte globulin|anti-thymocyte globulin IV over at least 4 hours on days -2 and -1
5817482|NCT00006379|Biological|graft-versus-tumor induction therapy|Patients undergo filgrastim (G-CSF)-mobilized allogeneic peripheral blood stem cell transplantation on day 0.
5817483|NCT00006379|Drug|cyclophosphamide|cyclophosphamide IV over 2 hours on days -3 to -2
5817484|NCT00006379|Drug|fludarabine phosphate|fludarabine IV over 30 minutes on days -8 to -4
5817485|NCT00006379|Procedure|peripheral blood stem cell transplantation|Patients undergo filgrastim (G-CSF)-mobilized allogeneic peripheral blood stem cell transplantation on day 0.
5817486|NCT00006373|Drug|etoposide|Etoposide IV 500 mg/m2/day over 24 hours Days -5, -4, -3
5817487|NCT00006373|Drug|ifosfamide|Ifosfamide 3,333 mg/m2/day IV over 2 hours (total dose 10,000 mg/m2)Days -8, -7, -6
5817488|NCT00006373|Drug|topotecan hydrochloride|Topotecan 21.3 mg/m2/day (total dose 64 mg/m2 ) IV over 30 minutes Days -8, -7, -6
5817489|NCT00006373|Procedure|autologous bone marrow transplantation|
5817490|NCT00006373|Drug|Mesna|Mesna 1,111 mg/m2/dose IV over 30 minutes; 30 minutes before and 4 and 8 hours after ifosfamide (total dose 10,000 mg/m2) Days -8, -7, -6
5817491|NCT00006372|Drug|gemcitabine hydrochloride|Patients receive gemcitabine IV over 30 minutes on days 1 and 8. Treatment continues every 28 days in the absence of disease progression or unacceptable toxicity.
5817492|NCT00006372|Drug|pegylated liposomal doxorubicin hydrochloride|Patients receive doxorubicin HCl liposome IV over 1-2.5 hours on day 1. Treatment continues every 28 days in the absence of disease progression or unacceptable toxicity.
5817493|NCT00006372|Drug|vinorelbine ditartrate|Patients receive vinorelbine IV over 6-10 minutes on days 1 and 15. Treatment continues every 28 days in the absence of disease progression or unacceptable toxicity.
5817494|NCT00006366|Drug|fluorouracil|
5817495|NCT00006366|Drug|irinotecan hydrochloride|
5817496|NCT00006366|Procedure|conventional surgery|
5817497|NCT00006366|Radiation|radiation therapy|
5817498|NCT00006364|Drug|omacetaxine mepesuccinate|Given IV or SC
5817499|NCT00006364|Other|pharmacological study|Correlative studies
5817500|NCT00006364|Other|laboratory biomarker analysis|Correlative studies
5817501|NCT00006363|Drug|cytarabine|Given IV
5817502|NCT00006363|Drug|daunorubicin hydrochloride|Given IV
5817503|NCT00006363|Drug|etoposide|Given IV
5817504|NCT00006363|Drug|valspodar|Given IV
5817505|NCT00006363|Biological|filgrastim|Given SC
5817506|NCT00006363|Drug|busulfan|Given orally
5817507|NCT00006363|Procedure|autologous hematopoietic stem cell transplantation|Undergo autologous PBSCT
5817508|NCT00006363|Procedure|peripheral blood stem cell transplantation|Undergo autologous PBSCT
5817509|NCT00006363|Biological|aldesleukin|Given SC
5817510|NCT00006363|Other|clinical observation|Undergo clinical observation
5817511|NCT00006363|Other|pharmacological study|Correlative studies
5817512|NCT00006362|Drug|bortezomib|
5817513|NCT00006360|Drug|radioprotection|
5817514|NCT00006360|Radiation|radiation therapy|
5817515|NCT00006359|Drug|LHRH agonist|Lupron: 22.5mg IM injection q 12 wks x 2 OR Zoladex: 10.8 mg subQ injection q 12 wks x 2
5817516|NCT00006359|Drug|antiandrogen|flutamide 250 mg PO tid for 4 wks OR casodex 50 mg PO daily for 4 wks
5817517|NCT00006359|Radiation|radiation therapy|4500 cGy total dose given days 1-5 for 5 weeks following initiation of androgen suppression (25 fractions)
5817518|NCT00006359|Radiation|Brachytherapy boost|Iodine 125 0.3 to 0.5 U per seed OR palladium 103 1.04 to 1.4 U per seed as implant; prescribed dose of I-125 100 Gy (TG-43) and Pd-103 90 Gy
5817519|NCT00006356|Drug|carboplatin|
5817520|NCT00006356|Drug|cisplatin|
5817521|NCT00006356|Procedure|conventional surgery|
5817522|NCT00006355|Drug|pyrazoloacridine|
5817523|NCT00006355|Procedure|adjuvant therapy|
5817524|NCT00006355|Radiation|radiation therapy|
5817525|NCT00006354|Dietary Supplement|mistletoe extract|
5817526|NCT00006351|Drug|gemcitabine hydrochloride|
5817527|NCT00006351|Drug|lonafarnib|
5817528|NCT00006347|Radiation|indium In 111 monoclonal antibody MN-14|
5817529|NCT00006347|Radiation|yttrium Y 90 monoclonal antibody MN-14|
5817530|NCT00006340|Drug|arginine butyrate|
5817531|NCT00006340|Drug|ganciclovir|
5817532|NCT00006268|Biological|cintredekin besudotox|
5817533|NCT00006268|Drug|isolated perfusion|
5817534|NCT00006268|Procedure|conventional surgery|
5817535|NCT00006267|Drug|rubitecan|
5817536|NCT00006264|Biological|aldesleukin|
5817537|NCT00006264|Drug|ganciclovir|
5817538|NCT00006264|Drug|zidovudine|
5817539|NCT00006263|Biological|filgrastim|
5817540|NCT00006263|Drug|carboplatin|
5817541|NCT00006263|Drug|temozolomide|
5817542|NCT00006260|Drug|cisplatin|cisplatin IV over 30 minutes on days 1-3.
5817543|NCT00006260|Drug|etoposide|etoposide IV over 60-90 minutes on days 1-3.
5817544|NCT00006260|Drug|ifosfamide|ifosfamide IV over 30 minutes on days 1-3.
5817545|NCT00006260|Drug|Mesna|Mesna is administered IV over 15 minutes 30 minutes prior to and 4 hours after ifosfamide, then orally at 8 hours post infusion.
5817546|NCT00006258|Biological|filgrastim|
5817547|NCT00006258|Drug|cisplatin|
5817548|NCT00006258|Drug|cyclophosphamide|
5817549|NCT00006258|Drug|etoposide|
5817550|NCT00006258|Drug|methotrexate|
5817551|NCT00006258|Drug|vincristine sulfate|
5817552|NCT00006258|Procedure|adjuvant therapy|
5817553|NCT00006258|Radiation|radiation therapy|
5817554|NCT00006256|Drug|paclitaxel|Patients receive paclitaxel IV over 3 hours every 21 days for 4 courses beginning 3 weeks after completion of the last doxorubicin and cyclophosphamide adjuvant regimen.
5817555|NCT00006256|Procedure|adjuvant therapy|doxorubicin and cyclophosphamide adjuvant regimen
5817556|NCT00006256|Radiation|radiation therapy|Patients also undergo concurrent radiotherapy 5 days a week for approximately 6-7 weeks.
5817557|NCT00006255|Procedure|radiofrequency ablation|Undergo thermal ablation by radiofrequency energy under magnetic resonance guidance.Thermal ablation continues until the entire tumor is treated.
5817558|NCT00006255|Procedure|thermal ablation therapy|Undergo thermal ablation by radiofrequency energy under magnetic resonance guidance.Thermal ablation continues until the entire tumor is treated.
5817559|NCT00006252|Drug|fludarabine phosphate|30 mg/sq m/day IV infusion for 5 days (Days -7 thru -3)
5817560|NCT00006252|Drug|Cyclophosphamide|1 g/sq m/day IV infusion x 3 days (Days -5 thru -3)
5817561|NCT00006252|Biological|PBSC|2-8,000,000/kg CD34+ cells via infusion on Day 0
5817562|NCT00006252|Drug|G-CSF|5 ug/kg/day subQ injection until ANC > 1000/uL for 3 days beginning Day 5
5817563|NCT00006252|Biological|Donor lymphocytes|10,000,000 CD3+ cells/kg via infusion
5817564|NCT00006250|Drug|chlorambucil|
5817565|NCT00006250|Drug|dexamethasone|
5817566|NCT00006250|Drug|fludarabine phosphate|
5817567|NCT00006250|Drug|mitoxantrone hydrochloride|
5817568|NCT00006249|Biological|pegylated interferon alfa|
5817569|NCT00006249|Procedure|adjuvant therapy|
5817570|NCT00006248|Drug|cisplatin|
5817571|NCT00006248|Drug|fluorouracil|
5817572|NCT00006248|Drug|paclitaxel|
5817573|NCT00006246|Drug|busulfan|
5817574|NCT00006245|Drug|alvocidib|
5817575|NCT00006245|Drug|paclitaxel|
5817576|NCT00006244|Drug|melphalan|Given IV
5817577|NCT00006244|Biological|recombinant interferon alfa|Given SC
5817578|NCT00006244|Biological|aldesleukin|Undergo IL2-treated autologous or syngeneic peripheral blood stem infusion
5817579|NCT00006244|Procedure|in vitro-treated peripheral blood stem cell transplantation|Undergo IL2-treated autologous or syngeneic peripheral blood stem infusion
5817580|NCT00006239|Drug|sodium phenylbutyrate|
5817581|NCT00006239|Drug|tretinoin|
5817582|NCT00006237|Biological|interleukin-2|Given IV
5817583|NCT00006237|Biological|filgrastim|Given subcutaneously
5817584|NCT00006237|Biological|interferon alfa|Given IV and subcutaneously
5817585|NCT00006237|Drug|cisplatin|Given IV
5817586|NCT00006237|Drug|dacarbazine|Given IV
5817587|NCT00006237|Drug|vinblastine|Given IV
5817588|NCT00006234|Procedure|peripheral blood stem cell transplantation|
5817589|NCT00006234|Radiation|holmium Ho 166 DOTMP|
5817590|NCT00006233|Biological|therapeutic allogeneic lymphocytes|
5817591|NCT00006233|Drug|cyclosporine|
5817592|NCT00006233|Drug|fludarabine phosphate|
5817593|NCT00006233|Drug|mycophenolate mofetil|
5817594|NCT00006233|Procedure|peripheral blood stem cell transplantation|
5817595|NCT00006233|Radiation|radiation therapy|
5817596|NCT00006232|Drug|dexamethasone|
5817597|NCT00006232|Drug|doxorubicin hydrochloride|
5817598|NCT00006232|Drug|idarubicin|
5817599|NCT00006232|Drug|vincristine sulfate|
5817600|NCT00006231|Procedure|quality-of-life assessment|
5817601|NCT00006231|Procedure|standard follow-up care|
5817602|NCT00006231|Radiation|radiation therapy|
5817603|NCT00006230|Drug|rubitecan|
5817604|NCT00006228|Biological|trastuzumab|Given IV
5817605|NCT00006228|Biological|aldesleukin|Given SC
5817606|NCT00006228|Other|laboratory biomarker analysis|Correlative studies
5817607|NCT00006228|Other|pharmacological study|Correlative studies
5817608|NCT00006227|Drug|Paclitaxel|Given IV
5817609|NCT00006226|Drug|thalidomide|Given PO
5817610|NCT00006226|Other|laboratory biomarker analysis|Correlative studies
5817611|NCT00006221|Drug|ixabepilone|
5817612|NCT00006219|Drug|clarithromycin|
5817613|NCT00006219|Drug|prasterone|
5817614|NCT00006125|Drug|doxorubicin hydrochloride|
5817615|NCT00006125|Drug|topotecan hydrochloride|
5817616|NCT00006124|Drug|celecoxib|Given orally
5817617|NCT00006124|Drug|placebo|Given orally
5817618|NCT00006120|Drug|docetaxel|
5817619|NCT00006120|Drug|paclitaxel|
5817620|NCT00006119|Drug|hydroxyurea|
5817621|NCT00006118|Drug|cisplatin|
5817622|NCT00006118|Drug|gemcitabine hydrochloride|
5817623|NCT00006118|Drug|paclitaxel|
5817624|NCT00006114|Drug|mitoxantrone hydrochloride|
5817625|NCT00006114|Drug|vinorelbine tartrate|
5817626|NCT00006113|Biological|MART-1 antigen|
5817627|NCT00006113|Biological|aldesleukin|
5817628|NCT00006113|Biological|gp100 antigen|
5817629|NCT00006113|Biological|recombinant CD40-ligand|
5817630|NCT00006113|Biological|recombinant interferon gamma|
5817631|NCT00006113|Biological|recombinant interleukin-4|
5817632|NCT00006113|Biological|sargramostim|
5817633|NCT00006113|Biological|therapeutic autologous dendritic cells|
5817634|NCT00006113|Biological|therapeutic tumor infiltrating lymphocytes|
5817635|NCT00006113|Biological|tyrosinase peptide|
5817636|NCT00006113|Radiation|Candida albicans skin test reagent|
5817637|NCT00006110|Biological|trastuzumab|infusion 4 mg/kg load week 1; 2 mg/kg weekly thereafter for 12 weeks
5817638|NCT00006110|Drug|cyclophosphamide|600 mg/m2, intravenous infusion every 3 weeks for four cycles
5817639|NCT00006110|Drug|doxorubicin hydrochloride|60 mg/m2 intravenously, 5-10 minutes, every 3 weeks, up to 12 weeks
5817732|NCT00005987|Procedure|bone marrow ablation with stem cell support|
5817640|NCT00006110|Drug|paclitaxel|90 mg/m2 weekly, intravenously 1 hour after herceptin, given weekly up to 12 weeks or 175 mg/m2, intravenously every 3 weeks, up to 12 weeks (only if not receiving Herceptin®)
5817641|NCT00006110|Procedure|conventional surgery|Surgical excision will take place 12-13 weeks for the neo-adjuvant herceptin setting and 12-13 weeks in the non-herceptin setting. Surgery will take place prior to chemotherapy in the adjuvant herceptin setting
5817642|NCT00006107|Drug|Taxotere|
5817643|NCT00006107|Procedure|Surgery|
5817644|NCT00006107|Radiation|radiation therapy|
5817645|NCT00006105|Drug|amifostine trihydrate|
5817646|NCT00006105|Drug|cisplatin|
5817647|NCT00006105|Drug|gemcitabine hydrochloride|
5817648|NCT00006105|Procedure|adjuvant therapy|
5817649|NCT00006102|Drug|becatecarin|
5817650|NCT00006101|Drug|eflornithine|Take 500mg of DFMO per day for 12 months
5817651|NCT00006101|Drug|Placebo|Take placebo per day for 12 months
5817652|NCT00006100|Biological|aldesleukin|
5817653|NCT00006100|Biological|allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes|
5817654|NCT00006100|Drug|fludarabine phosphate|
5817655|NCT00006100|Procedure|peripheral blood stem cell transplantation|
5817656|NCT00006094|Drug|oxaliplatin|Given IV
5817657|NCT00006094|Drug|fluorouracil|Given IV
5817658|NCT00006094|Radiation|external beam radiation therapy|Undergo external beam radiation therapy
5817659|NCT00006093|Drug|cilengitide|
5817660|NCT00006092|Drug|Arsenic Trioxide|
5817661|NCT00006089|Other|Laboratory Biomarker Analysis|Correlative studies
5817662|NCT00006089|Biological|Trastuzumab|Given IV
5817663|NCT00006078|Dietary Supplement|lycopene|
5817664|NCT00006044|Drug|therapeutic testosterone|
5817665|NCT00006042|Biological|filgrastim|
5817666|NCT00006042|Drug|cyclophosphamide|
5817667|NCT00006042|Drug|fludarabine phosphate|
5817668|NCT00006042|Drug|mycophenolate mofetil|
5817669|NCT00006042|Drug|tacrolimus|
5817670|NCT00006042|Procedure|allogeneic bone marrow transplantation|
5817671|NCT00006042|Radiation|radiation therapy|
5817672|NCT00006040|Biological|filgrastim|
5817673|NCT00006040|Drug|etoposide|
5817674|NCT00006040|Procedure|autologous bone marrow transplantation|
5817675|NCT00006040|Procedure|peripheral blood stem cell transplantation|
5817676|NCT00006040|Radiation|yttrium Y 90 monoclonal antibody M195|
5817677|NCT00006029|Drug|gemcitabine hydrochloride|
5817678|NCT00006029|Drug|pegylated liposomal doxorubicin hydrochloride|
5817679|NCT00006029|Drug|vinorelbine tartrate|
5817680|NCT00006028|Drug|cisplatin|
5817681|NCT00006028|Drug|gemcitabine hydrochloride|
5817682|NCT00006027|Drug|cisplatin|
5817683|NCT00006027|Drug|paclitaxel|
5817684|NCT00006027|Procedure|adjuvant therapy|
5817685|NCT00006027|Radiation|radiation therapy|
5817686|NCT00006025|Drug|irinotecan hydrochloride|
5817687|NCT00006025|Drug|temozolomide|
5817688|NCT00006024|Drug|lomustine|
5817689|NCT00006024|Drug|temozolomide|
5817690|NCT00006022|Biological|aldesleukin|
5817691|NCT00006022|Drug|bryostatin 1|
5817692|NCT00006021|Dietary Supplement|ascorbic acid|
5817693|NCT00006021|Drug|arsenic trioxide|
5817694|NCT00006020|Drug|nelarabine|1.5 gm/m2 IV over 2 hours days 1, 3, 5 q21 days
5817695|NCT00006017|Drug|becatecarin|Arm I: Patients receive rebeccamycin analogue IV over 1 hour on day 1. Arm II: Patients receive rebeccamycin analogue IV over 1 hour on days 1-5. Treatment for both arms repeats every 3 weeks for 6-8 courses in the absence of disease progression or unacceptable toxicity.
5817696|NCT00006016|Drug|thalidomide|Given orally
5817697|NCT00006016|Drug|doxorubicin hydrochloride|Given transarterially (chemoembolization)
5817698|NCT00006016|Other|laboratory biomarker analysis|Correlative studies
5817699|NCT00006015|Biological|trastuzumab|4 mg/kg IV infusion Day 1, then weekly 2 mg/kg IV infusion (on Days 8, 15, & 22)
5817700|NCT00006015|Drug|fluorouracil|500 mg/sq m IV push weekly for 3 weeks, followed by a 1 wk break
5817701|NCT00006015|Drug|leucovorin calcium|500 mg/sq m IV infusion over 2 hours weekly for 3 weeks, then a 1 wk break
5817702|NCT00006015|Drug|oxaliplatin|85 mg/sq m IV infusion over 2 hours Days 1 & 15 of each cycle
5817703|NCT00006011|Drug|Doxorubicin Hydrochloride|Given IV
5817704|NCT00006011|Drug|Cisplatin|Given IV
5817705|NCT00006011|Biological|Filgrastim|Given SC
5817706|NCT00006011|Biological|Pegfilgrastim|Given SC
5817707|NCT00006011|Drug|Paclitaxel|Given IV
5817708|NCT00006010|Drug|docetaxel|
5817709|NCT00006010|Drug|gemcitabine hydrochloride|
5817710|NCT00006007|Drug|gemcitabine hydrochloride|
5817711|NCT00006007|Drug|pemetrexed disodium|
5817712|NCT00006006|Biological|recombinant interferon alfa|
5817713|NCT00006006|Drug|thalidomide|
5817714|NCT00006005|Drug|thalidomide|
5817715|NCT00006004|Drug|carboplatin|
5817716|NCT00006004|Drug|cisplatin|
5817717|NCT00006004|Drug|gemcitabine hydrochloride|
5817718|NCT00006004|Drug|paclitaxel|
5817719|NCT00006003|Drug|semaxanib|Given IV
5817720|NCT00006003|Other|laboratory biomarker analysis|Correlative studies
5817721|NCT00005997|Drug|becatecarin|Cohorts of 3-6 patients receive escalating doses of rebeccamycin analogue until the maximum tolerated dose (MTD) is determined.
5817722|NCT00005990|Drug|tipifarnib|
5817723|NCT00005990|Drug|topotecan hydrochloride|
5817724|NCT00005987|Drug|carmustine|
5817725|NCT00005987|Drug|cyclophosphamide|
5817726|NCT00005987|Drug|dexamethasone|
5817727|NCT00005987|Drug|etoposide|
5817728|NCT00005987|Drug|filgrastim|
5817729|NCT00005987|Drug|mitoxantrone hydrochloride|
5817730|NCT00005987|Drug|recombinant interferon alfa|
5817731|NCT00005987|Drug|sargramostim|
5817822|NCT00005859|Drug|tipifarnib|
5817733|NCT00005987|Procedure|peripheral blood stem cell transplantation|
5817734|NCT00005987|Procedure|radiation therapy|
5817735|NCT00005985|Biological|filgrastim|
5817736|NCT00005985|Drug|carmustine|
5817737|NCT00005985|Drug|cyclophosphamide|
5817738|NCT00005985|Drug|cytarabine|
5817739|NCT00005985|Drug|dexamethasone|
5817740|NCT00005985|Drug|etoposide|
5817741|NCT00005985|Drug|mitoxantrone hydrochloride|
5817742|NCT00005985|Procedure|peripheral blood stem cell transplantation|
5817743|NCT00005985|Radiation|radiation therapy|
5817744|NCT00005984|Drug|cyclophosphamide|intravenously over 2 hours on day 1 and on days -7 and -6
5817745|NCT00005984|Drug|filgrastim|filgrastim (G-CSF) daily subcutaneously (SQ) starting on day 5 and continuing until completion of leukapheresis. Patients also receive G-CSF IV starting on day 0 and continuing until blood counts recover
5817746|NCT00005984|Drug|recombinant interferon alfa|Beginning on Day 1, subcutaneous (SQ) daily administration in the absence of unacceptable toxicity or disease progression
5817747|NCT00005984|Procedure|peripheral blood stem cell transplantation|Patients receive the PBSC transplantation on day 0.
5817748|NCT00005984|Procedure|radiation therapy|total body irradiation twice a day on days -4 through -1
5817749|NCT00005983|Radiation|radiation therapy|
5817750|NCT00005983|Procedure|surgery|surgery
5817751|NCT00005982|Drug|nelarabine|Given IV
5817752|NCT00005982|Other|pharmacological study|Correlative studies
5817753|NCT00005981|Drug|O6-benzylguanine|Patients receive O6-benzylguanine (BG) IV over 1 hour. Treatment continues every 6 weeks in the absence of disease progression or unacceptable toxicity.
5817754|NCT00005981|Drug|carmustine|Carmustine IV over 1 hour (beginning 1 hour after completion of BG infusion) on day 1. Treatment continues every 6 weeks in the absence of disease progression or unacceptable toxicity.
5817755|NCT00005980|Drug|pegylated liposomal doxorubicin hydrochloride|
5817756|NCT00005979|Drug|FOLFIRI regimen|
5817757|NCT00005979|Drug|fluorouracil|
5817758|NCT00005979|Drug|irinotecan hydrochloride|
5817759|NCT00005979|Drug|leucovorin calcium|
5817760|NCT00005976|Drug|carboplatin|
5817761|NCT00005976|Drug|pyrazoloacridine|
5817762|NCT00005973|Drug|BMS-214662|Given IV
5817763|NCT00005973|Other|laboratory biomarker analysis|Correlative studies
5817764|NCT00005970|Drug|Aromatase Inhibition Therapy|Given orally
5817765|NCT00005970|Drug|Cyclophosphamide|Given IV
5817766|NCT00005970|Drug|Doxorubicin Hydrochloride|Given IV
5817767|NCT00005970|Other|Laboratory Biomarker Analysis|Correlative studies
5817768|NCT00005970|Drug|Paclitaxel|Given IV
5817769|NCT00005970|Drug|Tamoxifen Citrate|Given orally
5817770|NCT00005970|Biological|Trastuzumab|Given IV
5817771|NCT00005967|Drug|tipifarnib|
5817772|NCT00005966|Biological|recombinant interferon alfa|
5817773|NCT00005966|Drug|thalidomide|
5817774|NCT00005961|Drug|O6-benzylguanine|
5817775|NCT00005961|Drug|carmustine|
5817776|NCT00005957|Radiation|Standard Breast Irradiation|Standard Breast Irradiation - A dose of 5000 cGy in 25 fractions at a rate of 200 cGy per day, 5 days a week for 5 weeks will be prescribed to the standard tangent fields.
5817777|NCT00005957|Radiation|Breast Radiation plus Regional Radiation|Breast Radiation plus Regional Radiation - A dose of 5000 cGy in 25 fractions at a rate of 200 cGy per day, 5 days a week for 5 weeks will be prescribed to the modified wide tangent fields.
5817778|NCT00005955|Drug|temozolomide|
5817779|NCT00005954|Drug|temozolomide|
5817780|NCT00005952|Biological|filgrastim|
5817781|NCT00005952|Drug|temozolomide|
5817782|NCT00005952|Procedure|peripheral blood stem cell transplantation|
5817783|NCT00005951|Drug|irinotecan hydrochloride|
5817784|NCT00005951|Drug|temozolomide|
5817785|NCT00005949|Biological|aldesleukin|Given SC
5817786|NCT00005949|Biological|gp100:209-217(210M) peptide vaccine|Given SC
5817787|NCT00005949|Other|laboratory biomarker analysis|Correlative studies
5817788|NCT00005945|Drug|cyclophosphamide|Given IV
5817789|NCT00005945|Drug|cytarabine|Given IT
5817790|NCT00005945|Drug|daunorubicin hydrochloride|Given IV
5817791|NCT00005945|Drug|dexamethasone|Given PO
5817792|NCT00005945|Drug|doxorubicin hydrochloride|Dose 25 g/m² IV Days 0, 7, 14, given over a period of 15 minutes to 2 hours
5817793|NCT00005945|Drug|mercaptopurine|Given PO
5817794|NCT00005945|Drug|methotrexate|Given PO and IT
5817795|NCT00005945|Drug|pegaspargase|Given IM
5817796|NCT00005945|Drug|thioguanine|Given PO
5817797|NCT00005945|Drug|vincristine sulfate|Given IV
5817798|NCT00005945|Radiation|radiation therapy|Undergo radiation therapy
5817799|NCT00005941|Biological|therapeutic allogeneic lymphocytes|
5817800|NCT00005941|Drug|cyclosporine|
5817801|NCT00005941|Drug|fludarabine phosphate|
5817802|NCT00005941|Drug|mycophenolate mofetil|
5817803|NCT00005941|Procedure|peripheral blood stem cell transplantation|
5817804|NCT00005941|Radiation|radiation therapy|
5817805|NCT00005879|Drug|arzoxifene|one tablet daily
5817806|NCT00005879|Drug|Placebo|matched tablet dialy
5817807|NCT00005878|Drug|celecoxib|
5817808|NCT00005867|Biological|bleomycin sulfate|
5817809|NCT00005867|Drug|CHOP regimen|
5817810|NCT00005867|Drug|cyclophosphamide|
5817811|NCT00005867|Drug|doxorubicin hydrochloride|
5817812|NCT00005867|Drug|etoposide|
5817813|NCT00005867|Drug|mitoxantrone hydrochloride|
5817814|NCT00005867|Drug|prednisolone|
5817815|NCT00005867|Drug|vincristine sulfate|
5817816|NCT00005863|Biological|filgrastim|
5817817|NCT00005863|Drug|cytarabine|
5817818|NCT00005863|Drug|daunorubicin hydrochloride|
5817819|NCT00005863|Drug|etoposide|
5817820|NCT00005863|Drug|fludarabine phosphate|
5817821|NCT00005863|Drug|tretinoin|
5817823|NCT00005858|Biological|LMB-9 immunotoxin|
5817824|NCT00005856|Drug|oxaliplatin|Given IV
5817825|NCT00005856|Other|pharmacological study|Correlative studies
5817826|NCT00005855|Drug|carmustine|
5817827|NCT00005855|Drug|efaproxiral|
5817828|NCT00005853|Biological|anti-thymocyte globulin|
5817829|NCT00005853|Biological|etanercept|
5817830|NCT00005851|Drug|fludarabine phosphate|Given IV
5817831|NCT00005851|Radiation|total-body irradiation|Undergo TBI
5817832|NCT00005851|Procedure|nonmyeloablative allogeneic hematopoietic stem cell transplantation|Undergo nonmyeloablative allogeneic PBSC transplantation
5817833|NCT00005851|Drug|cyclosporine|Given PO or IV
5817834|NCT00005851|Drug|mycophenolate mofetil|Given PO or IV
5817835|NCT00005851|Procedure|peripheral blood stem cell transplantation|Undergo nonmyeloablative allogeneic PBSC transplantation
5817836|NCT00005851|Biological|therapeutic allogeneic lymphocytes|Undergo DLI
5817837|NCT00005851|Other|laboratory biomarker analysis|Correlative studies
5817838|NCT00005850|Drug|cisplatin|80 mg/m2 administered by intravenous (IV) over 30 minutes on Day 1 following the gemcitabine infusion. Treatment repeated every 21 days for a total of 6 cycles.
5817839|NCT00005850|Drug|fluoxetine|10 mg PO QD (by mouth once daily) starting on week 2 (day 8) and continuing for 7 weeks (days 8-57). After 7 weeks of fluoxetine treatment (day 57), further use of fluoxetine is at the discretion of the patient and physician.
5817840|NCT00005850|Drug|gemcitabine hydrochloride|1000 mg/m2 intravenous (IV) administered by IV over 30 minutes on days 1 and 8. Repeat treatment every 21 days for a total of 6 cycles.
5817841|NCT00005847|Biological|recombinant interferon alfa|
5817842|NCT00005847|Drug|estramustine phosphate sodium|
5817843|NCT00005847|Drug|isotretinoin|
5817844|NCT00005847|Drug|mitoxantrone hydrochloride|
5817845|NCT00005847|Drug|paclitaxel|
5817846|NCT00005847|Drug|vinorelbine ditartrate|
5817847|NCT00005844|Drug|oxaliplatin|
5817848|NCT00005840|Drug|Paclitaxel|Given IV
5817849|NCT00005840|Drug|Cisplatin|Given IV
5817850|NCT00005840|Radiation|Radiation Therapy|Undergo whole abdominal radiation therapy
5817851|NCT00005838|Drug|shark cartilage extract AE-941|Given orally
5817852|NCT00005838|Other|placebo|Given orally
5817853|NCT00005838|Drug|cisplatin|Given IV
5817854|NCT00005838|Drug|vinorelbine tartrate|Given IV
5817855|NCT00005838|Drug|carboplatin|Given IV
5817856|NCT00005838|Drug|paclitaxel|Given IV
5817857|NCT00005838|Radiation|radiation therapy|Undergo radiotherapy
5817858|NCT00005835|Drug|buthionine sulfoximine|Dose fixed at a bolus of 3 gm/M2 given over 30 minutes followed by a continuous infusion of 1 gm/M2/hour for 72 hours (total 72.5 hours).Total daily infusion dose (minus the initial bolus)will be 24 gm/m2/day.
5817859|NCT00005835|Drug|melphalan|The dose level of melphalan will be assigned at study entry onto protocol. There will be 6 dose levels ranging from 20mg/m2/day x 2 days (dose level 1a) to 62.5 mg/m2/day x 2 days (dose level 6a). The starting dose level will be 1a, with a decrease to level 0a (15mg/m2/day x2 days) if there is unacceptable toxicity.
5817860|NCT00005835|Procedure|Peripheral blood stem cell infusion|Stem cells will be infused intravenously on day 0 , 24 hours after BSO continuous infusion is completed.Infused within 1.5 hours of thawing via a central venous catheter over 15-30 minutes.
5817861|NCT00005835|Other|Filgrastim|5 microgram/kg/day , subcutaneous or intravenous, given daily beginning day 0. First dose to begin 4 hours after completion of stem cell infusion and then to continue till ANC >/= 1500 mm3 for three consecutive days.
5817862|NCT00005831|Biological|trastuzumab|Given IV
5817863|NCT00005831|Drug|paclitaxel|Given IV
5817864|NCT00005831|Drug|carboplatin|Given IV
5817865|NCT00005831|Drug|gemcitabine hydrochloride|Given IV
5817866|NCT00005831|Other|laboratory biomarker analysis|Correlative studies
5817867|NCT00005830|Drug|Doxorubicin Hydrochloride|Given IV
5817868|NCT00005830|Drug|Cisplatin|Given IV
5817869|NCT00005830|Radiation|Radiation Therapy|Undergo radiation therapy
5817870|NCT00005825|Drug|cisplatin|
5817871|NCT00005825|Drug|mitomycin C|
5817872|NCT00005825|Drug|tretinoin|
5817873|NCT00005825|Drug|vinorelbine tartrate|
5817874|NCT00005824|Biological|filgrastim|
5817875|NCT00005824|Drug|busulfan|
5817876|NCT00005824|Drug|cyclophosphamide|
5817877|NCT00005824|Procedure|peripheral blood stem cell transplantation|
5817878|NCT00005823|Drug|cytarabine|
5817879|NCT00005823|Drug|daunorubicin hydrochloride|
5817880|NCT00005823|Drug|etoposide|
5817881|NCT00005823|Drug|hydroxyurea|
5817882|NCT00005823|Drug|idarubicin|
5817883|NCT00005823|Drug|mitoxantrone hydrochloride|
5817884|NCT00005823|Drug|thioguanine|
5817885|NCT00005823|Drug|tretinoin|
5817886|NCT00005823|Drug|valspodar|
5817887|NCT00005822|Drug|doxorubicin hydrochloride|Patients receive doxorubicin IV continuously over 72 hours on days 1-3 of course 1. For all subsequent courses, patients receive doxorubicin as in course 1. Treatment repeats every 21 days for 5 courses in the absence of disease progression or unacceptable toxicity.
5817888|NCT00005822|Drug|semaxanib|For all subsequent courses, after course 1 patients SU5416 IV over 1 hour twice weekly (on days 1 and 4) beginning on week 2 of course 2. Treatment repeats every 21 days for 5 courses in the absence of disease progression or unacceptable toxicity.
5817889|NCT00005822|Procedure|conventional surgery|Patients undergo a modified radical mastectomy.
5817890|NCT00005822|Radiation|radiation therapy|Patients undergo radiotherapy to the chest wall and regional lymph nodes.
5817891|NCT00005822|Drug|tamoxifen|Patients with estrogen or progesterone receptor positive disease receive oral tamoxifen for 5 years after radiotherapy.
5817892|NCT00005821|Drug|patent blue V dye|
5817893|NCT00005821|Procedure|conventional surgery|
5817894|NCT00005821|Procedure|lymphangiography|
5817895|NCT00005821|Procedure|radionuclide imaging|
5817896|NCT00005821|Procedure|sentinel lymph node biopsy|
5822962|NCT00002068|Drug|Fluconazole|
5817897|NCT00005821|Radiation|Technetium Tc 99m human serum albumin colloid|
5817898|NCT00005819|Drug|cisplatin|Patients receive cisplatin IV over 30 minutes on day 7. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.Cohorts of 3-6 patients receive escalating doses of paclitaxel and cisplatin until the maximum tolerated dose (MTD) is determined.
5817899|NCT00005819|Drug|fenretinide|Patients receive oral fenretinide twice daily for 7 days. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
5817900|NCT00005819|Drug|paclitaxel|Patients receive paclitaxel IV over 3 hours. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.Cohorts of 3-6 patients receive escalating doses of paclitaxel and cisplatin until the maximum tolerated dose (MTD) is determined.
5817901|NCT00005817|Drug|becatecarin|Given IV
5817902|NCT00005817|Other|laboratory biomarker analysis|Correlative studies
5817903|NCT00005815|Drug|temozolomide|
5817904|NCT00005815|Drug|thalidomide|
5817905|NCT00005812|Drug|temozolomide|
5817906|NCT00005811|Drug|topotecan hydrochloride|Given IT
5817907|NCT00005811|Other|laboratory biomarker analysis|Correlative studies
5817908|NCT00005808|Drug|motexafin lutetium|Given IV
5817909|NCT00005808|Drug|photodynamic therapy|Undergo laser therapy
5817910|NCT00005808|Procedure|loop electrosurgical excision procedure|Undergo LEEP
5817911|NCT00005808|Other|laboratory biomarker analysis|Correlative studies
5817912|NCT00005807|Drug|BMS-247550|anticancer agent for the treatment of patients with malignant tumors.
5817913|NCT00005803|Procedure|Autologous Hematopoietic Stem Cell Transplantation|Undergo autologous transplantation
5817914|NCT00005803|Procedure|Autologous-Allogeneic Tandem Hematopoietic Stem Cell Transplantation|Undergo autologous-allogeneic tandem hematopoietic stem cell transplantation
5817915|NCT00005803|Drug|Carmustine|Given IV
5817916|NCT00005803|Drug|Cyclophosphamide|Given IV
5817917|NCT00005803|Drug|Cyclosporine|Given PO
5817918|NCT00005803|Drug|Cytarabine|Given IV
5817919|NCT00005803|Drug|Etoposide|Given IV
5817920|NCT00005803|Drug|Fludarabine Phosphate|Given IV
5817921|NCT00005803|Other|Laboratory Biomarker Analysis|Correlative studies
5817922|NCT00005803|Drug|Melphalan|Given IV
5817923|NCT00005803|Drug|Mycophenolate Mofetil|Given PO
5817924|NCT00005803|Procedure|Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|Undergo allogeneic transplantation
5817925|NCT00005803|Procedure|Peripheral Blood Stem Cell Transplantation|Undergo allogeneic transplantation
5817926|NCT00005803|Biological|Therapeutic Autologous Lymphocytes|IV donor lymphocyte infusion
5817927|NCT00005803|Radiation|Total-Body Irradiation|Undergo radiotherapy
5817928|NCT00005802|Biological|aldesleukin|
5817929|NCT00005802|Biological|filgrastim|
5817930|NCT00005802|Biological|therapeutic allogeneic lymphocytes|
5817931|NCT00005802|Drug|cytarabine|
5817932|NCT00005802|Drug|etoposide|
5817933|NCT00005802|Drug|fludarabine phosphate|
5817934|NCT00005802|Drug|methotrexate|
5817935|NCT00005802|Drug|mitoxantrone hydrochloride|
5817936|NCT00005802|Drug|therapeutic hydrocortisone|
5817937|NCT00005802|Radiation|radiation therapy|
5817938|NCT00005797|Drug|busulfan|administered on Day -7 through Day -4. The total dose is 12.8 mg/kg
5817939|NCT00005797|Drug|Cyclophosphamide|administered at a dose of 60 mg/kg on each of two successive days (Days -3 and -2)
5817940|NCT00005797|Drug|VP-16|administered as a single infusion on Day -3. The dose is 60 mg/kg and is calculated on actual body weight unless the patient's weight is >/= 150% of IBW, in which case adjusted body weight will be used.
5817941|NCT00005797|Radiation|Fractionated Total Body Irradiation (FTBI)|FTBI is performed on day -7 through day -4. The total dose of radiation is 1,320 cGy.
5817942|NCT00005788|Biological|aldesleukin|
5817943|NCT00005787|Biological|epoetin alfa|
5817944|NCT00005787|Biological|filgrastim|
5817945|NCT00005787|Biological|recombinant flt3 ligand|
5817946|NCT00005787|Biological|recombinant interleukin-3|
5817947|NCT00005787|Biological|sargramostim|
5817948|NCT00005787|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5817949|NCT00005786|Drug|arsenic trioxide|Given IV
5817950|NCT00005786|Other|laboratory biomarker analysis|Correlative studies
5817951|NCT00005647|Drug|paclitaxel|Patients receive paclitaxel IV over one hour on day 1. Treatment continues weekly in the absence of disease progression or unacceptable toxicity.
5817952|NCT00005647|Drug|semaxanib|Patients receive SU5416 IV over one hour on days 1 and 4. Treatment continues weekly in the absence of disease progression or unacceptable toxicity.
5817953|NCT00005644|Drug|gemcitabine hydrochloride|
5817954|NCT00005644|Drug|paclitaxel|
5817955|NCT00005639|Drug|Azacitidine Injection|subcutaneous injection (SC)
5817956|NCT00005639|Drug|sodium phenylbutyrate|continuous intravenous (CIV)
5817957|NCT00005638|Drug|cisplatin|
5817958|NCT00005638|Drug|irinotecan hydrochloride|
5817959|NCT00005638|Radiation|radiation therapy|
5817960|NCT00005637|Drug|carmustine|
5817961|NCT00005637|Drug|temozolomide|
5817962|NCT00005627|Drug|carboplatin|
5817963|NCT00005627|Drug|docetaxel|
5817964|NCT00005627|Drug|estramustine phosphate sodium|
5817965|NCT00005623|Drug|cyproterone acetate|
5817966|NCT00005623|Procedure|quality-of-life assessment|
5817967|NCT00005622|Drug|cyclophosphamide|Cyclophosphamide is administered at a dose of 60 mg/kg on each of two successive days (Days -6 and -5)
5817968|NCT00005622|Radiation|TBI|FTBI is performed on day -3 through day 0 The total dose of radiation is 1,320 cGy.
5817969|NCT00005617|Biological|dendritic cell-MART-1 peptide vaccine|Number DC: dependent on the group route of immunization: dependent on the group subjects will receive 3 biweekly vaccinations. In case of grade III-IV toxicity in 1/3 subjects at any dose group or route, up to 6 subjects will be included in that group.
5818047|NCT00005095|Procedure|study of high risk factors|Subjects will be assessed for high risk factors.
5817970|NCT00005617|Procedure|leukapheresis|Patients require a single leukapheresis to obtain 2x10^9 PBL, which are cryopreserved in RPMI 1640, 20% autologous serum, 10% DMSO. Aliquots are thawed at days -7, 7 and 21 for the first, second, and third immunizations respectively. Blood is drawn at the time of leukapheresis and on the day of the first vaccination for autologous serum, which is sufficient for the cell cultures of all patient groups.
5817971|NCT00005606|Biological|allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes|
5817972|NCT00005606|Biological|autologous Epstein-Barr virus-specific cytotoxic T lymphocytes|
5817973|NCT00005603|Drug|asparaginase|
5817974|NCT00005603|Drug|cyclophosphamide|
5817975|NCT00005603|Drug|cytarabine|
5817976|NCT00005603|Drug|daunorubicin hydrochloride|
5817977|NCT00005603|Drug|dexamethasone|
5817978|NCT00005603|Drug|doxorubicin hydrochloride|
5817979|NCT00005603|Drug|mercaptopurine|
5817980|NCT00005603|Drug|methotrexate|
5817981|NCT00005603|Drug|prednisone|
5817982|NCT00005603|Drug|thioguanine|
5817983|NCT00005603|Drug|vincristine sulfate|
5817984|NCT00005602|Drug|carboplatin|
5817985|NCT00005602|Drug|cereport|
5817986|NCT00005602|Radiation|radiation therapy|
5817987|NCT00005601|Biological|rituximab|
5817988|NCT00005601|Drug|cisplatin|
5817989|NCT00005601|Drug|cytarabine|
5817990|NCT00005601|Drug|dexamethasone|
5817991|NCT00005601|Drug|sargramostim|
5817992|NCT00005600|Procedure|management of therapy complications|
5817993|NCT00005599|Drug|bryostatin 1|
5817994|NCT00005599|Drug|paclitaxel|
5817995|NCT00005597|Drug|temozolomide|200 mg/m^2/day, PO, on Days 1-5 of each 28 day cycle.
5817996|NCT00005596|Drug|cyclophosphamide|
5817997|NCT00005596|Drug|cytarabine|
5817998|NCT00005596|Drug|daunorubicin hydrochloride|30 mg/m2 IV Day 1 of weeks 16, 17, and 18. Give Week 16 dose if ANC ≥ 500/μL and platelets ≥ 75,000/μL. Continue to give during Weeks 17 and 18, even in the face of uncomplicated myelosuppression
5817999|NCT00005596|Drug|dexamethasone|6 mg/m2/day divided BID for 7 days during weeks 8 and 17.
5818000|NCT00005596|Drug|leucovorin calcium|5 mg/m2/dose of leucovorin will be given PO q12h x 2 doses beginning 48 hours after the start of the MTX.
5818001|NCT00005596|Drug|mercaptopurine|50 mg/m2 dose po qhs Weeks 5 through 13 (total 9 wks) and from Week 24 until the end of consolidation. Only hold for uncomplicated myelosuppression, only if IV MTX course is delayed, until ANC > 500/μL and platelets > 75,000/uL
5818002|NCT00005596|Drug|methotrexate|"IV: 1 gm/m2 given as a 200 mg/m2 bolus over 20 min followed by 800 mg/m2 over 23.6 hours given during Weeks 7, 10, 13, 16, 19, and 22.~IT: Doses by age, Weeks 7, 10, 13, 16, 19 and 22."
5818003|NCT00005596|Drug|pegaspargase|2,500 IU/m2 will be given IM x 1 on Days 2,3,or 4 of Week 16; > or = 1 day after the IT MTX
5818004|NCT00005596|Drug|thioguanine|60 mg/m2 po qhs during Weeks 20 and 21 (total 14 days). Start week 20 when ANC > or = 500/ul and platelets > or = 75,000/uL. Continue to give all 14 doses despite uncomplicated myelosuppression.
5818005|NCT00005596|Drug|vincristine sulfate|1.5 mg/m2 IV on Day 1 of Weeks 8, 9, 17 and 18 (max 2 mg)
5818006|NCT00005590|Drug|levofloxacin|
5818007|NCT00005589|Biological|filgrastim|
5818008|NCT00005589|Biological|rituximab|
5818009|NCT00005589|Drug|carmustine|
5818010|NCT00005589|Drug|cyclophosphamide|
5818011|NCT00005589|Drug|cytarabine|
5818012|NCT00005589|Drug|etoposide|
5818013|NCT00005589|Drug|melphalan|
5818014|NCT00005589|Procedure|bone marrow ablation with stem cell support|
5818015|NCT00005589|Procedure|peripheral blood stem cell transplantation|
5818016|NCT00005586|Drug|L-leucovorin|
5818017|NCT00005586|Drug|fluorouracil|
5818018|NCT00005586|Procedure|adjuvant therapy|
5818019|NCT00005585|Drug|cyclophosphamide|Given IV
5818020|NCT00005585|Drug|cytarabine|Deoxycytidine analogue which is metabolized to ARA-CTP, a substance which inhibits DNA polymerase.
5818021|NCT00005585|Drug|daunorubicin hydrochloride|Given IV
5818022|NCT00005585|Drug|dexamethasone|Dexamethasone is a synthetic fluorinated glucocorticoid devoid of mineralocorticoid effects.
5818023|NCT00005585|Drug|leucovorin calcium|Synthetic d,l-5 CHO tetrahydrofolate, which is used to bypass the inhibition of dihydrofolate reductase by Methotrexate (MTX)
5818024|NCT00005585|Drug|mercaptopurine|An analogue of the nucleic acid constituent adenine and the physiological purine base hypoxanthine
5818025|NCT00005585|Drug|methotrexate|A folate analogue which inhibits the enzyme dihydrofolate reductase, haltin g DNA, RNA, and protein synthesis
5818026|NCT00005585|Drug|pegaspargase|E-Coli asparaginase deaminates asparagine, thus, is lethal for cells which cannot synthesize asparagine.
5818027|NCT00005585|Drug|thioguanine|Given orally
5818028|NCT00005585|Drug|vincristine sulfate|Given IV
5818029|NCT00005584|Biological|bleomycin sulfate|
5818030|NCT00005584|Drug|ABVD regimen|
5818031|NCT00005584|Drug|BEACOPP regimen|
5818032|NCT00005584|Drug|epirubicin hydrochloride|
5818033|NCT00005584|Drug|prednisone|
5818034|NCT00005584|Drug|vinblastine sulfate|
5818035|NCT00005584|Radiation|radiation therapy|
5818036|NCT00005583|Drug|cisplatin|
5818037|NCT00005583|Drug|doxorubicin hydrochloride|
5818038|NCT00005583|Drug|epirubicin hydrochloride|
5818039|NCT00005583|Procedure|adjuvant therapy|
5818040|NCT00005583|Procedure|conventional surgery|
5818041|NCT00005583|Radiation|radiation therapy|
5818042|NCT00005580|Drug|bryostatin 1|
5818043|NCT00005580|Drug|fludarabine phosphate|
5818044|NCT00005579|Drug|dolastatin 10|
5818045|NCT00005095|Other|laboratory biomarker analysis|Subject's blood collected at their follow-up blood draw will be assessed for biomarkers that could lead to a panel for detecting early stage ovarian cancer.
5818046|NCT00005095|Other|screening questionnaire administration|Questionnaires designed to assess quality of life for women at increased risk of ovarian cancer will be administered to the subjects. Clinical data will also be collected.
5818051|NCT00005087|Procedure|conventional surgery|
5818052|NCT00005087|Radiation|radiation therapy|
5818053|NCT00005079|Procedure|conventional surgery|
5818054|NCT00005074|Drug|alvocidib|
5818055|NCT00005067|Drug|motexafin lutetium|Given IV
5818056|NCT00005067|Drug|photodynamic therapy|Undergo photodynamic therapy
5818057|NCT00005062|Radiation|radiation therapy|
5818058|NCT00005060|Drug|Taxotere-Cisplatin-5FU|Preoperatively
5818059|NCT00005060|Drug|Immediate surgery|Immediate surgery followed by Taxotere-Cisplatin-5FU
5818060|NCT00005052|Biological|GM2-KLH vaccine|
5818061|NCT00005052|Biological|QS21|
5818062|NCT00005052|Procedure|adjuvant therapy|
5818063|NCT00005051|Drug|carboplatin|
5818064|NCT00005051|Drug|cisplatin|
5818065|NCT00005051|Drug|paclitaxel|
5818066|NCT00005051|Drug|topotecan hydrochloride|
5818067|NCT00005049|Drug|carboplatin|
5818068|NCT00005049|Drug|cisplatin|
5818069|NCT00005049|Drug|floxuridine|
5818070|NCT00005047|Drug|cisplatin|
5818071|NCT00005047|Drug|doxorubicin hydrochloride|
5818072|NCT00005047|Drug|methotrexate|
5818073|NCT00005047|Drug|vinblastine|
5818074|NCT00005044|Drug|Casodex|Orally at a dose of one 50 mg tablet per day started within (before or after) 14 days of the first LHRH agonist injection.
5818075|NCT00005044|Drug|Eulexin|Orally at a dose of two 125 mg capsules three times a day for a total daily dose of 750 mg (six capsules) started within (before or after) 14 days of the first LHRH agonist injection.
5818076|NCT00005044|Drug|LHRH agonist|LHRH agonist of choice. The manufacturer's instructions should be followed.
5818077|NCT00005044|Radiation|radiation therapy|[Prostate and any extraprostatic tumor extension + 1.0-1.5 cm margin receives 70.2 Gy (1.8 Gy/day x 39 fractions, five days/week)] OR [regional nodes, prostate and seminal vesicles + 1.0-1.5 cm margin will receive 46.8 Gy (1.8 Gy/day x 26 fractions, five days/week), followed by a 23.4 Gy (1.8 Gy/day x 13 fractions, five days/week) boost to the prostate and any extraprostatic tumor extension + 1.0-1.5 cm margin]
5818078|NCT00005039|Biological|recombinant fowlpox-prostate specific antigen vaccine|Given IM
5818079|NCT00005039|Biological|recombinant vaccinia prostate-specific antigen vaccine|Given intradermally
5818080|NCT00005039|Other|laboratory biomarker analysis|Correlative studies
5818081|NCT00005038|Biological|aldesleukin|
5818082|NCT00005038|Drug|histamine dihydrochloride|
5818083|NCT00005036|Drug|irinotecan hydrochloride|Given IV
5818084|NCT00005036|Drug|oxaliplatin|Given IV
5818085|NCT00005036|Drug|leucovorin calcium|Given IV
5818086|NCT00005036|Drug|fluorouracil|Given IV
5818087|NCT00005036|Procedure|quality-of-life assessment|Ancillary studies
5818088|NCT00005033|Biological|trastuzumab|
5818089|NCT00005033|Procedure|conventional surgery|
5818090|NCT00004936|Drug|iodinated contrast dye|
5818091|NCT00004936|Procedure|computed tomography|
5818092|NCT00004936|Procedure|magnetic resonance imaging|
5818093|NCT00004936|Radiation|gadopentetate dimeglumine|
5818094|NCT00004935|Drug|Herceptin™ (Her)|Herceptin™ (Her) loading dose 4 mg/kg iv, followed by 2 mg/kg iv weekly or loading dose 8 mg/kg iv, followed by 6 mg/kg iv every 3 weeks; at time of progression add chemotherapy
5818095|NCT00004935|Drug|Herceptin™ (Her) + chemo|Herceptin™ (Her) loading dose 4 mg/kg iv, followed by 2 mg/kg iv weekly or loading dose 8 mg/kg iv, followed by 6 mg/kg iv every 3 weeks, and chemotherapy
5818096|NCT00004934|Drug|carboplatin|
5818097|NCT00004934|Drug|epirubicin hydrochloride|
5818098|NCT00004934|Drug|paclitaxel|
5818099|NCT00004934|Procedure|conventional surgery|
5818100|NCT00004932|Drug|imatinib mesylate|
5818101|NCT00004930|Drug|doxorubicin hydrochloride|
5818102|NCT00004924|Drug|irinotecan hydrochloride|
5818103|NCT00004924|Drug|paclitaxel|
5818104|NCT00004921|Biological|filgrastim|
5818105|NCT00004921|Drug|carboplatin|
5818106|NCT00004921|Drug|cyclophosphamide|
5818107|NCT00004921|Drug|melphalan|
5818108|NCT00004921|Drug|paclitaxel|
5818109|NCT00004921|Procedure|adjuvant therapy|
5818110|NCT00004921|Procedure|bone marrow ablation with stem cell support|
5818111|NCT00004921|Procedure|peripheral blood stem cell transplantation|
5818112|NCT00004920|Drug|cisplatin|
5818113|NCT00004920|Drug|raltitrexed|
5818114|NCT00004918|Biological|PR1 leukemia peptide vaccine|Given SC
5818115|NCT00004918|Drug|Montanide ISA 51 VG|Given SC
5818116|NCT00004918|Biological|sargramostim|Given SC
5818117|NCT00004918|Other|laboratory biomarker analysis|Correlative studies
5818118|NCT00004917|Biological|epoetin alfa|
5818119|NCT00004917|Drug|cisplatin|
5818120|NCT00004917|Radiation|radiation therapy|
5818121|NCT00004907|Drug|busulfan|
5818122|NCT00004907|Drug|cyclophosphamide|
5818123|NCT00004907|Drug|etoposide|
5818124|NCT00004907|Procedure|allogeneic bone marrow transplantation|
5818125|NCT00004907|Procedure|bone marrow ablation with stem cell support|
5818126|NCT00004907|Procedure|peripheral blood stem cell transplantation|
5818127|NCT00004907|Radiation|radiation therapy|
5818128|NCT00004899|Biological|filgrastim|
5818129|NCT00004899|Drug|busulfan|
5818130|NCT00004899|Drug|etoposide|
5818131|NCT00004899|Procedure|autologous bone marrow transplantation|
5818132|NCT00004896|Drug|busulfan|
5818133|NCT00004896|Drug|cyclophosphamide|
5818134|NCT00004896|Procedure|allogeneic bone marrow transplantation|
5818135|NCT00004896|Procedure|bone marrow ablation with stem cell support|
5818136|NCT00004896|Radiation|radiation therapy|
5818137|NCT00004891|Drug|chemotherapy|
5818138|NCT00004891|Procedure|computed tomography|
5818139|NCT00004891|Procedure|conventional surgery|
5818140|NCT00004891|Procedure|neoadjuvant therapy|
5818141|NCT00004891|Procedure|positron emission tomography|
5818142|NCT00004891|Procedure|radionuclide imaging|
5818143|NCT00004891|Radiation|fludeoxyglucose F 18|
5818144|NCT00004891|Radiation|radiation therapy|
5818145|NCT00004888|Drug|pegylated liposomal doxorubicin hydrochloride|Given IV
5818146|NCT00004888|Drug|docetaxel|Given IV
5818147|NCT00004888|Biological|trastuzumab|Given IV
5818148|NCT00004888|Other|laboratory biomarker analysis|Correlative studies
5818149|NCT00004879|Biological|panitumumab|
5818150|NCT00004876|Drug|carboplatin|
5818151|NCT00004876|Drug|thalidomide|
5818152|NCT00004873|Drug|cisplatin|
5818153|NCT00004873|Drug|docetaxel|
5818154|NCT00004873|Drug|epirubicin hydrochloride|
5818155|NCT00004873|Drug|fluorouracil|
5818156|NCT00004871|Drug|azacitidine|
5818157|NCT00004871|Drug|sodium phenylbutyrate|
5818158|NCT00004867|Procedure|conventional surgery|
5818159|NCT00004867|Procedure|positron emission tomography|
5818160|NCT00004867|Procedure|radionuclide imaging|
5818161|NCT00004867|Radiation|fludeoxyglucose F 18|
5818162|NCT00004867|Drug|chemotherapy|
5818163|NCT00004867|Radiation|Radiotherapy|
5818164|NCT00004866|Drug|exatecan mesylate|
5818165|NCT00004859|Drug|carboplatin|Induction Chemotherapy dosing: AUC=6.0, 15-30 min IV infusion immediately following paclitaxel, Day 1 and Day 22. Concurrent Chemotherapy / Radiotherapy dosing, AUC=2; 15- 30 minutes IV infusion immediately following paclitaxel; administered weekly during radiotherapy
5818166|NCT00004859|Drug|paclitaxel|Induction chemotherapy dosing: 225 mg/m² (3 hour infusion) Day 1 and Day 22. Concurrent Chemotherapy / Radiotherapy dosing: 45 mg/m2; administered weekly during radiotherapy over one hour
5818167|NCT00004859|Drug|thalidomide|Induction Chemotherapy dosing: oral daily, starting Day 1 for 24 months or until disease progression. Concurrent Chemotherapy / Radiotherapy dosing: oral daily, begin with 200 mg thalidomide as a single dose at bedtime. The dose is then increased by 100 mg every week as tolerated up to a total dose of 1000 mg.
5818168|NCT00004859|Radiation|radiation therapy|Radiation therapy started between days 43-50 from day 1 of cycle 1. The primary tumor and areas of known nodal disease received 60 Gy at 2.0 Gy fractions, 5 fractions/week for 30 fractions over 6 weeks to the post chemotherapy tumor volume as seen on computed tomography (CT). The initial 50 Gy was delivered to target volume (TV). The final 10 Gy was delivered to a reduced volume targeting defined by TV
5818169|NCT00004262|Procedure|conventional surgery|
5818170|NCT00004262|Radiation|3-dimensional conformal radiation therapy|
5818171|NCT00004262|Radiation|stereotactic radiosurgery|
5818172|NCT00004262|Drug|motexafin gadolinium|Given IV
5818173|NCT00004262|Procedure|magnetic resonance imaging|Undergo MRI with both the clinical 1.5 Tesla and research 8 Tesla magnets
5818174|NCT00004262|Procedure|spectroscopy|Undergo plasma-atomic emission spectroscopy (DCP-AES)
5818175|NCT00004259|Drug|BCNU 80mg/m2|BCNU 80 mg/m2 will be administered as an intravenous infusion on days 1, 2, and 3 of the first week of radiotherapy and on days 56, 57, and 58, then every eight weeks for four more cycles for a total of 6 cycles (maximum BCNU dose 1440 mg/m2).
5818176|NCT00004259|Drug|TMZ 200mg/m2|200 mg/m2 orally on days 1-5 of the first week of radiotherapy. Repeat every 28 days for a total of 12 cycles.
5818177|NCT00004259|Radiation|radiation therapy|1.8 Gy fractions (to isocenter), 1 fraction per day, 5 days per week to a dose of 59.4 Gy in 33 fractions.
5818178|NCT00004259|Drug|CCNU|CCNU at 130 mg/m2 orally every 8 weeks for a total of 6 cycles. Administered on day 1 of the first week of radiotherapy and on day 56, then administered every 8 weeks for four more cycles for a total of 6 cycles.
5818179|NCT00004259|Drug|BCNU 150mg/m2|BCNU 150 mg/m2 will be administered as an intravenous infusion on day 5 of radiotherapy, and it will be repeated every eight weeks for a total of six cycles (maximum total BCNU dose 900 mg/m2).
5818180|NCT00004259|Drug|BCNU 200mg/m2|BCNU 200 mg/m2 will be administered as an intravenous infusion on day 1 of radiotherapy and will be repeated every six weeks for a total of 6 cycles (maximum BCNU dose 1200 mg/m2).
5818181|NCT00004259|Drug|TMZ 150mg/m2 six 6-week cycles|150 mg/m2 orally on days 1-5 of the first week of radiotherapy. Repeat for a total of six 6-week cycles
5818182|NCT00004259|Drug|TMZ 150mg/m2 six 8-week cycles|150 mg/m2 orally on days 1-5 of the first week of radiotherapy. Repeat for a total of six 8-week cycles
5818183|NCT00004250|Biological|dactinomycin|
5818184|NCT00004250|Drug|isolated limb perfusion|
5818185|NCT00004250|Drug|melphalan|
5818186|NCT00004245|Drug|sodium salicylate|
5818187|NCT00004244|Biological|recombinant interferon alfa|
5818188|NCT00004244|Biological|recombinant interleukin-12|
5818189|NCT00004241|Drug|tanespimycin|Given IV
5818190|NCT00004241|Other|pharmacological study|Correlative studies
5818191|NCT00004237|Drug|cyclophosphamide|
5818192|NCT00004237|Drug|doxorubicin hydrochloride|
5818193|NCT00004237|Drug|epirubicin hydrochloride|
5818194|NCT00004237|Drug|mitoxantrone hydrochloride|
5818195|NCT00004237|Drug|vinorelbine tartrate|
5818196|NCT00004237|Procedure|conventional surgery|
5818197|NCT00004237|Radiation|radiation therapy|
5818198|NCT00004234|Procedure|management of therapy complications|
5818199|NCT00004234|Radiation|radiation therapy|
5818200|NCT00004231|Biological|aldesleukin|
5818201|NCT00004231|Biological|filgrastim|
5818202|NCT00004231|Biological|recombinant interferon alfa|
5818203|NCT00004231|Drug|busulfan|
5818204|NCT00004231|Drug|cyclophosphamide|
5818205|NCT00004231|Drug|cytarabine|
5818206|NCT00004231|Drug|doxorubicin hydrochloride|
5818207|NCT00004231|Drug|leucovorin calcium|
5818208|NCT00004231|Drug|methotrexate|
5818209|NCT00004231|Drug|prednisone|
5818210|NCT00004231|Drug|teniposide|
5818211|NCT00004231|Drug|vincristine sulfate|
5818212|NCT00004231|Procedure|allogeneic bone marrow transplantation|
5818213|NCT00004231|Procedure|autologous bone marrow transplantation|
5818214|NCT00004231|Procedure|peripheral blood stem cell transplantation|
5818215|NCT00004228|Drug|asparaginase|Given IV
5818216|NCT00004228|Drug|cyclophosphamide|Given IV
5818217|NCT00004228|Drug|cytarabine|Given IV
5818218|NCT00004228|Drug|daunorubicin hydrochloride|Given IV
5818219|NCT00004228|Drug|dexamethasone|Given IV
5818220|NCT00004228|Drug|doxorubicin hydrochloride|Given IV
5818221|NCT00004228|Drug|leucovorin calcium|Given IV
5818222|NCT00004228|Drug|mercaptopurine|Given IV
5818223|NCT00004228|Drug|methotrexate|Given IV
5818224|NCT00004228|Drug|prednisone|Given IV
5818225|NCT00004228|Drug|thioguanine|Given PO
5818226|NCT00004228|Drug|vincristine sulfate|Given IV
5818227|NCT00004228|Radiation|radiation therapy|
5818228|NCT00004227|Biological|cetuximab|
5818229|NCT00004227|Procedure|conventional surgery|
5818230|NCT00004227|Radiation|radiation therapy|
5818231|NCT00004226|Radiation|radiation therapy|
5818232|NCT00004225|Biological|Ad5CMV-p53 gene|
5818233|NCT00004225|Radiation|radiation therapy|
5818234|NCT00004224|Drug|cyclophosphamide|
5818235|NCT00004224|Drug|etoposide|
5818236|NCT00004224|Drug|vincristine sulfate|
5818237|NCT00004224|Procedure|adjuvant therapy|
5818238|NCT00004224|Procedure|conventional surgery|
5818239|NCT00004224|Radiation|radiation therapy|
5818240|NCT00004218|Drug|chlorambucil|
5818241|NCT00004218|Drug|cyclophosphamide|
5818242|NCT00004218|Drug|doxorubicin hydrochloride|
5818243|NCT00004218|Drug|fludarabine phosphate|
5818244|NCT00004218|Drug|prednisolone|
5818245|NCT00004218|Drug|vincristine sulfate|
5818246|NCT00004212|Biological|filgrastim|
5818247|NCT00004212|Drug|exatecan mesylate|
5818248|NCT00004210|Other|loss of heterozygosity analysis|
5818249|NCT00004210|Other|microsatellite instability analysis|
5818250|NCT00004210|Other|mutation analysis|
5818251|NCT00004210|Other|counseling intervention|
5818252|NCT00004208|Drug|ATG + CSA|Mérieux; horse antithymocyte globulin (ATG) + Cyclosporine A (CSA)
5818253|NCT00004208|Behavioral|Supportive care|Patients randomized to this arm will be treated as outpatients.
5818254|NCT00004205|Drug|letrozole|Letrozole 2.5 mg daily oral administration.
5818255|NCT00004205|Drug|tamoxifen citrate|Tamoxifen 20 mg daily oral administration.
5818256|NCT00004196|Biological|recombinant interferon alfa|
5818257|NCT00004196|Procedure|lymphangiography|
5818258|NCT00004196|Drug|Observation|
5818259|NCT00004189|Biological|filgrastim|
5818260|NCT00004189|Drug|becatecarin|
5818261|NCT00004189|Drug|cisplatin|
5818262|NCT00004188|Biological|filgrastim|Given IV
5818263|NCT00004188|Drug|carboplatin|Given IV
5818264|NCT00004188|Drug|cisplatin|Given IV
5818265|NCT00004188|Drug|cyclophosphamide|Given IV
5818266|NCT00004188|Drug|doxorubicin hydrochloride|Given IV
5818267|NCT00004188|Drug|etoposide|Given IV
5818268|NCT00004188|Drug|isotretinoin|Given IV
5818269|NCT00004188|Drug|melphalan|Given IV
5818270|NCT00004188|Drug|topotecan hydrochloride|Given IV
5818271|NCT00004188|Drug|vincristine sulfate|Given IV
5818272|NCT00004188|Procedure|autologous bone marrow transplantation|
5818273|NCT00004188|Procedure|bone marrow ablation with stem cell support|
5818274|NCT00004188|Procedure|conventional surgery|All patients undergo delayed surgical resection of the residual tumor after course 5 of induction chemotherapy
5818275|NCT00004188|Procedure|peripheral blood stem cell transplantation|
5818276|NCT00004188|Radiation|radiation therapy|After completion of consolidation (at least 28 days from stem cell infusion), all patients receive local radiotherapy daily over 7 days
5818277|NCT00004181|Drug|busulfan|
5818278|NCT00004181|Drug|cyclophosphamide|
5818279|NCT00004181|Procedure|allogeneic bone marrow transplantation|
5818280|NCT00004181|Radiation|radiation therapy|
5818281|NCT00004179|Biological|rituximab|
5818282|NCT00004179|Drug|CHOP regimen|
5818283|NCT00004179|Drug|cyclophosphamide|
5818284|NCT00004179|Drug|doxorubicin hydrochloride|
5818285|NCT00004179|Drug|prednisone|
5818286|NCT00004179|Drug|vincristine sulfate|
5818287|NCT00004173|Drug|oxaliplatin|
5818288|NCT00004173|Drug|paclitaxel|
5818289|NCT00004165|Biological|filgrastim|
5818290|NCT00004165|Drug|melphalan|
5818291|NCT00004165|Procedure|peripheral blood stem cell transplantation|
5818292|NCT00004154|Drug|Fenretinide|200 mg/day (two 100 mg capsules) for 25 days of 28 day cycle.
5818293|NCT00004154|Other|Placebo|Two placebo capsules for 25 days of 28 day cycle.
5818294|NCT00004153|Genetic|reverse transcriptase-polymerase chain reaction|
5818295|NCT00004153|Procedure|sentinel lymph node biopsy|
5818296|NCT00004150|Drug|fluorouracil|
5818297|NCT00004150|Drug|leucovorin calcium|
5818298|NCT00004150|Procedure|adjuvant therapy|
5818299|NCT00004149|Drug|arsenic trioxide|
5818300|NCT00004147|Drug|incyclinide|
5818301|NCT00004144|Drug|bryostatin 1|
5818302|NCT00004144|Drug|gemcitabine hydrochloride|
5818303|NCT00004143|Drug|Campath, Chemo and/or TBI Allo SCT|Allogeneic PBSC/marrow will be collected/harvested from the donor after granulocyte colony-stimulating factor (G-CSF) priming. The allogeneic PBSCs will be infused as per current institutional practice.
5818304|NCT00004141|Drug|Cisplatin|
5818305|NCT00004141|Drug|dacarbazine|
5818306|NCT00004141|Drug|Granulocyte-macrophage colony-stimulating factor|
5818307|NCT00004138|Procedure|positron emission tomography|
5818308|NCT00004138|Procedure|radionuclide imaging|
5818309|NCT00004138|Radiation|fludeoxyglucose F 18|
5818310|NCT00004135|Biological|filgrastim|
5818311|NCT00004135|Biological|therapeutic allogeneic lymphocytes|
5818312|NCT00004135|Drug|cyclophosphamide|
5818313|NCT00004135|Drug|fludarabine phosphate|
5818314|NCT00004135|Procedure|peripheral blood stem cell transplantation|
5818315|NCT00004129|Radiation|brachytherapy|
5818316|NCT00004129|Radiation|phosphorus P32|
5818317|NCT00004128|Biological|aldesleukin|
5818318|NCT00004128|Biological|filgrastim|
5818319|NCT00004128|Drug|busulfan|
5818320|NCT00004128|Drug|cyclophosphamide|
5818321|NCT00004128|Drug|cytarabine|
5818322|NCT00004128|Drug|daunorubicin hydrochloride|
5818323|NCT00004128|Drug|etoposide|
5818324|NCT00004128|Procedure|autologous bone marrow transplantation|
5818325|NCT00004128|Procedure|peripheral blood stem cell transplantation|
5818326|NCT00004128|Radiation|radiation therapy|
5818327|NCT00004124|Drug|bicalutamide|
5818328|NCT00004124|Drug|goserelin|
5818329|NCT00004124|Drug|mitoxantrone hydrochloride|
5818330|NCT00004124|Drug|prednisone|
5818331|NCT00004115|Radiation|yttrium Y 90 monoclonal antibody HMFG1|
5818332|NCT00004110|Biological|monoclonal antibody 3F8|
5818333|NCT00004110|Drug|etoposide|
5818334|NCT00004110|Drug|isotretinoin|
5818335|NCT00004106|Drug|temozolomide|Temozolomid will be administered orally at a dose of 150mg/m2/day for 5 days for a total of 4 weeks
5818336|NCT00004103|Drug|cisplatin|
5818337|NCT00004103|Drug|floxuridine|
5818338|NCT00004103|Drug|irinotecan hydrochloride|
5818339|NCT00004103|Procedure|adjuvant therapy|
5818340|NCT00004103|Procedure|conventional surgery|
5818341|NCT00004103|Procedure|neoadjuvant therapy|
5818342|NCT00004099|Drug|cisplatin|
5818343|NCT00004099|Drug|fluorouracil|
5818344|NCT00004099|Drug|leucovorin calcium|
5818345|NCT00004099|Procedure|neoadjuvant therapy|
5818346|NCT00004092|Biological|filgrastim|Given IV or subcutaneously
5818347|NCT00004092|Drug|carboplatin|Given IV
5818348|NCT00004092|Drug|cyclophosphamide|Given IV
5818349|NCT00004092|Drug|doxorubicin hydrochloride|Given IV
5818350|NCT00004092|Drug|paclitaxel|Given IV
5818351|NCT00004092|Drug|thiotepa|Given IV
5818352|NCT00004092|Procedure|peripheral blood stem cell transplantation|Patients receive autologous peripheral blood stem cells
5818353|NCT00004088|Biological|filgrastim|
5818354|NCT00004088|Biological|recombinant interferon alfa|
5818355|NCT00004088|Drug|busulfan|
5818356|NCT00004088|Drug|cyclophosphamide|
5818357|NCT00004088|Drug|melphalan|
5818358|NCT00004088|Drug|pamidronate disodium|
5818359|NCT00004088|Drug|thalidomide|
5818360|NCT00004088|Procedure|peripheral blood stem cell transplantation|
5818361|NCT00004081|Drug|docetaxel|
5818362|NCT00004077|Drug|cisplatin|
5818363|NCT00004077|Drug|ifosfamide|
5818364|NCT00004077|Drug|paclitaxel|
5818365|NCT00004075|Drug|tanespimycin|
5818366|NCT00004072|Drug|O6-benzylguanine|Patients receive O6-benzylguanine IV over 60 minutes. Courses repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. Patients receive 2 additional courses beyond attainment of best response.
5818367|NCT00004072|Drug|carmustine|Followed 1 hour later by carmustine IV over 60 minutes. Courses repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. Patients receive 2 additional courses beyond attainment of best response.
5818368|NCT00004067|Biological|herceptin|4 mg/kg loading dose then 2 mg/kg weekly for 1 year.
5818369|NCT00004067|Drug|adriamycin|60 mg/m2 IV push every 21 days for 4 cycles.
5818370|NCT00004067|Drug|cyclophosphamide|600 mg/m2 IV every 21 days for 4 cycles
5818371|NCT00004067|Drug|taxol|175 mg/m2 IV every 21 days for 4 cycles
5818372|NCT00004066|Biological|filgrastim|
5818373|NCT00004066|Drug|docetaxel|
5818374|NCT00004066|Drug|gemcitabine hydrochloride|
5818375|NCT00004065|Drug|tanespimycin|
5818376|NCT00004063|Biological|recombinant interferon alfa|
5818377|NCT00004063|Drug|cisplatin|
5818378|NCT00004063|Drug|gemcitabine hydrochloride|
5818379|NCT00004063|Procedure|hyperthermia treatment|
5818380|NCT00004058|Drug|tetradecanoylphorbol acetate|
5818381|NCT00004054|Drug|bicalutamide|Administered orally at a dose of one 50mg tablet per day. Begins 8 weeks prior to radiotherapy and continues throughout radiotherapy.
5818382|NCT00004054|Drug|estramustine phosphate sodium|280 mg three times a day for 14 days and repeated every 3 weeks for 4 cycles
5818383|NCT00004054|Drug|etoposide|50 mg/m^2 in divided doses b.i.d. for 14 days and repeated every 3 weeks for 4 cycles
5818384|NCT00004054|Drug|flutamide|Administered orally at a dose of two 125 mg capsules three times a day for a total daily dose of 750 mg. Begins 8 weeks prior to radiotherapy and continues throughout radiotherapy.
5818385|NCT00004054|Drug|paclitaxel|135 mg/m^2 given as a 1-hour infusion (on day 2 of each cycle) and repeated every 3 weeks for 4 cycles
5818386|NCT00004054|Drug|Luteinizing hormone releasing hormone [LHRH] agonist|Releasing hormone agonists (such as leuprolide, goserelin, buserelin, triptorelin) will be given for 4 months
5818387|NCT00004054|Radiation|Radiation therapy|Radiation will begin 8 weeks following the initiation of hormone administration: 46.8 Gy to the regional lymphatics followed by a 23.4 Gy boost to the prostate to bring the total dose to the prostate to 70.2 Gy. Daily tumor doses will be 1.8 Gy per day, 5 days per week x 7-8 weeks.
5818388|NCT00004054|Drug|warfarin|To keep international normalized ratio (INR) > 1.5 and < 2.5; begins with the start of chemotherapy and will be given continuously until 4 weeks after the end of the fourth cycle of chemotherapy
5818389|NCT00004031|Biological|rituximab|375 mg/m2 IV every 21 days
5818390|NCT00004031|Drug|CHOP regimen|
5818391|NCT00004031|Drug|carmustine|
5818392|NCT00004031|Drug|cyclophosphamide|
5818393|NCT00004031|Drug|doxorubicin hydrochloride|
5818394|NCT00004031|Drug|etoposide|
5818395|NCT00004031|Drug|prednisone|
5818396|NCT00004031|Drug|vincristine sulfate|
5818397|NCT00004031|Procedure|bone marrow ablation with stem cell support|
5818398|NCT00004031|Procedure|peripheral blood stem cell transplantation|
5818399|NCT00004031|Radiation|radiation therapy|
5818400|NCT00004028|Drug|carmustine|
5818401|NCT00004028|Procedure|conventional surgery|
5818402|NCT00004024|Biological|aldesleukin|
5818403|NCT00004024|Biological|autologous tumor cell vaccine|
5818404|NCT00004024|Biological|muromonab-CD3|
5818405|NCT00004024|Biological|sargramostim|
5818406|NCT00004024|Biological|therapeutic autologous lymphocytes|
5818407|NCT00004024|Procedure|surgical procedure|
5818408|NCT00004024|Radiation|radiation therapy|
5818409|NCT00004017|Procedure|conventional surgery|
5818410|NCT00004017|Radiation|iodine I 131 monoclonal antibody TNT-1/B|
5818411|NCT00004015|Drug|sodium borocaptate|
5818412|NCT00004015|Procedure|adjuvant therapy|
5818413|NCT00004011|Drug|carboplatin|
5818414|NCT00004011|Drug|paclitaxel|
5818415|NCT00004011|Procedure|conventional surgery|
5818416|NCT00004005|Drug|fluorouracil|
5818417|NCT00004005|Drug|irinotecan hydrochloride|
5818418|NCT00004005|Drug|leucovorin calcium|
5818419|NCT00004005|Procedure|conventional surgery|
5818420|NCT00004005|Radiation|radiation therapy|
5818421|NCT00004001|Drug|docetaxel|
5818422|NCT00004001|Drug|estramustine|
5818423|NCT00004001|Drug|mitoxantrone|
5818424|NCT00004001|Drug|prednisone|
5818425|NCT00003994|Procedure|therapeutic conventional surgery|Undergo surgical resection
5818426|NCT00003994|Drug|cisplatin|Given IV
5818427|NCT00003994|Drug|vincristine sulfate|Given IV
5818428|NCT00003994|Drug|fluorouracil|Given IV
5818429|NCT00003994|Drug|amifostine trihydrate|Given IV
5818430|NCT00003994|Drug|carboplatin|Given IV
5818431|NCT00003993|Biological|aldesleukin|
5818432|NCT00003993|Drug|bryostatin 1|
5818433|NCT00003981|Drug|indisulam|
5818434|NCT00003979|Drug|CHS 828|
5818435|NCT00003977|Biological|human papillomavirus 16 E7 peptide|
5818436|NCT00003977|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5818437|NCT00003970|Drug|irinotecan hydrochloride|Given IV
5818438|NCT00003969|Drug|tanespimycin|
5818439|NCT00003966|Drug|defibrotide|
5818440|NCT00003963|Biological|rituximab|Week 1-4: Rituxan is given at 375 mg/m2 weekly x4. Week 5-8: Rituxan given every 2 weeks. Week 9-12: Schedule same as week 5-8.
5818441|NCT00003963|Drug|vinorelbine ditartrate|"Week 1-4: Vinorelbine (25mg/m2) given 1 week after the first rituxan dose and immediately after the second rituxan dose.~Week 5-8: Vinorelbine given weekly x3, with one week off. Week 9-12: Schedule same as week 5-8. Week 13 and following: If subject doesn't have disease progression, they may continue on Vinorelbine until progression or until clinically indicated."
5818442|NCT00003961|Biological|sargramostim|
5818443|NCT00003958|Biological|dactinomycin|Given IV
5818444|NCT00003958|Drug|vincristine sulfate|Given IV
5818445|NCT00003958|Drug|cyclophosphamide|Given IV
5818446|NCT00003958|Procedure|therapeutic conventional surgery|Undergo surgery
5818447|NCT00003958|Radiation|radiation therapy|Undergo radiotherapy
5818448|NCT00003958|Drug|topotecan hydrochloride|Given IV
5818449|NCT00003958|Biological|filgrastim|Given SC
5818450|NCT00003958|Biological|sargramostim|Given SC
5818451|NCT00003958|Other|laboratory biomarker analysis|Correlative studies
5818452|NCT00003955|Biological|dactinomycin|
5818453|NCT00003955|Biological|filgrastim|
5818454|NCT00003955|Biological|pegfilgrastim|
5818455|NCT00003955|Biological|sargramostim|
5818456|NCT00003955|Drug|cyclophosphamide|
5818457|NCT00003955|Drug|irinotecan hydrochloride|
5818458|NCT00003955|Drug|vincristine sulfate|
5818459|NCT00003955|Radiation|radiation therapy|
5818460|NCT00003945|Drug|cisplatin|
5818461|NCT00003945|Drug|topotecan hydrochloride|
5818462|NCT00003941|Biological|bleomycin sulfate|
5818463|NCT00003941|Biological|filgrastim|
5818464|NCT00003941|Drug|cisplatin|
5818465|NCT00003941|Drug|etoposide|
5818466|NCT00003941|Drug|ifosfamide|
5818467|NCT00003941|Procedure|bone marrow ablation with stem cell support|
5818468|NCT00003941|Procedure|peripheral blood stem cell transplantation|
5818469|NCT00003938|Drug|liposomal amphotericin B|
5818470|NCT00003934|Drug|tretinoin|Given orally
5818471|NCT00003934|Drug|daunorubicin hydrochloride|Given IV
5818472|NCT00003934|Drug|cytarabine|Given IV
5818473|NCT00003934|Drug|mercaptopurine|Given IV
5818474|NCT00003934|Drug|methotrexate|Given IV
5818475|NCT00003934|Drug|arsenic trioxide|Given IV
5818476|NCT00003928|Drug|cisplatin|Cisplatin IV over 60 minutes on day 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
5818477|NCT00003928|Drug|gemcitabine hydrochloride|Gemcitabine IV over 30 minutes on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
5818478|NCT00003913|Biological|anti-thymocyte globulin|
5818479|NCT00003913|Biological|filgrastim|
5818480|NCT00003913|Drug|busulfan|
5818481|NCT00003913|Drug|cyclophosphamide|
5818482|NCT00003913|Drug|methylprednisolone|
5818483|NCT00003913|Procedure|umbilical cord blood transplantation|
5818484|NCT00003913|Radiation|radiation therapy|
5818485|NCT00003912|Drug|carboplatin|
5818486|NCT00003912|Drug|cisplatin|
5818487|NCT00003912|Drug|doxorubicin hydrochloride|
5818488|NCT00003912|Procedure|conventional surgery|
5818489|NCT00003910|Drug|Cyclophosphamide|Patients not responding to MTX after 4 months received Cy orally at 100 mg daily in step two with the same prednisone schedule. In patients showing a partial response, but not a CR, the maximum period of therapy was 1 year.
5818490|NCT00003910|Drug|Methotrexate|Initial treatment consisted of MTX given orally at 10 mg/m2 in divided doses once weekly.
5818586|NCT00003800|Procedure|radionuclide imaging|
5818491|NCT00003910|Drug|Prednisone|Prednisone was given orally at 1 mg/kg per day for 30 days and then tapered off in the subsequent 24 days.
5818492|NCT00003909|Drug|motexafin gadolinium|Given IV
5818493|NCT00003909|Radiation|radiation therapy|Undergo radiation therapy
5818494|NCT00003909|Other|pharmacological study|Correlatives studies
5818495|NCT00003906|Drug|Raloxifene|60 mg/day plus placebo for 5 years
5818496|NCT00003906|Drug|Tamoxifen|20 mg/day plus placebo for 5 years
5818497|NCT00003903|Procedure|management of therapy complications|
5818498|NCT00003902|Drug|capecitabine|
5818499|NCT00003902|Drug|vinorelbine tartrate|
5818500|NCT00003901|Other|immunohistochemistry staining method|
5818501|NCT00003901|Procedure|biopsy|
5818502|NCT00003901|Procedure|surgery|
5818503|NCT00003896|Drug|cisplatin|
5818504|NCT00003896|Drug|liposomal doxorubicin|
5818505|NCT00003896|Drug|paclitaxel|
5818506|NCT00003893|Drug|CMF regimen|
5818507|NCT00003893|Drug|cyclophosphamide|
5818508|NCT00003893|Drug|doxorubicin hydrochloride|
5818509|NCT00003893|Drug|epirubicin hydrochloride|
5818510|NCT00003893|Drug|fluorouracil|
5818511|NCT00003893|Drug|methotrexate|
5818512|NCT00003893|Drug|mitomycin C|
5818513|NCT00003893|Drug|mitoxantrone hydrochloride|
5818514|NCT00003893|Procedure|adjuvant therapy|
5818515|NCT00003893|Radiation|radiation therapy|
5818516|NCT00003878|Drug|polifeprosan 20 with carmustine implant|
5818517|NCT00003878|Procedure|conventional surgery|
5818518|NCT00003875|Drug|busulfan|Given PO or IV
5818519|NCT00003875|Drug|etoposide|Given IV
5818520|NCT00003875|Biological|aldesleukin|Given SC
5818521|NCT00003875|Procedure|peripheral blood stem cell transplantation|Undergo autologous or syngeneic stem cell rescue
5818522|NCT00003869|Drug|carboxyamidotriazole|Given PO
5818523|NCT00003869|Other|placebo|Given PO
5818524|NCT00003869|Procedure|quality-of-life assessment|Ancillary studies
5818525|NCT00003869|Other|laboratory biomarker analysis|Correlative studies
5818526|NCT00003865|Drug|toremifene|
5818527|NCT00003863|Genetic|comparative genomic hybridization|
5818528|NCT00003863|Genetic|cytogenetic analysis|
5818529|NCT00003863|Genetic|fluorescence in situ hybridization|
5818530|NCT00003863|Genetic|gene rearrangement analysis|
5818531|NCT00003862|Drug|cisplatin|
5818532|NCT00003862|Drug|fluorouracil|
5818533|NCT00003862|Drug|leucovorin calcium|
5818534|NCT00003862|Drug|paclitaxel|
5818535|NCT00003862|Procedure|conventional surgery|
5818536|NCT00003862|Procedure|neoadjuvant therapy|
5818537|NCT00003862|Radiation|radiation therapy|
5818538|NCT00003861|Other|laboratory biomarker analysis|
5818539|NCT00003857|Drug|tamoxifen citrate|
5818540|NCT00003857|Procedure|adjuvant therapy|
5818541|NCT00003857|Radiation|radiation therapy|
5818542|NCT00003855|Procedure|axillary lymph node dissection|
5818543|NCT00003855|Radiation|whole breast irradiation|
5818544|NCT00003854|Other|immunohistochemistry staining method|
5818545|NCT00003854|Procedure|lymphangiography|
5818546|NCT00003854|Procedure|sentinel lymph node biopsy|
5818547|NCT00003854|Procedure|therapeutic conventional surgery|
5818548|NCT00003854|Radiation|whole breast irradiation|
5818549|NCT00003851|Biological|proteolytic enzymes|
5818550|NCT00003851|Drug|gemcitabine hydrochloride|
5818551|NCT00003851|Procedure|Gonzalez regimen|
5818552|NCT00003843|Drug|irinotecan hydrochloride|
5818553|NCT00003843|Genetic|mutation analysis|
5818554|NCT00003843|Genetic|polymorphism analysis|
5818555|NCT00003838|Other|T-cell replete PBPC allograft|Subjects will receive a non-myeloablative preparative regimen of cyclophosphamide 60mg/kg/d x 2 days, and fludarabine 25mg/m2 intravenously (IV) over 30 minutes daily x 5 days with or without ATG followed by a PBPC graft targeted to deliver >5x106 CD34+ cells /kg.
5818556|NCT00003837|Drug|nelarabine|
5818557|NCT00003833|Genetic|DNA stability analysis|
5818558|NCT00003833|Genetic|gene mapping|
5818559|NCT00003831|Procedure|conventional surgery|
5818560|NCT00003820|Drug|Rituximab|Rituximab (biosimilar is Zytux) is a chimeric monoclonal antibody against the protein CD20, which is primarily found on the surface of immune system B-cells. Rituximab destroys B-cells and is therefore used to treat diseases which are characterized by excessive numbers of B-cells, overactive B-cells, or dysfunctional B-cells. This includes many lymphomas, leukemias, transplant rejection, and autoimmune disorders.
5818561|NCT00003816|Biological|anti-thymocyte globulin|Given IV
5818562|NCT00003816|Drug|busulfan|Given IV
5818563|NCT00003816|Drug|carboplatin|Given IV
5818564|NCT00003816|Drug|cyclophosphamide|Given IV
5818565|NCT00003816|Drug|etoposide|Given IV
5818566|NCT00003816|Drug|fludarabine phosphate|Given IV
5818567|NCT00003816|Drug|melphalan|Given IV
5818568|NCT00003816|Drug|thiotepa|Given IV
5818569|NCT00003816|Radiation|total-body irradiation|Given twice daily for 3 days
5818570|NCT00003815|Biological|bleomycin sulfate|
5818571|NCT00003815|Drug|carmustine|
5818572|NCT00003815|Drug|cyclophosphamide|
5818573|NCT00003815|Drug|cytarabine|
5818574|NCT00003815|Drug|doxorubicin hydrochloride|
5818575|NCT00003815|Drug|etoposide|
5818576|NCT00003815|Drug|melphalan|
5818577|NCT00003815|Drug|prednisolone|
5818578|NCT00003815|Drug|vincristine sulfate|
5818579|NCT00003815|Procedure|autologous bone marrow transplantation|
5818580|NCT00003815|Radiation|radiation therapy|
5818581|NCT00003803|Drug|cisplatin|
5818582|NCT00003803|Drug|gemcitabine hydrochloride|
5818583|NCT00003803|Radiation|radiation therapy|
5818584|NCT00003800|Other|immunohistochemistry staining method|
5818585|NCT00003800|Other|laboratory biomarker analysis|
5818587|NCT00003799|Drug|fluorouracil|Given IV
5818588|NCT00003799|Drug|oxaliplatin|Given IV
5818589|NCT00003799|Radiation|radiation therapy|Undergo radiotherapy
5818590|NCT00003799|Drug|leucovorin calcium|Given IV
5818591|NCT00003799|Procedure|therapeutic conventional surgery|Undergo surgery
5818592|NCT00003796|Drug|irofulven|
5818593|NCT00003793|Genetic|clonality analysis|
5818594|NCT00003793|Genetic|microsatellite instability analysis|
5818595|NCT00003793|Genetic|mutation analysis|
5818596|NCT00003789|Drug|isolated limb perfusion|Undergo isolated limb perfusion
5818597|NCT00003789|Drug|melphalan|Given via limb perfusion
5818598|NCT00003789|Biological|recombinant tumor necrosis factor family protein|Given via slow injection into the arterial line
5818599|NCT00003789|Other|pharmacological study|Correlative studies
5818600|NCT00003789|Other|laboratory biomarker analysis|Correlative studies
5818601|NCT00003788|Drug|carmustine|
5818602|NCT00003788|Drug|lomustine|
5818603|NCT00003788|Drug|porfimer sodium|
5818604|NCT00003788|Drug|procarbazine hydrochloride|
5818605|NCT00003788|Procedure|neoadjuvant therapy|
5818606|NCT00003788|Procedure|surgical procedure|
5818607|NCT00003788|Radiation|radiation therapy|
5818608|NCT00003782|Drug|cyclophosphamide|Arm 1: 600 mg/m2 IV every 21 days for 4 cycles; Arm 3: 500 mg/m2 IV every 21 days for 4 cycles
5818609|NCT00003782|Drug|docetaxel|Arm 1: 100 mg/m2 IV every 21 days for 4 cycles; Arms 2 and 3: 75 mg/m2 IV every 21 days for 4 cycles
5818610|NCT00003782|Drug|doxorubicin|Arm 1: 60 mg/m2 IV every 21 days for 4 cycles; Arms 2 and 3: 50 mg/m2 IV every 21 days for 4 cycles
5818611|NCT00003771|Biological|therapeutic estradiol|
5818612|NCT00003771|Drug|norethindrone acetate|
5818613|NCT00003764|Drug|cyclophosphamide|
5818614|NCT00003764|Drug|fludarabine phosphate|
5818615|NCT00003753|Drug|dexamethasone|
5818616|NCT00003753|Drug|floxuridine|
5818617|NCT00003753|Drug|irinotecan hydrochloride|
5818618|NCT00003753|Procedure|adjuvant therapy|
5818619|NCT00003753|Procedure|conventional surgery|
5818620|NCT00003750|Biological|hu14.18-IL2 fusion protein|
5818621|NCT00003749|Procedure|adjuvant therapy|
5818622|NCT00003749|Procedure|conventional surgery|
5818623|NCT00003749|Radiation|brachytherapy|
5818624|NCT00003749|Radiation|radiation therapy|
5818625|NCT00003746|Drug|2-chlorodeoxyadenosine (CDA) daily|Daily administration
5818626|NCT00003746|Drug|2-chlorodeoxyadenosine weekly|Weekly administration
5818627|NCT00003745|Drug|topotecan hydrochloride|
5818628|NCT00003744|Drug|gemcitabine|
5818629|NCT00003741|Biological|monoclonal antibody HeFi-1|
5818630|NCT00003739|Biological|filgrastim|
5818631|NCT00003737|Drug|becatecarin|
5818632|NCT00003732|Drug|carboplatin|
5818633|NCT00003732|Drug|paclitaxel|
5818634|NCT00003732|Drug|topotecan hydrochloride|
5818635|NCT00003730|Drug|fluorouracil|
5818636|NCT00003730|Drug|vinorelbine tartrate|
5818637|NCT00003728|Drug|asparaginase|
5818638|NCT00003728|Drug|cyclophosphamide|
5818639|NCT00003728|Drug|cytarabine|
5818640|NCT00003728|Drug|daunorubicin hydrochloride|
5818641|NCT00003728|Drug|dexamethasone|
5818642|NCT00003728|Drug|doxorubicin hydrochloride|
5818643|NCT00003728|Drug|etoposide|
5818644|NCT00003728|Drug|leucovorin calcium|
5818645|NCT00003728|Drug|mercaptopurine|
5818646|NCT00003728|Drug|methotrexate|
5818647|NCT00003728|Drug|methylprednisolone|
5818648|NCT00003728|Drug|mitoxantrone hydrochloride|
5818649|NCT00003728|Drug|prednisolone|
5818650|NCT00003728|Drug|therapeutic hydrocortisone|
5818651|NCT00003728|Drug|thioguanine|
5818652|NCT00003728|Drug|vincristine sulfate|
5818653|NCT00003728|Drug|vindesine|
5818654|NCT00003728|Procedure|allogeneic bone marrow transplantation|
5818655|NCT00003728|Procedure|peripheral blood stem cell transplantation|
5818656|NCT00003727|Biological|filgrastim|
5818657|NCT00003727|Biological|recombinant interferon alfa|
5818658|NCT00003727|Biological|sargramostim|
5818659|NCT00003727|Biological|therapeutic autologous lymphocytes|
5818660|NCT00003727|Drug|carmustine|
5818661|NCT00003727|Drug|cyclophosphamide|
5818662|NCT00003727|Drug|etoposide|
5818663|NCT00003727|Drug|gemcitabine hydrochloride|
5818664|NCT00003727|Drug|melphalan|
5818665|NCT00003727|Procedure|bone marrow ablation with stem cell support|
5818666|NCT00003727|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5818667|NCT00003702|Biological|Dactinomycin|Given IV
5818668|NCT00003702|Drug|Methotrexate|Given intramuscularly
5818669|NCT00003696|Drug|carboplatin|
5818670|NCT00003696|Drug|cyclophosphamide|
5818671|NCT00003696|Drug|doxorubicin hydrochloride|
5818672|NCT00003696|Drug|etoposide|
5818673|NCT00003696|Drug|paclitaxel|
5818674|NCT00003690|Drug|alvocidib|
5818675|NCT00003690|Drug|carboplatin|
5818676|NCT00003690|Drug|cisplatin|
5818677|NCT00003688|Biological|dactinomycin|
5818678|NCT00003687|Drug|dextromethorphan hydrobromide|
5818679|NCT00003687|Drug|morphine sulfate|
5818680|NCT00003678|Drug|tamoxifen citrate|
5818681|NCT00003678|Procedure|adjuvant therapy|
5818682|NCT00003659|Biological|filgrastim|Filgrastim (300 μg for patients ≤ 70 kg or 480 μg for patients > 70 kg) will be administered beginning two days after each cyclophosphamide dose and given for a total of eight subcutaneous daily doses.
5818683|NCT00003659|Biological|rituximab|Approximately four weeks after the completion of the last cyclophosphamide dose, patients will receive rituximab 375mg/m2 as an intravenous infusion once weekly for four doses.
5818711|NCT00003650|Drug|methylprednisolone|
5818684|NCT00003659|Drug|cyclophosphamide|Cyclophosphamide 3000mg/m2 will be given intravenously q 2 - 3 weeks x 3 doses.
5818685|NCT00003659|Drug|fludarabine phosphate|Fludarabine will be administered intravenously at a dose of 25 mg/m2 per day x 5 days every 4 weeks.
5818686|NCT00003658|Biological|filgrastim|
5818687|NCT00003658|Biological|rituximab|
5818688|NCT00003658|Drug|cyclophosphamide|
5818689|NCT00003658|Drug|pentostatin|
5818690|NCT00003656|Biological|recombinant interferon alfa|
5818691|NCT00003656|Drug|tretinoin liposome|
5818692|NCT00003653|Drug|bicalutamide|"Patients on the IAS arm should receive a minimum of 4 weeks of antiandrogen and a total of 8 months of LHRH analog during each on-treatment interval. The dose and frequency of LHRH treatment will be determined by the drug being administered (Appendix IX). Patients on the IAS arm should not be given an LHRH analog injection at the end of month 8 unless the patient is transferred to continuous treatment as per protocol upon completion of the 8 month intermittent treatment.~Patients may be treated with any commercially available LHRH analog and antiandrogen during or after protocol treatment (Appendix IX). Patients may switch drugs at any time during or after protocol treatment. The dose and schedule of treatment will depend on the agent used. Patients should continue to receive hormone therapy without interruption until hormone resistance has been documented"
5818693|NCT00003653|Drug|buserelin|"Patients on the IAS arm should receive a minimum of 4 weeks of antiandrogen and a total of 8 months of LHRH analog during each on-treatment interval. The dose and frequency of LHRH treatment will be determined by the drug being administered (Appendix IX). Patients on the IAS arm should not be given an LHRH analog injection at the end of month 8 unless the patient is transferred to continuous treatment as per protocol upon completion of the 8 month intermittent treatment.~Patients may be treated with any commercially available LHRH analog and antiandrogen during or after protocol treatment (Appendix IX). Patients may switch drugs at any time during or after protocol treatment. The dose and schedule of treatment will depend on the agent used. Patients should continue to receive hormone therapy without interruption until hormone resistance has been documented"
5818694|NCT00003653|Drug|cyproterone acetate|"Patients on the IAS arm should receive a minimum of 4 weeks of antiandrogen and a total of 8 months of LHRH analog during each on-treatment interval. The dose and frequency of LHRH treatment will be determined by the drug being administered (Appendix IX). Patients on the IAS arm should not be given an LHRH analog injection at the end of month 8 unless the patient is transferred to continuous treatment as per protocol upon completion of the 8 month intermittent treatment.~Patients may be treated with any commercially available LHRH analog and antiandrogen during or after protocol treatment (Appendix IX). Patients may switch drugs at any time during or after protocol treatment. The dose and schedule of treatment will depend on the agent used. Patients should continue to receive hormone therapy without interruption until hormone resistance has been documented"
5818695|NCT00003653|Drug|flutamide|"Patients on the IAS arm should receive a minimum of 4 weeks of antiandrogen and a total of 8 months of LHRH analog during each on-treatment interval. The dose and frequency of LHRH treatment will be determined by the drug being administered (Appendix IX). Patients on the IAS arm should not be given an LHRH analog injection at the end of month 8 unless the patient is transferred to continuous treatment as per protocol upon completion of the 8 month intermittent treatment.~Patients may be treated with any commercially available LHRH analog and antiandrogen during or after protocol treatment (Appendix IX). Patients may switch drugs at any time during or after protocol treatment. The dose and schedule of treatment will depend on the agent used. Patients should continue to receive hormone therapy without interruption until hormone resistance has been documented"
5818696|NCT00003653|Drug|goserelin|"Patients on the IAS arm should receive a minimum of 4 weeks of antiandrogen and a total of 8 months of LHRH analog during each on-treatment interval. The dose and frequency of LHRH treatment will be determined by the drug being administered (Appendix IX). Patients on the IAS arm should not be given an LHRH analog injection at the end of month 8 unless the patient is transferred to continuous treatment as per protocol upon completion of the 8 month intermittent treatment.~Patients may be treated with any commercially available LHRH analog and antiandrogen during or after protocol treatment (Appendix IX). Patients may switch drugs at any time during or after protocol treatment. The dose and schedule of treatment will depend on the agent used. Patients should continue to receive hormone therapy without interruption until hormone resistance has been documented"
5818697|NCT00003653|Drug|leuprolide acetate|"Patients on the IAS arm should receive a minimum of 4 weeks of antiandrogen and a total of 8 months of LHRH analog during each on-treatment interval. The dose and frequency of LHRH treatment will be determined by the drug being administered (Appendix IX). Patients on the IAS arm should not be given an LHRH analog injection at the end of month 8 unless the patient is transferred to continuous treatment as per protocol upon completion of the 8 month intermittent treatment.~Patients may be treated with any commercially available LHRH analog and antiandrogen during or after protocol treatment (Appendix IX). Patients may switch drugs at any time during or after protocol treatment. The dose and schedule of treatment will depend on the agent used. Patients should continue to receive hormone therapy without interruption until hormone resistance has been documented"
5818698|NCT00003653|Drug|nilutamide|"Patients on the IAS arm should receive a minimum of 4 weeks of antiandrogen and a total of 8 months of LHRH analog during each on-treatment interval. The dose and frequency of LHRH treatment will be determined by the drug being administered (Appendix IX). Patients on the IAS arm should not be given an LHRH analog injection at the end of month 8 unless the patient is transferred to continuous treatment as per protocol upon completion of the 8 month intermittent treatment.~Patients may be treated with any commercially available LHRH analog and antiandrogen during or after protocol treatment (Appendix IX). Patients may switch drugs at any time during or after protocol treatment. The dose and schedule of treatment will depend on the agent used. Patients should continue to receive hormone therapy without interruption until hormone resistance has been documented"
5818699|NCT00003652|Drug|cisplatin|
5818700|NCT00003652|Drug|fluorouracil|
5818701|NCT00003652|Procedure|neoadjuvant therapy|
5818702|NCT00003652|Radiation|radiation therapy|
5818703|NCT00003650|Drug|asparaginase|
5818704|NCT00003650|Drug|cyclophosphamide|
5818705|NCT00003650|Drug|cytarabine|
5818706|NCT00003650|Drug|daunorubicin hydrochloride|
5818707|NCT00003650|Drug|dexamethasone|
5818708|NCT00003650|Drug|etoposide|
5818709|NCT00003650|Drug|mercaptopurine|
5818710|NCT00003650|Drug|methotrexate|
5818712|NCT00003650|Drug|mitoxantrone hydrochloride|
5818713|NCT00003650|Drug|prednisone|
5818714|NCT00003650|Drug|vincristine sulfate|
5818715|NCT00003650|Radiation|radiation therapy|
5818716|NCT00003644|Drug|carboplatin|
5818717|NCT00003644|Drug|paclitaxel|
5818718|NCT00003643|Biological|bleomycin sulfate|
5818719|NCT00003643|Biological|filgrastim|
5818720|NCT00003643|Drug|cisplatin|
5818721|NCT00003643|Drug|etoposide|
5818722|NCT00003643|Drug|paclitaxel|
5818723|NCT00003641|Biological|interferon alfa-2b|Given IV
5818724|NCT00003641|Other|observation|Patients undergo observation for 4 weeks.
5818725|NCT00003637|Drug|cisplatin|
5818726|NCT00003637|Drug|fluorouracil|
5818727|NCT00003637|Radiation|radiation therapy|
5818728|NCT00003636|Drug|carboplatin|
5818729|NCT00003636|Drug|cisplatin|
5818730|NCT00003636|Procedure|conventional surgery|
5818731|NCT00003636|Procedure|neoadjuvant therapy|
5818732|NCT00003633|Drug|docetaxel|
5818733|NCT00003633|Drug|estramustine phosphate sodium|
5818734|NCT00003633|Drug|mitoxantrone hydrochloride|
5818735|NCT00003633|Drug|prednisone|
5818736|NCT00003631|Biological|filgrastim|
5818737|NCT00003631|Drug|carboplatin|
5818738|NCT00003631|Drug|carmustine|
5818739|NCT00003631|Drug|cyclophosphamide|
5818740|NCT00003631|Drug|cytarabine|
5818741|NCT00003631|Drug|etoposide|
5818742|NCT00003631|Drug|ifosfamide|
5818743|NCT00003631|Drug|melphalan|
5818744|NCT00003631|Procedure|bone marrow ablation with stem cell support|
5818745|NCT00003631|Procedure|peripheral blood stem cell transplantation|
5818746|NCT00003631|Radiation|radiation therapy|
5818747|NCT00003613|Drug|O6-benzylguanine|Given IV
5818748|NCT00003613|Drug|carmustine|Given topically
5818749|NCT00003613|Other|laboratory biomarker analysis|Correlative studies
5818750|NCT00003612|Biological|trastuzumab|
5818751|NCT00003612|Drug|carboplatin|
5818752|NCT00003612|Drug|paclitaxel|
5818753|NCT00003611|Drug|acitretin|
5818754|NCT00003611|Other|placebo|
5818755|NCT00003607|Radiation|radiation therapy|
5818756|NCT00003603|Drug|cyclophosphamide|
5818757|NCT00003603|Drug|dexamethasone|
5818758|NCT00003603|Drug|idarubicin|
5818759|NCT00003603|Drug|lomustine|
5818760|NCT00003603|Drug|melphalan|
5818761|NCT00003603|Drug|prednisolone|
5818762|NCT00003602|Drug|cytarabine|
5818763|NCT00003602|Drug|etoposide|
5818764|NCT00003602|Drug|idarubicin|
5818765|NCT00003602|Drug|mitoxantrone hydrochloride|
5818766|NCT00003596|Drug|cisplatin|
5818767|NCT00003596|Drug|fluorouracil|
5818768|NCT00003596|Drug|mitomycin C|
5818769|NCT00003596|Radiation|radiation therapy|
5818770|NCT00003593|Drug|asparaginase|Given IV
5818771|NCT00003593|Drug|cytarabine|Given IT
5818772|NCT00003593|Drug|daunorubicin hydrochloride|Given IV
5818773|NCT00003593|Drug|methotrexate|Given IV
5818774|NCT00003593|Drug|therapeutic hydrocortisone|Given IT
5818775|NCT00003593|Drug|thioguanine|Given IV
5818776|NCT00003590|Drug|hydroxyurea|20 mg/kg/day PO
5818777|NCT00003577|Drug|CMF regimen|
5818778|NCT00003577|Drug|cyclophosphamide|
5818779|NCT00003577|Drug|epirubicin hydrochloride|
5818780|NCT00003577|Drug|fluorouracil|
5818781|NCT00003577|Drug|methotrexate|
5818782|NCT00003577|Procedure|adjuvant therapy|
5818783|NCT00003577|Radiation|radiation therapy|
5818784|NCT00003576|Drug|cisplatin|
5818785|NCT00003576|Drug|fluorouracil|
5818786|NCT00003576|Procedure|surgical procedure|
5818787|NCT00003576|Radiation|radiation therapy|
5818788|NCT00003569|Drug|cisplatin|
5818789|NCT00003569|Drug|dimesna|
5818790|NCT00003569|Drug|paclitaxel|
5818791|NCT00003568|Biological|aldesleukin|
5818792|NCT00003568|Biological|gp100 antigen|
5818793|NCT00003568|Biological|incomplete Freund's adjuvant|
5818794|NCT00003567|Biological|filgrastim|Patients receive filgrastim (G-CSF) subcutaneously (SC) once daily on days 1-5 (or G-CSF twice daily alone for 4-5 days).
5818795|NCT00003567|Biological|sargramostim|Patients receive sargramostim (GM-CSF) subcutaneously (SC) once daily on days 1-5 (or G-CSF twice daily alone for 4-5 days).
5818796|NCT00003567|Biological|therapeutic autologous lymphocytes|
5818797|NCT00003567|Drug|O6-benzylguanine|Patients receive O6-benzylguanine (BG) IV over 1 hour every 6 weeks for 5 courses. Four weeks after the completion of BG and carmustine, patients receive BG IV over 1 hour every 4 weeks for up to 5 courses, in the absence of hematologic toxicity. Patients with responding disease may continue to receive BG and temzolomide in the absence of disease progression or unacceptable toxicity.
5818798|NCT00003567|Drug|carmustine|Patients receive carmustine IV over 1 hour every 6 weeks for 5 courses.Cohorts of 3-6 patients receive escalating numbers of CD34 stem cells targeted for retroviral infection and escalating doses of carmustine.
5818799|NCT00003567|Drug|temozolomide|Four weeks after the completion of BG and carmustine, patients receive temozolomide IV over 1 hour every 4 weeks for up to 5 courses, in the absence of hematologic toxicity. Patients with responding disease may continue to receive BG and temzolomide in the absence of disease progression or unacceptable toxicity.
5818800|NCT00003567|Procedure|in vitro-treated peripheral blood stem cell transplantation|Approximately 72 hours after the end of the first course of chemotherapy, patients receive reinfusion of retrovirally-transduced hematopoietic stem cells over 5-10 minutes. Cohorts of 3-6 patients receive escalating numbers of CD34 stem cells targeted for retroviral infection and escalating doses of carmustine.
5818801|NCT00003566|Procedure|videothoracoscopy|
5818802|NCT00003565|Drug|docetaxel|
5818803|NCT00003560|Drug|carboplatin|
5818804|NCT00003560|Drug|docetaxel|
5818805|NCT00003558|Drug|carboplatin|
5818810|NCT00003553|Biological|anti-thymocyte globulin|Given IV
5818811|NCT00003553|Drug|cyclophosphamide|Given IV
5818812|NCT00003553|Drug|cyclosporine|Given IV
5818813|NCT00003553|Drug|fludarabine phosphate|Given IV
5818814|NCT00003553|Drug|methotrexate|Given as GVHD prophylaxis
5818815|NCT00003553|Drug|mycophenolate mofetil|Given as GVHD prophylaxis
5818816|NCT00003538|Biological|graft versus host disease prophylaxis/therapy|
5818817|NCT00003538|Procedure|allogeneic bone marrow transplantation|
5818818|NCT00003537|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Adults with an anaplastic astrocytoma will receive Antineoplaston therapy (Atengenal + Astugenal).
5818819|NCT00003536|Drug|antineoplaston A10|
5818820|NCT00003536|Drug|methotrexate|
5818821|NCT00003536|Procedure|alternative product therapy|
5818822|NCT00003536|Procedure|biological therapy|
5818823|NCT00003536|Procedure|biologically based therapies|
5818824|NCT00003536|Procedure|cancer prevention intervention|
5818825|NCT00003536|Procedure|chemotherapy|
5818826|NCT00003536|Procedure|complementary and alternative therapy|
5818827|NCT00003536|Procedure|differentiation therapy|
5818828|NCT00003535|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Children with a recurrent/progressive high grade glioma will receive Antineoplaston therapy (Atengenal + Astugenal).
5818829|NCT00003534|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients With Refractory Stage IV Prostate Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818830|NCT00003533|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Metastatic Pancreatic Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818831|NCT00003532|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage III or IV Ovarian Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818832|NCT00003531|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV Pancreatic Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818833|NCT00003530|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Primary Liver Cancer Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818834|NCT00003526|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Cancer of Unknown Primary Origin will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818835|NCT00003525|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV Cancer of the Cervix and/or Vulva will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818836|NCT00003524|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stomach Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818837|NCT00003522|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Cancer of the Small Intestine will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818838|NCT00003521|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Soft Tissue Sarcoma will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818839|NCT00003520|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV Kidney Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818840|NCT00003517|Drug|antineoplaston A10|
5818841|NCT00003517|Drug|antineoplaston AS2-1|
5818842|NCT00003517|Drug|bicalutamide|
5818843|NCT00003517|Drug|flutamide|
5818844|NCT00003517|Drug|leuprolide acetate|
5818845|NCT00003517|Procedure|alternative product therapy|
5818846|NCT00003517|Procedure|antiandrogen therapy|
5818847|NCT00003517|Procedure|biological therapy|
5818848|NCT00003517|Procedure|biologically based therapies|
5818849|NCT00003517|Procedure|cancer prevention intervention|
5818850|NCT00003517|Procedure|complementary and alternative therapy|
5818851|NCT00003517|Procedure|differentiation therapy|
5818852|NCT00003517|Procedure|endocrine therapy|
5818853|NCT00003517|Procedure|hormone therapy|
5818854|NCT00003516|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Antineoplaston therapy (Atengenal + Astugenal) capsules orally six to seven times a day. Treatment continues in the absence of disease progression or unacceptable toxicity. absence of disease progression or unacceptable toxicity.
5818855|NCT00003515|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients With Metastatic, Recurrent, or Refractory Primitive Neuroectodermal Tumors will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818857|NCT00003514|Drug|antineoplaston AS2-1|
5818858|NCT00003514|Procedure|alternative product therapy|
5818859|NCT00003514|Procedure|biological therapy|
5818860|NCT00003514|Procedure|biologically based therapies|
5818861|NCT00003514|Procedure|cancer prevention intervention|
5818862|NCT00003514|Procedure|complementary and alternative therapy|
5818863|NCT00003514|Procedure|differentiation therapy|
5818864|NCT00003513|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients With Metastatic, Recurrent, or Refractory Neuroblastoma will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818865|NCT00003512|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients With Recurrent or Refractory Waldenstrom's Macroglobulinemia will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818866|NCT00003511|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Multiple Myeloma will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818867|NCT00003509|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV Melanoma will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818868|NCT00003508|Drug|antineoplaston A10|
5818869|NCT00003508|Drug|antineoplaston AS2-1|
5818870|NCT00003505|Drug|antineoplaston A10|
5818871|NCT00003505|Drug|antineoplaston AS2-1|
5818872|NCT00003505|Procedure|alternative product therapy|
5818873|NCT00003505|Procedure|biological therapy|
5818874|NCT00003505|Procedure|biologically based therapies|
5818875|NCT00003505|Procedure|cancer prevention intervention|
5818876|NCT00003505|Procedure|complementary and alternative therapy|
5818877|NCT00003505|Procedure|differentiation therapy|
5818878|NCT00003502|Drug|antineoplaston A10|
5818879|NCT00003502|Drug|antineoplaston AS2-1|
5818880|NCT00003502|Procedure|alternative product therapy|
5818881|NCT00003502|Procedure|biological therapy|
5818882|NCT00003502|Procedure|biologically based therapies|
5818883|NCT00003502|Procedure|cancer prevention intervention|
5818884|NCT00003502|Procedure|complementary and alternative therapy|
5818885|NCT00003502|Procedure|differentiation therapy|
5818886|NCT00003501|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Refractory or Recurrent High-Grade Stage II - IV Non-Hodgkin's Lymphoma will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818887|NCT00003500|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Refractory or Recurrent Intermediate-Grade Stage II - IV Non-Hodgkin's Lymphoma will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818888|NCT00003499|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Low-grade non-Hodgkin's lymphoma will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818889|NCT00003498|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Non-Hodgkin's Lymphoma will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818890|NCT00003497|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Antineoplaston therapy (Atengenal + Astugenal) capsules orally six to seven times a day. Treatment continues in the absence of disease progression or unacceptable toxicity. absence of disease progression or unacceptable toxicity.
5818891|NCT00003496|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Recurrent or Extensive-Stage Small Cell Lung Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818892|NCT00003495|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV or Recurrent Lung Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818893|NCT00003494|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Recurrent or Stage IV Lung Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818894|NCT00003492|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV Lung Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818895|NCT00003491|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV Lung Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818896|NCT00003489|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Advanced Head and Neck Cancer Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818898|NCT00003487|Drug|antineoplaston AS2-1|
5818899|NCT00003486|Drug|antineoplaston A10|
5818900|NCT00003486|Drug|antineoplaston AS2-1|
5818901|NCT00003486|Procedure|alternative product therapy|
5818902|NCT00003486|Procedure|biological therapy|
5818903|NCT00003486|Procedure|biologically based therapies|
5818904|NCT00003486|Procedure|cancer prevention intervention|
5818905|NCT00003486|Procedure|complementary and alternative therapy|
5818906|NCT00003486|Procedure|differentiation therapy|
5818907|NCT00003485|Drug|antineoplaston A10, antineoplaston AS2-1 (ANP)|"Patients with metastatic or unresectable Colon Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818908|NCT00003483|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Adults with a meningioma will receive Antineoplaston therapy (Atengenal + Astugenal).
5818909|NCT00003479|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Patients with an ependymoma will receive Antineoplaston therapy (Atengenal + Astugenal).
5818910|NCT00003478|Procedure|conventional surgery|
5818911|NCT00003478|Radiation|iodine I 131 monoclonal antibody 81C6|
5818912|NCT00003478|Radiation|radiation therapy|
5818913|NCT00003477|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Children with a visual pathway glioma, which is not amenable to standard therapy or has not responded to standard therapy, will receive Antineoplaston therapy (Atengenal + Astugenal).
5818914|NCT00003476|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Children with a primary malignant brain tumor will receive Antineoplaston therapy (Atengenal + Astugenal).
5818915|NCT00003475|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Adults with a primary malignant brain tumor that has not responded to standard therapy will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818916|NCT00003474|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Adults with a residual/recurrent/progressive Glioblastoma Multiforme will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818917|NCT00003473|Drug|Atengenal|Adults with a recurrent or refractory mixed glioma will receive Antineoplaston therapy (Atengenal + Astugenal).
5818918|NCT00003473|Drug|Astugenal|Adults with a recurrent or refractory mixed glioma will receive Antineoplaston therapy (Atengenal + Astugenal).
5818919|NCT00003472|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Adults with a recurrent/progressive Oligodendroglioma will receive Antineoplaston therapy (Atengenal + Astugenal).
5818920|NCT00003471|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Adults with a recurrent/progressive low grade astrocytoma will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818921|NCT00003470|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Adults with an anaplastic astrocytoma that has not responded to standard therapy will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818922|NCT00003469|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Children with a Rhabdoid tumor will receive Antineoplaston therapy (Atengenal + Astugenal).
5818923|NCT00003468|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Children with a low grade astrocytoma that have not responded to standard therapy will receive Antineoplaston therapy (Atengenal + Astugenal).
5818924|NCT00003467|Drug|carmustine|
5818925|NCT00003467|Drug|polifeprosan 20 with carmustine implant|
5818926|NCT00003467|Procedure|surgical procedure|
5818927|NCT00003466|Drug|temozolomide|
5818928|NCT00003462|Drug|busulfan|
5818929|NCT00003461|Procedure|surgical procedure|
5818930|NCT00003461|Radiation|astatine At 211 monoclonal antibody 81C6|
5818931|NCT00003460|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Children with a primitive neuroectodermal tumor that has not responded to standard therapy will receive Antineoplaston therapy (Atengenal + Astugenal).
5818932|NCT00003459|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Patients with a brain stem glioma will receive Antineoplaston therapy (Atengenal + Astugenal)
5818933|NCT00003458|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Children with a brain tumor will receive Antineoplaston therapy (Atengenal + Astugenal).
5818934|NCT00003457|Drug|Antineoplaston therapy (Atengenal + Astugenal)|Adults with a persistent or recurrent brain tumor will receive Antineoplaston therapy (Atengenal + Astugenal).
5818935|NCT00003456|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Adults with a newly diagnosed Glioblastoma Multiforme will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818936|NCT00003455|Drug|antineoplaston A10|
5818937|NCT00003455|Drug|antineoplaston AS2-1|
5818938|NCT00003455|Procedure|alternative product therapy|
5818939|NCT00003455|Procedure|biological therapy|
5818940|NCT00003455|Procedure|biologically based therapies|
5818941|NCT00003455|Procedure|cancer prevention intervention|
5818942|NCT00003455|Procedure|complementary and alternative therapy|
5818943|NCT00003455|Procedure|differentiation therapy|
5818944|NCT00003454|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV Breast Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5819023|NCT00003335|Drug|busulfan|If TBI is not tolerated, busulfan is substituted and administered orally every 6 hours for 4 days on days -8 to -5.
5819024|NCT00003335|Drug|cyclosporine|Cyclosporine begin on day -2 and continue for 6 months.
5818945|NCT00003453|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV Adrenal Gland Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818946|NCT00003452|Drug|Antineoplaston therapy (Atengenal + Astugenal)|"Patients with Stage IV Bladder Cancer will receive Antineoplaston therapy (Atengenal + Astugenal).~The daily doses of A10 and AS2-1 are divided into six infusions, which are given at 4-hourly intervals. Each infusion starts with infusion of A10 and is immediately followed by infusion of AS2-1."
5818947|NCT00003440|Drug|paclitaxel|Given IV over 1 hour or 3 hours
5818948|NCT00003440|Biological|trastuzumab|Given IV
5818949|NCT00003440|Procedure|quality-of-life assessment|Ancillary studies
5818950|NCT00003440|Other|laboratory biomarker analysis|Correlative studies
5818951|NCT00003437|Drug|asparaginase|
5818952|NCT00003437|Drug|cyclophosphamide|
5818953|NCT00003437|Drug|cytarabine|
5818954|NCT00003437|Drug|daunorubicin hydrochloride|
5818955|NCT00003437|Drug|dexamethasone|
5818956|NCT00003437|Drug|doxorubicin hydrochloride|
5818957|NCT00003437|Drug|mercaptopurine|
5818958|NCT00003437|Drug|methotrexate|
5818959|NCT00003437|Drug|pegaspargase|
5818960|NCT00003437|Drug|prednisolone|
5818961|NCT00003437|Drug|thioguanine|
5818962|NCT00003437|Drug|vincristine sulfate|
5818963|NCT00003437|Radiation|radiation therapy|
5818964|NCT00003429|Procedure|biopsy|
5818965|NCT00003429|Procedure|computed tomography|
5818966|NCT00003429|Procedure|positron emission tomography|
5818967|NCT00003429|Radiation|fludeoxyglucose F 18|
5818968|NCT00003422|Drug|fluorouracil|
5818969|NCT00003422|Drug|leucovorin calcium|
5818970|NCT00003422|Procedure|adjuvant therapy|
5818971|NCT00003422|Procedure|conventional surgery|
5818972|NCT00003422|Procedure|neoadjuvant therapy|
5818973|NCT00003422|Radiation|radiation therapy|
5818974|NCT00003420|Procedure|computed tomography|
5818975|NCT00003419|Procedure|antiviral therapy|
5818976|NCT00003417|Drug|carmustine|
5818977|NCT00003417|Radiation|radiation therapy|
5818978|NCT00003404|Radiation|Adjuvant Radiotherapy|Adjuvant radiation therapy
5818979|NCT00003389|Drug|Doxorubicin|given IV
5818980|NCT00003389|Drug|Bleomycin|given IV
5818981|NCT00003389|Drug|Vinblastine|given IV
5818982|NCT00003389|Drug|Dacarbazine|given IV
5818983|NCT00003389|Drug|Vincristine|given IV
5818984|NCT00003389|Drug|Mechlorethamine|given IV
5818985|NCT00003389|Drug|Etoposide|given IV
5818986|NCT00003389|Drug|Prednisone|taken orally
5818987|NCT00003389|Drug|Cyclophosphamide|given IV
5818988|NCT00003389|Radiation|Radiotherapy|
5818989|NCT00003385|Drug|carboplatin|
5818990|NCT00003385|Drug|paclitaxel|
5818991|NCT00003385|Drug|pegylated liposomal doxorubicin hydrochloride|
5818992|NCT00003384|Other|Cervical Papanicolaou Test|Undergo Pap smear
5818993|NCT00003384|Procedure|Conization|Undergo cone biopsy
5818994|NCT00003384|Other|Laboratory Biomarker Analysis|Correlative studies
5818995|NCT00003379|Drug|cisplatin|
5818996|NCT00003379|Drug|paclitaxel|
5818997|NCT00003379|Radiation|brachytherapy|
5818998|NCT00003379|Radiation|radiation therapy|
5818999|NCT00003377|Drug|cisplatin|
5819000|NCT00003377|Drug|paclitaxel|
5819001|NCT00003377|Radiation|brachytherapy|
5819002|NCT00003377|Radiation|radiation therapy|
5819003|NCT00003375|Drug|lomustine|
5819004|NCT00003375|Drug|procarbazine hydrochloride|
5819005|NCT00003375|Drug|vincristine sulfate|
5819006|NCT00003375|Radiation|radiation therapy|
5819007|NCT00003354|Procedure|conventional surgery|
5819008|NCT00003354|Procedure|laparoscopic surgery|
5819009|NCT00003342|Biological|filgrastim|
5819010|NCT00003342|Drug|carboplatin|
5819011|NCT00003342|Drug|doxorubicin hydrochloride|
5819012|NCT00003342|Drug|gemcitabine hydrochloride|
5819013|NCT00003342|Drug|paclitaxel|
5819014|NCT00003336|Biological|anti-thymocyte globulin|The regimen varies according to the underlying cause of the anemia.Patients receive high-dose chemotherapy and/or radiotherapy as a conditioning regimen beginning 6-9 days before the umbilical cord blood transplant (UCBT).
5819015|NCT00003336|Drug|busulfan|The regimen varies according to the underlying cause of the anemia.Patients receive high-dose chemotherapy and/or radiotherapy as a conditioning regimen beginning 6-9 days before the umbilical cord blood transplant (UCBT).
5819016|NCT00003336|Drug|cyclophosphamide|The regimen varies according to the underlying cause of the anemia.Patients receive high-dose chemotherapy and/or radiotherapy as a conditioning regimen beginning 6-9 days before the umbilical cord blood transplant (UCBT).
5819017|NCT00003336|Drug|melphalan|The regimen varies according to the underlying cause of the anemia.Patients receive high-dose chemotherapy and/or radiotherapy as a conditioning regimen beginning 6-9 days before the umbilical cord blood transplant (UCBT).
5819018|NCT00003336|Drug|methylprednisolone|The regimen varies according to the underlying cause of the anemia.Patients receive high-dose chemotherapy and/or radiotherapy as a conditioning regimen beginning 6-9 days before the umbilical cord blood transplant (UCBT).
5819019|NCT00003336|Procedure|bone marrow ablation with stem cell support|
5819020|NCT00003336|Procedure|umbilical cord blood transplantation|One day after the conditioning regimen is completed, patients receive the UCBT.
5819021|NCT00003336|Radiation|radiation therapy|The regimen varies according to the underlying cause of the anemia.Patients receive high-dose chemotherapy and/or radiotherapy as a conditioning regimen beginning 6-9 days before the umbilical cord blood transplant (UCBT).
5819022|NCT00003335|Biological|anti-thymocyte globulin|antithymocyte globulin IV for three days on days -3 to -1
5819025|NCT00003335|Drug|melphalan|melphalan IV for three days on days -4 to -2
5822963|NCT00002068|Drug|Amphotericin B|
5819026|NCT00003335|Drug|methylprednisolone|Methylprednisolone IV for three days on days -3 to -1. Methylprednisolone begin on day -2 and continue for 6 months.
5819027|NCT00003335|Procedure|umbilical cord blood transplantation|On day 0, patients receive umbilical cord blood infusion.
5819028|NCT00003335|Radiation|radiation therapy|9 fractions of total body irradiation (TBI) on days -9 to -5
5819029|NCT00003332|Drug|cisplatin|
5819030|NCT00003332|Drug|gemcitabine hydrochloride|
5819031|NCT00003332|Procedure|surgical procedure|
5819032|NCT00003332|Radiation|radiation therapy|
5819033|NCT00003329|Genetic|gene mapping|
5819034|NCT00003325|Procedure|Sentinel lymph node mapping|Sentinel lymph node mapping
5819035|NCT00003309|Biological|filgrastim|
5819036|NCT00003309|Drug|cisplatin|
5819037|NCT00003309|Drug|cyclophosphamide|
5819038|NCT00003309|Drug|etoposide|
5819039|NCT00003309|Drug|vincristine sulfate|
5819040|NCT00003309|Procedure|adjuvant therapy|
5819041|NCT00003309|Radiation|radiation therapy|
5819042|NCT00003308|Radiation|stereotactic radiosurgery|
5819043|NCT00003292|Drug|ifosfamide|
5819044|NCT00003291|Genetic|cytogenetic analysis|
5819045|NCT00003291|Genetic|mutation analysis|
5819046|NCT00003291|Other|laboratory biomarker analysis|
5819047|NCT00003282|Drug|EF5|Given IV
5819048|NCT00003282|Procedure|therapeutic conventional surgery|Undergo resection
5819049|NCT00003282|Procedure|biopsy|Undergo biopsy
5819050|NCT00003282|Other|pharmacological study|Correlative studies
5819051|NCT00003278|Drug|dexamethasone|
5819052|NCT00003278|Radiation|radiation therapy|
5819053|NCT00003273|Biological|filgrastim|
5819054|NCT00003273|Drug|carboplatin|
5819055|NCT00003273|Drug|cisplatin|
5819056|NCT00003273|Drug|cyclophosphamide|
5819057|NCT00003273|Drug|etoposide|
5819058|NCT00003273|Drug|leucovorin calcium|
5819059|NCT00003273|Drug|methotrexate|
5819060|NCT00003273|Drug|temozolomide|
5819061|NCT00003273|Drug|thiotepa|
5819062|NCT00003273|Drug|vincristine sulfate|
5819063|NCT00003273|Procedure|autologous bone marrow transplantation|
5819064|NCT00003273|Procedure|peripheral blood stem cell transplantation|
5819065|NCT00003273|Radiation|radiation therapy|
5819066|NCT00003268|Drug|amifostine trihydrate|
5819067|NCT00003268|Drug|cytarabine|
5819068|NCT00003268|Drug|idarubicin|
5819069|NCT00003261|Drug|methotrexate|
5819070|NCT00003261|Drug|zidovudine|
5819071|NCT00003261|Procedure|neoadjuvant therapy|
5819072|NCT00003261|Radiation|radiation therapy|
5819073|NCT00003243|Biological|aldesleukin|
5819074|NCT00003243|Biological|filgrastim|
5819075|NCT00003243|Biological|therapeutic allogeneic lymphocytes|
5819076|NCT00003243|Drug|cyclophosphamide|
5819077|NCT00003243|Drug|etoposide|
5819078|NCT00003243|Drug|pegylated liposomal doxorubicin hydrochloride|
5819079|NCT00003216|Drug|fluorouracil|
5819080|NCT00003216|Drug|gemcitabine hydrochloride|
5819081|NCT00003216|Radiation|radiation therapy|
5819082|NCT00003215|Biological|filgrastim|
5819083|NCT00003215|Drug|CHOP regimen|
5819084|NCT00003215|Drug|cyclophosphamide|
5819085|NCT00003215|Drug|cytarabine|
5819086|NCT00003215|Drug|doxorubicin hydrochloride|
5819087|NCT00003215|Drug|etoposide|
5819088|NCT00003215|Drug|leucovorin calcium|
5819089|NCT00003215|Drug|melphalan|
5819090|NCT00003215|Drug|methotrexate|
5819091|NCT00003215|Drug|methylprednisolone|
5819092|NCT00003215|Drug|mitoxantrone hydrochloride|
5819093|NCT00003215|Drug|prednisone|
5819094|NCT00003215|Drug|therapeutic hydrocortisone|
5819095|NCT00003215|Drug|vincristine sulfate|
5819096|NCT00003215|Procedure|bone marrow ablation with stem cell support|
5819097|NCT00003215|Procedure|peripheral blood stem cell transplantation|
5819098|NCT00003215|Radiation|radiation therapy|
5819099|NCT00003204|Drug|cyclophosphamide|Given IV
5819100|NCT00003204|Drug|fludarabine phosphate|Given IV
5819101|NCT00003204|Drug|vincristine sulfate|Given IV
5819102|NCT00003204|Drug|prednisone|Given PO
5819103|NCT00003204|Biological|rituximab|Given IV
5819104|NCT00003204|Other|laboratory biomarker analysis|Correlative studies
5819105|NCT00003199|Drug|tamoxifen citrate|Given orally
5819106|NCT00003199|Drug|busulfan|Given orally
5819107|NCT00003199|Drug|thiotepa|Given IV
5819108|NCT00003199|Drug|melphalan|Given IV
5819109|NCT00003199|Biological|aldesleukin|Given SC
5819110|NCT00003199|Biological|sargramostim|Given SC
5819111|NCT00003199|Procedure|peripheral blood stem cell transplantation|Undergo autologous peripheral blood stem cell infusion
5819112|NCT00003199|Radiation|radiation therapy|May undergo radiotherapy after completion of IL-2/GM-CSF
5819113|NCT00003194|Biological|filgrastim|
5819114|NCT00003194|Drug|carboplatin|
5819115|NCT00003194|Drug|cyclophosphamide|
5819116|NCT00003194|Drug|etoposide|
5819117|NCT00003194|Drug|thiotepa|
5819118|NCT00003194|Drug|topotecan hydrochloride|
5819119|NCT00003194|Procedure|peripheral blood stem cell transplantation|
5819120|NCT00003179|Drug|medroxyprogesterone|
5819121|NCT00003178|Biological|filgrastim|
5819122|NCT00003178|Drug|cladribine|
5819123|NCT00003178|Drug|idarubicin|
5819124|NCT00003174|Drug|bryostatin 1|
5819125|NCT00003174|Drug|cladribine|
5819126|NCT00003159|Drug|carboplatin|
5819127|NCT00003159|Drug|cisplatin|
5819128|NCT00003159|Drug|docetaxel|
5819129|NCT00003159|Drug|gemcitabine hydrochloride|
5819130|NCT00003159|Drug|ifosfamide|
5819131|NCT00003159|Drug|mitomycin C|
5819133|NCT00003159|Drug|vinblastine sulfate|
5819134|NCT00003159|Drug|vinorelbine tartrate|
5819135|NCT00003159|Procedure|conventional surgery|
5819136|NCT00003159|Procedure|neoadjuvant therapy|
5819137|NCT00003153|Biological|therapeutic allogeneic lymphocytes|
5819138|NCT00003145|Drug|Fludarabine Phosphate|Given IV
5819139|NCT00003145|Radiation|Total-Body Irradiation|Undergo TBI
5819140|NCT00003145|Procedure|Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|Undergo allogeneic PBSCT
5819141|NCT00003145|Procedure|Peripheral Blood Stem Cell Transplantation|Undergo allogeneic PBSCT
5819142|NCT00003145|Drug|Cyclosporine|Given PO or IV
5819143|NCT00003145|Drug|Mycophenolate Mofetil|Given PO or IV
5819144|NCT00003145|Biological|Therapeutic Allogeneic Lymphocytes|Given IV
5819145|NCT00003145|Other|Laboratory Biomarker Analysis|Correlative studies
5819146|NCT00003140|Drug|letrozole|Given orally
5819147|NCT00003140|Other|placebo|Given orally
5819148|NCT00003138|Biological|Erythropoietin|Administered at 150 units/kg subcutaneously every day. Rotating sites should be used. The dose should be rounded off to the nearest 1000 U. The dose should be adjusted based on hematocrit.
5819149|NCT00003138|Biological|Filgrastim|G-CSF should start at a dose of 1 mcg/kg per day or 2.5 mcg/kg three times a week subcutaneously. Rotating sites should be used The dose should be rounded off to the nearest 10 mcg.
5819150|NCT00003138|Procedure|Transfusion|Red cell and platelet transfusions
5819151|NCT00003135|Drug|fluorouracil|
5819152|NCT00003135|Drug|pegylated liposomal doxorubicin hydrochloride|
5819153|NCT00003135|Procedure|hyperthermia treatment|
5819154|NCT00003128|Biological|filgrastim|
5819155|NCT00003128|Drug|ifosfamide|
5819156|NCT00003128|Drug|paclitaxel|
5819157|NCT00003122|Procedure|surgical procedure|
5819158|NCT00003119|Biological|filgrastim|
5819159|NCT00003119|Biological|sargramostim|
5819160|NCT00003119|Drug|carboplatin|
5819161|NCT00003119|Drug|cyclophosphamide|
5819162|NCT00003119|Drug|doxorubicin hydrochloride|
5819163|NCT00003119|Drug|etoposide|
5819164|NCT00003119|Procedure|adjuvant therapy|
5819165|NCT00003119|Procedure|conventional surgery|
5819166|NCT00003119|Radiation|radiation therapy|
5819167|NCT00003116|Biological|filgrastim|Filgrastim (G-CSF) is administered subcutaneously twice a day beginning 3 hours after completion of cell infusion and continuing until blood counts recover.
5819168|NCT00003116|Drug|busulfan|high-dose oral busulfan every 6 hours on days -8 to -5
5819169|NCT00003116|Drug|cyclophosphamide|cyclophosphamide IV twice a day on days -4 and -3
5819170|NCT00003116|Drug|cyclosporine|cyclosporine IV over 6 hours on day -1 and then 10 hours on day 0 for 2 doses (allogeneic only)
5819171|NCT00003116|Procedure|bone marrow ablation with stem cell support|
5819172|NCT00003116|Procedure|peripheral blood stem cell transplantation|Allogeneic peripheral blood progenitor cells IV are administered on day 0.
5819173|NCT00003111|Drug|carboplatin|
5819174|NCT00003111|Drug|cisplatin|
5819175|NCT00003111|Drug|irinotecan hydrochloride|
5819176|NCT00003111|Drug|paclitaxel|
5819177|NCT00003111|Procedure|neoadjuvant therapy|
5819178|NCT00003111|Procedure|surgical procedure|
5819179|NCT00003111|Radiation|radiation therapy|
5819180|NCT00003105|Biological|filgrastim|
5819181|NCT00003105|Drug|cisplatin|
5819182|NCT00003105|Drug|doxorubicin hydrochloride|
5819183|NCT00003105|Drug|gemcitabine hydrochloride|
5819184|NCT00003105|Drug|ifosfamide|
5819185|NCT00003105|Drug|paclitaxel|
5819186|NCT00003104|Radiation|radiation therapy|
5819187|NCT00003096|Genetic|DNA ploidy analysis|
5819188|NCT00003096|Genetic|comparative genomic hybridization|
5819189|NCT00003096|Genetic|cytogenetic analysis|
5819190|NCT00003096|Genetic|fluorescence in situ hybridization|
5819191|NCT00003093|Biological|filgrastim|
5819192|NCT00003093|Biological|sargramostim|
5819193|NCT00003093|Drug|carboplatin|
5819194|NCT00003093|Drug|cyclophosphamide|
5819195|NCT00003093|Drug|doxorubicin hydrochloride|
5819196|NCT00003093|Drug|etoposide|
5819197|NCT00003093|Procedure|conventional surgery|
5819198|NCT00003093|Procedure|neoadjuvant therapy|
5819199|NCT00003092|Drug|paclitaxel|
5819200|NCT00003067|Biological|aldesleukin|
5819201|NCT00003067|Biological|lymphokine-activated killer cells|
5819202|NCT00003065|Biological|filgrastim|
5819203|NCT00003065|Drug|paclitaxel|
5819204|NCT00003065|Drug|topotecan hydrochloride|
5819205|NCT00003063|Biological|recombinant interferon alfa|
5819206|NCT00003063|Drug|fluorouracil|
5819207|NCT00003063|Drug|leucovorin calcium|
5819208|NCT00003063|Drug|levamisole hydrochloride|
5819209|NCT00003053|Drug|cisplatin|
5819210|NCT00003053|Drug|etoposide|
5819211|NCT00003053|Procedure|adjuvant therapy|
5819212|NCT00003052|Drug|doxorubicin hydrochloride|
5819213|NCT00003052|Drug|etoposide|
5819214|NCT00003052|Drug|ifosfamide|
5819215|NCT00003052|Procedure|conventional surgery|
5819216|NCT00003052|Procedure|hyperthermia treatment|
5819217|NCT00003052|Radiation|radiation therapy|
5819218|NCT00003049|Drug|fluorouracil|
5819219|NCT00003049|Drug|leucovorin calcium|
5819220|NCT00003049|Procedure|conventional surgery|
5819221|NCT00003049|Radiation|radiation therapy|
5819222|NCT00003042|Biological|filgrastim|
5819223|NCT00003042|Drug|cisplatin|
5819224|NCT00003042|Drug|cyclophosphamide|
5819225|NCT00003042|Drug|doxorubicin hydrochloride|
5819226|NCT00003042|Drug|melphalan|
5819227|NCT00003042|Drug|mesna|
5819228|NCT00003042|Drug|paclitaxel|
5819229|NCT00003042|Drug|tamoxifen citrate|
5822964|NCT00002067|Drug|Megestrol acetate|
5819230|NCT00003042|Procedure|bone marrow ablation with stem cell support|
5819231|NCT00003042|Procedure|conventional surgery|
5819232|NCT00003042|Procedure|peripheral blood stem cell transplantation|
5819233|NCT00003034|Drug|doxorubicin hydrochloride|Given IV
5819234|NCT00003034|Drug|ranpirnase|Given IV
5819235|NCT00003029|Drug|cisplatin|
5819236|NCT00003029|Drug|fluorouracil|
5819237|NCT00003027|Biological|aldesleukin|
5819238|NCT00003027|Biological|filgrastim|
5819239|NCT00003027|Biological|recombinant interferon alfa|
5819240|NCT00003027|Drug|cisplatin|
5819241|NCT00003027|Drug|dacarbazine|
5819242|NCT00003027|Drug|vinblastine|
5819243|NCT00003026|Drug|bicalutamide|
5819244|NCT00003026|Drug|flutamide|
5819245|NCT00003026|Drug|triptorelin|
5819246|NCT00003026|Radiation|radiation therapy|
5819247|NCT00003023|Biological|BCG vaccine|
5819248|NCT00003023|Biological|monoclonal antibody A1G4 anti-idiotype vaccine|
5819249|NCT00003022|Radiation|iodine I 131 monoclonal antibody 3F8|
5819250|NCT00003016|Drug|tamoxifen citrate|
5819251|NCT00003016|Procedure|adjuvant therapy|
5819252|NCT00003013|Drug|CMF regimen|
5819253|NCT00003013|Drug|cyclophosphamide|
5819254|NCT00003013|Drug|doxorubicin hydrochloride|
5819255|NCT00003013|Drug|fluorouracil|
5819256|NCT00003013|Drug|methotrexate|
5819257|NCT00003013|Drug|paclitaxel|
5819258|NCT00003013|Drug|tamoxifen citrate|
5819259|NCT00003013|Procedure|conventional surgery|
5819260|NCT00003013|Radiation|radiation therapy|
5819261|NCT00002996|Drug|flecainide acetate|
5819262|NCT00002995|Biological|dactinomycin|
5819263|NCT00002995|Biological|filgrastim|
5819264|NCT00002995|Biological|sargramostim|
5819265|NCT00002995|Drug|cyclophosphamide|
5819266|NCT00002995|Drug|vincristine sulfate|
5819267|NCT00002995|Radiation|radiation therapy|
5819268|NCT00002990|Biological|BCG vaccine|
5819269|NCT00002986|Drug|carmustine|
5819270|NCT00002986|Drug|topotecan hydrochloride|
5819271|NCT00002982|Biological|filgrastim|
5819272|NCT00002982|Drug|carboplatin|
5819273|NCT00002982|Drug|carmustine|
5819274|NCT00002982|Drug|cytarabine|
5819275|NCT00002982|Drug|etoposide|
5819276|NCT00002982|Drug|ifosfamide|
5819277|NCT00002982|Drug|melphalan|
5819278|NCT00002982|Procedure|autologous bone marrow transplantation|
5819279|NCT00002982|Procedure|peripheral blood stem cell transplantation|
5819280|NCT00002982|Radiation|radiation therapy|
5819281|NCT00002981|Procedure|positron emission tomography|
5819282|NCT00002981|Radiation|fludeoxyglucose F 18|
5819283|NCT00002981|Radiation|methionine C 11|
5819284|NCT00002976|Drug|conjugated estrogens|
5819285|NCT00002975|Drug|aminolevulinic acid|
5819286|NCT00002968|Biological|edrecolomab|Given IV
5819287|NCT00002968|Other|laboratory biomarker analysis|Correlative studies
5819288|NCT00002963|Drug|aminolevulinic acid hydrochloride|
5819289|NCT00002963|Procedure|conventional surgery|
5819290|NCT00002951|Drug|fluorouracil|
5819291|NCT00002951|Drug|hydroxyurea|
5819292|NCT00002951|Procedure|surgical procedure|
5819293|NCT00002951|Radiation|radiation therapy|
5819294|NCT00002948|Biological|filgrastim|
5819295|NCT00002948|Drug|topotecan hydrochloride|
5819296|NCT00002948|Procedure|bone marrow ablation with stem cell support|
5819297|NCT00002948|Procedure|peripheral blood stem cell transplantation|
5819298|NCT00002944|Drug|carboplatin|Given IV
5819299|NCT00002944|Drug|lomustine|Given IV
5819300|NCT00002944|Drug|procarbazine hydrochloride|Given PO
5819301|NCT00002944|Drug|thioguanine|Given PO
5819302|NCT00002944|Drug|vincristine sulfate|Given PO and IV
5819303|NCT00002943|Drug|carboplatin|
5819304|NCT00002943|Drug|cyclophosphamide|
5819305|NCT00002943|Drug|etoposide|
5819306|NCT00002943|Procedure|autologous bone marrow transplantation|
5819307|NCT00002941|Drug|carmustine|
5819308|NCT00002941|Drug|cyclophosphamide|
5819309|NCT00002941|Drug|etoposide|
5819310|NCT00002941|Drug|mesna|
5819311|NCT00002941|Procedure|peripheral blood stem cell transplantation|
5819312|NCT00002938|Procedure|conventional surgery|Salvage prostatectomy
5819313|NCT00002931|Biological|filgrastim|5 ug/kg bid beginning 4 days prior to and continuing through stem cell collection.
5819314|NCT00002931|Drug|carboplatin|AUC=7, daily X 3
5819315|NCT00002931|Drug|etoposide|20 mg/kg by 2 hours infusion daily X 3
5819316|NCT00002931|Drug|ifosfamide|3 gm/m2 IV over 30 minutes X 3 days
5819317|NCT00002931|Drug|paclitaxel|425 mg/m2 as 24 hour continuous infusion
5819318|NCT00002931|Procedure|autologous bone marrow transplantation|Given in two divided infusions on day -2 and day 0
5819319|NCT00002931|Procedure|bone marrow ablation with stem cell support|Two cycles of high dose chemotherapy followed by stem cell reinfusion
5819320|NCT00002926|Drug|cytarabine|
5819321|NCT00002926|Drug|etoposide|
5819322|NCT00002926|Drug|idarubicin|
5819323|NCT00002926|Procedure|allogeneic bone marrow transplantation|
5819324|NCT00002926|Procedure|peripheral blood stem cell transplantation|
5819325|NCT00002920|Drug|medroxyprogesterone|
5819326|NCT00002920|Drug|tamoxifen citrate|
5819327|NCT00002920|Procedure|adjuvant therapy|
5819328|NCT00002916|Biological|human papillomavirus 16 E7 peptide|
5819329|NCT00002916|Biological|synthetic human papillomavirus 16 E6 peptide|
5819330|NCT00002916|Procedure|adjuvant therapy|
5819331|NCT00002916|Procedure|surgical procedure|
5819332|NCT00002916|Radiation|radiation therapy|
5819333|NCT00002913|Drug|paclitaxel|Given IV
5819335|NCT00002913|Drug|topotecan hydrochloride|Given IV
5819336|NCT00002913|Biological|filgrastim|Given SC
5819337|NCT00002900|Procedure|management of therapy complications|
5819338|NCT00002899|Procedure|adjuvant therapy|
5819339|NCT00002899|Radiation|radiation therapy|
5819340|NCT00002899|Radiation|stereotactic radiosurgery|
5819341|NCT00002898|Biological|dactinomycin|
5819342|NCT00002898|Drug|carboplatin|
5819343|NCT00002898|Drug|cyclophosphamide|
5819344|NCT00002898|Drug|epirubicin hydrochloride|
5819345|NCT00002898|Drug|etoposide|
5819346|NCT00002898|Drug|ifosfamide|
5819347|NCT00002898|Drug|vincristine sulfate|
5819348|NCT00002898|Procedure|adjuvant therapy|
5819349|NCT00002898|Procedure|conventional surgery|
5819350|NCT00002898|Procedure|neoadjuvant therapy|
5819351|NCT00002898|Radiation|brachytherapy|
5819352|NCT00002898|Radiation|radiation therapy|
5819353|NCT00002895|Drug|chemotherapy|
5819354|NCT00002894|Drug|carboplatin|
5819355|NCT00002894|Drug|cisplatin|
5819356|NCT00002894|Drug|paclitaxel|
5819357|NCT00002883|Drug|cisplatin|
5819358|NCT00002883|Drug|fluorouracil|
5819359|NCT00002883|Procedure|adjuvant therapy|
5819360|NCT00002883|Procedure|conventional surgery|
5819361|NCT00002883|Procedure|neoadjuvant therapy|
5819362|NCT00002882|Biological|Aldesleukin (IL-2)|Infusion for a total of 96 hours on days 1-4
5819363|NCT00002882|Biological|Recombinant Interferon Alfa (IFN-A)|"IFN-A Therapy Groups:~Schedule A: IV IFN-A induction 5 times a week for 4 weeks followed by subcutaneous IFN-A maintenance 3 times a week for 48 weeks.~Schedule B: Subcutaneous IFN-A 3 times a week for 52 weeks~Adjuvant Biochemotherapy Group: IFN-A is given subcutaneously on days 1-5"
5819364|NCT00002882|Drug|Cisplatin|IV Days 1-4
5819365|NCT00002882|Drug|Dacarbazine|IVPB on day 1
5819366|NCT00002882|Drug|Vinblastine|IVPB on days 1-4
5819367|NCT00002882|Procedure|Adjuvant Therapy|Patients receiving adjuvant radiotherapy will start adjuvant systemic therapy within 8 weeks from lymphadenectomy and a week after completion of and recovery from radiotherapy.
5819368|NCT00002874|Drug|bicalutamide|One (150 mg) tablet by mouth daily for two years beginning immediately upon, or just prior to, the initiation of irradiation.
5819369|NCT00002874|Radiation|radiation therapy|64.8 Gy in 36 fractions (1.8 Gy in 5 daily sessions per week) to the original prostate volume, the tumor resection bed, and the proximal membranous urethra.
5819370|NCT00002874|Drug|placebo|One tablet by mouth daily for two years beginning immediately upon, or just prior to, the initiation of irradiation.
5819371|NCT00002860|Procedure|Surgery|Complete surgical resection of metastatic melanoma
5819372|NCT00002855|Drug|Bicalutamide|
5819373|NCT00002855|Drug|Doxorubicin hydrochloride|
5819374|NCT00002855|Drug|Estramustine Phosphate Sodium|
5819375|NCT00002855|Drug|Flutamide|
5819376|NCT00002855|Drug|Ketoconazole|
5819377|NCT00002855|Drug|Nilutamide|
5819378|NCT00002855|Drug|Therapeutic Hydrocortisone|
5819379|NCT00002855|Drug|Vinblastine|
5819380|NCT00002855|Procedure|Conventional Surgery|Surgical castration
5819381|NCT00002854|Biological|filgrastim|
5819382|NCT00002854|Drug|carboplatin|
5819383|NCT00002854|Drug|cisplatin|
5819384|NCT00002854|Drug|cyclophosphamide|
5819385|NCT00002854|Drug|etoposide|
5819386|NCT00002854|Drug|ifosfamide|
5819387|NCT00002854|Drug|mesna|
5819388|NCT00002854|Drug|paclitaxel|
5819389|NCT00002854|Procedure|peripheral blood stem cell transplantation|
5819390|NCT00002852|Drug|paclitaxel|Given IV
5819391|NCT00002852|Drug|carboplatin|Given IV
5819392|NCT00002852|Procedure|therapeutic conventional surgery|Undergo surgery
5819393|NCT00002851|Procedure|adjuvant therapy|
5819394|NCT00002851|Radiation|low-LET electron therapy|
5819395|NCT00002851|Radiation|low-LET photon therapy|
5819396|NCT00002850|Drug|ciprofloxacin|Begin oral ciprofloxacin when they start chemotherapy for multiple myeloma. Assigned treatment consists of ciprofloxacin (Cipro 500 mg po tablet every 12 hours for two months. The patient will continue to be observed one additional month on study continuing regular myeloma chemotherapy.
5819397|NCT00002850|Drug|ofloxacin|Begin oral ofloxacin when they start chemotherapy for multiple myeloma. Assigned treatment consists of ofloxacin (500 mg po tablet every 12 hours for two months. The patient will continue to be observed one additional month on study continuing regular myeloma chemotherapy.
5819398|NCT00002850|Drug|160 mg trimethoprim and 800 mg sulfamethoxazole|Begin oral TMP-SMX when they start chemotherapy for multiple myeloma. Assigned treatment consists of TMP-SMX (Septra® or Bactrim®) 1 DS tablet [TMP-SMX DS = 160 mg trimethoprim and 800 mg sulfamethoxazole] every 12 hours for two months..
5819399|NCT00002849|Biological|recombinant interferon alfa|first 2 years
5819400|NCT00002849|Drug|dexamethasone|40 mg*/d PO 1 - 4, 9 - 12, 17-20 q 35 days for 3 cycles*
5819401|NCT00002848|Procedure|psychosocial assessment and care|
5819402|NCT00002848|Procedure|quality-of-life assessment|
5819403|NCT00002847|Biological|aldesleukin|
5819404|NCT00002847|Biological|recombinant interferon alfa|
5819405|NCT00002847|Procedure|conventional surgery|
5819406|NCT00002846|Biological|aldesleukin|
5819407|NCT00002846|Procedure|conventional surgery|
5819408|NCT00002842|Drug|floxuridine|Starting dose of 0.2 mg/kg/day for 14 consecutive days.
5819409|NCT00002842|Drug|fluorouracil|300 mg/m2/day by intravenous bolus 24 hours apart for 5 consecutive days.
5819410|NCT00002842|Drug|leucovorin calcium|500 mg/m2/day by continuous intravenous infusion beginning 24 hours prior to the first dose of 5-FU and continuing until 12 hours following the last dose of 5-FU.
5819411|NCT00002842|Procedure|adjuvant therapy|Chemotherapy given after hepatic resection
5819412|NCT00002842|Procedure|conventional surgery|Hepatic resection
5819413|NCT00002839|Drug|cisplatin|
5819414|NCT00002839|Drug|fluorouracil|
5819415|NCT00002839|Procedure|conventional surgery|
5819416|NCT00002839|Procedure|neoadjuvant therapy|
5819417|NCT00002839|Radiation|radiation therapy|
5819418|NCT00002810|Biological|filgrastim|
5819419|NCT00002810|Drug|melphalan|
5819420|NCT00002810|Procedure|bone marrow ablation with stem cell support|
5819421|NCT00002810|Procedure|peripheral blood stem cell transplantation|
5819422|NCT00002809|Biological|anti-thymocyte globulin|
5819423|NCT00002809|Biological|filgrastim|
5819424|NCT00002809|Biological|sargramostim|
5819425|NCT00002809|Biological|therapeutic immune globulin|
5819426|NCT00002809|Drug|cyclophosphamide|
5819427|NCT00002809|Drug|methotrexate|
5819428|NCT00002809|Drug|tacrolimus|
5819429|NCT00002809|Procedure|allogeneic bone marrow transplantation|
5819430|NCT00002809|Radiation|radiation therapy|
5819431|NCT00002807|Radiation|radiation therapy|45 Gy in 25 fractions over 5 weeks
5819432|NCT00002798|Drug|asparaginase|
5819433|NCT00002798|Drug|daunorubicin hydrochloride|
5819434|NCT00002798|Drug|fludarabine phosphate|
5819435|NCT00002798|Drug|therapeutic hydrocortisone|
5819436|NCT00002798|Procedure|allogeneic bone marrow transplantation|
5819437|NCT00002798|Radiation|3-dimensional conformal radiation therapy|
5819438|NCT00002798|Biological|filgrastim|Given SC
5819439|NCT00002798|Drug|cytarabine|Given IV or IT
5819440|NCT00002798|Drug|idarubicin|Given IV
5819441|NCT00002798|Drug|dexamethasone|Given PO
5819442|NCT00002798|Drug|thioguanine|Given PO
5819443|NCT00002798|Drug|etoposide|Given IV
5819444|NCT00002798|Drug|methotrexate|Given IT
5819445|NCT00002798|Drug|cyclophosphamide|Given IV
5819446|NCT00002798|Biological|aldesleukin|
5819447|NCT00002798|Drug|busulfan|
5819448|NCT00002796|Drug|fluorouracil|Given IV
5819449|NCT00002796|Drug|sodium phenylbutyrate|Given IV
5819450|NCT00002796|Drug|indomethacin|Given orally
5819451|NCT00002796|Biological|recombinant interferon gamma|Given subcutaneously
5819452|NCT00002792|Drug|busulfan|
5819453|NCT00002792|Drug|cyclophosphamide|
5819454|NCT00002792|Drug|cyclosporine|
5819455|NCT00002792|Drug|methotrexate|
5819456|NCT00002792|Drug|tacrolimus|
5819457|NCT00002792|Procedure|allogeneic bone marrow transplantation|
5819458|NCT00002792|Procedure|peripheral blood stem cell transplantation|
5819459|NCT00002778|Biological|sargramostim|
5819460|NCT00002778|Biological|therapeutic allogeneic lymphocytes|
5819461|NCT00002778|Procedure|allogeneic bone marrow transplantation|
5819462|NCT00002778|Procedure|in vitro-treated bone marrow transplantation|
5819463|NCT00002771|Biological|recombinant interferon alfa|
5819464|NCT00002771|Drug|busulfan|
5819465|NCT00002771|Drug|cytarabine|
5819466|NCT00002771|Drug|hydroxyurea|
5819467|NCT00002771|Drug|idarubicin|
5819468|NCT00002771|Procedure|allogeneic bone marrow transplantation|
5819469|NCT00002771|Procedure|autologous bone marrow transplantation|
5819470|NCT00002771|Procedure|peripheral blood stem cell transplantation|
5819471|NCT00002771|Radiation|radiation therapy|
5819472|NCT00002766|Biological|dactinomycin|
5819473|NCT00002766|Biological|sargramostim|
5819474|NCT00002766|Drug|carmustine|
5819475|NCT00002766|Drug|cyclophosphamide|
5819476|NCT00002766|Drug|cytarabine|
5819477|NCT00002766|Drug|daunorubicin hydrochloride|
5819478|NCT00002766|Drug|doxorubicin hydrochloride|
5819479|NCT00002766|Drug|etoposide|
5819480|NCT00002766|Drug|mercaptopurine|
5819481|NCT00002766|Drug|methotrexate|
5819482|NCT00002766|Drug|mitoxantrone hydrochloride|
5819483|NCT00002766|Drug|pegaspargase|
5819484|NCT00002766|Drug|prednisone|
5819485|NCT00002766|Drug|vincristine sulfate|
5819486|NCT00002766|Radiation|radiation therapy|
5819487|NCT00002762|Behavioral|patient interviewing to obtain menstrual history|
5819488|NCT00002762|Procedure|blood sampling|
5819489|NCT00002757|Biological|filgrastim|
5819490|NCT00002757|Drug|cyclophosphamide|
5819491|NCT00002757|Drug|cytarabine|
5819492|NCT00002757|Drug|doxorubicin hydrochloride|
5819493|NCT00002757|Drug|etoposide|
5819494|NCT00002757|Drug|methotrexate|
5819495|NCT00002757|Drug|prednisolone|
5819496|NCT00002757|Drug|prednisone|
5819497|NCT00002757|Drug|therapeutic hydrocortisone|
5819498|NCT00002757|Drug|vincristine sulfate|
5819499|NCT00002756|Biological|filgrastim|
5819500|NCT00002756|Drug|asparaginase|
5819501|NCT00002756|Drug|cyclophosphamide|
5819502|NCT00002756|Drug|cytarabine|
5819503|NCT00002756|Drug|daunorubicin hydrochloride|
5819504|NCT00002756|Drug|etoposide|
5819505|NCT00002756|Drug|leucovorin calcium|
5819506|NCT00002756|Drug|mercaptopurine|
5819507|NCT00002756|Drug|methotrexate|
5819508|NCT00002756|Drug|prednisone|
5819509|NCT00002756|Drug|therapeutic hydrocortisone|
5819510|NCT00002756|Drug|vincristine sulfate|
5819511|NCT00002746|Biological|aldesleukin|
5819512|NCT00002738|Drug|leucovorin calcium|
5819513|NCT00002738|Drug|trimetrexate glucuronate|
5819514|NCT00002727|Radiation|radiation therapy|
5819515|NCT00002720|Drug|tamoxifen citrate|
5819516|NCT00002720|Procedure|conventional surgery|
5819517|NCT00002718|Biological|anti-thymocyte globulin|
5819518|NCT00002718|Biological|filgrastim|
5819519|NCT00002718|Drug|cyclophosphamide|
5819520|NCT00002718|Drug|cytarabine|
5819521|NCT00002718|Drug|methylprednisolone|
5819522|NCT00002718|Drug|thiotepa|
5819523|NCT00002718|Procedure|in vitro-treated bone marrow transplantation|
5822965|NCT00002066|Drug|Thymopentin|
5819524|NCT00002718|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5819525|NCT00002718|Radiation|radiation therapy|
5819526|NCT00002716|Drug|dexamethasone|
5819527|NCT00002716|Drug|floxuridine|
5819528|NCT00002716|Drug|fluorouracil|
5819529|NCT00002716|Drug|leucovorin calcium|
5819530|NCT00002716|Procedure|laparotomy|
5819531|NCT00002716|Procedure|conventional surgery|
5819532|NCT00002715|Biological|bleomycin sulfate|
5819533|NCT00002715|Drug|Stanford V regimen|
5819534|NCT00002715|Drug|doxorubicin hydrochloride|
5819535|NCT00002715|Drug|etoposide|
5819536|NCT00002715|Drug|mechlorethamine hydrochloride|
5819537|NCT00002715|Drug|prednisone|
5819538|NCT00002715|Drug|vinblastine|
5819539|NCT00002715|Drug|vincristine sulfate|
5819540|NCT00002706|Procedure|Laparoscopic Surgery|Undergo vaginal hysterectomy and BSO via laparoscopy
5819541|NCT00002706|Other|Quality-of-Life Assessment|Ancillary studies
5819542|NCT00002706|Procedure|Therapeutic Conventional Surgery|Undergo total abdominal hysterectomy and BSO via conventional laparotomy
5819543|NCT00002702|Biological|aldesleukin|
5819544|NCT00002702|Procedure|adjuvant therapy|
5819545|NCT00002702|Procedure|conventional surgery|
5819546|NCT00002702|Procedure|neoadjuvant therapy|
5819547|NCT00002702|Radiation|radiation therapy|
5819548|NCT00002700|Drug|asparaginase|
5819549|NCT00002700|Drug|cyclophosphamide|
5819550|NCT00002700|Drug|cytarabine|
5819551|NCT00002700|Drug|daunorubicin hydrochloride|
5819552|NCT00002700|Drug|dexamethasone|
5819553|NCT00002700|Drug|doxorubicin hydrochloride|
5819554|NCT00002700|Drug|leucovorin calcium|
5819555|NCT00002700|Drug|mercaptopurine|
5819556|NCT00002700|Drug|methotrexate|
5819557|NCT00002700|Drug|mitoxantrone hydrochloride|
5819558|NCT00002700|Drug|prednisolone|
5819559|NCT00002700|Drug|prednisone|
5819560|NCT00002700|Drug|therapeutic hydrocortisone|
5819561|NCT00002700|Drug|vincristine sulfate|
5819562|NCT00002700|Procedure|allogeneic bone marrow transplantation|
5819563|NCT00002700|Procedure|autologous bone marrow transplantation|
5819564|NCT00002700|Radiation|radiation therapy|
5819565|NCT00002697|Biological|filgrastim|
5819566|NCT00002697|Biological|sargramostim|
5819567|NCT00002697|Drug|carboplatin|
5819568|NCT00002697|Drug|etoposide|
5819569|NCT00002697|Drug|ifosfamide|
5819570|NCT00002697|Procedure|autologous bone marrow transplantation|
5819571|NCT00002697|Procedure|bone marrow ablation with stem cell support|
5819572|NCT00002697|Procedure|peripheral blood stem cell transplantation|
5819573|NCT00002697|Radiation|radiation therapy|
5819574|NCT00002696|Drug|CAF regimen|
5819575|NCT00002696|Drug|CMF regimen|
5819576|NCT00002696|Drug|cyclophosphamide|
5819577|NCT00002696|Drug|doxorubicin hydrochloride|
5819578|NCT00002696|Drug|fluorouracil|
5819579|NCT00002696|Drug|methotrexate|
5819580|NCT00002696|Procedure|adjuvant therapy|
5819581|NCT00002696|Procedure|conventional surgery|
5819582|NCT00002696|Procedure|neoadjuvant therapy|
5819583|NCT00002696|Radiation|radiation therapy|
5819584|NCT00002689|Drug|dexamethasone|
5819585|NCT00002689|Drug|fluorouracil|
5819586|NCT00002689|Radiation|brachytherapy|
5819587|NCT00002689|Radiation|phosphorus P32|
5819588|NCT00002689|Radiation|radiation therapy|
5819589|NCT00002687|Biological|aldesleukin|
5819590|NCT00002684|Drug|cisplatin|
5819591|NCT00002684|Drug|ifosfamide|
5819592|NCT00002684|Drug|paclitaxel|
5819593|NCT00002681|Biological|aldesleukin|
5819594|NCT00002681|Biological|daclizumab|
5819595|NCT00002678|Drug|dexamethasone|40 mg daily for four days given orally and repeated every 28 days should commence on day 29 of the twelfth cycle of induction therapy.
5819596|NCT00002678|Drug|melphalan|9 mg/m2 daily for 4 days given orally on an empty stomach every 4 weeks
5819597|NCT00002678|Drug|prednisone|100 mg daily for 4 days given orally on a full stomach with each cycle of melphalan
5819598|NCT00002668|Behavioral|Observation|
5819599|NCT00002668|Behavioral|Educational Intervention and Behavioral Skills Training|
5819600|NCT00002663|Biological|allogeneic Epstein-Barr virus-specific cytotoxic T lymphocytes|EBV-CTLs are cytotoxic T lymphocytes that specifically kill cells presenting EBV protein antigens including EBV-transformed B lymphocytes responsible for EBV-associated lymphomas and lymphoproliferative disorders.
5819601|NCT00002662|Drug|docetaxel|
5819602|NCT00002662|Drug|paclitaxel|
5819603|NCT00002651|Drug|bicalutamide|Given orally
5819604|NCT00002651|Drug|goserelin acetate|Given subcutaneously
5819605|NCT00002651|Other|clinical observation|Patients undergo observation in the absence of rising prostate-specific antigen (PSA) or clinical symptoms of progressive disease.
5819606|NCT00002649|Biological|aldesleukin|Given IV
5819607|NCT00002649|Biological|filgrastim|Given SC or IV
5819608|NCT00002649|Drug|cyclophosphamide|Given IV
5819609|NCT00002649|Drug|etoposide|Given IV
5819610|NCT00002649|Radiation|radiation therapy|Undergo radiation therapy
5819611|NCT00002649|Procedure|peripheral blood stem cell transplantation|Undergo autologous peripheral blood stem cell transplant
5819612|NCT00002649|Procedure|bone marrow ablation with stem cell support|Undergo bone marrow ablation with stem cell support
5819613|NCT00002647|Drug|verteporfin|
5819614|NCT00002647|Procedure|conventional surgery|
5819615|NCT00002641|Biological|filgrastim|
5819616|NCT00002641|Drug|doxorubicin hydrochloride|
5819617|NCT00002641|Drug|ifosfamide|
5819618|NCT00002641|Drug|isolated perfusion|
5819619|NCT00002641|Procedure|adjuvant therapy|
5819620|NCT00002641|Procedure|conventional surgery|
5819621|NCT00002641|Radiation|radiation therapy|
5819622|NCT00002633|Drug|bicalutamide|Antiandrogen (optional with orchiectomy) Flutamide 250 mg po TID or Nilutamide 100 mg po TID x 1 mo; then 150 mg po QD or Bicalutamide 50 mg po QD PLUS (patient's choice) Bilateral orchiectomy or LHRH agonist Goserelin 3.6 mg SC (abd) q28d or 10.8 mg SC (abd) Q3mos or Leuprolide 7.5 mg IM q28d (Leuprorelin 3.75 mg) or 22.5 mg IM Q3mos (Leuprorelin 11.25 mg) or 30 mg IM Q4mos or Buserelin 6.3mg SC (abd) Q8wk or 9.45mg SC (abd) Q12wk
5819623|NCT00002633|Drug|buserelin|Antiandrogen (optional with orchiectomy) Flutamide 250 mg po TID or Nilutamide 100 mg po TID x 1 mo; then 150 mg po QD or Bicalutamide 50 mg po QD PLUS (patient's choice) Bilateral orchiectomy or LHRH agonist Goserelin 3.6 mg SC (abd) q28d or 10.8 mg SC (abd) Q3mos or Leuprolide 7.5 mg IM q28d (Leuprorelin 3.75 mg) or 22.5 mg IM Q3mos (Leuprorelin 11.25 mg) or 30 mg IM Q4mos or Buserelin 6.3mg SC (abd) Q8wk or 9.45mg SC (abd) Q12wk
5819624|NCT00002633|Drug|flutamide|Antiandrogen (optional with orchiectomy) Flutamide 250 mg po TID or Nilutamide 100 mg po TID x 1 mo; then 150 mg po QD or Bicalutamide 50 mg po QD PLUS (patient's choice) Bilateral orchiectomy or LHRH agonist Goserelin 3.6 mg SC (abd) q28d or 10.8 mg SC (abd) Q3mos or Leuprolide 7.5 mg IM q28d (Leuprorelin 3.75 mg) or 22.5 mg IM Q3mos (Leuprorelin 11.25 mg) or 30 mg IM Q4mos or Buserelin 6.3mg SC (abd) Q8wk or 9.45mg SC (abd) Q12wk
5819625|NCT00002633|Drug|goserelin|Antiandrogen (optional with orchiectomy) Flutamide 250 mg po TID or Nilutamide 100 mg po TID x 1 mo; then 150 mg po QD or Bicalutamide 50 mg po QD PLUS (patient's choice) Bilateral orchiectomy or LHRH agonist Goserelin 3.6 mg SC (abd) q28d or 10.8 mg SC (abd) Q3mos or Leuprolide 7.5 mg IM q28d (Leuprorelin 3.75 mg) or 22.5 mg IM Q3mos (Leuprorelin 11.25 mg) or 30 mg IM Q4mos or Buserelin 6.3mg SC (abd) Q8wk or 9.45mg SC (abd) Q12wk
5819626|NCT00002633|Drug|leuprolide acetate|Antiandrogen (optional with orchiectomy) Flutamide 250 mg po TID or Nilutamide 100 mg po TID x 1 mo; then 150 mg po QD or Bicalutamide 50 mg po QD PLUS (patient's choice) Bilateral orchiectomy or LHRH agonist Goserelin 3.6 mg SC (abd) q28d or 10.8 mg SC (abd) Q3mos or Leuprolide 7.5 mg IM q28d (Leuprorelin 3.75 mg) or 22.5 mg IM Q3mos (Leuprorelin 11.25 mg) or 30 mg IM Q4mos or Buserelin 6.3mg SC (abd) Q8wk or 9.45mg SC (abd) Q12wk
5819627|NCT00002633|Drug|nilutamide|Antiandrogen (optional with orchiectomy) Flutamide 250 mg po TID or Nilutamide 100 mg po TID x 1 mo; then 150 mg po QD or Bicalutamide 50 mg po QD PLUS (patient's choice) Bilateral orchiectomy or LHRH agonist Goserelin 3.6 mg SC (abd) q28d or 10.8 mg SC (abd) Q3mos or Leuprolide 7.5 mg IM q28d (Leuprorelin 3.75 mg) or 22.5 mg IM Q3mos (Leuprorelin 11.25 mg) or 30 mg IM Q4mos or Buserelin 6.3mg SC (abd) Q8wk or 9.45mg SC (abd) Q12wk
5819628|NCT00002633|Procedure|orchiectomy|Optional orchiectomy
5819629|NCT00002633|Radiation|radiation therapy|Radical Radiation Therapy - (65-69 Gy; 35-37 treatments)
5819630|NCT00002624|Procedure|adjuvant therapy|
5819631|NCT00002624|Procedure|diagnostic thoracoscopy|
5819632|NCT00002624|Procedure|therapeutic thoracoscopy|
5819633|NCT00002624|Procedure|video-assisted surgery|
5819634|NCT00002624|Radiation|radiation therapy|
5819635|NCT00002623|Drug|carboplatin|
5819636|NCT00002623|Drug|cisplatin|
5819637|NCT00002623|Procedure|conventional surgery|
5819638|NCT00002623|Radiation|radiation therapy|
5819639|NCT00002615|Drug|cisplatin|
5819640|NCT00002615|Drug|epirubicin hydrochloride|
5819641|NCT00002615|Drug|fluorouracil|
5819642|NCT00002615|Procedure|conventional surgery|
5819643|NCT00002611|Biological|dactinomycin|
5819644|NCT00002611|Biological|filgrastim|
5819645|NCT00002611|Drug|cyclophosphamide|
5819646|NCT00002611|Drug|doxorubicin hydrochloride|Source and Pharmacology: An anthracycline antibiotic isolated from cultures of Streptomyces peucetius. Binds to DNA and inhibits nucleic acid synthesis, with its major lethal effect occurring during the S phase of the cell cycle. Has some topoisomerase II inhibitory activity. Since it is primarily excreted by the liver, any liver impairment may enhance toxicity. 40% to 50% is excreted in the bile; <5% in the urine. The drug has a very short initial t½ of <20 minutes and a terminal t½ of 17 hours. Animal studies indicate cytotoxic levels persist in tissue for as long as 24 hours.
5819647|NCT00002611|Drug|etoposide|
5819648|NCT00002611|Drug|vincristine sulfate|
5819649|NCT00002611|Procedure|conventional surgery|
5819650|NCT00002611|Radiation|radiation therapy|
5819651|NCT00002610|Biological|dactinomycin|
5819652|NCT00002610|Biological|filgrastim|
5819653|NCT00002610|Drug|carboplatin|
5819654|NCT00002610|Drug|cyclophosphamide|
5819655|NCT00002610|Drug|doxorubicin hydrochloride|
5819656|NCT00002610|Drug|etoposide|
5819657|NCT00002610|Drug|vincristine sulfate|IV
5819658|NCT00002610|Procedure|conventional surgery|
5819659|NCT00002610|Radiation|radiation therapy|
5819660|NCT00002608|Drug|cisplatin|
5819661|NCT00002608|Drug|doxorubicin hydrochloride|
5819662|NCT00002608|Drug|tamoxifen citrate|
5819663|NCT00002608|Procedure|conventional surgery|
5819664|NCT00002608|Radiation|radiation therapy|
5819665|NCT00002598|Biological|recombinant interferon alfa|
5819666|NCT00002598|Biological|sargramostim|
5819667|NCT00002598|Drug|cyclophosphamide|
5819668|NCT00002598|Drug|cytarabine|
5819669|NCT00002598|Drug|etoposide|
5819670|NCT00002598|Drug|methotrexate|
5819671|NCT00002598|Drug|mitoxantrone hydrochloride|
5819672|NCT00002598|Procedure|bone marrow ablation with stem cell support|
5819673|NCT00002598|Radiation|radiation therapy|
5819674|NCT00002596|Biological|bleomycin sulfate|
5819675|NCT00002596|Biological|filgrastim|
5819676|NCT00002596|Drug|carboplatin|
5819677|NCT00002596|Drug|cisplatin|
5819678|NCT00002596|Drug|cyclophosphamide|
5819679|NCT00002596|Drug|etoposide|
5819680|NCT00002596|Procedure|autologous bone marrow transplantation|
5819681|NCT00002596|Procedure|bone marrow ablation with stem cell support|
5819682|NCT00002596|Procedure|conventional surgery|
5819683|NCT00002596|Procedure|peripheral blood stem cell transplantation|
5819684|NCT00002596|Radiation|radiation therapy|
5819685|NCT00002594|Biological|Sargramostim|Given IV
5819686|NCT00002594|Drug|cyclophosphamide|Given IV
5819688|NCT00002594|Procedure|autologous bone marrow transplantation|
5819689|NCT00002594|Procedure|bone marrow ablation with stem cell support|
5819690|NCT00002594|Procedure|peripheral blood stem cell transplantation|
5819691|NCT00002589|Biological|aldesleukin|
5819692|NCT00002589|Biological|muromonab-CD3|
5819693|NCT00002589|Biological|therapeutic autologous lymphocytes|
5819694|NCT00002589|Procedure|adjuvant therapy|
5819695|NCT00002586|Drug|13-cis retinoic acid|
5819696|NCT00002586|Dietary Supplement|Tocopherol|
5819697|NCT00002569|Drug|lomustine|
5819698|NCT00002569|Drug|procarbazine hydrochloride|
5819699|NCT00002569|Drug|vincristine sulfate|
5819700|NCT00002569|Radiation|radiation therapy|
5819701|NCT00002560|Biological|monoclonal antibody 3F8|
5819702|NCT00002560|Biological|sargramostim|
5819703|NCT00002558|Biological|filgrastim|
5819704|NCT00002558|Drug|carboplatin|
5819705|NCT00002558|Drug|etoposide|
5819706|NCT00002558|Drug|ifosfamide|
5819707|NCT00002558|Drug|paclitaxel|
5819708|NCT00002558|Procedure|peripheral blood stem cell transplantation|
5819709|NCT00002556|Drug|vincristine sulfate|Given IV
5819710|NCT00002556|Drug|carmustine|Given IV
5819711|NCT00002556|Drug|melphalan|Given PO
5819712|NCT00002556|Drug|cyclophosphamide|Given IV
5819713|NCT00002556|Drug|prednisone|Given PO
5819714|NCT00002556|Biological|recombinant interferon alfa-2b|Given SC
5819715|NCT00002556|Other|laboratory biomarker analysis|Correlative studies
5819716|NCT00002546|Drug|cisplatin|
5819717|NCT00002546|Drug|ifosfamide|
5819718|NCT00002546|Procedure|adjuvant therapy|
5819719|NCT00002546|Radiation|radiation therapy|
5819720|NCT00002544|Drug|docetaxel|
5819721|NCT00002544|Drug|mitoxantrone hydrochloride|
5819722|NCT00002528|Drug|tamoxifen citrate|20 mg daily beginning within 6 weeks of surgery for 5 years or until relapse, whichever occurs first.
5819723|NCT00002528|Procedure|conventional surgery|Either total mastectomy or, optionally if the tumor was smaller than 5 cm, a breast conserving procedure (lumpectomy or quadrantectomy).
5819724|NCT00002528|Radiation|radiation therapy|No radiotherapy is to be given after mastectomy. Radiotherapy is optional after breast conserving surgery according to prospectively determined guidelines within each institution. It should be given to the breast only and not to the draining node areas.
5819725|NCT00002528|Procedure|Axillary clearance|Axillary node dissection.
5819726|NCT00002523|Drug|fluorouracil|
5819727|NCT00002523|Drug|leucovorin calcium|
5819728|NCT00002523|Procedure|conventional surgery|
5819729|NCT00002523|Radiation|radiation therapy|
5819730|NCT00002522|Drug|cisplatin|
5819731|NCT00002522|Drug|cyclophosphamide|
5819732|NCT00002522|Drug|etoposide|
5819733|NCT00002522|Procedure|autologous bone marrow transplantation|
5819734|NCT00002522|Procedure|bone marrow ablation with stem cell support|
5819735|NCT00002522|Procedure|peripheral blood stem cell transplantation|
5819736|NCT00002522|Procedure|syngeneic bone marrow transplantation|
5819737|NCT00002522|Radiation|radiation therapy|
5819738|NCT00002521|Drug|cisplatin|
5819739|NCT00002521|Drug|cyclophosphamide|
5819740|NCT00002521|Drug|etoposide|
5819741|NCT00002521|Procedure|autologous bone marrow transplantation|
5819742|NCT00002521|Procedure|bone marrow ablation with stem cell support|
5819743|NCT00002521|Procedure|peripheral blood stem cell transplantation|
5819744|NCT00002521|Procedure|syngeneic bone marrow transplantation|
5819745|NCT00002521|Radiation|radiation therapy|
5819746|NCT00002517|Drug|cytarabine|
5819747|NCT00002517|Drug|daunorubicin hydrochloride|
5819748|NCT00002517|Drug|dexamethasone|
5819749|NCT00002517|Drug|etoposide|
5819750|NCT00002517|Drug|idarubicin|
5819751|NCT00002517|Drug|mitoxantrone hydrochloride|
5819752|NCT00002517|Drug|thioguanine|
5819753|NCT00002517|Procedure|allogeneic bone marrow transplantation|
5819754|NCT00002517|Radiation|radiation therapy|
5819755|NCT00002515|Biological|filgrastim|
5819756|NCT00002515|Drug|carboplatin|
5819757|NCT00002515|Drug|thiotepa|
5819758|NCT00002515|Drug|topotecan hydrochloride|
5819759|NCT00002515|Procedure|autologous bone marrow transplantation|
5819760|NCT00002515|Procedure|bone marrow ablation with stem cell support|
5819761|NCT00002515|Procedure|in vitro-treated bone marrow transplantation|
5819762|NCT00002514|Biological|sargramostim|
5819763|NCT00002514|Drug|asparaginase|
5819764|NCT00002514|Drug|cyclophosphamide|
5819765|NCT00002514|Drug|cytarabine|
5819766|NCT00002514|Drug|daunorubicin hydrochloride|
5819767|NCT00002514|Drug|dexamethasone|
5819768|NCT00002514|Drug|etoposide|
5819769|NCT00002514|Drug|imatinib mesylate|
5819770|NCT00002514|Drug|leucovorin calcium|
5819771|NCT00002514|Drug|mercaptopurine|
5819772|NCT00002514|Drug|methotrexate|
5819773|NCT00002514|Drug|prednisone|
5819774|NCT00002514|Drug|thioguanine|
5819775|NCT00002514|Drug|vincristine sulfate|
5819776|NCT00002514|Procedure|allogeneic bone marrow transplantation|
5819777|NCT00002514|Procedure|autologous bone marrow transplantation|
5819778|NCT00002514|Procedure|peripheral blood stem cell transplantation|
5819779|NCT00002514|Radiation|radiation therapy|
5819780|NCT00002511|Radiation|low-LET photon therapy|
5819781|NCT00002490|Biological|BCG vaccine|
5819782|NCT00002490|Drug|mitomycin C|
5819783|NCT00002490|Radiation|radiation therapy|
5819784|NCT00002484|Radiation|radiation therapy|
5819785|NCT00002475|Biological|allogeneic tumor cell vaccine|
5819786|NCT00002475|Biological|autologous tumor cell vaccine|
5819787|NCT00002475|Biological|recombinant interferon alfa|
5819788|NCT00002475|Biological|recombinant interferon gamma|
5819789|NCT00002475|Biological|sargramostim|
5819790|NCT00002475|Drug|cyclophosphamide|
5819791|NCT00002474|Drug|carboplatin|
5819792|NCT00002474|Drug|cyclophosphamide|
5819793|NCT00002474|Drug|mitoxantrone hydrochloride|
5819794|NCT00002474|Procedure|autologous bone marrow transplantation|
5819795|NCT00002474|Procedure|bone marrow ablation with stem cell support|
5819796|NCT00002473|Procedure|conventional surgery|
5819797|NCT00002472|Drug|cisplatin|
5819798|NCT00002472|Drug|etoposide|
5819799|NCT00002472|Procedure|conventional surgery|
5819800|NCT00002472|Procedure|neoadjuvant therapy|
5819801|NCT00002472|Radiation|radiation therapy|
5819802|NCT00002470|Biological|recombinant interferon alfa|
5819803|NCT00002470|Drug|fluorouracil|
5819804|NCT00002455|Biological|Corynebacterium granulosum P40|
5819805|NCT00002455|Procedure|adjuvant therapy|
5819806|NCT00052156|Biological|CancerVax vaccine (CANVAXIN)|
5819807|NCT00052130|Biological|CancerVax vaccine (CANVAXIN)|
5819808|NCT00051818|Behavioral|Treatment interruption/reinitiation schedule|
5819809|NCT00052117|Drug|capravirine|
5819810|NCT00052117|Drug|Kaletra|
5819811|NCT00052117|Drug|2 NRTIs|
5819812|NCT00052104|Behavioral|Cognitive-Behavioral Family Systems Intervention|
5819813|NCT00052091|Behavioral|Problem Solving Therapy|A 12 week cognitive behavioral intervention for depression that teaches patients a structured approach to solving social problems.
5819814|NCT00052091|Behavioral|Brief Supportive Therapy|A 12 week intervention for depression that focuses on supporting patients attempts to cope with depression.
5819815|NCT00052078|Drug|Sertraline (SRT)|Participants were treated with sertraline.
5819816|NCT00052078|Behavioral|Cognitive Behavioral Therapy (CBT)|Participants received CBT.
5819817|NCT00052078|Drug|Placebo|Participants were treated with a placebo pill.
5819818|NCT00052065|Drug|TLK286|
5819819|NCT00052052|Drug|interferon-gamma 1b|200 mcg, SQ, 3x per week
5819820|NCT00052026|Drug|carvedilol|low-dose carvedilol administered twice daily for 8 months
5819821|NCT00052026|Drug|placebo|administered twice daily for 8 months
5819822|NCT00052026|Drug|carvedilol|high-dose carvedilol administered twice daily for 8 months
5819823|NCT00052039|Drug|interferon-gamma 1b|This study was terminated prior to enrollment.
5819824|NCT00052039|Drug|azathioprine|This study was terminated prior to enrollment.
5819825|NCT00052013|Drug|PTK787/ZK 222584|
5819826|NCT00052000|Drug|MLN2704 (DM1 conjugated monoclonal antibody MLN591)|
5819827|NCT00051987|Drug|VELCADE TM (bortezomib) for Injection, or PS-341|
5819828|NCT00051974|Drug|VELCADE™ (bortezomib) for Injection (formerly PS-341)|
5819829|NCT00051948|Drug|TLK286|
5819830|NCT00051935|Drug|Alglucosidase alfa|20 mg/kg (qow); intravenous
5819831|NCT00051922|Biological|PolyEnv1|Recombinant vaccinia virus vaccine
5819832|NCT00051909|Drug|LY451395|
5819833|NCT00051896|Drug|GBR 12909|
5819834|NCT00051844|Drug|Capravirine|
5819835|NCT00051831|Drug|Emtricitabine|Will be administered as one 200-mg capsule orally daily
5819836|NCT00051831|Drug|Enfuvirtide|Will be administered as a 90-mg (1.0 mL) subcutaneous injection twice daily
5819837|NCT00051831|Drug|Ritonavir|Will be administered as one 100-mg capsule orally twice daily
5819838|NCT00051831|Drug|Saquinavir|Will be administered as five hard gel capsules orally twice daily
5819839|NCT00051831|Drug|Tenofovir disoproxil fumarate|Will be administered as one 300-mg tablet orally daily
5819840|NCT00051870|Device|Magstim Rapid Magnetic Stimulator|
5819841|NCT00051805|Behavioral|Promotion of adherence to ARV medications|
5819842|NCT00051792|Behavioral|yoga|
5819843|NCT00051779|Drug|CAL|
5819844|NCT00051766|Behavioral|Computer-based Intervention|
5819845|NCT00051753|Drug|levofloxacin; amoxicillin/clavulanate|
5819846|NCT00051740|Behavioral|Cognitive Adaptation Therapy (CAT)|
5819847|NCT00051740|Behavioral|Minimal Environmental Supports (MES)|
5819848|NCT00051727|Behavioral|Bridges to High School Project|
5819849|NCT00051701|Drug|alemtuzumab|
5819850|NCT00051688|Drug|tezacitabine|
5819851|NCT00051688|Drug|oxaliplatin|
5819852|NCT00051675|Drug|ING-1(heMAb)|
5819853|NCT00051662|Drug|efalizumab|
5819854|NCT00051636|Drug|Zoledronic Acid|Zoledronic acid 5 mg in 5 mL of sterile water intravenous infusion.
5819855|NCT00051636|Drug|Risedronate|Oral risedronate 30 mg capsules.
5819856|NCT00051636|Drug|Placebo to Risedronate|Oral placebo of risedronate capsules.
5819857|NCT00051636|Drug|Placebo to Zoledronic Acid|5 mL of sterile water one dose intravenous infusion.
5819858|NCT00051636|Dietary Supplement|Calcium and Vitamin D|Calcium and vitamin D supplements were supplied.
5819859|NCT00051623|Drug|Infliximab|
5819860|NCT00051597|Drug|SGN-30 (monoclonal antibody)|
5819861|NCT00051584|Drug|SGN-15 (cBR96-Doxorubicin Immunoconjugate)|
5819862|NCT00051584|Drug|Gemzar (Gemcitabine)|
5819863|NCT00051571|Drug|SGN-15|
5819864|NCT00051571|Drug|Docetaxel|
5819865|NCT00051428|Procedure|Reiki (distant and direct-contact)|
5819866|NCT00051415|Behavioral|Flaxseed-supplemented diet|
5819867|NCT00051402|Drug|Isoflavones|
5819868|NCT00051558|Drug|Teriparatide|20 micrograms/day, injection, 36 months
5819869|NCT00051558|Drug|Alendronate Sodium|10 mg/day, oral, 36 months
5819870|NCT00051558|Drug|Placebo|Oral placebo, daily, 36 months
5819871|NCT00051558|Drug|Placebo|Injection placebo, daily, 36 months
5819872|NCT00051545|Drug|Seocalcitol|
5819873|NCT00051532|Drug|Seocalcitol|
5819874|NCT00051506|Drug|ALIMTA|
5819875|NCT00051506|Drug|carboplatin|
5819876|NCT00051506|Drug|cisplatin|
5819881|NCT00051454|Biological|HIV DNA plasmid vaccine plus recombinant fowlpox vector|
5819882|NCT00051441|Drug|Benzydamine Hydrochloride 0.15% Oral Rinse|
5819883|NCT00051389|Drug|Fosinopril|
5819884|NCT00051376|Drug|L-Arginine|
5819885|NCT00051363|Device|Active CPAP|Nightly nasal continuous positive airway pressure (CPAP)
5819886|NCT00051363|Device|Sham CPAP|Sham CPAP machine will be used for participants in the placebo group.
5819887|NCT00051350|Other|CARB|
5819888|NCT00051298|Drug|Olanzapine|
5819889|NCT00051298|Drug|Placebo|
5819890|NCT00051285|Drug|Enoximone|Participants receive oral enoximone
5819891|NCT00051285|Drug|Enoximone placebo|Participants receive placebo to match enoximone
5819892|NCT00051311|Procedure|Stem cell transplantation|
5819893|NCT00051272|Drug|Extended-release Bupropion Hydrochloride|
5819894|NCT00051259|Drug|Extended-Release Bupropion Hydrochloride|
5819895|NCT00051246|Behavioral|Mother-Infant Group Psychotherapy|Mother-infant group psychotherapy consists of weekly 2.5-hour psychotherapy sessions comprised of mother's group therapy, infant developmental therapy, and mother-infant dyadic psychotherapy. Group treatment will last 15 weeks.
5819896|NCT00051246|Behavioral|Interpersonal Psychotherapy|Individual psychotherapy treatment focuses on role transition, interpersonal relationships, and loss. Individual treatment period will last 15 weeks.
5819897|NCT00051233|Procedure|World Wide Web-Based Psychoeducation|
5819898|NCT00051220|Behavioral|One-Session Treatment for Specific Phobias|
5819899|NCT00051207|Behavioral|Interpersonal Psychotherapy (IPT)|
5819900|NCT00051207|Behavioral|IPT for Depression with Co-occurring Panic and Anxiety Symptoms (IPT-PS)|
5819901|NCT00051194|Drug|Combination IOP Lowering Therapy|
5819902|NCT00051181|Drug|Travoprost (0.004%)|
5819903|NCT00051181|Drug|Latanoprost (0.005%)|
5819904|NCT00051168|Drug|Travatan|Travoprost (0.004%) 1 drop each eye once daily
5819905|NCT00051155|Drug|Travoprost (0.004%)|
5819906|NCT00051155|Drug|Latanoprost (0.005%)/Timolol (0.5%)|
5819907|NCT00051142|Drug|Travoprost|
5819908|NCT00051142|Drug|Latanoprost|
5819909|NCT00051129|Drug|Anecortave Acetate 15 mg sterile suspension|0.5 ml of 30 mg/ml administered as a posterior juxtascleral injection
5819910|NCT00051129|Other|Anecortave Acetate Vehicle|Administered as a posterior juxtascleral injection
5819911|NCT00051116|Drug|CC-5013|
5819912|NCT00051103|Drug|Investigational Cancer Drug|
5819913|NCT00051090|Drug|Telbivudine|Administered orally at a daily dosage of 600 mg for a period of 48 weeks
5819914|NCT00051090|Drug|Lamivudine|Administered orally at a total daily dosage of 300 mg for Weeks 24-48
5819915|NCT00051090|Drug|Efavirenz|Administered orally at a daily dose of 600 mg
5819916|NCT00051090|Drug|Didanosine|Administered orally at a total dosage of either 400 mg or 250 mg determined by individual weight
5819917|NCT00051090|Drug|Abacavir|Administered orally twice daily in doses of 300 mg
5819918|NCT00051077|Drug|Adefovir dipivoxil|
5819919|NCT00051077|Drug|Peginterferon-alfa-2A|
5819920|NCT00051077|Drug|Ribavirin|
5819921|NCT00051077|Procedure|Liver Biopsy|
5819922|NCT00051051|Drug|CI-1033|
5819923|NCT00051038|Drug|Entecavir|
5819924|NCT00051025|Drug|ONTAK|
5819925|NCT00051012|Drug|ONTAK|
5819926|NCT00050999|Drug|ONTAK|
5819927|NCT00050986|Drug|Temozolomide|Starting Dose Level: 100 mg/m^2 taken by mouth once daily for 7 days, followed by 7 days rest and another 7-day dosing period and 7-day rest period.
5819928|NCT00050986|Drug|R115777|Starting Dose Level: 400 mg taken by mouth for 7 consecutive days every other week on alternating weeks (days 8-14 and 22-28) every 4 weeks.
5819929|NCT00050973|Drug|bexarotene|
5819930|NCT00050960|Drug|bexarotene with carboplatin and paclitaxel|bexarotene capsules (400 mg/m^2/day) in combination with carboplatin IV (AUC 6) every 3 weeks and paclitaxel IV (200 mg/m^2) every 3 weeks. Subjects in this group also received an antilipid agent which was selected at the discretion of the investigator.
5819931|NCT00050960|Drug|carboplatin and paclitaxel|carboplatin IV (AUC 6) every 3 weeks and paclitaxel IV (200 mg/m^2) every 3 weeks.
5819932|NCT00050947|Drug|oxcarbazepine|
5819933|NCT00050934|Drug|oxcarbazepine|
5819934|NCT00050921|Drug|somatropin|
5819935|NCT00050921|Biological|Hepatitis A virus, inactivated|
5819936|NCT00050921|Drug|Keyhole-Limpet Hemocyanin|
5819937|NCT00050895|Drug|Lopinavir/ritonavir|
5819938|NCT00050895|Drug|Efavirenz|
5819939|NCT00050895|Drug|Stavudine|
5819940|NCT00050895|Drug|Zidovudine|
5819941|NCT00050895|Drug|Lamivudine|
5819942|NCT00050895|Drug|Tenofovir disoproxil fumarate|
5819943|NCT00050882|Drug|GM-611|
5819944|NCT00050856|Drug|Enfuvirtide T/20/Ro 29,9800, HIV-1 Infusion Inhibitor|
5819945|NCT00050843|Drug|thalidomide|
5819946|NCT00050830|Drug|CI 1033|
5819947|NCT00050817|Drug|clopidogrel (SR25990)|
5819948|NCT00050791|Drug|Leptin|Leptin is an adipocyte hormone that functions as an afferent signal in a feedback loop regulating body weight
5819949|NCT00050791|Behavioral|Very Low Calorie Diet|placebo injections
5819950|NCT00050778|Biological|Interferon beta-1a|Interferon beta-1a 44 microgram (mcg) subcutaneously 3-times weekly for 36 months.
5819951|NCT00050778|Biological|Alemtuzumab 12 mg|Alemtuzumab 12 milligram per day (mg/day) was given by intravenous infusion on 5 consecutive days during the first month and on 3 consecutive days at months 12 and 24 (the latter at the treating physicians' discretion if the cluster of differentiation 4+ [CD4+] T-cell count was >=100*10^6 cells per liter).
5819952|NCT00050778|Biological|Alemtuzumab 24 mg|Alemtuzumab 24 mg/day was given by intravenous infusion on 5 consecutive days during the first month and on 3 consecutive days at months 12 and 24 (the latter at the treating physicians' discretion if the CD4+ T-cell count was >=100*10^6 cells per liter).
5819953|NCT00050804|Drug|sertraline|
5819954|NCT00050765|Drug|MyoCell™ Autologous Myoblasts|
5819955|NCT00050687|Drug|Gallium maltolate|
5819956|NCT00050726|Drug|Interleukin-2|
5819958|NCT00050674|Drug|Filgrastim-SD/01|6 mg SC on Day 9 (24 hours after the end of the chemotherapy infusion)
5819959|NCT00050661|Drug|Daclizumab|Humanized anti-CD25 antibodies (anti-TAC), or placebo (saline solution), will be given as intravenous infusions on the following schedule: 2 mg/kg initially (maximum dose 200 mg) infusion given over 60 minutes, followed by a 1 mg/kg (maximum of 100 mg) infusion given over 30 minutes every two weeks thereafter for a total of 8 doses.
5819960|NCT00050661|Device|NB-UVB|total body NB-UVB at a dose that is 50% of the MED. Patients are treated 3-7 times per week, with increasing doses at every treatment if no burning occurs. This is continued until for a total of 20 ± 2 treatments total.
5819961|NCT00050648|Drug|Daclizumab|1mg/kg medication every other week on the odd week (week 1-13).
5819962|NCT00050648|Drug|Cyclosporine|2mg/kg/day orally from Day 0 until Day 90 or a total of 13 weeks.
5819963|NCT00050648|Drug|cyclosporine and Daclizumab|1mg/kg plus low dose cyclosporine (2 mg/kg/day)
5819964|NCT00050635|Drug|Sandostatin LAR Depot|
5819965|NCT00050609|Drug|tadalafil|5 mg tadalafil tablet taken by mouth once a day for 8 weeks
5819966|NCT00050609|Drug|tadalafil|20 mg tadalafil tablet taken by mouth once a day for 8 weeks
5819967|NCT00050609|Drug|placebo|Placebo tablet taken by mouth once a day for 8 weeks
5819968|NCT00050427|Drug|ET743|580 mcg/m2, 3-hour i.v. infusion, on Days 1, 8, and 15 every 28 days for up to approximately 52 weeks in the absence of disease progression. Dexamethasone, 10 mg i.v, will be administered 30 minutes prior to each trabectedin infusion.
5819969|NCT00050427|Drug|ET743|1,300 mcg/m2, 3 hour i.v. infusion once every 21 days for up to approximately 52 weeks in the absence of disease progression. Dexamethasone, 10 mg i.v, will be administered 30 minutes prior to each trabectedin infusion.
5819970|NCT00050622|Drug|Methylphenidate 0.15 mg/kg|0.15 m/kg/dose immediate-release methylphenidate
5819971|NCT00050622|Behavioral|Low-Intensity BMOD|Lower-intensity behavioral treatment package.
5819972|NCT00050622|Drug|Methylphenidate 0.3 mg/kg|0.3 mg/kg/dose immediate-release methylphenidate
5819973|NCT00050622|Drug|Placebo|
5819974|NCT00050622|Drug|Methylphenidate 0.6 mg/kg|0.3 mg/kg/dose immediate-release methylphenidate
5819975|NCT00050622|Behavioral|High Intensity BMOD|Comprehensive high-intensity Summer Treatment Program (STP)
5819976|NCT00050596|Drug|MDX-010 / MDX-010 + Docetaxel|
5819977|NCT00050583|Behavioral|Cognitive Behavioral Therapy|Ten Weekly Sessions of Manualized CBT
5819978|NCT00050583|Behavioral|CBT|Cognitive Behavioral Therapy
5819979|NCT00050570|Behavioral|Web-based intervention to reduce eating disorder risk factors|
5819980|NCT00050557|Behavioral|Multifamily Psychoeducation Group (MFPG)|MFPG will include 8 weekly 90-minute group therapy sessions.
5819981|NCT00050557|Behavioral|Treatment as usual (TAU)|Participants will receive standard care for mood disorders.
5819982|NCT00050518|Biological|Aventis Pasteur Smallpox Vaccine|
5819983|NCT00050505|Biological|Live vaccinia virus vaccine|Dryvax undiluted. Cohort A receives undiluted dose of Dryvax vaccine
5819984|NCT00050505|Biological|Live vaccinia virus vaccine|Dryvax with diluent (50% glycerin and 0.25% phenol in sterile water). Cohort A-C receives diluted dose of Dryvax vaccine.
5819985|NCT00050479|Drug|Celecoxib (Celebrex)|
5819986|NCT00050440|Drug|Trabectedin|Trabectedin 1.3 mg/m2 administered intravenously every 21 days.
5819987|NCT00050440|Drug|Dexamethasone|Dexamethasone 4 mg administered orally (by mouth) the day before the trabectedin dose, 30 minutes before the trabectedin dose, and for 2 days following the trabectedin dose
5819988|NCT00050414|Drug|Trabectedin|Trabectedin 0.58 mg/m2, administered as a 3-hour intravenous infusion, Days 1, 8, and 15 every 28 days for up to approximately 3 years in the absence of disease progression.
5819989|NCT00050414|Drug|Dexamethasone|Dexamethasone 10 mg administered intravenously 30 minutes prior to each trabectedin infusion.
5819990|NCT00050401|Drug|MERREM I.V. 2g as a 3 hour infusion every 8 hours|
5819991|NCT00050401|Drug|vancomycin I.V. 1 g every 12 hours|
5819992|NCT00050401|Drug|tobramycin I.V. 5 mg/kg every 24 hours|
5819993|NCT00050401|Drug|MERREM I.V. 1g as a 30 minute infusion every 8 hours|
5819994|NCT00050401|Drug|MERREM I.V. 500 mg as a 3 hour infusion every 8 hours|
5819995|NCT00011635|Drug|Silymarin (milk thistle)|
5819996|NCT00011063|Drug|Ginkgo Biloba|
5819997|NCT00009542|Drug|kava (Piper methysticum)|
5819998|NCT00006395|Drug|St. John's Wort|
5819999|NCT00006155|Drug|SU5416 and carboplatin|
5820000|NCT00006062|Drug|oxaliplatin|
5820001|NCT00005926|Drug|Gemcitabine|
5820002|NCT00005926|Drug|Herceptin|
5820003|NCT00005926|Procedure|Radiation therapy|
5820004|NCT00005912|Drug|Voriconazole|
5820005|NCT00005783|Drug|Recombinant-methionyl human stem cell factor|
5820006|NCT00005574|Drug|Gentamicin|
5820007|NCT00004576|Drug|LY300164|
5820008|NCT00001986|Drug|1-Octanol|
5820009|NCT00001968|Drug|Amprenavir|
5820010|NCT00001968|Drug|Ritonavir|
5820011|NCT00001968|Drug|Abacavir|
5820012|NCT00001968|Drug|Lamivudine|
5820013|NCT00001966|Drug|Mind-body therapy|
5820014|NCT00001965|Drug|Cyclosporine A|
5820015|NCT00001963|Procedure|hemoglobin-transported nitric oxide|
5820016|NCT00001944|Drug|Vinorelbine|
5820017|NCT00001944|Drug|XR9576|
5820018|NCT00001940|Drug|Voriconazole|
5820019|NCT00001937|Drug|FK463|
5820020|NCT00001937|Drug|Fluconazole|
5820021|NCT00001931|Drug|N-0923|
5820022|NCT00001930|Drug|Amantadine|
5820023|NCT00001929|Drug|Eliprodil|
5820024|NCT00001909|Drug|Soluble recombinantly produced IL-4R|
5820025|NCT00001906|Biological|Combination of autoclaved leishmania antigen with recombinant human interleukin-12 (rhIL-12) and aluminum hydroxide gel as adjuvants|
5820026|NCT00001903|Drug|RSV Polyclonal Immunoglobulin|
5820027|NCT00001891|Procedure|Myocardial contrast echocardiography|
5820028|NCT00001891|Procedure|Dobutamine echocardiography|
5820029|NCT00001890|Drug|Estrogen therapy|
5820030|NCT00001889|Procedure|Myocardial contrast echocardiography|
5820031|NCT00001889|Procedure|Stress echocardiography with dobutamine|
5820032|NCT00001886|Procedure|Real time 3-dimensional stress echocardiography|
5820033|NCT00001857|Drug|BG9588|
5820034|NCT00001839|Drug|Antithymocyte globulin|
5820035|NCT00001839|Drug|Cyclosporine|
5820036|NCT00001812|Drug|Nystatin|
5820037|NCT00001810|Drug|Voriconazole|
5820038|NCT00001805|Drug|Rituximab|
5820039|NCT00001797|Drug|Recombinant human interleukin-10|
5820040|NCT00001790|Drug|FK463|
5820041|NCT00001789|Drug|BG9588|
5820042|NCT00001777|Drug|Sertraline|
5820043|NCT00001768|Drug|Intravenous immunoglobulin|
5820044|NCT00001763|Drug|Interleukin-12|
5820045|NCT00001761|Drug|Interleukin-10|
5820046|NCT00001757|Drug|Voriconazole|
5820047|NCT00001753|Procedure|Magnetic resonance imaging|
5820048|NCT00001752|Drug|L-arginine|
5820049|NCT00001752|Drug|Estrogen|
5820050|NCT00001748|Procedure|Peripheral blood progenitor cell transplant|
5820051|NCT00001736|Drug|Cysteamine|
5820052|NCT00001735|Procedure|Gene therapy|
5820053|NCT00001731|Drug|Cyclosporin A|
5820054|NCT00001730|Drug|Thyrogen|
5820055|NCT00001718|Device|Electropalatography|
5820056|NCT00001705|Drug|GP100 peptide|
5820057|NCT00001705|Drug|IL-2|
5820058|NCT00001696|Drug|Genistein|
5820059|NCT00001685|Biological|Immunodominant peptides from three melanoma antigens, MART-1, GP100 and tyrosinase|
5820060|NCT00001680|Drug|Thalidomide|
5820061|NCT00001677|Drug|Methotrexate|
5820062|NCT00001677|Drug|Fludarabine|
5820063|NCT00001669|Drug|rhIGF-1 (CEP-151)|
5820064|NCT00001658|Drug|Amoxicillin|
5820065|NCT00001646|Drug|Voriconazole|
5820066|NCT00001646|Drug|Amphotericin B|
5820067|NCT00001633|Procedure|Coronary magnetic resonance angiography imaging|
5820068|NCT00001629|Drug|Angiotensin II type 1 receptor antagonists|
5820069|NCT00001628|Drug|Angiotensin II type 1 receptor antagonists|
5820070|NCT00001624|Drug|Insulin|
5820071|NCT00001622|Procedure|investigate the relationship between in vivo and in vitro vascular responses|
5820072|NCT00001615|Drug|Corticosteroid|
5820073|NCT00001614|Drug|Chicken type II collagen|
5820074|NCT00001605|Biological|Nontypeable Haemophilus influenzae|
5820075|NCT00001587|Procedure|Isolated hepatic portal and arterial perfusion|
5820076|NCT00001587|Drug|Melphalan|
5820077|NCT00001579|Drug|5-Fluorouracil|
5820078|NCT00001579|Drug|Ethynyluracil|
5820079|NCT00001579|Drug|Leucovorin|
5820080|NCT00001577|Procedure|double isolated limb perfusion with melphalan alone|
5820081|NCT00001573|Drug|SU101|
5820082|NCT00001570|Drug|PSC 833|
5820083|NCT00001570|Drug|vinblastine|
5820084|NCT00001565|Drug|phenylbutyrate|
5820085|NCT00001554|Device|intraoperative infrared (IR) neuroimaging|
5820086|NCT00001538|Biological|APL 400-003|
5820087|NCT00001533|Drug|cyclosporine|
5820088|NCT00001520|Drug|neostigmine|
5820089|NCT00001509|Drug|IFN-alpha with retinoic acid|
5820090|NCT00001502|Drug|RMP-7 and carboplatin|
5820091|NCT00001499|Drug|paclitaxel|
5820092|NCT00001499|Drug|cisplatin|
5820093|NCT00001499|Procedure|chest radiotherapy|
5820094|NCT00001498|Drug|methotrexate|
5820095|NCT00001498|Drug|leucovorin|
5820096|NCT00001498|Drug|5-fluorouracil|
5820097|NCT00001498|Drug|cyclophosphamide|
5820098|NCT00001498|Procedure|peripheral blood progenitor cell|
5820099|NCT00001498|Drug|paclitaxel|
5820100|NCT00001498|Drug|doxorubicin|
5820101|NCT00001495|Drug|irinotecan (CPT-11)|
5820102|NCT00001493|Genetic|peripheral blood progenitor cells carrying MDR1|
5820103|NCT00001482|Drug|Lamotrigine (Lamictal® (Registered Trademark)|
5820104|NCT00001482|Drug|Gabapentin (Neurontin® (Registered Trademark))|
5820105|NCT00001450|Drug|paclitaxel|
5820106|NCT00001450|Drug|cisplatin|
5820107|NCT00001449|Drug|gemcitabine|
5820108|NCT00001449|Drug|fluorodeoxyuridine|
5820109|NCT00001449|Drug|leucovorin|
5820110|NCT00001446|Drug|thalidomide|
5820111|NCT00001445|Biological|HIV-1 Immunogen|
5820112|NCT00001443|Drug|indinavir (MK-0639)|
5820113|NCT00001439|Biological|gp100 human melanoma peptide|
5820114|NCT00001438|Drug|all-trans-retinoic acid with IFN-alpha2a|
5820115|NCT00001437|Drug|pentoxifylline|
5820116|NCT00001436|Drug|OncoLAR® (Registered Trademark)|
5820117|NCT00001436|Drug|tamoxifen|
5820118|NCT00001431|Drug|gemcitabine|
5820119|NCT00001428|Drug|5-fluorouracil|
5820120|NCT00001427|Drug|9-aminocamptothecin|
5820121|NCT00001422|Drug|fludarabine|
5820122|NCT00001421|Drug|methimazole|
5820123|NCT00001416|Drug|CEREDASE™|
5820124|NCT00001402|Device|PET scan|
5820125|NCT00001387|Drug|paclitaxel|
5820126|NCT00001384|Drug|Adriamycin|
5820127|NCT00001384|Drug|cyclophosphamide|
5820128|NCT00001384|Drug|G-CSF|
5820129|NCT00001384|Drug|paclitaxel|
5820130|NCT00001383|Drug|PSC 833|
5820131|NCT00001383|Drug|paclitaxel|
5820132|NCT00001382|Biological|PROSTVAC|
5820133|NCT00001381|Drug|suramin|
5820134|NCT00001378|Drug|fenretinide|
5820135|NCT00001365|Drug|dextromethorphan|
5820136|NCT00001344|Drug|dextromethorphan|
5820137|NCT00001341|Drug|ZD1694 (TOMUDEX)|
5820138|NCT00001338|Drug|FLAC chemotherapy with GM-CSF|
5820139|NCT00001333|Drug|topotecan|
5820140|NCT00001332|Procedure|CHPP with cisplatin|
5820141|NCT00001318|Drug|interferon gamma|
5820142|NCT00001317|Drug|interferon-gamma|
5820143|NCT00001311|Device|heparin-surface modified intraocular lens|
5820144|NCT00001300|Drug|doxorubicin|
5820145|NCT00001300|Drug|ifosfamide|
5820146|NCT00001300|Drug|mesna|
5820147|NCT00001298|Drug|carboxypeptidase-G2|
5820148|NCT00001296|Drug|melphalan|
5820149|NCT00001296|Drug|tumor necrosis factor|
5820150|NCT00001296|Drug|interferon-gamma|
5820151|NCT00001296|Procedure|hyperthermic isolated limb perfusion|
5820152|NCT00001287|Drug|intravenous immunoglobulin (IVIg)|
5820153|NCT00001280|Drug|itraconazole|
5820154|NCT00001272|Drug|taxol|
5820155|NCT00001271|Drug|IgG-RFB4-SMPT-dgA|
5820156|NCT00001270|Drug|interleukin-1|
5820157|NCT00001269|Drug|IL-3|
5820158|NCT00001267|Drug|zidovudine|
5820159|NCT00001267|Drug|2',3'-dideoxyinosine|
5820160|NCT00001249|Drug|Yttrium-90 radiolabeled anti-Tac antibody|
5820161|NCT00001239|Drug|FLAC with GM-CSF|
5820162|NCT00001237|Drug|granulocyte-macrophage colony stimulating factor (GM-CSF)|
5820163|NCT00001217|Drug|pre-surgical chemotherapy|
5820164|NCT00001209|Drug|vincristine, adriamycin and cytoxan, alternating with ifosfamide VP-16|
5820165|NCT00001193|Procedure|high dose melphalan and autologous bone marrow transplantation|
5820166|NCT00001189|Procedure|radiotherapy|
5820167|NCT00001188|Procedure|radiation therapy following surgery|
5820168|NCT00050388|Genetic|Allovectin-7®|
5820169|NCT00050375|Drug|oregovomab|
5820170|NCT00050362|Drug|Rofecoxib and Bupivacaine|
5820171|NCT00050349|Drug|EPO906 epothilone B|
5820172|NCT00050336|Drug|Lonafarnib (SARASAR)|
5820173|NCT00050323|Drug|Allogeneic DCs and Autologous RCC Tumor Derived Cells|
5820174|NCT00050297|Drug|YM598|
5820175|NCT00050271|Drug|Acetyl-L-carnitine|
5820176|NCT00050245|Drug|Rituximab|
5820177|NCT00050232|Drug|AVP-923|
5820178|NCT00050141|Drug|ZARNESTRA, tipifarnib, R115777|
5820179|NCT00050206|Drug|Olanzapine|
5820180|NCT00050206|Drug|Placebo|
5820181|NCT00050167|Drug|Paclitaxel|80 mg/m^2 by vein (IV) Weekly Over 1 Hour x 12 Weeks
5820182|NCT00050167|Drug|Docetaxel|75 mg/m^2 by vein (IV) Over 1 Hour Once Every 3 Weeks
5820183|NCT00050167|Drug|Capecitabine|1500 mg/m^2 by mouth Twice Daily x 2 Weeks
5820184|NCT00050180|Drug|Midazolam|
5820185|NCT00050180|Drug|Indinavir|
5820186|NCT00050180|Drug|Saquinavir|
5820187|NCT00050154|Drug|ZARNESTRA, tipifarnib, R115777|
5820188|NCT00050128|Device|rTMS, Magstim|
5820189|NCT00050102|Drug|MDX-010 (CTLA-4)|
5820190|NCT00050089|Other|No Antiretroviral Drug-Free Period (No ARDFP) vs ARDFP|Continuation or interruption of ART treatment
5820191|NCT00050089|Drug|Standard ART vs Mega ART|Standard therapy vs Intensified therapy
5820192|NCT00050089|Other|No Antiretroviral Drug-Free Period (No ARDFP) vs ARDFP|Continuation or interruption of ART treatment
5820193|NCT00050089|Drug|Standard ART vs Mega ART|Standard therapy vs Intensified therapy
5820194|NCT00050089|Other|No Antiretroviral Drug-Free Period (No ARDFP) vs ARDFP|Continuation or interruption of ART treatment
5820195|NCT00050089|Drug|Standard ART vs Mega ART|Standard therapy vs Intensified therapy
5820196|NCT00050089|Other|No Antiretroviral Drug-Free Period (No ARDFP) vs ARDFP|Continuation or interruption of ART treatment
5820197|NCT00050089|Drug|Standard ART vs Mega ART|Standard therapy vs Intensified therapy
5820198|NCT00050076|Drug|MCC-135|MCC-135 50 mg, tablets, orally, twice daily for up to 12 weeks
5820199|NCT00050076|Drug|MCC-135|MCC-135 100 mg, tablets, orally, once daily for up to 12 weeks
5820200|NCT00050076|Drug|MCC-135|MCC-135 200 mg, tablets, orally, once daily for up to 12 weeks
5820201|NCT00050076|Drug|Placebo|MCC-135 placebo-matching tablets, orally, once daily for up to 12 weeks
5820202|NCT00050063|Biological|Therapeutic vaccinations from A5058s|Participants will receive assigned interventions assigned in study A5058s.
5820203|NCT00050050|Behavioral|Cognitive behavioral therapy|
5820204|NCT00050050|Drug|Drug therapy|
5820205|NCT00050037|Procedure|CBT|
5820206|NCT00050011|Drug|Zoledronic Acid|Participants received Zoledronate 4 mg IV 15-minute infusion every 6 months.
5820207|NCT00050011|Drug|Letrozole|Participants received Letrozole 2.5 mg daily.
5820208|NCT00049998|Drug|topotecan|
5820209|NCT00049985|Drug|Darbepoetin Alfa|
5820210|NCT00049972|Drug|paroxetine CR|
5820211|NCT00049959|Drug|verteporfin PDT|
5820212|NCT00049946|Drug|talnetant|
5820213|NCT00049946|Drug|risperidone|
5820214|NCT00049842|Biological|peginterferon alfa-2b (SCH 54031)|0.5 µg/kg Weekly QW SC for 36 months
5820215|NCT00049829|Drug|Zoledronic Acid|
5820216|NCT00049816|Behavioral|Walking exercise|30 minutes/day, 3 times/week for 52 weeks
5820217|NCT00049816|Behavioral|Cycling Exercise|30 minutes/day, 3 times/week for 52 weeks
5820218|NCT00049803|Drug|sodium oxybate|
5820219|NCT00049790|Drug|recombinant human Angiostatin protein|
5820220|NCT00049790|Drug|paclitaxel|
5820221|NCT00049790|Drug|carboplatin|
5820222|NCT00049777|Drug|Drotrecogin Alfa (Activated)|
5820223|NCT00049777|Drug|Unfractionated heparin|
5820224|NCT00049777|Drug|Low molecular weight heparin|
5820225|NCT00049764|Drug|Drotrecogin alfa (activated)|
5820226|NCT00049764|Drug|Placebo|
5820227|NCT00049751|Drug|Adalimumab|
5820228|NCT00048945|Drug|PEGASYS|
5820229|NCT00049725|Drug|Daclizumab|
5820230|NCT00048932|Drug|Double-blind Abatacept|Concentrate and diluted in a solution, IV, 500 mg (body weight < 60 Kg); 750 mg (body weight 60-100 Kg); 1000 mg (body weight > 100 Kg), Once daily, Day 1, 15, and 29.
5820231|NCT00048932|Drug|Double-blind Placebo|Concentrate and diluted in a solution, IV, 0 mg, Once daily, Day 1, 15, and 29.
5820232|NCT00048932|Drug|Open-label Abatacept|Concentrate and diluted in a solution, IV, 500 mg (body weight < 60 Kg); 750 mg (body weight 60-100 Kg); 1000 mg (body weight > 100 Kg), Once daily, Every 28 days.
5820233|NCT00048854|Drug|Sertraline|Patients who meet study criteria will be given 50 mg per day of sertraline to be taken an estimated 2 weeks before menstruation.
5820234|NCT00048854|Other|Treatment as usual (TAU)|At the TAU baseline visit, patients will be told of their diagnosis of PMS/PMDD. Those patients who decide to seek treatment outside of the study protocol or do not wish to seek treatment will be asked to participate in the TAU part of this protocol. Patients in TAU will be contacted monthly to obtain monthly information about how they have been feeling (blinded ratings) using the study measures.
5820235|NCT00048841|Drug|alendronate|
5820236|NCT00048828|Drug|Olanzapine|Participants will receive olanzapine for 12 weeks.
5820237|NCT00048828|Drug|Clozapine|Participants will receive 12 weeks of clozapine.
5820238|NCT00048815|Drug|Citalopram|Established Selective Serotonin Reuptake Inhibitor antidepressant
5820239|NCT00048815|Drug|St. John's Wort|Natural extract from the St. John's Wort plant.
5820240|NCT00048815|Drug|Placebos|Placebo pill
5820241|NCT00048802|Drug|Lithium|
5820242|NCT00048802|Drug|Olanzapine|
5820243|NCT00048802|Drug|Divalproex|
5820244|NCT00048802|Drug|Risperidone|
5820245|NCT00048802|Drug|Quetiapine|
5820246|NCT00048802|Drug|Ziprasidone|
5820247|NCT00048802|Drug|Aripriprazole|
5820248|NCT00048581|Drug|Abatacept|Vials, intravenous (IV), ~10mg/kg abatacept, One every 2 weeks for first month then every 4 weeks thereafter, 6 months.
5820249|NCT00048581|Drug|Placebo|Vials, IV, 0mg, One every 2 weeks for first month then every 4 weeks thereafter, 6 months.
5820250|NCT00048581|Drug|Abatacept|Vials, IV, ~10mg/kg abatacept, every 4 weeks, 5.5 years
5820251|NCT00048568|Drug|Abatacept|Intravenous (IV) Solution, - Weight Titered (500 mg < 60 kg); (750 mg 60-100 kg), )1 gram > 100 kg), Day 1, Day 15, Day 29; every 28 days thereafter, 1 year
5820252|NCT00048568|Drug|Methotrexate|Tablets, Oral, >= 15 mg, weekly, 1 year
5820253|NCT00048568|Drug|Placebo|IV solution, Intravenous, D5W, Day 1, Day 15, Day 29; every 28 days thereafter, 1 year
5820254|NCT00048906|Drug|DRX005B|
5820255|NCT00048893|Biological|recombinant fowlpox-CEA(6D)/TRICOM vaccine|4 x 10^8 pfu given monthly subcutaneously for three doses in the first series and three doses on each of the intermediate and late re-immunizations (total 9 doses).
5820256|NCT00048893|Biological|recombinant vaccinia-CEA(6D)/TRICOM vaccine|rV-CEA (6D)/Tricom concomitantly with sargramostim (rGM-CSF). 1.2 x 10^8 pfu x 1 dose subcutaneously.
5820257|NCT00048893|Biological|filgrastim|5 mcg/kg/day subcutaneously
5820258|NCT00048893|Biological|sargramostim|100 mcg daily for 4 consecutive days at the same site as the rF-CEA (6D)/Tricom vaccine. The first dose will be given with the vaccine.
5820259|NCT00048893|Drug|cyclophosphamide|"First induction chemotherapy: 2700 mg/m^2 per cycle (900 mg/m^2 per day intravenous over 1 hour for 3 consecutive days, days 1-3).~Second induction: 600 mg/m^2 per cycle (600 mg/m^2 intravenous over 1 hour day 1.~Immune depleting chemotherapy: 2400 mg/m^2 per cycle (600 mg/m^2 per day intravenous over 1 hour for 4 consecutive days, days 1-4)."
5820260|NCT00048893|Drug|doxorubicin hydrochloride|60 mg/m^2 per cycle (60 mg/m^2 slow intravenous push day 1).
5820261|NCT00048893|Drug|fludarabine phosphate|120 mg/m^2 (30 mg/m^2 per day intravenous over 30 minutes for 4 consecutive days (days 1-4)).
5820262|NCT00048893|Drug|paclitaxel|160 mg/m^2 per cycle (53.3 mg/m^2 per day by continuous intravenous infusion over 24 hours for 3 consecutive days 1-3).
5820263|NCT00048893|Drug|Mesna|"Percent equals fraction of total daily cyclophosphamide dose. Initial: 20% of cyclophosphamide dose given intravenously (IV) mixed with cyclophosphamide.~3 hours post completion of cyclophosphamide: 20% intravenously (IV) or 40% by mouth (PO) 6 hours post completion of cyclophosphamide: 20% intravenously (IV) or 40% by mouth (PO) 9 hours post completion of cyclophosphamide: 20% intravenously (IV) or 40% by mouth (PO)"
5820264|NCT00048880|Drug|HeFi-1 Monoclonal Antibody|
5820265|NCT00048776|Drug|Pletal|
5820266|NCT00048763|Drug|Pletal|
5820267|NCT00048789|Procedure|Extracorporeal Photopheresis|
5820268|NCT00048750|Drug|Micafungin|IV
5820269|NCT00048750|Drug|Placebo|IV
5820270|NCT00048737|Drug|Zevalin Radioimmunotherapy|Escalating single dose of 90Y Zevalin 0.2-0.3-0.4 mCi/kg
5820271|NCT00048737|Drug|Rituximab|250 mg/m^2 on day 1 and day 8
5820272|NCT00048737|Drug|Fludarabine|30 mg/m^2/day for 3 days
5820273|NCT00048737|Drug|Cyclophosphamide|750 mg/m^2/day for 3 days, given on the same days as fludarabine, at 4-hour intervals
5820274|NCT00048737|Procedure|Allogeneic Stem Cell Transplantation|Allogeneic stem cell transplantation 2 days after chemotherapy
5820275|NCT00048724|Biological|peginterferon alfa-2b (SCH 54031)|0.5 µg/kg subcutaneously once weekly for 60 months
5820276|NCT00048711|Drug|N-acetylgalactosamine 4-sulfatase|
5820277|NCT00048698|Procedure|TMS|
5820278|NCT00048698|Procedure|EEG|
5820279|NCT00048672|Drug|Gleevec|Starting dose of 400 mg orally daily.
5820280|NCT00048659|Drug|YM598|
5820281|NCT00048646|Drug|IV Progesterone|
5820282|NCT00048633|Drug|Chemotherapy|
5820283|NCT00048620|Drug|N-acetylgalactosamine 4-sulfatase|
5820284|NCT00048607|Drug|aprepitant|
5820285|NCT00048607|Drug|Comparator: paroxetine HCL|
5820286|NCT00048607|Drug|Comparator: Placebo (Unspecified)|
5820287|NCT00048594|Drug|aprepitant|
5820288|NCT00048594|Drug|Comparator: placebo (unspecified)|
5820289|NCT00048555|Drug|IDEC-114|Dose Group 1 - 125 mg/m2 x 4 infusions & 375 mg/m2 Rituxan x 4 infusions Dose Group 2 - 250 mg/m2 x 4 infusions & 375 mg/m2 Rituxan x 4 infusions Dose Group 3 - 375 mg/m2 x 4 infusions & 375 mg/m2 Rituxan x 4 infusions Dose Group 4 - 500 mg/m2 x 4 infusions & 375 mg/m2 Rituxan x 4 infusions
5820290|NCT00048542|Biological|Double-Blind Adalimumab/Placebo + MTX|Subcutaneous injection of 24 mg adalimumab or placebo per square meter of body surface area (BSA) every other week (eow) concomitantly with MTX treatment for 32 weeks during the Double-Blind phase. Total body dose of adalimumab was not to exceed 40 mg.
5820291|NCT00048542|Biological|Double-Blind Adalimumab/Placebo|Subcutaneous injection of 24 mg adalimumab or placebo per square meter of body surface area (BSA) every other week (eow) without MTX treatment for 32 weeks during the Double-Blind Phase. Total body dose of adalimumab was not to exceed 40 mg.
5822966|NCT00002065|Drug|Disulfiram|
5820292|NCT00048542|Drug|OLE BSA Adalimumab +/- MTX|Comparison of subcutaneous injection of 24 mg adalimumab per square meter of body surface area (BSA) every other week (eow) either with or without concomitant MTX treatment for a minimum of 44 weeks (up to a maximum of 136 weeks) during the Open-Label Extension BSA Phase.
5820293|NCT00048542|Drug|OLE FD Adalimumab +/- MTX|Comparison of adalimumab administered subcutaneously every other week (eow) either with or without concomitant MTX treatment for up to 224 weeks during the Open-Label Extension Fixed Dose (FD) Phase.
5820294|NCT00048529|Drug|T900607-sodium intravenous|
5820295|NCT00048516|Drug|paricalcitol capsule|
5820296|NCT00048503|Drug|ZARNESTRA, tipifarnib, R115777|
5820297|NCT00048464|Procedure|Infusion of Activated & Expanded Autologous T Cells|
5820298|NCT00048451|Drug|paricalcitol|
5820299|NCT00048438|Drug|paricalcitol|
5820300|NCT00048425|Drug|Levosimendan|
5820301|NCT00048490|Device|transcranial magnetic stimulation (TMS)|
5820302|NCT00048477|Drug|L-NMMA and Sodium Nitrite|
5820303|NCT00048412|Drug|FLUDARABINE|
5820304|NCT00048412|Drug|CAMPATH 1H|
5820305|NCT00048412|Drug|FK50|
5820306|NCT00048412|Procedure|Stem Cell Collection and Infusion|
5820307|NCT00048399|Drug|Fludarabine|
5820308|NCT00048399|Drug|CAMPATH 1H|
5820309|NCT00048399|Drug|FK506|
5820310|NCT00048399|Procedure|Stem Cell Transplantation|
5820311|NCT00048386|Biological|autologous neuroblastoma vaccine|A vaccine dose of 0.3 x 108 IL-2 secreting cells/patient/injection will be used. Injections will be given twice monthly for two months, then monthly for four months, for a total of eight vaccine injections over six months.
5820312|NCT00048373|Drug|Etanercept|
5820313|NCT00048360|Drug|Extended-release bupropion hydrochloride|
5820314|NCT00048321|Drug|ISIS 104838|
5820315|NCT00048308|Drug|pexelizumab|
5820316|NCT00048347|Drug|AVONEX|30µg IM every week for 12 weeks
5820317|NCT00048334|Drug|Depsipeptide, FR901228, FK228|
5820318|NCT00048295|Drug|Alicaforsen|
5820319|NCT00048230|Drug|bortezomib|
5820320|NCT00048217|Drug|T-1249|
5820321|NCT00048204|Drug|GW597599B|
5820322|NCT00048204|Drug|paroxetine|
5820323|NCT00048165|Drug|Daclizumab|Daclizumab will be administered as 1 mg/kg IV within 12 hours post-op (Day 1), and Days 8, 22, 36 and 50.
5820324|NCT00048165|Drug|Methylprednisolone|Methylprednisolone will be administered as 500-1000 mg IV and peri-operative switch to oral at 0.5-1 mg/kg/day followed by tapering till 0.0-0.15 mg/kg/day (up to 365 days).
5820325|NCT00048165|Drug|Mycophenolate mofetil|Mycophenolate mofetil will be administered as 1.5 grams bid begun post-op, either IV or orally as required up to 365 days.
5820326|NCT00048165|Drug|Placebo|Matching placebo will be administered on Days 1, 8, 22, 36, and 50.
5820327|NCT00048165|Drug|cyclosporine|Cyclosporine will be administered as 1-4 mg/kg IV or 2-6 mg/kg orally up to 365 days.
5820328|NCT00048152|Drug|Corticosteroids|As prescribed
5820329|NCT00048152|Drug|Neoral|Low dose (target trough level 50-100ng/mL)
5820330|NCT00048152|Drug|Neoral|Standard dose (target trough level 150-300ng/mL)
5820331|NCT00048152|Drug|Zenapax|2mg/kg iv first dose, then 1mg/kg every 2 weeks
5820332|NCT00048152|Drug|mycophenolate mofetil [CellCept]|1g po bid
5820333|NCT00048139|Drug|Irinotecan|250mg/m2 iv on day 1 of each 3 week cycle
5820334|NCT00048139|Drug|capecitabine [Xeloda]|1000mg/m2 po bid on days 1-15 of each 3 week cycle
5820335|NCT00048126|Drug|Irinotecan|100mg/m2 iv on days 1, 8, 15 and 22 of each 6 week cycle.
5820336|NCT00048126|Drug|capecitabine [Xeloda]|1000mg po bid
5820337|NCT00048113|Drug|Alicaforsen|
5820338|NCT00048100|Procedure|Apheresis|Apheresis for T-Cell collection
5820339|NCT00048100|Biological|Stem Cell Transplant|Stem cell or marrow infusions of allogeneic donor lymphocytes activated by acute leukemia derived dendritic cells (DC/ADL).
5820340|NCT00048087|Drug|ZD1839|250 mg by mouth daily each day for 4 weeks.
5820341|NCT00048087|Drug|Docetaxel|30 mg/m2 by IV on day 1 weekly for the first 3 weeks of each 4 week course.
5820342|NCT00048074|Drug|ibandronate [Bonviva/Boniva]|2mg iv every 2 months
5820343|NCT00048074|Drug|ibandronate [Bonviva/Boniva]|2.5mg po daily
5820344|NCT00048074|Drug|ibandronate [Bonviva/Boniva]|3mg iv every 3 months
5820345|NCT00048061|Drug|Ibandronate [Bonviva/Boniva]|2.5mg po daily
5820346|NCT00048061|Drug|Ibandronate [Bonviva/Boniva]|100mg po monthly on a single day
5820347|NCT00048061|Drug|Ibandronate [Bonviva/Boniva]|100mg po monthly over 2 consecutive days
5820348|NCT00048061|Drug|Ibandronate [Bonviva/Boniva]|150mg po monthly
5820349|NCT00048061|Dietary Supplement|Calcium|500 mg/day
5820350|NCT00048061|Dietary Supplement|Vitamin D|400 IU/day
5820351|NCT00048048|Drug|methoxy polyethylene glycol-epoetin beta [Mircera]|Differing doses and frequencies of sc administration
5820352|NCT00048035|Drug|methoxy polyethylene glycol-epoetin beta [Mircera]|Differing doses and frequencies of iv administration
5820353|NCT00048022|Drug|Dual Integrin Antagonist|
5820354|NCT00048009|Drug|Dual Integrin Antagonist|
5820355|NCT00047983|Dietary Supplement|Canola oil|
5820356|NCT00047983|Dietary Supplement|Arginine|
5820357|NCT00047983|Dietary Supplement|Fish oil emulsion|
5820358|NCT00047840|Drug|ZD6474|
5820359|NCT00047840|Drug|Placebo|
5820360|NCT00047840|Drug|Docetaxel|
5820361|NCT00047827|Drug|Micafungin|IV
5820362|NCT00047827|Drug|Liposomal Amphotericin B|IV
5820363|NCT00047814|Drug|FK788|
5820364|NCT00047931|Drug|VRC-HIVDNA009-00-VP|
5820365|NCT00047905|Behavioral|examine the process of prenatal genetic counseling|
5820366|NCT00047879|Biological|PEG-interferon alfa-2b|0.3 µg/kg of IFN alfa-2b (PEG-Intron once weekly) plus daily oral thalidomide, subcutaneous injection
5820367|NCT00047879|Drug|Thalidomide|Two 50mg tablets (100 mg total dose) every night before bedtime starting on day one.
5820368|NCT00047853|Device|Shock device|Electric shock stimulus
5820369|NCT00047853|Device|Acoustic startle|Acoustic startle for MEG only
5820370|NCT00047801|Drug|TLK286 in combination with docetaxel|
5820371|NCT00047788|Drug|ZD6474|
5820372|NCT00047788|Drug|VEGF-receptor tyrosine kinase (KDR)|
5820373|NCT00047775|Drug|BiDil|
5820374|NCT00047762|Drug|Erlotinib (aka Tarceva or OSI-774)|
5820375|NCT00047762|Drug|Bevacizumab (aka Avastin or Rhu MAb VEGF)|
5820376|NCT00047554|Drug|Travoprost, 0.004% ophthalmic solution|
5820377|NCT00047541|Drug|Alcon Investigational Agent|
5820378|NCT00047528|Drug|Alcon Investigational Agent|
5820379|NCT00047515|Drug|Alcon Investigational Agent|
5820380|NCT00047749|Drug|Prialt (ziconotide)|
5820381|NCT00047736|Drug|Tarceva (erlotinib HCl)|
5820382|NCT00047723|Drug|minocycline|
5820383|NCT00047710|Drug|Bevacizumab|Beginning 2 weeks prior to radiotherapy, dose of 5 mg/kg by vein then of 2.5 mg/kg during radiotherapy for four weeks every 2 weeks (three doses).
5820384|NCT00047710|Drug|Capecitabine|650mg/m^2 taken by mouth twice a day 15-52 during the radiotherapy.
5820385|NCT00047710|Radiation|Radiotherapy|Radiography given once a day for 5 days at 50.4 Gy in 28 fractions over 5.5 weeks.
5820386|NCT00047697|Drug|Donepezil HCl|Participants will start with 5 mg per day dose of donepezil HCl, then have their dose increased to 10mg per day after 4 weeks.
5820387|NCT00047697|Drug|Placebo|Placebo used in placed of Donepezil HCL
5820388|NCT00047684|Behavioral|Brief Integrative Therapy|
5820389|NCT00047671|Drug|Citalopram|PDA Approved antidepressant
5820390|NCT00047658|Drug|Interferon-gamma 1b|200 mcg, SQ, 3x per week
5820391|NCT00047645|Drug|Interferon-gamma 1b|200 mcg, SQ, 3x per week
5820392|NCT00047632|Drug|Interferon gamma-1b|100 mcg, SQ, 3x per week
5820393|NCT00047606|Drug|IOP Lowering Medications|
5820394|NCT00047593|Drug|IOP Lowering Medications|
5820395|NCT00047619|Procedure|Pulsatile Lavage|pulsatile lavage to wound bed
5820396|NCT00047619|Other|sham pulsatile lavage|pulsatile lavage to not directed at wound or patient
5820397|NCT00047580|Drug|tizanidine hydrochloride capsule|
5820398|NCT00047567|Drug|zonisamide|
5820399|NCT00046371|Drug|THERATOPE® vaccine|
5820400|NCT00047502|Drug|Lonafarnib (SCH66336)|"Participants in CHRONIC PHASE receive Gleevec 400 mg by mouth every day, and SCH66336 100 mg by mouth twice a day.~Participants in ACCELERATED OR BLASTIC PHASE receive SCH66336 100 mg by mouth twice a day.~Participants in ACCELERATED OR BLASTIC PHASE receive SCH66336 100 mg by mouth twice a day."
5820401|NCT00047502|Drug|Imatinib Mesylate (Gleevec)|"Participants in CHRONIC PHASE receive Gleevec 400 mg by mouth every day.~Participants in ACCELERATED OR BLASTIC PHASE receive Gleevec 600 mg by mouth every day."
5820402|NCT00047489|Drug|ABT-751|
5820403|NCT00047476|Drug|dexmethylphenidate(d-mph)|
5820404|NCT00047463|Device|continuous positive airway pressure (CPAP)|a mask treatment for sleep apnea
5820405|NCT00047463|Device|Placebo-CPAP|Placebo-CPAP
5820406|NCT00047450|Drug|Citalopram (Celexa)|Citalopram for 3 months
5820407|NCT00047450|Drug|Placebo|Placebo for 3 months
5820408|NCT00047437|Behavioral|Supervised Exercise Training Program|Exercise 30 minutes minimum three times per week.
5820409|NCT00047424|Drug|simvastatin|
5820410|NCT00047424|Drug|ACE inhibitors|
5820411|NCT00047411|Other|Cardiopulmonary Resuscitation|Immediate notification of EMS by telephone and prompt initiation of CPR, in accordance with published Basic Life Support guidelines
5820412|NCT00047411|Device|Automatic External Defibrillation|Use the AED first, in accordance with published guidelines for AED use, followed by a call to EMS and perform CPR as in the control group.
5820413|NCT00046800|Drug|OSI-211 (Liposomal Lurtotecan)|
5820414|NCT00046787|Drug|OSI-211 (Liposomal Lurtotecan)|
5820415|NCT00046761|Drug|ONO-2506|
5820416|NCT00046748|Drug|Omalizumab|
5820417|NCT00046813|Drug|Nicotine patch|
5820418|NCT00046774|Drug|MRA 003 US|
5820419|NCT00046735|Drug|Lenalidomide|The planned doses for investigation are as follows: 5, 10, and 25 mg/day. Lenalidomide will be administered as a single daily dose for 4 weeks followed by a 2-week rest period. Dosing will be in the morning at approximately the same time each day, at least 1 hour before the morning meal. Patients will be assigned to dose level in the order of study entry. No dose adjustments or suspensions are allowed during the first cycle, except discontinuation for DLT
5820420|NCT00046722|Drug|Smoked Marijuana|
5820421|NCT00046527|Drug|ABI-007|
5820422|NCT00046514|Drug|ABI-007|
5820423|NCT00046423|Drug|ABI-007|
5820424|NCT00046709|Drug|Smoked Marijuana|
5820425|NCT00046696|Drug|NM-3|
5820426|NCT00046683|Drug|alemtuzumab|
5820427|NCT00046540|Drug|Liposome-encapsulated SN38|
5820428|NCT00046501|Drug|Lantus (insulin glargine [rDNA origin] injection)|
5820429|NCT00046501|Drug|Humulin N|
5820430|NCT00046501|Drug|Humulin L|
5820431|NCT00046501|Drug|Lispro|
5820432|NCT00046488|Drug|IDEC-152|6 Dosing groups: 125mg/m2 weekly x 4, 250mg/m2 weekly x 4, 375mg/m2 weekly x 4, 500mg/m2 weekly x 4, 500mg/m2 3 times first week then weekly x 3, 500mg/m2 3 times per week x 4
5820433|NCT00046475|Drug|Midodrine Hydrochloride|
5820434|NCT00046462|Drug|Lantus (insulin glargine [rDNA origin] injection)|
5820435|NCT00046462|Drug|Metformin|
5820436|NCT00046462|Drug|Glyburide|
5820437|NCT00046462|Drug|Thiazolidinedione|
5820438|NCT00046449|Drug|Investigational Seasonal Affective Disorder (SAD) Drug|
5820439|NCT00046566|Dietary Supplement|Soy protein-milk protein-carbohydrate|40 grams of soy protein per day for 8 weeks, 40 grams of milk protein per day for 8 weeks, and 40 grams of carbohydrate per day for 8 weeks
5820440|NCT00046566|Dietary Supplement|Milk protein-carbohydrate-soy protein|40 grams of milk protein per day for 8 weeks, 40 grams of carbohydrate per day for 8 weeks, 40 grams of soy protein per day for 8 weeks.
5820441|NCT00046566|Behavioral|Carbohydrate-soy protein-milk protein|40 grams of carbohydrate per day for 8 weeks, 40 grams of soy protein per day for 8 weeks, 40 grams of milk protein per day for 8 weeks,
5820442|NCT00046553|Drug|RU-486 (Mifepristone)|
5820443|NCT00046384|Drug|aripiprazole|
5820444|NCT00046397|Drug|Modified Vaccinia Virus Ankara TBC-M|
5820445|NCT00046345|Drug|Atazanavir (BMS-232632)|
5820446|NCT00046332|Drug|GW810781|
5820447|NCT00046319|Drug|BSF 208075|
5820448|NCT00046306|Drug|Antioxidants|
5820449|NCT00046358|Drug|Lovostatin|
5820450|NCT00046358|Drug|Ibuprofen|
5820451|NCT00046293|Drug|Reopro|
5820452|NCT00046293|Drug|Retrovase|
5820453|NCT00046267|Drug|Niacin|
5820454|NCT00046254|Drug|Zoledronic Acid|
5820455|NCT00046241|Drug|Extended-release bupropion hydrochloride|
5820456|NCT00046228|Drug|abciximab placebo; reteplase placebo, abciximab, abciximab|placebo bolus; 1-2 placebo bolus; 0.25 mg/kg bolus; 0.125 ¼g/kg/min, max 10 ¼g/min infusion x 12h
5820457|NCT00046228|Drug|Abciximab; reteplase; abciximab placebo; abciximab|0.25 mg/kg bolus; 1-2, 5 unit boluses; placebo bolus; 0.125 ¼g/kg/min, max 10 ¼g/min infusion x 12h
5820458|NCT00046228|Drug|abciximab; reteplase placebo; abciximab placebo; abciximab|0.25 mg/kg bolus; 1-2 placebo boluses; placebo bolus; 0.125 ¼g/kg/min, max 10 ¼g/min infusion x 12h
5820459|NCT00046228|Drug|abciximab placebo; reteplase placebo, abciximab, abciximab|placebo bolus; 1-2 placebo bolus; 0.25 mg/kg bolus; 0.125 ¿g/kg/min, max 10 ¿g/min infusion x 12h
5820460|NCT00046228|Drug|abciximab; reteplase placebo; abciximab placebo; abciximab|0.25 mg/kg bolus; 1-2 placebo boluses; placebo bolus; 0.125 ¿g/kg/min, max 10 ¿g/min infusion x 12h
5820461|NCT00046228|Drug|Abciximab; reteplase; abciximab placebo; abciximab|0.25 mg/kg bolus; 1-2, 5 unit boluses; placebo bolus; 0.125 ¿g/kg/min, max 10 ¿g/min infusion x 12h
5820462|NCT00046176|Drug|abacavir/lamivudine|
5820463|NCT00046176|Drug|abacavir|
5820464|NCT00046176|Drug|lamivudine|
5820465|NCT00046163|Drug|midodrine hydrochloride (ProAmatine®)|
5820466|NCT00046150|Drug|Insulin glulisine (HMR1964)|
5820467|NCT00046137|Drug|teriparatide|
5820468|NCT00046137|Drug|raloxifene|
5820469|NCT00046137|Drug|placebo|
5820470|NCT00046111|Drug|topotecan|A topoisomerase I inhibitor used for ovarian and lung cancer treatment
5820471|NCT00046085|Behavioral|Online Family Education|Families were provided with private, secure access to the website, which features family-to-family chat capabilities, video lectures on the management of schizophrenia, written materials on important issues in schizophrenia management, professionally facilitated online discussions of the material, and additional resource links.
5820472|NCT00046085|Behavioral|Customary care|Participants received care as usual.
5820473|NCT00046072|Drug|E5564|
5820474|NCT00046033|Drug|Lopinavir/ritonavir|
5820475|NCT00046033|Drug|Ritonavir|
5820476|NCT00046033|Drug|Saquinavir|
5820477|NCT00046033|Drug|Tenofovir disoproxil fumarate|
5820478|NCT00046033|Drug|Amprenavir|
5820479|NCT00046020|Drug|Venlafaxine ER|
5820480|NCT00045994|Drug|ALT-711|
5820481|NCT00045981|Drug|ALT-711|
5820482|NCT00045968|Drug|Dendritic cell immunotherapy|Two intradermal (i.d.) injections of DCVax-L(treatment cohort) or autologous PBMC (placebo cohort) per treatment. Treatments will be given at days 0, 10, 20, and at weeks 8, 16, 32, 48, 72, 96 and 120.
5820483|NCT00045955|Drug|Fexofenadine, Comparator = Montelukast|
5820484|NCT00045942|Drug|Itraconazole|Itraconazole was commercially available.
5820485|NCT00045942|Drug|PKC412|PKC412 was supplied as soft gelatin capsules containing 25 mg PKC412.
5820486|NCT00045916|Procedure|High dosage electroconvulsive therapy|Participants will receive high dosage right unilateral ECT at six times the seizure threshold.
5820487|NCT00045916|Drug|Nortriptyline|Participants will receive nortriptyline.
5820488|NCT00045916|Drug|Venlafaxine|Participants will receive venlafaxine.
5820489|NCT00045916|Drug|Lithium|Participants will receive lithium.
5820490|NCT00045916|Procedure|Low dosage electroconvulsive therapy|Participants will receive low dosage bilateral ECT at one and a half times the seizure threshold.
5820491|NCT00045903|Behavioral|Exposure and Ritual Prevention (Cognitive Behavioral Therapy)|
5820492|NCT00045903|Behavioral|Stress Management Therapy (Cognitive Behavior Therapy)|
5820493|NCT00044824|Drug|Fexofenadine|
5820494|NCT00044811|Drug|Fexofenadine|
5820495|NCT00045877|Drug|Recombinant Human Interleukin-2 and Rituximab|
5820496|NCT00045864|Drug|Recombinant Human Interleukin-2 and Rituximab|
5820497|NCT00045838|Drug|VCR-HIVDNA006-00-VP|
5820498|NCT00045812|Drug|SCH-58235|
5820499|NCT00045799|Drug|Omeprazole sodium bicarbonate immediate release PWD/FS|
5820500|NCT00045799|Drug|Cimetidine IV|
5820501|NCT00045786|Drug|CC-1088|400 mg/day (200 mg orally twice a day) 800 mg/day (400 mg orally twice a day) 1200 mg/day (600 mg orally twice a day) 1500 mg/day (500 mg orally three times daily)
5820502|NCT00045773|Drug|Sertraline|50 - 200mg, once per day for 12 weeks.
5820503|NCT00045760|Drug|Drotrecogin alfa (activated)|
5820504|NCT00044928|Drug|Piperacillin/Tazobactam|
5820505|NCT00044915|Drug|Repinotan HCl (BAYX3702)|All patients receive 1.25 mg of repinotan
5820506|NCT00044915|Drug|Placebo|All patients receive 1.25 mg of placebo
5820507|NCT00044902|Drug|epratuzumab|
5820508|NCT00044889|Drug|clofarabine (IV formulation)|
5820509|NCT00044863|Biological|Erbitux (Cetuximab)|400 mg/m2 initial dose, 250 mg/m2 weekly
5820510|NCT00044837|Drug|Medroxyprogesterone acetate|
5820511|NCT00044837|Drug|Estradiol|
5820512|NCT00044876|Drug|CDB-2914|
5820513|NCT00044798|Procedure|Repetitive transcranial magnetic stimulation (rTMS)|Participants will receive 15 treatments of rTMS over 3 weeks.
5820514|NCT00044798|Drug|Citalopram|After completing treatment with rTMS or sham rTMS, participants will take citalopram for 9 weeks.
5820515|NCT00044798|Procedure|Sham rTMS|Participants will receive 15 treatments of sham rTMS over 3 weeks.
5820516|NCT00044785|Drug|triacetyluridine|
5820517|NCT00044785|Drug|fluorouracil|
5820518|NCT00044785|Drug|leucovorin|
5820519|NCT00044785|Drug|camptosar|
5820520|NCT00044772|Drug|Venlafaxine ER|
5820521|NCT00044759|Drug|Piperacillin/Tazobactam (Tazocin)|
5820522|NCT00044746|Drug|Piperacillin/Tazobactam|
5820523|NCT00044733|Drug|Mylotarg (gemtuzumab ozogamicin) Injection|
5820524|NCT00044720|Drug|Rapamune|
5820525|NCT00044707|Drug|Pramlintide acetate|Clear, colorless, sterile solution for SC injection.
5820526|NCT00044694|Drug|Placebo 0.01 mL|2-week placebo lead-in period (0.01 mL) followed by 4 weeks of Placebo 0.01 mL subcutaneously injected twice daily
5820527|NCT00044694|Drug|Placebo 0.02 mL|2-week placebo lead-in period (0.01 mL) followed by 4 weeks of Placebo 0.02 mL subcutaneously injected twice daily
5820528|NCT00044694|Drug|Placebo 0.03 mL|2-week placebo lead-in period (0.01 mL) followed by 4 weeks of Placebo 0.03 mL subcutaneously injected twice daily
5820529|NCT00044694|Drug|Placebo 0.04 mL|2-week placebo lead-in period (0.01 mL) followed by 4 weeks of Placebo 0.04 mL subcutaneously injected twice daily
5820530|NCT00044694|Drug|AC2993 2.5 mcg|2-week placebo lead-in period (0.01 mL) followed by 4 weeks of AC2993 2.5 mcg (0.01 mL) subcutaneously injected twice daily
5820531|NCT00044694|Drug|AC2993 5.0 mcg|2-week placebo lead-in period (0.01 mL) followed by 4 weeks of AC2993 5.0 mcg (0.02 mL) subcutaneously injected twice daily
5820532|NCT00044694|Drug|AC2993 7.5 mcg|2-week placebo lead-in period (0.01 mL) followed by 4 weeks of AC2993 7.5 mcg (0.03 mL) subcutaneously injected twice daily
5820533|NCT00044694|Drug|AC2993 10.0 mcg|2-week placebo lead-in period (0.01 mL) followed by 4 weeks of AC2993 10.0 mcg (0.04 mL) subcutaneously injected twice daily
5820534|NCT00044681|Drug|risperidone|
5820535|NCT00044668|Drug|AC2993|Subjects will receive 5 μg AC2993, subcutaneously injected twice daily, for 4 weeks followed by 10 μg AC2993, subcutaneously injected twice daily, during a maintenance period that is expected to continue for at least 11 months.
5820536|NCT00044655|Drug|Risperidone|As prescribed by routine prescriber (not dictated by study protocol)
5820537|NCT00044655|Drug|Olanzapine|As prescribed by routine prescriber (not dictated by study protocol)
5820538|NCT00044655|Drug|Ziprasidone|As prescribed by routine prescriber (not dictated by study protocol)
5820539|NCT00044655|Drug|Quetiapine|As prescribed by routine prescriber (not dictated by study protocol)
5820540|NCT00044655|Drug|Aripiprazole|As prescribed by routine prescriber (not dictated by study protocol)
5820541|NCT00044642|Drug|Lorazepam|
5820542|NCT00044629|Behavioral|Cognitive-Behavioral Therapy for Insomnia|
5820543|NCT00044629|Drug|zolpidem tartrate (Ambien)|
5820544|NCT00044629|Drug|Placebo|
5820545|NCT00044616|Drug|Fluoxetine|
5820546|NCT00044616|Drug|Lithium|
5820547|NCT00044577|Drug|abacavir/lamivudine|
5820548|NCT00044577|Drug|abacavir|
5820549|NCT00044577|Drug|lamivudine|
5820550|NCT00044577|Drug|tenofovir|
5820551|NCT00044564|Drug|Bay 59-8862|75 mg/m2 of BAY 59-8862 intravenously over one hour. Treatment will be repeated once every 3 weeks and tumor measurements will be made every 2 cycles till progression, unacceptable toxicity or consent withdrawal
5820552|NCT00044551|Drug|Taxane (Cytotoxic, BAY59-8862)|Daily 1 h infusion every 3 weeks
5820553|NCT00044538|Drug|BAY59-8862 (Cytotoxic Taxane)|Intravenous dose over 60 minutes every 3 weeks
5820554|NCT00044525|Drug|BAY59-8862 (Cytotoxic Taxane)|1 h intravenous infusion every 3 weeks
5820555|NCT00044512|Drug|Sorafenib (Nexavar, BAY43-9006)|Sorafenib (Nexavar, BAY43-9006) 400 mg administered bis in die (bid, twice a day)
5820556|NCT00044486|Drug|Posaconazole oral suspension|
5820557|NCT00044473|Drug|levofloxacin|
5820558|NCT00044460|Drug|rosiglitazone|
5820559|NCT00044447|Drug|Glimepiride|
5820560|NCT00044434|Drug|bupropion (Wellbutrin)|
5820561|NCT00044421|Drug|Ruboxistaurin mesylate|
5820562|NCT00044408|Drug|Ruboxistaurin mesylate|
5820563|NCT00044395|Drug|Ruboxistaurin mesylate|
5820564|NCT00044382|Drug|CC-5013|
5820565|NCT00044369|Procedure|Varicocele repair|
5820566|NCT00044356|Genetic|Allovectin-7®|
5820567|NCT00044343|Drug|lapatinib|
5820568|NCT00044291|Drug|atamestane|
5820569|NCT00044291|Drug|toremifene|
5820570|NCT00044291|Drug|letrozole|
5820571|NCT00044291|Drug|aromatase inhibition|
5820572|NCT00044291|Procedure|hormone therapy|
5820573|NCT00044291|Procedure|endocrine therapy|
5820574|NCT00044291|Procedure|antiestrogen therapy|
5820575|NCT00044304|Drug|Imatinib|The dosing regimen to be used initially (400 mg po qd in adults and 260 mg/m2/day in children with food and a glass of water) is identical to that recommended by the FDA for the treatment of the chronic phase of chronic myelogenous leukemia (CML) (Prod Info Gleevec ). In patients with ANC<1500/mm3, platelet counts < 75,000mm3 or abnormal liver function tests (ALT or AST > 2.5 or bilirubin > 3 times the upper limit of normal), the starting dose will be reduced to 300 mg poqD.
5820576|NCT00044304|Drug|Ruxolitinib|The dosing regimen to be used initially (15 mg po bid) is identical to that recommended by the FDA for the treatment of myelofibrosis with platelet counts of 100-200,000/mm3 (Prod Info ruxolitinib). In patients with platelet counts <100,000/mm3, moderate renal impairment (CrCl <60 ml/min) or abnormal liver function tests (AlT or AST > 2.5 or bilirubin > 3 times the upper limit of normal), the starting dose will be reduced to 10 mg bid. The recommended guidelines for dose adjustment during therapy and discontinuation of therapy in myelofibrosis will be followed.
5820577|NCT00044278|Drug|lamotrigine|
5820578|NCT00044265|Drug|ramipril|
5820579|NCT00044226|Drug|ML-04A|
5820580|NCT00044213|Drug|EDTA|Participants will receive 40 infusions of standard chelation solution.
5820581|NCT00044213|Drug|EDTA Placebo|Participants will receive 40 infusions of EDTA placebo.
5820582|NCT00044213|Dietary Supplement|High Dose Vitamin|
5820583|NCT00044213|Dietary Supplement|High Dose Vitamin Placebo|
5820584|NCT00044187|Drug|Sibutramine|
5820585|NCT00044148|Drug|LY333531|
5820586|NCT00044135|Drug|clevudine (drug)|
5820587|NCT00044070|Drug|YM872 (zonampanel)|
5820588|NCT00044057|Drug|YM872 (zonampanel), t-PA (alteplase)|
5820589|NCT00044044|Drug|Lurasidone 20 mg|Lurasidone 20mg/day tablets
5820590|NCT00044044|Drug|Lurasidone 40mg|Lurasidone 40mg/day tablets
5820591|NCT00044044|Drug|Lurasidone 80 mg|Lurasidone 80mg/day - 2 40mg tablets
5820592|NCT00044044|Drug|Haloperidol 10mg|Haloperidol 10mg/day tablets
5820593|NCT00044044|Drug|Placebo|Matching Placebo to Lurasdione and Haloperidol
5820594|NCT00044031|Biological|G17DT Immunogen|
5820595|NCT00044018|Drug|CDC-501|
5820596|NCT00044005|Drug|Lurasidone 20 mg|Lurasidone 20mg oral tablet taken once daily for 6-months
5820597|NCT00044005|Drug|Lurasidone 40 mg|Lurasidone 40mg oral tablets taken once daily
5820598|NCT00044005|Drug|Lurasidone 80mg|Lurasidone 80mg oral tablet taken once daily
5820599|NCT00043329|Drug|Actimmune Registry|as administered by physician
5820600|NCT00044109|Device|Magnets|
5820601|NCT00044083|Other|Placebo|Placebo: One capsule 3 times a day from Day 1 to Day 7
5820602|NCT00044083|Drug|Tolcapone|Tolcapone: One capsule 3 times a day from Day 1 to Day 7
5820603|NCT00043966|Drug|Lopinavir/ritonavir|
5820604|NCT00043966|Drug|Tenofovir DF|
5820605|NCT00043966|Drug|Emtricitabine|
5820606|NCT00043953|Drug|Lopinavir/ritonavir|
5820607|NCT00043953|Drug|Saquinavir mesylate|
5820608|NCT00043953|Drug|Lamivudine/zidovudine|
5820609|NCT00043888|Drug|fosamprenavir|
5820610|NCT00043888|Drug|COMBIVIR|
5820611|NCT00043888|Drug|ritonavir|
5820612|NCT00043888|Drug|TRIZIVIR|
5820613|NCT00043979|Drug|F-18 Fluorodeoxyglucose|
5820614|NCT00043979|Biological|therapeutic allogeneic lymphocytes|Lymphocyte cells are collected from a healthy donor by apheresis and infused into the patient with a central venous catheter.
5820615|NCT00043979|Drug|cyclophosphamide|"Induction - 750 mg/m^2 intravenous (IV) infusion over 30 minutes x 1 dose. Day 5.~Transplant - 1200 mg/m^2 per day IV infusion over 2 hours daily for 4 days; days -6, -5, -4, -3."
5820616|NCT00043979|Drug|cyclosporine|6 mg/kg per dose orally every other day (no day 9 dose).
5820617|NCT00043979|Drug|doxorubicin hydrochloride|Induction - 10 mg/m^2 per day continuous intravenous (IV) infusion over 24 hours daily for 4 days. Days 1, 2, 3, 4.
5820618|NCT00043979|Drug|etoposide|50 mg/m^2 per day continuous intravenous (IV) infusion over 24 hours daily for 4 days. Days 1, 2, 3, 4.
5820619|NCT00043979|Drug|fludarabine phosphate|"Induction - 25 mg/m^2 per day intravenous (IV) infusion over 30 minutes daily for 3 days. Days 1, 2, 3.~Transplant - 30 mg/m^2 per day IV infusion over 30 minutes daily for 4 days; days -6, -5, -4, -3."
5820620|NCT00043979|Drug|melphalan|Transplant - 100 mg/m^2 per day intravenous (IV) infusion over 15 minutes for 1 day; day -2.
5820621|NCT00043979|Drug|prednisone|Induction - 60 mg/m^2 per day in 2-4 divided doses by mouth daily for 5 days; days 1, 2, 3, 4, 5.
5820622|NCT00043979|Drug|sirolimus|Initiated on day +3. Patients >40kg, the initial dose will be 2 mg every 24 hours orally. Patients <40 kg, the initial dose will be 1 mg/m^2.
5820623|NCT00043979|Drug|tacrolimus|Day -1 at least 24 hours before the stem cell infusion at a dose of 0.03 mg/kg/day as a continuous infusion. Twelve hours later oral dose initiated at a dose of 0.1-0.15 mg/kg/day in two divided doses every 12 hours.
5820624|NCT00043979|Drug|vincristine sulfate|Induction - 0.4 mg/m^2 per day continuous intravenous (IV) infusion over 24 hours daily for 4 days; 1, 2, 3, 4.
5820625|NCT00043979|Procedure|peripheral blood stem cell transplantation|Stem cells from a healthy donor are collected and transplanted into the patient using a central venous catheter.
5820626|NCT00043979|Drug|Filgrastim|
5820627|NCT00043979|Procedure|Peripheral Blood Stem Cell donation|
5820628|NCT00043940|Drug|bivalirudin|Bivalirudin therapy will be given as a 0.75-mg/kg intravenous bolus and 1.75-mg/kg/h intravenous infusion during procedure and up to 4 hours.
5820629|NCT00043927|Drug|topotecan/cisplatin|
5820630|NCT00043927|Drug|etoposide/cisplatin|
5820631|NCT00043914|Drug|lamotrigine|
5820632|NCT00043901|Drug|lamotrigine|
5820633|NCT00043875|Drug|lamotrigine|
5820634|NCT00043862|Drug|topotecan|
5820635|NCT00043849|Drug|Quetiapine|
5820636|NCT00043836|Drug|ALT-711|
5820637|NCT00043823|Drug|Avastin|7.5 mg/kg By Vein on Day 1 of Every 21 Day Cycle
5820638|NCT00043823|Drug|Tarceva|100 mg By Mouth Daily for 3 Weeks
5820639|NCT00043810|Procedure|Gelonin|Gelonin-AntiCD33 purging, 3 purging concentrations (fixed dose of 5 x 10^6 CD34+ cells/kg to be infused) with 3 dose levels of 1 nanomolar, 5.0 nanomolar and 10.0 nanomolar.
5820640|NCT00043810|Drug|Busulfan|130 mg/m2 in normal saline over three (3) hours IV every twenty-four (24) hours for four (4) consecutive days (days -6 to -3).
5820641|NCT00043810|Drug|Fludarabine|40 mg/m2 in 100 ml of saline over one (1) hour on each of four (4) consecutive days (days - 6 to -3).
5820642|NCT00043797|Drug|Lidorestat (IDD 676)|
5820643|NCT00043784|Drug|enoxaparin|
5820644|NCT00043693|Behavioral|Family Intervention for Dual Diagnosis|The family intervention for dual diagnosis program lasts for up to 3 years and includes both single and multiple-family group formats.
5820645|NCT00043693|Behavioral|Family psychoeducation program|The family psychoeducation program consists of 6 weekly sessions.
5820646|NCT00043771|Drug|Tolvaptan|
5820647|NCT00043758|Drug|Tolvaptan|
5820648|NCT00043745|Dietary Supplement|Soy isoflavones|Soy isoflavones extracted from soy protein, compressed into tablets; three tablets taken daily
5820649|NCT00043745|Dietary Supplement|Extract tablets|Extract from soy protein, but devoid of isoflavones; three tablets taken once daily
5820650|NCT00043732|Drug|SCIO-469|
5820651|NCT00043719|Drug|Nitroglycerin ointment|
5820652|NCT00043719|Drug|Calcium supplement with vitamin D|
5820653|NCT00043706|Drug|Human Anti-Transforming Growth Factor Beta-1 Monoclonal Antibody|
5820654|NCT00043602|Behavioral|Standard interpersonal psychotherapy (IPT)|Participants will receive 12 sessions of IPT over 12 weeks.
5820655|NCT00043602|Behavioral|Clinician managed interpersonal psychotherapy (CM-IPT)|Participants will receive 12 sessions of CM-IPT over 1 year.
5820656|NCT00043589|Drug|donepezil|
5820657|NCT00043589|Procedure|Memory-training class|
5820658|NCT00043576|Drug|calcitriol|
5820659|NCT00043576|Drug|docetaxel|
5820660|NCT00043680|Drug|Celecoxib|
5820661|NCT00043667|Drug|Daclizumab|
5820662|NCT00043654|Drug|Mifepristone|
5820663|NCT00043628|Procedure|Stem Cell Mobilization|
5820664|NCT00043563|Behavioral|Cognitive-Behavior Therapy|
5820665|NCT00043550|Behavioral|Supportive Expressive Therapy|The aim of supportive-expressive psychotherapy is to help patients understand the causes of relationship conflicts in the context of a supportive relationship.
5820666|NCT00043550|Drug|Sertraline|Participants will receive sertraline.
5820667|NCT00043550|Drug|Pill Placebo|Participants will receive a pill placebo.
5820668|NCT00043550|Drug|Venlafaxine|Participants will receive venlafaxine.
5820669|NCT00043537|Behavioral|Social Effectiveness Therapy for Children (SET-C)|
5820670|NCT00043537|Drug|Fluoxetine|
5820671|NCT00043537|Drug|Pill Placebo|
5820672|NCT00043511|Biological|pGA2/JS2 Plasmid DNA Vaccine|
5820673|NCT00043459|Drug|intravenous T900607-sodium|
5820674|NCT00043446|Drug|intravenous T900607-sodium|
5820675|NCT00043433|Drug|intravenous T900607-sodium|
5820676|NCT00043420|Drug|PF-3512676|Weekly subcutaneous injections of 0.08mg/kg PF-3512676. Treatment continues for a minimum of 8 weeks unless disease progression or unacceptable toxicity occurs, or a maximum of 24 weeks.
5820677|NCT00043420|Drug|PF-3512676|Weekly subcutaneous injections of 0.16mg/kg PF-3512676. Treatment continues for a minimum of 8 weeks unless disease progression or unacceptable toxicity occurs, or a maximum of 24 weeks.
5820678|NCT00043420|Drug|PF-3512676|Weekly subcutaneous injections of 0.24mg/kg PF-3512676. Treatment continues for a minimum of 8 weeks unless disease progression or unacceptable toxicity occurs, or a maximum of 24 weeks.
5820679|NCT00043420|Drug|PF-3512676|Weekly subcutaneous injections of 0.28mg/kg PF-3512676. Treatment continues for a minimum of 8 weeks unless disease progression or unacceptable toxicity occurs, or a maximum of 24 weeks.
5820680|NCT00043420|Drug|PF-3512676|Weekly subcutaneous injections of 0.32mg/kg PF-3512676. Treatment continues for a minimum of 8 weeks unless disease progression or unacceptable toxicity occurs, or a maximum of 24 weeks.
5820681|NCT00043420|Drug|PF-3512676|Weekly subcutaneous injections of 0.36mg/kg PF-3512676. Treatment continues for a minimum of 8 weeks unless disease progression or unacceptable toxicity occurs, or a maximum of 24 weeks.
5820682|NCT00043420|Drug|PF-3512676|Weekly subcutaneous injections of 10 mg PF-3512676. Treatment continues for a minimum of 8 weeks unless disease progression or unacceptable toxicity occurs, or a maximum of 24 weeks.
5820683|NCT00043420|Drug|PF-3512676|Weekly subcutaneous injections of 25 mg PF-3512676. Treatment continues for a minimum of 8 weeks unless disease progression or unacceptable toxicity occurs, or a maximum of 24 weeks.
5820684|NCT00043407|Drug|CPG 7909|In the phase I portion of the protocol, patients will be included in escalating dose groups: 0.08, 0.12, 0.16, 0.36, 0.54 or 0.81 mg/kg of CPG 7909 Injection. Patients will be treated once weekly subcutaneously for 24 weeks. In the Phase II portion of the trial patients will be treated at the MTD or the highest dose of 0.81 mg/kg identified in the Phase I dose escalation portion of the trial. All patients in Phase I and Phase II will be treated until disease progression or a maximum of 24 weeks.
5820685|NCT00043394|Drug|0.04 mg/kg CpG 7909|0.04 mg/kg CpG 7909 by subcutaneous Injection once weekly until progression or 24 weeks
5820686|NCT00043394|Drug|Herceptin®|Herceptin® (maintenance dose per the manufacturer's directions) followed by a subcutaneous injection of CpG 7909.
5820687|NCT00043394|Drug|0.08 mg/kg CpG 7909|0.08 mg/kg CpG 7909 by subcutaneous Injection once weekly until progression or 24 weeks
5820688|NCT00043394|Drug|Herceptin®|Herceptin® (maintenance dose per the manufacturer's directions) followed by a subcutaneous injection of CpG 7909.
5820689|NCT00043394|Drug|0.12 mg/kg CpG 7909|0.12 mg/kg CpG 7909 by subcutaneous Injection once weekly until progression or 24 weeks
5820690|NCT00043394|Drug|Herceptin®|Herceptin® (maintenance dose per the manufacturer's directions) followed by a subcutaneous injection of CpG 7909.
5820691|NCT00043394|Drug|0.16 mg/kg CpG 7909|0.16 mg/kg CpG 7909 by subcutaneous Injection once weekly until progression or 24 weeks
5820692|NCT00043394|Drug|Herceptin®|Herceptin® (maintenance dose per the manufacturer's directions) followed by a subcutaneous injection of CpG 7909.
5820693|NCT00043381|Drug|decitabine (5-aza-2'deoxycytidine)|
5820694|NCT00043368|Drug|PF-3512676|PF-3512676 IV at doses: 0.01mg/kg, 0.16mg/kg and 0.32mg/kg PF-3512676 Injection given by subcutaneous injection at doses: 0.04mg/kg, 0.16mg/kg, 0.20mg/kg, 0.28mg/kg, 0.32mg/kg, 6mg, 10mg, 40mg.
5820695|NCT00043355|Drug|interferon gamma-1b|500 mcg, oral, three times weekly
5820696|NCT00043342|Drug|interferon gamma-1b|100 or 200 mcg, SQ, 3x per week
5820697|NCT00043316|Drug|interferon gamma-1b|500 or 1000 mcg, inhalation, 3x per week
5820698|NCT00043303|Drug|interferon gamma-1b|100 or 200 mcg, SQ, 3x per week
5820699|NCT00043277|Drug|Angiomax (bivalirudin)|
5820700|NCT00043264|Drug|Rifampin|
5820701|NCT00043264|Drug|Azithromycin|
5820702|NCT00043212|Drug|Dendritic cell immunotherapy|
5820703|NCT00043199|Drug|Aroplatin (Liposomal NDDP, L-NDDP)|
5820704|NCT00043186|Drug|Placebo|Placebo subcutaneous injection
5820705|NCT00043186|Drug|Denosumab|Denosumab for subcutaneous injection
5820706|NCT00043186|Drug|Alendronate|Alendronate 70 mg tablets
5820707|NCT00042718|Drug|levofloxacin, azithromycin, amoxicillin/clavulanate|
5820708|NCT00042679|Drug|Gemcitabine|
5820709|NCT00042679|Drug|Carboplatin|
5820710|NCT00042679|Drug|LY900003|
5820711|NCT00042666|Drug|LY317615|500 mg, oral, daily, up to six 28 day cycles
5820712|NCT00042653|Drug|Placebo|30 mg of placebo taken once daily orally 60 mg of placebo taken once daily orally 90 mg of placebo taken once daily orally 120 mg of placebo taken once daily orally 180 mg of placebo taken once daily orally
5820713|NCT00042653|Drug|AMG 073|30 mg of AMG 073 taken once daily orally 60 mg of AMG 073 taken once daily orally 90 mg of AMG 073 taken once daily orally 120 mg of AMG 073 taken once daily orally 180 mg of AMG 073 taken once daily orally
5820714|NCT00042601|Drug|Pramlintide acetate|Pramlintide injection will be supplied in 5-mL multidose glass vials with rubber stoppers.
5820715|NCT00042601|Drug|Placebo|placebo injection will be supplied in 5-mL multidose glass vials with a rubber stopper
5820716|NCT00042588|Drug|Recombinant Chimeric Monoclonal Antibody|
5820717|NCT00042575|Drug|Duloxetine|
5820718|NCT00042562|Drug|duloxetine|
5820719|NCT00042549|Device|Extracorporeal Shock Wave Lithotripsy|
5820720|NCT00042549|Drug|ursodiol|
5820721|NCT00042536|Drug|Naltrexone HCL/ Yohimbine HCL|
5820722|NCT00042510|Biological|Treatment group|
5820723|NCT00042497|Biological|autologous dexosomes loaded with tumor-specific peptides|
5820724|NCT00042484|Procedure|Community-level intervention & policy change|
5820725|NCT00042471|Drug|Pramlintide acetate|Pramlintide acetate (AC137) injection is a clear, colorless, sterile solution for injection. It consists of pramlintide in sodium acetate buffer, pH 4.0, containing 43mg/mL mannitol as an iso-osmolality modifier and 2.25 mg/mL metacresol as a preservative. The strength of pramlintide is 1.0 mg/mL for SC injection and 0.6 mg/mL for IV bolus injection.
5820726|NCT00042458|Drug|Pramlintide acetate|Pramlintide injection will be supplied in 5-mL multidose glass vials with rubber stoppers.
5820727|NCT00042458|Drug|Placebo|The placebo injection will be supplied in the same 5-mL multidose glass vials with a rubber stopper.
5820728|NCT00042432|Drug|cinacalcet (AMG 073)|Initially receive 1 tablet of study medication (cinacalcet or placebo) once daily. Possible sequential dose titrations are 30, 60, 90, 120, 180mg cinacalcet or placebo) daily. The titration phase was 12 weeks and the efficacy assessment phase was 6 weeks.
5820729|NCT00042406|Drug|HuMax-CD4|
5820730|NCT00042393|Drug|Adefovir Dipivoxil|
5820731|NCT00042367|Drug|Induction therapy (Regimen 1, Course 1, Cycle A1|"2-8 hrs: Cisplatin 3.5 mg/kg + mannitol 0.4 g/kg in D5 NS (1000 ml/m2) over 6 hrs at approximately 167ml/m2/hr. 8-12 hrs: D5 NS (665 ml/m2) + KCl (2 mEq/100 ml) +MgSO4 (0.5 mEq/100 ml) at approximately 167ml/m2/hr.~12-24 hrs: D5 NS + KCl (2 mEq/100 ml) + MgSO4 (0.5mEq/100 ml) at approximately 65 ml/m2/hr.~Days 2,3: 0 hrs: Mesna 6 mg/kg IV in 0.65 ml/kg of IVF over 15 min 15 min: Cyclophosphamide 30 mg/kg IV over 30 min 45 min: Post-chemotherapy hydration - D5 1/2 NS + KCl(1 mEq/100 ml) at approximately 130 ml/m2/hr for at least 24 hours.~3 hrs: Mesna 6 mg/kg IV in 0.65 ml/kg IVF over 15 min 6 hrs: Mesna 6 mg/kg IV in 0.65 ml/kg IVF over 15 min 9 hrs: Mesna 6 mg/kg IV in 0.65 ml/kg IVF over 15 min 12 hrs: Mesna 6 mg/kg IV in 0.65 ml/kg IVF over 15 min Day 4 G-CSF 5 µg/kg subcutaneously, daily until ANC ≥ 2000 on two consecutive days, post ANC nadir.~Day 8: Vincristine 0.05 mg/kg IV push (max dose = 2 mg) Day 15: Vincristine 0.05 mg/kg IV push (max dose = 2 mg)"
5820732|NCT00042367|Drug|Regimen 1, Course 1, Cycle A2 (Days 22 - 42)|Drugs and doses are same as in Cycle A1. Cycle A2 begins following recovery from Cycle A1, but no sooner than day 21. Patients with delays in recovery beyond day 28 should have dose modifications
5820733|NCT00042367|Drug|Cycle B|"Days 43 - 63) Etoposide, 1.7 mg/kg p.o. qd x 21 days. The dose will be diluted immediately prior to administration in juice flavored syrup to a final concentration of 0.4 Each dose should be aken 1 hour before or 2 hours after a meal.~Cycle B begins following recovery from Cycle A2; however, it begin no sooner than 21 days after the start of Cycle A2.~Monitor weekly CBC/diff/plt. If ANC < 500/mm3 or platelets (unsupported) < 50,000/mm3 then discontinue etoposide. A 25% reduction should be made for the next cycle of oral etoposide.~Interim Response Evaluation (Days 64 - 70) Interim Response Evaluation should be performed the week following the completion of Course 1."
5820734|NCT00042367|Drug|Regimen 1, Course 2|6.3.3 Regimen 1, Course 2 Repeat systemic therapy as per Course 1 (Cycle A1, Cycle A2, and Cycle B) in patients with SD or better at the interim response evaluation (see Figure 2 for IT mafosfamide guidelines). Course 2 should not begin any sooner than 7 days after the completion of Course 1.
5820735|NCT00042367|Drug|Intrathecal Mafosfamide|Regimen 1, Course 1 Mafosfamide, 14 mg, is given two times/week during Cycle A1 and Cycle A2 of Course 1, for 12 total doses during days 1-41. The first dose of Cycles A1 and A2 should be given, if possible, on the same day as the first I.V. cyclophosphamide dose and the second dose 3 to 4 days later. The assigned dose is given one time/week during Cycle B, Course 1 for 3 total doses during days 43 - 63.
5820736|NCT00042367|Drug|Regimen 1 Course 2, IT mafosfamide|"Regimen 1, Course 2 The assigned dose is administered once with IV cyclophosphamide during each of Cycle A1 and Cycle A2, and day 1 of Cycle B for a total of 3 doses during Course 2.~Patients with an initially abnormal flow study, who show no evidence of obstructive hydrocephalus or compartmentalization on the repeat study, may begin intrathecal mafosfamide administration with the initiation of Regimen 1, Course 2. The frequency of intrathecal mafosfamide administration, for such patients, will be as outlined in Regimen 1, Course~1."
5820737|NCT00042367|Drug|Regimen 2, Course 1|"Cycle C1 (Days 1 - 21) Day 1: Prehydrate with D5W 1/2 NS + KCl 2 mEq/100 ml) at 2 times the hourly maintenance rate until the urine specific gravity is < 1.012.~0 hrs: Mesna 6 mg/kg IV over 15 min. Dilute in 0.65 ml/kg IVF. 15 min: Vincristine 0.05 mg/kg IV push (Day 1 only)(max dose = 2 mg) 20 min: Cyclophosphamide 30 mg/kg IV over 30 min. 50 min: Post-chemotherapy hydration - D5 1/2 NS + KCl~(1 mEq/100 ml) at twice the hourly maintenance rate for at least 24 hours. 3 hrs: Mesna 6 mg/kg IV in 0.65 ml/kg IVF over 15 min 6 hrs: Mesna 6 mg/kg IV in 0.65 ml/kg IVF over 15 min 9 hrs: Mesna 6 mg/kg IV in 0.65 ml/kg IVF over 15 min 12 hrs: Mesna 6 mg/kg IV in 0.65 ml/kg IVF over 15 min Day 2: Repeat day 1, but omit vincristine. Day 3: G-CSF 5 µg/kg/day subcutaneously, daily, until ANC is > 2000 on two consecutive days, post ANC nadir."
5820738|NCT00042367|Drug|Regimen 2, Course, 1, Cycle C1|"Cycle C1, Weeks 2 and 3 Day 8: Vincristine 0.05 mg/kg IV push (max dose = 2 mg) Day 15: Vincristine 0.05 mg/kg IV push (max dose = 2 mg) Cycle C2 (Days 22-42) Drugs and doses are same as in Cycle C1. Cycle C2 begins following recovery from Cycle C1, but no sooner than day 21. Patients with delays in recovery beyond day 28 should have dose modificationsCycle D (Days 43 - 63) Etoposide 1.7 mg/kg, po qd x 21 days The dose will be diluted immediately prior to administration in juice or flavored syrup as per section 3.4.3. Each dose should be taken 1 hour before or 2 hours after a meal.~Cycle D should begin following recovery from Cycle C2; however, it should begin no sooner than 21 days after the start of Cycle C2."
5820739|NCT00042367|Drug|Regimen 2, Course 2|Repeat Course 1 (Cycle C1, Cycle C2, and Cycle D) in patients with SD or better at the interim response evaluation. Chemotherapy should begin as soon as the patient has recovered from the toxicities of oral etoposide in cycle D, course 1. However, it should not begin any sooner than 7 days after the completion of Course 1.
5820789|NCT00042237|Behavioral|Schema Therapy|
5820790|NCT00042224|Procedure|Electroconvulsive Therapy (ECT)|ECT will be used to augment clozapine in schizophrenic patients who continue to have psychotic symptoms despite optimal treatment with clozapine.
5820791|NCT00042224|Drug|Clozapine|Patients with psychotic symptoms will receive clozapine
5820792|NCT00042211|Behavioral|Problem Solving Treatment|Brief Cognitive Behavioral Therapy
5820793|NCT00042211|Behavioral|Control|No treatment control
5820740|NCT00042367|Radiation|radiation therapy|"Conformal Irradiation Patients who are initially M0 with a CR, PR, or SD to Regimen 1 induction chemotherapy (with or without second surgery) will receive local irradiation using conformal techniques. Treatment will commence within 2 weeks of completing Regimen 1 or second surgery. Treatment planning and technique may involve 3D conformal,IMRT, or proton planning and delivery, provided the guidelines regarding volume, dose,and normal tissue restrictions are honored.~8.3.1 Fraction Size 180 cGy fractions will be used for all target volumes. 8.3.2 Fractionation Conventional fractionation will be used. Treatments will be given once daily, 5 days/week except for necessary interruptions secondary to medical or administrative reasons."
5820741|NCT00042354|Drug|clofarabine (IV formulation)|
5820742|NCT00042341|Drug|clofarabine (IV formulation)|
5820743|NCT00042328|Drug|Valacyclovir|
5820744|NCT00042315|Procedure|Chemotherapy|
5820745|NCT00042315|Drug|tariquidar + vinorelbine|
5820746|NCT00042315|Drug|placebo + vinorelbine|
5820747|NCT00042302|Procedure|Chemotherapy|
5820748|NCT00042302|Drug|tariquidar + paclitaxel/carboplatin|
5820749|NCT00042302|Drug|placebo + paclitaxel/carboplatin|
5820750|NCT00042289|Drug|atazanavir/cobicistat|Women will receive atazanavir/cobicistat as prescribed by their clinicians. (Dosage will vary for each participant.)
5820751|NCT00042289|Drug|darunavir/ritonavir|Women will receive darunavir/ritonavir as prescribed by their clinicians. (Dosage will vary for each participant.)
5820752|NCT00042289|Drug|darunavir/cobicistat|Women will receive darunavir/cobicistat as prescribed by their clinicians. (Dosage will vary for each participant.)
5820753|NCT00042289|Drug|etravirine|Women will receive etravirine as prescribed by their clinicians. (Dosage will vary for each participant.)
5820754|NCT00042289|Drug|elvitegravir/cobicistat|Women will receive elvitegravir/cobicistat as prescribed by their clinicians. (Dosage will vary for each participant.)
5820755|NCT00042289|Drug|dolutegravir|Women will receive dolutegravir as prescribed by their clinicians. (Dosage will vary for each participant.)
5820756|NCT00042289|Drug|tenofovir alafenamide fumarate (TAF)|Women will receive TAF as prescribed by their clinicians. (Dosage will vary for each participant.)
5820757|NCT00042289|Drug|TAF/cobicistat|Women will receive TAF/cobicistat as prescribed by their clinicians. (Dosage will vary for each participant.)
5820758|NCT00042289|Drug|TAF/ritonavir|Women will receive TAF/ritonavir as prescribed by their clinicians. (Dosage will vary for each participant.)
5820759|NCT00042289|Drug|efavirenz|Women will receive efavirenz as prescribed by their clinicians. (Dosage will vary for each participant.)
5820760|NCT00042289|Drug|lopinavir/ritonavir|Women will receive lopinavir/ritonavir as prescribed by their clinicians. (Dosage will vary for each participant.)
5820761|NCT00042289|Drug|nevirapine|Women will receive nevirapine as prescribed by their clinicians. (Dosage will vary for each participant.)
5820762|NCT00042289|Drug|rifampicin|Women will receive rifampicin as prescribed by their clinicians. (Dosage will vary for each participant.)
5820763|NCT00042289|Drug|ethambutol|Women will receive ethambutol as prescribed by their clinicians. (Dosage will vary for each participant.)
5820764|NCT00042289|Drug|isoniazid|Women will receive isoniazid as prescribed by their clinicians. (Dosage will vary for each participant.)
5820765|NCT00042289|Drug|pyrazinamide|Women will receive pyrazinamide as prescribed by their clinicians. (Dosage will vary for each participant.)
5820766|NCT00042289|Drug|rifampicin|Women will receive rifampicin as prescribed by their clinicians. (Dosage will vary for each participant.)
5820767|NCT00042289|Drug|kanamycin|Women will receive kanamycin as prescribed by their clinicians. (Dosage will vary for each participant.)
5820768|NCT00042289|Drug|amikacin|Women will receive amikacin as prescribed by their clinicians. (Dosage will vary for each participant.)
5820769|NCT00042289|Drug|capreomycin|Women will receive capreomycin as prescribed by their clinicians. (Dosage will vary for each participant.)
5820770|NCT00042289|Drug|moxifloxacin|Women will receive moxifloxacin as prescribed by their clinicians. (Dosage will vary for each participant.)
5820771|NCT00042289|Drug|levofloxacin|Women will receive levofloxacin as prescribed by their clinicians. (Dosage will vary for each participant.)
5820772|NCT00042289|Drug|ofloxacin|Women will receive ofloxacin as prescribed by their clinicians. (Dosage will vary for each participant.)
5820773|NCT00042289|Drug|ethionamide/prothionamide|Women will receive ethionamide/prothionamide as prescribed by their clinicians. (Dosage will vary for each participant.)
5820774|NCT00042289|Drug|terizidone/cycloserine|Women will receive terizidone/cycloserine as prescribed by their clinicians. (Dosage will vary for each participant.)
5820775|NCT00042289|Drug|para-aminosalicylic acid (PAS)|Women will receive PAS as prescribed by their clinicians. (Dosage will vary for each participant.)
5820776|NCT00042289|Drug|high dose isoniazid (INH)|Women will receive high dose INH as prescribed by their clinicians. (Dosage will vary for each participant.)
5820777|NCT00042289|Drug|bedaquiline|Women will receive bedaquiline as prescribed by their clinicians. (Dosage will vary for each participant.)
5820778|NCT00042289|Drug|clofazamine|Women will receive clofazamine as prescribed by their clinicians. (Dosage will vary for each participant.)
5820779|NCT00042289|Drug|delamanid|Women will receive delamanid as prescribed by their clinicians. (Dosage will vary for each participant.)
5820780|NCT00042289|Drug|linezolid|Women will receive linezolid as prescribed by their clinicians. (Dosage will vary for each participant.)
5820781|NCT00042289|Drug|pretomanid|Women will receive pretomanid as prescribed by their clinicians. (Dosage will vary for each participant.)
5820782|NCT00042289|Drug|atazanavir/ritonavir/tenofovir|Women will receive atazanavir/ritonavir/tenofovir as prescribed by their clinicians. (Dosage will vary for each participant.)
5820783|NCT00042289|Drug|ethinyl estradiol oral contraceptive|Women will receive ethinyl estradiol oral contraceptive as prescribed by their clinicians. (Dosage will vary for each participant.)
5820784|NCT00042289|Drug|etonogestrel implant|Women will receive etonogestrel implant as prescribed by their clinicians. (Dosage will vary for each participant.)
5820785|NCT00041483|Drug|Anecortave Acetate 15 mg sterile suspension|
5820786|NCT00041483|Other|Photodynamic Therapy (PDT)|
5820787|NCT00042380|Drug|Novasoy|
5820788|NCT00042250|Drug|Chemotherapy for hematologic malignancy|
5820794|NCT00042198|Behavioral|Cognitive behavior therapy|Up to 12 weekly, individual, hour-long sessions
5820795|NCT00042198|Behavioral|Supportive Stress Management|Up to 12 weekly, individual, hour-long sessions, focusing on application of relaxation and other stress management techniques to depressogenic stressors
5820796|NCT00042185|Behavioral|Dissonance Eating Disorder Prevention Program|In this intervention, participants voluntarily engaged in verbal, written, and behavioral exercises in which they critiqued the thin-ideal ideal. These exercises were conducted in sessions and in homework activities. For example, they wrote a counter-attitudinal essay about the costs associated with pursuit of the thin-ideal and engaged in a counter-attitudinal role-play in which they attempted to dissuade facilitators from pursuing the thin-ideal.
5820797|NCT00042185|Behavioral|Healthy Weight Intervention|In this intervention, participants were encouraged to make gradual healthy and lasting changes to their diet and physical activity to balance their energy needs with their energy intake, and thereby achieve a healthier weight and body satisfaction. With support from the facilitator and group members, they initiated an individual lifestyle change plan to reduce intake of fat and sugar and to increase exercise using behavioral modification principles. Food and exercise diaries were used to identify behaviors to target in this lifestyle modification and to monitor change. Motivational enhancement activities were used to promote motivation for behavior change.
5820798|NCT00042185|Behavioral|Expressive Writing Control Condition|In this condition, which is based on the work of Pennebaker (1997), participants wrote about emotionally significant topics in three individual weekly 45-minute sessions. They were told that research indicates that body dissatisfaction is linked to emotional issues and that expressive writing helps resolve these issues. Sample topics included relationships or goals. They were told that their work would not be read and were asked to write continuously for the duration of the session about an emotionally important topic.
5820799|NCT00042172|Drug|Donepezil|
5820800|NCT00042172|Drug|Ginkgo Biloba Extract|
5820801|NCT00042159|Device|repetitive transcranial magnetic stimulation|1 Hertz stimulation for 16 minutes per day at 90% motor threshold, 5 sessions each to the two primary cortical targets
5820802|NCT00042146|Behavioral|Cognitive-behavior therapy|
5820803|NCT00042146|Drug|zolpidem|
5820804|NCT00042094|Biological|Cell-Cultured Smallpox Vaccine compared to Dryvax®|
5820805|NCT00042081|Drug|CGT003 (E2F Duplex Decoy)|
5820806|NCT00042068|Drug|Meloxicam|
5820807|NCT00042055|Drug|CP-461|
5820808|NCT00042042|Behavioral|Family based educational program|
5820809|NCT00042029|Drug|MK0869, aprepitant|
5820810|NCT00042029|Drug|Comparator: placebo|
5820811|NCT00042016|Drug|decitabine (5-aza-2'deoxycytidine)|
5820812|NCT00042003|Drug|decitabine (5-aza-2'deoxycytidine)|
5820813|NCT00041990|Drug|decitabine (5-aza-2'deoxycytidine)|
5820814|NCT00041977|Drug|doxycycline hyclate 20 mg twice daily|
5820815|NCT00041938|Drug|aspirin|325 mg per day
5820816|NCT00041938|Drug|Warfarin|INR 2.5-3.0; target INR 2.75
5820817|NCT00041925|Drug|CGT003 (E2F Duplex Decoy)|
5820818|NCT00041860|Procedure|Controlled Exposure to Environmental Contaminant|
5820819|NCT00041821|Procedure|Nasal irritation thresholds and irritant provocation|
5820820|NCT00041899|Drug|CDB-2914|
5820821|NCT00041899|Drug|COB-2914|
5820822|NCT00041808|Drug|MTC-DOX for Injection|
5820823|NCT00041808|Procedure|Chemotherapy|
5820824|NCT00041795|Drug|leteprinim potassium (Neotrofin)|
5820825|NCT00041782|Drug|Dalteparin (Fragmin)|200 IU/kg subcutaneously daily (based on actual body weight with a maximum dose of 18,000 IU).
5820826|NCT00041769|Procedure|Therapeutic Drug Monitoring (TDM)|
5820827|NCT00041756|Drug|PG-530742|One 25 mg PG-530742 tablet, twice daily for for one year
5820828|NCT00041756|Drug|Placebo|One placebo tablet, twice daily for for one year
5820829|NCT00041756|Drug|50 mg PG-530742|One 50 mg PG-530742 tablet, twice daily for for one year
5820830|NCT00041756|Drug|100 mg PG-530742|100 mg PG-530742 tablet, twice a day for one year
5820831|NCT00041756|Drug|200 mg PG-530742|200 mg PG-530742 tablet, twice a day for one year
5820832|NCT00041743|Behavioral|Group Cognitive Behavioral Therapy|
5820833|NCT00041730|Biological|Id-KLH|
5820834|NCT00041717|Drug|Fampridine-SR|25mg bid (twice daily)
5820835|NCT00041717|Other|Placebo|Placebo
5820836|NCT00041704|Drug|Anidulafungin, VER002|
5820837|NCT00041691|Drug|hMN14 (labetuzumab)|
5820838|NCT00041678|Drug|aripiprazole|
5820839|NCT00041665|Drug|Recombinant Human Keratinocyte Growth Factor|
5820840|NCT00041652|Drug|hMN14 (labetuzumab)|
5820841|NCT00041639|Drug|hMN14 (labetuzumab)|
5820842|NCT00041626|Genetic|INGN 201|
5820843|NCT00041613|Genetic|INGN 201|
5820844|NCT00041587|Drug|IL13-PE38QQR|
5820845|NCT00041587|Procedure|targeted fusion protein therapy|
5820846|NCT00041587|Procedure|surgery|
5820847|NCT00041509|Drug|SB-424323|500 mg, oral, BID for 28 days or 125 mg, oral, BID for 28 days
5820848|NCT00041509|Drug|Placebo|matching placebo, oral, BID for 28 days
5820849|NCT00041496|Drug|SB-207266|White, oval, biconvex tablets containing either 10mg, 25mg or 40mg
5820850|NCT00041496|Other|Placebo|Placebo to match SB-207266
5820851|NCT00041574|Drug|Inhaled Nitric Oxide|Inhaled Nitric Oxide will be delivered through the INOpulse® at a Low Dose Range (3mL to 10mL; in 1mL increments) and Ultra Low Dose Ranges (0.5mL to 4mL; 0.5mL, then 1 to 4mL in 1mL increments).
5820852|NCT00041561|Drug|Nitrogen gas|Nitrogen gas will be given at 5ppm until Day 28 or extubation
5820853|NCT00041561|Drug|inhaled nitric oxide|inhaled nitric oxide will be given at 5 ppm until day 28 or extubation
5820854|NCT00041548|Drug|nitric oxide for inhalation|given at 20 ppm for 1 hour then weaned off over 4 hours
5820855|NCT00041548|Drug|Oxygen|given at 20 ppm for one hour, then weaned off over four hours
5820856|NCT00041535|Drug|OGT 918|
5820857|NCT00041470|Drug|Paclitaxel|50 mg/m2 IV weekly. Treatment continues until disease progression, excessive toxicity or other reason to remove the patient from protocol treatment.
5820936|NCT00040248|Drug|Daclizumab|
5820937|NCT00040235|Procedure|magnesium|
5820858|NCT00041470|Drug|Vinorelbine|20 mg/m2 IV weekly. Treatment continues until disease progression, excessive toxicity or other reason to remove the patient from protocol treatment.
5820859|NCT00041470|Drug|Herceptin|4 mg/kg IV loading dose day 1 of first week followed by 2 mg/kg IV maintenance dose on each subsequent week. Treatment continues until disease progression, excessive toxicity or other reason to remove the patient from protocol treatment.
5820860|NCT00041470|Drug|Filgrastim|5 mcg/kg daily including the day of IV chemotherapy. Treatment continues until disease progression, excessive toxicity or other reason to remove the patient from protocol treatment.
5820861|NCT00040677|Drug|Low Dose ICA-17043|Low dose arm
5820862|NCT00040677|Drug|High dose ICA-17043|150 mg Loading Dose; 10 mg daily dose
5820863|NCT00040677|Drug|Placebo|Placebo Loading dose capsules and maintenance dose tablets matched 10 mg active treatment group
5820864|NCT00040664|Drug|ritonavir|ritonavir oral capsules or oral solution
5820865|NCT00040664|Drug|fosamprenavir|fosamprenavir oral suspension or tablet
5820866|NCT00040651|Drug|Fludarabine|
5820867|NCT00040651|Drug|Cyclophosphamide|
5820868|NCT00040651|Drug|Thymoglobulin|
5820869|NCT00040651|Procedure|Leukapheresis|
5820870|NCT00040651|Procedure|Self bone marrow transplant|
5820871|NCT00041431|Drug|Hormone Replacement Therapy|
5820872|NCT00041392|Drug|Magnesium|100 mg/kg
5820873|NCT00041392|Drug|0.9% saline|Placebo
5820874|NCT00040638|Drug|TLK286|
5820875|NCT00040625|Drug|Pemetrexed|
5820876|NCT00040625|Drug|Cisplatin|
5820877|NCT00040027|Drug|thymalfasin (thymosin alpha 1) + PEGinterferon alfa-2a|
5820878|NCT00040027|Drug|placebo + PEGinterferon alfa-2a|
5820879|NCT00040599|Drug|hMN14 (labetuzumab)|
5820880|NCT00040586|Drug|Monoclonal Antibody J591|
5820881|NCT00040586|Drug|Recombinant Interleukin-2|
5820882|NCT00040573|Drug|131I-TM-601|
5820883|NCT00040560|Drug|111In-DAC|
5820884|NCT00040560|Procedure|Diagnostic|
5820885|NCT00040547|Drug|Farnesyl Protein Transferase Inhibitor|
5820886|NCT00040534|Drug|Farnesyl Protein Transferase Inhibitor|
5820887|NCT00040521|Drug|Recombinant Human Interleukin-11 (rhIL-11)|
5820888|NCT00040495|Drug|Pantoprazole|
5820889|NCT00040482|Drug|Cyclophosphamide|
5820890|NCT00040482|Drug|ATG|
5820891|NCT00040482|Drug|MESNA|
5820892|NCT00040482|Procedure|Radiation therapy|
5820893|NCT00040469|Drug|Campath -1H|
5820894|NCT00040469|Drug|Dilantin|
5820895|NCT00040469|Drug|Busulfan|
5820896|NCT00040469|Drug|Cyclophosphamide|
5820897|NCT00040456|Drug|Mg Pidolate|Mag 2 will be used (magnesium pidolate, a granular powder, containing 0.184 g of Mg/packet, equal to 7.6 mmol or 15.2 meq Mg), since this preparation has less side effects such as diarrhea than other Mg preparations. The study medication will be a liquid containing 0.6 meq Mg pidolate/kg body weight per day, divided into 2 daily doses. The Mg pidolate (45 g) will be distributed as a pre-mixed powder containing Koolaid Tropical Punch powder (9 gm), and sucrose (67 gm).
5820898|NCT00040456|Drug|Placebo|The study medication will be a liquid containing an equivalent amount of placebo to the study medication, divided into 2 daily doses.The placebo will have the same amount of sucrose and Tropical Punch powder as the study drug, MG Pidolate, as well as 45 g of lactose. Subjects will continue with the same assignment for 6 months and then switch to the other arm (after a 2-month wash-out period).
5820899|NCT00040443|Drug|CX516|
5820900|NCT00040443|Drug|Placebo|
5820901|NCT00040430|Drug|111In-DAC|
5820902|NCT00040430|Procedure|Diagnostic|
5820903|NCT00040508|Drug|Sirolimus|
5820904|NCT00040417|Drug|FLUDARABINE|
5820905|NCT00040417|Drug|CAMPATH-IH|
5820906|NCT00040417|Procedure|Total Body Irradiation|
5820907|NCT00040417|Drug|FK506|
5820908|NCT00040417|Drug|G-SCF (Granulocyte-colony stimulating factor)|
5820909|NCT00040404|Drug|CEP-1347 10mg|CEP-1347 10mg, a K252a derivative, retains neuroprotective properties
5820910|NCT00040404|Drug|CEP1347 25mg|CEP1347 25mg, a K252a derivative, retains neuroprotective properties
5820911|NCT00040404|Drug|CEP-1347 50mg|CEP-1347 50mg, a K252a derivative, retains neuroprotective properties
5820912|NCT00040404|Other|Placebo Comparator|Placebo capsules matching the CEP-1347 capsules
5820913|NCT00040391|Drug|Investigational drug|
5820914|NCT00040391|Drug|Irinotecan|
5820915|NCT00040391|Drug|5-fluorouracil|
5820916|NCT00040391|Drug|Leucovorin|
5820917|NCT00040378|Drug|alphatocopherol|400 IU daily
5820918|NCT00040378|Drug|Selenium|200mcg daily
5820919|NCT00040378|Drug|Placebo replacement for vitamin E|1 placebo pill daily
5820920|NCT00040378|Drug|Placebo replacement for Selenium|1 placebo pill daily
5820921|NCT00040365|Drug|Amifostine trihydrate|1000 mg for the first 18 patients. 2000 mg for the last 12 patients. The syringe of amifostine will be connected to a rectal enema bottle for administration. Administered slowly over 30-60 seconds with the patient in recumbent position 30-45 minutes prior to each radiation treatment (33-39 doses).
5820922|NCT00040365|Radiation|Radiation therapy|The treatment will be delivered in at least two phases. The first field reduction will occur after 46Gy and the second field reduction will occur after 70Gy.
5820923|NCT00040339|Procedure|hypothermia (body temperature lowered to 33°C or 91.4°F)|
5820924|NCT00040326|Procedure|anteromesial temporal resection|surgical treatment for epilepsy
5820925|NCT00040326|Drug|antiepileptic drugs|pharmacotherapy
5820926|NCT00040313|Drug|pegaptanib sodium (Macugen)|
5820927|NCT00040300|Drug|Racivir|
5820928|NCT00040287|Behavioral|smoking cessation program|
5820929|NCT00040287|Behavioral|weight control program|
5820930|NCT00040274|Drug|DPC 817|
5820931|NCT00040183|Drug|Tarceva (erlotinib HCl, OSI-774)|
5820932|NCT00040170|Biological|MVA-MUC1-IL2|
5820933|NCT00040157|Drug|ACH126-443 (Beta-L-Fd4C)|
5820934|NCT00040144|Drug|ACH126, 433 (b-L-Fd4C)|
5820935|NCT00040261|Drug|Memantine HCL|
5820942|NCT00040105|Drug|Zarnestra (R115777)|"Starting Dose:~300 mg by mouth (PO) Twice daily"
5820943|NCT00040105|Drug|Gleevec (Imatinib mesylate)|"Starting Dose:~300 mg By Mouth (PO) daily"
5820944|NCT00040092|Drug|Virulizin®|
5820945|NCT00040014|Drug|exemestane|
5820946|NCT00040001|Drug|DTI-0009|
5820947|NCT00039988|Drug|Glatiramer acetate|20 mg administered subcutaneously daily
5820948|NCT00039988|Drug|Albuterol|2 mg or 4 mg oral capsules taken daily
5820949|NCT00039988|Drug|Albuterol placebo|Oral placebo capsules will be taken daily
5820950|NCT00039975|Drug|Indinavir sulfate|
5820951|NCT00039975|Drug|Ritonavir|
5820952|NCT00039975|Drug|Amlodipine|
5820953|NCT00039975|Drug|Diltiazem HCl|
5820954|NCT00039962|Drug|thymalfasin (thymosin alpha 1)|
5820955|NCT00039962|Drug|PEGinterferon alfa-2a|
5820956|NCT00039936|Behavioral|Cognitive Behavior Treatment|
5820957|NCT00039936|Behavioral|Self Help|
5820958|NCT00039936|Behavioral|Partial Self Help|
5820959|NCT00040066|Procedure|Cocaine (IV)|
5820960|NCT00040053|Drug|Ondansetron|
5820961|NCT00040040|Drug|Bupropion|
5820962|NCT00039910|Drug|(PN-152,243)/ PN-196,444|
5820963|NCT00039884|Drug|NESP - Novel Erythropoiesis Stimulating Protein|
5820964|NCT00039871|Biological|PegIntron (peginterferon alfa-2b; SCH 54031)|PegIntron (peginterferon alfa-2b) administered at a dose of 1.5 mcg/kg subcutaneously (SC) once a week (QW) for up to 48 weeks
5820965|NCT00039871|Drug|REBETOL (ribavirin; SCH 18908)|REBETOL (ribavirin) administered on a weight basis: 800-1400 mg/day orally (PO) for up to 48 weeks
5820966|NCT00039858|Drug|Argatroban|
5820967|NCT00039832|Drug|Abciximab (ReoPro) and Reteplase (Retavase)|
5820968|NCT00039793|Procedure|Moderate-intensity and low-intensity bodywork therapy|
5820969|NCT00039780|Drug|BNP7787|The treatment regimen administered in this study is a single IV doxe of paclitaxel (80 mg/m2) +/- Herceptin given over 1 hour and either BNP7787 (18.4 g/m2) or placebo given over 45 minutes each week. One treatment cycle = 8 weeks.
5820970|NCT00039780|Drug|Placebo|The treatment regimen administered in this study is a single IV doxe of paclitaxel (80 mg/m2) +/- Herceptin given over 1 hour and either BNP7787 (18.4 g/m2) or placebo given over 45 minutes each week. One treatment cycle = 8 weeks.
5820971|NCT00039754|Drug|Holmium-166-DOTMP|
5820972|NCT00039741|Drug|NRTIs (ABC, FTC, FTC/TDF, 3TC, 3TC/AZT, d4T, TDF, ddC, AZT)|Accepted NRTIs: abacavir sulfate (ABC), emtricitabine (FTC), emtricitabine/Tenofovir disoproxil fumarate (FTC/TDF), lamivudine (3TC), lamivudine/zidovudine (3TC/AZT), stavudine (d4T), tenofovir disoproxil fumarate (TDF), zalcitabine (ddC), zidovudine (AZT) Prescribed per participant's doctor
5820973|NCT00039741|Drug|NNRTIs (EFV, NVP)|"Accepted NNRTIs: efavirenz (EFV), nevirapine (NVP)~Prescribed per participant's doctor"
5820974|NCT00039741|Drug|PIs (AMP, IDV, LPV/r, NFV, SQV, RTV)|"Accepted PIs: amprenavir (APV). indinavir sulfate (IDV), lopinavir/ritonavir (LPV/r), nelfinavir mesylate (NFV), saquinavir (SQV), ritonavir (RTV)~Prescribed per participant's doctor"
5820975|NCT00039767|Drug|Lepirudin|
5820976|NCT00039026|Drug|AC2993|Placebo Lead In (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 26 weeks - All are subcutaneously injected twice daily
5820977|NCT00039026|Drug|AC2993|Placebo Lead In (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 26 weeks - All are subcutaneously injected twice daily
5820978|NCT00039026|Drug|Placebo|Placebo Lead In (0.02 mL) for 4 weeks / Placebo (0.02 mL) for 4 weeks / Placebo (0.02 mL) for 26 weeks - All are subcutaneously injected twice daily
5820979|NCT00039026|Drug|Placebo|Placebo Lead In (0.02 mL) for 4 weeks / Placebo mcg (0.02 mL) for 4 weeks / Placebo (0.04 mL) for 26 weeks - All are subcutaneously injected twice daily
5820980|NCT00039013|Drug|AC2993|Placebo Lead In (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 26 weeks - All are subcutaneously injected twice daily
5820981|NCT00039013|Drug|AC2993|Placebo Lead In (0.02 mL) for 4 weeks / AC2993 5 mcg (0.02 mL) for 4 weeks / AC2993 10 mcg (0.04 mL) for 26 weeks - All are subcutaneously injected twice daily
5820982|NCT00039013|Drug|Placebo|Placebo Lead In (0.02 mL) for 4 weeks / Placebo (0.02 mL) for 4 weeks / Placebo (0.02 mL) for 26 weeks - All are subcutaneously injected twice daily
5820983|NCT00039013|Drug|Placebo|Placebo Lead In (0.02 mL) for 4 weeks / Placebo mcg (0.02 mL) for 4 weeks / Placebo (0.04 mL) for 26 weeks - All are subcutaneously injected twice daily
5820984|NCT00039000|Drug|HSPPC-96 or Oncophage|
5820985|NCT00038987|Biological|Wetvax (APSV)|
5820986|NCT00038974|Drug|peginterferon alfa-2a|
5820987|NCT00038974|Drug|Ribavirin|
5820988|NCT00038961|Drug|fondaparinux sodium|2.5 mg fondparinux sodium, daily, s.c. starting 6 to 8 hours after surgical closure for up to 7 +/- 2 days, administered on top of IPC +/- elastic stockings (ES)
5820989|NCT00038961|Other|placebo|placebo, daily, s.c. starting 6 to 8 hours after surgical closure for up to 7 +/- 2 days, administered on top of IPC +/- elastic stockings (ES)
5820990|NCT00039702|Drug|[123] 5-I-A-85380|
5820991|NCT00039663|Drug|Pravastatin|
5820992|NCT00039663|Drug|Gemfibrozil|
5820993|NCT00039663|Drug|Rosiglitazone|
5820994|NCT00039624|Radiation|Brachytherapy|Patients will receive two HDR brachytherapy implants (950-1050 cGy/implant) before and at the end of a course of external beam radiotherapy (4600 cGy, 2Gy/day).
5820995|NCT00038948|Drug|Sirolimus|Sirolimus, Cyclosporine A & Tacrolimus are concentration controlled
5820996|NCT00038948|Drug|tacrolimus|
5820997|NCT00038948|Drug|Cyclosporine A|
5820998|NCT00038935|Drug|ReFacto AF|
5820999|NCT00038922|Drug|rhIL-11|
5821000|NCT00038909|Drug|BDDrFVII|
5821001|NCT00038896|Drug|Venlafaxine ER|
5821002|NCT00038883|Drug|Campath-1H|10 mg/day x 5, starting with the first day of chemotherapy
5821003|NCT00038870|Biological|Dendritic Cell Activated Lymphocyte|
5821004|NCT00038857|Procedure|Megadose of CD34 Selected Progenitor Cells|Haploidentical peripheral blood progenitor cell (PBPC) transplants on Day 0.
5821005|NCT00038857|Drug|Melphalan|140 mg/m^2 on day -8
5821006|NCT00038857|Drug|Thiotepa|10 mg/kg on day -7
5822967|NCT00002064|Drug|Pyrimethamine|
5821007|NCT00038857|Drug|Fludarabine|160 mg/m^2 over 4 days on days -6, -5, -4, -3
5821008|NCT00038857|Drug|Rabbit ATG|1.5 mg/kg of Rabbit ATG a day times 4 over 4 days on days -6, -5, -4, -3.
5821009|NCT00038844|Drug|Campath-1 H (Alemtuzumab)|Starting Dose of 15 mg by vein daily, 3 days in a row.
5821010|NCT00038844|Drug|Fludarabine|30 mg/m2 by vein daily, 3 days in a row.
5821011|NCT00038844|Drug|Cyclophosphamide|1 gm/m2 by vein daily, 3 days in a row.
5821012|NCT00038844|Drug|Rituximab|375 mg/m2 by vein, given (to some patients only, based on the subtypes of lymphomas) eight days before the transplant and then weekly for a total of 4 doses.
5821013|NCT00038831|Drug|Mylotarg|Starting dose 2 mg/m^2 over 2-hour intravenous infusion on day -12.
5821014|NCT00038831|Drug|Fludarabine|30 mg/m^2 will be given intravenously daily at the same time over 30 minutes on days -5, -4, -3, -2.
5821015|NCT00038831|Drug|Melphalan|140 mg/m^2 will be given intravenously over 20 minutes starting 2 hours after the beginning of the fludarabine infusion on day -2.
5821016|NCT00038831|Drug|Anti-thymocyte globulin|Patients with an unrelated or mismatched related donor will receive 0.5 mg/kg on day -3 and 1.25 mg/Kg on days -2 and -1, following the chemotherapy.
5821017|NCT00038831|Procedure|Stem cell transplant|Allogeneic Bone Marrow and Peripheral Blood Stem Cell Transplantation: Infusion of blood stem cells or bone marrow cells on day 0.
5821018|NCT00038818|Biological|CD8 Depleted Donor Lymphocyte|
5821019|NCT00038805|Drug|Mylotarg|
5821020|NCT00038792|Drug|Recombinant Human Keratinocyte Growth Factor|
5821021|NCT00038779|Procedure|Megadose T-cell Depleted HLA-nonidentical Blood Progenitor Cell Transplantation|
5821022|NCT00038766|Drug|semapimod|semapipmod 60 mg IV x 5 days
5821023|NCT00038766|Drug|semapimod|IV 30 mg x 5 days
5821024|NCT00038766|Drug|placebo|placebo IV
5821025|NCT00038753|Procedure|Vision Screening|
5821026|NCT00038727|Behavioral|DPPOS Group Lifestyle|Quarterly group lifestyle sessions
5821027|NCT00038727|Drug|Metformin|Administered as 850mg twice per day, masked in DPP and open label in DPPOS
5821028|NCT00038727|Behavioral|DPPOS Boost Lifestyle|In addition to quarterly group, 2 additional classes per year and an annual 15 minute check-up.
5821029|NCT00038727|Behavioral|Intensive Lifestyle Group Session|16 session curriculum in group format. In DPP delivered to ILS as individual sessions
5821030|NCT00038714|Drug|SGN-00101|
5821031|NCT00038701|Drug|TNP-470|
5821032|NCT00038688|Behavioral|Peer HIV Education Program|
5821033|NCT00038675|Drug|Imatinib Mesylate (Gleevec)|Imatinib mesylate 400 mg orally daily, and in HES patients start with imatinib mesylate 100 mg orally daily
5821034|NCT00038662|Drug|Atrasentan|
5821035|NCT00038649|Drug|Gleevec|400 mg orally twice daily
5821036|NCT00038636|Drug|Lopinavir/ritonavir|
5821037|NCT00038636|Drug|Ritonavir|
5821038|NCT00038623|Drug|Yttrium-ibritumomab (Zevalin)|After Rituximab infusion, 111^In Zevalin on Day 1 followed by two whole body imaging performed on Day 1 then Day 2.
5821039|NCT00038623|Drug|Rituximab|250 mg/m^2 in the vein over 6 to 8 hours on Day 1.
5821040|NCT00038610|Drug|Imatinib Mesylate|600 mg by mouth on days 1 - 14 for course 1, and 600 mg by mouth daily days 1-14 (or daily if tolerated with course 1) for courses 2, 4, 6, 8.
5821041|NCT00038610|Drug|Cyclophosphamide|300 mg/m^2 by vein every 12 hours for 6 doses days 1, 2, 3 (total dose 1800 mg/m^2) for courses 1, 3, 5, 7.
5821042|NCT00038610|Drug|Doxorubicin|50 mg/m^2 by vein on day 4 after last dose of CTX for courses 1, 3, 5, 7.
5821043|NCT00038610|Drug|Vincristine|2 mg by vein on day 4 and day 11 for courses 1, 3, 5, 7.
5821044|NCT00038610|Drug|Dexamethasone|40 mg by vein or by mouth daily on days 1 - 4 and days 11 - 14 for courses 1, 3, 5, 7.
5821045|NCT00038610|Drug|Methotrexate|"12 mg intrathecally (6 mg if via Ommaya reservoir) day 2 for courses 1, 3, 5, 7.~200 mg/m^2 by vein over 2 hours followed by 800 mg/m^2 over 22 hours on day 1 of courses 2, 4, 6, 8."
5821046|NCT00038610|Drug|Cytarabine|"100 mg intrathecally day 7 for courses 1, 3, 5, 7.~3 gm/m2 by vein over 2 hrs every 12 hrs for 4 doses on days 2 and 3 for courses 2, 4, 6, 8."
5821047|NCT00038610|Drug|Mesna|600 mg/m^2 by vein daily for 24 hours for courses 1, 3, 5, 7.
5821048|NCT00038610|Drug|G-CSF|10 mcg/kg/day after completion of chemotherapy until neutrophil recovery to 1 x 109/L or higher for all courses.
5821049|NCT00038597|Drug|SCH66336|
5821050|NCT00038584|Drug|SCH66336|
5821051|NCT00038571|Drug|PS341 (Bortezomib)|1.5 mg/m2 intravenous (IV) bolus push over 3 to 5 seconds on days 1, 4, 8, and 11, followed by a 10-day rest for a 21-day cycle.
5821052|NCT00038558|Drug|Filgrastim SD/01|
5821053|NCT00038558|Drug|Adriamycin|
5821054|NCT00038558|Drug|Bleomycin|
5821055|NCT00038558|Drug|Vinblastine|
5821056|NCT00038558|Drug|DTIC|
5821057|NCT00038545|Drug|Filgrastim SD/01|
5821058|NCT00038545|Drug|Paclitaxel|
5821059|NCT00038545|Drug|Topotecan|
5821060|NCT00038532|Drug|Amprenavir/ritonavir|
5821061|NCT00038532|Drug|Saquinavir/ritonavir|
5821062|NCT00038532|Drug|Efavirenz|
5821063|NCT00038519|Drug|Amprenavir/ritonavir|
5821064|NCT00038519|Drug|Saquinavir/ritonavir|
5821065|NCT00038506|Drug|abacavir/lamivudine/zidovudine|
5821066|NCT00038506|Drug|tenofovir|
5821067|NCT00038493|Drug|Temozolomide and SCH66336|
5821068|NCT00038480|Drug|Lopinavir/Ritonavir|
5821069|NCT00038467|Drug|Tamoxifen|Tamoxifen 20 mg/day tablets administered p.o. for a period ranging from 2.5 to 3 years.
5821070|NCT00038467|Drug|Exemestane|Exemestane 25 mg/day tablets administered p.o. for a period ranging from 2.5 to 3 years.
5821071|NCT00038454|Drug|Hemolink (hemoglobin raffimer IV solution)|
5821072|NCT00038441|Drug|DTI-015|DTI-015 injected through a catheter into center of brain tumor.
5821073|NCT00038428|Drug|TLK286|
5821074|NCT00038415|Biological|CLL vaccine using DNA plasmid vector|
5821075|NCT00038402|Drug|Herceptin|Starting dose of 4 mg/kg by vein, then 2 mg/kg weekly after that until the end of all cycles of neo-adjuvant chemotherapy and during FEC therapy for a total of 24 doses.
5821144|NCT00037921|Procedure|Bacterial colonization|
5821076|NCT00038402|Drug|Taxol|225 mg/m^2 by vein as a continuous infusion over 24 hours each cycle for a total of 4 cycles.
5821077|NCT00038402|Drug|Fluorouracil|500 mg/m^2 by vein on Days 1 and 4 for 4 cycles at 3-4 week intervals.
5821078|NCT00038402|Drug|Cytoxan|500 mg/m^2 on Day 1 of each cycle for 4 cycles.
5821079|NCT00038402|Drug|Epirubicin|75 mg/m^2 IV on Day 1 of each cycle for 4 cycles.
5821080|NCT00038389|Drug|Vioxx|Starting dose for patients age 3-14 years 10.0 mg/1.73 m2 and for patients above 14 years of age 12.5 mg for 5 days per week for 6 weeks during radiation treatment, and 7 days per week for 6 months after radiation treatment.
5821081|NCT00038376|Drug|Isotretinoin (Accutane)|0.5 mg/k (1.0 mg/k total) by mouth twice a day
5821082|NCT00038376|Drug|Interferon Alpha|Starting dose of 3 MU injected under skin once a day for 12 weeks.
5821083|NCT00038363|Procedure|Rehabilitation|
5821084|NCT00038363|Procedure|Subacute care|
5821085|NCT00038350|Behavioral|Lingual Strengthening|8 week lingual strengthening exercise protocol
5821086|NCT00038337|Procedure|Health Literacy|
5821087|NCT00038311|Drug|PN-152,243)/PN-196,444|
5821088|NCT00038298|Drug|Placebo|Placebo given 3 times weekly
5821089|NCT00038298|Drug|AMG 719|50 mg 3 times weekly
5821090|NCT00038298|Drug|AGM 719|200 mg 3 times weekly
5821091|NCT00038298|Drug|AMG 719|400 mg 3 times weekly
5821092|NCT00038298|Drug|placebo to AMG 719|Placebo dose given 3 times weekly
5821093|NCT00038285|Procedure|Amputation Prevention|
5821094|NCT00038272|Drug|Mycophenolate mofetil|
5821095|NCT00038272|Drug|Amdoxovir|
5821096|NCT00038259|Drug|Aldesleukin|
5821097|NCT00038246|Drug|Estramustine|140 mg by mouth (po) three times a day on Days 1-5, 8-12
5821098|NCT00038246|Drug|Thalidomide|200 mg by mouth every day once a week with dose escalation every week if no dose limiting toxicity.
5821099|NCT00038246|Drug|Paclitaxel (Taxol)|100 mg/m^2 by vein (IV) over 3 hours Day 3 and Day 10
5821100|NCT00038233|Drug|Thalidomide|200 mg at bedtime daily for 14 days (days 1-14), followed by an increase to 400 mg daily for 14 days (days 15-28), 600 mg daily for 14 days (days 29-42), up to a maximum 800 mg (days 43-completion)
5821101|NCT00038220|Drug|Lopinavir/ritonavir|
5821102|NCT00038220|Drug|Efavirenz|
5821103|NCT00038220|Drug|Lamivudine|
5821104|NCT00038220|Drug|Tenofovir DF|
5821105|NCT00038207|Drug|Liposomal Vincristine|Vincristine Sulfate Liposome Injection (VSLI) administered via a central venous catheter at 2.0 mg/m2 over 60 minutes every 14 days + 2 days
5821106|NCT00038194|Drug|imatinib mesylate|
5821107|NCT00038194|Drug|docetaxel|
5821108|NCT00038181|Drug|Thalidomide|
5821109|NCT00038168|Drug|Estramustine|Intravenous dose
5821110|NCT00038168|Drug|Taxol|Intravenous dose
5821111|NCT00038155|Procedure|Ambulation training|Recruitment of eligible subjects, ambulatory and resistance training in hospital and post-discharge
5821112|NCT00038142|Drug|Vincristine|2.0 mg/m^2 (max 2.0 mg) IV x 1 repeated every 3 weeks X 6.
5821113|NCT00038142|Drug|Doxorubicin|90 mg/m^2 IV over 30 min x 1 repeated every 3 weeks X 6.
5821114|NCT00038142|Drug|Cyclophosphamide|2.0 g/m^2 IV daily x 2 days repeated every 3 weeks X 6.
5821115|NCT00038142|Drug|Dexrazoxane|900 mg/m^2 IV (30 min prior to doxorubicin) repeated every 3 weeks X 6.
5821116|NCT00038142|Biological|ImmTher|900 mcg/m^2 IV over 1 hour every week x 50-52 weeks.
5821117|NCT00038129|Procedure|Intramedullary nail implant|Insertion of an intramedullary nail during tibial fracture fixation with or without prior reaming of the intramedullary canal.
5821118|NCT00038116|Procedure|embryonic dopamine cell implant surgery|Half of the participants received the cell implant surgery, while the other half received the placebo. After the double-blind phase of the study, patients in the placebo group had the option of receiving tissue implants. Fourteen of these patients eventually had transplants.
5821119|NCT00038116|Procedure|placebo|sham surgery
5821120|NCT00038103|Drug|Exemestane|Patient will be instructed to take a 25 mg exemestane tablet, once a day, every day, with food.
5821121|NCT00038103|Drug|Celecoxib + Exemestane|Exemestane + celecoxib treatment arm, she will be instructed to take also two x 200 mg celecoxib capsules twice a day, every day, with food.
5821122|NCT00038090|Drug|Thalidomide|100 mg capsules by mouth daily each evening
5821123|NCT00038090|Drug|Dexamethasone|20 mg/m^2 taken by mouth each morning on days 1-4, 9-12 and 17-20.
5821124|NCT00038077|Drug|Seloken ZOK/Toprol-XL|50 mg
5821125|NCT00038077|Drug|Seloken ZOK/Toprol-XL|200 mg
5821126|NCT00038077|Drug|Placebo|
5821127|NCT00038064|Drug|Darbepoetin alfa|Darbepoetin alfa will be administered 4.5 mcg/kg QW until hemoglobin correction is achieved. Subjects meeting hemoglobin criteria for correction will receive a maintenance dose of darbepoetin alfa of 4.5 mcg/kg Q3W.
5821128|NCT00038064|Drug|rHuEPO|150 IU/kg TIW
5821129|NCT00038051|Drug|Hum-195/rGel|Starting Dose = 3 mg/m^2 twice weekly for 2 weeks.
5821130|NCT00038038|Drug|18F-fluoromisonidazole|Small amount of radioactive traces drug given by intravenous injection prior to PET Scan
5821131|NCT00038038|Procedure|PET scan|Series of pictures using 20 minute scan performed 2 hours after an 18F-fluoromisonidazole injection
5821132|NCT00038025|Drug|Deoxycoformycin (DCF)|Patients received Deoxycoformycin (DCF)/Pentostatin administered by intravenous bolus daily over a consecutive 3-day period. This course was repeated at 3-week intervals.
5821133|NCT00038012|Drug|Thrombopoietin|
5821134|NCT00038012|Procedure|Platelet-pheresis|
5821135|NCT00038012|Drug|Carboplatin|
5821136|NCT00037999|Procedure|Testosterone supplement|
5821137|NCT00037986|Device|Hearing Aids|Hearing aid use
5821138|NCT00037973|Behavioral|ventilation feedback|
5821139|NCT00037973|Behavioral|exercise|
5821140|NCT00037960|Procedure|Constrained Induced Therapy|
5821141|NCT00037947|Procedure|Hearing in Multiple Sclerosis|
5821142|NCT00037934|Device|Upper extremity robot|Robotic upper extremity neuro-rehabilitation
5821143|NCT00037934|Other|Traditional Supervised Upper Extremity Exercises|Arm ergometer, reaching, and stretching exercises
5821237|NCT00036413|Drug|TCH346|
5821145|NCT00037908|Procedure|Strength training|
5821146|NCT00037895|Procedure|Ambulation training|
5821147|NCT00037882|Drug|PEG-Intron|Once weekly injection.
5821148|NCT00037869|Drug|I-131 Metaiodobenzylguanidine|
5821149|NCT00037843|Drug|I-131 Iodocholesterol|
5821150|NCT00037830|Drug|GM1 ganglioside|100 mg twice per day by subcutaneous injection
5821151|NCT00037830|Drug|Placebo|Twice per day subcutaneous injection, equal volume as active drug
5821152|NCT00037817|Drug|Decitabine|assigned dose level on day 4 and day 10 of each 34 day cycle
5821153|NCT00037817|Biological|Depsipeptide|assigned dose level on day 4 and day 10 of each 34 day cycle
5821154|NCT00037817|Drug|Celecoxib|400mg PO BID on days 4 through 34 of each cycle
5821155|NCT00037804|Drug|Irinotecan|
5821156|NCT00037791|Drug|(PN-152,243)/PN-196,444|
5821157|NCT00004575|Drug|Miconazole, L-NMMA, Bradykinin|
5821158|NCT00001866|Procedure|horizontal muscles of the eye will be cut and then reattached in the same position|
5821159|NCT00001864|Drug|Atropine|
5821160|NCT00001864|Device|Patch|
5821161|NCT00001818|Drug|Hydroxyurea|
5821162|NCT00001688|Drug|Ritonavir|
5821163|NCT00001688|Drug|Nevirapine|
5821164|NCT00001688|Drug|Stavudine|
5821165|NCT00001542|Drug|fluconazole|
5821166|NCT00001190|Drug|Deslorelin|
5821167|NCT00037752|Drug|Sibutramine|At the baseline study visit, participants in Group 1 will be given a one month supply of 5 mg/d of sibutramine and a 1-month follow-up visit will be scheduled. After a safety evaluation at the 1-month follow-up visit, participants will have their dose of sibutramine titrated to 10 mg/d, a 1 month supply of the medication will be given to participants, and a 2-month follow-up visit will be scheduled. After a safety evaluation at the 2-month follow-up visit, participants will receive a 1 month supply of sibutramine 10 mg/d and a 3-month follow-up visit will be scheduled. At the 3-month follow-up visit, the sibutramine will be discontinued and participants will be scheduled for 4- and 5-month follow-up visits.
5821168|NCT00037752|Behavioral|Behavioral Smoking Cessation Program|Both groups of participants will take part in a behavioral smoking cessation program.
5821169|NCT00037713|Biological|BEC2 Vaccine|5 vaccinations of BEC2 (2.5 mg) + BCG given day 1 of weeks 0,2,4,6 & 10.
5821170|NCT00037700|Drug|anakinra|
5821171|NCT00037700|Drug|pegsunercept|
5821172|NCT00037687|Drug|rPAF-AH|
5821173|NCT00037674|Drug|Topiramate|
5821174|NCT00037661|Drug|INS365 Ophthalmic Solution|
5821175|NCT00037648|Drug|Anakinra|anakinra
5821176|NCT00037648|Drug|Placebo|placebo
5821177|NCT00037635|Drug|AMG 073|30 mg QD orally 60 mg QD orally 90 mg QD orally 120 mg QD orally 180 mg QD orally
5821178|NCT00037635|Drug|Placebo|30 mg QD orally 60 mg QD orally 90 mg QD orally 120 mg QD orally 180 mg QD orally
5821179|NCT00037622|Drug|ACH-126, 443 (beta-L-Fd4C)|
5821180|NCT00037609|Drug|Capecitabine|1000 mg/m^2 taken by mouth twice daily.
5821181|NCT00037609|Drug|Exisulind|125 mg taken by mouth twice daily.
5821182|NCT00037596|Drug|Gemtuzumab Ozogamicin|
5821183|NCT00037596|Drug|cytarabine.|
5821184|NCT00037583|Drug|Gemtuzumab Ozogamicin|
5821185|NCT00037570|Drug|Pantoprazole|
5821186|NCT00037557|Drug|BeneFIX|
5821187|NCT00037544|Drug|ReFacto AF|
5821188|NCT00037531|Drug|Sirolimus (RAPAMUNE)|
5821189|NCT00037518|Drug|AMG 073|
5821190|NCT00037492|Procedure|home-based sessions/family meetings with trained clinician|
5821191|NCT00037479|Drug|ceftriaxone|
5821192|NCT00037440|Genetic|Polymorphisms measured|
5821193|NCT00037219|Drug|Anidulafungin, VER002|
5821194|NCT00037206|Drug|Anidulafungin, VER002|
5821195|NCT00037180|Drug|Celecoxib|
5821196|NCT00037180|Drug|Irinotecan|
5821197|NCT00037180|Drug|5-fluorouracil|
5821198|NCT00037180|Drug|Leucovorin|
5821199|NCT00037167|Device|Exercise poles|
5821200|NCT00037154|Drug|Saw Palmetto|
5821201|NCT00037141|Drug|dehydrated alcohol|
5821202|NCT00037128|Drug|GL701|
5821203|NCT00037115|Drug|interferon beta 1a|
5821204|NCT00037115|Drug|methotrexate|
5821205|NCT00037115|Drug|methylprednisolone|
5821206|NCT00037102|Drug|interferon beta 1a|
5821207|NCT00037102|Drug|methotrexate|
5821208|NCT00037089|Drug|UFT (Tegafur/Uracil)|
5821209|NCT00037063|Drug|Thiamine hydrochloride|
5821210|NCT00037063|Drug|Riboflavin|
5821211|NCT00037063|Drug|Ascorbic acid|
5821212|NCT00037063|Drug|Vitamin E|
5821213|NCT00037050|Drug|Linezolid|
5821214|NCT00037050|Drug|Vancomycin|
5821215|NCT00037050|Drug|Oxacillin|
5821216|NCT00037050|Drug|Dicloxacillin|
5821217|NCT00036647|Drug|Tarceva (erlotinib HCl, OSI-774 )|
5821218|NCT00036634|Drug|Tenofovir DF|Tenofovir DF tablet administered orally once daily
5821219|NCT00036634|Drug|Tenofovir alafenamide|Tenofovir alafenamide tablet(s) administered orally once daily
5821220|NCT00036621|Drug|BMS-275291|
5821221|NCT00036608|Drug|Entecavir|
5821222|NCT00036582|Drug|Clozapine|
5821223|NCT00036569|Procedure|adjuvant therapy|
5821224|NCT00036569|Biological|pegylated interferon alfa|0.3 mg/kg subcutaneously once a week for 4 weeks beginning 2-10 weeks after completion of radiation therapy and continued until disease progression or one of the other off study criteria.
5821225|NCT00036556|Drug|Atrasentan|
5821226|NCT00036543|Drug|Atrasentan|
5821227|NCT00036517|Drug|PHY906|
5821228|NCT00036504|Drug|Insulin Lispro low mixture|
5821229|NCT00036491|Drug|Rituximab|Subjects received four weekly infusions of rituximab at a dose of 375 mg/m^2
5821230|NCT00036465|Behavioral|Treatment regimen change|
5821231|NCT00036452|Drug|lopinavir/ritonavir|
5821232|NCT00036452|Drug|emtricitabine|
5821233|NCT00036452|Drug|stavudine|
5821234|NCT00036452|Drug|tenofovir DF|
5821235|NCT00036439|Drug|Infliximab|
5821236|NCT00036426|Biological|FavId (Id-KLH) active immunotherapy|
5821243|NCT00036335|Drug|Duloxetine Hydrochloride|
5821244|NCT00036309|Drug|Duloxetine Hydrochloride|
5821245|NCT00036296|Drug|talampanel|75mg per day divided into 3 doses for 22 days
5821246|NCT00036283|Drug|Celecoxib|
5821247|NCT00036270|Drug|exemestane (Aromasin)|exemestane, orally, 25 mg, for 5 years
5821248|NCT00036270|Drug|tamoxifen + exemestane|tamoxifen, 20 mg, orally, daily, 2-3 years; followed by exemestane, orally, 25 mg, for a total of 5 years of therapy
5821249|NCT00036257|Drug|CP-461|
5821250|NCT00036244|Drug|RG1068 (Synthetic Human Secretin)|
5821251|NCT00036231|Drug|RG1068 (Synthetic Human Secretin)|
5821252|NCT00036218|Drug|sumanirole|
5821253|NCT00036218|Drug|ropinirole|
5821254|NCT00036205|Drug|sumanirole|
5821255|NCT00036192|Drug|FK614|
5821256|NCT00036179|Drug|FK463|
5821257|NCT00036166|Drug|FK463|
5821258|NCT00036153|Drug|Tacrolimus (Prograf®)|
5821259|NCT00036153|Drug|Methotrexate|
5821260|NCT00036140|Drug|Investigational drug|
5821261|NCT00036127|Drug|aripiprazole|
5821262|NCT00036114|Drug|aripiprazole|
5821263|NCT00036101|Drug|aripiprazole|
5821264|NCT00036088|Drug|Olanzapine|
5821265|NCT00036075|Drug|CP-461|
5821266|NCT00036062|Drug|Sivelestat|
5821267|NCT00036036|Drug|CP-461|
5821268|NCT00036023|Drug|darbepoetin alfa|
5821269|NCT00035997|Drug|Zometa|
5821270|NCT00035984|Drug|AC2993|Placebo Lead In (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 26 weeks - All are subcutaneously injected twice daily
5821271|NCT00035984|Drug|AC2993|Placebo Lead In (0.02 mL) for 4 weeks / AC2993 5 mcg (0.02 mL) for 4 weeks / AC2993 10 mcg (0.04 mL) for 26 weeks - All are subcutaneously injected twice daily
5821272|NCT00035984|Drug|Placebo|Placebo Lead In (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 4 weeks / AC2993 5mcg (0.02 mL) for 26 weeks - All are subcutaneously injected twice daily
5821273|NCT00035984|Drug|Placebo|Placebo Lead In (0.02 mL) for 4 weeks / Placebo mcg (0.02 mL) for 4 weeks / Placebo (0.04 mL) for 26 weeks - All are subcutaneously injected twice daily
5821274|NCT00035971|Drug|raloxifene HCI and alendronate Na|
5821275|NCT00035958|Drug|Prednisone|
5821276|NCT00035958|Drug|Methotrexate|
5821277|NCT00035958|Drug|Etanercept|
5821278|NCT00035945|Drug|ISIS 14803|
5821279|NCT00035932|Drug|Atazanavir + ritonavir + tenofovir + nucleoside|Active Comparator, Capsules, tablets, Oral
5821280|NCT00035932|Drug|Atazanavir + saquinavir + tenofovir + nucleoside|Active Comparator, Capsules, tablets, Oral
5821281|NCT00035932|Drug|Lopinavir/ritonavir + tenofovir + nucleoside|Active Comparator, Capsules, tablets, Oral
5821282|NCT00035919|Genetic|Mx-dnG1 Retroviral Vector|
5821283|NCT00035906|Drug|DEX PS DDS®|
5821284|NCT00035893|Drug|poly I-poly C12U|200-400 mg IV infusions 2x/week for 64 weeks
5821285|NCT00035880|Drug|ABX-CBL|
5821286|NCT00035867|Drug|TLK199 HCl Liposomes for Injection|
5821287|NCT00035854|Drug|Zyvox® / Linezolid|
5821288|NCT00035841|Drug|TLK286|
5821289|NCT00035828|Drug|ABX-IL8|
5821290|NCT00035815|Drug|Insulin like growth factor, type 1|0.05 mg per kg body weight given subcutaneously twice daily
5821291|NCT00035815|Drug|Placebo|The placebo represented the inert suspension vehicle for the IGF-1. It was given as equal volume as the active drug based upon body weight, subcutaneously twice daily.
5821292|NCT00035802|Drug|Topiramate|"Double-blind period: Up to 400 mg/day (two 100-mg tablets twice a day) for 28 days.~OL period: Up to 600 mg/day (three 100-mg tablets twice a day) for at least 6 months."
5821293|NCT00035802|Drug|Placebo|Double-blind period: Equal number of matching placebo tablets for each of the topiramate tablet strengths twice a day for 28 days.
5821294|NCT00035789|Drug|Entecavir|
5821295|NCT00035633|Drug|Entecavir|
5821296|NCT00035620|Drug|pegfilgrastim|pegfilgrastim
5821297|NCT00035620|Drug|filgrastim|filgrastim
5821298|NCT00035607|Drug|Darbepoetin alfa SC|Subcutaneous (SC) injection of darbepoetin alfa at 4.5 mcg/kg weekly for weeks 1-6, then 4.5 mcg/kg Q3W
5821299|NCT00035607|Drug|Darbepoetin alfa IV|Intravenous administration of darbepoetin alfa at 4.5 mcg/kg weekly for weeks 1-6, then 4.5 mcg/kg Q3W
5821300|NCT00035594|Drug|pegfilgrastim|Growth factor (GCSF) administered to promote neutrophil development post-chemotherapy.
5821301|NCT00035581|Drug|poly I-poly C12U|200-400 mg IV infusions 2x/week for 24 weeks
5821302|NCT00035568|Drug|Glucovance (metformin HCl/glyburide)|
5821303|NCT00035568|Drug|or Metformin HCl alone|
5821304|NCT00035568|Drug|or Glyburide alone.|
5821305|NCT00035555|Drug|Belatacept|Solution, intravenous
5821306|NCT00035555|Drug|Cyclosporine|Oral, capsule
5821307|NCT00035555|Drug|Mycophenolate mofetil (MMF)|Oral, capsule
5821308|NCT00035555|Drug|Corticosteroids|Corticosteroids given daily, orally or intravenously (IV). Day of transplant (Day 1): methylprednisolone, 500 mg, given IV on arrival in operating room; Day 2: methylprednisolone, 250 mg, given IV once daily; Day 3: prednisone, 100 mg, given orally once daily; Day 4: prednisone, 50 mg, given orally once daily; Days 5 through 30: prednisone, 25 mg, given orally once daily; Days 31-44: prednisone, 22.5 mg, given orally once daily; Days 45-58: prednisone, 20 mg, given orally once daily
5821309|NCT00035542|Drug|Glucovance (metformin HCl/glyburide)|
5821310|NCT00035542|Drug|metformin HCl|
5821311|NCT00035542|Drug|glyburide|
5821312|NCT00035529|Drug|Placebo|Solution, i.v infusion, 0 mg, Days 1 & 15 then monthly, 10 months.
5821313|NCT00035529|Drug|BMS 188667 (Abatacept)|Vial, i.v infusion, 2mg/kg, Days 1 & 15 then monthly, 10 months.
5821314|NCT00035529|Drug|BMS 188667 (Abatacept)|Vial, i.v infusion, 10 mg/kg, Days 1 & 15 then monthly, 10 months.
5821315|NCT00035516|Drug|Epothilone|
5821316|NCT00035503|Drug|etiprednol dicloacetate|
5821317|NCT00035490|Drug|Azimilide Dihydrochloride|125 mg azimilide, once a day for one year
5821318|NCT00035490|Drug|placebo|placebo tablet, once daily for one year
5821319|NCT00035490|Drug|Azimilide Dihydrochloride|75 mg azimilide, once a day for one year
5821320|NCT00035477|Drug|Azimilide Dihydrochloride|125 mg azimilide tablets once a day for 3 days in hospital and 125 mg azimilide tablets once a day for 6 months as outpatient
5821321|NCT00035477|Drug|Placebo|placebo tablets once a day for 3 days in hospital and placebo tablets once a day for 6 months as outpatient
5821322|NCT00035464|Drug|Azimilide Dihydrochloride|125 mg azimilide tablets, twice a day for 6 months
5821323|NCT00035464|Drug|Placebo|placebo tablets, twice a day for 6 months
5821324|NCT00035451|Drug|Azimilide Dihydrochloride|125 mg azimilide tablets, twice a day for 6 months
5821325|NCT00035451|Drug|Placebo|tablets, twice daily for 6 months
5821326|NCT00035451|Drug|Sotalol|160 mg sot twice daily for 6 months
5821327|NCT00035438|Drug|St. John’s Wort|
5821328|NCT00035425|Drug|linezolid|600mg every 12 hours
5821329|NCT00035425|Drug|vancomycin|1gm every 12 hours. The dose of vancomycin intravenously may be adjusted for renal function, but the patient must be able to receive a 300 mL volume of intravenous fluid at the assigned dosing times of every 12 hours.
5821330|NCT00035412|Drug|St. John’s Wort|
5821331|NCT00035399|Procedure|Acupuncture|
5821332|NCT00035360|Drug|PEG-Intron|
5821333|NCT00035347|Drug|IV azithromycin|500 mg once daily
5821334|NCT00035347|Drug|ceftriaxone|1 gram once daily for 2 to 5 days
5821335|NCT00035347|Drug|oral azithromycin|2 x 250 mg once daily
5821336|NCT00035347|Drug|IV levofloxacin|500 mg once daily
5821337|NCT00035347|Drug|oral levofloxacin|500 mg once daily
5821338|NCT00035386|Procedure|trans-right ventricular alcohol septal ablation (TRVASA)|
5821339|NCT00035334|Drug|NC-503 (Anti-amyloidotic (AA) Agent)|
5821340|NCT00035321|Drug|Olanzapine|
5821341|NCT00035321|Drug|Fluoxetine|
5821342|NCT00035308|Drug|Abetimus sodium (LJP 394)|
5821343|NCT00035295|Drug|MK0869, aprepitant|
5821344|NCT00035295|Drug|Comparator: placebo|
5821345|NCT00035282|Drug|aprepitant|
5821346|NCT00035282|Drug|Comparator: placebo (unspecified)|
5821347|NCT00035269|Drug|Antibiotic|
5821348|NCT00035256|Drug|teriparatide|
5821349|NCT00035256|Drug|raloxifene HCl|
5821350|NCT00035256|Drug|placebo|
5821351|NCT00035243|Drug|epothilone b|EPO906 administered intravenously at 2.5 mg/m2 as a 5 minute bolus infusion repeated every week for three weeks followed by one week off The final tables and data is not in yet, so I cannot give you info on safety issues.
5821352|NCT00035230|Drug|Topiramate|
5821353|NCT00035204|Drug|galantamine|
5821354|NCT00035191|Drug|galantamine|
5821355|NCT00035178|Drug|Argatroban|
5821356|NCT00035165|Drug|epothilone b|intravenous 2.5 mg/m2 as a 5 minutes bolus infusion once every week for three weeks followed by one week off
5821357|NCT00035152|Drug|Paclitaxel and carboplatin|
5821358|NCT00035139|Drug|methylphenidate|
5821359|NCT00035126|Drug|epothilone b|
5821360|NCT00035113|Drug|epothilone b|
5821361|NCT00035100|Drug|epothilone b|
5821362|NCT00035087|Drug|epothilone b|
5821363|NCT00035074|Drug|Methotrexate|
5821364|NCT00035061|Drug|pemetrexed|
5821365|NCT00035048|Drug|aprepitant|
5821366|NCT00035048|Drug|Comparator: placebo (unspecified)|
5821367|NCT00035035|Drug|GEMZAR|
5821368|NCT00035035|Drug|ALIMTA|
5821369|NCT00035022|Drug|BCX-1777|
5821370|NCT00035009|Drug|MK0869, aprepitant|
5821371|NCT00035009|Drug|Comparator: paroxetine HCL|
5821372|NCT00034983|Drug|aprepitant|
5821373|NCT00034983|Drug|Comparator: paroxetine HCL|
5821374|NCT00034970|Behavioral|Mindfulness-based at therapy|
5821375|NCT00034957|Drug|Investigational drug|
5821376|NCT00034944|Drug|MK0869, aprepitant|
5821377|NCT00034944|Drug|Comparator: placebo|
5821378|NCT00034918|Drug|ZD6474|
5821379|NCT00034905|Drug|quetiapine fumarate vs risperidone|
5821380|NCT00034892|Drug|Olanzapine, risperidone|
5821381|NCT00034879|Drug|ZD1839 (Gefitinib)|
5821382|NCT00034866|Drug|Protease inhibitor tipranavir|
5821383|NCT00034853|Drug|meloxicam oral suspension|
5821384|NCT00034853|Drug|naproxen oral suspension|
5821385|NCT00034840|Drug|telmisartan, valsartan|
5821386|NCT00034827|Drug|CI-1040|
5821387|NCT00034814|Drug|Talampanel|Non-enzyme-inducing TLP 35mg TID
5821388|NCT00034814|Drug|Placebo|Enzyme-inducing placebo TID
5821389|NCT00034814|Drug|Talampanel|Enzyme-inducing Talampanel 35 mg TID
5821390|NCT00034814|Drug|Talampanel|Enzyme-inducing TLP 50mg TID
5821391|NCT00034814|Drug|Placebo|Non-enzyme-inducing placebo TID
5821392|NCT00034814|Drug|Talampanel|Non-enzyme-inducing TLP 25mg TID
5821393|NCT00034801|Drug|olanzapine|
5821394|NCT00034801|Drug|ziprasidone|
5821395|NCT00034788|Drug|Becaplermin|
5821396|NCT00034775|Drug|risperidone|
5821397|NCT00034762|Drug|risperidone|
5821398|NCT00034749|Drug|Risperidone|
5821399|NCT00034736|Drug|Levofloxacin|
5821400|NCT00034710|Drug|Capsaicin Patch|
5821401|NCT00034697|Drug|temozolomide|
5821402|NCT00034684|Drug|Farnesyl Protein Transferase Inhibitor|
5821403|NCT00034671|Drug|Posaconazole oral suspension|
5821404|NCT00034658|Drug|Posaconazole|
5821405|NCT00034645|Drug|Posaconazole oral suspension|
5821406|NCT00034632|Drug|Posaconazole oral suspension|
5821407|NCT00034619|Drug|ALIMTA|
5821408|NCT00034619|Drug|Oxaliplatin|
5821409|NCT00034606|Drug|Pemetrexed (Alimta) in combination with gemcitabine (Gemzar)|
5821410|NCT00034593|Drug|ALIMTA|
5821411|NCT00034593|Drug|gemcitabine|
5821412|NCT00034580|Drug|olanzapine|
5821413|NCT00034580|Drug|risperidone|
5821508|NCT00033020|Behavioral|Behavior Therapy|
5821509|NCT00033007|Behavioral|Behavior Therapy|
5821510|NCT00032994|Behavioral|Behavior Therapy|
5821414|NCT00034554|Biological|gp75 DNA vaccine|6 patients will be enrolled in each of the 5 vaccination groups. Patients in vaccination groups 1-3 will receive a total of 5(1 mL) vaccinations. Patients assigned to vaccination group 4 will receive a total of 5 (2.0 mL) vaccinations administered as 2 1 mL injections. Patients assigned to vaccination group 5 will receive a total of 5 (4.0 mL or 8.0 mg)vaccinations administered as 4 1 mL injections per vaccination treatment Patients will receive gp75 DNA vaccinations every 3 weeks for 5 vaccinations. Injection sites will be given intramuscularly and rotated for each dose using all 4 limbs with the exception of a site that had the removal of lymph nodes. Progression to next higher dose level will be based on the 5* patient safely completing the 2nd vaccination at the lower dose level.
5821415|NCT00034541|Biological|cetuximab|400 mg/m2 i.v. over 120 minutes
5821416|NCT00034541|Drug|paclitaxel|225 mg/m2, infusion
5821417|NCT00034541|Drug|carboplatin|30-minute AUC = 6, infusion.
5821418|NCT00034528|Drug|Busulfan|0.8 mg/kg/d administered as a single intravenous infusion over 3 hours for 4 days. All infusions are anticipated to be given in the outpatient clinic.
5821419|NCT00034528|Drug|Fludarabine|30 mg/m^2/d administered as a bolus infusion over 30 minutes for 4 days. All infusions are anticipated to be given in the outpatient clinic.
5821420|NCT00034528|Drug|FK506|0.15 mg/kg taken orally daily for 12 to 14 weeks
5821421|NCT00034528|Drug|Prednisone|0.5 mg/kg taken orally four times daily on Day 7 and increase to 1 mg/kg taken orally four times daily on Day 14. Participants will continue regimen until Day 30 before a 20-25% taper per week.
5821422|NCT00034515|Drug|denufosol tetrasodium (INS37217) Inhalation Solution|
5821423|NCT00034502|Drug|ALIMTA|
5821424|NCT00034502|Drug|irinotecan|
5821425|NCT00034489|Drug|pemetrexed|
5821426|NCT00034489|Drug|gemcitabine|
5821427|NCT00034476|Drug|sPLA2 Inhibitor|
5821428|NCT00034463|Drug|ALIMTA|
5821429|NCT00034463|Drug|folic acid|
5821430|NCT00034463|Drug|multi-vitamins|
5821431|NCT00034450|Drug|L-carnitine|
5821432|NCT00034385|Drug|Valganciclovir|
5821433|NCT00034372|Drug|oregovomab|
5821434|NCT00034359|Drug|ACH-126, 443 (beta-L-Fd4C)|
5821435|NCT00034359|Drug|Lamivudine|
5821436|NCT00034359|Drug|Placebo|
5821437|NCT00017862|Drug|SCH55700|
5821438|NCT00034346|Drug|ABX-EGF|
5821439|NCT00034346|Drug|paclitaxel|
5821440|NCT00034346|Drug|carboplatin|
5821441|NCT00034333|Drug|MTC-DOX for Injection|
5821442|NCT00034307|Drug|sitaxsentan sodium|
5821443|NCT00034294|Drug|GT160-246|
5821444|NCT00034281|Drug|TAK-165|Starting dose of TAK-165 10 mg, tablets, orally, once daily with dose escalation to tolerability for 56 days.
5821445|NCT00034268|Drug|LY900003|
5821446|NCT00034255|Drug|INGAP Peptide|
5821447|NCT00034203|Drug|efalizumab|
5821448|NCT00034190|Drug|S-8184 Paclitaxel Injectable Emulsion|
5821449|NCT00034177|Drug|S-8184 Paclitaxel Injectable Emulsion|
5821450|NCT00034177|Drug|Experimental Arm: TOCOSOL Paclitaxel|Doses of 80, 100 and 120mg/m2
5821451|NCT00034242|Drug|high-dose intravenous immunoglobulin (IVIG)|
5821452|NCT00034229|Drug|Felbamate|
5821453|NCT00034164|Drug|S-8184 Paclitaxel Injectable Emulsion|
5821454|NCT00034151|Drug|S-8184 Paclitaxel Injectable Emulsion|
5821455|NCT00034138|Drug|oregovomab|
5821456|NCT00034125|Drug|LY353381|
5821457|NCT00034125|Drug|tamoxifen|
5821458|NCT00034112|Procedure|osteopathic manipulative treatment|
5821459|NCT00034086|Drug|Lopinavir/Ritonavir|
5821460|NCT00034086|Drug|Lamivudine/Zidovudine|
5821461|NCT00034086|Drug|Tenofovir disoproxil fumarate|
5821462|NCT00034086|Biological|Pneumococcal Vaccine, Polyvalent (23-valent)|
5821463|NCT00034086|Drug|Lamivudine|
5821464|NCT00034086|Drug|Stavudine|
5821465|NCT00034086|Drug|Zidovudine|
5821466|NCT00034086|Drug|Didanosine|
5821467|NCT00034086|Biological|Lyme Disease Vaccine Recombinant OspA|
5821468|NCT00034086|Biological|Haemophilus B Conjugate Vaccine|
5821469|NCT00034060|Drug|Etanercept|
5821470|NCT00034047|Procedure|Acupuncture|
5821471|NCT00034047|Drug|Chinese Products|
5821472|NCT00034047|Drug|Nafarelin|
5821473|NCT00034034|Procedure|Acupuncture|
5821474|NCT00034021|Drug|Ginkgo Biloba|
5821475|NCT00034021|Behavioral|Sex Therapy (genital focus)|
5821476|NCT00034008|Behavioral|Healing Touch|
5821477|NCT00033982|Drug|Posaconazole|
5821478|NCT00033956|Drug|M40403|
5821479|NCT00033943|Drug|deligoparin|
5821480|NCT00033917|Drug|indomethacin|an anti-inflammatory drug
5821481|NCT00033917|Drug|placebo|saline
5821482|NCT00033904|Drug|autologous human tumor-derived HSPPC-96|
5821483|NCT00033891|Drug|Infliximab|
5821484|NCT00033878|Drug|Noni Extract|
5821485|NCT00033865|Behavioral|Yoga, Relaxation Exercises, Sleep Hygiene|Sleep hygiene and relaxation exercises, with additional yoga
5821486|NCT00033852|Procedure|Massage Therapy|
5821487|NCT00033839|Drug|Civamide (Zucapsaicin)|
5821488|NCT00033813|Drug|Oxatomide (tinset)|
5821489|NCT00033215|Drug|S-3304|
5821490|NCT00033202|Drug|Gimatecan® (ST-1481)|
5821491|NCT00033189|Drug|Coenzyme Q10|
5821492|NCT00033176|Drug|Alpha Lipoic Acid|
5821493|NCT00033163|Drug|Adefovir dipivoxil|
5821494|NCT00033163|Drug|Tenofovir disoproxil fumarate|
5821495|NCT00033150|Behavioral|Fast ForWord|
5821496|NCT00033150|Behavioral|Computer Assisted Language Intervention|
5821497|NCT00033150|Behavioral|Individual Language Intervention|
5821498|NCT00033150|Behavioral|Academic enrichment|
5821499|NCT00033124|Behavioral|Behavior Therapy|
5821500|NCT00033111|Drug|Cabergoline|
5821501|NCT00033111|Drug|Placebo|sugar pill manufactured to mimic cabergoline 05mg tablet
5821502|NCT00033098|Drug|Metyrapone|
5821503|NCT00033085|Drug|Ondansetron|
5821511|NCT00032981|Behavioral|Behavior Therapy|
5821512|NCT00032968|Drug|Buprenorphine/naloxone|
5821513|NCT00032955|Drug|Buprenorphine/naloxone|
5821514|NCT00032942|Drug|Lofexidine|
5821515|NCT00032929|Drug|Selegiline|
5821516|NCT00032916|Drug|NS2359|
5821517|NCT00032903|Drug|Gimatecan® (ST 1481)|
5821518|NCT00032890|Drug|glucosamine|
5821519|NCT00032890|Drug|chondroitin sulfate|
5821520|NCT00032890|Drug|glucosamine and chondroitin sulfate combined|
5821521|NCT00032890|Drug|celecoxib|
5821522|NCT00032838|Drug|Yohimbine|
5821523|NCT00032825|Drug|Ketaconazole|
5821524|NCT00032825|Drug|Docetaxel|
5821525|NCT00032799|Drug|natalizumab|
5821526|NCT00032786|Drug|natalizumab|
5821527|NCT00032773|Drug|pentostatin for injection|
5821528|NCT00032812|Drug|Raclopride|
5821529|NCT00032760|Behavioral|Meditation|
5821530|NCT00032747|Drug|Vasopressin V2 Receptor Antagonist|
5821531|NCT00032734|Drug|satavaptan (SR121463B)|
5821532|NCT00032721|Procedure|Reiki; Subtle energy therapy|
5821533|NCT00032708|Biological|Dryvax|
5821534|NCT00032695|Drug|methionine|
5821535|NCT00032669|Drug|HAART|
5821536|NCT00032643|Drug|DITPA|
5821537|NCT00032630|Procedure|Coronary artery bypass - on-pump|CABG procedure performed on heart lung machine
5821538|NCT00032630|Procedure|Coronary artery bypass - off-pump|CABG procedure performed without the use of the heart lung machine
5821539|NCT00032617|Procedure|Prolonged Exposure|trauma-focused exposure therapy
5821540|NCT00032617|Procedure|Present Centered Therapy|therapy that focuses on current problems
5821541|NCT00032591|Procedure|Weekly patient self-testing of prothrombin time|
5821542|NCT00032591|Other|High quality anticoagulation management (HQACM) with conventional monthly testing|HQACM with testing every 4 weeks and as indicated for out of range values, medication/clinical changes.
5821543|NCT00032526|Drug|Corticosteroids|
5821544|NCT00032526|Behavioral|Classical conditioning to corticosteroid|
5821545|NCT00032500|Drug|Echinacea|
5821546|NCT00032487|Drug|Insulin|Insulin (intermediate or long-lasting) in a.m. 1 unit 9 lbs Arm 1 Insulin (intermediate or long-lasting) in a.m. 1 unit 9 lbs, add one injection of insulin Arm 2
5821547|NCT00032487|Drug|Glimepiride|Glimepiride 2 mg Arm 1 Glimepiride 8 mg Arm 2
5821548|NCT00032487|Drug|Rosiglitazone|Rosiglitazone 4 mg Arm 1 Rosiglitazone 4 mg bid Arm 2
5821549|NCT00032487|Drug|Metformin|Metformin 500 mg (go up to 1000 mg) Arm 1 Metformin 500 mg (go up to 2000 mg) Arm
5821550|NCT00032474|Drug|Ginkgo biloba extract|
5821551|NCT00032448|Procedure|Standardized tension-free herniorrhaphy with prosthesis|Compare the effect of two typs of operative treatment of inguinal hernia.
5821552|NCT00032435|Drug|PAL-40 Active|
5821553|NCT00032435|Drug|PAL-40 Placebo|
5821554|NCT00032422|Procedure|Acupuncture|
5821555|NCT00032409|Behavioral|Music therapy-based relaxation/stress reduction|
5821556|NCT00032396|Drug|Retisert Implant|
5821557|NCT00032383|Behavioral|Tai Chi|
5821558|NCT00032370|Procedure|Vascular surgery with best medical treatment|Patients undergo scheduled vascular surgery
5821559|NCT00032370|Procedure|Coronary artery bypass grafting (CABG)|Coronary artery bypass grafting prior to vascular surgery
5821560|NCT00032370|Procedure|Percutaneous transluminal coronary angioplasty (PTCA)|Cardiac revascularization via PTCA prior to vascular surgery
5821561|NCT00032357|Procedure|Ferritin reduction to 25 ng/ml by phlebotomy|
5821562|NCT00032344|Procedure|Colonoscopy|Phase I - Cross-sectional; Phase II - 5 year follow-up; Phase III - 10 year follow-up
5821563|NCT00032331|Procedure|PET Imaging|
5821564|NCT00032331|Procedure|CT scan|
5821565|NCT00032305|Drug|Visilizumab|
5821566|NCT00032292|Drug|Visilizumab|
5821567|NCT00032279|Drug|Visilizumab|
5821568|NCT00032240|Device|Shoe Insert|
5821569|NCT00032227|Procedure|Early Carpal Tunnel Release for Mild or Moderate CTS|Either open or endoscopic surgery
5821570|NCT00032227|Other|MR Nerve Imaging for CTS|New diagnostic test for CTS to directly image the median nerve
5821571|NCT00031551|Drug|Etanercept|
5821572|NCT00031551|Drug|Placebo|
5821573|NCT00031512|Drug|Placebo|Placebo.
5821574|NCT00031512|Drug|Pleconaril (VP63843)|5 mg/kg /dose oral every 8 hours for 7 days (21 doses) of a 40 mg/mL oral liquid formulation and 8.5 mg/kg/dose oral every 8 hours for 7 days (21 doses) of a 40 mg/mL oral suspension formulation.
5821575|NCT00031499|Drug|Azithromycin|Single 2 gram oral dose (4 tablets) at Day 1.
5821576|NCT00031499|Drug|Benzathine Penicillin|Supplied in pre-filled syringes containing 1.2 million units of benzathine penicillin; 2.4 million units administered intramuscularly at Day 1, in one or both buttocks.
5821577|NCT00031499|Drug|Doxycycline|Baseline visit, 28 capsules dispensed, for a dose of 100 mg twice a day (BID).
5821578|NCT00031486|Drug|Valacyclovir|Valacyclovir is a L-valyl ester of acyclovir. Valacyclovir is provided in 500 mg tablets, 4 tablets (500 mg tablets) 3 times a day (every 8 hours) for 90 days.
5821579|NCT00031486|Drug|Placebo|Placebo (identical to active drug in appearance) 500 mg tablets, 4 tablets 3 times daily for 90 days.
5821580|NCT00031473|Drug|Virazole (Ribavirin) Inhalation Solution|
5821581|NCT00031460|Drug|Acyclovir|Oral banana flavored acyclovir suspension: 300 mg/m^2/dose three times a day (TID), to be given at least 6 to 8 hours apart for 6 months. Dosage adjustments will be made monthly to compensate for increases in body surface area.
5821582|NCT00031460|Drug|Placebo|Oral banana flavored placebo suspension: to be given at least 6 to 8 hours apart for 6 months. Dosage adjustments will be made monthly to compensate for increases in body surface area.
5821583|NCT00031447|Drug|Acyclovir|Oral suspension 300 mg/m^2/dose, 3 times per day (TID), for 6 months.
5821584|NCT00031447|Drug|Placebo|Placebo identical to oral acyclovir suspension in appearance and taste.
5821652|NCT00030056|Drug|GM-CSF (granulocyte-macrophage colony-stimulating factor, sargramostim)|
5821653|NCT00030043|Device|Penetrating auditory brainstem implant|
5821585|NCT00031434|Drug|Valganciclovir|Valganciclovir is a mono-valyl ester pro-drug of ganciclovir, which is rapidly converted to ganciclovir on absorption. Valganciclovir oral syrup formulation for administration will be provided as a 15g powder blend containing 3g valganciclovir base, for constitution in 120 mL amber glass bottles. The beginning oral valganciclovir dose under investigation is 14 mg/kg. The dose of oral valganciclovir syrup will be adjusted for the baby's weight and renal function. Weights upon which dosage will be adjustments will be made will be obtained on study days 1, 7, 14, 21, 28, and 35.
5821586|NCT00031434|Drug|Ganciclovir|Ganciclovir for intravenous infusion will be provided as sterile, lyophilized powder in sealed vials containing 500 mg ganciclovir for re-constitution. The dose of intravenous ganciclovir is 6 mg/kg. Intravenous ganciclovir will be adjusted for the baby's weight and renal function. Weights upon which dosage adjustments will be made will be obtained on study days 1, 7, 14, 21, 28, and 35. Each dose of intravenous ganciclovir should be given over 1 hour using an intravenous pump.
5821587|NCT00031395|Drug|clonidine|Clonidine is FDA-approved for the treatment of hypertension in adults.
5821588|NCT00031395|Drug|methylphenidate|MPH is FDA-approved for the treatment of ADHD symptoms in children.
5821589|NCT00031395|Other|placebo|an inactive substance
5821590|NCT00031343|Drug|highly active antiretroviral therapy (HAART)|
5821591|NCT00031317|Drug|Paroxetine|
5821592|NCT00031317|Drug|Clozapine|
5821593|NCT00031291|Drug|Anthrax Immune Globulin|
5821594|NCT00031278|Drug|CPG 7909|Each 0.01 mg/kg CPG 7909 treatment will consist of a monitored 2-hour infusion given once weekly until disease progression or a maximum of 24 weeks.
5821595|NCT00031278|Drug|Herceptin®|Herceptin® will be administered at a dose of 2 mg/kg IV according to the Herceptin® package insert
5821596|NCT00031278|Drug|CPG 7909|Each 0.04 mg/kg CPG 7909 treatment will consist of a monitored 2-hour infusion given once weekly until disease progression or a maximum of 24 weeks.
5821597|NCT00031278|Drug|Herceptin®|Herceptin® will be administered at a dose of 2 mg/kg IV according to the Herceptin® package insert
5821598|NCT00031278|Drug|CPG 7909|Each 0.16 mg/kg CPG 7909 treatment will consist of a monitored 2-hour infusion given once weekly until disease progression or a maximum of 24 weeks.
5821599|NCT00031278|Drug|Herceptin®|Herceptin® will be administered at a dose of 2 mg/kg IV according to the Herceptin® package insert
5821600|NCT00031278|Drug|CPG 7909|Each 0.32 mg/kg CPG 7909 treatment will consist of a monitored 2-hour infusion given once weekly until disease progression or a maximum of 24 weeks.
5821601|NCT00031278|Drug|Herceptin®|Herceptin® will be administered at a dose of 2 mg/kg IV according to the Herceptin® package insert
5821602|NCT00031265|Procedure|Family Intervention Telephone Tracking|
5821603|NCT00031187|Drug|SGN-15 (cBR96-doxorubicin immunoconjugate)|
5821604|NCT00031187|Drug|Taxotere (docetaxel)|
5821605|NCT00031161|Drug|Nitisinone (NTBC)|
5821606|NCT00031161|Drug|Dichloroacetate|
5821607|NCT00031161|Behavioral|Low-tyrosin diet|
5821608|NCT00031148|Drug|Recombinant Human Keratinocyte Growth Factor (rHuKGF)|
5821609|NCT00031135|Drug|Choline Chloride|
5821610|NCT00031122|Other|No Intervention|There is no intervention in this study
5821611|NCT00031109|Biological|gp160 MN/LAI-2|
5821612|NCT00031109|Biological|Aluminum hydroxide|
5821613|NCT00031096|Drug|Azelaic Acid Gel 15% (Finacea, BAY39-6251)|Azelaic Acid 15% gel (SH H 655 BA) applied topically two times per day.
5821614|NCT00031096|Drug|Vehicle gel (SH H 655 PBA)|Vehicle gel (SH H 655 PBA) applied topically two times per day.
5821615|NCT00031083|Genetic|Interferon-beta|
5821616|NCT00031070|Drug|Abacavir sulfate, Lamivudine and Zidovudine|
5821617|NCT00031070|Drug|Cyclosporine|
5821618|NCT00031070|Biological|Hepatitis A Vaccine (Inactivated)|
5821619|NCT00031070|Drug|Efavirenz|
5821620|NCT00031070|Biological|Pneumococcal Conjugate Vaccine, Heptavalent|
5821621|NCT00031070|Biological|Rabies Vaccine|
5821622|NCT00031057|Drug|Thiamine hydrochloride|
5821623|NCT00031057|Drug|Riboflavin|
5821624|NCT00031044|Drug|Enfuvirtide|
5821625|NCT00031044|Drug|Amdoxovir|
5821626|NCT00031031|Drug|Kanglaite Injection (KLT)|
5821627|NCT00031018|Drug|Aricept|
5821628|NCT00031018|Drug|IFN-alpha2A|
5821629|NCT00031005|Procedure|modified stem cell transplant|
5821630|NCT00030992|Drug|BMS-247550|One hour infusion on five successive days (daily x 5) every three weeks. Starting dose of 6 mg/m^2/day for a total per cycle dose of 30 mg/m^2
5821631|NCT00030992|Drug|Ranitidine|50 mg 30-60 minutes prior to Ixabepilone (BMS-247550)
5821632|NCT00030992|Drug|Diphenhydramine|50 mg intravenously 30-60 minutes prior to Ixabepilone (BMS-247550)
5821633|NCT00030979|Drug|Donepezil|
5821634|NCT00030966|Drug|Natalizumab|Natalizumab, 300 mg, monthly IV infusion for up to 116 weeks.
5821635|NCT00030966|Drug|Placebo|Placebo monthly infusion for up to 116 weeks.
5821636|NCT00030238|Drug|Calcium supplement|Calcium Carbonate capsules prepared by NIH PDS
5821637|NCT00030238|Drug|Placebo|Placebo capsules prepared by the NIH PDS to be identical to Calcium Carbonate capsules
5821638|NCT00030225|Biological|ELAD|
5821639|NCT00030225|Other|Standard of care (Control)|
5821640|NCT00030186|Drug|CEP-701 60mg|60mg orally 2 times a day for 28 days
5821641|NCT00030186|Drug|Cep-701 80mg|80mg 2 times a day, dependent upon response to cycle 1
5821642|NCT00030186|Drug|Cep-701 40mg|40mg 2 times a day, dependent upon response to cycle 1
5821643|NCT00030173|Drug|Epothilone D (KOS-862)|
5821644|NCT00030160|Behavioral|Strength Training|
5821645|NCT00030147|Drug|Raloxifene|60 mg a day orally administered
5821646|NCT00030147|Drug|Rimostil|1000 mg twice a day administered orally
5821647|NCT00030147|Drug|Transdermal Estradiol|100 microgram per day transdermal estradiol
5821648|NCT00030147|Drug|Placebo skin patch and placebo tablets|matched placebo skin patch to transdermal estradiol and matched tablets to either Raloxifene or Rimostil
5821649|NCT00030121|Drug|recombinant human atrial natriuretic polypeptide|
5821650|NCT00030069|Drug|Calcitriol|
5821651|NCT00030069|Drug|Dexamethasone|
5821838|NCT00025792|Drug|Pramipexole|
5821654|NCT00030030|Drug|Silymarin (milk thistle)|
5821655|NCT00030004|Procedure|spinal manipulation|
5821656|NCT00030004|Drug|midazolam|
5821657|NCT00029991|Drug|Gingko Biloba (Herb)|
5821658|NCT00029926|Drug|2-deoxy-2 [F-18] fluoro-2-d-glucose|
5821659|NCT00029913|Other|Observation|Observation of participants who received HIV preventive vaccine and became infected.
5821660|NCT00029900|Drug|ADI PEG|
5821661|NCT00029874|Drug|Minocycline|
5821662|NCT00029861|Drug|Rimonabant (SR141716)|
5821663|NCT00029848|Drug|Rimonabant (SR141716)|
5821664|NCT00029835|Drug|Rimonabant (SR141716)|
5821665|NCT00029822|Drug|Alfuzosin (SL770499)|
5821666|NCT00029809|Behavioral|Chinese exercise modalities|
5821667|NCT00029796|Drug|soy isoflavones|
5821668|NCT00029783|Procedure|Distant Healing|
5821669|NCT00029770|Procedure|Chiropractic spinal manipulation|
5821670|NCT00029770|Drug|Acetaminophen|
5821671|NCT00029770|Behavioral|Self-care|
5821672|NCT00029770|Drug|Non-Steroidal anti-inflammatory drugs (NSAIDS)|
5821673|NCT00029770|Drug|Tylenol with codeine|
5821674|NCT00029757|Drug|Estrogen|
5821675|NCT00029731|Drug|Arginine hydrochloride|
5821676|NCT00029692|Drug|Ginseng|
5821677|NCT00029692|Drug|Ginkgo|
5821678|NCT00029679|Drug|Gingko biloba|
5821679|NCT00029679|Drug|Borage oil|
5821680|NCT00029666|Device|Neopulse Magnetic Stimulator|
5821681|NCT00029627|Drug|Yohimbine|
5821682|NCT00029614|Drug|Atomoxetine|
5821683|NCT00029575|Device|Surgi-Vision Guidewire Coil|
5821684|NCT00029536|Biological|Progesterone Lozenges|200mg Progesterone Lozenges
5821685|NCT00029536|Other|Matched Placebo Lozenges|Matched Placebo Lozenges
5821686|NCT00029523|Drug|Intrathecal (injected into the spinal fluid) DepoCyt|
5821687|NCT00029523|Drug|Intrathecal methotrexate|
5821688|NCT00029523|Drug|Intrathecal cytarabine (also known as ara-C)|
5821689|NCT00029510|Drug|Magnesium|
5821690|NCT00029497|Procedure|Acupuncture|
5821691|NCT00029497|Drug|Amitriptyline|
5821692|NCT00029484|Behavioral|Tai chi chih|
5821693|NCT00029458|Drug|Clozapine|
5821694|NCT00029393|Procedure|Hematopoietic Stem Cell Transplantation|
5821695|NCT00029393|Drug|Immunosuppression|
5821696|NCT00029380|Drug|Sangstat|
5821697|NCT00029380|Drug|Cyclophosphamide|
5821698|NCT00029380|Drug|Busulfan|
5821699|NCT00029380|Drug|Mycophenolate Mofetil|
5821700|NCT00029380|Drug|Cyclosporine|
5821701|NCT00029380|Procedure|Cord Blood Transplantation|
5821702|NCT00029341|Behavioral|Treatment Interruption|
5821703|NCT00029328|Drug|etanercept|
5821704|NCT00029315|Drug|Recombinant Tissue Plasminogen Activator (rt-PA)|
5821705|NCT00029289|Drug|Lutein (10 or 30 mg/day) capsules|
5821706|NCT00029276|Procedure|Prefrontal transcranial magnetic brain stimulation|
5821707|NCT00029263|Drug|herbals|
5821708|NCT00029250|Drug|Garlic powder standardized to allicin|
5821709|NCT00029237|Behavioral|Cognitive-behavioral relaxation (Positively Living)|
5821710|NCT00029237|Behavioral|Spiritual growth group|
5821711|NCT00029237|Behavioral|Focused Tai Chi|
5821712|NCT00029224|Drug|zoledronic acid|
5821713|NCT00029211|Drug|Echinacea|
5821714|NCT00029198|Procedure|massage|15 massage given tid
5821715|NCT00029198|Procedure|Sham massage|non-massage touch
5821716|NCT00029185|Drug|Dehydrex|
5821717|NCT00029172|Other|case management|
5821718|NCT00029159|Drug|estrogen|Participants were started on ethinyl estradiol at a daily dose of 50ng/kg at the beginning of the 3rd year of the study. The estrogen was continued until study end.
5821719|NCT00029159|Drug|androgen|Oxandrolone or placebo capsule, .06mg/kg/day, orally, for 2 years
5821720|NCT00029159|Other|placebo|an inactive substance
5821721|NCT00029146|Procedure|extracranial-intracranial bypass surgery|Surgical anastomosis of a superficial temporal artery branch to a middle cerebral artery branch through a small craniectomy plus best current practice medical therapy
5821722|NCT00029146|Drug|best medical therapy|best current practice medical therapy
5821723|NCT00029133|Procedure|mild intraoperative hypothermia (33 degrees Celsius)|
5821724|NCT00028431|Biological|MDX-CTLA4 Antibody; Tyrosinase/gp100/MART-1 Peptides Melanoma Vaccine|
5821725|NCT00028418|Drug|Clofarabine|
5821726|NCT00028405|Drug|LS 11(Taporfin Sodium)|
5821727|NCT00028405|Device|Lumaflex Light Delivery Catheter|
5821728|NCT00029107|Drug|Rituximab|anti-CD20 monoclonal antibody
5821729|NCT00029042|Drug|Infliximab|
5821730|NCT00028379|Procedure|Transcranial magnetic stimulation (TMS)|
5821731|NCT00028366|Drug|Fosamprenavir|
5821732|NCT00028366|Drug|Lopinavir/Ritonavir|
5821733|NCT00028366|Drug|Ritonavir|
5821734|NCT00028366|Drug|Tenofovir disoproxil fumarate|
5821735|NCT00028353|Drug|GTX-006 (Acapodene)|
5821736|NCT00028327|Drug|Lamivudine/Zidovudine|
5821737|NCT00028327|Drug|Nelfinavir mesylate|
5821738|NCT00028327|Drug|Efavirenz|
5821739|NCT00028327|Drug|Lamivudine|
5821740|NCT00028327|Drug|Zidovudine|
5821741|NCT00028314|Drug|Abacavir sulfate|
5821742|NCT00028314|Drug|Atazanavir/Ritonavir|
5821743|NCT00028314|Drug|Lopinavir/Ritonavir|
5821744|NCT00028314|Drug|Nevirapine|
5821745|NCT00028301|Drug|Atazanavir|
5821746|NCT00028301|Drug|Lopinavir/Ritonavir|
5821747|NCT00028288|Drug|Daclizumab|
5821748|NCT00028275|Drug|Gamma Interferon 1b|
5821749|NCT00028262|Drug|Cystagon|
5821750|NCT00028236|Drug|Gene-Transduced Autologous CD34+ Stem Cells|
5821751|NCT00028171|Drug|Tacrolimus|
5821752|NCT00028158|Drug|G207, an oncolytic virus|
5821839|NCT00025779|Drug|methylphenidate|
5821840|NCT00025779|Drug|guanfacine|
5821753|NCT00028145|Behavioral|Adherence assessment|Adherence will be assessed using questionnaires at all study visits.
5821754|NCT00028132|Drug|Tenofovir|
5821755|NCT00028106|Drug|[131]I-MIBG|
5821756|NCT00028106|Drug|6-[18F]Fluorodopamine|
5821757|NCT00028106|Drug|[123]I-MIBG|
5821758|NCT00028093|Drug|Peginterferon alfa-2a with Ribavirin|Eligible patients were given peginterferon alpha-2a, 180 ug subcutaneous once weekly and weight-based oral ribavirin (1000 mg daily for patients <75 kg and 1200 mg daily for patients >=75 kg) for 48 weeks
5821759|NCT00028093|Drug|Peginterferon alfa-2a|Eligible patients were given peginterferon-alpha-2a, 180 ug subcutaneous once weekly for the first 4 weeks of therapy, after which peginterferon was continued at the same dose and weight-based oral ribavirin was added and continued for an additional 44 weeks.
5821760|NCT00028067|Drug|Atazanavir|
5821761|NCT00028067|Drug|Nelfinavir mesylate|
5821762|NCT00027469|Procedure|MRI|
5821763|NCT00027456|Drug|Leptin A-100|
5821764|NCT00027443|Drug|Muromonab-CD3|
5821765|NCT00027443|Drug|Cyclosporine|
5821766|NCT00027430|Drug|TheraDerm|
5821767|NCT00027417|Drug|Liothyronine sodium/triiodothyronine|
5821768|NCT00027417|Procedure|Cardiopulmonary bypass and cardiac surgery|
5821769|NCT00027404|Drug|Fluoxetine|
5821770|NCT00027391|Drug|Albuterol|
5821771|NCT00027391|Drug|Oxandrolone|
5821772|NCT00027378|Drug|fluoxetine (Prozac)|fluoxetine plus Treatment As Usual (TAU); 12 weeks acute phase; plus 9 month naturalistic follow up
5821773|NCT00027378|Drug|Placebo plus Treatment As Usual|placebo plus Treatment as Usual; 12 weeks acute phase; plus 9 month naturalistic follow up
5821774|NCT00027365|Biological|Combination Vaccine (NefTat and gp120W61D) Formulated with AS02A|
5821775|NCT00027365|Biological|NefTat|
5821776|NCT00027365|Drug|AS02A Adjuvant|
5821777|NCT00027365|Biological|gp120W61D|
5821778|NCT00027339|Drug|lopinavir/ritonavir|
5821779|NCT00027339|Drug|indinavir sulfate|
5821780|NCT00027339|Drug|tenofovir disoproxil fumarate|
5821781|NCT00027339|Drug|ritonavir|
5821782|NCT00027339|Drug|fosamprenavir|
5821783|NCT00027300|Drug|Natalizumab|Natalizumab 300 mg IV infusion, every 4 weeks, for up to 116 weeks.
5821784|NCT00027300|Drug|Placebo|Placebo, IV infusion, every 4 weeks, for up to 116 weeks.
5821785|NCT00027287|Drug|Vitamin E|
5821786|NCT00027261|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5821787|NCT00027248|Drug|MBI 226|
5821788|NCT00027209|Drug|prempro|
5821789|NCT00027170|Device|Siemens MRI scanner|Investigational or research MRI coils may be used in the protocol. The coils are noninvasive devices external to the body. The coils act as antennae to receive small radiofrequency signals out of the body. Coils of the type we use are used daily in clinical MRI practice.
5821790|NCT00027144|Biological|Heat Shock Protein 70 HSP70|
5821791|NCT00027131|Biological|Heat Shock Protein 70-peptide complexes (HSP70)|
5821792|NCT00027079|Drug|ondansetron (Zofran)|
5821793|NCT00027079|Drug|naltrexone (ReVia)|
5821794|NCT00027079|Behavioral|Cognitive Behavioral Therapy|
5821795|NCT00027066|Drug|Active Aspirin|325mg tablet daily
5821796|NCT00027066|Drug|Active Warfarin|2mg scored tablet daily
5821797|NCT00027066|Drug|Aspirin placebo|325mg aspirin placebo pill
5821798|NCT00027066|Drug|Warfarin placebo|2mg scored placebo tablet
5821799|NCT00027053|Drug|Trazodone|50 to 150 mg qhs
5821800|NCT00027053|Drug|Placebo|
5821801|NCT00027040|Drug|Selegiline hydrochloride|
5821802|NCT00027027|Drug|rhuMAb 2C4|
5821803|NCT00027014|Drug|St. John's Wort|
5821804|NCT00027014|Drug|oxycodone|
5821805|NCT00027014|Drug|fentanyl|
5821806|NCT00027001|Behavioral|Aerobic and Resistance Exercises|
5821807|NCT00027001|Behavioral|Qigong|
5821808|NCT00026988|Drug|Creatine|
5821809|NCT00026975|Procedure|Hyperbaric Oxygen|
5821810|NCT00026962|Procedure|measuring estradiol and progesterone levels in saliva|
5821811|NCT00026936|Procedure|Radiotherapy|
5821812|NCT00026923|Procedure|Laparoscopic surgery|
5821813|NCT00026897|Procedure|Gamma-camera imaging|
5821814|NCT00026897|Procedure|Low-risk biopsy|
5821815|NCT00026871|Procedure|Radiotherapy|
5821816|NCT00026858|Behavioral|collaboration|
5821817|NCT00026819|Drug|Rofecoxib|
5821818|NCT00026637|Drug|sertraline|Sertraline: 25-200mg PO (orally); Subjects begin at 25mg for week 1 and increase to 50mg at the beginning of week 2. Sertraline is increased in 50mg increments when subjects score in the depressed range on the CES-D, a questionnaire that is administered every 2 weeks over the 16 week intervention period. Subjects may reduce dosage if toxicity occurs.
5821819|NCT00026637|Behavioral|cognitive behavior therapy|CBT (Cognitive Behavior Therapy) - CBT is a psychotherapy based on modifying cognitions, assumptions, beliefs and behaviors, with the aim of influencing disturbed emotions. Subjects will meet with a trained CBT therapist for 1 hour each week over the 16 week intervention period and will be given assignments to work on each week.
5821820|NCT00026624|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5821821|NCT00026624|Drug|Keyhole-Limpet Hemocyanin|
5821822|NCT00026611|Biological|Dryvax vaccine|
5821823|NCT00026585|Drug|Tamoxifen|
5821824|NCT00026559|Device|Shock Device|Shock Device
5821825|NCT00026559|Device|Auditory Startle Device|Auditory Startle Device
5821826|NCT00026065|Behavioral|Biofeedback|
5821827|NCT00026052|Drug|riluzole|
5821828|NCT00026039|Drug|estrogen|
5821829|NCT00026013|Drug|hypericum perforatum|
5821830|NCT00025987|Device|Head and Neck Cooling System|
5821831|NCT00025987|Device|Thermometer Pill|
5821832|NCT00025909|Procedure|Leukapheresis|
5821833|NCT00025896|Drug|recombinant human acid alpha-glucosidase (rhGAA)|
5821834|NCT00027222|Procedure|retinal ablation|
5821835|NCT00025818|Drug|Ophthalmic Emulsion|
5821836|NCT00025883|Drug|Metreleptin|Drug treatment
5821837|NCT00025805|Drug|G-CSF|
5821841|NCT00025766|Device|PCI with stenting|PCI with stenting of the occluded culprit infarct-related artery
5821842|NCT00025766|Behavioral|Optimal Medical Therapy|Participants will receive optimal medical therapy.
5821843|NCT00025753|Drug|rosiglitazone (Avandia)|
5821844|NCT00025753|Behavioral|Aerobic and weight lifting exercise training|
5821845|NCT00025740|Drug|clonazepam and paroxetine|
5821846|NCT00025727|Drug|Lopinavir/Ritonavir|
5821847|NCT00025727|Drug|Ritonavir|
5821848|NCT00025727|Drug|GW433908|
5821849|NCT00024986|Drug|Tenofovir DF|
5821850|NCT00024934|Drug|B-Lymphocyte Stimulator (BLyS)|
5821851|NCT00024687|Drug|SS1(dsFv)-PE38 (SS1P) Anti-Mesothelin Immunotoxin|
5821852|NCT00024674|Drug|SS1(dsFv)-PE38|
5821853|NCT00024661|Drug|LErafAON|
5821854|NCT00024648|Drug|LErafAON|
5821855|NCT00024570|Drug|IL13-PE38QQR|
5821856|NCT00024570|Procedure|targeted fusion protein therapy|
5821857|NCT00024570|Procedure|surgery|
5821858|NCT00024557|Drug|IL13-PE38QQR|
5821859|NCT00024557|Procedure|targeted fusion protein therapy|
5821860|NCT00024557|Procedure|surgery|
5821861|NCT00024544|Drug|anti-IL-4 monoclonal antibody (pascolizumab)|
5821862|NCT00024531|Drug|Atorvastatin calcium|
5821863|NCT00024518|Drug|30,000 units hrINF-alpha|
5821864|NCT00024518|Drug|5,000 hrINF-alpha|
5821865|NCT00024518|Other|Placebo|placebo was prepared as saline alone with 6mg human serum albumin (HSA).
5821866|NCT00024492|Drug|Liposome Encapsulated Mitoxantrone (LEM)|
5821867|NCT00023595|Procedure|CABG surgery plus MED|CABG plus standard medication management for Coronary Artery Disease
5821868|NCT00023595|Drug|Active Medication Alone|Standard medication for coronary artery disease and heart failure management.
5821869|NCT00023595|Procedure|CABG plus MED and SVR|H02: the experimental arm receives active medical therapy and CABG and surgical ventricular restoration whereas the control group receives active medical therapy and CABG; for H01: the experimental arm receives active medical therapy and CABG whereas the control group receives active medical therapy alone
5821870|NCT00023504|Biological|Pneumovax|To determine the function of T and B cells in vivo using immunizations in patients with known or suspected immune disorders.
5821871|NCT00023504|Biological|Rabavert|To determine the function of T and B cells in vivo using immunizations in patients with known or suspected immune disorders.
5821872|NCT00023504|Biological|Prevnar|To determine the function of T and B cells in vivo using immunizations in patients with known or suspected immune disorders.
5821873|NCT00023504|Biological|Tetanus diphtheria toxoid|To determine the function of T and B cells in vivo using immunizations in patients with known or suspected immune disorders.
5821874|NCT00023465|Procedure|FDG-PET|
5821875|NCT00023465|Procedure|spirometry|
5821876|NCT00023465|Procedure|bronchoscopy with BAL|
5821877|NCT00023452|Drug|RPT + INH once weekly for 3 months given by DOT|"Rifapentine (RPT) 900 mg once-weekly x 12 doses (3 months) for persons > 50.0 kg. For persons < 50.0 kg, the following doses will be given (Weight/Dose): 10.0-14.0 kg / 300 mg; 14.1-25.0 kg / 450 mg; 25.1-32.0 kg / 600 mg; 32.1-50.0 kg / 750 mg.~PLUS~Isoniazid (INH) 15 mg/kg (rounded up to nearest 50 or 100 mg; 900 mg max) once weekly x 12 doses if > 12 years old. INH 25 mg/kg (round up to nearest 50 or 100 mg; 900 mg max) if 2—11 years old.~Therapy will be given by Directly Observed Therapy (DOT)."
5821878|NCT00023452|Drug|Isoniazid (INH) daily for 9 months|Isoniazid (INH) 5 mg/kg (rounded up to nearest 50 or 100 mg; 300 mg max) daily x 270 doses (9 months) For children age 2 - 11, INH 10-15 mg/kg (round up to nearest 50 or 100 mg; 300 mg max) will be given.
5821879|NCT00023439|Other|Nucleic Acid Amplification Methods for diagnosis|no intervention
5821880|NCT00023426|Drug|rifapentine|
5821881|NCT00023413|Drug|Rifabutin|
5821882|NCT00023413|Drug|Efavirenz|
5821883|NCT00023400|Drug|Nelfinavir|
5821884|NCT00023400|Drug|Rifabutin|
5821885|NCT00023387|Drug|Rifapentine|
5821886|NCT00023387|Drug|25-desacetyl Rifapentine|
5821887|NCT00023387|Drug|Isoniazid|
5821888|NCT00023374|Drug|Rifampin|6mos REZ intermittent
5821889|NCT00023374|Drug|Pyrazinamide|6mos REZ intermittent
5821890|NCT00023374|Drug|Ethambutol|6mos REZ intermittent
5821891|NCT00023374|Drug|REZ|Rif+PZA+EMB given 2 or 3 times weekly for 6 months
5821892|NCT00023361|Drug|Rifabutin|
5821893|NCT00023348|Drug|Isoniazid|
5821894|NCT00023348|Drug|Rifabutin|
5821895|NCT00023335|Drug|Rifapentine|
5821896|NCT00023335|Drug|Isoniazid|
5821897|NCT00023543|Behavioral|Diet, fat-restricted|Reduction in total, saturated, trans fat, cholesterol, calories. Increase in fiber. Promotion of nutrient-dense, high-volume, low calorie foods.
5821898|NCT00023543|Behavioral|Exercise|Rigorous, stepped care approach to reach 150 min/week of physical activity.
5821899|NCT00023530|Drug|fluconazole|
5821900|NCT00023530|Drug|voriconazole|
5821901|NCT00023530|Procedure|bone marrow transplant|
5821902|NCT00023530|Drug|thalidomide|
5821903|NCT00023530|Drug|dexamethasone|
5821904|NCT00023322|Drug|Peginterferon Alpha-2a|Treatment
5821905|NCT00023309|Drug|Lamivudine and adefovir|Lamivudine (100 mg/day) and adefovir (10 mg/day)
5821906|NCT00023309|Drug|Adefovir alone|Adefovir (10 mg/day)
5821907|NCT00023296|Drug|Nitric Oxide|
5821908|NCT00023296|Device|INO Pulse - NO Delivery System|
5821909|NCT00023283|Drug|Buprenorphine|"Experimental Standard Medical Management with once-weekly medication dispensing~Experimental Standard Medical Management with thrice-weekly medication dispensing~Experimental Enhanced Medical Management with thrice-weekly medication dispensing"
5821910|NCT00023244|Drug|Basiliximab|Administered as a bolus intravenous injection. The first dose is given pre-operatively, the second dose is given on post-transplant day four. Dosage is determined by individual weight.
5821984|NCT00014911|Procedure|Islet Transplantation|Participants will receive portal vein islet infusions (up to 3), e.g., islet transplantations, with a targeted total of exceeding 10,000 islet equivalents per kilogram of body weight (IE/kg) per infusion. Up to three transplants are possible depending on individual results.
5821911|NCT00023244|Drug|Cyclosporine|Participants receiving cyclosporine microemulsion formula (in lieu of tacrolimus) will have the dose adjusted to maintain a whole blood trough Abbott TDx assay monoclonal level of 175-400 ng/mL (or an equivalent high pressure liquid chromatography (HPLC) level) for the first 2 weeks after transplant. The dose will subsequently be tapered to maintain a trough level of 175-300 ng/mL from week 3 to month 3, and 50-250 ng/mL from month 3 through the end of the study at month 36 (year 3).
5821912|NCT00023244|Drug|Tacrolimus|Participants receiving tacrolimus (in lieu of Cyclosporine) will have the dose adjusted to maintain a whole blood trough level between 10 and 15 ng/mL for the first 4weeks after transplant. Trough levels will be maintained between 5 and 10 ng/mL thereafter throughout the duration of the study.
5821913|NCT00023244|Drug|Sirolimus|Participants take daily (orally, either as tablets or as liquid) starting on postoperative day 1 at a dose of 6 mg/m2 and will be adjusted to maintain a trough level of 10-20 ng/mL throughout the study.
5821914|NCT00023244|Drug|Methylprednisolone|Administered at 10 mg/kg intravenously perioperatively and on postoperative day 1.
5821915|NCT00023244|Drug|Prednisone|Administered orally beginning on Post-Op Day 2 and maintained for all participants until day 180. Randomization will determine whether patients will maintain this treatment following day 180.
5821916|NCT00023244|Drug|Bactrim|All subjects will receive TMP SMX (Bactrim), pneumocystis jiroveci (carinii) prophylaxis, beginning on postoperative day 1 and continuing for 6 months following transplant. Dosage: 10 mg/kg taken orally three times weekly (maximum dose 160 mg).
5821917|NCT00023231|Drug|Daclizumab|1 mg/kg/dose at study entry and Weeks 2, 4, 6, and 8
5821918|NCT00023231|Drug|Methylprednisolone/prednisone|Dosage is dependent on weight and varies throughout study. Refer to protocol for more information.
5821919|NCT00023231|Drug|Mycophenolate mofetil|Solution or oral tablet taken daily. Dosage depends on body surface area.
5821920|NCT00023231|Drug|Sirolimus|Oral tablet taken once prior to transplant. Dosage dependent on body surface area.
5821921|NCT00023231|Drug|Bactrim|Oral tablet taken three times per week. Dosage is dependent on weight.
5821922|NCT00023231|Drug|Ganciclovir|Oral tablet taken daily. Dosage is dependent on weight.
5821923|NCT00023231|Drug|Lipitor|Oral tablet taken daily
5821924|NCT00023218|Drug|Lopinavir/Ritonavir|
5821925|NCT00023218|Drug|Efavirenz|
5821926|NCT00023205|Behavioral|11th grade reading level arthritis materials|
5821927|NCT00023205|Behavioral|Interactive in-person arthritis education|
5821928|NCT00022763|Drug|Enfuvirtide|
5821929|NCT00021762|Biological|HIV-1 Immunogen|
5821930|NCT00021762|Procedure|Structured Treatment Interruption|
5821931|NCT00021671|Drug|Erythromycin|
5821932|NCT00021671|Drug|Nevirapine|
5821933|NCT00021671|Drug|Ampicillin sodium|
5821934|NCT00021671|Drug|Metronidazole|
5821935|NCT00021554|Drug|Enfuvirtide|
5821936|NCT00021489|Drug|Abacavir sulfate|
5821937|NCT00021489|Drug|Mycophenolate mofetil|
5821938|NCT00021463|Drug|Abacavir sulfate, Lamivudine and Zidovudine|
5821939|NCT00021463|Drug|Abacavir sulfate|
5821940|NCT00021463|Drug|Efavirenz|
5821941|NCT00021463|Drug|Nevirapine|
5821942|NCT00017992|Drug|Lopinavir/Ritonavir|
5821943|NCT00017992|Drug|Emtricitabine|
5821944|NCT00017992|Drug|Stavudine|
5821945|NCT00017784|Drug|Valganciclovir|
5821946|NCT00017758|Drug|Pravastatin sodium|
5821947|NCT00017758|Drug|Simvastatin|
5821948|NCT00017758|Drug|Atorvastatin calcium|
5821949|NCT00017758|Drug|Nelfinavir mesylate|
5821950|NCT00017758|Drug|Efavirenz|
5821951|NCT00017719|Drug|Lamivudine|
5821952|NCT00017719|Drug|Lamivudine/Zidovudine|
5821953|NCT00017719|Drug|Nelfinavir mesylate|
5821954|NCT00017719|Drug|Nevirapine|
5821955|NCT00017719|Drug|Zidovudine|
5821956|NCT00017693|Biological|Recombinant human soluble IL-4 receptor|Subjects were randomized to twelve once weekly nebulizations of 0.75, 1.5, or 3.0 mg dose of recombinant human soluble IL-4 receptor (rsIL-4R)
5821957|NCT00017693|Biological|Placebo for Recombinant human soluble IL-4 receptor|Subjects were randomized to twelve once weekly nebulizations of placebo for recombinant human soluble IL-4 receptor (rsIL-4R). Identically prepared (to the recombinant human soluble IL-4 receptor) in the same volume
5821958|NCT00016718|Drug|Didanosine (ddI)|Antiretroviral Didanosine (ddI) : 240 mg/m^2 up to a maximum of 400 mg once daily
5821959|NCT00016718|Drug|Efavirenz (EFV)|Antiretroviral For Age Group 1 Efavirenz (EFV): dose adjusted for body size and for Age Groups 2 and 3 Efavirenz (EFV): up to a maximum of 600 mg once daily as a capsule ot 720 mg as an oral solution
5821960|NCT00016718|Drug|Emtricitabine (FTC)|Antiretroviral Emtricitabine (FTC): 6 mg/Kg up to a maximum of 200 mg once daily
5821961|NCT00016692|Drug|Z-100|
5821962|NCT00016601|Drug|Indinavir sulfate|
5821963|NCT00016601|Drug|Ritonavir|
5821964|NCT00016601|Drug|Nelfinavir mesylate|
5821965|NCT00016601|Drug|Efavirenz|
5821966|NCT00016601|Drug|Nevirapine|
5821967|NCT00016601|Drug|Medroxyprogesterone acetate|
5821968|NCT00016588|Drug|Tenofovir disoproxil fumarate|
5821969|NCT00016536|Drug|Naphthalene 2-sulfonate polymer|
5821970|NCT00016536|Drug|Carbopol polymer|
5821971|NCT00015704|Drug|Aldesleukin|
5821972|NCT00015691|Drug|Metformin hydrochloride|
5821973|NCT00015691|Drug|Rosiglitazone maleate|
5821974|NCT00015652|Drug|Ribavirin|
5821975|NCT00015652|Drug|Aldesleukin|
5821976|NCT00015652|Drug|Peginterferon alfa-2b|
5821977|NCT00014937|Drug|lopinavir/ritonavir|
5821978|NCT00014937|Drug|lamivudine/zidovudine|
5821979|NCT00014937|Drug|efavirenz|
5821980|NCT00014937|Drug|lamivudine|
5821981|NCT00014937|Drug|stavudine|
5821982|NCT00014937|Drug|zidovudine|
5821983|NCT00014937|Drug|didanosine|
5822071|NCT00006591|Drug|Ritonavir|
5822072|NCT00006591|Drug|Amprenavir|
5822073|NCT00006578|Drug|Ritonavir|
5822074|NCT00006578|Drug|Abacavir sulfate|
5821985|NCT00014911|Drug|Sirolimus|Administered at a dose of 0.2 mg/kg by mouth once pre-transplantation then 0.1 mg/kg daily post-transplantation. Dosing will be adjusted to achieve a trough peripheral blood level of 12-15 ng/mL x3 months after transplantation and 7-12 ng/mL for the remainder of the study.
5821986|NCT00014911|Drug|Tacrolimus|Administered at a dose of 1 mg by mouth once pre-transplantation followed by 1 mg twice daily post transplantation. Levels will be adjusted to achieve a peripheral blood trough level of 3-6 ng/mL for maintenance immunosuppression.
5821987|NCT00014911|Drug|Daclizumab|Administered at a dose of 1 mg/kg intravenously immediately pre-transplantation and 2, 4, 6, and 8 weeks post-transplantation, totaling 5 doses(over 8 weeks). Further daclizumab dosing may be necessary based on individual results and islet transplantation needs.
5821988|NCT00014911|Drug|Sulfamethoxazole|An antibacterial used to prevent opportunistic infections
5821989|NCT00014911|Drug|Ganciclovir|An antiviral used to kill viruses and stop viral replication
5821990|NCT00014911|Drug|Trimethoprim|An antibacterial used to prevent opportunistic infections
5821991|NCT00014911|Drug|Pentamidine|An antiprotozoal used to prevent disease
5821992|NCT00014014|Drug|Lamivudine/Zidovudine|
5821993|NCT00013897|Drug|Atazanavir|
5821994|NCT00013897|Drug|Lamivudine/Zidovudine|
5821995|NCT00013897|Drug|Efavirenz|
5821996|NCT00013871|Biological|Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed|
5821997|NCT00013871|Biological|Measles-Mumps-Rubella Vaccine (Live)|
5821998|NCT00013871|Biological|Pneumococcal Vaccine, Polyvalent (23-valent)|
5821999|NCT00013871|Biological|Pneumococcal Conjugate Vaccine, Heptavalent|
5822000|NCT00013871|Biological|Hepatitis B Vaccine (Recombinant)|
5822001|NCT00013663|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5822002|NCT00013663|Drug|Aldesleukin|
5822003|NCT00013585|Drug|Selegiline hydrochloride|
5822004|NCT00013572|Biological|ALVAC-HIV MN120TMG (vCP205)|
5822005|NCT00013520|Drug|Abacavir sulfate, Lamivudine and Zidovudine|
5822006|NCT00013520|Drug|Atazanavir|
5822007|NCT00013520|Drug|Lamivudine/Zidovudine|
5822008|NCT00013520|Drug|Abacavir sulfate|
5822009|NCT00013520|Drug|Efavirenz|
5822010|NCT00013520|Drug|Nevirapine|
5822011|NCT00013520|Drug|Lamivudine|
5822012|NCT00013520|Drug|Stavudine|
5822013|NCT00013520|Drug|Zidovudine|
5822014|NCT00013520|Drug|Didanosine|
5822015|NCT00012519|Drug|indinavir sulfate|
5822016|NCT00012519|Drug|ritonavir|
5822017|NCT00012467|Drug|Itraconazole|
5822018|NCT00012467|Drug|Flucytosine|
5822019|NCT00012467|Drug|Fluconazole|
5822020|NCT00012467|Drug|Amphotericin B|
5822021|NCT00012467|Drug|Interferon gamma-1b|
5822022|NCT00011895|Drug|Abacavir sulfate, Lamivudine and Zidovudine|
5822023|NCT00011895|Drug|Efavirenz|
5822024|NCT00011479|Drug|Abacavir sulfate|
5822025|NCT00011128|Behavioral|Antiretroviral Treatment Interruption|
5822026|NCT00011089|Drug|Tenofovir disoproxil fumarate|
5822027|NCT00011037|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|1 x 10^ 7 TCID50 administered intramuscularly
5822028|NCT00011037|Biological|MN rgp120/HIV-1|0.6 mg administered intramuscularly
5822029|NCT00011037|Biological|ALVAC(2)120(B,MN)GNP (vCP1452) placebo|ALVAC placebo administered intramuscularly
5822030|NCT00011037|Biological|MN rgp120/HIV-1 placebo|Alum placebo administered intramuscularly
5822031|NCT00011011|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5822032|NCT00009555|Drug|Testosterone|
5822033|NCT00009061|Drug|Ritonavir|
5822034|NCT00009061|Drug|Abacavir sulfate|
5822035|NCT00009061|Drug|Nelfinavir mesylate|
5822036|NCT00009061|Drug|Lamivudine|
5822037|NCT00009061|Drug|GW433908|
5822038|NCT00008866|Biological|Tetanus Toxoid Vaccine|
5822039|NCT00008866|Drug|Hydroxyurea|
5822040|NCT00008866|Drug|Didanosine|
5822041|NCT00008853|Biological|GBS III-TT-SSI|
5822042|NCT00008853|Biological|GBS III-TT-MPHL|
5822043|NCT00008554|Drug|Abacavir sulfate|
5822044|NCT00008554|Drug|Nelfinavir mesylate|
5822045|NCT00008554|Drug|Lamivudine|
5822046|NCT00008554|Drug|GW433908|
5822047|NCT00008528|Drug|Enfuvirtide|
5822048|NCT00008489|Drug|Didanosine|
5822049|NCT00008463|Drug|Ribavirin|
5822050|NCT00008463|Drug|Interferon alfa-2a|
5822051|NCT00008463|Drug|Peginterferon alfa-2a|
5822052|NCT00007787|Biological|Cyclosporine|
5822053|NCT00007787|Biological|Anti-human thymocyte globulin (rabbit)|Anti-human thymocyte globulin (rabbit) will be given at a dose of 1.5 mg/kg while undergoing transplantation. Second and subsequent doses of Thymoglobulin® will be administered if, at 24 hours post-anastomosis, the serum creatinine has not decreased by at least 20% from the pre-transplant level. Additional Anti-human thymocyte globulin (rabbit) will be given at a dose of 1.5mg/kg daily for a minimum of 5 days to a maximum of 7 days.
5822054|NCT00007787|Drug|Tacrolimus|
5822055|NCT00007449|Drug|DPC 083|
5822056|NCT00007436|Drug|Tenofovir disoproxil fumarate|
5822057|NCT00007423|Biological|ALVAC-HIV MN120TMG (vCP205)|
5822058|NCT00007423|Biological|ALVAC-RG Rabies Glycoprotein (vCP65)|
5822059|NCT00007332|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5822060|NCT00007332|Biological|MN rgp120/HIV-1 and GNE8 rgp120/HIV-1|
5822061|NCT00007202|Drug|Atazanavir|
5822062|NCT00007202|Drug|Stavudine|
5822063|NCT00007202|Drug|Didanosine|
5822064|NCT00006630|Drug|Vaccinia Immune Globulin (Human)|
5822065|NCT00006617|Drug|Abacavir sulfate|
5822066|NCT00006617|Drug|Amprenavir|
5822067|NCT00006617|Drug|Lamivudine|
5822068|NCT00006617|Drug|Zidovudine|
5822069|NCT00006604|Drug|ATV|Participants received varying doses of ATV, depending on their age and weight. The medication was administered as 50 mg, 100 mg, or 200 mg capsules or a powder formulation, depending on which study arm participants were in.
5822070|NCT00006604|Drug|Ritonavir|Administered as 100 mg capsules or oral solution.
5822078|NCT00006509|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5822079|NCT00006509|Biological|gp160 MN/LAI-2|
5822080|NCT00006495|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5822081|NCT00006495|Biological|HIV-1 Immunogen|
5822082|NCT00006443|Drug|Indinavir sulfate|
5822083|NCT00006443|Drug|Nelfinavir mesylate|
5822084|NCT00006443|Drug|Lamivudine|
5822085|NCT00006443|Drug|Stavudine|
5822086|NCT00006441|Drug|Lamivudine/Zidovudine|300/150 mg respectively twice daily for 104 weeks. Patients who develop intolerence to AZT may use Stavudine (d4T) at a dose of 40 mg daily.
5822087|NCT00006441|Drug|Nelfinavir mesylate|1250 mg twice daily for 104 weeks.
5822088|NCT00006441|Drug|Aldesleukin|7.5 million units twice daily. Treatment will last until conclusion of study.
5822089|NCT00006412|Drug|Pravastatin sodium|
5822090|NCT00006412|Drug|Fenofibrate|
5822091|NCT00006397|Drug|Indinavir sulfate|
5822092|NCT00006397|Drug|Ritonavir|
5822093|NCT00006397|Drug|Stavudine|
5822094|NCT00006397|Drug|Didanosine|
5822095|NCT00006396|Drug|Nevirapine|
5822096|NCT00006396|Drug|Zidovudine|
5822097|NCT00006339|Drug|Indinavir sulfate|
5822098|NCT00006339|Drug|Ritonavir|
5822099|NCT00006339|Drug|Hydroxyurea|
5822100|NCT00006339|Drug|Stavudine|
5822101|NCT00006339|Drug|Didanosine|
5822102|NCT00006327|Biological|MN rgp120/HIV-1 and A244 rgp120/HIV-1|
5822103|NCT00006326|Drug|Indinavir sulfate|
5822104|NCT00006326|Drug|Ritonavir|
5822105|NCT00006326|Drug|Delavirdine mesylate|
5822106|NCT00006325|Drug|Peginterferon alfa-2b|
5822107|NCT00006324|Drug|Ethinyl estradiol/levonorgestrel|
5822108|NCT00006324|Drug|Medroxyprogesterone acetate|
5822109|NCT00006291|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5822110|NCT00006291|Drug|Aldesleukin|
5822111|NCT00006279|Drug|Nevirapine|
5822112|NCT00006211|Drug|Capravirine|
5822113|NCT00006211|Drug|Nelfinavir mesylate|
5822114|NCT00006209|Drug|Tucaresol|
5822115|NCT00006208|Drug|Efavirenz|
5822116|NCT00006208|Drug|Emtricitabine|
5822117|NCT00006208|Drug|Stavudine|
5822118|NCT00006208|Drug|Didanosine|
5822119|NCT00006207|Drug|PRO 2000|
5822120|NCT00006154|Drug|Indinavir sulfate|400 mg tablets equaling 1600 mg daily
5822121|NCT00006154|Drug|Ritonavir|100 mg liquid capsules equaling 400 mg daily
5822122|NCT00006154|Drug|Abacavir sulfate|300 mg capsules equaling 600 mg daily. Administration based on individual results after 16 weeks.
5822123|NCT00006154|Drug|Efavirenz|200 mg capsules equaling 600 mg daily
5822124|NCT00006154|Drug|Stavudine|30-40 mg capsules equaling 60 or 80 mg daily
5822125|NCT00006154|Drug|Didanosine|250-400 mg E.coated tablets equaling 250 or 400 mg daily
5822126|NCT00006154|Drug|Aldesleukin|Subcutaneous injection equaling 15 x 10^6 IU daily dose. Administration based on individual results after 16 weeks and randomization.
5822127|NCT00006153|Biological|HIV-1 Immunogen|
5822128|NCT00006152|Drug|Ritonavir|
5822129|NCT00006152|Drug|Abacavir sulfate|
5822130|NCT00006152|Drug|Amprenavir|
5822131|NCT00006146|Biological|Approved influenza virus vaccine.|
5822132|NCT00006145|Drug|Valganciclovir|
5822133|NCT00006144|Drug|Lopinavir/Ritonavir|
5822134|NCT00006144|Drug|Emtricitabine|
5822135|NCT00006144|Drug|Stavudine|
5822136|NCT00006143|Drug|Somatropin|
5822137|NCT00006075|Drug|Chlorhexidine gluconate|
5822138|NCT00006066|Biological|Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed|
5822139|NCT00006066|Biological|Diphtheria and Tetanus Toxoids Adsorbed|
5822140|NCT00006066|Biological|Tetanus and Diphtheria Toxoids Adsorbed|
5822141|NCT00006066|Drug|Bacteriophage phi X 174|
5822142|NCT00006066|Drug|Aldesleukin|
5822143|NCT00005931|Drug|SU5416|
5822144|NCT00005921|Drug|L-743,872|
5822145|NCT00005920|Drug|L-743,872|
5822146|NCT00005918|Drug|Efavirenz|
5822147|NCT00005918|Drug|Lamivudine|
5822148|NCT00005918|Drug|Stavudine|
5822149|NCT00005779|Drug|Interleukin-12|
5822150|NCT00005779|Biological|HIV-1 C4-V3 Polyvalent Peptide Vaccine|
5822151|NCT00005764|Drug|Lamivudine/Zidovudine|
5822152|NCT00005764|Drug|Abacavir sulfate|
5822153|NCT00005764|Drug|Lamivudine|
5822154|NCT00005762|Drug|Indinavir sulfate|
5822155|NCT00005762|Drug|Ritonavir|
5822156|NCT00005762|Drug|Amprenavir|
5822157|NCT00005762|Drug|Nelfinavir mesylate|
5822158|NCT00005762|Drug|Efavirenz|
5822159|NCT00005762|Drug|Saquinavir|
5822160|NCT00005758|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5822161|NCT00005758|Biological|HIV-1 Immunogen|
5822162|NCT00005668|Drug|Itraconazole oral solution|
5822163|NCT00005663|Drug|Valacyclovir hydrochloride|
5822164|NCT00005120|Drug|Calanolide A|
5822165|NCT00005118|Drug|Indinavir sulfate|
5822166|NCT00005118|Drug|Ritonavir|
5822167|NCT00005113|Drug|Cyclosporine|Oral tablet taken daily. Dosage is dependent on weight and is titrated to target trough level.
5822168|NCT00005113|Drug|Sirolimus|Dosage in liquid or tablet form is dependent on body surface area and is titrated to target trough level.
5822169|NCT00005113|Drug|Tacrolimus|dosage is in oral form titrated to target trough level
5822170|NCT00005106|Drug|Lamivudine/Zidovudine|
5822171|NCT00005106|Drug|Abacavir sulfate|
5822172|NCT00005106|Drug|Nelfinavir mesylate|
5822173|NCT00005106|Drug|Lamivudine|
5822174|NCT00005106|Drug|Stavudine|
5822175|NCT00005018|Drug|Hydroxyurea|
5822176|NCT00005018|Drug|Abacavir sulfate|
5822177|NCT00005018|Drug|Efavirenz|
5822178|NCT00005018|Drug|Didanosine|
5822179|NCT00005017|Drug|Ritonavir|
5822180|NCT00005017|Drug|Abacavir sulfate|
5822185|NCT00005012|Drug|Peginterferon alfa-2b|
5822186|NCT00005010|Drug|Irbesartan|
5822187|NCT00005010|Drug|Pravastatin|
5822188|NCT00005009|Biological|Varivax®|Each participant will receive 2 doses of Varivax 6 to 8 weeks apart.
5822189|NCT00005002|Drug|Lamivudine/Zidovudine|
5822190|NCT00005002|Biological|HIV-1 Immunogen|
5822191|NCT00005002|Drug|Nelfinavir mesylate|
5822192|NCT00005001|Biological|HIV-1 Immunogen|
5822193|NCT00005000|Drug|Nelfinavir mesylate|
5822194|NCT00005000|Drug|Efavirenz|
5822195|NCT00005000|Drug|Lamivudine|
5822196|NCT00005000|Drug|Keyhole-Limpet Hemocyanin|
5822197|NCT00005000|Drug|Stavudine|
5822198|NCT00005000|Drug|Zidovudine|
5822199|NCT00005000|Drug|Didanosine|
5822200|NCT00004999|Drug|Lamivudine/Zidovudine|
5822201|NCT00004999|Drug|Capravirine|
5822202|NCT00004999|Drug|Nelfinavir mesylate|
5822203|NCT00004998|Drug|Lamivudine/Zidovudine|
5822204|NCT00004998|Drug|Capravirine|
5822205|NCT00004998|Drug|Nelfinavir mesylate|
5822206|NCT00004987|Drug|Dextrin 2-sulfate|
5822207|NCT00004986|Drug|Nitazoxanide|
5822208|NCT00004985|Drug|Capravirine|
5822209|NCT00004985|Drug|Nelfinavir mesylate|
5822210|NCT00004981|Drug|Abacavir sulfate, Lamivudine and Zidovudine|
5822211|NCT00004981|Drug|Lamivudine/Zidovudine|
5822212|NCT00004981|Drug|Abacavir sulfate|
5822213|NCT00004978|Drug|Recombinant interleukin-2 (rIL-2)|Recombinant interleukin-2 at a dose of 7.5 MIU given twice daily subcutaneously for 5 consecutive days every 8 weeks for at least 3 cycles.
5822214|NCT00004855|Drug|Lopinavir/Ritonavir|
5822215|NCT00004855|Drug|Abacavir sulfate|
5822216|NCT00004855|Drug|Nevirapine|
5822217|NCT00004855|Drug|Lamivudine|
5822218|NCT00004855|Drug|Stavudine|
5822219|NCT00004852|Drug|Efavirenz|
5822220|NCT00004852|Drug|Lamivudine|
5822221|NCT00004852|Drug|Zidovudine|
5822222|NCT00004736|Drug|Nelfinavir mesylate|
5822223|NCT00004736|Drug|Ethambutol hydrochloride|
5822224|NCT00004736|Drug|Isoniazid|
5822225|NCT00004736|Drug|Pyrazinamide|
5822226|NCT00004736|Drug|Lamivudine|
5822227|NCT00004736|Drug|Rifabutin|
5822228|NCT00004736|Drug|Stavudine|
5822229|NCT00004736|Drug|Zidovudine|
5822230|NCT00004735|Biological|Tetanus toxoid|
5822231|NCT00004735|Biological|Hepatitis A Vaccine (Inactivated)|
5822232|NCT00004585|Drug|Abacavir sulfate, Lamivudine and Zidovudine|
5822233|NCT00004585|Drug|Lamivudine/Zidovudine|
5822234|NCT00004585|Drug|Abacavir sulfate|
5822235|NCT00004585|Drug|Efavirenz|
5822236|NCT00004584|Drug|Atazanavir|
5822237|NCT00004584|Drug|Ritonavir|
5822238|NCT00004584|Drug|Saquinavir|
5822239|NCT00004583|Drug|Lopinavir/Ritonavir|
5822240|NCT00004583|Drug|Nelfinavir mesylate|
5822241|NCT00004583|Drug|Lamivudine|
5822242|NCT00004583|Drug|Stavudine|
5822243|NCT00004582|Drug|Lopinavir/Ritonavir|
5822244|NCT00004582|Drug|Efavirenz|
5822245|NCT00004581|Drug|Lopinavir/Ritonavir|
5822246|NCT00004581|Drug|Nevirapine|
5822247|NCT00004580|Drug|Lopinavir/Ritonavir|
5822248|NCT00004580|Drug|Nevirapine|
5822249|NCT00004579|Biological|gp160 MN/LAI-2|
5822250|NCT00004579|Biological|ALVAC-HIV MN120TMG (vCP205)|
5822251|NCT00004578|Drug|Lopinavir/Ritonavir|Lopinavir, range from 200 mg to 400 mg, every 12 hrs and Ritonavir, range from 100 mg to 200 mg, every 12 hrs
5822252|NCT00004578|Drug|Lamivudine|150 mg, every 12 hours
5822253|NCT00004578|Drug|Stavudine|40 mg every 12 hours
5822254|NCT00002453|Drug|Tenofovir disoproxil fumarate|
5822255|NCT00002452|Drug|L-756423|
5822256|NCT00002452|Drug|Indinavir sulfate|
5822257|NCT00002451|Drug|Indinavir sulfate|
5822258|NCT00002451|Drug|Ritonavir|
5822259|NCT00002451|Drug|Lamivudine|
5822260|NCT00002451|Drug|Stavudine|
5822261|NCT00002450|Drug|Tenofovir disoproxil fumarate|
5822262|NCT00002449|Drug|Aldesleukin|
5822263|NCT00002448|Drug|Ritonavir|
5822264|NCT00002448|Drug|Efavirenz|
5822265|NCT00002448|Drug|Saquinavir|
5822266|NCT00002447|Drug|Ritonavir|
5822267|NCT00002447|Drug|Efavirenz|
5822268|NCT00002447|Drug|Saquinavir|
5822269|NCT00002446|Drug|Posaconazole|
5822270|NCT00002446|Drug|Fluconazole|
5822271|NCT00002445|Drug|IM862|
5822272|NCT00002444|Drug|Nitazoxanide|
5822273|NCT00002443|Drug|Indinavir sulfate|
5822274|NCT00002443|Drug|Zidovudine|
5822275|NCT00002442|Drug|Indinavir sulfate|
5822276|NCT00002442|Drug|Nelfinavir mesylate|
5822277|NCT00002442|Drug|Lamivudine|
5822278|NCT00002442|Drug|Stavudine|
5822279|NCT00002441|Biological|MN rgp120/HIV-1 and GNE8 rgp120/HIV-1|
5822280|NCT00002440|Drug|Indinavir sulfate|
5822281|NCT00002440|Drug|Ritonavir|
5822282|NCT00002440|Drug|Abacavir sulfate|
5822283|NCT00002440|Drug|Amprenavir|
5822284|NCT00002440|Drug|Nelfinavir mesylate|
5822285|NCT00002440|Drug|Saquinavir|
5822286|NCT00002439|Drug|Alitretinoin|
5822287|NCT00002438|Drug|Itraconazole|
5822288|NCT00002437|Drug|Cidofovir|
5822289|NCT00002437|Drug|Probenecid|
5822290|NCT00002436|Drug|Lamivudine|
5822291|NCT00002436|Drug|Zidovudine|
5822292|NCT00002436|Drug|Zalcitabine|
5822293|NCT00002435|Drug|Thymic Humoral Factor|
5822294|NCT00002435|Drug|Zidovudine|
5822295|NCT00002434|Drug|Trimetrexate glucuronate|
5822296|NCT00002434|Drug|Leucovorin calcium|
5822297|NCT00002433|Drug|Interferon gamma-1b|
5822298|NCT00002432|Drug|Foscarnet sodium|
5822299|NCT00002431|Drug|Chlorhexidine gluconate|
5822300|NCT00002430|Drug|Indinavir sulfate|
5822301|NCT00002430|Drug|Nelfinavir mesylate|
5822302|NCT00002430|Drug|Lamivudine|
5822303|NCT00002430|Drug|Stavudine|
5822304|NCT00002429|Drug|Lamivudine/Zidovudine|
5822305|NCT00002429|Drug|Nelfinavir mesylate|
5822306|NCT00002429|Drug|Stavudine|
5822307|NCT00002429|Drug|Didanosine|
5822308|NCT00002428|Biological|HIV-1 Peptide Vaccine, Microparticulate Monovalent|
5822309|NCT00002428|Biological|rgp120/HIV-1MN Monovalent Octameric V3 Peptide Vaccine|
5822310|NCT00002427|Drug|Hydroxyurea|
5822311|NCT00002427|Drug|Stavudine|
5822312|NCT00002427|Drug|Didanosine|
5822313|NCT00002426|Drug|Adefovir dipivoxil|
5822314|NCT00002425|Drug|Saquinavir|
5822315|NCT00002424|Drug|L-756423|
5822316|NCT00002424|Drug|Indinavir sulfate|
5822317|NCT00002424|Drug|Lamivudine|
5822318|NCT00002424|Drug|Stavudine|
5822319|NCT00002423|Drug|Indinavir sulfate|
5822320|NCT00002423|Drug|Abacavir sulfate|
5822321|NCT00002423|Drug|Amprenavir|
5822322|NCT00002423|Drug|Nelfinavir mesylate|
5822323|NCT00002423|Drug|Lamivudine|
5822324|NCT00002422|Drug|HE2000|
5822325|NCT00002420|Drug|Emivirine|
5822326|NCT00002420|Drug|Hydroxyurea|
5822327|NCT00002420|Drug|Delavirdine mesylate|
5822328|NCT00002420|Drug|Stavudine|
5822329|NCT00002420|Drug|Didanosine|
5822330|NCT00002419|Drug|Abacavir sulfate|
5822331|NCT00002419|Drug|Amprenavir|
5822332|NCT00002419|Drug|Efavirenz|
5822333|NCT00002419|Drug|Adefovir dipivoxil|
5822334|NCT00002418|Drug|Emivirine|
5822335|NCT00002418|Drug|Hydroxyurea|
5822336|NCT00002418|Drug|Nevirapine|
5822337|NCT00002418|Drug|Stavudine|
5822338|NCT00002418|Drug|Didanosine|
5822339|NCT00002417|Drug|Amprenavir|
5822340|NCT00002416|Drug|Emtricitabine|
5822341|NCT00002416|Drug|Lamivudine|
5822342|NCT00002415|Drug|Tenofovir disoproxil fumarate|
5822343|NCT00002414|Drug|CPI-1189|
5822344|NCT00002413|Drug|Emivirine|
5822345|NCT00002412|Drug|Emivirine|
5822346|NCT00002412|Drug|Hydroxyurea|
5822347|NCT00002412|Drug|Stavudine|
5822348|NCT00002412|Drug|Didanosine|
5822349|NCT00002411|Drug|Nelfinavir mesylate|
5822350|NCT00002411|Drug|Lamivudine|
5822351|NCT00002411|Drug|Stavudine|
5822352|NCT00002411|Drug|Zidovudine|
5822353|NCT00002411|Drug|Didanosine|
5822354|NCT00002410|Drug|Indinavir sulfate|
5822355|NCT00002410|Drug|Lamivudine|
5822356|NCT00002410|Drug|Zidovudine|
5822357|NCT00002409|Drug|Lamivudine/Zidovudine|
5822358|NCT00002409|Drug|Abacavir sulfate|
5822359|NCT00002408|Drug|Crofelemer|
5822360|NCT00002407|Drug|Indinavir sulfate|
5822361|NCT00002407|Drug|Nevirapine|
5822362|NCT00002407|Drug|Lamivudine|
5822363|NCT00002407|Drug|Stavudine|
5822364|NCT00002407|Drug|Didanosine|
5822365|NCT00002406|Drug|Indinavir sulfate|
5822366|NCT00002405|Drug|Amprenavir|
5822367|NCT00002404|Drug|Valacyclovir hydrochloride|
5822368|NCT00002403|Drug|Zintevir|
5822369|NCT00002402|Biological|MN rgp120/HIV-1 and GNE8 rgp120/HIV-1|
5822370|NCT00002402|Biological|MN rgp120/HIV-1 and A244 rgp120/HIV-1|
5822371|NCT00002402|Biological|Aluminum hydroxide|
5822372|NCT00002401|Drug|Indinavir sulfate|
5822373|NCT00002401|Drug|Delavirdine mesylate|
5822374|NCT00002401|Drug|Lamivudine|
5822375|NCT00002401|Drug|Zidovudine|
5822376|NCT00002400|Drug|Indinavir sulfate|
5822377|NCT00002400|Drug|Delavirdine mesylate|
5822378|NCT00002400|Drug|Lamivudine|
5822379|NCT00002400|Drug|Zidovudine|
5822380|NCT00002399|Drug|Posaconazole|
5822381|NCT00002399|Drug|Fluconazole|
5822382|NCT00002398|Drug|Levocarnitine|
5822383|NCT00002398|Drug|Adefovir dipivoxil|
5822384|NCT00002397|Drug|Nelfinavir mesylate|
5822385|NCT00002397|Drug|Saquinavir|
5822386|NCT00002397|Drug|Lamivudine|
5822387|NCT00002397|Drug|Stavudine|
5822388|NCT00002396|Drug|Tenofovir disoproxil fumarate|
5822389|NCT00002395|Drug|Topotecan|
5822390|NCT00002394|Drug|Terbinafine hydrochloride|
5822391|NCT00002393|Drug|Indinavir sulfate|
5822392|NCT00002393|Drug|Efavirenz|
5822393|NCT00002392|Drug|Thalidomide|
5822394|NCT00002391|Drug|Abacavir sulfate|
5822395|NCT00002391|Drug|Lamivudine|
5822396|NCT00002391|Drug|Zidovudine|
5822397|NCT00002390|Drug|Abacavir sulfate|
5822398|NCT00002389|Drug|Abacavir sulfate|
5822399|NCT00002389|Drug|Lamivudine|
5822400|NCT00002389|Drug|Zidovudine|
5822401|NCT00002388|Drug|Abacavir sulfate|
5822402|NCT00002387|Drug|Indinavir sulfate|
5822403|NCT00002387|Drug|Efavirenz|
5822404|NCT00002386|Drug|Indinavir sulfate|
5822405|NCT00002386|Drug|Lamivudine|
5822406|NCT00002386|Drug|Stavudine|
5822407|NCT00002386|Drug|Zidovudine|
5822408|NCT00002386|Drug|Zalcitabine|
5822409|NCT00002386|Drug|Didanosine|
5822410|NCT00002385|Drug|Fozivudine tidoxil|
5822411|NCT00002384|Drug|Cidofovir|
5822412|NCT00002383|Drug|Saquinavir|
5822413|NCT00002382|Drug|Saquinavir|
5822414|NCT00002381|Drug|Nelfinavir mesylate|
5822415|NCT00002381|Drug|Nevirapine|
5822416|NCT00002381|Drug|Stavudine|
5822417|NCT00002380|Drug|Nelfinavir mesylate|
5822418|NCT00002380|Drug|Saquinavir|
5822419|NCT00002379|Drug|Indinavir sulfate|
5822420|NCT00002379|Drug|Levocarnitine|
5822421|NCT00002379|Drug|Adefovir dipivoxil|
5822426|NCT00002378|Drug|Nelfinavir mesylate|
5822427|NCT00002378|Drug|Saquinavir|
5822428|NCT00002378|Drug|Delavirdine mesylate|
5822429|NCT00002378|Drug|Lamivudine|
5822430|NCT00002378|Drug|Stavudine|
5822431|NCT00002378|Drug|Zidovudine|
5822432|NCT00002377|Drug|Valganciclovir|
5822433|NCT00002377|Drug|Ganciclovir|
5822434|NCT00002376|Drug|Indinavir sulfate|
5822435|NCT00002376|Drug|Lamivudine|
5822436|NCT00002376|Drug|Stavudine|
5822437|NCT00002376|Drug|Zidovudine|
5822438|NCT00002376|Drug|Didanosine|
5822439|NCT00002375|Drug|Indinavir sulfate|
5822440|NCT00002375|Drug|Nelfinavir mesylate|
5822441|NCT00002374|Drug|Ritonavir|
5822442|NCT00002374|Drug|Nelfinavir mesylate|
5822443|NCT00002374|Drug|Saquinavir|
5822444|NCT00002374|Drug|Stavudine|
5822445|NCT00002373|Drug|Maribavir|
5822446|NCT00002372|Drug|Indinavir sulfate|
5822447|NCT00002372|Drug|Amprenavir|
5822448|NCT00002372|Drug|Nelfinavir mesylate|
5822449|NCT00002372|Drug|Saquinavir|
5822450|NCT00002371|Drug|Indinavir sulfate|
5822451|NCT00002371|Drug|Lamivudine|
5822452|NCT00002371|Drug|Stavudine|
5822453|NCT00002371|Drug|Zidovudine|
5822454|NCT00002370|Drug|Itraconazole|
5822455|NCT00002369|Drug|Indinavir sulfate|
5822456|NCT00002369|Drug|Lamivudine|
5822457|NCT00002369|Drug|Stavudine|
5822458|NCT00002369|Drug|Zidovudine|
5822459|NCT00002368|Drug|Nevirapine|
5822460|NCT00002368|Drug|Lamivudine|
5822461|NCT00002367|Drug|Saquinavir|
5822462|NCT00002367|Drug|Lamivudine|
5822463|NCT00002367|Drug|Zidovudine|
5822464|NCT00002366|Drug|Ritonavir|
5822465|NCT00002365|Drug|LXR015-1|
5822466|NCT00002364|Drug|Abacavir sulfate|
5822467|NCT00002363|Drug|Peptide Construction 3, Synthetic|
5822468|NCT00002362|Drug|Abacavir sulfate|
5822469|NCT00002362|Drug|Efavirenz|
5822470|NCT00002362|Drug|Emtricitabine|
5822471|NCT00002362|Drug|Stavudine|
5822472|NCT00002361|Drug|Indinavir sulfate|
5822473|NCT00002361|Drug|Ritonavir|
5822474|NCT00002360|Drug|Didanosine|
5822475|NCT00002359|Biological|HIV-1 Immunogen|
5822476|NCT00002358|Drug|Sorivudine|
5822477|NCT00002357|Drug|HBY 097|
5822478|NCT00002357|Drug|Zidovudine|
5822479|NCT00002356|Drug|Fomivirsen sodium|
5822480|NCT00002355|Drug|Fomivirsen sodium|
5822481|NCT00002354|Drug|Indinavir sulfate|
5822482|NCT00002354|Drug|Stavudine|
5822483|NCT00002353|Biological|P3C541b Lipopeptide|
5822484|NCT00002352|Drug|Lobucavir|
5822485|NCT00002351|Drug|Indinavir sulfate|
5822486|NCT00002350|Biological|APL 400-003|
5822487|NCT00002349|Drug|Stavudine|
5822488|NCT00002348|Drug|Mitoguazone|
5822489|NCT00002347|Drug|Saquinavir|
5822490|NCT00002347|Drug|Nevirapine|
5822491|NCT00002347|Drug|Zidovudine|
5822492|NCT00002347|Drug|Zalcitabine|
5822493|NCT00002346|Drug|Adefovir dipivoxil|
5822494|NCT00002345|Drug|Megestrol acetate|
5822495|NCT00002344|Drug|Azithromycin|
5822496|NCT00002343|Drug|Ethambutol hydrochloride|
5822497|NCT00002343|Drug|Rifabutin|
5822498|NCT00002342|Drug|Tecogalan sodium|
5822499|NCT00002341|Drug|Itraconazole|
5822500|NCT00002340|Drug|Atovaquone|
5822501|NCT00002340|Drug|Pentamidine isethionate|
5822502|NCT00002339|Drug|Fluconazole|
5822503|NCT00002338|Drug|Raluridine|
5822504|NCT00002337|Drug|Vesnarinone|
5822505|NCT00002336|Drug|Clarithromycin|
5822506|NCT00002335|Drug|Emtricitabine|
5822507|NCT00002334|Drug|Saquinavir|
5822508|NCT00002334|Drug|Zidovudine|
5822509|NCT00002334|Drug|Zalcitabine|
5822510|NCT00002333|Drug|Saquinavir|
5822511|NCT00002333|Drug|Zalcitabine|
5822512|NCT00002332|Drug|Thymopentin|
5822513|NCT00002331|Drug|Ethambutol hydrochloride|
5822514|NCT00002331|Drug|Clarithromycin|
5822515|NCT00002331|Drug|Clofazimine|
5822516|NCT00002330|Drug|Ganciclovir|
5822517|NCT00002329|Drug|Celgosivir hydrochloride|
5822518|NCT00002328|Drug|Azithromycin|
5822519|NCT00002327|Drug|Cidofovir|
5822520|NCT00002326|Drug|Adefovir|
5822521|NCT00002326|Drug|Zidovudine|
5822522|NCT00002325|Drug|Fluconazole|
5822523|NCT00002324|Drug|Nevirapine|
5822524|NCT00002324|Drug|Zidovudine|
5822525|NCT00002323|Drug|Nevirapine|
5822526|NCT00002323|Drug|Zidovudine|
5822527|NCT00002322|Drug|Atevirdine mesylate|
5822528|NCT00002322|Drug|Zidovudine|
5822529|NCT00002321|Drug|Aldesleukin|
5822530|NCT00002320|Drug|Lamivudine|
5822531|NCT00002320|Drug|Zidovudine|
5822532|NCT00002319|Drug|Doxorubicin hydrochloride (liposomal)|
5822533|NCT00002318|Drug|Doxorubicin hydrochloride (liposomal)|
5822534|NCT00002318|Drug|Bleomycin sulfate|
5822535|NCT00002318|Drug|Vincristine sulfate|
5822536|NCT00002318|Drug|Doxorubicin hydrochloride|
5822537|NCT00002317|Drug|Trimetrexate glucuronate|
5822538|NCT00002317|Drug|Leucovorin calcium|
5822539|NCT00002316|Drug|Lobradimil|
5822540|NCT00002316|Drug|Amphotericin B|
5822541|NCT00002315|Drug|Netivudine|
5822542|NCT00002315|Drug|Acyclovir|
5822543|NCT00002314|Drug|Ro 24-7429|
5822544|NCT00002313|Drug|Nystatin|
5822545|NCT00002313|Drug|Didanosine|
5822546|NCT00002312|Drug|Delavirdine mesylate|
5822547|NCT00002312|Drug|Zidovudine|
5822548|NCT00002311|Drug|Wobenzym|
5822549|NCT00002310|Drug|Crofelemer|
5822572|NCT00002292|Drug|Pentamidine isethionate|
5822573|NCT00002291|Drug|Pentamidine isethionate|
5822574|NCT00002290|Drug|Zidovudine|
5822575|NCT00002290|Drug|Acyclovir|
5822576|NCT00002289|Drug|Thymopentin|
5822577|NCT00002288|Drug|Zidovudine|
5822578|NCT00002287|Drug|Zidovudine|
5822579|NCT00002286|Drug|Zidovudine|
5822580|NCT00002285|Drug|Zidovudine|
5822581|NCT00002284|Drug|Zidovudine|
5822582|NCT00002283|Drug|Trimethoprim|
5822583|NCT00002283|Drug|Sulfamethoxazole|
5822584|NCT00002283|Drug|Dapsone|
5822585|NCT00002282|Drug|Clotrimazole|
5822586|NCT00002282|Drug|Fluconazole|
5822587|NCT00002281|Drug|Filgrastim|
5822588|NCT00002281|Drug|Epoetin alfa|
5822589|NCT00002281|Drug|Zidovudine|
5822590|NCT00002280|Drug|Didanosine|
5822591|NCT00002279|Drug|Zalcitabine|
5822592|NCT00002278|Drug|Diclazuril|
5822593|NCT00002277|Drug|Fluconazole|
5822594|NCT00002277|Drug|Amphotericin B|
5822595|NCT00002276|Drug|Ibuprofen|
5822596|NCT00002276|Drug|Zidovudine|
5822597|NCT00002275|Drug|Fat Emulsion 2%|
5822598|NCT00002275|Drug|Fat Emulsion 20%|
5822599|NCT00002274|Drug|Didanosine|
5822600|NCT00002273|Drug|Ganciclovir|
5822601|NCT00002272|Drug|Foscarnet sodium|
5822602|NCT00002271|Drug|Alovudine|
5822603|NCT00002270|Drug|Interferon alfa-2b|
5822604|NCT00002270|Drug|Zidovudine|
5822605|NCT00002269|Drug|Ampligen|
5822606|NCT00002269|Drug|Zidovudine|
5822607|NCT00002268|Drug|Sevirumab|
5822608|NCT00002267|Drug|Rifabutin|
5822609|NCT00002266|Drug|AS-101|
5822610|NCT00002265|Drug|Zalcitabine|
5822611|NCT00002264|Drug|Cryptosporidium Immune Whey Protein Concentrate (Bovine)|
5822612|NCT00002263|Drug|Zidovudine|
5822613|NCT00002263|Drug|Sargramostim|
5822614|NCT00002262|Drug|Tumor Necrosis Factor|
5822615|NCT00002261|Biological|Smallpox Vaccine|
5822616|NCT00002261|Biological|HIVAC-1e|
5822617|NCT00002261|Biological|gp160 Vaccine (MicroGeneSys)|
5822618|NCT00002260|Drug|Alovudine|
5822619|NCT00002259|Drug|Mitoxantrone hydrochloride|
5822620|NCT00002258|Drug|Interleukin-3|
5822621|NCT00002257|Drug|Ganciclovir|
5822622|NCT00002256|Drug|Zalcitabine|
5822623|NCT00002255|Drug|Filgrastim|
5822624|NCT00002255|Drug|Epoetin alfa|
5822625|NCT00002255|Drug|Zidovudine|
5822626|NCT00002254|Drug|Alovudine|
5822627|NCT00002253|Drug|Octreotide|
5822628|NCT00002252|Drug|Octreotide|
5822629|NCT00002251|Drug|Ganciclovir|
5822630|NCT00002250|Drug|CD4-IgG|
5822631|NCT00002249|Drug|Levofloxacin|
5822632|NCT00002248|Drug|Cryptosporidium Immune Whey Protein Concentrate (Bovine)|
5822633|NCT00002247|Drug|Ganciclovir|
5822634|NCT00002246|Drug|Stavudine|
5822635|NCT00002245|Drug|Abacavir sulfate|
5822636|NCT00002245|Drug|Amprenavir|
5822637|NCT00002245|Drug|Lamivudine|
5822638|NCT00002244|Drug|WF10|
5822639|NCT00002243|Drug|Calanolide A|
5822640|NCT00002241|Drug|Indinavir sulfate|
5822641|NCT00002241|Drug|Ritonavir|
5822642|NCT00002241|Drug|Lamivudine|
5822643|NCT00002241|Drug|Stavudine|
5822644|NCT00002240|Drug|Atazanavir|
5822645|NCT00002240|Drug|Nelfinavir mesylate|
5822646|NCT00002240|Drug|Stavudine|
5822647|NCT00002240|Drug|Didanosine|
5822648|NCT00002239|Drug|Enfuvirtide|
5822649|NCT00002239|Drug|Ritonavir|
5822650|NCT00002239|Drug|Abacavir sulfate|
5822651|NCT00002239|Drug|Amprenavir|
5822652|NCT00002239|Drug|Efavirenz|
5822653|NCT00002238|Drug|Interferon beta-1b|
5822654|NCT00002238|Drug|Zidovudine|
5822655|NCT00002237|Drug|Peldesine|
5822656|NCT00002236|Drug|Indinavir sulfate|
5822657|NCT00002236|Drug|Delavirdine mesylate|
5822658|NCT00002236|Drug|Zidovudine|
5822659|NCT00002235|Drug|Indinavir sulfate|
5822660|NCT00002235|Drug|Nelfinavir mesylate|
5822661|NCT00002235|Drug|Efavirenz|
5822662|NCT00002234|Drug|Efavirenz|
5822663|NCT00002234|Drug|Adefovir dipivoxil|
5822664|NCT00002234|Drug|Lamivudine|
5822665|NCT00002234|Drug|Didanosine|
5822666|NCT00002233|Drug|Indinavir sulfate|
5822667|NCT00002233|Drug|Abacavir sulfate|
5822668|NCT00002233|Drug|Amprenavir|
5822669|NCT00002233|Drug|Lamivudine|
5822670|NCT00002232|Biological|APL 400-003|
5822671|NCT00002231|Biological|APL 400-003|
5822672|NCT00002230|Drug|Hydroxyurea|
5822673|NCT00002230|Drug|Efavirenz|
5822674|NCT00002230|Drug|Stavudine|
5822675|NCT00002230|Drug|Didanosine|
5822676|NCT00002229|Drug|Saquinavir|
5822677|NCT00002228|Drug|Enfuvirtide|
5822678|NCT00002227|Drug|Efavirenz|
5822679|NCT00002227|Drug|Lamivudine|
5822680|NCT00002227|Drug|Stavudine|
5822681|NCT00002226|Drug|SU5416|
5822682|NCT00002225|Drug|Efavirenz|
5822683|NCT00002225|Drug|Stavudine|
5822684|NCT00002225|Drug|Didanosine|
5822685|NCT00002224|Drug|Nelfinavir mesylate|
5822686|NCT00002224|Drug|Stavudine|
5822687|NCT00002224|Drug|Didanosine|
5822688|NCT00002223|Drug|Indinavir sulfate|
5822689|NCT00002223|Drug|Ritonavir|
5822690|NCT00002222|Drug|Valganciclovir|
5822691|NCT00002221|Drug|Peripheral blood stem cells|
5822692|NCT00002220|Drug|Indinavir sulfate|
5822693|NCT00002220|Drug|Efavirenz|
5822694|NCT00002220|Drug|Levocarnitine|
5822695|NCT00002220|Drug|Adefovir dipivoxil|
5822696|NCT00002219|Drug|Nelfinavir mesylate|
5822700|NCT00002217|Drug|Lamivudine/Zidovudine|
5822701|NCT00002217|Drug|Abacavir sulfate|
5822702|NCT00002217|Drug|Amprenavir|
5822703|NCT00002216|Drug|Lamivudine/Zidovudine|
5822704|NCT00002216|Drug|Abacavir sulfate|
5822705|NCT00002216|Drug|Amprenavir|
5822706|NCT00002216|Drug|Nelfinavir mesylate|
5822707|NCT00002215|Drug|Emivirine|
5822708|NCT00002215|Drug|Nelfinavir mesylate|
5822709|NCT00002214|Drug|Capravirine|
5822710|NCT00002213|Drug|Abacavir sulfate|
5822711|NCT00002213|Drug|Amprenavir|
5822712|NCT00002213|Drug|Efavirenz|
5822713|NCT00002212|Drug|Bexarotene|
5822714|NCT00002211|Drug|Nelfinavir mesylate|
5822715|NCT00002211|Drug|Delavirdine mesylate|
5822716|NCT00002211|Drug|Stavudine|
5822717|NCT00002211|Drug|Didanosine|
5822718|NCT00002210|Drug|Delavirdine mesylate|
5822719|NCT00002209|Drug|CPI-1189|
5822720|NCT00002208|Drug|Indinavir sulfate|
5822721|NCT00002208|Drug|Lamivudine|
5822722|NCT00002208|Drug|Stavudine|
5822723|NCT00002208|Drug|Zidovudine|
5822724|NCT00002207|Drug|Stavudine|
5822725|NCT00002207|Drug|Didanosine|
5822726|NCT00002206|Drug|Adefovir dipivoxil|
5822727|NCT00002205|Drug|Abacavir sulfate|
5822728|NCT00002205|Drug|Amprenavir|
5822729|NCT00002204|Biological|HIV p24/MF59 Vaccine|
5822730|NCT00002203|Drug|Lamivudine/Zidovudine|
5822731|NCT00002203|Drug|Lamivudine|
5822732|NCT00002203|Drug|Zidovudine|
5822733|NCT00002202|Drug|Indinavir sulfate|
5822734|NCT00002202|Drug|Amprenavir|
5822735|NCT00002201|Drug|Ritonavir|
5822736|NCT00002201|Drug|Nelfinavir mesylate|
5822737|NCT00002200|Drug|Abacavir sulfate|
5822738|NCT00002199|Drug|Indinavir sulfate|
5822739|NCT00002199|Drug|Lamivudine/Zidovudine|
5822740|NCT00002199|Drug|Abacavir sulfate|
5822741|NCT00002198|Drug|Abacavir sulfate|
5822742|NCT00002197|Drug|Abacavir sulfate|
5822743|NCT00002196|Drug|CI-1012|
5822744|NCT00002195|Drug|Amprenavir|
5822745|NCT00002195|Drug|Lamivudine|
5822746|NCT00002195|Drug|Zidovudine|
5822747|NCT00002194|Drug|Erythromycin|
5822748|NCT00002194|Drug|Nevirapine|
5822749|NCT00002194|Drug|Clarithromycin|
5822750|NCT00002193|Drug|Amprenavir|
5822751|NCT00002192|Drug|Rifapentine|
5822752|NCT00002192|Drug|Ethambutol hydrochloride|
5822753|NCT00002192|Drug|Clarithromycin|
5822754|NCT00002192|Drug|Azithromycin|
5822755|NCT00002191|Drug|Albendazole|
5822756|NCT00002190|Drug|Saquinavir|
5822757|NCT00002190|Drug|Lamivudine|
5822758|NCT00002190|Drug|Zidovudine|
5822759|NCT00002189|Drug|Paclitaxel|
5822760|NCT00002188|Drug|Alitretinoin|
5822761|NCT00002187|Drug|Fomivirsen sodium|
5822762|NCT00002186|Drug|Crofelemer|
5822763|NCT00002186|Drug|Acyclovir|
5822764|NCT00002185|Drug|Nelfinavir mesylate|
5822765|NCT00002184|Drug|Nelfinavir mesylate|
5822766|NCT00002184|Drug|Levocarnitine|
5822767|NCT00002184|Drug|Adefovir dipivoxil|
5822768|NCT00002184|Drug|Saquinavir|
5822769|NCT00002184|Drug|Lamivudine|
5822770|NCT00002184|Drug|Stavudine|
5822771|NCT00002184|Drug|Zidovudine|
5822772|NCT00002183|Drug|Abacavir sulfate|
5822773|NCT00002183|Drug|Amprenavir|
5822774|NCT00002183|Drug|Lamivudine|
5822775|NCT00002183|Drug|Zidovudine|
5822776|NCT00002182|Drug|Megestrol acetate|
5822777|NCT00002181|Drug|Cidofovir|
5822778|NCT00002180|Drug|Tenofovir|
5822779|NCT00002179|Drug|Indinavir sulfate|
5822780|NCT00002179|Drug|Lamivudine|
5822781|NCT00002179|Drug|Zidovudine|
5822782|NCT00002178|Drug|Ritonavir|
5822783|NCT00002178|Drug|Nelfinavir mesylate|
5822784|NCT00002178|Drug|Saquinavir|
5822785|NCT00002178|Drug|Delavirdine mesylate|
5822786|NCT00002177|Drug|Hydroxyurea|
5822787|NCT00002177|Drug|Nelfinavir mesylate|
5822788|NCT00002177|Drug|Stavudine|
5822789|NCT00002177|Drug|Didanosine|
5822790|NCT00002176|Drug|Hydroxyurea|
5822791|NCT00002176|Drug|Nelfinavir mesylate|
5822792|NCT00002176|Drug|Stavudine|
5822793|NCT00002176|Drug|Didanosine|
5822794|NCT00002175|Drug|Dinitrochlorobenzene|
5822795|NCT00002174|Drug|Thalidomide|
5822796|NCT00002173|Biological|HIV-1 Immunogen|
5822797|NCT00002172|Biological|HIV-1 Immunogen|
5822798|NCT00002171|Drug|Nelfinavir mesylate|
5822799|NCT00002170|Drug|Nelfinavir mesylate|
5822800|NCT00002169|Drug|Nelfinavir mesylate|
5822801|NCT00002168|Drug|Indinavir sulfate|
5822802|NCT00002168|Drug|Lamivudine|
5822803|NCT00002168|Drug|Stavudine|
5822804|NCT00002168|Drug|Zidovudine|
5822805|NCT00002168|Drug|Didanosine|
5822806|NCT00002167|Drug|Tin ethyl etiopurpurin|
5822807|NCT00002166|Drug|Nevirapine|
5822808|NCT00002165|Drug|Nelfinavir mesylate|
5822809|NCT00002164|Drug|Nelfinavir mesylate|
5822810|NCT00002163|Drug|Abacavir sulfate|
5822811|NCT00002162|Drug|Saquinavir|
5822812|NCT00002162|Drug|Lamivudine|
5822813|NCT00002162|Drug|Stavudine|
5822814|NCT00002162|Drug|Zidovudine|
5822815|NCT00002162|Drug|Zalcitabine|
5822816|NCT00002162|Drug|Didanosine|
5822817|NCT00002161|Drug|Adefovir dipivoxil|
5822818|NCT00002160|Drug|Ziconotide|
5822819|NCT00002159|Drug|Itraconazole|
5822820|NCT00002159|Drug|Amphotericin B|
5822821|NCT00002158|Drug|Nitazoxanide|
5822822|NCT00002157|Drug|Thalidomide|
5822829|NCT00002154|Drug|Selegiline hydrochloride|
5822830|NCT00002153|Drug|A-007|
5822831|NCT00002152|Drug|WF10|
5822832|NCT00002151|Drug|Celgosivir hydrochloride|
5822833|NCT00002150|Drug|Celgosivir hydrochloride|
5822834|NCT00002149|Drug|Clavulanate potassium|
5822835|NCT00002149|Drug|Pseudoephedrine hydrochloride|
5822836|NCT00002149|Drug|Amoxicillin trihydrate|
5822837|NCT00002148|Drug|OPC 14117|
5822838|NCT00002147|Drug|Doxorubicin hydrochloride (liposomal)|
5822839|NCT00002146|Drug|Magnesium sulfate|
5822840|NCT00002146|Drug|Foscarnet sodium|
5822841|NCT00002145|Drug|Foscarnet sodium|
5822842|NCT00002144|Drug|Foscarnet sodium|
5822843|NCT00002143|Drug|Acitretin|
5822844|NCT00002142|Drug|Cidofovir|
5822845|NCT00002142|Drug|Probenecid|
5822846|NCT00002141|Drug|Abacavir sulfate|
5822847|NCT00002140|Drug|Ethambutol hydrochloride|
5822848|NCT00002140|Drug|Clarithromycin|
5822849|NCT00002140|Drug|Azithromycin|
5822850|NCT00002139|Drug|Azithromycin|
5822851|NCT00002138|Drug|Tecogalan sodium|
5822852|NCT00002137|Drug|Tecogalan sodium|
5822853|NCT00002136|Drug|Tecogalan sodium|
5822854|NCT00002135|Drug|Ganciclovir|
5822855|NCT00002134|Drug|Ganciclovir|
5822856|NCT00002133|Drug|Itraconazole|
5822857|NCT00002132|Drug|Itraconazole|
5822858|NCT00002132|Drug|Fluconazole|
5822859|NCT00002131|Drug|Vesnarinone|
5822860|NCT00002130|Drug|Vesnarinone|
5822861|NCT00002129|Drug|Vesnarinone|
5822862|NCT00002128|Drug|Adefovir dipivoxil|
5822863|NCT00002127|Drug|Thalidomide|
5822864|NCT00002126|Drug|Filgrastim|
5822865|NCT00002125|Drug|Foscarnet sodium|
5822866|NCT00002124|Drug|Delavirdine mesylate|
5822867|NCT00002124|Drug|Lamivudine|
5822868|NCT00002124|Drug|Zidovudine|
5822869|NCT00002123|Drug|Delavirdine mesylate|
5822870|NCT00002123|Drug|Didanosine|
5822871|NCT00002122|Drug|Azithromycin|
5822872|NCT00002122|Drug|Rifabutin|
5822873|NCT00002122|Drug|Fluconazole|
5822874|NCT00002121|Drug|Diethylhomospermine|
5822875|NCT00002120|Drug|Trimetrexate glucuronate|
5822876|NCT00002120|Drug|Trimethoprim|
5822877|NCT00002120|Drug|Sulfamethoxazole|
5822878|NCT00002120|Drug|Dapsone|
5822879|NCT00002120|Drug|Leucovorin calcium|
5822880|NCT00002119|Drug|WF10|
5822881|NCT00002118|Drug|Zalcitabine|
5822882|NCT00002117|Drug|Zidovudine|
5822883|NCT00002117|Drug|Zalcitabine|
5822884|NCT00002116|Drug|Cidofovir|
5822885|NCT00002115|Drug|Adefovir|
5822886|NCT00002114|Drug|Procysteine|
5822887|NCT00002113|Drug|Flucytosine|
5822888|NCT00002113|Drug|Fluconazole|
5822889|NCT00002112|Drug|Nystatin|
5822890|NCT00002112|Drug|Fluconazole|
5822891|NCT00002111|Drug|Saquinavir|
5822892|NCT00002110|Drug|Cysteamine|
5822893|NCT00002110|Drug|Zidovudine|
5822894|NCT00002109|Drug|Thymopentin|
5822895|NCT00002109|Drug|Stavudine|
5822896|NCT00002109|Drug|Zidovudine|
5822897|NCT00002109|Drug|Zalcitabine|
5822898|NCT00002109|Drug|Didanosine|
5822899|NCT00002108|Drug|Lamivudine|
5822900|NCT00002108|Drug|Zidovudine|
5822901|NCT00002107|Drug|Aldesleukin|
5822902|NCT00002106|Drug|Ranitidine hydrochloride|
5822903|NCT00002105|Drug|Doxorubicin hydrochloride (liposomal)|
5822904|NCT00002105|Drug|Bleomycin sulfate|
5822905|NCT00002105|Drug|Vincristine sulfate|
5822906|NCT00002104|Drug|Thalidomide|
5822907|NCT00002103|Drug|Trimetrexate glucuronate|
5822908|NCT00002103|Drug|Leucovorin calcium|
5822909|NCT00002102|Drug|Trimetrexate glucuronate|
5822910|NCT00002102|Drug|Leucovorin calcium|
5822911|NCT00002101|Drug|Ethambutol hydrochloride|
5822912|NCT00002101|Drug|Clarithromycin|
5822913|NCT00002101|Drug|Rifabutin|
5822914|NCT00002100|Drug|Curdlan sulfate|
5822915|NCT00002099|Drug|Lentinan|
5822916|NCT00002099|Drug|Didanosine|
5822917|NCT00002098|Drug|Lentinan|
5822918|NCT00002098|Drug|Didanosine|
5822919|NCT00002097|Drug|Nystatin|
5822920|NCT00002096|Drug|Zidovudine|
5822921|NCT00002096|Drug|Didanosine|
5822922|NCT00002096|Drug|Ganciclovir|
5822923|NCT00002095|Drug|Ganciclovir|
5822924|NCT00002094|Drug|Atevirdine mesylate|
5822925|NCT00002093|Drug|Daunorubicin (liposomal)|
5822926|NCT00002093|Drug|Bleomycin sulfate|
5822927|NCT00002093|Drug|Vincristine sulfate|
5822928|NCT00002093|Drug|Doxorubicin hydrochloride|
5822929|NCT00002092|Drug|Cimetidine|
5822930|NCT00002091|Drug|Pentoxifylline|
5822931|NCT00002090|Drug|Azithromycin|
5822932|NCT00002089|Drug|Azithromycin|
5822933|NCT00002088|Drug|Saccharomyces boulardii|
5822934|NCT00002087|Drug|Alvircept sudotox|
5822935|NCT00002086|Drug|Zidovudine|
5822936|NCT00002086|Drug|Zalcitabine|
5822937|NCT00002086|Drug|Interferon alfa-n1|
5822938|NCT00002085|Drug|Azithromycin|
5822939|NCT00002084|Drug|Valacyclovir hydrochloride|
5822940|NCT00002084|Drug|Acyclovir|
5822941|NCT00002083|Drug|Peptide T|
5822942|NCT00002082|Drug|Azithromycin|
5822943|NCT00002081|Drug|Zidovudine|
5822944|NCT00002081|Drug|Zalcitabine|
5822945|NCT00002080|Drug|Rifabutin|
5822946|NCT00002079|Drug|Butyldeoxynojirimycin|
5822947|NCT00002079|Drug|Zidovudine|
5822948|NCT00002078|Drug|Interferon alfa-n3|
5822949|NCT00002077|Drug|Fluconazole|
5822976|NCT00002056|Drug|Pentamidine isethionate|
5822977|NCT00002055|Drug|Pentamidine isethionate|
5822978|NCT00002054|Drug|Pentamidine isethionate|
5822979|NCT00002053|Drug|Pentamidine isethionate|
5822980|NCT00002052|Drug|Ceftriaxone sodium|
5822981|NCT00002052|Drug|Ampicillin sodium|
5822982|NCT00002052|Drug|Amoxicillin trihydrate|
5822983|NCT00002051|Drug|Thymopentin|
5822984|NCT00002050|Drug|Thymopentin|
5822985|NCT00002049|Drug|Thymopentin|
5822986|NCT00002048|Drug|Zidovudine|
5822987|NCT00002047|Drug|Zidovudine|
5822988|NCT00002046|Drug|Zidovudine|
5822989|NCT00002045|Drug|Zidovudine|
5822990|NCT00002044|Drug|Zidovudine|
5822991|NCT00002043|Drug|Dapsone|
5822992|NCT00002042|Drug|Epoetin alfa|
5822993|NCT00002041|Drug|Amphotericin B|
5822994|NCT00002040|Drug|Fluconazole|
5822995|NCT00002039|Drug|Foscarnet sodium|
5822996|NCT00002038|Drug|Fluconazole|
5822997|NCT00002037|Drug|Trifluridine|
5822998|NCT00002036|Drug|Anti-HIV Immune Serum Globulin (Human)|
5822999|NCT00002035|Drug|Zidovudine|
5823000|NCT00002035|Drug|Didanosine|
5823001|NCT00002034|Drug|Zidovudine|
5823002|NCT00002034|Drug|Ganciclovir|
5823003|NCT00002033|Drug|Zidovudine|
5823004|NCT00002033|Drug|AS-101|
5823005|NCT00002032|Drug|Rifabutin|
5823006|NCT00002031|Drug|Dinitrochlorobenzene|
5823007|NCT00002030|Drug|Pentamidine isethionate|
5823008|NCT00002029|Drug|Fat Emulsion 2%|
5823009|NCT00002029|Drug|Fat Emulsion 20%|
5823010|NCT00002028|Drug|Didanosine|
5823011|NCT00002027|Drug|Diclazuril|
5823012|NCT00002026|Drug|Acyclovir|
5823013|NCT00002025|Drug|Ganciclovir|
5823014|NCT00002024|Drug|Ganciclovir|
5823015|NCT00002023|Drug|Zidovudine|
5823016|NCT00002022|Drug|Epoetin alfa|
5823017|NCT00002021|Drug|Foscarnet sodium|
5823018|NCT00002020|Drug|Zidovudine|
5823019|NCT00002019|Drug|Amphotericin B, Lipid-based|
5823020|NCT00002019|Drug|Amphotericin B|
5823021|NCT00002018|Drug|Interferon alfa-n3|
5823022|NCT00002017|Drug|Interleukin-2, Polyethylene Glycolated|
5823023|NCT00002016|Drug|Sevirumab|
5823024|NCT00002015|Drug|Ganciclovir|
5823025|NCT00002014|Drug|Zidovudine|
5823026|NCT00002014|Drug|Didanosine|
5823027|NCT00002013|Drug|Zidovudine|
5823028|NCT00002013|Drug|AS-101|
5823029|NCT00002012|Drug|Interferon alfa-n3|
5823030|NCT00002011|Drug|Methoxsalen|
5823031|NCT00002010|Drug|Fluconazole|
5823032|NCT00002009|Drug|Sargramostim|
5823033|NCT00002008|Drug|Sargramostim|
5823034|NCT00002007|Drug|Zidovudine|
5823035|NCT00002007|Drug|Sargramostim|
5823036|NCT00002006|Drug|Zidovudine|
5823037|NCT00002006|Drug|Sargramostim|
5823038|NCT00002005|Drug|CD4 Antigens|
5823039|NCT00002004|Drug|CD4 Antigens|
5823040|NCT00002003|Drug|Mitoxantrone hydrochloride|
5823041|NCT00002003|Drug|Etoposide|
5823042|NCT00002002|Drug|Trimethoprim|
5823043|NCT00002002|Drug|Sulfamethoxazole|
5823044|NCT00002002|Drug|Leucovorin calcium|
5823045|NCT00002001|Drug|Zidovudine|
5823046|NCT00002001|Drug|Zalcitabine|
5823047|NCT00002001|Drug|Didanosine|
5823048|NCT00002000|Drug|Valacyclovir hydrochloride|
5823049|NCT00002000|Drug|Acyclovir|
5823050|NCT00001999|Drug|Globulin, Immune|
5823051|NCT00001999|Drug|Ganciclovir|
5823052|NCT00001998|Drug|Nystatin|
5823053|NCT00001997|Drug|Interleukin-2, Polyethylene Glycolated|
5823054|NCT00001997|Drug|Zidovudine|
5823055|NCT00001997|Drug|Didanosine|
5823056|NCT00001996|Drug|Atovaquone|
5823057|NCT00001996|Drug|Pentamidine isethionate|
5823058|NCT00001995|Drug|Rifabutin|
5823059|NCT00001994|Drug|Atovaquone|
5823060|NCT00001993|Drug|Butyldeoxynojirimycin|
5823061|NCT00001993|Drug|Zidovudine|
5823062|NCT00001992|Biological|rgp120/HIV-1IIIB|
5823063|NCT00001991|Drug|Atovaquone|
5823064|NCT00001990|Drug|Atovaquone|
5823065|NCT00001989|Drug|Trichosanthin|
5823066|NCT00001989|Drug|Zidovudine|
5823067|NCT00001136|Biological|ALVAC-HIV MN120TMG (vCP205)|
5823068|NCT00001135|Drug|Nevirapine|
5823069|NCT00001133|Drug|Indinavir sulfate|
5823070|NCT00001133|Drug|Ritonavir|
5823071|NCT00001132|Drug|Abacavir sulfate|
5823072|NCT00001131|Drug|Aldesleukin|Subcutaneous injection of IL-2 in the amount of 2.0 X 10^6 mIU per day for the entire duration of therapy
5823073|NCT00001131|Drug|HAART|Current HAART regimen to be continued for duration of therapy or until certain criteria specified by the study is met
5823074|NCT00001129|Device|Electronic Medication Reminder System|
5823075|NCT00001129|Behavioral|Medication Manager|
5823076|NCT00001128|Drug|Interleukin-12|
5823077|NCT00001128|Drug|Paromomycin sulfate|
5823078|NCT00001128|Drug|Azithromycin|
5823079|NCT00001127|Biological|Influenza virus vaccine (CAIV-T)|
5823080|NCT00001126|Drug|Cidofovir|
5823081|NCT00001125|Biological|Varicella Virus Vaccine (Live)|
5823082|NCT00001123|Drug|Ribavirin|
5823083|NCT00001122|Drug|Nelfinavir mesylate|
5823084|NCT00001122|Drug|Efavirenz|
5823085|NCT00001122|Drug|Stavudine|
5823086|NCT00001122|Drug|Didanosine|
5823087|NCT00001119|Biological|Tetanus Toxoid Vaccine|
5823088|NCT00001119|Drug|Indinavir sulfate|
5823089|NCT00001119|Drug|Lamivudine/Zidovudine|
5823090|NCT00001119|Drug|Ritonavir|
5823091|NCT00001119|Drug|Abacavir sulfate|
5823092|NCT00001119|Drug|Amprenavir|
5823094|NCT00001119|Biological|Hepatitis B Vaccine (Recombinant)|
5823095|NCT00001119|Drug|Lamivudine|
5823096|NCT00001119|Drug|Zidovudine|
5823097|NCT00001118|Drug|Enfuvirtide|
5823098|NCT00001116|Drug|Tumor Necrosis Factor soluble receptor-immunoadhesin complex|
5823099|NCT00001115|Drug|Acyclovir|
5823100|NCT00001114|Drug|Interferon alfa-2b|
5823101|NCT00001114|Drug|Didanosine|
5823102|NCT00001113|Drug|Interferon alfa-2a|
5823103|NCT00001113|Drug|Zidovudine|
5823104|NCT00001113|Drug|Interferon alfa-n1|
5823105|NCT00001112|Drug|Zidovudine|
5823106|NCT00001112|Drug|Interferon gamma-1b|
5823107|NCT00001111|Drug|Nevirapine|
5823108|NCT00001111|Drug|Zidovudine|
5823109|NCT00001110|Procedure|Bronchoalveolar lavage|
5823110|NCT00001108|Drug|Ritonavir|
5823111|NCT00001108|Drug|Nelfinavir mesylate|
5823112|NCT00001108|Drug|Saquinavir|
5823113|NCT00001108|Drug|Nevirapine|
5823114|NCT00001108|Drug|Lamivudine|
5823115|NCT00001108|Drug|Stavudine|
5823116|NCT00001108|Drug|Didanosine|
5823117|NCT00001107|Drug|Fluconazole|
5823118|NCT00001107|Drug|AmBisome|
5823119|NCT00001106|Drug|Zidovudine|
5823120|NCT00001105|Drug|F105 Monoclonal Antibody (Human)|
5823121|NCT00001104|Drug|Zidovudine|
5823122|NCT00001101|Drug|ceftriaxone|
5823123|NCT00001101|Drug|doxycycline|
5823124|NCT00001100|Drug|ganciclovir|
5823125|NCT00001096|Biological|MN rgp120/HIV-1 and A244 rgp120/HIV-1|
5823126|NCT00001096|Biological|QS-21|
5823127|NCT00001096|Biological|rgp120/HIV-1MN|
5823128|NCT00001095|Drug|Indinavir sulfate|
5823129|NCT00001095|Drug|Amprenavir|
5823130|NCT00001095|Drug|Nevirapine|
5823131|NCT00001095|Drug|Lamivudine|
5823132|NCT00001095|Drug|Stavudine|
5823133|NCT00001095|Drug|Zidovudine|
5823134|NCT00001094|Drug|Lamivudine/Zidovudine|
5823135|NCT00001094|Drug|Nelfinavir mesylate|
5823136|NCT00001094|Drug|Saquinavir|
5823137|NCT00001094|Drug|Delavirdine mesylate|
5823138|NCT00001091|Drug|Ritonavir|
5823139|NCT00001091|Drug|Nelfinavir mesylate|
5823140|NCT00001091|Drug|Nevirapine|
5823141|NCT00001091|Drug|Lamivudine|
5823142|NCT00001091|Drug|Stavudine|
5823143|NCT00001090|Biological|APL 400-047|
5823144|NCT00001090|Biological|ALVAC-HIV MN120TMG (vCP205)|
5823145|NCT00001090|Drug|Sargramostim|
5823146|NCT00001088|Biological|APL 400-047|
5823147|NCT00001088|Drug|Bupivacaine hydrochloride|
5823148|NCT00001087|Drug|Ritonavir|
5823149|NCT00001087|Drug|Nelfinavir mesylate|
5823150|NCT00001087|Drug|Efavirenz|
5823151|NCT00001087|Drug|Levocarnitine|
5823152|NCT00001087|Drug|Adefovir dipivoxil|
5823153|NCT00001087|Drug|Saquinavir|
5823154|NCT00001087|Drug|Lamivudine|
5823155|NCT00001087|Drug|Stavudine|
5823156|NCT00001087|Drug|Zidovudine|
5823157|NCT00001087|Drug|Zalcitabine|
5823158|NCT00001087|Drug|Didanosine|
5823159|NCT00001086|Drug|Indinavir sulfate|
5823160|NCT00001086|Drug|Abacavir sulfate|
5823161|NCT00001086|Drug|Efavirenz|
5823162|NCT00001085|Drug|Amprenavir|
5823163|NCT00001085|Drug|Lamivudine|
5823164|NCT00001085|Drug|Zidovudine|
5823165|NCT00001084|Drug|Indinavir sulfate|
5823166|NCT00001084|Drug|Lamivudine|
5823167|NCT00001084|Drug|Stavudine|
5823168|NCT00001084|Drug|Zidovudine|
5823169|NCT00001083|Drug|Indinavir sulfate|
5823170|NCT00001083|Drug|Ritonavir|
5823171|NCT00001083|Drug|Nevirapine|
5823172|NCT00001083|Drug|Lamivudine|
5823173|NCT00001083|Drug|Stavudine|
5823174|NCT00001083|Drug|Zidovudine|
5823175|NCT00001082|Drug|Levocarnitine|500 mg tablet taken orally daily
5823176|NCT00001082|Drug|Adefovir dipivoxil|120 mg tablet taken orally daily
5823177|NCT00001082|Drug|Adefovir dipivoxil placebo|Oral placebo tablet taken daily
5823178|NCT00001081|Drug|Nitazoxanide|
5823179|NCT00001080|Biological|Influenza Virus Vaccine|
5823180|NCT00001080|Biological|Pneumococcal Vaccine, Polyvalent (23-valent)|
5823181|NCT00001080|Drug|Lamivudine|
5823182|NCT00001079|Drug|Testosterone enanthate|
5823183|NCT00001079|Drug|Megestrol acetate|
5823184|NCT00001078|Biological|Hepatitis A Vaccine (Inactivated)|
5823185|NCT00001077|Dietary Supplement|Multivitamin and mineral supplements|Oral tablets taken daily
5823186|NCT00001077|Dietary Supplement|Peptamen|Solution received daily
5823187|NCT00001077|Dietary Supplement|NuBasics|Solution or dietary bar received daily
5823188|NCT00001076|Biological|ALVAC-HIV MN120TMG (vCP205)|
5823189|NCT00001076|Biological|ALVAC-RG Rabies Glycoprotein (vCP65)|
5823190|NCT00001076|Biological|rgp120/HIV-1 SF-2|
5823191|NCT00001075|Drug|Ritonavir|
5823192|NCT00001075|Drug|Lamivudine|
5823193|NCT00001075|Drug|Zidovudine|
5823194|NCT00001074|Drug|Hydroxyurea|
5823195|NCT00001074|Drug|Didanosine|
5823196|NCT00001073|Drug|Isotretinoin|
5823197|NCT00001072|Biological|ALVAC-HIV MN120TMGNP (vCP300)|
5823198|NCT00001072|Biological|ALVAC-RG Rabies Glycoprotein (vCP65)|
5823199|NCT00001072|Biological|rgp120/HIV-1 SF-2|
5823200|NCT00001071|Drug|Filgrastim|
5823201|NCT00001070|Drug|Oral Vitamin C|
5823202|NCT00001068|Drug|Lamivudine|
5823203|NCT00001067|Drug|Lamivudine|
5823204|NCT00001067|Drug|Stavudine|
5823205|NCT00001067|Drug|Zidovudine|
5823206|NCT00001066|Drug|Lamivudine|
5823207|NCT00001066|Drug|Zidovudine|
5823208|NCT00001066|Drug|Didanosine|
5823209|NCT00001065|Drug|Amphotericin B|
5823210|NCT00001064|Drug|Allogenic Dendritic Cells|
5823218|NCT00001060|Biological|HIV-1 C4-V3 Polyvalent Peptide Vaccine|
5823219|NCT00001059|Drug|Doxorubicin hydrochloride (liposomal)|
5823220|NCT00001059|Drug|Filgrastim|
5823221|NCT00001059|Drug|Bleomycin sulfate|
5823222|NCT00001059|Drug|Vincristine sulfate|
5823223|NCT00001058|Drug|Indinavir sulfate|
5823224|NCT00001058|Drug|Ritonavir|
5823225|NCT00001058|Drug|Ethambutol hydrochloride|
5823226|NCT00001058|Drug|Clarithromycin|
5823227|NCT00001058|Drug|Rifabutin|
5823228|NCT00001057|Drug|Zidovudine|
5823229|NCT00001057|Drug|Didanosine|
5823230|NCT00001056|Biological|gp160 Vaccine (Immuno-AG)|
5823231|NCT00001055|Biological|ALVAC-HIV MN120TMG (vCP205)|
5823232|NCT00001055|Biological|ALVAC-RG Rabies Glycoprotein (vCP65)|
5823233|NCT00001055|Biological|rgp120/HIV-1 SF-2|
5823234|NCT00001054|Drug|Valacyclovir hydrochloride|
5823235|NCT00001053|Biological|HIV p17/p24:Ty-VLP|
5823236|NCT00001053|Biological|Aluminum hydroxide|
5823237|NCT00001052|Biological|Aluminum hydroxide|
5823238|NCT00001052|Biological|QS-21|
5823239|NCT00001052|Biological|rgp120/HIV-1MN|
5823240|NCT00001049|Drug|Zidovudine|
5823241|NCT00001049|Drug|Didanosine|
5823242|NCT00001048|Drug|Filgrastim|
5823243|NCT00001048|Drug|Cytarabine|
5823244|NCT00001048|Drug|Zidovudine|
5823245|NCT00001048|Drug|Zalcitabine|
5823246|NCT00001048|Drug|Didanosine|
5823247|NCT00001047|Drug|Ethambutol hydrochloride|
5823248|NCT00001047|Drug|Clarithromycin|
5823249|NCT00001047|Drug|Clofazimine|
5823250|NCT00001047|Drug|Rifabutin|
5823251|NCT00001046|Biological|MF59|
5823252|NCT00001046|Biological|rgp120/HIV-1 SF-2|
5823253|NCT00001045|Drug|Nevirapine|
5823254|NCT00001045|Drug|Zidovudine|
5823255|NCT00001045|Drug|Didanosine|
5823256|NCT00001044|Biological|Aluminum hydroxide|
5823257|NCT00001044|Biological|QS-21|
5823258|NCT00001044|Biological|rgp120/HIV-1MN|
5823259|NCT00001043|Biological|gp160 Vaccine (Immuno-AG)|
5823260|NCT00001042|Biological|Aluminum hydroxide|
5823261|NCT00001042|Biological|Lipid A, Monophosphoryl|
5823262|NCT00001042|Biological|Lipid A, Liposome-encapsulated monophosphoryl|
5823263|NCT00001042|Biological|Syntex adjuvant formulation|
5823264|NCT00001042|Biological|MF59|
5823265|NCT00001042|Biological|Threonyl Muramyl Dipeptide|
5823266|NCT00001042|Biological|rgp120/HIV-1 SF-2|
5823267|NCT00001042|Biological|MTP-PE/MF59|
5823268|NCT00001041|Biological|rgp120/HIV-1MN|
5823269|NCT00001040|Drug|Saquinavir|
5823270|NCT00001040|Drug|Zidovudine|
5823271|NCT00001040|Drug|Zalcitabine|
5823272|NCT00001039|Drug|Ethambutol hydrochloride|
5823273|NCT00001039|Drug|Clarithromycin|
5823274|NCT00001038|Drug|Valacyclovir hydrochloride|
5823275|NCT00001038|Drug|Acyclovir|
5823276|NCT00001037|Biological|gp160 Vaccine (Immuno-AG)|
5823277|NCT00001036|Drug|Thymalfasin|
5823278|NCT00001036|Drug|Interleukin-2, Polyethylene Glycolated|
5823279|NCT00001036|Drug|Zidovudine|
5823280|NCT00001035|Drug|Interferon alfa-2b|
5823281|NCT00001035|Drug|Zidovudine|
5823282|NCT00001035|Drug|Zalcitabine|
5823283|NCT00001035|Drug|Didanosine|
5823284|NCT00001034|Drug|Ganciclovir|
5823285|NCT00001033|Drug|Ethambutol hydrochloride|
5823286|NCT00001033|Drug|Isoniazid|
5823287|NCT00001033|Drug|Pyrazinamide|
5823288|NCT00001033|Drug|Pyridoxine hydrochloride|
5823289|NCT00001033|Drug|Levofloxacin|
5823290|NCT00001033|Drug|Rifampin|
5823291|NCT00001032|Drug|Zidovudine|
5823292|NCT00001032|Drug|Zalcitabine|
5823293|NCT00001031|Biological|rgp120/HIV-1MN|
5823294|NCT00001031|Biological|rgp120/HIV-1 SF-2|
5823295|NCT00001030|Drug|Clarithromycin|
5823296|NCT00001030|Drug|Rifabutin|
5823297|NCT00001029|Drug|Zidovudine|
5823298|NCT00001029|Drug|Zalcitabine|
5823299|NCT00001029|Drug|Didanosine|
5823300|NCT00001028|Drug|Pentamidine isethionate|
5823301|NCT00001028|Drug|Dapsone|
5823302|NCT00001027|Drug|Pentamidine isethionate|
5823303|NCT00001026|Biological|gp160 Vaccine (Immuno-AG)|
5823304|NCT00001026|Biological|rgp120/HIV-1IIIB|
5823305|NCT00001026|Biological|rgp120/HIV-1MN|
5823306|NCT00001026|Biological|rgp120/HIV-1 SF-2|
5823307|NCT00001026|Biological|HIVAC-1e|
5823308|NCT00001025|Drug|Zidovudine|
5823309|NCT00001025|Drug|Didanosine|
5823310|NCT00001024|Drug|Zidovudine|
5823311|NCT00001024|Drug|Didanosine|
5823312|NCT00001023|Drug|Clarithromycin|
5823313|NCT00001023|Drug|Azithromycin|
5823314|NCT00001023|Drug|Rifabutin|
5823315|NCT00001022|Drug|Zidovudine|
5823316|NCT00001022|Drug|Zalcitabine|
5823317|NCT00001022|Drug|Didanosine|
5823318|NCT00001021|Biological|rgp120/HIV-1IIIB|
5823319|NCT00001021|Biological|rgp120/HIV-1MN|
5823320|NCT00001020|Biological|rgp120/HIV-1IIIB|
5823321|NCT00001020|Biological|rgp120/HIV-1MN|
5823322|NCT00001019|Biological|rgp120/HIV-1 SF-2|
5823323|NCT00001019|Biological|MTP-PE/MF59|
5823324|NCT00001018|Drug|Letrazuril|
5823325|NCT00001017|Drug|Fluconazole|
5823326|NCT00001017|Drug|Amphotericin B|
5823327|NCT00001016|Drug|Trimetrexate glucuronate|
5823328|NCT00001016|Drug|Leucovorin calcium|
5823329|NCT00001015|Drug|Ribavirin|
5823330|NCT00001014|Drug|Trimetrexate glucuronate|
5823331|NCT00001014|Drug|Sulfamethoxazole-Trimethoprim|
5823332|NCT00001014|Drug|Leucovorin calcium|
5823333|NCT00001013|Drug|Trimetrexate glucuronate|
5823334|NCT00001013|Drug|Pentamidine isethionate|
5823335|NCT00001013|Drug|Sulfamethoxazole-Trimethoprim|
5823336|NCT00001013|Drug|Leucovorin calcium|
5823337|NCT00001012|Drug|AL 721|
5823338|NCT00001011|Drug|Zidovudine|
5823339|NCT00001010|Drug|Zidovudine|
5823340|NCT00001010|Drug|Acyclovir|
5823341|NCT00001009|Drug|Dextran sulfate|
5823342|NCT00001008|Drug|Methadone hydrochloride|
5823343|NCT00001008|Drug|Zidovudine|
5823344|NCT00001007|Drug|Zidovudine|
5823345|NCT00001006|Drug|AS-101|
5823346|NCT00001005|Drug|Zidovudine|
5823347|NCT00001005|Drug|Aldesleukin|
5823348|NCT00001004|Drug|Tumor Necrosis Factor|
5823349|NCT00001004|Drug|Interferon gamma-1b|
5823350|NCT00001003|Drug|Pentamidine isethionate|
5823351|NCT00001003|Drug|Zidovudine|
5823352|NCT00001002|Drug|Zidovudine|
5823353|NCT00001002|Drug|Foscarnet sodium|
5823354|NCT00001001|Drug|Zidovudine|
5823355|NCT00001000|Drug|Ampligen|
5823356|NCT00000999|Drug|Zidovudine|
5823357|NCT00000998|Drug|Trimetrexate glucuronate|
5823358|NCT00000998|Drug|Leucovorin calcium|
5823359|NCT00000997|Drug|Zalcitabine|
5823360|NCT00000996|Drug|Doxorubicin hydrochloride|
5823361|NCT00000995|Drug|Zidovudine|
5823362|NCT00000995|Drug|Ganciclovir|
5823363|NCT00000994|Drug|Zidovudine|
5823364|NCT00000993|Drug|Zidovudine|
5823365|NCT00000992|Drug|Itraconazole|
5823366|NCT00000991|Drug|Pentamidine isethionate|
5823367|NCT00000991|Drug|Sulfamethoxazole-Trimethoprim|
5823368|NCT00000991|Drug|Dapsone|
5823369|NCT00000991|Drug|Zidovudine|
5823370|NCT00000990|Drug|Zidovudine|
5823371|NCT00000989|Drug|Zidovudine|
5823372|NCT00000989|Drug|Sargramostim|
5823373|NCT00000989|Drug|Ganciclovir|
5823374|NCT00000988|Drug|Stavudine|
5823375|NCT00000987|Drug|Bleomycin sulfate|
5823376|NCT00000987|Drug|Vincristine sulfate|
5823377|NCT00000987|Drug|Doxorubicin hydrochloride|
5823378|NCT00000987|Drug|Zidovudine|
5823379|NCT00000986|Drug|Zidovudine|
5823380|NCT00000986|Drug|Aldesleukin|
5823381|NCT00000985|Drug|Vidarabine|
5823382|NCT00000985|Drug|Acyclovir|
5823383|NCT00000985|Drug|Foscarnet sodium|
5823384|NCT00000984|Drug|CD4 Antigens|
5823385|NCT00000983|Drug|Zidovudine|
5823386|NCT00000982|Drug|Zidovudine|
5823387|NCT00000982|Drug|Didanosine|
5823388|NCT00000981|Drug|Fiacitabine|
5823389|NCT00000980|Drug|Spiramycin|
5823390|NCT00000979|Drug|Zidovudine|
5823391|NCT00000979|Drug|Didanosine|
5823392|NCT00000978|Drug|Zidovudine|
5823393|NCT00000978|Drug|Zalcitabine|
5823394|NCT00000977|Biological|gp160 Vaccine (MicroGeneSys)|
5823395|NCT00000976|Drug|CD4-IgG|
5823396|NCT00000976|Drug|Zidovudine|
5823397|NCT00000975|Drug|Itraconazole|
5823398|NCT00000974|Drug|Pentamidine isethionate|
5823399|NCT00000973|Drug|Pyrimethamine|
5823400|NCT00000973|Drug|Leucovorin calcium|
5823401|NCT00000973|Drug|Zidovudine|
5823402|NCT00000972|Biological|MTP-PE/MF59|
5823403|NCT00000972|Biological|Env 2-3|
5823404|NCT00000971|Drug|Clarithromycin|
5823405|NCT00000971|Drug|Zidovudine|
5823406|NCT00000971|Drug|Didanosine|
5823407|NCT00000970|Drug|Foscarnet sodium|
5823408|NCT00000970|Drug|Ganciclovir|
5823409|NCT00000969|Drug|Zalcitabine|
5823410|NCT00000969|Drug|Didanosine|
5823411|NCT00000968|Biological|gp160 Vaccine (Immuno-AG)|
5823412|NCT00000967|Drug|Interferon alfa-2a|
5823413|NCT00000967|Drug|Zidovudine|
5823414|NCT00000966|Drug|Azithromycin|
5823415|NCT00000966|Drug|Pyrimethamine|
5823416|NCT00000966|Drug|Leucovorin calcium|
5823417|NCT00000965|Drug|Zidovudine|
5823418|NCT00000964|Drug|Ranitidine hydrochloride|
5823419|NCT00000964|Drug|Foscarnet sodium|
5823420|NCT00000963|Drug|Didanosine|
5823421|NCT00000962|Drug|Nevirapine|
5823422|NCT00000961|Drug|Anti-HIV Immune Serum Globulin (Human)|
5823423|NCT00000961|Drug|Zidovudine|
5823424|NCT00000960|Drug|Zidovudine|
5823425|NCT00000959|Drug|Isoniazid|
5823426|NCT00000959|Drug|Pyridoxine hydrochloride|
5823427|NCT00000958|Biological|MTP-PE/MF59|
5823428|NCT00000958|Biological|Env 2-3|
5823429|NCT00000957|Biological|gp160 Vaccine (Immuno-AG)|
5823430|NCT00000956|Biological|gp160 Vaccine (MicroGeneSys)|
5823431|NCT00000955|Drug|Tuberculin Purified Protein Derivative|Administered intradermally at 5 TU per 0.1 mL
5823432|NCT00000954|Drug|Bleomycin sulfate|
5823433|NCT00000954|Drug|Vincristine sulfate|
5823434|NCT00000954|Drug|Doxorubicin hydrochloride|
5823435|NCT00000954|Drug|Zalcitabine|
5823436|NCT00000954|Drug|Didanosine|
5823437|NCT00000953|Drug|Sorivudine|
5823438|NCT00000953|Drug|Acyclovir|
5823439|NCT00000952|Drug|Ritonavir|
5823440|NCT00000952|Drug|Lamivudine|
5823441|NCT00000952|Drug|Zidovudine|
5823442|NCT00000951|Drug|Fluconazole|
5823443|NCT00000950|Drug|Ethambutol hydrochloride|
5823444|NCT00000950|Drug|Isoniazid|
5823445|NCT00000950|Drug|Pyrazinamide|
5823446|NCT00000950|Drug|Pyridoxine hydrochloride|
5823447|NCT00000950|Drug|Rifampin|
5823448|NCT00000949|Drug|Aldesleukin|
5823449|NCT00000948|Drug|Aldesleukin|Il-2
5823450|NCT00000948|Drug|ART|antiretroviral therapy for the treatment of HIV
5823451|NCT00000947|Drug|Azithromycin|
5823452|NCT00000946|Biological|HIV p24/MF59 Vaccine|
5823453|NCT00000946|Biological|ALVAC-HIV MN120TMG (vCP205)|
5823454|NCT00000946|Biological|ALVAC-RG Rabies Glycoprotein (vCP65)|
5823455|NCT00000946|Biological|rgp120/HIV-1 SF-2|
5823456|NCT00000945|Drug|Cidofovir|
5823457|NCT00000945|Drug|Probenecid|
5823458|NCT00000944|Drug|Indinavir sulfate|
5823459|NCT00000944|Drug|Lamivudine|
5823460|NCT00000944|Drug|Zidovudine|
5823461|NCT00000943|Biological|Tetanus Toxoid Vaccine|
5823462|NCT00000943|Biological|Hepatitis A Vaccine (Inactivated)|
5823463|NCT00000943|Biological|HIV-1 Immunogen|
5823464|NCT00000943|Biological|Hepatitis B Vaccine (Recombinant)|
5823465|NCT00000942|Drug|Nevirapine|
5823466|NCT00000941|Drug|Pravastatin sodium|
5823467|NCT00000941|Drug|Simvastatin|
5823468|NCT00000941|Drug|Atorvastatin calcium|
5823469|NCT00000941|Drug|Ritonavir|
5823470|NCT00000941|Drug|Nelfinavir mesylate|
5823471|NCT00000941|Drug|Saquinavir|
5823472|NCT00000940|Drug|Ritonavir|
5823473|NCT00000940|Drug|Abacavir sulfate|
5823474|NCT00000940|Drug|Amprenavir|
5823475|NCT00000940|Drug|Lamivudine|
5823476|NCT00000940|Drug|Stavudine|
5823477|NCT00000939|Drug|Hydroxyurea|
5823478|NCT00000939|Drug|Efavirenz|
5823479|NCT00000939|Drug|Stavudine|
5823480|NCT00000939|Drug|Didanosine|
5823481|NCT00000938|Drug|ceftriaxone|
5823482|NCT00000938|Drug|doxycycline|
5823483|NCT00000937|Drug|Antibiotics|
5823484|NCT00000936|Drug|hOKT3|Administered both during and after transplantation in IV form. Dosage determined by individual weight and given for a maximum of 14 days.
5823485|NCT00000936|Drug|Oral Cyclosporine|Administered orally as either sandimmune or neoral at a dose determined by weight. Patients 6 years of age and older begin at a dose of 15 mg/kg/day and patients under 6 years of age receive 500 mg/m2/day, for the duration of the study.
5823486|NCT00000936|Drug|IV Cyclosporine|Administered intravenously (IV) both during and after transplantation at a dosage determined by individual age.
5823487|NCT00000935|Biological|Intravenous immune globulin (IVIG)|given at a dose of 20mL/kg Intravenous Immune Globulin (Human) (IVIG 10% solvent/detergent)
5823488|NCT00000931|Behavioral|Behavioral intervention|
5823489|NCT00000931|Behavioral|Risk-reduction counseling|
5823490|NCT00000929|Drug|Nonoxynol-9|
5823491|NCT00000928|Behavioral|Group counseling intervention|Participants will engage in a multi-session group-based condom promotion program for approximately 12 months
5823492|NCT00000927|Drug|BufferGel|
5823493|NCT00000926|Drug|Nonoxynol-9|
5823494|NCT00000925|Drug|Optimune oral nutritional supplement|
5823495|NCT00000924|Drug|Ritonavir|
5823496|NCT00000924|Drug|Nelfinavir mesylate|
5823497|NCT00000924|Drug|Nevirapine|
5823498|NCT00000924|Drug|Stavudine|
5823499|NCT00000924|Drug|Didanosine|
5823500|NCT00000923|Drug|Indinavir sulfate|
5823501|NCT00000923|Drug|Lamivudine|
5823502|NCT00000923|Drug|Stavudine|
5823503|NCT00000923|Drug|Zidovudine|
5823504|NCT00000923|Drug|Didanosine|
5823505|NCT00000923|Drug|Aldesleukin|
5823506|NCT00000922|Drug|Indinavir sulfate|
5823507|NCT00000922|Drug|Abacavir sulfate|
5823508|NCT00000922|Drug|Nelfinavir mesylate|
5823509|NCT00000922|Drug|Efavirenz|
5823510|NCT00000922|Drug|Nevirapine|
5823511|NCT00000922|Drug|Lamivudine|
5823512|NCT00000922|Drug|Stavudine|
5823513|NCT00000922|Drug|Didanosine|
5823514|NCT00000921|Drug|Prednisone|
5823515|NCT00000920|Drug|Ritonavir|
5823516|NCT00000920|Drug|Saquinavir|
5823517|NCT00000920|Drug|Lamivudine|
5823518|NCT00000920|Drug|Zidovudine|
5823519|NCT00000919|Drug|Indinavir sulfate|
5823520|NCT00000919|Drug|Lamivudine/Zidovudine|
5823521|NCT00000919|Drug|Ritonavir|
5823522|NCT00000919|Drug|Hydroxyurea|
5823523|NCT00000919|Drug|Abacavir sulfate|
5823524|NCT00000919|Drug|Amprenavir|
5823525|NCT00000919|Drug|Nelfinavir mesylate|
5823526|NCT00000919|Drug|Efavirenz|
5823527|NCT00000919|Drug|Lamivudine|
5823528|NCT00000919|Drug|Stavudine|
5823529|NCT00000919|Drug|Zidovudine|
5823530|NCT00000919|Drug|Didanosine|
5823531|NCT00000918|Drug|Indinavir sulfate|
5823532|NCT00000918|Drug|Lamivudine/Zidovudine|
5823533|NCT00000918|Drug|Ritonavir|
5823534|NCT00000918|Drug|Amprenavir|
5823535|NCT00000918|Drug|Efavirenz|
5823536|NCT00000918|Drug|Saquinavir|
5823537|NCT00000918|Drug|Lamivudine|
5823538|NCT00000918|Drug|Stavudine|
5823539|NCT00000918|Drug|Zidovudine|
5823540|NCT00000918|Drug|Didanosine|
5823541|NCT00000916|Drug|Indinavir sulfate|
5823542|NCT00000916|Drug|Lamivudine/Zidovudine|
5823543|NCT00000916|Drug|Hydroxyurea|
5823544|NCT00000916|Drug|Lamivudine|
5823545|NCT00000916|Drug|Stavudine|
5823546|NCT00000916|Drug|Zidovudine|
5823547|NCT00000916|Drug|Didanosine|
5823548|NCT00000915|Behavioral|Vaccine preparedness|
5823549|NCT00000914|Drug|Indinavir sulfate|
5823550|NCT00000914|Drug|Ritonavir|
5823551|NCT00000914|Drug|Nelfinavir mesylate|
5823552|NCT00000914|Drug|Efavirenz|
5823553|NCT00000913|Drug|Ritonavir|
5823554|NCT00000913|Drug|Nelfinavir mesylate|
5823555|NCT00000913|Drug|Saquinavir|
5823556|NCT00000912|Drug|Indinavir sulfate|
5823557|NCT00000912|Drug|Abacavir sulfate|
5823558|NCT00000912|Drug|Amprenavir|
5823559|NCT00000912|Drug|Nelfinavir mesylate|
5823560|NCT00000912|Drug|Efavirenz|
5823561|NCT00000912|Drug|Levocarnitine|
5823562|NCT00000912|Drug|Adefovir dipivoxil|
5823563|NCT00000912|Drug|Saquinavir|
5823564|NCT00000909|Drug|Aldesleukin|
5823565|NCT00000906|Drug|Ritonavir|
5823567|NCT00000906|Drug|Methadone hydrochloride|
5823568|NCT00000904|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5823569|NCT00000904|Biological|gp160 MN/LAI-2|
5823570|NCT00000904|Biological|ALVAC(1)120(B,MN)GNP (vCP1433)|
5823571|NCT00000904|Biological|ALVAC-HIV MN120TMG (vCP205)|
5823572|NCT00000904|Biological|ALVAC-RG Rabies Glycoprotein (vCP65)|
5823573|NCT00000903|Drug|Indinavir sulfate|
5823574|NCT00000903|Drug|Lamivudine/Zidovudine|
5823575|NCT00000903|Drug|Nelfinavir mesylate|
5823576|NCT00000903|Drug|Efavirenz|
5823577|NCT00000902|Drug|Ritonavir|
5823578|NCT00000902|Drug|Nelfinavir mesylate|
5823579|NCT00000902|Drug|Nevirapine|
5823580|NCT00000902|Drug|Lamivudine|
5823581|NCT00000902|Drug|Stavudine|
5823582|NCT00000902|Drug|Zidovudine|
5823583|NCT00000902|Drug|Zalcitabine|
5823584|NCT00000902|Drug|Didanosine|
5823585|NCT00000901|Drug|Indinavir sulfate|
5823586|NCT00000901|Drug|Lamivudine|
5823587|NCT00000901|Drug|Stavudine|
5823588|NCT00000899|Drug|Nelfinavir mesylate|
5823589|NCT00000899|Drug|Lamivudine|
5823590|NCT00000899|Drug|Filgrastim|
5823591|NCT00000899|Drug|Stavudine|
5823592|NCT00000899|Drug|Cyclophosphamide|
5823593|NCT00000898|Drug|Ritonavir|
5823594|NCT00000898|Drug|Nelfinavir mesylate|
5823595|NCT00000898|Drug|Saquinavir|
5823596|NCT00000897|Drug|Zidovudine|
5823597|NCT00000896|Drug|Indinavir sulfate|
5823598|NCT00000896|Drug|Lamivudine/Zidovudine|
5823599|NCT00000896|Biological|Hepatitis A Vaccine (Inactivated)|
5823600|NCT00000896|Drug|Interleukin-12|
5823601|NCT00000896|Drug|Nevirapine|
5823602|NCT00000896|Drug|Stavudine|
5823603|NCT00000896|Drug|Sargramostim|
5823604|NCT00000895|Drug|Nelfinavir mesylate|
5823605|NCT00000895|Drug|Nevirapine|
5823606|NCT00000895|Drug|Azithromycin|
5823607|NCT00000894|Drug|Cidofovir|
5823608|NCT00000894|Drug|Probenecid|
5823609|NCT00000894|Drug|Ganciclovir|
5823610|NCT00000893|Drug|Nelfinavir mesylate|
5823611|NCT00000893|Drug|Efavirenz|
5823612|NCT00000892|Drug|Ritonavir|
5823613|NCT00000892|Drug|Nelfinavir mesylate|
5823614|NCT00000892|Drug|Levocarnitine|
5823615|NCT00000892|Drug|Adefovir dipivoxil|
5823616|NCT00000892|Drug|Saquinavir|
5823617|NCT00000892|Drug|Delavirdine mesylate|
5823618|NCT00000891|Drug|Ritonavir|
5823619|NCT00000891|Drug|Saquinavir|
5823620|NCT00000891|Drug|Delavirdine mesylate|
5823621|NCT00000891|Drug|Lamivudine|
5823622|NCT00000891|Drug|Stavudine|
5823623|NCT00000891|Drug|Zidovudine|
5823624|NCT00000891|Drug|Didanosine|
5823625|NCT00000889|Drug|Aldesleukin|
5823626|NCT00000888|Drug|Ritonavir|
5823627|NCT00000888|Drug|Lamivudine|
5823628|NCT00000888|Drug|Zidovudine|
5823629|NCT00000887|Drug|Nelfinavir mesylate|
5823630|NCT00000887|Drug|Lamivudine|
5823631|NCT00000887|Drug|Zidovudine|
5823632|NCT00000886|Biological|HIV-1 C4-V3 Polyvalent Peptide Vaccine|
5823633|NCT00000885|Drug|Indinavir sulfate|
5823634|NCT00000885|Drug|Abacavir sulfate|
5823635|NCT00000885|Drug|Nelfinavir mesylate|
5823636|NCT00000885|Drug|Efavirenz|
5823637|NCT00000885|Drug|Levocarnitine|
5823638|NCT00000885|Drug|Adefovir dipivoxil|
5823639|NCT00000885|Drug|Lamivudine|
5823640|NCT00000885|Drug|Stavudine|
5823641|NCT00000885|Drug|Zidovudine|
5823642|NCT00000885|Drug|Didanosine|
5823643|NCT00000884|Biological|MN rgp120/HIV-1 and GNE8 rgp120/HIV-1|Dosage will vary based on route of administration
5823644|NCT00000884|Biological|ALVAC-HIV MN120TMG (vCP205)|Dosage will vary based on route of administration
5823645|NCT00000884|Biological|ALVAC-RG Rabies Glycoprotein (vCP65)|Dosage will vary based on route of administration
5823646|NCT00000883|Drug|Azithromycin|
5823647|NCT00000882|Drug|Indinavir sulfate|
5823648|NCT00000882|Drug|Delavirdine mesylate|
5823649|NCT00000882|Drug|Lamivudine|
5823650|NCT00000882|Drug|Stavudine|
5823651|NCT00000882|Drug|Zidovudine|
5823652|NCT00000881|Drug|Cidofovir|
5823653|NCT00000881|Drug|Probenecid|
5823654|NCT00000880|Drug|Cyclosporine|
5823655|NCT00000879|Biological|ALVAC(2)120(B,MN)GNP (vCP1452)|
5823656|NCT00000879|Biological|MN rgp120/HIV-1 and GNE8 rgp120/HIV-1|
5823657|NCT00000879|Biological|ALVAC-HIV MN120TMG (vCP205)|
5823658|NCT00000878|Drug|Lamivudine|
5823659|NCT00000878|Drug|Stavudine|
5823660|NCT00000878|Drug|Zidovudine|
5823661|NCT00000877|Drug|Indinavir sulfate|
5823662|NCT00000877|Drug|Rifabutin|
5823663|NCT00000876|Drug|CD4-IgG2|
5823664|NCT00000875|Drug|Indinavir sulfate|
5823665|NCT00000875|Drug|Diphenhydramine hydrochloride|
5823666|NCT00000875|Drug|Lymphocytes, Activated|
5823667|NCT00000875|Drug|Lamivudine|
5823668|NCT00000875|Drug|Zidovudine|
5823669|NCT00000875|Drug|Acetaminophen|
5823670|NCT00000875|Drug|Aldesleukin|
5823671|NCT00000873|Drug|Infant Formula|
5823672|NCT00000872|Drug|Abacavir sulfate|
5823673|NCT00000872|Drug|Nelfinavir mesylate|
5823674|NCT00000872|Drug|Nevirapine|
5823675|NCT00000872|Drug|Lamivudine|
5823676|NCT00000872|Drug|Stavudine|
5823677|NCT00000872|Drug|Zidovudine|
5823678|NCT00000871|Biological|MN rgp120/HIV-1 and GNE8 rgp120/HIV-1|
5823679|NCT00000871|Biological|MN rgp120/HIV-1 and A244 rgp120/HIV-1|
5823680|NCT00000871|Biological|ALVAC-HIV MN120TMG (vCP205)|
5823681|NCT00000871|Biological|rgp120/HIV-1 SF-2|
5823682|NCT00000870|Drug|Indinavir sulfate|
5823689|NCT00000868|Biological|Salmonella typhi CVD 908-HIV-1 LAI gp 120 (VVG 203)|
5823690|NCT00000868|Biological|Aluminum hydroxide|
5823691|NCT00000868|Biological|MF59|
5823692|NCT00000868|Biological|rgp120/HIV-1MN|
5823693|NCT00000867|Drug|Memantine|
5823694|NCT00000866|Biological|MN rgp120/HIV-1|
5823695|NCT00000866|Biological|TBC-3B Vaccine|
5823696|NCT00000865|Drug|Abacavir sulfate|
5823697|NCT00000865|Drug|Lamivudine|
5823698|NCT00000865|Drug|Stavudine|
5823699|NCT00000865|Drug|Zidovudine|
5823700|NCT00000865|Drug|Didanosine|
5823701|NCT00000864|Drug|Abacavir sulfate|
5823702|NCT00000864|Drug|Zidovudine|
5823703|NCT00000863|Drug|Sitamaquine|
5823704|NCT00000862|Drug|Zidovudine|
5823705|NCT00000861|Drug|Indinavir sulfate|
5823706|NCT00000859|Drug|Indinavir sulfate|
5823707|NCT00000859|Drug|Ritonavir|
5823708|NCT00000859|Drug|Nelfinavir mesylate|
5823709|NCT00000857|Drug|Interleukin-12|
5823710|NCT00000856|Drug|Foscarnet sodium|
5823711|NCT00000856|Drug|Ganciclovir|
5823712|NCT00000855|Drug|Zidovudine|
5823713|NCT00000854|Drug|Nandrolone decanoate|
5823714|NCT00000853|Biological|rgp120/HIV-1MN|
5823715|NCT00000852|Procedure|Allogeneic lymphocyte transfer|
5823716|NCT00000851|Drug|Stavudine|
5823717|NCT00000851|Drug|Didanosine|
5823718|NCT00000850|Drug|Indinavir sulfate|
5823719|NCT00000850|Drug|Sargramostim|
5823720|NCT00000849|Drug|Aldesleukin|
5823721|NCT00000848|Drug|Indinavir sulfate|
5823722|NCT00000848|Drug|Saquinavir|
5823723|NCT00000847|Biological|ALVAC-HIV MN120TMG (vCP205)|
5823724|NCT00000847|Biological|ALVAC-RG Rabies Glycoprotein (vCP65)|
5823725|NCT00000847|Biological|rgp120/HIV-1 SF-2|
5823726|NCT00000846|Biological|HIV-1 Peptide Vaccine, Microparticulate Monovalent|
5823727|NCT00000846|Biological|HIV-1 Peptide Immunogen, Multivalent|
5823728|NCT00000845|Biological|P3C541b Lipopeptide|
5823729|NCT00000844|Drug|Interferon alfa-n3|
5823730|NCT00000844|Drug|Interferon alfa-n1|
5823731|NCT00000843|Drug|Adefovir dipivoxil|
5823732|NCT00000842|Drug|Nerve Growth Factor, Recombinant Human|
5823733|NCT00000841|Drug|Indinavir sulfate|
5823734|NCT00000841|Drug|Lamivudine|
5823735|NCT00000841|Drug|Stavudine|
5823736|NCT00000841|Drug|Zidovudine|
5823737|NCT00000839|Drug|Didanosine|
5823738|NCT00000838|Drug|Lamivudine|
5823739|NCT00000838|Drug|Stavudine|
5823740|NCT00000838|Drug|Zidovudine|
5823741|NCT00000838|Drug|Didanosine|
5823742|NCT00000837|Biological|Varicella Virus Vaccine (Live)|
5823743|NCT00000836|Drug|Sevirumab|
5823744|NCT00000834|Drug|Lamivudine|
5823745|NCT00000834|Drug|Methotrexate|
5823746|NCT00000834|Drug|Zidovudine|
5823747|NCT00000833|Drug|Ribavirin|
5823748|NCT00000833|Drug|Didanosine|
5823749|NCT00000832|Biological|MF59|
5823750|NCT00000832|Biological|rgp120/HIV-1 SF-2|
5823751|NCT00000831|Drug|Lamivudine|
5823752|NCT00000831|Drug|Stavudine|
5823753|NCT00000831|Drug|Zidovudine|
5823754|NCT00000831|Drug|Didanosine|
5823755|NCT00000829|Biological|Pneumococcal Vaccine, Polyvalent (23-valent)|Administered as an injection at 24 months of age
5823756|NCT00000829|Biological|Pneumococcal Conjugate Vaccine, Heptavalent|Administered as an injection at 0, 2, 4, and 15 months of age
5823757|NCT00000829|Biological|Placebo|Administered at 0, 2, 4, and 15 months of age
5823758|NCT00000827|Drug|Anti-HIV Immune Serum Globulin (Human)|
5823759|NCT00000826|Drug|Clarithromycin|
5823760|NCT00000826|Drug|Rifabutin|
5823761|NCT00000826|Drug|Sulfamethoxazole-Trimethoprim|
5823762|NCT00000826|Drug|Dapsone|
5823763|NCT00000826|Drug|Fluconazole|
5823764|NCT00000825|Drug|Aldesleukin|
5823765|NCT00000824|Drug|Lymphocytes, Activated|
5823766|NCT00000823|Drug|Zidovudine|
5823767|NCT00000823|Drug|Didanosine|
5823768|NCT00000822|Drug|Ritonavir|
5823769|NCT00000822|Biological|gp160 Vaccine (Immuno-AG)|
5823770|NCT00000822|Drug|Stavudine|
5823771|NCT00000822|Drug|Didanosine|
5823772|NCT00000821|Drug|Aldesleukin|
5823773|NCT00000820|Drug|Aldesleukin|
5823774|NCT00000819|Drug|Prednisone|
5823775|NCT00000818|Drug|Zidovudine|
5823776|NCT00000817|Drug|Amitriptyline hydrochloride|75 mg oral tablet taken daily
5823777|NCT00000817|Drug|Amitriptyline hydrochloride placebo|Oral placebo tablet taken daily
5823778|NCT00000817|Procedure|Point acupuncture|Standardized or alternate acupuncture procedure
5823779|NCT00000816|Drug|Sulfamethoxazole-Trimethoprim|
5823780|NCT00000815|Biological|Attenuvax|Measles virus vaccine (attenuate)administered subcutaneously at a single dose of 0.5 mL at 6 months of age
5823781|NCT00000815|Biological|M-M-R-II|Measles-Mumps-Rubella vaccine (attenuated)administered subcutaneously as a single dose of 0.5 mL at 12 months of age
5823782|NCT00000814|Drug|Nevirapine|
5823783|NCT00000814|Drug|Zidovudine|
5823784|NCT00000814|Drug|Didanosine|
5823785|NCT00000813|Biological|ALVAC-HIV gp160MN (vCP125)|
5823786|NCT00000813|Biological|ALVAC-RG Rabies Glycoprotein (vCP65)|
5823787|NCT00000813|Biological|rgp120/HIV-1 SF-2|
5823788|NCT00000812|Drug|Thalidomide|
5823789|NCT00000811|Drug|Azithromycin|
5823790|NCT00000811|Drug|Atovaquone|
5823791|NCT00000811|Drug|Sulfamethoxazole-Trimethoprim|
5823792|NCT00000810|Drug|Delavirdine mesylate|
5823793|NCT00000810|Drug|Zidovudine|
5823794|NCT00000810|Drug|Didanosine|
5823795|NCT00000809|Biological|Aluminum hydroxide|
5823796|NCT00000809|Biological|QS-21|
5823797|NCT00000809|Biological|MN rsgp120/HIV-1|
5823803|NCT00000803|Drug|Delavirdine mesylate|
5823804|NCT00000803|Drug|Zidovudine|
5823805|NCT00000803|Drug|Didanosine|
5823806|NCT00000802|Drug|Atovaquone|
5823807|NCT00000802|Drug|Dapsone|
5823808|NCT00000801|Drug|Filgrastim|
5823809|NCT00000801|Drug|Vincristine sulfate|
5823810|NCT00000801|Drug|Doxorubicin hydrochloride|
5823811|NCT00000801|Drug|Cyclophosphamide|
5823812|NCT00000801|Drug|Cytarabine|
5823813|NCT00000801|Drug|Dexamethasone|
5823814|NCT00000800|Drug|Methadone hydrochloride|
5823815|NCT00000800|Drug|Zidovudine|
5823816|NCT00000799|Drug|Cidofovir|
5823817|NCT00000799|Drug|Probenecid|
5823818|NCT00000798|Biological|HIV-1 Peptide Vaccine, Microparticulate Monovalent|
5823819|NCT00000796|Drug|Cycloserine|
5823820|NCT00000796|Drug|Ethionamide|
5823821|NCT00000796|Drug|Capreomycin sulfate|
5823822|NCT00000796|Drug|Aminosalicylic acid|
5823823|NCT00000796|Drug|Streptomycin sulfate|
5823824|NCT00000796|Drug|Ethambutol hydrochloride|
5823825|NCT00000796|Drug|Amikacin sulfate|
5823826|NCT00000796|Drug|Isoniazid|
5823827|NCT00000796|Drug|Pyrazinamide|
5823828|NCT00000796|Drug|Pyridoxine hydrochloride|
5823829|NCT00000796|Drug|Levofloxacin|
5823830|NCT00000796|Drug|Rifampin|
5823831|NCT00000796|Drug|Clofazimine|
5823832|NCT00000795|Biological|HIV-1 Peptide Immunogen, Multivalent|
5823833|NCT00000794|Drug|Sulfadiazine|
5823834|NCT00000794|Drug|Clarithromycin|
5823835|NCT00000794|Drug|Atovaquone|
5823836|NCT00000794|Drug|Pyrimethamine|
5823837|NCT00000794|Drug|Leucovorin calcium|
5823838|NCT00000793|Drug|Mexiletine hydrochloride|
5823839|NCT00000793|Drug|Benztropine mesylate|
5823840|NCT00000793|Drug|Amitriptyline hydrochloride|
5823841|NCT00000792|Drug|Hypericin|
5823842|NCT00000791|Drug|Glycovir|
5823843|NCT00000791|Drug|Zidovudine|
5823844|NCT00000790|Drug|Thalidomide|
5823845|NCT00000789|Drug|Stavudine|
5823846|NCT00000789|Drug|Zidovudine|
5823847|NCT00000788|Drug|Methadone hydrochloride|
5823848|NCT00000788|Drug|Fluconazole|
5823849|NCT00000787|Behavioral|Pre- and post-test counseling|
5823850|NCT00000782|Biological|gp160 Vaccine (Immuno-AG)|
5823851|NCT00000782|Biological|gp160 Vaccine (MicroGeneSys)|
5823852|NCT00000781|Drug|Nevirapine|
5823853|NCT00000781|Drug|Zidovudine|
5823854|NCT00000781|Drug|Zalcitabine|
5823855|NCT00000781|Drug|Didanosine|
5823856|NCT00000779|Biological|Aluminum hydroxide|
5823857|NCT00000779|Biological|MF59|
5823858|NCT00000779|Biological|rgp120/HIV-1IIIB|
5823859|NCT00000779|Biological|rgp120/HIV-1MN|
5823860|NCT00000779|Biological|rgp120/HIV-1 SF-2|
5823861|NCT00000779|Biological|Env 2-3|
5823862|NCT00000778|Drug|Isoniazid|
5823863|NCT00000778|Drug|Pyridoxine hydrochloride|
5823864|NCT00000778|Drug|Levofloxacin|
5823865|NCT00000777|Biological|gp160 Vaccine (MicroGeneSys)|
5823866|NCT00000776|Drug|Flucytosine|
5823867|NCT00000776|Drug|Fluconazole|
5823868|NCT00000776|Drug|Amphotericin B|
5823869|NCT00000776|Drug|Dexamethasone|
5823870|NCT00000775|Biological|rgp120/HIV-1MN Monovalent Octameric V3 Peptide Vaccine|
5823871|NCT00000774|Biological|rgp120/HIV-1MN|Administered at weeks 0, 4, 8, 12, and 20. Individual group assignment will determine specific dosage and schedule.
5823872|NCT00000774|Biological|rgp120/HIV-1 SF-2|Administered at weeks 0, 4, 8, 12, and 20. Individual group assignment will determine specific dosage and schedule.
5823873|NCT00000774|Biological|Placebo version of rgp120/HIV-1MN|Administered at weeks 0, 4, 8, 12, and 20. Individual group assignment will determine specific dosage and schedule.
5823874|NCT00000774|Biological|Placebo version of rgp120/HIV-1SF2|Administered at weeks 0, 4, 8, 12, and 20. Individual group assignment will determine specific dosage and schedule.
5823875|NCT00000773|Drug|Atovaquone|
5823876|NCT00000772|Drug|Ribavirin|
5823877|NCT00000772|Drug|Didanosine|
5823878|NCT00000771|Drug|Paromomycin sulfate|
5823879|NCT00000770|Drug|Nevirapine|
5823880|NCT00000770|Drug|Zidovudine|
5823881|NCT00000770|Drug|Didanosine|
5823882|NCT00000769|Drug|Interleukin-4|
5823883|NCT00000768|Drug|Glutamic acid hydrochloride|
5823884|NCT00000768|Drug|Ganciclovir|
5823885|NCT00000767|Biological|TBC-3B Vaccine|
5823886|NCT00000767|Biological|Smallpox Vaccine|
5823887|NCT00000766|Drug|Foscarnet sodium|
5823888|NCT00000766|Drug|Ganciclovir|
5823889|NCT00000765|Drug|Zidovudine|
5823890|NCT00000764|Drug|Isotretinoin|
5823891|NCT00000764|Drug|Interferon alfa-2a|
5823892|NCT00000763|Drug|TNP-470|
5823893|NCT00000762|Biological|rgp120/HIV-1MN|
5823894|NCT00000762|Biological|rgp120/HIV-1 SF-2|
5823895|NCT00000762|Biological|gp160 Vaccine (MicroGeneSys)|
5823896|NCT00000761|Drug|Interferon gamma-1b|
5823897|NCT00000760|Drug|Ro 24-7429|
5823898|NCT00000760|Drug|Zidovudine|
5823899|NCT00000760|Drug|Didanosine|
5823900|NCT00000758|Drug|Fluorouracil|
5823901|NCT00000757|Biological|gp160 Vaccine (MicroGeneSys)|
5823902|NCT00000756|Drug|Lymphocytes, Activated|
5823903|NCT00000755|Biological|rgp120/HIV-1MN|
5823904|NCT00000755|Drug|Zidovudine|
5823905|NCT00000754|Drug|Interferon alfa-2a|
5823906|NCT00000754|Drug|Zidovudine|
5823907|NCT00000754|Drug|Zalcitabine|
5823908|NCT00000753|Drug|Atevirdine mesylate|
5823909|NCT00000753|Drug|Zidovudine|
5823910|NCT00000753|Drug|Zalcitabine|
5823911|NCT00000753|Drug|Didanosine|
5823912|NCT00000752|Drug|Pseudoephedrine hydrochloride|
5823913|NCT00000752|Drug|Guaifenesin|
5823914|NCT00000752|Drug|Cefuroxime axetil|
5823915|NCT00000752|Drug|Beclomethasone dipropionate|
5823916|NCT00000751|Drug|Anti-HIV Immune Serum Globulin (Human)|
5823917|NCT00000751|Drug|Globulin, Immune|
5823918|NCT00000751|Drug|Zidovudine|
5823919|NCT00000750|Drug|Zidovudine|
5823920|NCT00000749|Biological|rgp120/HIV-1 SF-2|
5823921|NCT00000748|Drug|Sulfamethoxazole-Trimethoprim|
5823922|NCT00000747|Drug|Nevirapine|
5823923|NCT00000746|Biological|rgp120/HIV-1 SF-2|
5823924|NCT00000746|Biological|Env 2-3|
5823925|NCT00000746|Biological|HIVAC-1e|
5823926|NCT00000746|Biological|gp160 Vaccine (MicroGeneSys)|
5823927|NCT00000745|Biological|Hepatitis B Vaccine (Recombinant)|
5823928|NCT00000745|Biological|gp160 Vaccine (MicroGeneSys)|
5823929|NCT00000744|Drug|Fluconazole|
5823930|NCT00000743|Drug|Alvircept sudotox|
5823931|NCT00000743|Drug|Zidovudine|
5823932|NCT00000742|Drug|Atevirdine mesylate|
5823933|NCT00000742|Drug|Zidovudine|
5823934|NCT00000742|Drug|Didanosine|
5823935|NCT00000741|Drug|Methylprednisolone|
5823936|NCT00000740|Drug|Sitamaquine|
5823937|NCT00000739|Drug|Dapsone|
5823938|NCT00000738|Drug|Nimodipine|
5823939|NCT00000738|Drug|Zidovudine|
5823940|NCT00000737|Drug|Dronabinol|
5823941|NCT00000737|Drug|Megestrol acetate|
5823942|NCT00000736|Drug|Zidovudine|
5823943|NCT00000735|Drug|Ampligen|
5823944|NCT00000734|Drug|Sulfamethoxazole-Trimethoprim|
5823945|NCT00000734|Drug|Zidovudine|
5823946|NCT00000733|Drug|Ribavirin|
5823947|NCT00000732|Drug|Sulfamethoxazole-Trimethoprim|
5823948|NCT00000732|Drug|Zidovudine|
5823949|NCT00000731|Drug|Zidovudine|
5823950|NCT00000731|Drug|Acetaminophen|
5823951|NCT00000730|Drug|Trimetrexate glucuronate|
5823952|NCT00000730|Drug|Methylprednisolone|
5823953|NCT00000730|Drug|Pentamidine isethionate|
5823954|NCT00000730|Drug|Sulfamethoxazole-Trimethoprim|
5823955|NCT00000730|Drug|Leucovorin calcium|
5823956|NCT00000729|Drug|Foscarnet sodium|
5823957|NCT00000728|Drug|Zidovudine|
5823958|NCT00000728|Drug|Aldesleukin|
5823959|NCT00000727|Drug|Pentamidine isethionate|
5823960|NCT00000727|Drug|Pyrimethamine|
5823961|NCT00000727|Drug|Sulfamethoxazole/Trimethoprim|
5823962|NCT00000727|Drug|Sulfadoxine/Pyrimethamine|
5823963|NCT00000727|Drug|Zidovudine|
5823964|NCT00000726|Drug|Foscarnet sodium|
5823965|NCT00000725|Drug|Interferon alfa-2a|
5823966|NCT00000725|Drug|Zidovudine|
5823967|NCT00000725|Drug|Interferon alfa-n1|
5823968|NCT00000724|Drug|Trimetrexate glucuronate|
5823969|NCT00000724|Drug|Leucovorin calcium|
5823970|NCT00000723|Drug|Methotrexate|
5823971|NCT00000723|Drug|Leucovorin calcium|
5823972|NCT00000723|Drug|Zidovudine|
5823973|NCT00000723|Drug|Dexamethasone|
5823974|NCT00000722|Drug|Pentamidine isethionate|
5823975|NCT00000721|Drug|CD4 Antigens|
5823976|NCT00000720|Drug|Globulin, Immune|
5823977|NCT00000720|Drug|Zidovudine|
5823978|NCT00000719|Drug|Zidovudine|
5823979|NCT00000719|Drug|Zalcitabine|
5823980|NCT00000718|Drug|Zidovudine|
5823981|NCT00000718|Drug|Zalcitabine|
5823982|NCT00000717|Drug|Primaquine|
5823983|NCT00000717|Drug|Clindamycin|
5823984|NCT00000716|Drug|Zidovudine|
5823985|NCT00000715|Drug|Pentamidine isethionate|
5823986|NCT00000715|Drug|Sulfamethoxazole-Trimethoprim|
5823987|NCT00000714|Drug|Trimetrexate glucuronate|
5823988|NCT00000714|Drug|Leucovorin calcium|
5823989|NCT00000713|Drug|Ampligen|
5823990|NCT00000712|Drug|Zidovudine|
5823991|NCT00000712|Drug|Acyclovir|
5823992|NCT00000711|Drug|Zidovudine|
5823993|NCT00000711|Drug|Sargramostim|
5823994|NCT00000710|Drug|Didanosine|
5823995|NCT00000709|Drug|Zidovudine|
5823996|NCT00000708|Drug|Flucytosine|
5823997|NCT00000708|Drug|Fluconazole|
5823998|NCT00000708|Drug|Amphotericin B|
5823999|NCT00000707|Drug|Pentamidine isethionate|
5824000|NCT00000706|Drug|Quinine sulfate|
5824001|NCT00000706|Drug|Probenecid|
5824002|NCT00000706|Drug|Zidovudine|
5824003|NCT00000705|Drug|Zidovudine|
5824004|NCT00000704|Drug|Zalcitabine|
5824005|NCT00000703|Drug|Bleomycin sulfate|
5824006|NCT00000703|Drug|Vincristine sulfate|
5824007|NCT00000703|Drug|Doxorubicin hydrochloride|
5824008|NCT00000703|Drug|Cyclophosphamide|
5824009|NCT00000703|Drug|Allopurinol|
5824010|NCT00000703|Drug|Methotrexate|
5824011|NCT00000703|Drug|Cytarabine|
5824012|NCT00000703|Drug|Leucovorin calcium|
5824013|NCT00000703|Drug|Zidovudine|
5824014|NCT00000703|Drug|Dexamethasone|
5824015|NCT00000702|Drug|Zidovudine|
5824016|NCT00000701|Drug|Zidovudine|
5824017|NCT00000700|Drug|Zidovudine|
5824018|NCT00000699|Drug|Inosine pranobex|
5824019|NCT00000699|Drug|Ribavirin|
5824020|NCT00000698|Drug|Ganciclovir|
5824021|NCT00000697|Drug|Foscarnet sodium|
5824022|NCT00000696|Drug|Interferon alfa-2a|
5824023|NCT00000696|Drug|Zidovudine|
5824024|NCT00000695|Drug|Interferon beta-1b|
5824025|NCT00000695|Drug|Zidovudine|
5824026|NCT00000694|Drug|Interferon alfa-2b|
5824027|NCT00000694|Drug|Zidovudine|
5824028|NCT00000694|Drug|Sargramostim|
5824029|NCT00000693|Drug|Zidovudine|
5824030|NCT00000693|Drug|Acyclovir|
5824031|NCT00000692|Drug|Butyldeoxynojirimycin|
5824035|NCT00000689|Drug|Vincristine sulfate|
5824036|NCT00000689|Drug|Doxorubicin hydrochloride|
5824037|NCT00000689|Drug|Cyclophosphamide|
5824038|NCT00000689|Drug|Methotrexate|
5824039|NCT00000689|Drug|Cytarabine|
5824040|NCT00000689|Drug|Leucovorin calcium|
5824041|NCT00000689|Drug|Sargramostim|
5824042|NCT00000689|Drug|Dexamethasone|
5824043|NCT00000688|Drug|Ganciclovir|
5824044|NCT00000687|Drug|Interferon alfa-2a|
5824045|NCT00000687|Drug|Zidovudine|
5824046|NCT00000686|Drug|Stavudine|
5824047|NCT00000685|Drug|Zidovudine|
5824048|NCT00000684|Drug|Dextran sulfate|
5824049|NCT00000683|Biological|HIVAC-1e|
5824050|NCT00000683|Biological|gp160 Vaccine (MicroGeneSys)|
5824051|NCT00000682|Drug|Zidovudine|
5824052|NCT00000682|Drug|Zalcitabine|
5824053|NCT00000681|Drug|Bleomycin sulfate|
5824054|NCT00000681|Drug|Vincristine sulfate|
5824055|NCT00000681|Drug|Doxorubicin hydrochloride|
5824056|NCT00000681|Drug|Zidovudine|
5824057|NCT00000681|Drug|Sargramostim|
5824058|NCT00000680|Drug|Zidovudine|
5824059|NCT00000680|Drug|Aldesleukin|
5824060|NCT00000679|Drug|Zidovudine|
5824061|NCT00000679|Drug|Zalcitabine|
5824062|NCT00000678|Drug|Zidovudine|
5824063|NCT00000678|Drug|Zalcitabine|
5824064|NCT00000677|Drug|SCH 39304|
5824065|NCT00000676|Drug|Clotrimazole|
5824066|NCT00000676|Drug|Fluconazole|
5824067|NCT00000675|Drug|CD4-IgG|
5824068|NCT00000674|Drug|Pyrimethamine|
5824069|NCT00000674|Drug|Leucovorin calcium|
5824070|NCT00000674|Drug|Clindamycin|
5824071|NCT00000673|Drug|Ganciclovir|
5824072|NCT00000672|Drug|Didanosine|
5824073|NCT00000671|Drug|Zidovudine|
5824074|NCT00000671|Drug|Didanosine|
5824075|NCT00000670|Drug|Probenecid|
5824076|NCT00000670|Drug|Zidovudine|
5824077|NCT00000669|Drug|Didanosine|
5824078|NCT00000668|Drug|Ganciclovir|
5824079|NCT00000667|Biological|gp160 Vaccine (MicroGeneSys)|
5824080|NCT00000666|Drug|Pyrimethamine|
5824081|NCT00000665|Drug|Foscarnet sodium|
5824082|NCT00000665|Drug|Ganciclovir|
5824083|NCT00000664|Drug|Interleukin-2, Polyethylene Glycolated|
5824084|NCT00000664|Drug|Zidovudine|
5824085|NCT00000663|Drug|CD4-IgG|
5824086|NCT00000662|Drug|Zidovudine|
5824087|NCT00000661|Drug|Oxazepam|
5824088|NCT00000661|Drug|Zidovudine|
5824089|NCT00000660|Drug|Etoposide|
5824090|NCT00000659|Drug|CD4 Antigens|
5824091|NCT00000659|Drug|Zidovudine|
5824092|NCT00000658|Drug|Bleomycin sulfate|
5824093|NCT00000658|Drug|Vincristine sulfate|
5824094|NCT00000658|Drug|Doxorubicin hydrochloride|
5824095|NCT00000658|Drug|Cyclophosphamide|
5824096|NCT00000658|Drug|Allopurinol|
5824097|NCT00000658|Drug|Methotrexate|
5824098|NCT00000658|Drug|Cytarabine|
5824099|NCT00000658|Drug|Leucovorin calcium|
5824100|NCT00000658|Drug|Sargramostim|
5824101|NCT00000658|Drug|Dexamethasone|
5824102|NCT00000657|Drug|Zidovudine|
5824103|NCT00000657|Drug|Didanosine|
5824104|NCT00000656|Drug|Zidovudine|
5824105|NCT00000656|Drug|Didanosine|
5824106|NCT00000655|Drug|Atovaquone|
5824107|NCT00000655|Drug|Sulfamethoxazole-Trimethoprim|
5824108|NCT00000654|Drug|Fialuridine|
5824109|NCT00000653|Drug|Zalcitabine|
5824110|NCT00000652|Drug|Zidovudine|
5824111|NCT00000652|Drug|Didanosine|
5824112|NCT00000651|Drug|Zidovudine|
5824113|NCT00000651|Drug|Zalcitabine|
5824114|NCT00000650|Drug|Ditiocarb sodium|
5824115|NCT00000649|Drug|Nevirapine|
5824116|NCT00000649|Drug|Zidovudine|
5824117|NCT00000648|Drug|Penicillin G potassium|
5824118|NCT00000648|Drug|Ceftriaxone sodium|
5824119|NCT00000647|Drug|CD4-IgG|
5824120|NCT00000647|Drug|Zidovudine|
5824121|NCT00000647|Drug|Interferon alfa-n1|
5824122|NCT00000647|Procedure|Peripheral lymphocyte infusion|
5824123|NCT00000647|Procedure|Bone marrow transplant|
5824124|NCT00000646|Drug|Pentoxifylline|
5824125|NCT00000645|Drug|Hypericin|
5824126|NCT00000644|Drug|Clarithromycin|
5824127|NCT00000643|Drug|Pyrimethamine|
5824128|NCT00000643|Drug|Leucovorin calcium|
5824129|NCT00000642|Drug|CD4-IgG|
5824130|NCT00000641|Drug|Ciprofloxacin hydrochloride|
5824131|NCT00000641|Drug|Ethambutol hydrochloride|
5824132|NCT00000641|Drug|Amikacin sulfate|
5824133|NCT00000641|Drug|Azithromycin|
5824134|NCT00000641|Drug|Rifampin|
5824135|NCT00000641|Drug|Clofazimine|
5824136|NCT00000640|Drug|Primaquine|
5824137|NCT00000640|Drug|Sulfamethoxazole-Trimethoprim|
5824138|NCT00000640|Drug|Dapsone|
5824139|NCT00000640|Drug|Clindamycin|
5824140|NCT00000639|Drug|Itraconazole|
5824141|NCT00000639|Drug|Flucytosine|
5824142|NCT00000639|Drug|Fluconazole|
5824143|NCT00000639|Drug|Amphotericin B|
5824144|NCT00000638|Drug|Isoniazid|
5824145|NCT00000638|Drug|Pyrazinamide|
5824146|NCT00000638|Drug|Pyridoxine hydrochloride|
5824147|NCT00000638|Drug|Rifampin|
5824148|NCT00000637|Drug|Zidovudine|
5824149|NCT00000637|Drug|Didanosine|
5824150|NCT00000636|Drug|Isoniazid|
5824151|NCT00000636|Drug|Pyrazinamide|
5824152|NCT00000636|Drug|Pyridoxine hydrochloride|
5824153|NCT00000636|Drug|Rifampin|
5824154|NCT00000635|Drug|Trifluridine|
5824155|NCT00000635|Drug|Bacitracin zinc/Polymyxin B sulfate|
5824156|NCT00000634|Drug|Nevirapine|
5824157|NCT00000633|Biological|gp160 Vaccine (Immuno-AG)|
5824158|NCT00000633|Biological|Hepatitis B Vaccine (Recombinant)|
5824159|NCT00000632|Biological|Env 2-3|
5824160|NCT00000631|Biological|HIVAC-1e|
5824161|NCT00000631|Biological|gp160 Vaccine (MicroGeneSys)|
5824162|NCT00000630|Biological|HIVAC-1e|
5824163|NCT00000630|Biological|gp160 Vaccine (MicroGeneSys)|
5824164|NCT00000629|Drug|Valproic acid|
5824165|NCT00000629|Drug|Zidovudine|
5824166|NCT00000628|Drug|L-697,661|
5824167|NCT00000628|Drug|Zidovudine|
5824168|NCT00000627|Drug|Fluconazole|
5824169|NCT00000626|Drug|Vinblastine sulfate|
5824170|NCT00000626|Drug|Dacarbazine|
5824171|NCT00000626|Drug|Filgrastim|
5824172|NCT00000626|Drug|Bleomycin sulfate|
5824173|NCT00000626|Drug|Doxorubicin hydrochloride|
5824174|NCT00000625|Drug|Zidovudine|
5824175|NCT00000625|Drug|Zalcitabine|
5824176|NCT00000625|Drug|Didanosine|
5824177|NCT00023192|Drug|T-Cell Depleted & CD34+Select/w/StemCell Enriched Product|
5824178|NCT00023166|Drug|PEG-paclitaxel|
5824179|NCT00023153|Drug|Adefovir Dipivoxil|
5824180|NCT00023127|Procedure|Integrated Pest Management|
5824181|NCT00022971|Biological|Apolizumab|Apolizumab IV on Day 1. Administer weekly for 4 weeks
5824182|NCT00022971|Biological|Rituximab|Rituximab IV 24-36 hours after Apolizumab ends. Administer weekly for 4 weeks
5824183|NCT00022958|Drug|Iodine-131 Anti-B1 Antibody|
5824184|NCT00022945|Drug|Iodine-131 Anti-B1 Antibody|
5824185|NCT00022945|Drug|Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP)|
5824186|NCT00022932|Drug|Iodine-131 Anti-B1 Antibody|
5824187|NCT00022906|Drug|Iodine-131 Anti-B1 Antibody|
5824188|NCT00022893|Drug|Iodine-131 Anti-B1 Antibody|
5824189|NCT00022880|Drug|Iodine-131 Anti-B1 Antibody|
5824190|NCT00022867|Drug|Nondigestible oligosaccharide (NDO)|
5824191|NCT00022854|Procedure|Single-injection femoral nerve block|Nerve block bolus with 30 mL levobupivacaine 0.25%, followed by continuous saline infusion
5824192|NCT00022854|Procedure|Femoral nerve block 60-hour continuous injection|Nerve block bolus with 30 mL levobupivacaine 0.25%, followed by continuous infusion (5 mL/hr for 50 hours) of 0.25% levobupivacaine
5824193|NCT00022854|Procedure|Saline (control) injection into femoral nerve envelope|Nerve block bolus with 30 mL saline, followed by continuous saline infusion
5824194|NCT00022841|Drug|Pamidronate|
5824195|NCT00022828|Device|3-D Laser Imaging Device|
5824196|NCT00022815|Device|Tissue ultrafiltration|
5824197|NCT00022802|Device|Image-guided surgical system|
5824198|NCT00022776|Procedure|Surgical decompression|Simple decompression not requiring fusion.
5824199|NCT00022776|Procedure|Physical therapy|2 physical therapy sessions per week for 6 weeks Followed by home program.
5824200|NCT00022750|Behavioral|Nurse Case Manager and Community Health Worker Team|
5824201|NCT00021866|Behavioral|Differential Abilities Scale|IQ measurement at 3, 4.5 and 6 years of age
5824202|NCT00021866|Behavioral|Neuropsychological Testing|Tests of memory, attention, and behavior administered at 2,3, 4.5 and 6 Years of age
5824203|NCT00021853|Behavioral|constraint-induced movement therapy|
5824204|NCT00021827|Drug|Parathyroid hormone-related protein or ''PTHrP''|
5824205|NCT00021814|Drug|Doxazosin|
5824206|NCT00021814|Drug|Finasteride|
5824207|NCT00021814|Drug|Doxazosin placebo|
5824208|NCT00021814|Drug|Finasteride placebo|
5824209|NCT00021801|Procedure|Islet Cell Transplantation|
5824210|NCT00021788|Procedure|islet cell transplantation|
5824211|NCT00021749|Drug|Oblimerson sodium, G3139|
5824212|NCT00021736|Drug|EYE001 anti-VEGF aptamer|
5824213|NCT00021723|Biological|AN-1792 also known as AIP-001|
5824214|NCT00021697|Drug|AVP-923|
5824215|NCT00021658|Procedure|Pesticide application procedures|
5824216|NCT00021645|Drug|Vitamin E|
5824217|NCT00021580|Procedure|human cadaveric islet cell transplantation|
5824218|NCT00021567|Drug|Interferon Gamma for Aerosol|
5824219|NCT00021541|Drug|tipifarnib|Given orally, 200 mg/m^2/dose BSA every 12 hours by mouth (po) daily x 21 days, Course is every 28 days
5824220|NCT00021541|Other|placebo|Patients receive oral placebo every 12 hours on days 1-21. Courses repeat as in arm I.
5824221|NCT00021528|Drug|citalopram|
5824222|NCT00021528|Drug|BuproprionSR|
5824223|NCT00021528|Drug|buspirone|
5824224|NCT00021528|Drug|Lithium|
5824225|NCT00021528|Drug|mirtazapine|
5824226|NCT00021528|Drug|nortriptyline|
5824227|NCT00021528|Drug|sertraline|
5824228|NCT00021528|Drug|tranylcypromine|
5824229|NCT00021528|Drug|VenlafaxineXR|
5824230|NCT00021528|Behavioral|Cognitive Therapy|
5824231|NCT00021528|Drug|T3 (Triiodothyronine)|
5824232|NCT00021502|Drug|pyridoxalated hemoglobin polyoxyethylene conjugate (PHP)|
5824233|NCT00021476|Behavioral|Behavioral treatments|
5824234|NCT00021476|Behavioral|Physical therapy|
5824235|NCT00018902|Drug|Fluoxetine|Standard anti-depressant treatment with the SSRI fluoxetine
5824236|NCT00018902|Drug|Venlafaxine|Standard antidepressant treatment with the non-SSRI medication venlafaxine
5824237|NCT00018902|Behavioral|Cognitive Behavioral Therapy (CBT)|CBT addresses maladaptive beliefs in order to encourage behavioral change
5824238|NCT00018902|Drug|Citalopram|Standard anti-depressant treatment with the SSRI fluoxetine
5824239|NCT00018876|Procedure|Lumbar nerve root decompression|
5824240|NCT00018876|Procedure|Preoperative low-dose external beam radiation|
5824241|NCT00018863|Drug|Methylphenidate|
5824242|NCT00018850|Drug|ondansetron|
5824243|NCT00018850|Behavioral|neuropsychological testing|
5824244|NCT00018850|Drug|nicotine|
5824245|NCT00018850|Drug|haloperidol|
5824246|NCT00018837|Behavioral|Community Re-Entry Program: What is Schizophrenia|
5824247|NCT00018824|Drug|NALTREXONE|
5824249|NCT00018811|Behavioral|Relaxation training & thermal biofeedback|
5824250|NCT00018811|Behavioral|Surface EMG biofeedback|
5824251|NCT00018785|Procedure|donor bone marrow infusion|
5824252|NCT00018759|Drug|paroxetine|
5824253|NCT00018759|Behavioral|ongoing psychological screening|
5824254|NCT00018746|Device|repetitive transcranial magnetic stimulation|
5824255|NCT00018733|Drug|paroxetine|
5824256|NCT00018733|Drug|Desipramine|
5824257|NCT00018694|Drug|Chenodeoxycholic Acid|
5824258|NCT00018668|Drug|Risperidone|
5824259|NCT00018668|Drug|Olanzapine|
5824260|NCT00018668|Drug|Quetiapine|
5824261|NCT00018655|Behavioral|Twelve Step Facilitation|Twelve Step Facilitation Therapy involves focusing on topics from 12-Step programs which support sobriety goals and personal growth.
5824262|NCT00018655|Behavioral|Integrated Cognitive Behavioral Treatment|Integrated Cognitive Behavioral Treatment involves focusing on thoughts, activities, and interactions with people related to depressive symptoms and/or substance use.
5824263|NCT00018642|Drug|quetiapine|
5824264|NCT00018642|Drug|haloperidol decanoate|
5824265|NCT00018616|Behavioral|MEMS caps|
5824266|NCT00018603|Drug|guanfacine|
5824267|NCT00018564|Drug|treatments for essential tremor|
5824268|NCT00018551|Drug|Folic Acid|
5824269|NCT00018538|Drug|calcifidiol|
5824270|NCT00018525|Procedure|Lung Volume Reduction Surgery|
5824271|NCT00018512|Procedure|Implant-supported denture|
5824272|NCT00018460|Drug|Vitamin B|
5824273|NCT00018447|Drug|PTH 1-34|
5824274|NCT00018447|Drug|MFPSR-fluoride|
5824275|NCT00018421|Procedure|Treadmill Exercise|
5824276|NCT00018382|Drug|rosiglitazone|
5824277|NCT00018356|Procedure|exercise|
5824278|NCT00018356|Drug|testosterone|
5824279|NCT00018343|Drug|estrogen|
5824280|NCT00018330|Behavioral|Weight Loss|
5824281|NCT00018317|Behavioral|low protein diet|
5824282|NCT00018317|Behavioral|resistance training|
5824283|NCT00018317|Behavioral|combination of diet control and exercise|
5824284|NCT00018291|Drug|Risperidone|
5824285|NCT00018291|Drug|Gabapentin|
5824286|NCT00018278|Drug|Aricept|
5824287|NCT00018278|Drug|Exelon|
5824288|NCT00018278|Drug|Nicoderm Patch|
5824289|NCT00018265|Behavioral|Task specific endurance training|
5824290|NCT00018265|Behavioral|Tai Chi|
5824291|NCT00018252|Behavioral|exercise|
5824292|NCT00018239|Procedure|Exercise|
5824293|NCT00018226|Behavioral|Case Management|
5824294|NCT00018213|Drug|Naltrexone Hydrochloride|
5824295|NCT00018213|Drug|Transdermal Nicotine|
5824296|NCT00018200|Drug|Desipramine|Low exposure (40-70 ng/mL), Middle exposure (70-130 ng/mL), High exposure (130-200 ng/mL)
5824297|NCT00018200|Drug|Fluoxetine|Low exposure (200-399 ng/mL), Middle exposure (400-499 ng/mL), High exposure (500-700ng/mL)
5824298|NCT00018200|Drug|Benztropine|Daily dose 0.125 to 0.5mg
5824299|NCT00018187|Drug|Bupropion|
5824300|NCT00018187|Drug|Mecamylamine|
5824301|NCT00018187|Drug|Nicotine Patch|
5824302|NCT00018174|Drug|Fluoxetine|
5824303|NCT00018174|Behavioral|Behavioral group smoking cessation treatment|
5824304|NCT00018174|Drug|Placebo|
5824305|NCT00018161|Drug|Mecamylamine|
5824306|NCT00018161|Drug|Nicotine Patch|
5824307|NCT00018161|Behavioral|Cigarette brand switching|
5824308|NCT00018148|Drug|nortriptyline|Dose titrated to 75 mg daily as tolerated combined with transdermal nicotine 21 mg
5824309|NCT00018148|Drug|transdermal nicotine|Transdermal nicotine 21 mg, titrated down plus placebo
5824310|NCT00018135|Drug|calcium acetate|
5824311|NCT00018135|Drug|aluminum hydroxide|
5824312|NCT00018135|Drug|Sevelamer|
5824313|NCT00018109|Drug|glutamine|
5824314|NCT00018109|Drug|creatine monohydrate|
5824315|NCT00018096|Biological|LPS endotoxin, saline, HDM|instillation of interventional products during bronchoscopy each down a different airway, each subject acts as their own control.
5824316|NCT00018083|Drug|rifabutin|
5824317|NCT00018083|Drug|isoniazid|
5824318|NCT00018083|Drug|efavirenz|
5824319|NCT00018070|Procedure|Angiography|
5824320|NCT00018070|Procedure|Laser Treatment|
5824321|NCT00018057|Behavioral|Attention Bias Modification Training|The intervention is computer-based. The active and control treatments have two components. In one component of the active intervention, subjects are asked to indicate the identity of a letter that appears behind a neutral face, opposite from an angry face. In another component of the active intervention, subjects are asked to identify numbers that are hidden within a puzzle, in locations distal from angry faces. In both components of the active intervention, subjects implicitly learn to shift their attention away from angry faces. This is because the faces are systematically arranged to be far removed from letters and numbers that need to be identified. The control arm of the intervention involves similar components. However, unlike in the intervention arm, angry faces appear in various locations near letters and numbers. Therefore, attention is not shaped in the control arm. This intervention requires five minutes per session and is administered before weekly psychotherapy sessions.
5824322|NCT00018031|Drug|Peginterferon alfa-2b|Weekly injections for 48 weeks of a dose of 1.5mcg/Kg per week subcutaneously
5824323|NCT00018031|Drug|Ribavirin|Weight based Ribavirin dosing 1-1.2grams/day in divided (twice daily) doses for a total duration of 48 weeks.
5824324|NCT00018018|Drug|CD34+ cells transduced with ADA retrovir|
5824325|NCT00018005|Behavioral|Self-Management|18 in-person group sessions providing self-management training.
5824326|NCT00018005|Other|attention control|18 educational mailings follow by a a telephone call.
5824327|NCT00017940|Genetic|Human Nerve Growth Factor|
5824415|NCT00014755|Drug|prednisone|
5824416|NCT00014755|Procedure|peripheral blood stem cell transplantation|
5824417|NCT00014755|Procedure|irradiation|
5824418|NCT00014742|Drug|collagenase|
5824419|NCT00014729|Drug|isotretinoin|
5824328|NCT00017953|Behavioral|Lifestyle Intervention|The lifestyle intervention is implemented with individual supervision and group sessions and is aimed at achieving and maintaining at least a 7% decrease in weight from baseline and 175 minutes per week in physical activity. It is implemented during a four-year period with the most intensive application during the first year, less frequent attention during the next three years, and a minimum of twice yearly contacts during an extended follow-up period. To help participants achieve and maintain weight loss, a variety of diet strategies (e.g. prepared meals and liquid formula), exercise strategies, and optional weight loss medications are utilized based on a preset algorithm and participant progress.
5824329|NCT00017953|Behavioral|Diabetes Support and Education|Participants assigned to diabetes support and education are offered three sessions each year in diabetes management and social support.
5824330|NCT00017927|Drug|Pegvisomant|
5824331|NCT00017823|Procedure|Acupressure|
5824332|NCT00017810|Behavioral|Dietary intervention|
5824333|NCT00017706|Behavioral|physician-delivered weight control|
5824334|NCT00016835|Procedure|Supra-gingival scaling and placebo|Included in arm/group description.
5824335|NCT00016835|Procedure|Subgingival scaling and metronidazole|Included in arm/group description.
5824336|NCT00016835|Procedure|Subgingival scaling and doxycycline|Included in arm/group description.
5824337|NCT00017680|Drug|Melphalan|100 mg/m2 twice a day from Days -2 and -1 as induction therapy
5824338|NCT00017680|Procedure|Autologous Stem Cell Transplantation|Bone marrow and peripheral blood stem cells harvested
5824339|NCT00017654|Drug|anti-thymocyte globulin|
5824340|NCT00017654|Drug|cyclophosphamide|
5824341|NCT00017654|Drug|cyclosporine|
5824342|NCT00017654|Drug|methylprednisolone|
5824343|NCT00017654|Procedure|Allogeneic Bone Marrow Transplantation|
5824344|NCT00017641|Drug|anti-thymocyte globulin|
5824345|NCT00017641|Drug|cyclophosphamide|
5824346|NCT00017641|Drug|filgrastim|
5824347|NCT00017641|Procedure|CD34+ Peripheral Blood Stem Cell Reinfusion|
5824348|NCT00017628|Drug|cyclophosphamide|
5824349|NCT00017628|Drug|filgrastim|
5824350|NCT00017628|Drug|methylprednisolone|
5824351|NCT00017628|Procedure|Autologous Stem Cell Transplantation|
5824352|NCT00016744|Drug|Sodium 4-Phenylbutyrate (4PBA)|The standard oral adult dose is 20g/day (tablets) for 4 days.
5824353|NCT00016744|Drug|Unconjugated Isoflavones 100 (PTI G-4660, 87% Genistein)|Every participant will be administered a perfusion of 50 MicroM of Genistein during the modified NPD procedure.
5824354|NCT00016744|Drug|Placebo|The placebo dose will match the oral tablets in arm 1, maintaining the study blind.
5824355|NCT00016679|Drug|1-Octanol|
5824356|NCT00016666|Drug|Propranolol|
5824357|NCT00016653|Drug|Creatine Monohydrate|
5824358|NCT00016653|Drug|Glutamine|
5824359|NCT00016549|Biological|Bevacizumab|
5824360|NCT00016523|Drug|Inhaled nitric oxide|Started at 5 ppm and could be increased to 10 ppm
5824361|NCT00016523|Drug|Placebo|Started at 5 ppm and could be increased to 10 ppm
5824362|NCT00016497|Procedure|bilateral myringotomy|
5824363|NCT00016497|Procedure|bilateral myringotomy and tubes|
5824364|NCT00016497|Procedure|adenoidectomy|
5824365|NCT00016471|Procedure|Audiogram|
5824366|NCT00016471|Procedure|Electroretinogram|
5824367|NCT00016458|Drug|anti-thymocyte globulin|
5824368|NCT00016458|Drug|cyclophosphamide|
5824369|NCT00016445|Drug|growth hormone|
5824370|NCT00015808|Drug|Idebenone|
5824371|NCT00015795|Device|airway interruption test|
5824372|NCT00015769|Drug|levetiracetam|
5824373|NCT00015665|Drug|Voriconazole|
5824374|NCT00015626|Drug|Metformin|
5824375|NCT00015626|Procedure|skin biopsy|
5824376|NCT00015626|Behavioral|diet and exercise|
5824377|NCT00015626|Drug|pioglitazone|
5824378|NCT00015626|Drug|rosiglitazone|
5824379|NCT00015600|Behavioral|Behavior modification through social marketing|
5824380|NCT00015548|Drug|Olanzapine|
5824381|NCT00015548|Drug|Quetiapine|
5824382|NCT00015548|Drug|Risperidone|
5824383|NCT00015548|Drug|Citalopram|
5824384|NCT00015457|Drug|Amlodipine plus Botulinum toxin|
5824385|NCT00015015|Drug|Dichloroacetate|
5824386|NCT00015340|Drug|Buprenorphine/naloxone|
5824387|NCT00015301|Drug|Methylphenidate|
5824388|NCT00015288|Drug|Buprenorphine/naloxone|
5824389|NCT00015275|Behavioral|Cocaine-Related Disorders|
5824390|NCT00015249|Drug|Amantadine|
5824391|NCT00015236|Behavioral|Amantadine|
5824392|NCT00015223|Drug|Methylphenidate|
5824393|NCT00015210|Drug|Nefazodone|
5824394|NCT00015210|Behavioral|Psychosocial Treatment|All subjects attended a weekly 1-hour therapy session during the 8 week treatment period.
5824395|NCT00015171|Drug|Buprenorphine/naloxone|
5824396|NCT00015132|Drug|Sertraline|
5824397|NCT00015106|Drug|Lamotrigine|
5824398|NCT00015080|Drug|Naltrexone|
5824399|NCT00015067|Drug|Methylphenidate|
5824400|NCT00015054|Drug|Methylphenidate|
5824401|NCT00015041|Drug|Buprenorphine|
5824402|NCT00015028|Drug|Buprenorphine/naloxone|
5824403|NCT00015002|Drug|Betamethasone|"coded study medication is 12 mg of betamethasone (or placebo) given as 2 ml intramuscular injection in 2 doses, 24 hours apart (the Course). Patients administered weekly courses for 4 weeks, until 33 weeks 6 days gestation or delivery, whichever occurs first."
5824404|NCT00014989|Drug|magnesium sulfate|
5824405|NCT00014950|Procedure|CF newborn screening|
5824406|NCT00014833|Other|No intervention|No intervention
5824407|NCT00014807|Behavioral|Reducing Pesticide Exposure in Minority Families|
5824408|NCT00014794|Drug|15-O labeled water|
5824409|NCT00014768|Drug|glucose|
5824410|NCT00014768|Drug|insulin|
5824411|NCT00014768|Drug|leucine|
5824412|NCT00014755|Drug|anti-thymocyte globulin|
5824413|NCT00014755|Drug|cyclophosphamide|
5824414|NCT00014755|Drug|filgrastim|
5824420|NCT00014040|Drug|Nitric Oxide and INOpulse Delivery System|
5824421|NCT00014027|Drug|Docosahexaenoic acid (DHA)|
5824422|NCT00014027|Drug|Eicosapentaenoic acid|
5824423|NCT00014001|Drug|perphenazine|
5824424|NCT00014001|Drug|olanzapine|
5824425|NCT00014001|Drug|quetiapine|
5824426|NCT00014001|Drug|risperidone|
5824427|NCT00014001|Drug|ziprasidone|
5824428|NCT00014001|Drug|clozapine|
5824429|NCT00014001|Drug|fluphenazine decanoate|
5824430|NCT00013962|Drug|Vitamin D|
5824431|NCT00013923|Drug|Nutritional Supplement|
5824432|NCT00013910|Drug|NNC 90-1170|
5824433|NCT00013884|Drug|T-20|
5824434|NCT00013806|Drug|131I-MIBG|
5824435|NCT00013793|Behavioral|Motivational enhancement and ultrasound|
5824436|NCT00013767|Behavioral|Individual and Community education|
5824437|NCT00013741|Behavioral|Tailored Education Messages|
5824438|NCT00013702|Drug|Adefovir|
5824439|NCT00013689|Drug|Fansidar (pyrimethamine and sulfadoxine)|
5824440|NCT00013650|Drug|Cyclophosphamate|
5824441|NCT00013624|Drug|IV Levodopa|
5824442|NCT00013611|Drug|Proleukin|Recombinant IL-2 was given at a dose of 4.5 MIU twice daily subcutaneously for 5 consecutive days every 8 weeks, in addition to antiretroviral therapy, for 6 cycles. After the first 6 cycles, additional cycles were given to either achieve or maintain the patient's CD4+ cell count goal.
5824443|NCT00013598|Drug|Pioglitazone|
5824444|NCT00013546|Drug|TMTDS|
5824445|NCT00013533|Procedure|Stem cell transplantation|>3 x 106/kg CD34+ stem cells by IV infusion
5824446|NCT00013507|Procedure|Falls|
5824447|NCT00013494|Procedure|Stroke Rehabilitation|
5824448|NCT00013481|Procedure|Stroke Rehabilitation|
5824449|NCT00013468|Procedure|Tinnitus|
5824450|NCT00013455|Device|Hearing|
5824451|NCT00013442|Procedure|Auditory Evoked Response|
5824452|NCT00013429|Procedure|Visual|
5824453|NCT00013416|Procedure|Hearing|
5824454|NCT00013403|Procedure|Blindness|
5824455|NCT00013390|Procedure|Tinnitus Masking|"Tinnitus Masking is a widely-used method for providing relief of tinnitus. The central premise of Tinnitus Masking involves the use of wearable ear-level devices (hearing aids, maskers, or combination instruments) that deliver sound to a patient's ear(s). The primary purpose of the sound presentation is to produce a sense of relief from the annoyance caused by the tinnitus sound. The relief is accomplished by either obscuring, or covering up (masking) the tinnitus sound, or by changing the sound of the tinnitus in some way, usually by reducing its loudness (Vernon, Meikle)."
5824456|NCT00013390|Procedure|Tinnitus Retraining Therapy|"Tinnitus Retraining Therapy (TRT) was derived from a purely psychological approach for facilitating tinnitus habituation (Hallam et al). The current method is based on neurophysiological principles, and aims at retraining brain regions that are involved in processing the tinnitus signal, without attempting to suppress generation of the signal (Jastreboff). The retraining involves a systematic effort aimed at decreasing both the detectability of tinnitus and the transmission of the tinnitus signal to emotional centers of the brain. Habituation of tinnitus thus purportedly occurs at two levels: habituation of emotional reactions to the tinnitus and habituation of tinnitus perception. Habituation is achieved by utilizing directive counseling, along with the use of low-level broadband noise to reduce the detectability of tinnitus for patients with normal or near-normal hearing. When hearing loss is a significant problem to the patient, appropriate hearing aids are fitted."
5824457|NCT00013377|Procedure|Low vision|
5824458|NCT00013364|Behavioral|Talker variability|
5824459|NCT00013351|Procedure|Prevention of Falls|
5824460|NCT00013338|Procedure|Ambulation Training|
5824461|NCT00013325|Procedure|Cardiac Disease|
5824462|NCT00013312|Procedure|Determine colonic tone|
5824463|NCT00013299|Device|Prevention of Diabetic Ulcers|
5824464|NCT00013286|Device|Prevention Diabetic Foot Ulcer|
5824465|NCT00013273|Procedure|Physical Conditioning|
5824466|NCT00013260|Procedure|Integrated model of primary care|
5824467|NCT00013247|Behavioral|Prostate Cancer Screening Education|
5824468|NCT00013234|Procedure|Teledermatology|
5824469|NCT00013221|Behavioral|Exercise|
5824470|NCT00013208|Behavioral|Case Management|
5824471|NCT00013195|Behavioral|Telephone Care|
5824472|NCT00013182|Behavioral|social activity|
5824473|NCT00013169|Behavioral|Strong Patient Focus|
5824474|NCT00013156|Procedure|Effectiveness of Lung Reduction Therapy|
5824475|NCT00013143|Behavioral|Patient risk profiling (potential ADEs) w/provider feedback|
5824476|NCT00013130|Behavioral|Provision of health status information to patients provider|
5824477|NCT00013117|Behavioral|Telephone specialist consultation|
5824478|NCT00013091|Behavioral|Self-management therapy; Psychoeducational group therapy|
5824479|NCT00013078|Procedure|Physical restoration intervention|
5824480|NCT00013052|Behavioral|Peer led classes. Led by trained veterans with a chronic disease.|
5824481|NCT00013039|Behavioral|Computer reminders|
5824482|NCT00013026|Behavioral|CHF Self-management Education (Web-based Education)|
5824483|NCT00013013|Procedure|Systems Support|
5824484|NCT00013000|Behavioral|Test strategy for implementation guideline|
5824485|NCT00012987|Behavioral|Quality Improvement|
5824486|NCT00012974|Behavioral|GTelephone-administered Cognitive-Behavioral Therapy (T-CBT)|
5824487|NCT00012974|Procedure|Provider education, computer reminders, nurse case management|
5824488|NCT00012948|Procedure|Telephone Care|
5824489|NCT00012935|Behavioral|Help with decision making on prostate cancer treatment|
5824490|NCT00012922|Behavioral|Low Literacy Intervention for Colorectal Cancer Screening|
5824491|NCT00012909|Behavioral|Hormone Replacement Therapy Decision-Aid|
5824492|NCT00012896|Behavioral|Telephone Care + Educational (AV Materials)|
5824493|NCT00012883|Behavioral|Homewalking exercise program|
5824494|NCT00012870|Behavioral|Behavioral Management|
5824495|NCT00012857|Drug|acetaminophen 650 mg qid and placebo qid PRN. The other arm was placebo qid and acetaminophen 650 mg qid PRN|
5824496|NCT00012844|Device|Redesigning patient handling tasks using equip: Arjo Bianca Overhead Lift, Hill-Rom Resident Transfer Device, TranSit Chair, Total Care Bed|
5824497|NCT00012844|Procedure|Redesigned patient handling tasks using work practice controls: setting bed height at correct level; applying anti-embolism stockings from foot of bed|
5824498|NCT00012818|Behavioral|relaxation technique|
5824499|NCT00012818|Behavioral|educational program|
5824500|NCT00012805|Procedure|Telephone Monitoring|
5824501|NCT00012792|Behavioral|Exercise Training|
5824502|NCT00012779|Behavioral|Health Education Program|
5824503|NCT00012766|Behavioral|Integrated team care|
5824504|NCT00012753|Procedure|Automated telephone health status assessments with nurse follow-up.|
5824505|NCT00012740|Behavioral|Casefinding and Referral System|
5824506|NCT00012727|Procedure|Matching Symptom Severity to Service Intensity|
5824507|NCT00012714|Behavioral|Case management services|
5824508|NCT00012688|Drug|Doxycycline HCI 10mg po for 2 weeks|
5824509|NCT00012688|Procedure|Ultrasonic scaling with 0.12% chlorhexidine gluconate|
5824510|NCT00012662|Behavioral|Diabetes Self Management Education|
5824511|NCT00012636|Procedure|Computer generated statements about guideline concordance of drug therapy deliver to clinicians|
5824512|NCT00012610|Procedure|Telepsychiatry|
5824513|NCT00012597|Procedure|Web-based telemedicine system for assessment of status of pressure ulcers|
5824514|NCT00012584|Drug|methylphenidate|
5824515|NCT00012584|Drug|fluvoxamine|
5824516|NCT00012558|Drug|lithium|
5824517|NCT00012558|Drug|valproate|
5824518|NCT00012558|Drug|bupropion|
5824519|NCT00012558|Drug|paroxetine|
5824520|NCT00012558|Drug|lamotrigine|
5824521|NCT00012558|Drug|risperidone|
5824522|NCT00012558|Drug|inositol|
5824523|NCT00012558|Drug|tranylcypromine|
5824524|NCT00012558|Behavioral|Cognitive Behavioral Therapy|
5824525|NCT00012558|Behavioral|Family-focused Therapy|
5824526|NCT00012558|Behavioral|Interpersonal and Social Rhythms Therapy|
5824527|NCT00012506|Drug|TNFR:Fc|
5824528|NCT00012441|Procedure|hemodialysis|
5824529|NCT00011908|Drug|hLL2 (Epratuzumab)|
5824530|NCT00011830|Drug|G-CSF|
5824531|NCT00011830|Procedure|Apheresis|
5824532|NCT00011804|Drug|Topiramate|
5824533|NCT00011778|Drug|bortezomib|
5824534|NCT00011778|Radiation|radiation therapy|
5824535|NCT00011765|Drug|Fluoxetine|
5824536|NCT00011752|Drug|FCWAY|
5824537|NCT00011713|Other|Completion questionnaires/providing biological samples|Participant completes baseline interview at enrollment, then completes online questionnaire on lifestyle and medical history. Diet questionnaire is completed at home and mailed back. Online questionnaire about personal care product use and medications is completed at each scheduled study visit.
5824538|NCT00011661|Behavioral|Education on behaviors to reduce lead exposure|
5824539|NCT00011622|Device|Continuous ambulatory subcutaneous glucose monitor|
5824540|NCT00011609|Device|Robotic Arm|
5824541|NCT00011596|Procedure|Gait Training|
5824542|NCT00011583|Device|Robot-assisted therapy|1 hour/day of mechanically-assisted upper limb therapy
5824543|NCT00011583|Device|Traditional therapy|1 hour/day of upper limb therapy that includes exposure to, but no manipulation by the robot
5824544|NCT00011570|Device|Bladder & Bowel Control|
5824545|NCT00011557|Device|Assistance in Voiding|
5824546|NCT00011544|Procedure|Performance Measure|
5824547|NCT00011531|Procedure|Prevention of Pressure Ulcers|
5824548|NCT00011505|Drug|G-CSF|
5824549|NCT00011505|Procedure|Leukapheresis|
5824550|NCT00011414|Drug|Tariquidar|IV alone for 1 dose (Day -1), then in combo for rest of cycle (Day 1, etc). Given in combo with one of the following: Doxorubicin (50 mg/m2 IV over 15 min on day 1), Vinorelbine (20 mg/m2 IV over 10 min on days 1 and 8), or Docetaxel (75 mg/m2 IV over 60 min on day 1).
5824551|NCT00011375|Drug|Rolipram|
5824552|NCT00011362|Drug|Dexamethasone Early|Tapering course of dexamethasone in doses given twice a day (0.25 mg per kilogram of body weight per dose for five days, then 0.15 mg, 0.07 mg, and 0.03 mg per kilogram per dose for three days each), followed by two weeks of saline.
5824553|NCT00011362|Drug|Dexamethasone Late|Saline for two weeks, followed by either the same tapering two-week course of dexamethasone given to the first group, if the respiratory-index score was >=2.4 on treatment day 14, or an additional two weeks of saline
5824554|NCT00011297|Drug|gabapentin (Neurontin)|
5824555|NCT00011297|Drug|lorazepam (Ativan)|
5824556|NCT00011258|Drug|Paraoxonase|
5824557|NCT00011141|Drug|Oral lactobacillus administration|
5824558|NCT00011193|Behavioral|Exercise|Compared the effect of 50%, 100%, and 150% of the NIH Consensus Development Panel recommended physical activity dose on fitness in women.
5824559|NCT00011076|Drug|Pirfenidone|
5824560|NCT00011115|Behavioral|Weight loss motivations|
5824561|NCT00011102|Behavioral|Weight Gain Prevention for Women Project|
5824562|NCT00011024|Procedure|Self Hypnosis|
5824563|NCT00011024|Procedure|Acupuncture|
5824564|NCT00011024|Procedure|Osteopathic Manipulation|
5824565|NCT00010998|Procedure|Yoga|
5824566|NCT00010985|Procedure|Acupuncture|
5824567|NCT00010985|Procedure|Chiropractic|
5824568|NCT00010985|Procedure|massage|
5824569|NCT00010972|Procedure|Acupuncture|
5824570|NCT00010959|Drug|Cimicifuga racemosa|
5824571|NCT00010959|Drug|Trifolium pratense|
5824572|NCT00010946|Procedure|Acupuncture|
5824573|NCT00010933|Drug|chamomile tea|
5824574|NCT00010933|Procedure|Relaxation/Guided Imagery|
5824575|NCT00010920|Drug|Ginkgo Biloba Extract|
5824576|NCT00010907|Drug|NPI-028|
5824577|NCT00010881|Drug|antioxidants|
5824578|NCT00010881|Behavioral|stress reduction|
5824579|NCT00010868|Drug|Omega-3 Fatty Acids|
5824580|NCT00010855|Behavioral|Self-hypnotic relaxation|
5824581|NCT00010842|Drug|Ginkgo biloba|
5824584|NCT00010842|Drug|Essential fatty acids|
5824585|NCT00010829|Behavioral|American Heart Association Step 1 diet|
5824586|NCT00010829|Behavioral|American Heart Association Step 2 diet + 10 g/day flax seed|
5824587|NCT00010829|Behavioral|Macrobiotic dietary intervention|
5824588|NCT00010816|Drug|Herbal remedies|
5824589|NCT00010803|Drug|Ginkgo biloba|120mg twice a day
5824590|NCT00010803|Drug|Placebo|One pill twice daily
5824591|NCT00010777|Procedure|Multiple Component Mind/Body therapy|
5824592|NCT00010764|Procedure|Acupuncture|
5824593|NCT00010751|Procedure|Reiki|
5824594|NCT00010738|Procedure|Meditation|
5824595|NCT00010725|Drug|MAK|
5824596|NCT00010725|Drug|Vitamin Supplements|
5824597|NCT00010712|Drug|Black Cohosh|
5824598|NCT00010699|Drug|Vitamin E|
5824599|NCT00010686|Drug|Dietary Phytoestrogens|
5824600|NCT00010634|Drug|Connective Tissue Nutrient Formula|
5824601|NCT00010634|Drug|Adaptogenic herbs|
5824602|NCT00010634|Drug|glutamine|
5824603|NCT00010621|Procedure|Acupuncture|
5824604|NCT00010621|Procedure|chiropractic therapy|
5824605|NCT00010621|Procedure|bodywork therapy|
5824606|NCT00010608|Behavioral|Transcendental Meditation|a mantra meditation technique which originated from the Vedic tradition of India. It is practiced from 20 minutes twice a day sitting comfortably in a chair with eyes closed.
5824607|NCT00010608|Behavioral|Health Education|didactic education classes for lifestyle modification through diet, exercise, substance use control, and salt intake
5824608|NCT00010530|Procedure|Meditation|
5824609|NCT00010517|Procedure|Acupuncture|
5824610|NCT00010504|Procedure|Acupuncture|
5824611|NCT00010491|Procedure|Acupuncture|
5824612|NCT00010491|Procedure|Moxibustion|
5824613|NCT00010478|Procedure|Acupuncture|
5824614|NCT00010465|Procedure|Craniosacral Osteopathic Manipulative Treatment|
5824615|NCT00010465|Drug|Botanicals|
5824616|NCT00009685|Drug|VRC4302|
5824617|NCT00009672|Drug|Nortriptyline|
5824618|NCT00009672|Drug|Morphine|
5824619|NCT00009659|Drug|CDB 2914|
5824620|NCT00009646|Drug|indomethacin|Indocid P.D.A., Merck Frosst, Kirkland, Que., Canada, and Merck, West Point, Pa
5824621|NCT00009646|Drug|Indomethacin|0.1 mg per kilogram of body weight
5824622|NCT00009646|Drug|Placebo|0.1 mg per kilogram of body weight
5824623|NCT00009620|Drug|Phenobarbital|10 mg of phenobarbital per kilogram of body weight intravenously over a period of 20 to 40 minutes (maximal dose, 1000 mg)
5824624|NCT00009620|Drug|Saline|Infusion of normal sal
5824625|NCT00010452|Drug|picibanil|Up to .2 mg per injection, given intralesionally every 6-8 weeks
5824626|NCT00010439|Drug|Alendronate|Pill, 35mg or 70mg weekly, depending upon the body weight for 12 months.
5824627|NCT00010426|Drug|cysteamine hydrochloride|
5824628|NCT00010413|Drug|cyclophosphamide|
5824629|NCT00010413|Drug|filgrastim|
5824630|NCT00010400|Drug|Cyclophosphamide|
5824631|NCT00010400|Drug|filgrastim|
5824632|NCT00010387|Drug|cyclophosphamide|
5824633|NCT00010387|Drug|filgrastim|
5824634|NCT00010374|Device|intramuscular diaphragm electrodes|Conditioning of the diaphragm
5824635|NCT00010374|Device|Intramuscular diaphragm electrodes|to test the safety, efficacy and clinical utility of diaphragm pacing using IM electrodes placed through a laparoscopic approach to achieve artificial ventilation in spinal cord injured patients who have an internal cardiac pacemaker and require full-time ventilator support.
5824636|NCT00010361|Drug|cyclosporine|
5824637|NCT00010361|Drug|fludarabine|
5824638|NCT00010361|Drug|mycophenolate mofetil|
5824639|NCT00010335|Procedure|Stem Cell Transplantation|Participants will receive a stem cell transplantation along with irradiation and the drugs anti-thymocyte globulin, cyclophosphamide, and filgrastim as noted in the text of this record.
5824640|NCT00010335|Device|CD34 selection|CD34+ cells are separated from the rest of the peripheral blood stem cells.
5824641|NCT00009594|Procedure|Naturopathic Medicine|
5824642|NCT00009594|Procedure|Traditional Chinese Medicine|
5824643|NCT00009581|Drug|L-NMMA|
5824644|NCT00009581|Drug|Acetylcholine|
5824645|NCT00009230|Drug|Celecoxib|
5824646|NCT00009217|Drug|Haloperidol-Haloperidol|Haloperidol open label flexible dose 1-5 mg daily for 20 weeks followed by haloperidol double-blind 1-5 mg for 24 weeks
5824647|NCT00009217|Drug|Haloperidol-Placebo|Haloperidol open-label flexible dose of 1-5 mg for 20 weeks followed by placebo double-blind for 24 weeks
5824648|NCT00009204|Drug|Citalopram [Celexa]|
5824649|NCT00009204|Drug|Perphenazine [Trilafon]|
5824650|NCT00009191|Drug|Sertraline [Zoloft]|
5824651|NCT00009048|Drug|EMD 128130|
5824652|NCT00009048|Drug|IV Levodopa|
5824653|NCT00009178|Drug|Fluoxetine|
5824654|NCT00009178|Behavioral|Guided Self-Help|
5824655|NCT00009009|Drug|immunosuppressive regimen designed to complement HAART|
5824656|NCT00008801|Drug|hOKT3gamma1 (Ala-ala)|
5824657|NCT00008775|Device|Pressure support ventilation|
5824658|NCT00008736|Drug|metoclopramide|
5824659|NCT00008827|Behavioral|Behavioral weight loss|
5824660|NCT00008515|Drug|Fluocinolone|
5824661|NCT00008476|Drug|Capsaicin|
5824662|NCT00008450|Procedure|Allogeneic Bone Marrow Transplantation|Undergo allogeneic bone marrow transplant
5824663|NCT00008450|Drug|Cyclosporine|Given PO or IV
5824664|NCT00008450|Other|Laboratory Biomarker Analysis|Correlative studies
5824665|NCT00008450|Drug|Mycophenolate Mofetil|Given PO or IV
5824666|NCT00008450|Procedure|Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation|Undergo nonmyeloablative allogeneic hematopoietic stem cell transplant
5824667|NCT00008450|Radiation|Total-Body Irradiation|Undergo TBI
5824668|NCT00007800|Behavioral|Behavioral Group Weight Loss Intervention|
5824669|NCT00007800|Behavioral|Motivational Interviewing|
5824670|NCT00007670|Drug|Carbamazepine|
5824673|NCT00007657|Procedure|Intensive medical therapy|
5824674|NCT00007657|Procedure|Percutaneous Coronary Intervention (PCI) plus intensive medical therapy|
5824675|NCT00007774|Drug|Haloperidol|
5824676|NCT00007774|Drug|Olanzapine|
5824677|NCT00007761|Behavioral|Bipolar Disorder Program|
5824678|NCT00007761|Behavioral|Usual (psychiatric) Care|
5824679|NCT00007748|Behavioral|Aerobic exercise|
5824680|NCT00007748|Behavioral|Cognitive behavioral therapy|
5824681|NCT00007735|Drug|Doxycycline (200mg/day) or Placebo|
5824682|NCT00007683|Drug|Warfarin titrated to an INR of 2.5-3.0|anticoagulation (administered without blinding) titrated to a target INR of 2.5 to 3.0, monitored by measurements at 6 week intervals after initial titration and stabilization.
5824683|NCT00007683|Drug|Aspirin|an antiplatelet agent whose mechanism is inhibition of thromboxane, a platelet activator) administered in a double blind manner.
5824684|NCT00007683|Drug|Clopidogrel 75|(an antiplatelet agent whose mechanism is ADP inhibition) administered in a double blind manner)
5824685|NCT00007644|Procedure|Radical prostatectomy|Surgical removal of the prostate
5824686|NCT00007631|Drug|Tretinoin 0.1% cream or placebo|
5824687|NCT00007631|Other|Placebo|Patients receive placebo for same amount of time
5824688|NCT00007605|Drug|Amiodarone|Patients assigned will receive 400 mg bid for 14 days, 400 mg QAM and 200 mg QHS for 14 days, 300 mg qd for 48 weeks, then 200 mg qd.
5824689|NCT00007605|Drug|Sotalol|Patients assigned will receive 80 mg bid for 7 days and 160 mg bid thereafter.
5824690|NCT00007592|Drug|Chlorthalidone|
5824691|NCT00007592|Drug|Furosemide|
5824692|NCT00007527|Drug|naloxone|
5824693|NCT00007527|Drug|buprenorphine|
5824694|NCT00007501|Biological|Varicella-zoster vaccine|Immunization with 0.5 ml, live, attenuated (Oka/Merck) varicella-zoster vaccine.
5824695|NCT00007501|Biological|Placebo|Placebo vaccine
5824696|NCT00007475|Procedure|Plasma exchange|A course of plasma exchange of 5 treatments over 10 days, then administration of cyclophosphamide.
5824697|NCT00007475|Drug|Cyclophosphamide|For GFR > 50 ml/min/1.73 m2 received oral cyclophosphamide at a dose of 2 mg/kg/ day for 3 months. For GFR < 50 ml/min/1.73 m2 but > 10 ml/min/1.73 m2 will receive oral cyclophosphamide at a 25% reduced dose or 1.5 mg/kg/d for 3 months.
5824698|NCT00007358|Drug|Dexamethasone or other corticosteroid|Administered during the third trimester of pregnancy
5824699|NCT00007345|Drug|Romidepsin|
5824700|NCT00007306|Drug|Parathyroid hormone ointment|
5824701|NCT00007293|Device|UV-B Lightsource and Fiber Optic Comb|
5824702|NCT00007280|Device|Bioengineered skin|
5824703|NCT00007267|Behavioral|Cognitive behavioral therapy|
5824704|NCT00007267|Behavioral|Disease/health education|
5824705|NCT00007267|Behavioral|Self-help cognitive behavioral intervention facilitated by a psychologist|
5824706|NCT00007254|Drug|Pain relief for pressure ulcers|
5824707|NCT00007241|Device|Isometric exercise|
5824708|NCT00007189|Drug|Naproxen Sodium (Aleve)|
5824709|NCT00007189|Drug|Celecoxib (Celebrex)|
5824710|NCT00007163|Drug|J695|
5824711|NCT00007150|Procedure|Phlebotomy|Therapeutic phlebotomy, the periodic, frequent removal of iron contained in the hemoglobin of red blood cells.
5824712|NCT00007085|Device|Tomography, X-ray Computed|
5824713|NCT00007059|Drug|mycophenolate mofetil|
5824714|NCT00007033|Drug|magnesium gluconate|
5824715|NCT00007033|Drug|magnesium sulfate|
5824716|NCT00007020|Drug|Cholic Acids|10-15 mg/kg body weight/day taken orally.
5824717|NCT00006565|Device|HEPA Air Cleaner|Placement of two active HEPA air cleaners in the homes of children
5824718|NCT00006565|Device|Placebo Filtration Unit|Placement of inactive filtration unit in the homes
5824719|NCT00006519|Drug|Capravirine|
5824720|NCT00006517|Device|bright light box|10,000 lux bright light therapy
5824721|NCT00006517|Device|dawn simulator|gradual rise in bedroom illumination prior to wake-up
5824722|NCT00006517|Device|high-output negative ion generator|automated air ion delivery in bedroom prior to wake-up
5824723|NCT00006517|Device|low-output negative ion generator|automated air ion delivery in bedroom prior to wake-up
5824724|NCT00006517|Device|dawn light pulse|rectangular light pulse matched for lux.time of dawn simulation delivered prior towake-up
5824725|NCT00006516|Behavioral|Infant stimulation|
5824726|NCT00006508|Procedure|Controlled hypoglycemia using insulin|
5824727|NCT00006508|Procedure|formula meal|
5824728|NCT00006505|Other|Islet Transplantation|Islet cell transplantation. This study will test whether a new islet transplant procedure will enable patients with type 1 diabetes mellitus to stop insulin therapy
5824729|NCT00006501|Procedure|ECG|A diagnostic tool that is routinely used to assess the electrical and muscular functions of the heart (non-experimental).
5824730|NCT00006493|Drug|Rosiglitazone|
5824731|NCT00006489|Behavioral|Cognitive-Behavioral Therapy|Twelve weekly 90-minute individual therapy sessions followed by (6) 90-minute sessions every other week
5824732|NCT00006489|Drug|Naltrexone|Daily dosing 100 mg for 24 weeks
5824733|NCT00006489|Drug|Placebo|Pill Placebo daily dosing 24 weeks
5824734|NCT00006488|Drug|recombinant-methionyl human glial cell line-derived neurotrophic factor|
5824735|NCT00006450|Drug|Phenylbutyrate|
5824736|NCT00006449|Drug|naltrexone (Revia)|
5824737|NCT00006449|Behavioral|broad spectrum treatment|
5824738|NCT00006449|Behavioral|motivational enhancement therapy|
5824739|NCT00006507|Behavioral|Occupational Therapy|
5824740|NCT00006448|Behavioral|cognitive therapy|
5824741|NCT00006448|Procedure|Physical Therapy|
5824742|NCT00006448|Drug|Methadone|
5824743|NCT00006447|Procedure|Social Support|
5824744|NCT00006446|Procedure|Training in parenting skills and communication|
5824745|NCT00006445|Procedure|Ultrasound|
5824746|NCT00006445|Procedure|Serum screen|
5824747|NCT00006439|Behavioral|Counseling in the home|
5824748|NCT00006438|Device|Shoes with Rocker Soles|
5824823|NCT00006194|Behavioral|Exercise|
5824749|NCT00006436|Biological|Rituximab|2 doses of rituximab every cycle: first dose on Day 1 and 2nd dose on Day 5
5824750|NCT00006436|Biological|filgrastim|Figrastim day 6 until ANC reaches 5000 after the nadir, every cycle
5824751|NCT00006436|Drug|EPOCH|combination chemotheray: EPOCH every 3 weeks for minimum of 3 cycles and max of 6 cycles
5824752|NCT00006434|Biological|tumor-pulsed dendritic cells|
5824753|NCT00006433|Drug|Doxil|
5824754|NCT00006433|Procedure|heat treatment|
5824755|NCT00006432|Procedure|very low fat diet|
5824756|NCT00006431|Biological|DC RCC-RNA|
5824757|NCT00006430|Biological|Autologous dendritic cells transfected with amplified tumor RNA|
5824758|NCT00006429|Procedure|body weight-supported treadmill training|
5824759|NCT00006428|Drug|Amitriptyline|
5824760|NCT00006427|Drug|Amitriptyline|
5824761|NCT00006426|Procedure|Achilles tendon-lengthening surgery|
5824762|NCT00006422|Procedure|current standard of care treatments|
5824763|NCT00006418|Procedure|DNA collection|
5824764|NCT00006417|Procedure|Stem cell transplantation|
5824765|NCT00006413|Procedure|Stem cell transplantation|
5824766|NCT00006411|Other|corneas assigned by donor age group|A web-based computer program was used to select and assign a cornea by donor age group from those available at the eye bank that met the study eligibility criteria. The program randomly selected a cornea based on a two-level minimization procedure which attempted first to balance for each surgeon the number of corneas from donors >=66 and <66 years old and then, when possible, to balance among age subgroups of 10-35, 36-50, 51-65, 66-70, and 71-75 years. The assignment was made without regard to recipient age or any other subject characteristics.
5824767|NCT00006409|Behavioral|Trial of Activity for Adolescent Girls (TAAG)|Intervention activities were designed to create (1) environmental and organizational changes supportive of physical activity and (2) cues, messages, and incentives to be more active. The intervention was designed to establish more opportunities, improve social support and norms, and increase self-efficacy, outcome expectations, and behavioral skills to foster greater moderate-vigorous physical activity (MVPA). An innovative feature of TAAG was linking school and community agencies to promote activity programs for girls. Finally, a TAAG Program Champion component was developed to foster sustainability after the 2-year staff-directed intervention. TAAG investigators recruited and trained Program Champions during the staff-directed intervention phase to promote maintenance of the program.
5824768|NCT00006405|Behavioral|Exercise|
5824769|NCT00006401|Drug|iNO|Inhaled Nitric Oxide for Preventing Chronic Lung Disease in Premature Infants
5824770|NCT00006401|Other|Placebo|Inhaled Nitrogen
5824771|NCT00006400|Drug|Hydroxyurea|Participants will receive hydroxyurea.
5824772|NCT00006400|Drug|Placebo|Participants will receive placebo.
5824773|NCT00006398|Drug|Timolol Maleate|
5824774|NCT00006398|Drug|Placebo|
5824775|NCT00006394|Drug|growth hormone|
5824776|NCT00006337|Drug|KW-6002|
5824777|NCT00006337|Drug|IV Levodopa|
5824778|NCT00006332|Drug|Tetrathiomolybdate|
5824779|NCT00006331|Procedure|renal transplant|
5824780|NCT00006330|Drug|Digoxin|
5824781|NCT00006330|Drug|Hawthorn|
5824782|NCT00006329|Procedure|Minimally invasive radioguided parathyroidectomy|
5824783|NCT00006320|Procedure|determine blood levels of anti-HIV drugs|
5824784|NCT00006305|Procedure|Angioplasty, Transluminal, Percutaneous Coronary, other catheter-based interventions|Angioplasty, Transluminal, Percutaneous Coronary, other catheter-based interventions
5824785|NCT00006305|Procedure|Coronary Artery Bypass|Coronary Artery Bypass
5824786|NCT00006305|Drug|Biguanides, thiazolidinediones|Biguanides, thiazolidinediones
5824787|NCT00006305|Drug|Insulin, sulfonylurea|Insulin, sulfonylurea
5824788|NCT00006305|Drug|ACE Inhibitors, Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers|ACE Inhibitors, Angiotensin Receptor Blockers, Beta Blockers, Calcium Channel Blockers
5824789|NCT00006299|Drug|Celebrex|
5824790|NCT00006294|Drug|Chlorthalidone|participant's drug dose will be titrated from 12.5mg to 25mg over the course of the study
5824791|NCT00006294|Drug|Lisinopril|participant's drug dose will be titrated from 10mg to 40mg over the course of the study
5824792|NCT00006294|Drug|Amlodipine|participant's drug dose will be titrated from 10mg to 40mg over the course of the study
5824793|NCT00006294|Drug|Doxazosin|participant's drug dose will be titrated from 2mg to 8mg over the course of the study
5824794|NCT00006292|Drug|Infliximab|
5824795|NCT00006289|Drug|Placebo|4 tabs b.i.d.
5824796|NCT00006289|Drug|Neurotropin|4 tabs b.i.d.
5824797|NCT00006286|Drug|Fluoxetine|
5824798|NCT00006286|Behavioral|Psychotherapy|
5824799|NCT00006276|Drug|Micellar Paclitaxel|
5824800|NCT00006280|Drug|Tobramycin for Inhalation|
5824801|NCT00006275|Drug|calcitriol|
5824802|NCT00006270|Drug|cosyntropin|
5824803|NCT00006270|Drug|metyrapone|
5824804|NCT00006206|Drug|naltrexone (Revia)|
5824805|NCT00006206|Drug|acamprosate (Campral)|
5824806|NCT00006205|Drug|ondansetron + cognitive behavioral therapy|ondansetron (4 mcg/kg b.i.d)
5824807|NCT00006205|Drug|topiramate + cognitive behavioral therapy|topiramate (up to 300 mg/day)
5824808|NCT00006205|Drug|Placebo + cognitive behavioral therapy|placebo
5824809|NCT00006205|Drug|ondansetron + topiramate + cognitive behavioral therapy|ondansetron (4 mcg/kg b.i.d) + topiramate (up to 300 mg/day)
5824810|NCT00006204|Drug|naltrexone (Revia)|
5824811|NCT00006204|Drug|fluoxetine (Prozac)|
5824812|NCT00006203|Drug|naltrexone (Revia)|
5824813|NCT00006202|Drug|Lutein|
5824814|NCT00006200|Drug|thalidomide|
5824815|NCT00006200|Drug|dacarbazine|
5824816|NCT00006199|Drug|R115777 (farnesyl transferase inhibitor)|
5824817|NCT00006199|Drug|Topotecan|
5824818|NCT00006198|Drug|thalidomide|
5824819|NCT00006198|Procedure|chemoembolization with doxorubicin/collagen|
5824820|NCT00006196|Drug|Vitamin D|
5824821|NCT00006195|Drug|risperidone|
5824822|NCT00006195|Drug|olanzapine|
5824825|NCT00006190|Drug|Nelfinavir mesylate|
5824826|NCT00006190|Drug|Stavudine|
5824827|NCT00006190|Drug|Lamivudine|
5824828|NCT00006190|Drug|Efavirenz|
5824829|NCT00006187|Drug|Investigational drug|
5824830|NCT00006186|Procedure|Autologous fresh whole blood|
5824831|NCT00006184|Drug|Myeloma Immunoglobulin Idiotype Vaccine|3 subcutaneous (SC) injections of myeloma protein within 10 weeks before stem cell collection the first (week 0), second (week 2), and third injection (week 6) with Id-KLH (0.5 mg SC day 1)
5824832|NCT00006184|Drug|Bortezomib|Induction chemotherapy: 1.3 mg/m^2 bolus intravenous injection twice weekly for 2 weeks (days 1, 4, 8, 11) followed by 10 day rest period (day 12-21)
5824833|NCT00006184|Drug|Cyclophosphamide|Induction chemotherapy: 600 mg/m^2 day 4 Transplant: 1200 mg/m^2 intravenous x 4 days (days -6, -5, -4, -3)
5824834|NCT00006184|Drug|Cyclosporine|Transplant: 2 mg/kg intravenous every 12 hours continuous intravenous or by mouth (PO) until day + 180
5824835|NCT00006184|Drug|Doxorubicin hydrochloride|Induction chemotherapy: 10 mg/m^2 day continuous intravenous (CIV) days 1-3
5824836|NCT00006184|Drug|Etoposide|Induction chemotherapy: 50 mg/m^2 day continuous intravenous days 1-3
5824837|NCT00006184|Drug|Fludarabine phosphate|Induction chemotherapy: 25 mg/m^2 day intravenous days 1-3 Transplant: 30 mg/m^2 day x 4 days (days -6, -5, -4, -3 )
5824838|NCT00006184|Drug|Prednisone|60 mg/m^2 day 1-4
5824839|NCT00006184|Drug|Vincristine Sulfate|Induction chemotherapy: 0.5 mg/m^2 day continuous intravenous days 1-3
5824840|NCT00006184|Drug|Methotrexate|Transplant: 5 mg/m^2 intravenous on days +1, +3, +6, +11
5824841|NCT00006184|Biological|GMCSF (granulocyte macrophage colony stimulating factor)|250 mcg/m^2 subcutaneously every day, days 1-4
5824842|NCT00006184|Biological|GCSF (granulocyte colony stimulating factor)|10 mcg/kg per day subcutaneously daily from day 5 until absolute neutrophil count (ANC) > 1000/ul x 2 days
5824843|NCT00006185|Drug|Avandia administration for 6-12 weeks|
5824844|NCT00006183|Procedure|Cardiopulmonary Bypass with Two Different Intra-Operative Hematocrits|
5824845|NCT00006183|Procedure|Thoracic Surgery|
5824846|NCT00006182|Procedure|Blood Transfusion|
5824847|NCT00006399|Drug|Donepezil|
5824848|NCT00006399|Drug|Estrogen|
5824849|NCT00006399|Drug|Progesterone|
5824850|NCT00006181|Behavioral|Team-based intervention|
5824851|NCT00006181|Behavioral|One-on-one intervention|
5824852|NCT00006180|Drug|Alendronate|
5824853|NCT00006178|Drug|Sirolimus|
5824854|NCT00006178|Drug|Thymoglobulin|
5824855|NCT00006174|Drug|Letrozole|
5824856|NCT00006172|Device|Bright light box|60-min light therapy shortly after awakening
5824857|NCT00006172|Device|High-output negative ion generator|60-min high-density ion exposure shortly after awakening
5824858|NCT00006172|Device|Low-output negative ion generator|60-min low-density ion exposure shortly after awakening
5824859|NCT00006170|Drug|Bupropion|smoking cessation medication aid
5824860|NCT00006170|Drug|Placebo|A matched placebo pill
5824861|NCT00006170|Behavioral|weight concerns intervention|cognitive behavioral treatment to address weight concners
5824862|NCT00006170|Behavioral|smoking cessation intervention|Cognitive behavioral intervention for smoking cessation
5824863|NCT00006156|Other|Control|No injection of FSH
5824864|NCT00006156|Drug|Drug: FSH|FSH Stimulation Test
5824865|NCT00006169|Behavioral|Behavioral Treatment|
5824866|NCT00006168|Drug|Methotrexate|
5824867|NCT00006167|Drug|oxandrolone|
5824868|NCT00006167|Behavioral|Progressive Resistance Training|
5824869|NCT00006166|Procedure|Transjugular intrahepatic portasystemic shunts (TIPS)|
5824870|NCT00006166|Procedure|Total paracentecis (TP)|
5824871|NCT00006165|Behavioral|'Ohana (Family) Support Lifestyle Intervention|
5824872|NCT00006164|Drug|Peginterferon alfa-2a + Ribavirin|Peginterferon alfa-2a 180 mcg/week injection, for 24 weeks, plus 1000-1200 mg Ribavirin oral (prescribed according to weight <75 kg, >75 kg) daily in two divided doses for 24 weeks
5824873|NCT00006164|Drug|Peginterferon alfa-2a|90 mcg/week injection, for 3.5 years
5824874|NCT00006163|Behavioral|Personalized Self-management|
5824875|NCT00006163|Behavioral|Community Resources|
5824876|NCT00006162|Behavioral|exercise and diet|
5824877|NCT00006161|Procedure|Transjugular Intrahepatic Portosystemic Shunt (TIPS)|
5824878|NCT00006161|Procedure|Distal Splenorenal Shunt|
5824879|NCT00006160|Behavioral|home based worker|
5824880|NCT00006159|Behavioral|lifestyle (exercise, diet, and family and community support)|
5824881|NCT00006158|Drug|Testosterone|
5824882|NCT00006157|Drug|Desipramine|
5824883|NCT00006157|Behavioral|Cognitive Behavioral Treatment|
5824884|NCT00006151|Behavioral|Behavioral Therapy|Weekly behavioral therapy based on Project Match Motivational Therapy clinical manual plus systematic cigarette tapering.
5824885|NCT00006077|Drug|NS2330|
5824886|NCT00006077|Drug|Levodopa and Domperidone|
5824887|NCT00006142|Behavioral|phenylalanine restricted diet|
5824888|NCT00006137|Drug|enalapril|
5824889|NCT00006136|Drug|arginine butyrate|
5824890|NCT00006136|Drug|epoetin alfa|
5824891|NCT00006135|Drug|acyclovir|
5824892|NCT00006133|Drug|estradiol|
5824893|NCT00006133|Drug|ethinyl estradiol|
5824894|NCT00006133|Drug|medroxyprogesterone|
5824895|NCT00006133|Drug|norethindrone|
5824896|NCT00006132|Drug|acyclovir|
5824897|NCT00006131|Drug|Valacyclovir|
5824898|NCT00006130|Procedure|Core decompression|
5824899|NCT00006129|Drug|testosterone|
5824900|NCT00006127|Drug|amifostine|
5824901|NCT00006072|Drug|Rituxan|
5824902|NCT00006070|Drug|etanercept (Enbrel)|
5824903|NCT00006068|Procedure|Pancreatic Islet Transplantation|
5824904|NCT00005937|Drug|Antithymocyte globulin|Antithymocyte globulin (ATG) intravenous infusion: 40mg/kg/day. Infusion over 6 hours on day 1-4.
5825055|NCT00005567|Behavioral|Parental knowledge and beliefs about infant sleep position|
5824905|NCT00005937|Drug|Cyclosporine|Cyclosporine (CsA) intravenous infusion: 5mg/kg. Infusion on day 14 administered twice a day.
5824906|NCT00005935|Drug|Mycophenolate mofetil|
5824907|NCT00005935|Drug|Cyclosporine|
5824908|NCT00005934|Drug|5-Azacytidine|
5824909|NCT00006063|Drug|pancrelipase with bicarbonate|
5824910|NCT00006061|Drug|phosphatidylcholine|
5824911|NCT00006060|Drug|standard gadolinium contrast|
5824912|NCT00006056|Drug|anti-thymocyte globulin|
5824913|NCT00006056|Drug|busulfan|
5824914|NCT00006056|Drug|cyclophosphamide|
5824915|NCT00006056|Drug|cyclosporine|
5824916|NCT00006056|Drug|etoposide|
5824917|NCT00006056|Drug|filgrastim|
5824918|NCT00006056|Drug|methotrexate|
5824919|NCT00006056|Procedure|allogeneic hematopoietic stem cell transplantation|
5824920|NCT00006055|Drug|anti-thymocyte globulin|
5824921|NCT00006055|Drug|cyclophosphamide|
5824922|NCT00006055|Drug|cyclosporine|
5824923|NCT00006055|Drug|filgrastim|
5824924|NCT00006055|Drug|methylprednisolone|
5824925|NCT00006055|Drug|prednisone|
5824926|NCT00006055|Procedure|Autologous Peripheral Blood Stem Cell Transplantation|
5824927|NCT00006054|Drug|anti-thymocyte globulin|
5824928|NCT00006054|Drug|busulfan|
5824929|NCT00006054|Drug|cyclophosphamide|
5824930|NCT00006054|Drug|cyclosporine|
5824931|NCT00006054|Drug|etoposide|
5824932|NCT00006054|Drug|methotrexate|
5824933|NCT00006054|Drug|methylprednisolone|
5824934|NCT00006054|Drug|prednisone|
5824935|NCT00006054|Procedure|Allogeneic Bone Marrow Transplantation|
5824936|NCT00005928|Drug|Ramipril|
5824937|NCT00005925|Drug|Muscimol|
5824938|NCT00005922|Behavioral|Partial schedule of pharmacotherapeutic reinforcement|Dose of 0.1% of Aristocort A on 1-2 of every 4 days for a period of up to 14 weeks.
5824939|NCT00005922|Drug|Dose control for Arm B|Dose of 0.025-0.05% of Aristocort A 2 times per day for a period of up to 14 weeks.
5824940|NCT00005922|Other|Standard pharmacotherapeutic protocol|Full dose of Aristicort A (0.1%) 2 times per day for a period of up to 14 weeks.
5824941|NCT00005916|Drug|rV-PSA|
5824942|NCT00005916|Drug|rF-PSA|
5824943|NCT00005916|Drug|rV-B7.1|
5824944|NCT00005910|Procedure|Intraoperative ultrasound|
5824945|NCT00005908|Drug|Docetaxel - Dose A|Dose A-Cohort 1 Docetaxel 75 mg/m^2 intravenous day 1
5824946|NCT00005908|Drug|Anastrozole|1 mg orally daily for five years
5824947|NCT00005908|Drug|cyclophosphamide|600 mg/m^2 will be diluted in 100 mL 0.9% normal saline (NS) and administered intravenously over 30 minutes on day 1
5824948|NCT00005908|Drug|Docetaxel - Dose B|Dose B - Cohort 2 Docetaxel 60 mg/m^2 intravenous day 1
5824949|NCT00005908|Drug|Doxorubicin hydrochloride|60 mg/m^2 will be administered as a slow intravenous push on day 1
5824950|NCT00005908|Drug|Tamoxifen Citrate|20 mg/day orally for five years
5824951|NCT00005908|Drug|Capecitabine - Dose B|Dose B - Cohort 2 capecitabine 937.5 mg/m^2 orally twice daily day 2-15
5824952|NCT00005908|Drug|Capecitabine - Dose A|capecitabine 1000 mg/m^2 orally twice daily day 2-15 for 4 cycles
5824953|NCT00005906|Drug|Octreotide|Treatment with octreotide starts at a dose of 50 micrograms(ug) twice a day which is increased to 100 ug twice a day after two weeks and to 200 ug twice a day two weeks later. After two months, if there is no response the dose shall be increased to 400 ug twice a day.
5824954|NCT00005905|Drug|hu Leptin (A-100)|
5824955|NCT00005903|Drug|GDNF & Synchro Med Infusion System|
5824956|NCT00005901|Drug|Pamidronate (Aredia)|Patients receive a dose of 1mg/kg/cycle (3-day infusion = 1 cycle)
5824957|NCT00005898|Drug|anti-thymocyte globulin|
5824958|NCT00005898|Drug|cyclophosphamide|
5824959|NCT00005898|Drug|cyclosporine|
5824960|NCT00005898|Drug|filgrastim|
5824961|NCT00005898|Drug|fludarabine|
5824962|NCT00005898|Drug|methylprednisolone|
5824963|NCT00005896|Drug|filgrastim|
5824964|NCT00005896|Genetic|Autologous stem cells transduced with FACC retroviral vector|
5824965|NCT00005896|Procedure|Autologous Stem Cell Transplantation|
5824966|NCT00005893|Drug|anti-thymocyte globulin|
5824967|NCT00005893|Drug|busulfan|
5824968|NCT00005893|Drug|cyclophosphamide|
5824969|NCT00005893|Procedure|Bone marrow transplantation|
5824970|NCT00005892|Drug|cyclophosphamide|
5824971|NCT00005892|Procedure|Allogeneic Bone Marrow Transplantation|
5824972|NCT00005891|Drug|cyclophosphamide|
5824973|NCT00005891|Procedure|Allogeneic Bone Marrow Transplantation|
5824974|NCT00005890|Drug|corticotropin|
5824975|NCT00005889|Drug|alanine|
5824976|NCT00005889|Drug|amino acids|
5824977|NCT00005889|Drug|glucagon|
5824978|NCT00005889|Drug|glucose|
5824979|NCT00005889|Drug|glutamine|
5824980|NCT00005889|Drug|glycerol|
5824981|NCT00005889|Drug|insulin|
5824982|NCT00005889|Drug|leucine|
5824983|NCT00005889|Drug|lipids|
5824984|NCT00005889|Drug|urea|
5824985|NCT00005888|Behavioral|Fortified Pasteurized Donor Human Milk supplement|
5824986|NCT00005888|Behavioral|Preterm Formula supplement|
5824987|NCT00005785|Drug|GCSF Mobilized Allogeneic PBSC Cultured w/Cytokines; Transduced w/RV|
5824988|NCT00005782|Drug|Granulocyte colony-stimulating factor|
5824989|NCT00005782|Procedure|Leukapheresis|
5824990|NCT00005780|Drug|EPOCH-R|EPOCH-R for 6 cycles
5824991|NCT00005780|Biological|GM-CSF|GM-CSF monthly with the vaccine for 5 doses
5824992|NCT00005780|Biological|Idiotype vaccine|1 injection of vaccine monthly for 5 doses
5824993|NCT00005778|Drug|High-dose immunoablative therapy|"High dose cyclophosphamide for 4 days.~NIH monthly IV cytoxan for 6 months followed by quarterly for 2 years."
5824994|NCT00005777|Procedure|Minimal mechanical ventilation management|Partial pressure of carbon dioxide (PCO2) target (>52 mm Hg)
5825056|NCT00005566|Behavioral|Desperation Scale|
5824995|NCT00005777|Procedure|Routine mechanical ventilation management|Partial pressure of carbon dioxide (PCO2) target <48 mm Hg)
5824996|NCT00005777|Drug|Dexamethasone|Treatment with the study medication was initiated within 24 hours after birth. The dexamethasone-treated infants received a 10-day tapered course (0.15 mg of dexamethasone per kilogram per day for three days, followed by 0.10 mg per kilogram for three days, 0.05 mg per kilogram for two days, and 0.02 mg per kilogram for two days), with the daily dose divided in half and given at 12-hour intervals intravenously or orally, if an intravenous catheter was no longer in place.
5824997|NCT00005777|Drug|Placebo|The infants in the placebo groups received equal volumes of saline.
5824998|NCT00005776|Drug|Inhaled nitric oxide|Inhaled Nitric oxide at a concentration of 20 ppm
5824999|NCT00005776|Drug|Placebo|100% Oxygen
5825000|NCT00005775|Drug|Glutamine|Infants randomized to glutamine supplementation will receive glutamine any time that parenteral nutrition is required during the first 120 days of hospitalization.
5825001|NCT00005775|Drug|Placebo|TrophAmine given any time that parenteral nutrition is required during the first 120 days of hospitalization.
5825002|NCT00005774|Drug|Early surfactant|Early surfactant followed by extubation within 30 minutes and application of continuous positive airway pressure (CPAP)
5825003|NCT00005774|Drug|Standard practice|Surfactant according to current center practice, only after initiation of mechanical ventilation.
5825004|NCT00005773|Drug|Inhaled Nitric Oxide|Study gas was initiated at a concentration of 5 ppm, and the dose was increased to 20 ppm when the infant had <=20 mm Hg increase in PaO2 (less than full response).
5825005|NCT00005773|Drug|Standard iNO therapy|Begin a sham initiation of iNO in term and near-term infants in respiratory failure with an oxygenation index (OI) between 15-25; initiated actual iNO therapy based on standard threshold (OI >=25).
5825006|NCT00005772|Device|Induced hypothermia|Whole-body cooling using the Blanketrol II or III Units in the Automatic Control Mode with a YSI 400 series temperature probe placed in the distal esophagus over a 96-hour period
5825007|NCT00005772|Device|Control|Control group: standard care
5825008|NCT00005771|Device|Visual utrasound feedback|
5825009|NCT00005771|Procedure|Abdominal Hollowing Exercise|
5825010|NCT00005770|Device|Acupuncture|
5825011|NCT00005769|Drug|Hormone Replacement Therapy|
5825012|NCT00005768|Drug|Estrogen|
5825013|NCT00005766|Drug|Creatinine|
5825014|NCT00005765|Drug|nicotine|
5825015|NCT00005765|Drug|alcohol|
5825016|NCT00005675|Drug|Oral bovine type I collagen|500 mcg of CI daily for 15 months
5825017|NCT00005675|Drug|Placebo|CI placebo daily for 15 months
5825018|NCT00005674|Drug|Creatine|
5825019|NCT00005743|Behavioral|exercise|
5825020|NCT00005743|Behavioral|weight loss|
5825021|NCT00005739|Behavioral|Community-based directly observed therapy (DOT)|A community-based intervention conducted by trained graduates of a TB directly observed therapy (DOT) program (peer workers)
5825022|NCT00005739|Behavioral|Clinic directly observed therapy (DOT)|A traditional self-administered preventive treatment
5825023|NCT00005727|Behavioral|Intervention|Classroom-based nutrition education curriculum designed for individuals with low literacy skills.
5825024|NCT00005724|Behavioral|Computer Program Intervention Group|A user-friendly, interactive computer program providing dietary counseling tailored to the needs of the participant.
5825025|NCT00005724|Other|Minimal Intervention Group|Dietary Information pamphlets.
5825026|NCT00005724|Behavioral|Health Counselor Intervention Group|Food for Heart Program - a structured diet treatment program for low income patients with high cholesterol, given by a health counselor at 4 treatment visits.
5825027|NCT00005713|Behavioral|Continuing, preventative care|Training for intervention clinic staff was based on National Asthma Education and Prevention Program guidelines for the diagnosis and management of asthma, and included screening to identify new cases and health education to improve family management.
5825028|NCT00005711|Behavioral|Asthma self-management education|"Treatment group children and their families participated in the patient education program which consisted of four separate one-hour sessions. The topics were: symptoms of asthma, causes of asthma (triggers), medications, and peak flow. A bilingual nurse educator working one-on-one with the child and family members delivered these four sessions. The four sessions were delivered over a six week period. Culturally sensitive educational materials include both print (flip charts, take-home brochures) and videotape materials. The videotapes feature children from the clinic and highlight how they successfully manage their asthma. All materials are available in both English and Spanish."
5825029|NCT00005684|Drug|warfarin|
5825030|NCT00005684|Drug|heparin|
5825031|NCT00005555|Behavioral|Exercise|
5825032|NCT00005553|Procedure|Catheter Ablation|
5825033|NCT00005520|Drug|Hydrochlorothiazide|
5825034|NCT00005520|Drug|Candesartan|
5825035|NCT00005399|Other|No interventions|No interventions
5825036|NCT00005398|Other|There is no intervention|No applicable
5825037|NCT00005305|Other|No interventions - observational study|
5825038|NCT00005195|Procedure|Catheter ablation|
5825039|NCT00005137|Other|exercise program|subjects were measured before and after a 20-week long on-site exercise training program
5825040|NCT00005673|Drug|Capravirine|
5825041|NCT00005669|Drug|Metformin HCL|Medication studied for ability to alter body weight and body composition.
5825042|NCT00005669|Drug|Placebo|Control capsules for metformin
5825043|NCT00005666|Procedure|PET scan use in radiotherapy planning|
5825044|NCT00005665|Drug|interferon alpha|
5825045|NCT00005658|Drug|Glycine|
5825046|NCT00005655|Biological|rh IL-12|rhIL-12 will be administered intravenously on days 2, 4, 6, 10, 12 and 14 of each cycle.
5825047|NCT00005655|Biological|rh IL-2|rhIL-2 will be administered intravenously every 8 hours x 3 doses on days 1 and 9 of each cycle.
5825048|NCT00005654|Drug|clomiphene citrate|
5825049|NCT00005654|Drug|metformin|
5825050|NCT00005652|Drug|rituximab|
5825051|NCT00005575|Drug|Imipramine|
5825052|NCT00005575|Behavioral|Cognitive-behavior therapy|
5825053|NCT00005571|Drug|h5G1.1-mAb|
5825054|NCT00005569|Drug|SLPI (Secretory Leukocyte Protease Inhibitor)|
5825057|NCT00005119|Procedure|Measures of calcium and bone turnover|
5825058|NCT00005117|Drug|pravastatin|
5825059|NCT00005112|Drug|Human recombinant growth hormone|
5825060|NCT00005116|Behavioral|psychotherapy|
5825061|NCT00005110|Drug|Salmeterol|
5825062|NCT00005110|Drug|Albuterol|
5825063|NCT00005108|Drug|Estradiol|
5825064|NCT00005108|Drug|Progesterone|
5825065|NCT00005107|Drug|N-monomethyl-L-arginine|
5825066|NCT00005104|Drug|clomiphene citrate|
5825067|NCT00005104|Drug|metformin|
5825068|NCT00005015|Drug|Fluoxetine|
5825069|NCT00005014|Drug|Risperidone|
5825070|NCT00005013|Drug|Sertraline|
5825071|NCT00005013|Drug|Hypericum perforatum (St. John's wort)|
5825072|NCT00005007|Drug|Etanercept|
5825073|NCT00005006|Drug|Parathyroid Hormone|Alendronate 70mg/week; Teriparatide 20mcg/ day
5825074|NCT00005006|Drug|Alendronate|Alendronate 70mg/week
5825075|NCT00005006|Drug|Teriparatide|Teriparatide 20mcg/day
5825076|NCT00005005|Drug|PTH|
5825077|NCT00005005|Drug|Alendronate|
5825078|NCT00004997|Drug|Leucovorin|
5825079|NCT00004993|Drug|Parathyroid hormone (hPTH 1-34)|
5825080|NCT00004992|Behavioral|Intensive lifestyle|
5825081|NCT00004992|Drug|Metformin|
5825082|NCT00004992|Drug|Placebo|
5825083|NCT00004990|Drug|Dexamethasone|
5825084|NCT00004988|Drug|VNP20009|
5825085|NCT00004984|Drug|Parenteral Insulin|Subcutaneous injections of recombinant human ultralente insulin in the morning and in the evening; the initial dose for each injection was 0.125 U per kilogram of body weight.
5825086|NCT00004984|Other|Close Observation|Study visits every 6 months including an oral glucose tolerance test
5825087|NCT00004984|Drug|Oral Insulin|Capsules oral insulin, 7.5 mg of recombinant human insulin crystals
5825088|NCT00004984|Drug|Placebo|Placebo for oral insulin
5825089|NCT00004983|Behavioral|diabetes self-management education|
5825090|NCT00004982|Drug|Combination Iron Chelation Therapy|
5825091|NCT00004980|Device|repetitive transcranial magnetic stimulation (rTMS)|a total of 132 minutes of stimulation at one hertz, motor threshold set at 80%, delivered to TP3 scalp site
5825092|NCT00004980|Device|sham stimulation|"132 minutes of stimulation given at 80% motor threshold with coil tilted single wing 45 degrees away from scalp deliverd to TP3 site"
5825093|NCT00004854|Drug|Carvedilol|
5825094|NCT00004853|Biological|Filgrastim|5 microgram/kg/dose SC daily starting 24-36 hours after last dose of chemotherapy until post-nadir ANC >=10,000/microliter
5825095|NCT00004853|Biological|Filgrastim-SD/01|100 microgram/kg SC 24-36 hours after last dose of chemotherapy (single dose)
5825096|NCT00004847|Drug|([18F]-DOPA)|is L 3, 4 dihydroxyphenylalanine (L-DOPA) labeled with the radioactive isotope 18F. In general, PPGLs belong to the group of neuroendocrine tumors. This heterogeneous group of tumors takes up amino acids, transforms them into biogenic amines (dopamine and serotonin) by decarboxylation and stores the amines in vesicles. L DOPA is a precursor of catecholamines (dopamine, norepinephrine and epinephrine). Epinephrine conversion to dopamine is catalyzed by the aromatic amino acid decarboxylase. According to previous and current studies, [18F]-DOPA PET is highly sensitive and specific for detection of PHEO /PGL67-69. However, there are only a few reports in the literature using [18F]-DOPA as a PET agent and particularly for patients with metastatic PPGLs. PET imaging will be done together with either a CT, an MRI or both modalities.
5825097|NCT00004847|Drug|[68Ga]-DOTATATE|is an imaging agent that binds specifically to somatostatin receptors (SSTRs). PPGLs similar to other neuroendocrine tumors express one or more SSTRs1-5. According to previous and current studies, [68Ga]-DOTATATE PET is highly sensitive and specific for the detection of PHEO/PGL and other neuroendocrine tumors.
5825098|NCT00004847|Drug|([18F]-6F-DA)|is an imaging agent developed at the NIH, that may improve specificity and sensitivity in the localization of PPGLs. [18F]-6F-DA enters cells via the membrane norepinephrine transporter. Once inside cells, [18F]-6F- DA is translocated via the vesicular monoamine transporter into storage vesicles, where the radioactivity is concentrated. After injection of [18F]-6F- DA, the much faster disappearance of [18F]-6F-DA-derived radioactivity from the bloodstream and non- neuronal cells than from chromaffin cells should enable rapid visualization of PPGLs by PET scanning.
5825099|NCT00004846|Drug|ABC/Gen-Probe/Chiron HIV-1/HCV 001|
5825100|NCT00004739|Drug|Antiretroviral therapy|
5825101|NCT00004845|Drug|Rofecoxib|
5825102|NCT00004845|Drug|Naproxen|
5825103|NCT00004734|Drug|pyridoxine|
5825104|NCT00004734|Drug|cyanocobalamin|
5825105|NCT00004734|Drug|folic acid multivitamin|
5825106|NCT00004733|Drug|levodopa|
5825107|NCT00004732|Procedure|Carotid Endarterectomy (CEA)|CEA involves a neck incision and physical removal of the plaque from the inside of the carotid artery.
5825108|NCT00004732|Device|Carotid Artery Stenting (CAS)|CAS involves insertion of a catheter or tube into an artery in the groin and then threading the catheter through the arteries of the body to the location of the plaque within the carotid artery in the neck. A stent is then placed to cover the plaque and hold the artery open. Participants randomized to this arm of the trial were treated using the RX Acculink Carotid Stent with or without the RX Accunet Embolic Protection Device.
5825109|NCT00004731|Drug|Coenzyme Q10|
5825110|NCT00004730|Drug|magnesium sulfate|
5825111|NCT00004729|Behavioral|Ketogenic diet|
5825112|NCT00004728|Drug|Warfarin|
5825113|NCT00004728|Drug|Aspirin|
5825114|NCT00004727|Drug|aspirin|
5825115|NCT00004727|Drug|ticlopidine|
5825116|NCT00004941|Drug|monoclonal antibody cA2|
5825117|NCT00004940|Drug|cysteine hydrochloride|
5825118|NCT00004939|Drug|,4-diaminopyridine|
5825119|NCT00004938|Drug|fluconazole|
5825120|NCT00004844|Procedure|tissue implantation|
5825121|NCT00004843|Procedure|parathyroidectomy|Standard parathyroidectomy with a bilateral approach
5825122|NCT00004843|Other|Observation|Usual care
5825123|NCT00004842|Drug|budesonide|Oral budesonide, 9 mg daily was administered for 1 year
5825124|NCT00004840|Drug|thyrotropin-releasing hormone|
5825125|NCT00004838|Drug|succimer|
5825126|NCT00004834|Drug|imipramine|
5825127|NCT00004834|Behavioral|cognitive-behavioral therapy|
5825128|NCT00004833|Drug|Immune globulin|
5825129|NCT00004832|Drug|3,4-diaminopyridine|
5825130|NCT00004831|Drug|cysteine hydrochloride|
5825131|NCT00004829|Drug|tobramycin|
5825132|NCT00004828|Drug|liothyronine I 131|
5825133|NCT00004827|Drug|docosahexaenoic acid|
5825134|NCT00004826|Drug|clozapine|
5825135|NCT00004825|Drug|recombinant human insulin-like growth factor I|
5825136|NCT00004817|Drug|phenytoin|
5825137|NCT00004817|Drug|valproate sodium|
5825138|NCT00004816|Drug|monoclonal antibody M-T412|
5825139|NCT00004815|Drug|growth hormone|
5825140|NCT00004814|Drug|copolymer 1|
5825141|NCT00004812|Behavioral|Exercise|
5825142|NCT00004811|Drug|itraconazole|
5825143|NCT00004810|Drug|-aminosalicylic acid|
5825144|NCT00004809|Procedure|gene therapy|
5825145|NCT00004808|Drug|fluconazole|
5825146|NCT00004807|Drug|dextromethorphan|
5825147|NCT00004807|Drug|topiramate|
5825148|NCT00004807|Drug|Donepezil|
5825149|NCT00004806|Genetic|Cystic fibrosis transmembrane conductance regulator|
5825150|NCT00004805|Behavioral|CPR instruction|
5825151|NCT00004804|Drug|interferon alfa|
5825152|NCT00004802|Drug|dichlorphenamide|
5825153|NCT00004801|Drug|monoclonal factor IX replacement therapy|
5825154|NCT00004800|Biological|diphtheria-tetanus-pertussis vaccine containing whole-cell pertussis|
5825155|NCT00004800|Biological|diphtheria-tetanus vaccine|
5825156|NCT00004799|Biological|whole-cell pertussis vaccine|
5825157|NCT00004799|Biological|diphtheria-tetanus vaccine|
5825158|NCT00004797|Drug|fructose|
5825159|NCT00004797|Drug|placebo|
5825160|NCT00004796|Drug|lactulose|
5825161|NCT00004795|Drug|dehydroepiandrosterone|
5825162|NCT00004794|Drug|cidofovir|
5825163|NCT00004789|Drug|heme arginate|
5825164|NCT00004789|Drug|tin mesoporphyrin|
5825165|NCT00004787|Drug|filgrastim|
5825166|NCT00004786|Drug|iloprost|
5825167|NCT00004785|Drug|dexamethasone|
5825168|NCT00004785|Drug|methylprednisolone|
5825169|NCT00004784|Drug|methotrexate|
5825170|NCT00004784|Drug|ursodiol|
5825171|NCT00004779|Genetic|Ad5-CB-CFTR|
5825172|NCT00004778|Drug|betamethasone|
5825173|NCT00004778|Drug|dexamethasone|
5825174|NCT00004778|Drug|thyrotropin-releasing hormone|
5825175|NCT00004776|Drug|topiramate|
5825176|NCT00004772|Drug|Immune globulin|
5825177|NCT00004771|Drug|leuprolide|
5825178|NCT00004771|Drug|testosterone|
5825179|NCT00004770|Drug|thioctic acid|
5825180|NCT00004767|Drug|Sodium Benzoate|
5825181|NCT00004767|Drug|Sodium Phenylacetate|
5825182|NCT00004767|Drug|Sodium Phenylbutyrate|
5825183|NCT00004767|Behavioral|Dietary Intervention|
5825184|NCT00004763|Drug|leuprolide|
5825185|NCT00004763|Drug|Ethinyl estradiol/norethindrone|
5825186|NCT00004762|Drug|cladribine|
5825187|NCT00004760|Behavioral|Exercise|
5825188|NCT00004759|Drug|methylprednisolone|
5825189|NCT00004759|Drug|tirilazad|
5825190|NCT00004758|Drug|carbamazepine|
5825191|NCT00004758|Drug|corticotropin|
5825192|NCT00004758|Drug|nitrazepam|
5825193|NCT00004758|Drug|pyridoxine|
5825194|NCT00004758|Drug|valproic acid|
5825195|NCT00004758|Procedure|Surgery|
5825196|NCT00004757|Drug|acyclovir|
5825197|NCT00004756|Procedure|Tailored educational program|
5825198|NCT00004756|Procedure|Educational materials|
5825199|NCT00004755|Drug|allopurinol|
5825200|NCT00004755|Drug|glucantime|
5825201|NCT00004754|Drug|epoprostenol|
5825202|NCT00004751|Procedure|Surgery|
5825203|NCT00004751|Procedure|Physical therapy|
5825204|NCT00004748|Drug|colchicine|
5825205|NCT00004748|Drug|methotrexate|
5825206|NCT00004748|Drug|ursodiol|
5825207|NCT00004747|Drug|mucoid exopolysaccharide P. aeruginosa immune globulin IV|
5825208|NCT00004744|Drug|immune globulin|
5825209|NCT00004740|Drug|isoniazid|
5825210|NCT00004705|Drug|amiloride|
5825211|NCT00004705|Drug|uridine|
5825212|NCT00004700|Drug|insulin-like growth factor I|
5825213|NCT00004699|Drug|insulin-like growth factor I|
5825214|NCT00004697|Drug|choline chloride|
5825215|NCT00004696|Drug|morphine|
5825216|NCT00004695|Drug|PEG-interleukin-2|
5825217|NCT00004694|Drug|heparin|
5825218|NCT00004690|Drug|monolaurin cream|
5825219|NCT00004689|Drug|amithiozone|
5825220|NCT00004689|Drug|clarithromycin|
5825221|NCT00004689|Drug|ethambutol|
5825222|NCT00004689|Drug|rifampin|
5825223|NCT00004689|Drug|streptomycin|
5825224|NCT00004688|Drug|carmustine|
5825225|NCT00004688|Drug|mercaptopurine|
5825226|NCT00004688|Drug|streptozocin|
5825227|NCT00004686|Drug|methotrexate|
5825228|NCT00004686|Drug|prednisone|
5825229|NCT00004685|Drug|albuterol|
5825230|NCT00004682|Drug|immune globulin|
5825231|NCT00004670|Procedure|pallidotomy|
5825232|NCT00004669|Drug|hydrocortisone|
5825233|NCT00004667|Drug|von Willebrand factor|
5825234|NCT00004665|Drug|dehydroepiandrosterone|
5825235|NCT00004664|Drug|megestrol|
5825236|NCT00004664|Behavioral|Exercise|
5825237|NCT00004662|Drug|dehydroepiandrosterone|
5825238|NCT00004660|Radiation|Radiotherapy|
5825239|NCT00004660|Radiation|Sham treatment|
5825240|NCT00004659|Procedure|irradiation|
5825241|NCT00004659|Procedure|radiosurgery|
5825242|NCT00004658|Drug|ribose|
5825243|NCT00004658|Drug|thymidine|
5825245|NCT00004656|Procedure|Metabolic assessment with body composition evaluation|
5825246|NCT00004654|Drug|soy protein isolate|
5825247|NCT00004652|Drug|pimozide|
5825248|NCT00004650|Drug|conjugated estrogens|
5825249|NCT00004650|Drug|Medroxyprogesterone|
5825250|NCT00004647|Drug|mexiletine|
5825251|NCT00004646|Drug|prednisone|
5825252|NCT00004645|Procedure|Plasma exchange|
5825253|NCT00004644|Drug|acyclovir|
5825254|NCT00004643|Drug|cytarabine|
5825255|NCT00004642|Drug|SDZ MSL-109|
5825256|NCT00004638|Procedure|pathogenesis study|
5825257|NCT00004637|Drug|Vitamin E|
5825258|NCT00004635|Drug|Thalidomide|Thalidomide 200 mg given orally every evening at 9pm. Treatment may continue indefinitely provided that there are no dose-limiting toxicity.
5825259|NCT00004635|Drug|leuprolide acetate|Injections of leuprolide once a month for six months.
5825260|NCT00004635|Drug|goserelin|Injections of Goserelin once a month for six months.
5825261|NCT00004635|Other|Placebo|Patients will receive the placebo if they initially received thalidomide. The starting dose of placebo 200 mg (four capsules of 100-50 mg capsules) orally once daily at bedtime.
5825262|NCT00004573|Drug|ganciclovir|
5825263|NCT00004572|Procedure|Sustacal challenge|
5825264|NCT00004569|Procedure|Non-invasive technique to diagnose and quantitate sleep-disordered breathing|
5825265|NCT00004567|Drug|Mycophenolate Mofetil|
5825266|NCT00004564|Drug|Clopidogrel|
5825267|NCT00004564|Drug|Atorvastatin|
5825268|NCT00004563|Drug|Cyclophosphamide|Cyclophosphamide (Cytoxan, Bristol-Myers Squibb) was initiated with a dose of 1 mg per kilogram of body weight per day (to the nearest 25 mg). The doses were increased monthly by one capsule up to 2 mg per kilogram.
5825269|NCT00004563|Drug|Placebo|Matching gelcaps 25 mgs
5825270|NCT00004562|Drug|Beta adrenergic blockers|Participants will receive beta adrenergic blockers.
5825271|NCT00004562|Drug|Platelet inhibitors|Participants will receive platelet inhibitors.
5825272|NCT00004562|Procedure|PTCA and stents|Participants will undergo percutaneous coronary intervention (PTCA) and coronary stenting.
5825273|NCT00004562|Drug|ACE Inhibitors|Participants will receive ACE inhibitors.
5825274|NCT00004561|Behavioral|exercise|
5825275|NCT00004560|Device|defibrillator|
5825276|NCT00004559|Behavioral|dietary polyunsaturated fatty acid|
5825277|NCT00004558|Behavioral|dietary n-3 polyunsaturated fatty acids|
5825278|NCT00004554|Drug|naltrexone (Revia)|100mg/day
5825279|NCT00004554|Drug|sertraline (Zoloft)|200mg/day
5825280|NCT00004554|Drug|Placebo|Placebo
5825281|NCT00004553|Procedure|Electromyography|
5825282|NCT00004552|Drug|acamprosate (Campral)|
5825283|NCT00004551|Drug|nicotine replacement patch|
5825284|NCT00004551|Behavioral|mood management|
5825285|NCT00004549|Procedure|Magnetic resonance imaging|
5825286|NCT00004547|Procedure|Surgery|Patients will undergo cytoreductive surgery to remove as much tumor as possible. Part of the intestines, pancreas, stomach or the entire spleen may also be removed if they are affected.
5825287|NCT00004547|Procedure|Continuous hyperthermic peritoneal perfusion (CHPP) with Cisplatin|
5825288|NCT00004547|Drug|Postoperative dwell with paclitaxel and 5-FU|Intraperitoneal dwell chemotherapy with a combination of 5-FU and Paclitaxel will be delivered in the early postoperative period (day 7 today 12 after surgery). Patients will be premedicated with hydrocortisone (100 mg/intravenous push (i.v.p.)), diphenhydramine (50 mg i.v.p.) and ranitidine (50 mg i.v.p.) 30 minutes prior to delivering intraperitoneal chemotherapy. One liter of normal saline will be infused containing 5-FU (800 mg/M^2) and 1 L of normal saline containing paclitaxel (125 mg/M^2) will be infused over 60 minutes. The chemotherapy solution will be left in the abdominal cavity permanently for slow absorption.
5825289|NCT00004533|Drug|Adeno-associated virus-CFTR vector|
5825290|NCT00000436|Behavioral|Self-efficacy and muscle strength training|
5825291|NCT00000436|Procedure|High-intensity strength training|
5825292|NCT00001984|Drug|Alemtuzumab and DSG|Alemtuzumab was administered intravenously at 0.3 mg/kg/dose over 3 hr. Patients received one dose on each of days -1,+1,+3 and +5 relative to transplantation (total dose 1.2 mg/kg). Methylprednisolone was given prior to each dose to limit the cytokine release: 500 mg prior to dose 1, 125 mg prior to dose 2, and 60 mg prior to doses 3 and 4. Deoxyspergualin was dosed as follows. The first two patients received 4 mg/kg as a loading dose on the day of transplant and 2.5 mg/kg daily for 13 additional days (14 days of treatment; 36.5 mg/kg total dose). The next three patients received the same dosing regimen but it was initiated on postoperative day 12 to coincide with the resurgence of monocytes on days 12- 25.
5825293|NCT00000435|Drug|dnaJ peptide|dnaJP1 was taken in pill form at 25mg/day for 6 months
5825294|NCT00000435|Drug|None-placebo|placebo was taken in pill form at 25mg/day for 6 months
5825295|NCT00000434|Behavioral|Fit and Strong!|Fit and Strong! is a multi-component exercise and health education program that includes flexibility, aerobic conditioning, strength training, and group discussion/problem solving for lifestyle change.
5825296|NCT00001972|Drug|15 O Water|
5825297|NCT00001967|Drug|HAART|
5825298|NCT00001964|Drug|Cyclosporine A|Cyclosporine A
5825299|NCT00001964|Drug|ATG|ATG
5825300|NCT00001964|Drug|MMF|MMF
5825301|NCT00001962|Drug|Daclizumab|Daclizumab, 1mg/kg of body weight, every 2 weeks for a total of 5 infusions.
5825302|NCT00001961|Procedure|MRI|
5825303|NCT00001960|Device|Pacemaker therapy|
5825304|NCT00001959|Drug|Pirfenidone|During the study drug period of 12 months, patients will receive oral pirfenidone daily. For patients whose initial renal function is 50-80 ml/min as assessed by the MDRD equation, the initial pirfenidone dosage will be calculated at 40 mg/kg/d, with a maximum dose of 800 mg TID. For patients whose initial renal function is 30-50 ml/min, the initial dose will be 30 mg/kg/d. For patients whose initial renal function is between 15 and 30 ml/min, the initial dose will be 20 mg/kg/d.
5825305|NCT00001958|Drug|Hydroxyurea|
5825306|NCT00001956|Procedure|Blood draw|
5825307|NCT00001956|Procedure|Oral surgery|
5825308|NCT00001956|Procedure|Tissue biopsy|
5825309|NCT00001955|Drug|Etanercept|
5825313|NCT00001946|Procedure|Magnetic resonance angiography|
5825314|NCT00001941|Biological|daclizumab|
5825315|NCT00000433|Drug|Anti-Tumor Necrosis Factor|
5825316|NCT00000432|Behavioral|Education about disease prevention|
5825317|NCT00000431|Drug|PDGF-B/Ad5|This is a dose finding study to evaluate the safety of a single injection of PDGF dna in an adenoviral vector.
5825318|NCT00000430|Drug|Alendronate|
5825319|NCT00000430|Drug|Estrogen/progestin therapy|
5825320|NCT00000429|Drug|Calcium carbonate|
5825321|NCT00000428|Drug|Amitriptyline|Amitriptyline 25 mg po
5825322|NCT00000428|Drug|Amitriptyline plus Fluoxitine|Amitriptyline 25 mg po plus Fluoxitine 20 mg po
5825323|NCT00000427|Drug|Parathyroid hormone|
5825324|NCT00000427|Drug|Alendronate|
5825325|NCT00000111|Procedure|Oral mucosal graft|
5825326|NCT00000110|Procedure|magnetic resonance spectroscopy|
5825327|NCT00000110|Drug|dietary fat|
5825328|NCT00000108|Behavioral|Exercise|
5825329|NCT00000106|Device|Whole body hyperthermia unit|
5825330|NCT00000393|Drug|Peptide T|
5825331|NCT00000392|Drug|Peptide T|
5825332|NCT00000392|Drug|Placebo|
5825333|NCT00000391|Drug|Peptide T|
5825334|NCT00000390|Drug|Imipramine hydrochloride|
5825335|NCT00001934|Drug|Zenapax|
5825336|NCT00001933|Drug|Nefiracetam|
5825337|NCT00001926|Drug|O15|
5825338|NCT00001926|Device|Cadwell rTMS|
5825339|NCT00001925|Drug|Alcohol|
5825340|NCT00001923|Procedure|Transcranial magnetic stimulation|
5825341|NCT00001919|Drug|Hypericum (LI-160)|
5825342|NCT00001917|Drug|O15|
5825343|NCT00001917|Drug|[F-18] FP-TZTP|
5825344|NCT00001911|Drug|Interleukin-12|
5825345|NCT00001905|Drug|Interferon gamma|
5825346|NCT00001901|Drug|Etanercept|
5825347|NCT00001895|Drug|FDG|
5825348|NCT00001895|Drug|NH(3)|
5825349|NCT00001894|Procedure|pacemaker implantation|
5825350|NCT00001894|Procedure|percutaneous transluminal septal ablation (PTSA)|
5825351|NCT00001893|Drug|TNFR:Fc|
5825352|NCT00001880|Drug|methotrexate|CSA beginning day -4 and intravenous MTX on days +1, +3, and +6 will be given
5825353|NCT00001880|Drug|cyclosporin|CSA beginning day -4 and intravenous MTX on days +1, +3, and +6 will be given
5825354|NCT00001877|Drug|Pentoxifylline|
5825355|NCT00001873|Device|Isolex 300i plus MoAbs|
5825356|NCT00001870|Drug|Acetylcholine|
5825357|NCT00001865|Drug|Daclizumab|
5825358|NCT00001863|Drug|Leflunomide|
5825359|NCT00001862|Drug|Enbrel|
5825360|NCT00001860|Drug|Sandostatin LAR Depot versus transsphenoidal surgery|
5825361|NCT00001854|Drug|Ribavirin|
5825362|NCT00001849|Drug|Pentetreotide|Binds primarily to the somatostatin receptors subtypes (sst) 2 and 5
5825363|NCT00001849|Drug|18F-DOPA|F-DOPA is a radiolabeled amino acid used as a radiotracer in positron emission tomography.
5825364|NCT00001848|Drug|Raloxifene|
5825365|NCT00001842|Drug|Granulocyte colony-stimulating factor|
5825366|NCT00001842|Drug|Dexamethasone|
5825367|NCT00001835|Drug|Oxaliplatin|
5825368|NCT00001832|Drug|gp100:209-217 (210M)|"gp100 = gp100:209‑217(210M) peptide - 1 mg in IFA SQ (in the subcutaneous tissue of each thigh) on the morning of the cell infusion, plus gp100:209‑217(210M) peptide, 1 mg, in IFA injected into the subcutaneous tissue in two equal volumes, 1.0 mL for each injection, within 2cm of each other, in the thigh daily for five days starting on the morning of the cell infusion and then weekly for 3 more injections.~MART-1 = MART‑1:26‑35(27L) peptide- 1 mg in IFA SQ (in the subcutaneous tissue of each thigh) on the morning of the cell infusion, plus MART‑1:26‑35(27L) peptide, 1 mg, in IFA injected into the subcutaneous tissue in two equal volumes, 1.0 mL for each injection, within 2cm of each other, in the thigh daily for five days starting on the morning of the cell infusion and then weekly for 3 more injections."
5825369|NCT00001832|Drug|Montanide ISA-51|MART-1 = MART‑1:26‑35(27L) peptide- 1 mg in IFA SQ (in the subcutaneous tissue of each thigh) on the morning of the cell infusion, plus MART‑1:26‑35(27L) peptide, 1 mg, in IFA injected into the subcutaneous tissue in two equal volumes, 1.0 mL for each injection, within 2cm of each other, in the thigh daily for five days starting on the morning of the cell infusion and then weekly for 3 more injections.
5825370|NCT00001832|Drug|IL-2|"125,000 IU/kg dose intravenous for 5 days for 6 weeks with 2 days rest per week.~720,000 IU/kg intravenous every 8 hours for a maximum of 12 doses."
5825371|NCT00001832|Drug|MART-1:26-35(27L)|MART-1 = MART‑1:26‑35(27L) peptide- 1 mg in IFA SQ (in the subcutaneous tissue of each thigh) on the morning of the cell infusion, plus MART‑1:26‑35(27L) peptide, 1 mg, in IFA injected into the subcutaneous tissue in two equal volumes, 1.0 mL for each injection, within 2cm of each other, in the thigh daily for five days starting on the morning of the cell infusion and then weekly for 3 more injections.
5825372|NCT00001832|Biological|Abl cells|Abl cells IV = Lymphocytes 10^9‑10^11 IV over 30 minutes on day 0, repeated in 14 to 21 days Abl cells IA = Lymphocytes 10^9‑10^11 IA over 30 minutes on day 0, repeated in 14 to 21 days
5825373|NCT00001832|Drug|Fludarabine|5x25 mg/m^2 intravenous
5825374|NCT00001832|Drug|Cyclophosphamide|2x30 mg/kg, 2x60 mg/kg intravenous
5825375|NCT00001832|Biological|GCSF (Growth colony stimulating factor)|Beginning on day 1 or 2, GCSF will be administered subcutaneously at a dose of 5mcg/kg/day (not to exceed 300 mcg/day. Filgrastim administration will continue daily until neutrophil count > 1.0 x10^9/L x 3 days or > 5.0 x10^9/L.
5825376|NCT00001832|Procedure|Apheresis|
5825377|NCT00001830|Drug|Th2 cells in allo HSCTT|
5825378|NCT00001830|Drug|Th2 Cells|
5825379|NCT00001827|Biological|aldesleukin|
5825380|NCT00001827|Biological|incomplete Freund's adjuvant|
5825381|NCT00001827|Biological|p53 peptide vaccine|
5825382|NCT00001827|Biological|sargramostim|
5825383|NCT00001827|Biological|therapeutic autologous dendritic cells|
5825384|NCT00001827|Procedure|in vitro-treated peripheral blood stem cell transplantation|
5825385|NCT00001806|Other|Genetic Education and Counseling|Group Education and Counseling
5825386|NCT00001806|Other|Genetic Education and Counseling|Individual Education and Counlseing
5825387|NCT00001785|Drug|Recombinant human interferon beta-1a|
5825388|NCT00001784|Drug|Mexiletine|
5825389|NCT00001783|Drug|0-15 Water|
5825390|NCT00001781|Drug|CGP 77116|
5825391|NCT00001776|Device|Cadwell Rapid Rate Magnetic Stimulator|
5825392|NCT00001766|Drug|Amprenavir, Efavirenz, Abacavir, Nelfinavir, Ritonavir|
5825393|NCT00001765|Device|Nexell Isolex with T-cell Depletion|
5825394|NCT00001765|Device|Baxter isolex 300i|
5825395|NCT00001764|Drug|Mycophenolate Mofetil|
5825396|NCT00001758|Drug|Abacavir|
5825397|NCT00001758|Drug|Amprenavir|
5825398|NCT00001758|Drug|Efavirenz|
5825399|NCT00001750|Drug|Stemgen|
5825400|NCT00001749|Drug|Antithymocyte globulin|
5825401|NCT00001749|Drug|Cyclosporine|
5825402|NCT00001741|Drug|Losartan|
5825403|NCT00001737|Drug|Cyclosporin A Implant|
5825404|NCT00001729|Drug|Ribavirin|
5825405|NCT00001728|Drug|Fosamax (Alendronate)|
5825406|NCT00001725|Drug|Dextromethorphan|
5825407|NCT00001724|Drug|Flurbiprofen|
5825408|NCT00001723|Drug|Orlistat|Subjects receive drug for 6 months plus a 12 week intensive behavioral weight los program. Subjects return for monthly visits for 3 more months.
5825409|NCT00001723|Drug|Placebo|Subjects receive drug for 6 months plus a 12 week intensive behavioral weight los program. Subjects return for monthly visits for 3 more months.
5825410|NCT00001720|Drug|Alendronate|
5825411|NCT00001716|Drug|Nitric Oxide|
5825412|NCT00001716|Drug|Nitroglycerin|
5825413|NCT00001713|Drug|Recombinant Tissue Plasminogen Activator|
5825414|NCT00001713|Drug|Heparin|
5825415|NCT00001713|Drug|Warfarin|
5825416|NCT00001703|Biological|incomplete Freund's adjuvant|0.7 ml of ISA-51 (Montanide ISA-51 adjuvant, incomplete Freund's adjuvant) will be mixed with peptide alone and injected subcutaneously every four weeks for a total of four vaccinations.
5825417|NCT00001703|Biological|von Hippel-Lindau peptide vaccine|1000 micrograms administered subcutaneously every four weeks for a total of four vaccinations.
5825418|NCT00001698|Drug|Ketorolac Rinse|
5825419|NCT00001693|Drug|Celecoxib (SC-58635)|
5825420|NCT00001689|Drug|Vincristine|
5825421|NCT00001683|Drug|COL-3|
5825422|NCT00001676|Drug|SQ Fludarabine|
5825423|NCT00001666|Device|Cadwell High-Speed Magnetoelectric Stimulator|
5825424|NCT00001666|Device|Magpro High-Speed Magnetoelectric Stimulator|
5825425|NCT00001663|Device|Magstim Super Rapid Stimulator|
5825426|NCT00001662|Drug|CX516 (Ampalex)|
5825427|NCT00001656|Drug|Olanzapine|tablet; 5-20mg/day; 8 weeks
5825428|NCT00001656|Drug|Clozapine|tablet; 12.5-900mg/day; 8 weeks
5825429|NCT00001651|Other|[6,6-2H2]-glucose|[6,6-2H2]-glucose will be administered as a continuous IV infusion for one to five days.
5825430|NCT00001649|Drug|Valaciclovir|
5825431|NCT00001647|Procedure|White blood cell infusion|
5825432|NCT00001644|Drug|Indinavir|
5825433|NCT00001644|Drug|Zidovudine|
5825434|NCT00001644|Drug|Lamivudine|
5825435|NCT00001644|Drug|Nevirapine|
5825436|NCT00001644|Procedure|Blood testing|
5825437|NCT00001644|Procedure|Lymph node biospy|
5825438|NCT00001644|Procedure|Leukapheresis|
5825439|NCT00001637|Procedure|Blood cell transplantation|
5825440|NCT00001631|Procedure|Magnetic resonance imaging|
5825441|NCT00001630|Device|Isolex 300i|
5825442|NCT00001626|Drug|antithymocyte globulin|antithymocyte globulin
5825443|NCT00001626|Drug|cyclophosphamide|cyclophosphamide
5825444|NCT00001626|Drug|cyclosporine|cyclosporine
5825445|NCT00001623|Procedure|Allogeneic Bone Marrow Transplant|
5825446|NCT00001601|Procedure|Electrocardiogram|
5825447|NCT00001601|Procedure|Biopsies|
5825448|NCT00001601|Procedure|Diagnostic imaging|
5825449|NCT00001599|Drug|Thalidomide|
5825450|NCT00001598|Drug|Dehydroepiandrosterone|
5825451|NCT00001596|Drug|Pirfenidone|Treatment with pirfenidone 801 mg (3 pills of 267 mg each), three times daily.
5825452|NCT00001596|Drug|Placebo|Placebo (3 pills), three times daily.
5825453|NCT00001586|Biological|Rituximab|Rituxan
5825454|NCT00001586|Drug|Fludarabine phosphate|Fludara
5825455|NCT00001586|Other|Leukemic or stroma cells|Patients are eligible to donate cells for the purpose of analyzing leukemic cells. Cells can be donated by apheresis (e.g. 60-90 minute intravenous technique), lymph node biopsy (e.g. 3 biopsy/excision of lymph nodes)bone marrow biopsy (e.g. 2-4 separate bone marrow biopsies), and bone marrow aspiration (e.g. 3 to 5cc of marrow per aspirate).
5825456|NCT00001576|Drug|Melphalan|
5825457|NCT00001576|Drug|Floxuridine|
5825458|NCT00001576|Drug|Leucovorin|
5825459|NCT00001575|Biological|Y-90 Humanized Anti-Tac|10 mCi (if a bone marrow transplant was part of the patient's previous therapy) or 15 mCi of yttrium labeled anti-TAC; followed by calcium trisodium Inj (Ca DTPA).
5825460|NCT00001575|Drug|Calcium-DTPA|Ca-DTPA will be administered intravenously on Days 1-3 to clear the radioactive agent from the body
5825461|NCT00001572|Drug|Id-KLH Vaccine|
5825462|NCT00001572|Drug|QS-21 (Stimulation-QS-21) Drug|
5825463|NCT00001569|Drug|Cisplatin|
5825464|NCT00001569|Drug|Paclitaxel|
5825465|NCT00001569|Drug|5-FU|
5825466|NCT00001568|Drug|2-Fluoro-2-deoxyglucose|
5825467|NCT00001567|Drug|Roferon-A|
5825468|NCT00001566|Biological|therapeutic autologous dendritic cells|3 syringes containing 1 x 10^6peptide pulsed dendritic cells
5825469|NCT00001566|Drug|indinavir sulfate|Oral dose, 350 mg/m^2 administered every 8 hours. Maximum dose is 800 mg every 8 hours.
5825470|NCT00001566|Procedure|peripheral blood stem cell transplantation|Harvested autologous T cells, minimum dose 1 x 10^6/kg will be thawed rapidly in 37 degree water bath and infused sequentially over 5-15 minutes.
5825471|NCT00001564|Drug|EF-1 Peptide|
5825472|NCT00001564|Drug|EF-2 Peptide|
5825479|NCT00001563|Biological|Filgrastim|Filgrastim after EPOCH-R from Day 6 for 10 days every cycle.
5825480|NCT00001563|Biological|Rituximab|EPOCH-R every 3 weeks for up to 6 cycle
5825481|NCT00001563|Drug|EPOCH|EPOCH-R every 3 weeks for up to 6 cycle
5825482|NCT00001561|Drug|Myeloma Immunoglobulin Idiotype Vaccine-KLH|
5825483|NCT00001561|Drug|GM-CSF|
5825484|NCT00001550|Drug|IVIg|
5825485|NCT00001545|Device|Magstim Super Rapid Magnetic Stimulator|
5825486|NCT00001545|Device|Cadwell MES-10|
5825487|NCT00001535|Drug|Syngeneic Lymphocytes (CD4+) Cultured with OKT3 (Ortho) and Interleukin-2 (Chiro|
5825488|NCT00001534|Drug|Losartan|
5825489|NCT00001532|Device|Toshibia Aquilion ONE CT|The Toshiba Aquilion ONE CT system is currently being used for studies in both general CT radiology and CT cardiac imaging. One of the unique aspects of the Aquilion ONE CT system is its ability to acquire whole organ volume images in a single rotation by utilizing an x-ray detector that is configured as 320 detector rows with a 0.5 mm width, providing a z-axis coverage of 16 cm of anatomy. In line with the evolutionary changes to CT systems, the Aquilion ONE will be upgraded with new technology that will expand its capabilities. The changes being made to the Aquilion ONE will provide enhancements to image acquisition capabilities, reduce ionizing radiation dose, and improve subject access to the system. All of these features assist in enhancing the safety of the currently installed Aquilion ONE CT system.
5825490|NCT00001526|Drug|Daclizumab (Zenapax)|
5825491|NCT00001524|Drug|Thalidomide|
5825492|NCT00001521|Drug|Flutamide|Non steroidal antiandrogen that prevents the action of androgens by blocking receptor sites in target tissue. It may also produce changes in testosterone and estradiol
5825493|NCT00001521|Drug|Letrozole|Armomatase inhibitor.
5825494|NCT00001515|Device|virtual bronchoscopy|
5825495|NCT00001512|Drug|Id-KLH Vaccine|
5825496|NCT00001512|Drug|GM-CSF|
5825497|NCT00001507|Drug|Monoclonal Antibody 3A1|
5825498|NCT00001507|Drug|Monoclonal Antibody 95-5-49|
5825499|NCT00001507|Drug|Monoclonal Antibody 95-6-22|
5825500|NCT00001507|Device|Baxter Isolex 3001 Stem Cell Selection System|
5825501|NCT00001507|Device|Ceprate SC|
5825502|NCT00001504|Drug|9-cis-Retinoic Acid|
5825503|NCT00001487|Drug|Dehydroepiandrosterone|
5825504|NCT00001483|Drug|buproprion (Wellbutrin)|
5825505|NCT00001483|Drug|sertraline (Zoloft)|
5825506|NCT00001483|Drug|venlafaxine (Effexor)|
5825507|NCT00001481|Drug|Estradiol, Progesterone, Placebo|To determine whether women who have had a previous episode of postpartum major affective episode will experience differential mood and behavioral effects compared with controls.
5825508|NCT00001476|Drug|Gene Therapy Method for CGD|
5825509|NCT00001476|Device|Isolex 300i Magnetic Cell Selector|
5825510|NCT00001475|Drug|IL-2 plus Anti-TNF or Thalidomide|
5825511|NCT00001474|Drug|Interleukin-2|
5825512|NCT00001465|Device|Toshibia Aquilion One CT|The Toshiba Aquilion ONE CT system is currently being used for studies in both general CT radiology and CT cardiac imaging. One of the unique aspects of the Aquilion ONE CT system is its ability to acquire whole organ volume images in a single rotation by utilizing an x-ray detector that is configured as 320 detector rows with a 0.5 mm width, providing a z-axis coverage of 16 cm of anatomy. In line with the evolutionary changes to CT systems, the Aquilion ONE will be upgraded with new technology that will expand its capabilities. The changes being made to the Aquilion ONE will provide enhancements to image acquisition capabilities, reduce ionizing radiation dose, and improve subject access to the system. All of these features assist in enhancing the safety of the currently installed Aquilion ONE CT system.
5825513|NCT00001460|Behavioral|inpatient evaluation and management|
5825514|NCT00001457|Drug|Lamivudine|
5825515|NCT00001444|Drug|7-hydroxystaurosporine (UCN-01)|
5825516|NCT00001442|Drug|paclitaxel concurrent with radiation therapy|
5825517|NCT00001440|Procedure|Autologous T cells|
5825518|NCT00001440|Drug|Interleukin-2|
5825519|NCT00001430|Procedure|PBSC|
5825520|NCT00001430|Drug|IL-2|
5825521|NCT00001430|Drug|EPOCH II|
5825522|NCT00001426|Drug|Cyclophosphamide|
5825523|NCT00001426|Drug|Paclitaxel|
5825524|NCT00001426|Drug|Cisplatin|
5825525|NCT00001426|Drug|G-CSF|
5825526|NCT00001410|Drug|Lysodase|
5825527|NCT00001409|Drug|Interleukin-2|
5825528|NCT00001407|Drug|Interferon Gamma|
5825529|NCT00001399|Drug|Transduced CD34+ Cells|
5825530|NCT00001398|Drug|Recombinant Methionyl Human Stem Cell Factor (r-metHuSCF)|
5825531|NCT00001396|Device|Paragon Pacemaker|
5825532|NCT00001386|Drug|PCLUS 3-18 MN|
5825533|NCT00001386|Drug|PCLUS 6.1 MN|
5825534|NCT00001379|Biological|Interferon|For LYG Grade 1 and 2: Interferon starting at 7.5 million Units subQ 3 times a week and increasing on the following schedule: 10 million U; 15 million U; 20 million U; 25 million U; and increased in 5 million U increments, as tolerated. Patients continue taking interferon for 1 year beyond CR.
5825535|NCT00001379|Drug|Rituxan and EPOCH|For LYG Grade 3: EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, rituxan) every 3 weeks for 6 cycles.
5825536|NCT00001368|Procedure|cytokine and leukocyte activation profile|
5825537|NCT00001359|Drug|Penicillin or Placebo|
5825538|NCT00001357|Drug|Interleukin-2|
5825539|NCT00001354|Drug|Interleukin-2/Zidovudine (AZT)|
5825540|NCT00001353|Drug|Genetically Marked Syngeneic T Lymphocytes|
5825541|NCT00001343|Drug|Humatrope|
5825542|NCT00001343|Drug|Oxandrolone|
5825543|NCT00001339|Drug|doxorubicin, vincristine, and etoposide with mitotane|
5825544|NCT00001337|Drug|EPOCH|Combination chemotherapy given with Rituximab (EPOCH-R) IV every 3 weeks for 6 cycles.
5825545|NCT00001337|Biological|Rituximab|Rituximab given on Day 1 of combination chemotherapy (EPOCH-R) every 3 weeks for 6 cycles.
5825546|NCT00001335|Drug|ADR-529|
5825547|NCT00001335|Drug|Topotecan|
5825548|NCT00001335|Drug|G-CSF|
5825549|NCT00001328|Drug|Cytovene (Ganciclovir Sodium)|
5825550|NCT00001328|Device|G1TKSVNa.53 Producer Cell Line|
5825552|NCT00001322|Drug|Leuprolide Acetate 3.75|Each woman will be administered Lupron for two months only.
5825553|NCT00001322|Drug|Estrogel|After the first month of Lupron treatment when ovarian suppression has been achieved, we will administer 2-3 applications (approximately 6.0 9.0 mg estradiol gel (open label)) once a day for four weeks.
5825554|NCT00001322|Drug|Progesterone|After the four weeks of estradiol treatment, all women will receive one week of progesterone suppositories (200 mg twice a day) to precipitate a progesterone withdrawal-induced menses.
5825555|NCT00001309|Other|Vitamin C|Outpatient subjects will be encouraged to consume vitamin C in foods. As inpatients, vitamin C deficiency will be induced by placing subjects on a tightly restricted scorbutic diet. Plasma vitamin C will be monitored several times per week. When subjects have achieved a plasma ascorbate concentration of 5-10 micromolar, blood sampling and urine collection over 24 hours will be performed. After platelets and leukocytes are collected, ascorbate repletion will begin. Escalating doses of ascorbate will be administered orally and intravenously for the remainder of their inpatient admission. Total daily doses of 30mg, 60mg, 100mg, 200mg, 400mg, 1000mg and 2500mg will be given in two divided doses. Bioavailability of ascorbate will be determined at each dosage increment. When plasma ascorbate concentration reaches steady state for each dose, subjects will undergo 36 hr plasma sampling and a timed 48 hr urine collection.
5825556|NCT00001307|Drug|Oxygen-15 Water|
5825557|NCT00001307|Drug|Capsaicin|
5825558|NCT00001305|Drug|Humatrope|Patients receive a subcutaneous injection.
5825559|NCT00001304|Drug|Synthetic Human Parathyroid Hormone 1-34|twice daily subcutaneous injections
5825560|NCT00001304|Drug|Calcitriol & Calcium|Twice daily oral calcitriol with 1000 mg Calcium carbonate supplementation
5825561|NCT00001303|Drug|Reference Endotoxin|
5825562|NCT00001303|Drug|Inhaled Nitric Oxide|
5825563|NCT00001302|Drug|PSC 833|
5825564|NCT00001288|Drug|15 O Water|
5825565|NCT00001288|Drug|FDG|
5825566|NCT00001282|Drug|Zidovudine (AZT) & Interleukin-2 (IL2)|
5825567|NCT00001266|Drug|Suramin|
5825568|NCT00001262|Drug|Copper Histidine|
5825569|NCT00001261|Drug|Gamma Globulin|
5825570|NCT00001259|Drug|Leuprolide|3.75mg IMQM
5825571|NCT00001259|Drug|Estradiol Patches|0.1 mg/day of estradiol via skin patch (Estraderm) for a period of five weeks.
5825572|NCT00001259|Drug|Progesterone|progesterone suppositories (200 mgs twice daily)
5825573|NCT00001256|Drug|prednisone and methotrexate|
5825574|NCT00001255|Drug|ADA PBSC|
5825575|NCT00001255|Drug|ADA Umbilical Cord Blood Cells|
5825576|NCT00001255|Drug|Transduced Lymphocytes|
5825577|NCT00001253|Behavioral|cognitive tests and scales|
5825578|NCT00001251|Drug|Mafosfamide|
5825579|NCT00001250|Drug|preoperative dose intense chemotherapy (FLAC/G-CSF)|
5825580|NCT00001248|Device|MRI|MRI evaluations of brain, spinal cord, or optic nerves may be performed at field strengths of 1.5T, 3T, and/or 7T, under conditions designated by the FDA as constituting nonsignificant risk. Unless specifically designated below, MRI scans are performed on FDA- approved scanners with approved radiofrequency coils, and their use conforms to the corresponding FDA labels.
5825581|NCT00001248|Device|Coils|MRI evaluations of brain, spinal cord, or optic nerves may be performed at field strengths of 1.5T, 3T, and/or 7T, under conditions designated by the FDA as constituting nonsignificant risk. Unless specifically designated below, MRI scans are performed on FDA- approved scanners with approved radiofrequency coils, and their use conforms to the corresponding FDA labels.
5825582|NCT00001234|Genetic|human glucocerebrosidase cDNA|
5825583|NCT00001228|Drug|Interferon|
5825584|NCT00001221|Drug|Growth Hormone (Humatrope)|
5825585|NCT00001213|Drug|Cysteamine|
5825586|NCT00001212|Drug|prednisone|
5825587|NCT00001212|Drug|cyclophosphamide|
5825588|NCT00001212|Drug|cyclosporin A|
5825589|NCT00001202|Drug|Spironolactone|
5825590|NCT00001202|Drug|Testolactone|
5825591|NCT00001202|Drug|Deslorelin|
5825592|NCT00001197|Drug|Hydroxyurea|
5825593|NCT00001191|Drug|Pantoprazole|
5825594|NCT00001191|Drug|Omeprazole|
5825595|NCT00001182|Procedure|current standard of care treatments|
5825596|NCT00001181|Drug|Testolactone|
5825597|NCT00001180|Drug|Ovine Corticotropin-Releasing Hormone (oCRH)|
5825598|NCT00001165|Drug|combined chemotherapy with streptozotocin, 5-fluorouracil, and doxorubicin|
5825599|NCT00001155|Drug|cyclophosphamide|
5825600|NCT00001151|Drug|1,25-Dihydroxycholecalciferol|Usual doses of 1,25-dihydroycholecalciferol are 0.25-1 ug per day. All patients in this study received very high doses or 5-20 ug per day.
5825601|NCT00001146|Drug|Ethyl Eicosapentaenoic Acid|
5825602|NCT00001146|Drug|OmegaBrite|
5825603|NCT00001145|Drug|Bacteriophage|
5825604|NCT00001145|Drug|rhuCD40L|
5825605|NCT00001145|Drug|KLH|
5825606|NCT00001144|Drug|Modified bone marrow stem cell transplantation|
5825607|NCT00000426|Drug|Calcium supplement|
5825608|NCT00000425|Drug|Nonsteroidal anti-inflammatory drugs (NSAIDs)|
5825609|NCT00000425|Drug|Acetaminophen|
5825610|NCT00000424|Procedure|Tidal lavage vs. sham lavage of the knee|
5825611|NCT00000423|Behavioral|Social support group|
5825612|NCT00000423|Behavioral|Social support and education group|
5825613|NCT00000422|Behavioral|Cognitive-behavioral psychotherapy and physical exercise|
5825614|NCT00000421|Drug|Prednisone|
5825615|NCT00000421|Drug|Placebo|
5825616|NCT00000420|Drug|Ortho-Novum 777|
5825617|NCT00000419|Drug|Premarin and Provera|
5825618|NCT00000418|Procedure|Psychosocial intervention|
5825619|NCT00000417|Procedure|Counseling intervention|
5825620|NCT00000417|Device|Informational film|
5825621|NCT00000416|Other|Rehabilitation counseling|Provided in 2 in-person meetings and in follow-up phone calls
5825622|NCT00000415|Procedure|Physical activity|
5825623|NCT00000415|Drug|Calcium supplement|
5825624|NCT00000414|Behavioral|Arthritis Self-Management Program|
5825625|NCT00000414|Behavioral|SMART Program|
5825626|NCT00000413|Behavioral|Psychoeducational program|
5825627|NCT00000412|Drug|Alendronate|
5825628|NCT00000412|Drug|Calcitriol|
5825629|NCT00000412|Drug|Placebo Alendronate|
5825630|NCT00000412|Drug|Placebo Calcitriol|
5825631|NCT00000411|Procedure|Decompressive laminectomy|Removal of the hypertrophic inferior and superior articular facets will be performed when they are intruding upon the midline and causing both central and lateral recess stenosis.
5825632|NCT00000411|Other|Non-surgical treatments|Active physical therapy modality, Education/Counseling with home exercise instruction, and an NSAID if tolerated
5825633|NCT00000410|Procedure|Diskectomy|The surgeon will leave the nerve root freely mobile and undamaged following the procedure. During the procedure, the surgeon may consider using loop magnification or a microscope. The surgical incision will be midline and, after reflecting the paraspinous muscles, the interlaminar level will be identified and entered. The nerve root will be clearly identified and mobilized and then gently retracted to prepare for the discectomy. Removal of the medial border of the superior facet may, in some cases, be necessary in order to have a clear view of the lateral border of the involved nerve root. Following the clear view of the nerve root and mobilization, the IDH will be approached by making a small annular incision if necessary, the fragment of disc will then be removed (i.e., limited disc excision). A search of the canal will follow removal of the fragment, along with probing of the intervertebral-foramen for residual disc or bony pathology.
5825634|NCT00000410|Procedure|Non-surgical treatments|Active physical therapy modality, Education/Counseling with home exercise instruction, and an NSAID if tolerated
5825635|NCT00000409|Procedure|Decompressive laminectomy|Removal of the hypertrophic inferior and superior articular facets will be performed when they are intruding upon the midline and causing both central and lateral recess stenosis
5825636|NCT00000409|Other|Non-surgical treatments|Active physical therapy modality, Education/Counseling with home exercise instruction, and an NSAID if tolerated. Any non-operative therapies other than these are accepted and collected as data.
5825637|NCT00000409|Procedure|Fusion--Instrumented|In addition to decompressive laminectomy, additional bilateral non-instrumented or instrumented, i.e., posterior pedicle fixation, posterolateral fusion with autogenous bone grafting (utilizing iliac crest harvested from between the tables and/or local bone) will be performed between the transverse processes and the lateral portion of the superior facets of the involved levels.
5825638|NCT00000409|Procedure|Fusion-Non-instrumented|additional bilateral non-instrumented or instrumented, i.e., posterior pedicle fixation, posterolateral fusion with autogenous bone grafting (utilizing iliac crest harvested from between the tables and/or local bone) will be performed between the transverse processes and the lateral portion of the superior facets of the involved levels.
5825639|NCT00000408|Procedure|Patient education evaluation|
5825640|NCT00000407|Behavioral|Vocational counseling intervention|
5825641|NCT00000407|Behavioral|Reading materials for control participants|
5825642|NCT00000407|Behavioral|Standard of care|No education or behavioral intervention
5825643|NCT00000406|Procedure|Progressive resistance exercise|
5825644|NCT00000405|Procedure|Exercise intervention|
5825645|NCT00000404|Behavioral|Patient education in self-care of knee OA|
5825646|NCT00000403|Drug|Doxycycline|
5825647|NCT00000402|Drug|Calcium|
5825648|NCT00000401|Drug|Oral bovine type II collagen|Drug can be interrupted or stopped for suspected adverse events.
5825649|NCT00000400|Drug|Human parathyroid hormone [hPTH-(1-34)]|37 mcg once daily by self-administered sc injection
5825650|NCT00000400|Drug|alendronate|70 mg/week by oral route
5825651|NCT00000399|Drug|Hormone replacement therapy|
5825652|NCT00000399|Procedure|Strength training|
5825653|NCT00000398|Behavioral|Coping skills training|
5825654|NCT00000398|Behavioral|Physical exercise training|
5825655|NCT00000398|Behavioral|Coping skills training plus physical exercise training|
5825656|NCT00000397|Behavioral|Behavioral insomnia therapy|
5825657|NCT00000396|Behavioral|Patient self-care education|
5825658|NCT00000395|Drug|Methotrexate|
5825659|NCT00000395|Dietary Supplement|Folinic acid|
5825660|NCT00000395|Dietary Supplement|Folic acid|
5825661|NCT00000394|Procedure|Acupuncture therapy|
5825662|NCT00000105|Biological|Intracel KLH Vaccine|Intracel KLH 1000 mcg (1 mg) without adjuvant, subcutaneous Tetanus Toxoid 0.5 ml intramuscularly.
5825663|NCT00000105|Biological|Biosyn KLH|Biosyn KLH 1000 mcg (1 mg) without adjuvant, subcutaneous tetanus toxoid 0.5 ml intramuscularly.
5825664|NCT00000105|Drug|Montanide ISA51|Emulsify the KLH with Montanide ISA-51. The KLH 1 mg vial will be reconstituted in 0.5 mL sterile water. Once solubilized, add 0.6 mL of Montanide ISA to the vial and administered contents subcutaneously.
5825665|NCT00000105|Biological|Tetanus toxoid|Tetanus Toxoid Adsorbed, Aluminum Phosphate Adsorbed, PUROGENATED® (TT), is a sterile preparation of refined tetanus toxoid for intramuscular use only.
5825666|NCT00000104|Procedure|ERP measures of attention and memory|
5825667|NCT00000102|Drug|Nifedipine|
5825668|NCT00000458|Drug|sertraline (Zoloft)|
5825669|NCT00000458|Behavioral|cognitive behavior therapy|
5825670|NCT00000457|Drug|bupropion (Wellbutrin)|"1 pill in the am of 150 mg of Bupropion~1 pill (150 mg) in the AM and one in the PM for a total of 300 mg per day for subsequent 44 weeks."
5825671|NCT00000457|Drug|Placebo|placebo pill to match (look alike) the 150 mg pill of the bupropion given in the am for 3 days and then two pills (one in the morning and one at night) for the subsequent 44 mg.
5825672|NCT00000456|Drug|naltrexone (Revia)|
5825673|NCT00000456|Behavioral|cognitive behavior therapy|
5825674|NCT00000456|Behavioral|motivational enhancement therapy|
5825675|NCT00000455|Drug|naltrexone|
5825676|NCT00000454|Drug|nicotine replacement patch|
5825677|NCT00000452|Drug|naltrexone (Revia)|
5825678|NCT00000452|Behavioral|Compliance Enhancement Tech.|
5825679|NCT00000452|Behavioral|Cognitive Behavior Therapy|
5825680|NCT00000451|Drug|sertraline|16 week outpatient study
5825681|NCT00000451|Drug|naltrexone|16 week outpatient study
5825682|NCT00000450|Drug|Naltrexone Tablet|
5825683|NCT00000450|Drug|Matched Placebo Tablet|
5825685|NCT00000449|Behavioral|cognitive behavioral therapy|
5825686|NCT00000449|Behavioral|cue exposure treatment|
5825687|NCT00000448|Drug|naltrexone|Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
5825688|NCT00000448|Drug|Placebo|A placebo is a simulated or otherwise medically ineffectual treatment for a disease or other medical condition intended to deceive the recipient.
5825689|NCT00000447|Drug|naltrexone (Revia)|
5825690|NCT00000447|Drug|nicotine replacement patch|
5825691|NCT00000446|Drug|sertraline (Zoloft)|
5825692|NCT00000445|Drug|naltrexone (Revia)|
5825693|NCT00000444|Drug|nicotine replacement patch|
5825694|NCT00000443|Drug|ondansetron (Zofran)|
5825695|NCT00000442|Drug|naltrexone (Revia)|
5825696|NCT00000441|Drug|lorazepam (Ativan)|
5825697|NCT00000441|Drug|carbamazepine (Tegretol)|
5825698|NCT00000440|Drug|naltrexone (Revia)|
5825699|NCT00000440|Drug|sertraline (Zoloft)|
5825700|NCT00000439|Drug|sodium valproate|subjects were randomized to sodium valproate vs placebo. Serum sodium valproate was monitored. This intervention was added on treatment as usual which was defined as being on lithium carbonate and also attending individual dual recovery counseling.
5825701|NCT00000438|Drug|naltrexone (Revia)|
5825702|NCT00000437|Drug|Naltrexone Tablet and Nicotine Patch|
5825703|NCT00000437|Drug|Naltrexone Tablet and Placebo Patch|
5825704|NCT00000437|Drug|Placebo Tablet and Nicotine Patch|
5825705|NCT00000437|Drug|Placebo Tablet and Placebo Patch|
5825706|NCT00000389|Drug|Fluvoxamine|
5825707|NCT00000388|Behavioral|Psychosocial treatment|
5825708|NCT00000388|Drug|Anti-ADHD medication|
5825709|NCT00000388|Behavioral|Assessment-and-Referral|
5825710|NCT00000387|Behavioral|Self-management therapy|Behavioral
5825711|NCT00000387|Behavioral|Self-management therapy|
5825712|NCT00000386|Behavioral|Exposure and Response Prevention|
5825713|NCT00000386|Behavioral|Family Treatment Program|
5825714|NCT00000386|Behavioral|Relaxation Training|
5825715|NCT00000386|Behavioral|Behavior therapy|
5825716|NCT00000386|Behavioral|Family Counseling|
5825717|NCT00000385|Drug|Lithium|Lithium 600 mg to 2700 mg per day
5825718|NCT00000385|Drug|Placebo|Matching placebo
5825719|NCT00000384|Behavioral|Cognitive Behavior Therapy|
5825720|NCT00000384|Behavioral|Educational Support|
5825721|NCT00000384|Drug|Sertraline|
5825722|NCT00000383|Behavioral|Trauma-Focused CBT|Structured skills, exposure, trauma-specific interventions
5825723|NCT00000383|Behavioral|Child-Centered Therapy|Client-directed supportive interventions
5825724|NCT00000382|Behavioral|Infant-Parent Psychotherapy|
5825725|NCT00000382|Behavioral|Child Protective Services|
5825726|NCT00000382|Behavioral|Psychoeducational Home Visitation|
5825727|NCT00000382|Behavioral|Parent Education|
5825728|NCT00000381|Drug|Fluoxetine|
5825729|NCT00000380|Drug|GHRH|
5825730|NCT00000379|Drug|Fluoxetine|
5825731|NCT00000379|Behavioral|EMDR|
5825732|NCT00000378|Drug|Sertraline|12 week trial dose up to 200mgs
5825733|NCT00000378|Drug|Nortriptyline|12 week trial dose adjusted to therapeutic level
5825734|NCT00000377|Drug|Nortriptyline|
5825735|NCT00000376|Behavioral|Cognitive therapy|
5825736|NCT00000376|Drug|Desipramine|
5825737|NCT00000375|Drug|Nortriptyline-lithium (NOR-Li)|
5825738|NCT00000375|Procedure|Bilateral electroconvulsive therapy (ECT)|
5825739|NCT00000375|Drug|Continuation therapy|
5825740|NCT00000375|Behavioral|Continuation ECT|
5825741|NCT00000374|Drug|Olanzapine|The dosage for Olanzapine will be 2.5 mg to 20mg per day. The dose of the Olanzapine will be based on the participant's clinical improvement and side effects.
5825742|NCT00000374|Drug|Risperidone|The dosage for Risperidone will be 1 mg to 6mg per day. The dose of the Risperidone will be based on the participant's clinical improvement and side effects.
5825743|NCT00000373|Drug|olanzapine + fluoxetine|
5825744|NCT00000373|Drug|placebo + fluoxetine|
5825745|NCT00000372|Drug|D-cycloserine|
5825746|NCT00000372|Drug|Glycine|
5825747|NCT00000372|Drug|Clozapine|
5825748|NCT00000372|Drug|Placebo|
5825749|NCT00000371|Drug|D-cycloserine|50 mg/daily by mouth
5825750|NCT00000371|Drug|Placebo|50 mg/day of placebo by mouth
5825751|NCT00000370|Behavioral|Cognitive behavior therapy|
5825752|NCT00000370|Behavioral|Performance-based exposure therapy|
5825753|NCT00000370|Behavioral|Psychosocial intervention|
5825754|NCT00000369|Behavioral|Individual psychotherapy|
5825755|NCT00000369|Drug|Lithium carbonate|
5825756|NCT00000368|Behavioral|Cognitive behavior therapy|
5825757|NCT00000368|Drug|Paroxetine or other medication - algorithm used|
5825758|NCT00000367|Drug|Treatment of depression|
5825759|NCT00000367|Behavioral|Suicide prevention intervention|
5825760|NCT00000367|Drug|Suicide prevention treatment|
5825761|NCT00000363|Drug|Antihistamine|
5825762|NCT00000363|Drug|Corticosteroid|
5825763|NCT00000362|Behavioral|Chin-down position|
5825764|NCT00000362|Behavioral|Thickened liquid administration|
5825765|NCT00000361|Drug|Corticosteroids|
5825766|NCT00000361|Drug|Methotrexate|
5825767|NCT00000359|Behavioral|Canalith repositioning maneuver (Epley maneuver)|Standard passive motion of the head: Dix-Hallpike maneuver, turn head to opposite side, roll over, sit up.
5825768|NCT00000359|Behavioral|Semont maneuver|Sidelying maneuver, flip over 180 deg, sit up.
5825769|NCT00000359|Behavioral|Brandt-Daroff exercises|Active exercise. Sidelying to involved side, sidelying to uninvolved side, sit up.
5825770|NCT00000359|Behavioral|Vestibular habituation exercises|Head shaking exercises in pitch, roll, yaw and circumduction. Titrating from 2 repetitions per exercise to 20 repetitions per exercise, as tolerated.
5825771|NCT00000359|Behavioral|ShamManeuver|Passive movement of the head
5825778|NCT00000176|Drug|Estrogen and Progesterone|
5825779|NCT00000175|Drug|Estrogen|
5825780|NCT00000175|Drug|Testosterone|
5825781|NCT00000174|Drug|Rivastigmine|
5825782|NCT00000173|Drug|Donepezil|
5825783|NCT00000173|Drug|Vitamin E|
5825784|NCT00000172|Drug|Galantamine|
5825785|NCT00000171|Drug|Melatonin|
5825786|NCT00000623|Drug|Deferoxamine|
5825787|NCT00000623|Drug|Deferiprone|
5825788|NCT00000623|Drug|Arginine|
5825789|NCT00000623|Drug|Sildenafil|
5825790|NCT00000623|Drug|Decitabine|
5825791|NCT00000621|Drug|all trans retinoic acid|
5825792|NCT00000621|Drug|13 cis retinoic acid|
5825793|NCT00000621|Drug|placebo|
5825794|NCT00000620|Drug|Anti-hyperglycemic Agents|Multiple drugs including insulins and oral anti-hyperglycemic agents as needed to reach Glycemia Trial arm-specific goals (intensive control <6%; standard control 7.0-7.9%).
5825795|NCT00000620|Drug|Anti-hypertensive Agents|Multiple anti-hypertensive agents as needed to reach Blood Pressure Trial arm-specific goals (intensive control <120 mm Hg; standard control <140 mm Hg).
5825796|NCT00000620|Drug|Blinded fenofibrate or placebo plus simvastatin|Double blind administration of 160 mg/day of fenofibrate in participants with estimated glomerular filtration rate (eGFR) ≥50 mL/min/1.73m2 or 54 mg/day in patients with eGFR <50 mL/min/1.73m2 or matching placebo in combination with open label simvastatin 20 - 40 mg/day.
5825797|NCT00000619|Procedure|catheterization, Swan-Ganz|
5825798|NCT00000617|Drug|azithromycin|
5825799|NCT00000616|Behavioral|diet, sodium-restricted|
5825800|NCT00000616|Behavioral|diet, fat-restricted|
5825801|NCT00000616|Behavioral|exercise|
5825802|NCT00000616|Behavioral|diet, reducing|
5825803|NCT00000616|Behavioral|alcohol drinking|
5825804|NCT00000615|Behavioral|diet, reducing|
5825805|NCT00000614|Drug|warfarin|
5825806|NCT00000613|Behavioral|dietary supplements|
5825807|NCT00000613|Drug|genistein|
5825808|NCT00000613|Behavioral|diet, soy proteins|
5825809|NCT00000612|Drug|estrogens, conjugated|
5825810|NCT00000612|Behavioral|diet, soy proteins|
5825811|NCT00000612|Behavioral|dietary supplements|
5825812|NCT00000611|Drug|hormone replacement therapy|
5825813|NCT00000611|Drug|estrogens|
5825814|NCT00000611|Drug|progestins|
5825815|NCT00000611|Drug|estrogen replacement therapy|
5825816|NCT00000611|Behavioral|diet, fat-restricted|
5825817|NCT00000611|Drug|calcium|
5825818|NCT00000611|Drug|vitamin D|
5825819|NCT00000611|Behavioral|dietary supplements|
5825820|NCT00000610|Drug|magnesium|
5825821|NCT00000609|Drug|amiodarone|
5825822|NCT00000609|Device|defibrillators, implantable|
5825823|NCT00000608|Behavioral|diet, fat-restricted|
5825824|NCT00000608|Behavioral|diet, sodium-restricted|
5825825|NCT00000607|Device|Left ventricular assist device|A type of implantable heart pump
5825826|NCT00000607|Device|Optimal medical therapy|(non-experimental) One possibility in handling Heart failure effectively is optimal medicine therapy. The most popular treatment medications at present are ACE Inhibitors and Beta Blockers. The result is the heart being able to pump more effectively and allowing blood to circulate freely.
5825827|NCT00000606|Procedure|Lung volume reduction surgery|
5825828|NCT00000605|Drug|hormone replacement therapy|
5825829|NCT00000605|Drug|estrogens|
5825830|NCT00000605|Drug|medroxyprogesterone|
5825831|NCT00000604|Procedure|cardiopulmonary bypass|
5825832|NCT00000604|Procedure|heart arrest, induced|
5825833|NCT00000603|Procedure|stem cell transplantation|
5825834|NCT00000602|Drug|hydroxyurea|
5825835|NCT00000601|Drug|estrogen replacement therapy|
5825836|NCT00000601|Drug|estrogens|
5825837|NCT00000601|Drug|progesterone|
5825838|NCT00000601|Drug|hormone replacement therapy|
5825839|NCT00000600|Drug|Vitamin E|
5825840|NCT00000600|Drug|Vitamin C|
5825841|NCT00000599|Drug|colestipol|
5825842|NCT00000599|Drug|niacin|
5825843|NCT00000599|Behavioral|diet, fat-restricted|
5825844|NCT00000598|Behavioral|diet, fat-restricted|
5825845|NCT00000598|Behavioral|exercise|
5825846|NCT00000597|Drug|antilymphocyte serum|
5825847|NCT00000597|Drug|nandrolone|
5825848|NCT00000596|Drug|prednisone|
5825849|NCT00000596|Drug|cyclophosphamide|
5825850|NCT00000596|Drug|dapsone|
5825851|NCT00000595|Drug|deferoxamine|
5825852|NCT00000594|Drug|cholestyramine|
5825853|NCT00000593|Procedure|blood transfusion|
5825854|NCT00000592|Procedure|blood transfusion|
5825855|NCT00000591|Procedure|lymphocyte depletion|
5825856|NCT00000590|Drug|immunoglobulins|
5825857|NCT00000589|Procedure|platelet transfusion|
5825858|NCT00000588|Drug|chelation therapy|
5825859|NCT00000587|Procedure|erythropoietin, recombinant|
5825860|NCT00000586|Drug|hydroxyurea|
5825861|NCT00000585|Drug|penicillin|
5825862|NCT00000584|Drug|immunoglobulins|
5825863|NCT00000583|Biological|hepatitis B vaccines|
5825864|NCT00000582|Drug|factor ix|
5825865|NCT00000581|Procedure|leukocyte transfusions|
5825866|NCT00000580|Drug|immunoglobulins, intravenous|
5825867|NCT00000579|Procedure|Low Tidal Volume Ventilation|
5825868|NCT00000579|Procedure|Positive End-Expiratory Pressure|
5825869|NCT00000579|Drug|Lysofylline|
5825870|NCT00000579|Drug|Methylprednisolone|
5825871|NCT00000579|Drug|Ketoconazole|
5825872|NCT00000579|Procedure|Fluid Management|
5825873|NCT00000579|Procedure|Pulmonary Artery Catheter|
5825874|NCT00000578|Drug|theophylline|
5825875|NCT00000578|Drug|beclomethasone|
5825876|NCT00000577|Drug|Albuterol|
5825877|NCT00000577|Drug|Colchicine|
5826083|NCT00000496|Drug|dipyridamole|
5825878|NCT00000577|Drug|Adrenal Cortex Hormones|
5825879|NCT00000577|Drug|Adrenergic-Beta Agonists|
5825880|NCT00000576|Drug|beclomethasone|
5825881|NCT00000575|Drug|Placebo|Two 100 Og puffs budesonide placebo bid + two 90 Og puffs albuterol prn OR four 2 mg puffs nedocromil placebo bid + two 90 Og puffs albuterol prn.
5825882|NCT00000575|Drug|Nedocromil|Four 2 mg puffs bid + two 90 Og puffs albuterol prn
5825883|NCT00000575|Drug|Budesonide|Two 100 Og puffs bid + two 90 Og puffs albuterol prn.
5825884|NCT00000574|Drug|ibuprofen|
5825885|NCT00000573|Procedure|enteral nutrition|
5825886|NCT00000572|Procedure|positive-pressure ventilation|Detailed computer protocol controlled positive pressure ventilation
5825887|NCT00000572|Procedure|extracorporeal membrane oxygenation (CO2 removal)|Detailed computer protocol controlled Extracorporeal CO2 Removal with reduced positive pressure ventilation
5825888|NCT00000571|Device|ventilators, negative pressure|
5825889|NCT00000570|Drug|pulmonary surfactant|
5825890|NCT00000569|Drug|triamcinolone|1200 micrograms of triamcinolone in daily divided doses
5825891|NCT00000569|Other|Placebo|Placebo
5825892|NCT00000568|Behavioral|smoking cessation|
5825893|NCT00000568|Drug|ipratropium|
5825894|NCT00000567|Procedure|high-frequency ventilation|
5825895|NCT00000566|Procedure|ventilation-perfusion ratio|
5825896|NCT00000566|Procedure|angiography|
5825897|NCT00000565|Procedure|intermittent positive-pressure breathing|
5825898|NCT00000564|Procedure|oxygen inhalation therapy|
5825899|NCT00000563|Drug|dexamethasone|
5825900|NCT00000562|Procedure|extracorporeal membrane oxygenation|
5825901|NCT00000561|Device|pacemaker, artificial|
5825902|NCT00000560|Drug|adrenergic beta antagonists|
5825903|NCT00000559|Drug|estrogen replacement therapy|
5825904|NCT00000559|Drug|hormone replacement therapy|
5825905|NCT00000559|Drug|estradiol|
5825906|NCT00000559|Drug|medroxyprogesterone|
5825907|NCT00000558|Drug|angiotensin-converting enzyme inhibitors|
5825908|NCT00000557|Behavioral|social support|
5825909|NCT00000556|Drug|amiodarone|
5825910|NCT00000556|Drug|sotalol|
5825911|NCT00000556|Drug|propafenone|
5825912|NCT00000556|Drug|flecainide|
5825913|NCT00000556|Drug|quinidine|
5825914|NCT00000556|Drug|moricizine|
5825915|NCT00000556|Drug|disopyramide|
5825916|NCT00000556|Drug|procainamide|
5825917|NCT00000556|Drug|adrenergic beta antagonists|
5825918|NCT00000556|Drug|verapamil|
5825919|NCT00000556|Drug|diltiazem|
5825920|NCT00000556|Drug|digoxin|
5825921|NCT00000556|Procedure|catheter ablation|
5825922|NCT00000556|Device|pacemaker, artificial|
5825923|NCT00000555|Drug|estrogen replacement therapy|
5825924|NCT00000555|Drug|estrogens, conjugated|
5825925|NCT00000555|Drug|progesterone|
5825926|NCT00000555|Drug|hormone replacement therapy|
5825927|NCT00000555|Drug|supplementation, food|
5825928|NCT00000555|Drug|ascorbic acid|
5825929|NCT00000555|Drug|vitamin e|
5825930|NCT00000554|Procedure|Angiography, MRI, Dobutamine-Stress Echocardiography, PET,|
5825931|NCT00000554|Procedure|Myocardial Contrast Echo, Coronary Flow and Vasomotor Testing|
5825932|NCT00000553|Drug|simvastatin|
5825933|NCT00000553|Drug|niacin|
5825934|NCT00000553|Drug|antioxidants|
5825935|NCT00000552|Procedure|angioplasty, transluminal, percutaneous coronary|
5825936|NCT00000552|Procedure|coronary artery bypass|
5825937|NCT00000552|Drug|thrombolytic therapy|
5825938|NCT00000551|Behavioral|health education|
5825939|NCT00000550|Behavioral|health education|
5825940|NCT00000549|Drug|estrogen replacement therapy|
5825941|NCT00000549|Drug|hormone replacement therapy|
5825942|NCT00000549|Drug|estrogens|
5825943|NCT00000549|Drug|progestins|
5825944|NCT00000548|Procedure|mechanical ventilation|
5825945|NCT00000547|Drug|enalapril|
5825946|NCT00000546|Behavioral|meditation|
5825947|NCT00000545|Behavioral|exercise|
5825948|NCT00000545|Behavioral|diet|
5825949|NCT00000544|Behavioral|diet therapy|
5825950|NCT00000543|Behavioral|dietary supplements|
5825951|NCT00000543|Drug|calcium|
5825952|NCT00000542|Drug|Inhibitors, ACE|
5825953|NCT00000542|Drug|amlodipine|
5825954|NCT00000542|Drug|lisinopril|
5825955|NCT00000542|Drug|doxazosin|
5825956|NCT00000542|Drug|chlorthalidone|
5825957|NCT00000542|Drug|pravastatin|
5825958|NCT00000542|Behavioral|diet, fat-restricted|
5825959|NCT00000541|Behavioral|dietary supplements|
5825960|NCT00000541|Drug|vitamin C|
5825961|NCT00000541|Drug|vitamin E|
5825962|NCT00000541|Drug|beta-carotene|
5825963|NCT00000541|Drug|folic acid/Vitamin B6/Vitamin B12|
5825964|NCT00000540|Device|defibrillators, implantable|
5825965|NCT00000539|Drug|niacin|
5825966|NCT00000539|Drug|pravastatin|
5825967|NCT00000539|Drug|beta-carotene|
5825968|NCT00000539|Drug|vitamin E|
5825969|NCT00000539|Behavioral|dietary supplements|
5825970|NCT00000539|Drug|vitamin C|
5825971|NCT00000539|Drug|warfarin|
5825972|NCT00000538|Behavioral|diet, fat-restricted|
5825973|NCT00000537|Behavioral|meditation|
5825974|NCT00000537|Behavioral|relaxation|
5825975|NCT00000536|Behavioral|sodium, dietary|
5825976|NCT00000535|Behavioral|diet, reducing|
5825977|NCT00000535|Behavioral|diet, sodium-restricted|
5825978|NCT00000534|Drug|calcium|
5825979|NCT00000534|Behavioral|dietary supplements|
5825980|NCT00000533|Behavioral|social support|
5825981|NCT00000532|Behavioral|diet, fat-restricted|
5825982|NCT00000531|Device|defibrillators, implantable|
5825983|NCT00000531|Drug|amiodarone amiodarone|
5825984|NCT00000531|Drug|sotalol|
5825985|NCT00000530|Drug|nifedipine|
5825986|NCT00000530|Behavioral|biofeedback (psychology)|
5825987|NCT00000530|Procedure|electromyography|
5825988|NCT00000529|Drug|tamoxifen|
5825989|NCT00000528|Behavioral|diet, sodium-restricted (Phase III) diet, sodium-restricted|
5825990|NCT00000528|Behavioral|diet, reducing (Phase III)|
5825991|NCT00000527|Drug|aspirin|
5825992|NCT00000527|Drug|dipyridamole|
5825993|NCT00000526|Drug|encainide|
5825994|NCT00000526|Drug|flecainide|
5825995|NCT00000526|Drug|moricizine|
5825996|NCT00000525|Drug|hydrochlorothiazide|
5825997|NCT00000525|Behavioral|diet, potassium supplementation|
5825998|NCT00000525|Behavioral|diet, magnesium supplementation|
5825999|NCT00000525|Drug|triamterene|
5826000|NCT00000525|Drug|chlorthalidone|
5826001|NCT00000524|Drug|cyclosporine|
5826002|NCT00000524|Drug|prednisone|
5826003|NCT00000523|Behavioral|exercise|
5826004|NCT00000522|Behavioral|diet, sodium-restricted|
5826005|NCT00000522|Behavioral|diet, reducing|
5826006|NCT00000522|Behavioral|exercise|
5826007|NCT00000522|Behavioral|alcohol restriction|
5826008|NCT00000522|Drug|chlorthalidone|
5826009|NCT00000522|Drug|acebutolol|
5826010|NCT00000522|Drug|doxazosin|
5826011|NCT00000522|Drug|amlodipine|
5826012|NCT00000522|Drug|enalapril|
5826013|NCT00000521|Behavioral|diet, sodium-restricted|
5826014|NCT00000521|Behavioral|diet, potassium-supplemented|
5826015|NCT00000520|Drug|immunoglobulins, intravenous|
5826016|NCT00000520|Drug|aspirin|
5826017|NCT00000519|Behavioral|diet, reducing|
5826018|NCT00000519|Behavioral|exercise|
5826019|NCT00000519|Behavioral|diet, fat-restricted|
5826020|NCT00000518|Procedure|electrophysiology|
5826021|NCT00000518|Procedure|electrocardiography, ambulatory|
5826022|NCT00000518|Drug|imipramine|
5826023|NCT00000518|Drug|mexiletine|
5826024|NCT00000518|Drug|procainamide|
5826025|NCT00000518|Drug|quinidine|
5826026|NCT00000518|Drug|sotalol|
5826027|NCT00000517|Drug|warfarin|
5826028|NCT00000516|Drug|enalapril|
5826029|NCT00000515|Behavioral|diet, reducing|
5826030|NCT00000514|Drug|chlorthalidone|
5826031|NCT00000514|Drug|atenolol|
5826032|NCT00000514|Drug|reserpine|
5826033|NCT00000513|Behavioral|diet, reducing|
5826034|NCT00000513|Behavioral|diet, sodium-restricted|
5826035|NCT00000513|Drug|chlorthalidone|
5826036|NCT00000513|Drug|atenolol|
5826037|NCT00000512|Drug|lovastatin|Lovastatin was begun at a dose of 20 mg twice a day (in the morning and at bedtime). If the LDL cholesterol level did not fall below 3.1 mmol per liter after three months, the dose of lovastatin was increased to 40 mg twice a day.
5826038|NCT00000512|Drug|colestipol|Colestipol was begun at a dose of 5 g three times a day with meals and increased to 10 g three times a day after 10 days, unless side effects delayed the increase. Psyllium hydrophic mucilloid (Metamucil) was provided if dietary bran was insufficient to control constipation.
5826039|NCT00000512|Drug|niacin|Niacin was started at 125 mg twice a day and gradually increased to 500 mg four times a day (with meals and at bedtime) at one month and 1 g four times a day at two months. If the LDL cholesterol level did not fall below 3.1 mmol per liter (120 mg per deciliter) after three months, the dose of niacin was increased to 1.5 g (three tablets) four times a day, but no further.
5826040|NCT00000512|Other|Placebo for colestipol|Placebo for colestipol.
5826041|NCT00000512|Other|Placebo for lovastatin|Placebo for lovastatin
5826042|NCT00000511|Dietary Supplement|mineral supplements|
5826043|NCT00000511|Dietary Supplement|Trial 1: fatty acids, omega-3; Trial 2: Mineral supplements|
5826044|NCT00000511|Behavioral|dietary supplements|
5826045|NCT00000510|Drug|aspirin|
5826046|NCT00000510|Drug|dipyridamole|
5826047|NCT00000510|Procedure|angioplasty, transluminal, percutaneous coronary|
5826048|NCT00000509|Behavioral|diet, sodium-restricted|
5826049|NCT00000509|Behavioral|diet, potassium-supplementation|
5826050|NCT00000508|Behavioral|smoking cessation|
5826051|NCT00000508|Behavioral|diet, reducing|
5826052|NCT00000508|Behavioral|exercise|
5826053|NCT00000508|Behavioral|diet, fat-restricted|
5826054|NCT00000507|Drug|streptokinase|
5826055|NCT00000506|Drug|fenfluramine|
5826056|NCT00000506|Drug|phentermine|
5826057|NCT00000505|Drug|tissue plasminogen activator|
5826058|NCT00000505|Procedure|angioplasty, transluminal, percutaneous coronary|
5826059|NCT00000504|Drug|encainide|
5826060|NCT00000504|Drug|moricizine|
5826061|NCT00000504|Drug|flecainide|
5826062|NCT00000504|Drug|imipramine|
5826063|NCT00000503|Drug|nitroglycerin|
5826064|NCT00000503|Drug|streptokinase|
5826065|NCT00000503|Procedure|heart catheterization|
5826066|NCT00000502|Procedure|cardiopulmonary resuscitation|
5826067|NCT00000501|Behavioral|diet, sodium-restricted|
5826068|NCT00000501|Behavioral|diet, reducing|
5826069|NCT00000501|Drug|potassium|
5826070|NCT00000500|Drug|aspirin|
5826071|NCT00000500|Drug|carotene|
5826072|NCT00000499|Drug|chlorthalidone|
5826073|NCT00000499|Drug|reserpine|
5826074|NCT00000499|Drug|hydralazine|
5826075|NCT00000499|Drug|metoprolol|
5826076|NCT00000498|Behavioral|diet, sodium-restricted|
5826077|NCT00000498|Behavioral|diet, reducing|
5826078|NCT00000498|Behavioral|alcohol restriction|
5826079|NCT00000498|Drug|antihypertensive agents|
5826080|NCT00000497|Behavioral|diet, sodium-restricted|
5826081|NCT00000497|Behavioral|diet, reducing|
5826082|NCT00000496|Drug|aspirin|
5826084|NCT00000495|Behavioral|diet, reducing|
5826085|NCT00000495|Behavioral|diet, sodium-restricted|
5826086|NCT00000495|Behavioral|alcohol restriction|
5826087|NCT00000495|Behavioral|exercise|
5826088|NCT00000494|Drug|indomethacin|
5826089|NCT00000494|Procedure|surgery, cardiovascular|
5826090|NCT00000493|Drug|propranolol|
5826091|NCT00000493|Drug|hyaluronidase|
5826092|NCT00000492|Drug|propranolol|
5826093|NCT00000491|Drug|aspirin|
5826094|NCT00000490|Procedure|jejunoileal bypass|
5826095|NCT00000490|Behavioral|diet, fat-restricted|
5826096|NCT00000489|Procedure|coronary artery bypass|
5826097|NCT00000488|Drug|cholestyramine|
5826098|NCT00000488|Behavioral|diet, fat-restricted|
5826099|NCT00000487|Drug|antihypertensive agents|
5826100|NCT00000487|Behavioral|smoking cessation|
5826101|NCT00000487|Behavioral|diet, fat-restricted|
5826102|NCT00000487|Drug|diuretics|
5826103|NCT00000486|Procedure|coronary artery bypass|
5826104|NCT00000485|Drug|diuretics|
5826105|NCT00000485|Drug|antihypertensive agents|
5826106|NCT00000484|Drug|chlorothiazide|
5826107|NCT00000484|Drug|Rauwolfia alkaloids|
5826108|NCT00000483|Drug|estrogen|
5826109|NCT00000483|Drug|clofibrate|
5826110|NCT00000483|Drug|dextrothyroxine sodium|
5826111|NCT00000483|Drug|niacin|
5826112|NCT00000482|Drug|estrogen|
5826113|NCT00000482|Drug|clofibrate clofibrate|
5826114|NCT00000482|Drug|dextrothyroxine sodium|
5826115|NCT00000482|Drug|niacin|
5826116|NCT00000481|Behavioral|diet, fat-restricted|
5826117|NCT00000480|Procedure|electrophysiology|
5826118|NCT00000480|Drug|anti-arrhythmia agents|
5826119|NCT00000480|Device|defibrillators, implantable|
5826120|NCT00000479|Drug|Aspirin|Participants will receive 100 mg of aspirin every other day.
5826121|NCT00000479|Drug|Vitamin E|Participants will receive 600 IU of vitamin E every other day.
5826122|NCT00000479|Behavioral|Placebo|Participants will receive placebo.
5826123|NCT00000478|Drug|atenolol|
5826124|NCT00000478|Drug|nifedipine|
5826125|NCT00000478|Drug|diltiazem|
5826126|NCT00000478|Drug|isosorbide dinitrate|
5826127|NCT00000478|Procedure|coronary artery bypass coronary artery bypass|
5826128|NCT00000478|Procedure|angioplasty, transluminal, percutaneous coronary|
5826129|NCT00000477|Drug|lovastatin|
5826130|NCT00000476|Drug|digitalis|
5826131|NCT00000475|Behavioral|health education|
5826132|NCT00000474|Behavioral|behavior therapy|
5826133|NCT00000473|Behavioral|dietary supplements|
5826134|NCT00000473|Drug|fatty acids, omega-3|
5826135|NCT00000473|Behavioral|diet, fat-restricted|
5826136|NCT00000472|Drug|tissue plasminogen activator|
5826137|NCT00000472|Drug|heparin|
5826138|NCT00000471|Behavioral|diet, vegetarianism|
5826139|NCT00000471|Behavioral|diet, fat-restricted|
5826140|NCT00000471|Behavioral|exercise|
5826141|NCT00000471|Behavioral|smoking cessation|
5826142|NCT00000470|Procedure|cardiac surgical procedures|
5826143|NCT00000470|Procedure|cardiopulmonary bypass|
5826144|NCT00000469|Drug|aspirin|
5826145|NCT00000469|Drug|lovastatin|
5826146|NCT00000468|Drug|tissue plasminogen activator|
5826147|NCT00000467|Behavioral|diet|
5826148|NCT00000467|Behavioral|exercise|
5826149|NCT00000467|Behavioral|smoking cessation|
5826150|NCT00000466|Drug|estrogens, conjugated|
5826151|NCT00000466|Drug|medroxyprogesterone|
5826152|NCT00000466|Drug|progesterone|
5826153|NCT00000466|Drug|estrogen replacement therapy|
5826154|NCT00000465|Procedure|angioplasty, transluminal, percutaneous coronary|
5826155|NCT00000465|Procedure|coronary artery bypass|
5826156|NCT00000464|Drug|amiodarone|
5826157|NCT00000464|Drug|imipramine|
5826158|NCT00000464|Drug|mexiletine|
5826159|NCT00000464|Drug|procainamide|
5826160|NCT00000464|Drug|propafenone|
5826161|NCT00000464|Drug|quinidine|
5826162|NCT00000464|Drug|sotalol|
5826163|NCT00000463|Drug|lovastatin|
5826164|NCT00000463|Drug|cholestyramine|
5826165|NCT00000463|Drug|warfarin|
5826166|NCT00000462|Procedure|angioplasty, transluminal, percutaneous coronary|
5826167|NCT00000462|Procedure|coronary artery bypass|
5826168|NCT00000461|Drug|pravastatin|
5826169|NCT00000461|Drug|niacin|
5826170|NCT00000461|Drug|cholestyramine|
5826171|NCT00000461|Drug|gemfibrozil|
5826172|NCT00000461|Drug|fatty acids, omega-3|
5826173|NCT00000460|Behavioral|Low intensity exercise|
5826174|NCT00000460|Behavioral|High intensity exercise|
5826175|NCT00000459|Behavioral|diet, fat-restricted|
5826176|NCT00004500|Drug|Lucinactant|Lucinactant suspension was administered as 10 mg total phospholipid (TPL)/mL, by bronchoalveolar lavage within 90 minutes of randomization. The dose was determined based on the infant's body weight such that the total dose was 16 mL/kg for each of the 2 lavage procedures and 32 mL/kg overall. Infants received 2 doses of lucinactant. Each dose consisted of separate lavage procedures for each lung within 15 minutes (up to 60 minutes) of each other.
5826177|NCT00004500|Other|Standard Care|The Standard Care (SC) group received therapies including, but not limited to, the use of oxygen, controlled mechanical ventilation (CMV), sedation, paralysis, vasopressors, and/or alkalinization. The use of adjunctive therapies (namely: high frequency oscillatory ventilation, high frequency jet ventilation, bolus surfactant, inhaled nitric oxide, extra-corporeal membrane oxygenation, or systemic corticosteroids) were not included in SC
5826178|NCT00004498|Genetic|Adenoviral Vector-Mediated Gene Transfer|
5826179|NCT00004497|Drug|UT-15|
5826180|NCT00004496|Drug|alpha-melanocyte stimulating hormone|
5826181|NCT00004495|Drug|cyanocobalamin|
5826184|NCT00004494|Drug|vasoactive intestinal peptide|
5826185|NCT00004493|Drug|sodium dichloroacetate|
5826186|NCT00004492|Drug|clotrimazole|
5826187|NCT00004492|Drug|hydroxyurea|
5826188|NCT00004490|Drug|sodium dichloroacetate|
5826189|NCT00004489|Drug|alendronate sodium|
5826190|NCT00004489|Drug|calcium carbonate|
5826191|NCT00004489|Drug|cholecalciferol|
5826192|NCT00004488|Drug|alendronate sodium|
5826193|NCT00004488|Drug|calcium carbonate|
5826194|NCT00004488|Drug|cholecalciferol|
5826195|NCT00004487|Drug|chondrocyte-alginate gel suspension|
5826196|NCT00004486|Drug|fluoxetine|
5826197|NCT00004485|Drug|cyclosporine|
5826198|NCT00004485|Drug|fludarabine|
5826199|NCT00004485|Drug|mycophenolate mofetil|
5826200|NCT00004485|Procedure|Bone Marrow Transplantation|
5826201|NCT00004482|Drug|Cyclosporine|
5826202|NCT00004482|Drug|methylprednisolone|
5826203|NCT00004482|Drug|Muromonab-CD3|
5826204|NCT00004482|Drug|prednisone|
5826205|NCT00004481|Procedure|genetic testing|
5826206|NCT00004480|Drug|botulinum toxin type A|
5826207|NCT00004479|Drug|midodrine|
5826208|NCT00004478|Drug|droxidopa|
5826209|NCT00004474|Drug|Anti-thymocyte globulin|Given via IV over 4 hours
5826210|NCT00004474|Drug|Cyclophosphamide|Given via IV over 60 minutes on Days -5 to -2
5826211|NCT00004474|Procedure|Bone marrow transplantation|Given on Day 0
5826212|NCT00004471|Genetic|pGT-1 gene lipid complex|
5826213|NCT00004468|Drug|calcitriol|
5826214|NCT00004467|Drug|N-acetylcysteine (NAC)|Infusion of 5% dextrose with N-acetylcysteine with an initial loading dose of 150 mg/kg/h of NAC over 1 hour, followed by 12.5 mg/kg/h for 4 hours, then continuous infusions of 6.25 mg/kg/h for the remaining 67 hours.
5826215|NCT00004467|Drug|Placebo|Infusion of 5% dextrose
5826216|NCT00004466|Drug|Atorvastatin|
5826217|NCT00004466|Drug|Placebo|
5826218|NCT00004465|Drug|SYNSORB Pk|
5826219|NCT00004465|Drug|Placebo|
5826220|NCT00004464|Drug|cyclophosphamide|
5826221|NCT00004464|Drug|filgrastim|
5826222|NCT00004454|Genetic|lymphocyte gene therapy|
5826223|NCT00004451|Drug|Glucose|
5826224|NCT00004450|Drug|glyceryl trierucate|
5826225|NCT00004450|Drug|glyceryl trioleate|
5826226|NCT00004450|Drug|interferon beta|
5826227|NCT00004450|Drug|thalidomide|
5826228|NCT00004449|Behavioral|intensive one-on-one behavioral treatment|Up to 40 hours per week of one-to-one intervention based on applied behavior analysis
5826229|NCT00004449|Behavioral|Individualized in home parent training|Offered to subjects at some sites, involved 3+ months of individualized training for parents on applied behavior analysis intervention
5826230|NCT00004448|Drug|omega-3 fatty acids|
5826231|NCT00004448|Drug|prednisone|
5826232|NCT00004446|Drug|fluoxetine|
5826233|NCT00004445|Procedure|Surgery|
5826234|NCT00004445|Device|IRS-8|
5826235|NCT00004444|Drug|paromomycin|
5826236|NCT00004444|Drug|streptomycin|
5826237|NCT00004443|Drug|NTBC|
5826238|NCT00004442|Drug|chenodeoxycholic acid|
5826239|NCT00004442|Drug|cholic acid|
5826240|NCT00004442|Drug|ursodiol|
5826241|NCT00004441|Drug|tauroursodeoxycholic acid|
5826242|NCT00004441|Drug|ursodiol|
5826243|NCT00004440|Drug|ibuprofen|
5826244|NCT00004438|Drug|leuprolide|
5826245|NCT00004437|Device|Multichannel Auditory Brain Stem Implant|
5826246|NCT00004436|Drug|leuprolide|
5826247|NCT00004436|Drug|prednisone|
5826248|NCT00004433|Drug|pergolide|
5826249|NCT00004431|Drug|L-baclofen|
5826250|NCT00004430|Drug|Dihematoporphyrin derivative|
5826251|NCT00004430|Drug|prednisolone|
5826252|NCT00004430|Procedure|Laser surgery|
5826253|NCT00004429|Drug|growth hormone|
5826254|NCT00004428|Drug|CPX|
5826255|NCT00004426|Drug|gonadotropin releasing hormone|
5826256|NCT00004426|Drug|leuprolide|
5826257|NCT00004424|Drug|fentanyl|
5826258|NCT00004424|Drug|Midazolam|
5826259|NCT00004424|Drug|propofol|
5826260|NCT00004423|Drug|-aminosalicylic acid|
5826261|NCT00004422|Drug|immune globulin|
5826262|NCT00004421|Device|implanted pulse generator|
5826263|NCT00004420|Drug|gamma-Linolenic acid|
5826264|NCT00004419|Drug|insulin-like growth factor I|
5826265|NCT00004418|Drug|glyceryl trierucate|Glyceryl trierucate is an oil to reduce very long chain fatty acids
5826266|NCT00004418|Drug|glyceryl trioleate|Patients receive 2-4 tablespoons of a mixture of glyceryl trierucate and glyceryl trioleate oil once daily.
5826267|NCT00004416|Drug|botulinum toxin type A|
5826268|NCT00004415|Device|Medlink spinal cord electrode|
5826269|NCT00004414|Drug|sincalide|
5826270|NCT00004412|Drug|Arginine Butyrate|To determine if Arginine Butyrate accelerates healing of refractory leg ulcers over Standard Local Care alone.
5826271|NCT00004412|Other|Standard local care dressing|To heal leg ulcers.
5826272|NCT00004410|Drug|tauroursodeoxycholic acid|
5826273|NCT00004409|Drug|collagenase|
5826274|NCT00004408|Drug|poloxamer 188|
5826275|NCT00004407|Drug|immune globulin|
5826276|NCT00004406|Drug|human parathyroid hormone|
5826277|NCT00004404|Drug|clotrimazole|
5826278|NCT00004404|Drug|hydroxyurea|
5826279|NCT00004403|Drug|albendazole|
5826280|NCT00004403|Drug|dexamethasone|
5826281|NCT00004403|Drug|phenytoin|
5826282|NCT00004402|Drug|calcitriol|
5826283|NCT00004402|Drug|interferon gamma|
5826284|NCT00004401|Drug|botulism immune globulin|
5826285|NCT00004400|Drug|testosterone|
5826286|NCT00004399|Drug|magnesium sulfate|
5826287|NCT00004399|Drug|nimodipine|
5826299|NCT00004387|Procedure|fetal nigral transplantation|
5826300|NCT00004386|Genetic|recombinant adenovirus containing the ornithine transcarbamylase gene|
5826301|NCT00004382|Drug|tin mesoporphyrin|
5826302|NCT00004382|Procedure|Phototherapy|
5826303|NCT00004381|Drug|tin mesoporphyrin|
5826304|NCT00004380|Drug|relaxin|
5826305|NCT00004378|Procedure|Stem Cell Transplantation|
5826306|NCT00004376|Drug|guanfacine|
5826307|NCT00004375|Procedure|ultraviolet A-1 light treatment|
5826308|NCT00004373|Drug|alprazolam|
5826309|NCT00004368|Drug|colchicine|
5826310|NCT00004367|Procedure|Clinical vestibular tests|
5826311|NCT00004366|Procedure|Physical therapy|
5826312|NCT00004364|Drug|desmopressin|
5826313|NCT00004363|Drug|chlorpropamide|
5826314|NCT00004363|Drug|desmopressin|
5826315|NCT00004361|Drug|calcium gluconate|
5826316|NCT00004361|Drug|sodium citrate|
5826317|NCT00004360|Drug|chlorothiazide|
5826318|NCT00004359|Drug|methoxsalen|
5826319|NCT00004358|Drug|calcitonin|
5826320|NCT00004357|Drug|Methylprednisolone|IV
5826321|NCT00004357|Drug|Prednisolone|Oral
5826322|NCT00004347|Behavioral|diet|
5826323|NCT00004346|Drug|chenodeoxycholic acid|
5826324|NCT00004346|Drug|lovastatin|
5826325|NCT00004344|Drug|leuprolide|
5826326|NCT00004344|Drug|testosterone|
5826327|NCT00004340|Drug|calcitriol|
5826328|NCT00004340|Drug|growth hormone|
5826329|NCT00004339|Drug|tetrathiomolybdate|
5826330|NCT00004339|Drug|trientine|
5826331|NCT00004338|Drug|zinc acetate|
5826332|NCT00004333|Drug|NTBC|
5826333|NCT00004330|Drug|luteinizing hormone-releasing factor|
5826334|NCT00004328|Drug|enalapril|
5826335|NCT00004328|Drug|polystyrene sulfonate|
5826336|NCT00004327|Drug|octreotide|
5826337|NCT00004323|Drug|anti-thymocyte globulin|
5826338|NCT00004323|Drug|cyclophosphamide|
5826339|NCT00004323|Drug|cyclosporine|
5826340|NCT00004323|Drug|mesna|
5826341|NCT00004323|Drug|methotrexate|
5826342|NCT00004323|Drug|methylprednisolone|
5826343|NCT00004317|Drug|Leucovorin calcium|See arm descriptions
5826344|NCT00004317|Drug|Pyrimethamine|See arm descriptions
5826345|NCT00004317|Drug|Spiramycin|Spiramycin is administered before the fetal diagnosis is made.
5826346|NCT00004317|Drug|Sulfadiazine|See arm descriptions
5826347|NCT00004316|Drug|capsaicin|
5826348|NCT00004315|Drug|ursodiol|
5826349|NCT00004314|Drug|aminomidazole carboxamide riboside|
5826350|NCT00004313|Drug|dehydroepiandrosterone|
5826351|NCT00004311|Drug|leuprolide acetate|
5826352|NCT00004311|Drug|spironolactone|
5826353|NCT00004310|Drug|Clomipramine|
5826354|NCT00004307|Behavioral|Protein and calorie controlled diet|
5826355|NCT00004307|Genetic|Ornithine transcarbamylase vector|
5826356|NCT00004300|Drug|bromocriptine|
5826357|NCT00004300|Drug|sertraline hydrochloride|
5826358|NCT00004297|Drug|diazepam|
5826359|NCT00004297|Drug|lorazepam|
5826360|NCT00004294|Genetic|human glucocerebrosidase gene into autologous peripheral blood stem cells|
5826361|NCT00004293|Drug|glucocerebrosidase|
5826362|NCT00004288|Drug|olsalazine|
5826363|NCT00004287|Genetic|H5.001CBCFTR|
5826364|NCT00004286|Drug|immune globulin|
5826365|NCT00004285|Device|Standard dose, low flux hemodialysis|
5826366|NCT00004285|Device|Standard dose, high flux hemodialysis|
5826367|NCT00004285|Device|High dose, low flux hemodialysis|
5826368|NCT00004285|Device|High dose, high flux hemodialysis|
5826369|NCT00004284|Drug|potassium citrate|
5826370|NCT00004284|Drug|potassium phosphate|
5826371|NCT00004278|Drug|ganciclovir|
5826372|NCT00004276|Drug|thalidomide|
5826373|NCT00004275|Drug|growth hormone|
5826374|NCT00004275|Drug|oxandrolone|
5826375|NCT00004274|Drug|Estrogen|
5826376|NCT00004268|Drug|midodrine|
5826377|NCT00004266|Drug|Lisinopril|
5826378|NCT00004266|Drug|Nifedipine|
5826379|NCT00004266|Drug|Simvastatin|
5826380|NCT00000170|Drug|Atropine|Atropine
5826381|NCT00000170|Device|Eye Patch|Patching
5826382|NCT00000167|Procedure|Low-Intensity Laser Treatment|Initial: 60 barely visible burns, grid pattern. Re-treatment at 12 months: 30 barely visible burns, focal treatment.
5826383|NCT00000162|Procedure|Macular Argon Laser Photocoagulation|
5826384|NCT00000162|Procedure|Peripheral Scatter Argon Laser Photocoagulation|
5826385|NCT00000162|Procedure|Scatter Argon Laser Photocoagulation|
5826386|NCT00000161|Drug|Aspirin|
5826387|NCT00000161|Drug|Beta-Carotene|
5826388|NCT00000161|Drug|Vitamin C|
5826389|NCT00000161|Drug|Vitamin E|
5826390|NCT00000160|Procedure|Xenon Photocoagulation|
5826391|NCT00000160|Procedure|Argon Photocoagulation|
5826392|NCT00000160|Procedure|Photocoagulation|
5826393|NCT00000159|Drug|Sorbinil|
5826394|NCT00000158|Procedure|Argon Blue-Green Laser Photocoagulation|
5826395|NCT00000157|Drug|Aspirin|
5826396|NCT00000156|Device|Goggles|
5826397|NCT00000156|Procedure|Ambient Light Reduction|
5826398|NCT00000154|Procedure|Vitrectomy|
5826399|NCT00000153|Procedure|Blue-Green Argon Laser Treatment|
5826400|NCT00000153|Procedure|Red Krypton Laser Treatment|
5826401|NCT00000152|Drug|Aspirin|
5826402|NCT00000152|Drug|Beta-Carotene|
5826403|NCT00000151|Drug|Aspirin|
5826404|NCT00000151|Procedure|Argon Laser Photocoagulation|
5826405|NCT00000150|Procedure|Subfoveal Choroidal Neovascularization Removal|
5826406|NCT00000149|Drug|Beta Blocker|
5826407|NCT00000149|Procedure|Trabeculectomy|
5826408|NCT00000149|Procedure|Argon Laser Trabeculoplasty|
5826409|NCT00000148|Procedure|Argon Laser Trabeculoplasty|
5826410|NCT00000148|Procedure|Trabeculectomy|
5826411|NCT00000147|Drug|Methylprednisolone|
5826412|NCT00000147|Drug|Prednisone|
5826413|NCT00000146|Drug|Methylprednisolone|
5826414|NCT00000146|Drug|Prednisone|
5826415|NCT00000145|Dietary Supplement|Antioxidants|500 milligrams vitamin C; 400 IUs vitamin E; 15 milligrams beta-carotene
5826416|NCT00000145|Dietary Supplement|Zinc|80 milligrams zinc oxide; 2 milligrams of cupric oxide
5826417|NCT00000145|Dietary Supplement|Antioxidants and zinc|500 milligrams vitamin C; 400 IUs vitamin E; 15 milligrams beta-carotene; 80 milligrams zinc oxide; 2 milligrams of cupric oxide
5826418|NCT00000144|Procedure|Argon Laser Treatment|
5826419|NCT00000143|Device|Ganciclovir implant and oral ganciclovir|oral ganciclovir, 1 gm three times daily
5826420|NCT00000143|Drug|Cidofovir intravenous|intravenous, 5 mg/kg once weekly for two doses, followed by 5 mg/kg every other week
5826421|NCT00000142|Drug|Cidofovir|"Three groups:~the deferral group, treatment deferred until retinitis progressed~Low-dose cidofovir group, 5 mg/kg of body weight once weekly for two weeks, then maintenance therapy with cidofovir, 3mg/kg once every 2 weeks.~High-dose cidofovir group, 5mg/kg once weekly for 2 weeks, then maintenance therapy with cidofovir, 5mg/kg once every two weeks."
5826422|NCT00000140|Drug|Perfluoropropane|
5826423|NCT00000140|Drug|Sulfur Hexafluoride|
5826424|NCT00000140|Drug|Silicone Oil|
5826425|NCT00000139|Behavioral|Stress|
5826426|NCT00000139|Drug|Acyclovir|
5826427|NCT00000138|Drug|Prednisolone Phosphate|
5826428|NCT00000138|Drug|Acyclovir|
5826429|NCT00000137|Procedure|Histocompatibility Matching|
5826430|NCT00000136|Drug|Foscarnet|60 mg/kg every 8 hours, 90 mg/kg/day
5826431|NCT00000136|Drug|Ganciclovir|5 mg/kg every 12 hours, 5 mg/kg every 24 hours
5826432|NCT00000135|Drug|MSL-109|60 mg, IV (in vein) every two weeks, treatment continued until death or common closeout.
5826433|NCT00000135|Other|Placebo|60 mg, IV (in vein) every two weeks, treatment continued until death or common closeout.
5826434|NCT00000134|Drug|Ganciclovir|intravenous ganciclovir induction at 5 mg/kg twice daily for 2 weeks followed by maintenance at 10 mg/kg/day
5826435|NCT00000134|Drug|Foscarnet|intravenous foscarnet induction at 90 mg/kg twice daily for 2 weeks, followed by maintenance therapy at 120 mg/kg/day
5826436|NCT00000133|Procedure|Trans-scleral Cryotherapy|
5826437|NCT00000132|Drug|Betaxolol|
5826438|NCT00000132|Procedure|Argon Laser Trabeculoplasty|
5826439|NCT00000131|Procedure|Photocoagulation Therapy|
5826440|NCT00000130|Drug|Intravitreal Antibiotics|
5826441|NCT00000130|Procedure|Initial Pars Plana Vitrectomy|
5826442|NCT00000129|Procedure|Radial Keratotomy|
5826443|NCT00000128|Device|Bifocal Spectacle Lenses|
5826444|NCT00000127|Procedure|Optic Nerve Sheath Decompression Surgery|
5826445|NCT00000126|Procedure|Surgery|
5826446|NCT00000125|Drug|Topical ocular hypotensive eye drops.|Topical ocular hypotensive eye drops.
5826447|NCT00000124|Procedure|Brachytherapy|
5826448|NCT00000124|Procedure|Eye Removal|
5826449|NCT00000123|Device|Polymethyl Methacrylate-Silicone Contact Lenses|
5826450|NCT00000123|Device|Polymethyl Methacrylate Contact Lenses|
5826451|NCT00000122|Drug|5-Fluorouracil|
5826452|NCT00000121|Device|Prisms in Eyeglasses|
5826453|NCT00000120|Drug|Erythromycin Ointment|
5826454|NCT00000120|Drug|Silver Nitrate Drops|
5826455|NCT00000119|Device|Heparin Surface-Modified Intraocular Lens|
5826456|NCT00000118|Device|Sustained-Release Intraocular Drug Delivery System|
5826457|NCT00000117|Drug|Immunoglobulin|
5826458|NCT00000116|Drug|Vitamin A|
5826459|NCT00000116|Drug|Nutritional Supplement|
5826460|NCT00000115|Drug|Acetazolamide|
5826461|NCT00000114|Drug|Vitamin E|
5826462|NCT00000114|Drug|Vitamin A|
5826463|NCT00000113|Other|Progressive Addition Lenses|Varilux comfort with +2.00 addition
5826464|NCT00000113|Other|single vision lenses|
5826465|NCT00000358|Drug|Lofexidine|
5826466|NCT00000357|Drug|Buprenorphine|
5826467|NCT00000356|Drug|LAAM|
5826468|NCT00000355|Drug|Buprenorphine|
5826469|NCT00000354|Drug|Lofexidine|
5826470|NCT00000353|Drug|Buprenorphine/naloxone|
5826471|NCT00000352|Drug|Dextromethorphan|
5826472|NCT00000350|Procedure|radioactive substance|
5826473|NCT00000349|Drug|Flupenthixol|
5826474|NCT00000348|Drug|Dihydrexidine|
5826475|NCT00000347|Drug|Risperidone|
5826476|NCT00000346|Behavioral|counseling|
5826477|NCT00000345|Drug|Lofexidine|
5826478|NCT00000344|Drug|Buprenorphine/naloxone|
5826479|NCT00000343|Behavioral|counseling|
5826480|NCT00000342|Drug|Risperidone|
5826481|NCT00000341|Drug|Buprenorphine|
5826482|NCT00000340|Drug|Pemoline|
5826483|NCT00000339|Drug|Risperidone|
5826484|NCT00000338|Drug|Lisuride|
5826485|NCT00000337|Drug|Selegiline|
5826486|NCT00000336|Drug|Selegiline|
5826487|NCT00000335|Drug|Morphine|
5826488|NCT00000334|Drug|Buprenorphine|
5826489|NCT00000333|Drug|Benztropine|
5826490|NCT00000332|Drug|Nimodipine|
5826491|NCT00000331|Drug|Test Drug|
5826492|NCT00000331|Drug|Placebo Drug|
5826493|NCT00000330|Drug|Opioid-Related Disorders|
5826494|NCT00000329|Drug|Opioid-Related Disorders|
5826495|NCT00000328|Drug|Opioid-Related Disorders|
5826496|NCT00000327|Drug|Heroin Dependence|
5826497|NCT00000326|Drug|Heroin Dependence|
5826498|NCT00000325|Behavioral|Gonadorelin|
5826499|NCT00000324|Drug|Tryptophan|
5826500|NCT00000322|Behavioral|Tyrosine|
5826501|NCT00000321|Drug|Desipramine|
5826607|NCT00000252|Drug|0% N2O|
5826608|NCT00000252|Drug|10% N2O|
5826502|NCT00000320|Drug|Buprenorphine formulation: liquid vs. tablet|random assignment to liquid buprenorphine or tablet buprenorphine
5826503|NCT00000319|Drug|Buprenorphine|
5826504|NCT00000318|Drug|Buprenorphine|"Experimental Maintenance treatment with daily medication~Experimental Maintenance treatment with thrice-weekly medication"
5826505|NCT00000317|Drug|Risperidone|Risperidone (4mg/day)
5826506|NCT00000317|Drug|Placebo|Placebo
5826507|NCT00000317|Behavioral|Relapse prevention counseling|Modified manual guided relapse prevention counseling. Weekly 20 minute sessions consisting of cognitive behavioral skills. Both arms will receive this intervention.
5826508|NCT00000316|Drug|Cocaine|
5826509|NCT00000315|Drug|Cocaine|
5826510|NCT00000314|Drug|M-CPP|
5826511|NCT00000313|Drug|Fenfluramine|
5826512|NCT00000312|Drug|M-CPP|
5826513|NCT00000311|Drug|Buprenorphine|Medication and Behavioral
5826514|NCT00000311|Drug|methadone|medication and behavioral
5826515|NCT00000310|Drug|Risperidone|
5826516|NCT00000309|Drug|Risperidone|
5826517|NCT00000308|Drug|Dextroamphetamine|15 mg of d-amphetamine for first 8 weeks of study and 30 mg for the second 8 weeks
5826518|NCT00000308|Drug|D-amphetamine|15 mg of d-amphetamine for first 8 weeks of study and 30 mg for the second 8 weeks
5826519|NCT00000308|Drug|placebo|placebo
5826520|NCT00000307|Drug|Naltrexone|
5826521|NCT00000306|Drug|Dextroamphetamine|
5826522|NCT00000305|Drug|Dextroamphetamine|
5826523|NCT00000304|Drug|Dextroamphetamine|15 mg for first 8 weeks and 30 mg for 2nd 8 weeks
5826524|NCT00000304|Drug|D-Amphetamine|30 mg for the first 8 weeks and 60 for the second 8 weeks (16 weeks total)
5826525|NCT00000304|Drug|Placebo|Placebo
5826526|NCT00000303|Drug|Baclofen|
5826527|NCT00000302|Drug|Buprenorphine|
5826528|NCT00000301|Drug|Amantadine|
5826529|NCT00000300|Drug|LAAM|
5826530|NCT00000299|Drug|Buprenorphine|
5826531|NCT00000298|Drug|Buprenorphine/naloxone|
5826532|NCT00000297|Drug|Labetalol|
5826533|NCT00000296|Drug|Cotinine fumarate|
5826534|NCT00000295|Drug|Micronized Progesterone|
5826535|NCT00000294|Drug|Carvedilol|
5826536|NCT00000293|Drug|Nefazodone|
5826537|NCT00000292|Procedure|Cocaine|
5826538|NCT00000291|Drug|Labetalol|
5826539|NCT00000290|Drug|Cocaine|
5826540|NCT00000289|Drug|Ondansetron|
5826541|NCT00000288|Drug|Cotinine fumarate|
5826542|NCT00000286|Drug|Nefazodone|
5826543|NCT00000285|Drug|Phenytoin|
5826544|NCT00000284|Drug|Cotinine fumarate|
5826545|NCT00000282|Drug|Pemoline|
5826546|NCT00000281|Behavioral|Amantadine|
5826547|NCT00000280|Drug|Nimodipine|
5826548|NCT00000279|Drug|Clonidine|
5826549|NCT00000278|Drug|Disulfiram|
5826550|NCT00000277|Drug|Mazindol|
5826551|NCT00000276|Drug|Bupropion|
5826552|NCT00000275|Drug|Flupenthixol|
5826553|NCT00000274|Drug|Flupenthixol|
5826554|NCT00000273|Drug|opiates|prescription opioids
5826555|NCT00000271|Drug|Desipramine|Participants were treated with desipramine, up to 300 mg per day, or matching placebo. All participants received weekly individual manual-guided relapse prevention therapy.
5826556|NCT00000271|Drug|Placebo|Participants were treated with matching placebo. All participants received weekly individual manual-guided relapse prevention therapy.
5826557|NCT00000270|Drug|Cocaine|
5826558|NCT00000269|Drug|Pergolide|
5826559|NCT00000268|Drug|Bupropion|
5826560|NCT00000267|Drug|Risperidone|
5826561|NCT00000266|Drug|Flupenthixol|
5826562|NCT00000264|Drug|30% Nitrous oxide|
5826563|NCT00000264|Other|0.35 g/Kg ethanol|
5826564|NCT00000264|Other|0.7 g/Kg ethanol|
5826565|NCT00000264|Other|0 g/Kg ethanol|
5826566|NCT00000263|Drug|30% Nitrous oxide|
5826567|NCT00000263|Other|0.25 g/Kg ethanol|
5826568|NCT00000263|Other|0.5 g/KG ethanol|
5826569|NCT00000263|Other|0 g/Kg ethanol|
5826570|NCT00000262|Drug|30% Nitrous oxide|
5826571|NCT00000262|Drug|0.4% Sevoflurane|
5826572|NCT00000262|Drug|0.2% sevoflurane|
5826573|NCT00000262|Other|Placebo|
5826574|NCT00000261|Drug|30% Nitrous oxide|
5826575|NCT00000261|Other|Placebo|No drug (100% oxygen)
5826576|NCT00000261|Drug|0.2% sevoflurane|
5826577|NCT00000261|Drug|0.4% sevoflurane|
5826578|NCT00000261|Drug|0.6% sevoflurane|
5826579|NCT00000260|Drug|Nitrous oxide|
5826580|NCT00000259|Drug|15 % Nitrous oxide|
5826581|NCT00000259|Drug|0.3 % Sevoflurane|
5826582|NCT00000259|Drug|30% Nitrous oxide|
5826583|NCT00000259|Drug|0.6% Sevoflurane|
5826584|NCT00000259|Other|Placebo|
5826585|NCT00000258|Drug|Nitrous oxide 10% & placebo|
5826586|NCT00000258|Drug|Nitrous oxide 20% & placebo|
5826587|NCT00000258|Drug|Nitrous oxide 30% & placebo|
5826588|NCT00000258|Drug|Nitrous oxide 40% and placebo|
5826589|NCT00000257|Drug|0% N2O and 10% N2O|
5826590|NCT00000257|Drug|0% N2O and 20% N2O|
5826591|NCT00000257|Drug|0% N2O and 30% N2O|
5826592|NCT00000257|Drug|0% N2O and 40% N2O|
5826593|NCT00000256|Drug|20% N2O|
5826594|NCT00000256|Drug|40% N2O|
5826595|NCT00000256|Drug|60% N2O|
5826596|NCT00000256|Drug|80% N2O|
5826597|NCT00000255|Drug|Nitrous oxide|
5826598|NCT00000254|Drug|40% Nitrous oxide|Used as pain assay positive control
5826599|NCT00000254|Other|Sham comparator|0% isoflurane in oxygen
5826600|NCT00000254|Drug|0.2% isoflurane|
5826601|NCT00000254|Drug|0.4% isoflurane|
5826602|NCT00000254|Drug|0.6% isoflurane|
5826603|NCT00000253|Drug|10% N2O|
5826604|NCT00000253|Drug|20% N2O|
5826605|NCT00000253|Drug|30% N2O|
5826606|NCT00000253|Drug|40% N2O|
5826615|NCT00000251|Other|100% oxygen|Placebo
5826616|NCT00000250|Drug|0% N2O|Subjects will inhale 100% oxygen with no N2O for 25 min then immerse forearm in warm water and cold water
5826617|NCT00000250|Drug|40% N2O|Subjects will inhale 40% N2O then immerse forearm in warm water and cold water
5826618|NCT00000249|Drug|20% N2O|20% inhaled N2O
5826619|NCT00000249|Drug|30% N2O|30% inhaled N2O
5826620|NCT00000249|Drug|40% N2O|40% inhaled N2O
5826621|NCT00000248|Drug|Pergolide|
5826622|NCT00000246|Drug|Flumazenil|
5826623|NCT00000245|Drug|Desipramine|
5826624|NCT00000244|Drug|Dynorphin 1 - 13|
5826625|NCT00000243|Drug|Buprenorphine|
5826626|NCT00000242|Drug|Carbamazepine|
5826627|NCT00000241|Drug|Flupenthixol|
5826628|NCT00000240|Drug|Buprenorphine|
5826629|NCT00000239|Drug|Buprenorphine|
5826630|NCT00000238|Drug|Buprenorphine|
5826631|NCT00000237|Drug|Buprenorphine|
5826632|NCT00000236|Drug|Buprenorphine/naloxone|
5826633|NCT00000235|Drug|Buprenorphine|
5826634|NCT00000234|Drug|Buprenorphine|
5826635|NCT00000233|Drug|Buprenorphine|
5826636|NCT00000232|Drug|Buprenorphine|
5826637|NCT00000231|Drug|Buprenorphine|
5826638|NCT00000230|Drug|Buprenorphine|
5826639|NCT00000229|Drug|Buprenorphine|
5826640|NCT00000228|Drug|Buprenorphine|
5826641|NCT00000227|Drug|Buprenorphine|
5826642|NCT00000226|Drug|Buprenorphine|
5826643|NCT00000225|Drug|Buprenorphine|
5826644|NCT00000224|Drug|Buprenorphine|
5826645|NCT00000223|Drug|Buprenorphine|
5826646|NCT00000222|Drug|Buprenorphine|
5826647|NCT00000221|Drug|Buprenorphine|
5826648|NCT00000220|Drug|Buprenorphine|
5826649|NCT00000219|Drug|Buprenorphine|
5826650|NCT00000218|Drug|Carbamazepine|
5826651|NCT00000217|Drug|Carbamazepine|
5826652|NCT00000216|Drug|Buprenorphine|
5826653|NCT00000215|Drug|Pergolide|
5826654|NCT00000214|Drug|Buprenorphine|
5826655|NCT00000213|Drug|Fluoxetine|
5826656|NCT00000212|Drug|Desipramine|
5826657|NCT00000211|Drug|Buprenorphine|
5826658|NCT00000210|Drug|Buprenorphine|
5826659|NCT00000209|Drug|Buprenorphine|
5826660|NCT00000208|Drug|Buprenorphine|
5826661|NCT00000207|Drug|Buprenorphine|
5826662|NCT00000206|Drug|Buprenorphine|
5826663|NCT00000205|Drug|Buprenorphine|
5826664|NCT00000204|Drug|Buprenorphine|
5826665|NCT00000203|Drug|Buprenorphine|
5826666|NCT00000202|Drug|Buprenorphine|
5826667|NCT00000201|Drug|Selegiline|
5826668|NCT00000200|Drug|Methadone|normal maintenance dose
5826669|NCT00000199|Drug|Piracetam|
5826670|NCT00000198|Drug|Piracetam|
5826671|NCT00000197|Drug|Propranolol|
5826672|NCT00000196|Drug|Naltrexone|
5826673|NCT00000195|Drug|Naltrexone|
5826674|NCT00000194|Drug|Cycloserine|
5826675|NCT00000193|Drug|Gamma hydroxybutyric|
5826676|NCT00000192|Drug|Lamotrigine|
5826677|NCT00000191|Drug|Carbamazepine|
5826678|NCT00000190|Procedure|Parotid Gland|
5826679|NCT00000189|Drug|Gepirone|
5826680|NCT00000188|Drug|Selegiline|
5826681|NCT00000187|Drug|Ritanserin|
5826682|NCT00004640|Drug|Chlorhexidine rinse|chlorhexidine solution on tooth loss in low income
5826683|NCT00004639|Procedure|Furlow double z-plasty palatoplasty palate repair|
5826684|NCT00004639|Procedure|Von Langenbeck palatoplasty palate repair|
